CN112137938A - Gynostemma pentaphylla traditional Chinese medicine toothpaste - Google Patents
Gynostemma pentaphylla traditional Chinese medicine toothpaste Download PDFInfo
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- CN112137938A CN112137938A CN202011212579.XA CN202011212579A CN112137938A CN 112137938 A CN112137938 A CN 112137938A CN 202011212579 A CN202011212579 A CN 202011212579A CN 112137938 A CN112137938 A CN 112137938A
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- 235000002956 Gynostemma pentaphyllum Nutrition 0.000 title claims abstract description 125
- 239000000606 toothpaste Substances 0.000 title claims abstract description 84
- 229940034610 toothpaste Drugs 0.000 title claims abstract description 83
- 239000003814 drug Substances 0.000 title claims abstract description 73
- 241001065361 Gynostemma Species 0.000 title claims abstract description 42
- 239000000843 powder Substances 0.000 claims abstract description 53
- 238000000227 grinding Methods 0.000 claims abstract description 41
- 239000000419 plant extract Substances 0.000 claims abstract description 28
- 239000003153 chemical reaction reagent Substances 0.000 claims abstract description 23
- 238000012216 screening Methods 0.000 claims abstract description 23
- 239000002994 raw material Substances 0.000 claims abstract description 22
- LRCFXGAMWKDGLA-UHFFFAOYSA-N dioxosilane;hydrate Chemical compound O.O=[Si]=O LRCFXGAMWKDGLA-UHFFFAOYSA-N 0.000 claims abstract description 18
- 229960004029 silicic acid Drugs 0.000 claims abstract description 18
- 238000004140 cleaning Methods 0.000 claims abstract description 15
- FUFJGUQYACFECW-UHFFFAOYSA-L calcium hydrogenphosphate Chemical compound [Ca+2].OP([O-])([O-])=O FUFJGUQYACFECW-UHFFFAOYSA-L 0.000 claims abstract description 13
- 235000019700 dicalcium phosphate Nutrition 0.000 claims abstract description 13
- 238000000034 method Methods 0.000 claims abstract description 6
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims abstract description 5
- 229910052791 calcium Inorganic materials 0.000 claims abstract description 5
- 239000011575 calcium Substances 0.000 claims abstract description 5
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 55
- 239000000284 extract Substances 0.000 claims description 35
- 238000000605 extraction Methods 0.000 claims description 30
- 229930187479 gypenoside Natural products 0.000 claims description 23
- FBFMBWCLBGQEBU-RXMALORBSA-N (2s,3r,4s,5s,6r)-2-[(2r,3r,4s,5s,6r)-2-[[(3s,5r,6s,8r,9r,10r,12r,13r,14r,17s)-3,12-dihydroxy-4,4,8,10,14-pentamethyl-17-[(2s)-6-methyl-2-[(2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyhept-5-en-2-yl]-2,3,5,6,7,9,11,12,13,15,16,17-dodecah Chemical class O([C@@](C)(CCC=C(C)C)[C@@H]1[C@@H]2[C@@]([C@@]3(C[C@@H]([C@H]4C(C)(C)[C@@H](O)CC[C@]4(C)[C@H]3C[C@H]2O)O[C@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)O[C@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)O)C)(C)CC1)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O FBFMBWCLBGQEBU-RXMALORBSA-N 0.000 claims description 16
- 238000001816 cooling Methods 0.000 claims description 16
- 239000007788 liquid Substances 0.000 claims description 16
- 238000003756 stirring Methods 0.000 claims description 16
- 229940079593 drug Drugs 0.000 claims description 10
- 238000010438 heat treatment Methods 0.000 claims description 10
- 239000011347 resin Substances 0.000 claims description 10
- 229920005989 resin Polymers 0.000 claims description 10
- 238000005406 washing Methods 0.000 claims description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 10
- 229930182490 saponin Natural products 0.000 claims description 8
- 150000007949 saponins Chemical class 0.000 claims description 8
- 238000001914 filtration Methods 0.000 claims description 7
- ZRBFCAALKKNCJG-UHFFFAOYSA-N gypenoside-XVII Natural products C1CC(C2(CCC3C(C)(C)C(OC4C(C(O)C(O)C(CO)O4)O)CCC3(C)C2CC2O)C)(C)C2C1C(C)(CCC=C(C)C)OC(C(C(O)C1O)O)OC1COC1OC(CO)C(O)C(O)C1O ZRBFCAALKKNCJG-UHFFFAOYSA-N 0.000 claims description 7
- 239000001397 quillaja saponaria molina bark Substances 0.000 claims description 7
- 238000010992 reflux Methods 0.000 claims description 7
- 239000003242 anti bacterial agent Substances 0.000 claims description 6
- 238000004806 packaging method and process Methods 0.000 claims description 6
- 239000000706 filtrate Substances 0.000 claims description 5
- 239000000796 flavoring agent Substances 0.000 claims description 5
- 235000013355 food flavoring agent Nutrition 0.000 claims description 5
- 239000003906 humectant Substances 0.000 claims description 5
- 239000003755 preservative agent Substances 0.000 claims description 5
- 238000010298 pulverizing process Methods 0.000 claims description 5
- 239000004094 surface-active agent Substances 0.000 claims description 5
- 239000002562 thickening agent Substances 0.000 claims description 5
- 238000001291 vacuum drying Methods 0.000 claims description 5
- 241000628997 Flos Species 0.000 claims 2
- 230000002335 preservative effect Effects 0.000 claims 1
- 210000000214 mouth Anatomy 0.000 abstract description 9
- 206010018291 Gingival swelling Diseases 0.000 abstract description 5
- 208000025865 Ulcer Diseases 0.000 abstract description 5
- 231100000397 ulcer Toxicity 0.000 abstract description 5
- 208000002193 Pain Diseases 0.000 abstract description 4
- 230000007797 corrosion Effects 0.000 abstract description 3
- 238000005260 corrosion Methods 0.000 abstract description 3
- 239000000126 substance Substances 0.000 abstract description 3
- 240000006509 Gynostemma pentaphyllum Species 0.000 description 83
- 241000205585 Aquilegia canadensis Species 0.000 description 8
- 241000180649 Panax notoginseng Species 0.000 description 5
- 235000003143 Panax notoginseng Nutrition 0.000 description 5
- 238000005516 engineering process Methods 0.000 description 5
- 235000017709 saponins Nutrition 0.000 description 5
- 235000009328 Amaranthus caudatus Nutrition 0.000 description 4
- 235000000604 Chrysanthemum parthenium Nutrition 0.000 description 4
- 241001146155 Emilia Species 0.000 description 4
- 235000019049 Emilia coccinea Nutrition 0.000 description 4
- 241000207925 Leonurus Species 0.000 description 4
- 235000000802 Leonurus cardiaca ssp. villosus Nutrition 0.000 description 4
- 244000111146 Sonchus arvensis Species 0.000 description 4
- 235000008132 Sonchus arvensis ssp. uliginosus Nutrition 0.000 description 4
- 239000003795 chemical substances by application Substances 0.000 description 4
- 239000006072 paste Substances 0.000 description 4
- 244000131316 Panax pseudoginseng Species 0.000 description 3
- 150000001875 compounds Chemical class 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 239000003480 eluent Substances 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- 206010006326 Breath odour Diseases 0.000 description 2
- 208000025157 Oral disease Diseases 0.000 description 2
- 235000003181 Panax pseudoginseng Nutrition 0.000 description 2
- 241000219784 Sophora Species 0.000 description 2
- 239000004480 active ingredient Substances 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 230000018109 developmental process Effects 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- 230000006872 improvement Effects 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 208000030194 mouth disease Diseases 0.000 description 2
- 230000001954 sterilising effect Effects 0.000 description 2
- 208000018380 Chemical injury Diseases 0.000 description 1
- 206010018286 Gingival pain Diseases 0.000 description 1
- 206010062717 Increased upper airway secretion Diseases 0.000 description 1
- 208000007117 Oral Ulcer Diseases 0.000 description 1
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 description 1
- 235000003140 Panax quinquefolius Nutrition 0.000 description 1
- 206010044038 Tooth erosion Diseases 0.000 description 1
- 239000003082 abrasive agent Substances 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 229930013930 alkaloid Natural products 0.000 description 1
- 150000003797 alkaloid derivatives Chemical class 0.000 description 1
- 208000002399 aphthous stomatitis Diseases 0.000 description 1
- 230000003796 beauty Effects 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 210000000170 cell membrane Anatomy 0.000 description 1
- 210000002421 cell wall Anatomy 0.000 description 1
- 239000000551 dentifrice Substances 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 229940077441 fluorapatite Drugs 0.000 description 1
- 229910052587 fluorapatite Inorganic materials 0.000 description 1
- 235000008434 ginseng Nutrition 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 239000005445 natural material Substances 0.000 description 1
- VSIIXMUUUJUKCM-UHFFFAOYSA-D pentacalcium;fluoride;triphosphate Chemical compound [F-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O VSIIXMUUUJUKCM-UHFFFAOYSA-D 0.000 description 1
- 201000001245 periodontitis Diseases 0.000 description 1
- 208000026435 phlegm Diseases 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/24—Phosphorous; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/25—Silicon; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/805—Corresponding aspects not provided for by any of codes A61K2800/81 - A61K2800/95
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Inorganic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Cosmetics (AREA)
Abstract
The invention relates to the field of daily chemical industry, in particular to gynostemma pentaphylla traditional Chinese medicine toothpaste, which comprises high-grade toothpaste raw materials, gynostemma pentaphylla, hydrated silica, calcium hydrophosphate, other reagents and plant extracts, wherein the plant extracts comprise the following components in parts by weight: high-grade toothpaste raw materials: 92 percent; gynostemma pentaphylla: 4 percent; hydrated silica: 0.5 percent; calcium hydrogen phosphate: 0.5 percent; and (3) the rest reagents: 1 percent; plant extracts: 2 percent. The method comprises the following steps: s1, screening and cleaning: firstly, screening high-quality gynostemma pentaphylla, and then cleaning the gynostemma pentaphylla; s2, grinding: dividing the gynostemma pentaphylla into multiple parts, then placing the gynostemma pentaphylla into a grinding machine for grinding, gradually grinding the gynostemma pentaphylla divided into multiple parts into the grinding machine to obtain gynostemma pentaphylla powder, and repeatedly grinding the ground gynostemma pentaphylla by the grinding machine for 6-8 times. The invention has the advantages of solving the problems of dental ulcer, gum swelling and pain, refreshing the oral cavity, solving the phenomenon of peculiar smell in the oral cavity, improving the corrosion resistance of teeth and prolonging the service life of the teeth.
Description
Technical Field
The invention relates to the field of daily chemical industry, in particular to gynostemma pentaphylla traditional Chinese medicine toothpaste.
Background
The toothpaste is a cleaning article commonly used in daily life, is a dentifrice, is generally in a gel shape, can be usually smeared on a toothbrush for cleaning teeth, keeps the beauty and brightness of the teeth, has a long history, and with the continuous development of scientific technology, the continuous improvement and perfection of manufacturing technology and equipment, various types of toothpaste are appeared one after another, the quality and the grade of products are continuously improved, and as far as 2019, the variety of the toothpaste is changed from single cleaning type toothpaste, the toothpaste is developed into hundreds of multifunctional toothpastes with complete varieties and various functions, thereby meeting the requirements of different consumption levels.
Gynostemma herb enjoys 'long life herb' and 'southern ginseng'. It has effects in removing toxic materials, eliminating phlegm, relieving bite, and resisting ulcer. The oral care product is developed by taking the gypenosides as a main body, toothpaste as a carrier and combining the advanced extract technology, and adopts high-grade toothpaste raw materials to keep the oral cavity fresh, remove oral diseases and protect the oral health while keeping the active ingredients of the gypenoside.
Chinese patent No. CN109745263A provides a compound traditional Chinese medicine toothpaste containing radix sophorae subprostratae and radix notoginseng, which comprises 0.05-2% of the composition of the radix sophorae subprostratae and the radix notoginseng, wherein the composition of the radix sophorae subprostratae and the radix notoginseng is total saponins of radix notoginseng and alkaloid extract of radix sophorae subprostratae; and the preparation method of the compound traditional Chinese medicine toothpaste containing the subprostrate sophora and the pseudo-ginseng comprises the following steps: adding the radix Sophorae Tonkinensis and Notoginseng radix composition into toothpaste matrix, stirring and grinding for 30-60min, aging for 60-180min, naturally cooling to room temperature, and packaging. The subprostrate sophora and pseudo-ginseng compound traditional Chinese medicine toothpaste prepared by the invention has the advantages of high safety, good effects of sterilizing and treating periodontitis and the like.
The existing traditional Chinese medicine toothpaste can not better solve the problems of dental ulcer, gum swelling and pain, mouth freshening and oral odor, has relatively poor tooth corrosion resistance and reduces the service life of teeth, so that the development of gynostemma pentaphylla traditional Chinese medicine toothpaste is urgently needed.
Disclosure of Invention
The invention aims to provide gynostemma pentaphylla traditional Chinese medicine toothpaste to solve the problems that dental ulcer, gum swelling and pain, mouth freshening and bad breath odor phenomena cannot be solved relatively well, the corrosion resistance of teeth is relatively poor and the service life of teeth is reduced in the background technology.
The technical scheme of the invention is as follows: the gynostemma pentaphylla traditional Chinese medicine toothpaste comprises high-grade toothpaste raw materials, gynostemma pentaphylla, hydrated silica, calcium hydrogen phosphate, other reagents and plant extracts, wherein the plant extracts comprise the following components in parts by weight:
high-grade toothpaste raw materials: 92% -95%;
gynostemma pentaphylla: 3% -4%;
hydrated silica: 0.2% -0.5%;
calcium hydrogen phosphate: 0.3% -0.5%;
and (3) the rest reagents: 0.5% -1%;
plant extracts: 1 to 2 percent.
Further, the method comprises the following steps:
s1, screening and cleaning: firstly, screening high-quality gynostemma pentaphylla, and then cleaning the gynostemma pentaphylla;
s2, grinding: dividing the gynostemma pentaphylla into multiple parts, then placing the gynostemma pentaphylla into a grinding machine for grinding, and gradually grinding the gynostemma pentaphylla divided into multiple parts into the grinding machine to obtain gynostemma pentaphylla powder;
s3, screening: dividing the gynostemma pentaphylla powder into a plurality of parts, gradually pouring each part of gynostemma pentaphylla powder onto a multilayer filter screen, and screening the gynostemma pentaphylla powder on the bottommost filter screen layer to obtain the gynostemma pentaphylla powder;
s4, extraction: putting the gynostemma pentaphylla powder in the S3 into an extraction device, performing ethanol reflux extraction on the gynostemma pentaphylla powder, combining extracting solutions, recovering ethanol until no ethanol smell exists, adding water to dilute into a solution, wherein the concentration of the solution is 0.1g crude drug per 1ml, and filtering to obtain a filtrate which is defined as a liquid medicine;
s5, eluting by a washing machine: adding the liquid medicine in the S4 to a pretreated macroporous resin column, washing with water until the effluent is colorless, eluting with 60-90% ethanol, collecting the eluate, recovering ethanol, concentrating, vacuum drying, and pulverizing into fine powder to obtain herba Gynostemmatis total saponin;
s6, stirring: pouring high-grade toothpaste raw materials into a stirrer with a heating function, dividing the gypenosides into a plurality of parts, gradually adding different plant extracts, adding other reagents, hydrated silica and calcium hydrogen phosphate, fully stirring the toothpaste to obtain traditional Chinese medicine toothpaste containing the gypenoside, and cooling after stirring by the stirrer to obtain the traditional Chinese medicine toothpaste;
s7, cooling and subpackaging: naturally cooling the traditional Chinese medicine toothpaste containing gynostemma pentaphylla obtained in the step S6, and then subpackaging and packaging the traditional Chinese medicine toothpaste containing gynostemma pentaphylla.
Further, in S2, the grinding machine repeatedly grinds the ground gynostemma pentaphyllum for 6-8 times.
Further, the plant extract comprises one or more of honeysuckle extract, sowthistle tasselflower herb extract, folium artemisiae argyi extract, honeysuckle extract and motherwort extract.
Further, in the step S4, the temperature in the extraction device is set to be 55-65 ℃, and simultaneously, a vacuum pump is adopted to reduce the pressure in the extraction device, wherein the extraction pressure is 600-.
Further, in the step S6, the heating temperature in the stirrer is set at 65-70 ℃, the gypenosides are divided into 6-8 parts, and the interval between the addition of the gypenosides is 3-5 min.
Furthermore, in the S4, each gram of the medicinal powder is extracted by 6-10 ml of 30-70% ethanol under reflux for 1-4 times, and each time lasts for 1-2 hours.
Further, in the S5, the weight ratio of crude drug to dry resin in the liquid medicine is 1: 1-1: 2, and the liquid medicine is concentrated to thick paste with the relative density of 1.5-2 at 60 ℃ after ethanol is recovered.
Further, in the step S3, the gynostemma pentaphyllum powder is divided into 3 to 5 parts, and then the gynostemma pentaphyllum powder is gradually filtered, and the multiple layers of filter screens are distributed at equal intervals from top to bottom, wherein the mesh sizes of the multiple layers of filter screens are respectively 200 to 100 meshes.
Further, surfactants, preservatives, flavoring agents, humectants, thickeners, natural antibacterial agents, and abrasives are employed in the remaining agents.
Compared with the prior art, the gynostemma pentaphylla traditional Chinese medicine toothpaste provided by the invention has the following improvements and advantages:
(1) the oral care product is developed by taking the gypenosides as a main body, taking toothpaste as a carrier and combining the advanced extract technology, keeps the active ingredients of the gypenoside, adopts high-grade toothpaste raw materials, keeps the oral cavity fresh, removes oral diseases, protects the oral health, and can solve the phenomena of oral ulcer, gum swelling and pain, fresh oral cavity and bad breath by utilizing the characteristics of the gypenoside.
(2) The hydrated silica and the calcium hydrogen phosphate which are easily dissolved by acid in tooth tissues form the insoluble fluorapatite, so that the corrosion resistance of the teeth is improved, and the service life of the teeth is prolonged.
(3) The multilayer filter screen that adopts multilayer filter screen can once only to strand blue extract raw materials powder multilayer filtration, improves the efficiency of filtering the screening to strand blue extract raw materials powder, improves the quality of strand blue extract raw materials powder simultaneously.
(4) All the other reagents of adoption, all the other reagents are natural substance, do not have the chemical synthesis material, avoid chemical injury user's oral cavity and tooth for environmental protection and safety more when traditional chinese medicine toothpaste uses, wherein natural antibacterial agent: the acidic and alkaline substances destroy the cell wall and cell membrane of the microorganism, and further solidify cell protein to realize sterilization.
Detailed Description
The technical solutions in the embodiments of the present invention are clearly and completely described, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Example one
The gynostemma pentaphylla traditional Chinese medicine toothpaste comprises high-grade toothpaste raw materials, gynostemma pentaphylla, hydrated silica, calcium hydrogen phosphate, other reagents and plant extracts, wherein the plant extracts comprise the following components in parts by weight:
high-grade toothpaste raw materials: 96 percent;
hydrated silica: 0.5 percent;
calcium hydrogen phosphate: 0.5 percent;
and (3) the rest reagents: 1 percent;
plant extracts: 2 percent.
Further, the method comprises the following steps:
s1, screening and cleaning: firstly, screening high-quality gynostemma pentaphylla, and then cleaning the gynostemma pentaphylla;
s2, grinding: dividing the gynostemma pentaphylla into multiple parts, then placing the gynostemma pentaphylla into a grinding machine for grinding, gradually grinding the gynostemma pentaphylla divided into multiple parts into the grinding machine to obtain gynostemma pentaphylla powder, and repeatedly grinding the ground gynostemma pentaphylla by the grinding machine for 8 times;
s3, screening: dividing the gynostemma pentaphylla powder into a plurality of parts, gradually pouring each part of gynostemma pentaphylla powder onto a multilayer filter screen, and screening the gynostemma pentaphylla powder on the bottommost filter screen layer to obtain the gynostemma pentaphylla powder;
s4, extraction: putting the gynostemma pentaphylla powder in the S3 into an extraction device, setting the temperature in the extraction device at 65 ℃, simultaneously reducing the pressure in the extraction device by using a vacuum pump, wherein the extraction pressure is 700BAR, carrying out reflux extraction on the gynostemma pentaphylla powder for 3 times by using 10 milliliters of 60 percent ethanol for every gram of medicinal powder, 2 hours for each time, combining extracting solutions, recovering the ethanol until no alcohol smell exists, adding water to dilute the solution into the solution, wherein the concentration of the solution is that each 1ml contains 0.1g of crude drug, and filtering the solution to obtain filtrate which is defined as medicinal liquid;
s5, eluting by a washing machine: adding the liquid medicine in the S4 to a pretreated macroporous resin column, wherein the weight ratio of crude drugs to dry resin in the liquid medicine is 1: 2, firstly washing with water until effluent is colorless, then eluting with 90% ethanol, collecting eluent, recovering ethanol, concentrating to obtain thick paste with the relative density of 1.8 at 60 ℃, vacuum drying, and pulverizing into fine powder to obtain the gynostemma total saponin;
s6, stirring: pouring high-grade toothpaste raw materials into a stirrer with a heating function, setting the heating temperature in the stirrer at 70 ℃, dividing the gypenosides into 8 parts, adding the gypenosides every 5min, dividing the gypenosides into a plurality of parts, gradually adding different plant extracts, wherein the plant extracts comprise one or more mixed extracts of honeysuckle extract, sowthistle tasselflower herb extract, folium artemisiae argyi extract, honeysuckle extract and motherwort herb extract, then adding the rest reagents, hydrated silica and calcium hydrophosphate, and surface active agents, preservatives, flavoring agents, humectants, thickening agents, natural antibacterial agents and friction agents adopted in the rest reagents, fully stirring the toothpaste to obtain traditional Chinese medicine toothpaste containing gynostemma pentaphylla, and cooling the traditional Chinese medicine toothpaste after stirring by the stirrer to obtain the traditional Chinese medicine toothpaste;
s7, cooling and subpackaging: naturally cooling the traditional Chinese medicine toothpaste containing gynostemma pentaphylla obtained in the step S6, and then subpackaging and packaging the traditional Chinese medicine toothpaste containing gynostemma pentaphylla.
Example two
The gynostemma pentaphylla traditional Chinese medicine toothpaste comprises high-grade toothpaste raw materials, gynostemma pentaphylla, hydrated silica, calcium hydrogen phosphate, other reagents and plant extracts, wherein the plant extracts comprise the following components in parts by weight:
high-grade toothpaste raw materials: 92 percent;
gynostemma pentaphylla: 2 percent;
hydrated silica: 0.5 percent;
calcium hydrogen phosphate: 0.5 percent;
and (3) the rest reagents: 1 percent;
plant extracts: 2 percent.
Further, the method comprises the following steps:
s1, screening and cleaning: firstly, screening high-quality gynostemma pentaphylla, and then cleaning the gynostemma pentaphylla;
s2, grinding: dividing the gynostemma pentaphylla into multiple parts, then placing the gynostemma pentaphylla into a grinding machine for grinding, gradually grinding the gynostemma pentaphylla divided into multiple parts into the grinding machine to obtain gynostemma pentaphylla powder, and repeatedly grinding the ground gynostemma pentaphylla by the grinding machine for 8 times;
s3, screening: dividing the gynostemma pentaphylla powder into a plurality of parts, gradually pouring each part of gynostemma pentaphylla powder onto a multilayer filter screen, and screening the gynostemma pentaphylla powder on the bottommost filter screen layer to obtain the gynostemma pentaphylla powder;
s4, extraction: putting the gynostemma pentaphylla powder in the S3 into an extraction device, setting the temperature in the extraction device at 65 ℃, simultaneously reducing the pressure in the extraction device by using a vacuum pump, wherein the extraction pressure is 700BAR, carrying out reflux extraction on the gynostemma pentaphylla powder for 3 times by using 10 milliliters of 60 percent ethanol for every gram of medicinal powder, 2 hours for each time, combining extracting solutions, recovering the ethanol until no alcohol smell exists, adding water to dilute the solution into the solution, wherein the concentration of the solution is that each 1ml contains 0.1g of crude drug, and filtering the solution to obtain filtrate which is defined as medicinal liquid;
s5, eluting by a washing machine: adding the liquid medicine in the S4 to a pretreated macroporous resin column, wherein the weight ratio of crude drugs to dry resin in the liquid medicine is 1: 2, firstly washing with water until effluent is colorless, then eluting with 90% ethanol, collecting eluent, recovering ethanol, concentrating to obtain thick paste with the relative density of 1.8 at 60 ℃, vacuum drying, and pulverizing into fine powder to obtain the gynostemma total saponin;
s6, stirring: pouring high-grade toothpaste raw materials into a stirrer with a heating function, setting the heating temperature in the stirrer at 70 ℃, dividing the gypenosides into 8 parts, adding the gypenosides every 5min, dividing the gypenosides into a plurality of parts, gradually adding different plant extracts, wherein the plant extracts comprise one or more mixed extracts of honeysuckle extract, sowthistle tasselflower herb extract, folium artemisiae argyi extract, honeysuckle extract and motherwort herb extract, then adding the rest reagents, hydrated silica and calcium hydrophosphate, and surface active agents, preservatives, flavoring agents, humectants, thickening agents, natural antibacterial agents and friction agents adopted in the rest reagents, fully stirring the toothpaste to obtain traditional Chinese medicine toothpaste containing gynostemma pentaphylla, and cooling the traditional Chinese medicine toothpaste after stirring by the stirrer to obtain the traditional Chinese medicine toothpaste;
s7, cooling and subpackaging: naturally cooling the traditional Chinese medicine toothpaste containing gynostemma pentaphylla obtained in the step S6, and then subpackaging and packaging the traditional Chinese medicine toothpaste containing gynostemma pentaphylla.
EXAMPLE III
The gynostemma pentaphylla traditional Chinese medicine toothpaste comprises high-grade toothpaste raw materials, gynostemma pentaphylla, hydrated silica, calcium hydrogen phosphate, other reagents and plant extracts, wherein the plant extracts comprise the following components in parts by weight:
high-grade toothpaste raw materials: 92 percent;
gynostemma pentaphylla: 4 percent;
hydrated silica: 0.5 percent;
calcium hydrogen phosphate: 0.5 percent;
and (3) the rest reagents: 1 percent;
plant extracts: 2 percent.
Further, the method comprises the following steps:
s1, screening and cleaning: firstly, screening high-quality gynostemma pentaphylla, and then cleaning the gynostemma pentaphylla;
s2, grinding: dividing the gynostemma pentaphylla into multiple parts, then placing the gynostemma pentaphylla into a grinding machine for grinding, gradually grinding the gynostemma pentaphylla divided into multiple parts into the grinding machine to obtain gynostemma pentaphylla powder, and repeatedly grinding the ground gynostemma pentaphylla by the grinding machine for 8 times;
s3, screening: dividing the gynostemma pentaphylla powder into a plurality of parts, gradually pouring each part of gynostemma pentaphylla powder onto a multilayer filter screen, and screening the gynostemma pentaphylla powder on the bottommost filter screen layer to obtain the gynostemma pentaphylla powder;
s4, extraction: putting the gynostemma pentaphylla powder in the S3 into an extraction device, setting the temperature in the extraction device at 65 ℃, simultaneously reducing the pressure in the extraction device by using a vacuum pump, wherein the extraction pressure is 700BAR, carrying out reflux extraction on the gynostemma pentaphylla powder for 3 times by using 10 milliliters of 60 percent ethanol for every gram of medicinal powder, 2 hours for each time, combining extracting solutions, recovering the ethanol until no alcohol smell exists, adding water to dilute the solution into the solution, wherein the concentration of the solution is that each 1ml contains 0.1g of crude drug, and filtering the solution to obtain filtrate which is defined as medicinal liquid;
s5, eluting by a washing machine: adding the liquid medicine in the S4 to a pretreated macroporous resin column, wherein the weight ratio of crude drugs to dry resin in the liquid medicine is 1: 2, firstly washing with water until effluent is colorless, then eluting with 90% ethanol, collecting eluent, recovering ethanol, concentrating to obtain thick paste with the relative density of 1.8 at 60 ℃, vacuum drying, and pulverizing into fine powder to obtain the gynostemma total saponin;
s6, stirring: pouring high-grade toothpaste raw materials into a stirrer with a heating function, setting the heating temperature in the stirrer at 70 ℃, dividing the gypenosides into 8 parts, adding the gypenosides every 5min, dividing the gypenosides into a plurality of parts, gradually adding different plant extracts, wherein the plant extracts comprise one or more mixed extracts of honeysuckle extract, sowthistle tasselflower herb extract, folium artemisiae argyi extract, honeysuckle extract and motherwort herb extract, then adding the rest reagents, hydrated silica and calcium hydrophosphate, and surface active agents, preservatives, flavoring agents, humectants, thickening agents, natural antibacterial agents and friction agents adopted in the rest reagents, fully stirring the toothpaste to obtain traditional Chinese medicine toothpaste containing gynostemma pentaphylla, and cooling the traditional Chinese medicine toothpaste after stirring by the stirrer to obtain the traditional Chinese medicine toothpaste;
s7, cooling and subpackaging: naturally cooling the traditional Chinese medicine toothpaste containing gynostemma pentaphylla obtained in the step S6, and then subpackaging and packaging the traditional Chinese medicine toothpaste containing gynostemma pentaphylla.
The traditional Chinese medicine toothpaste obtained in the first embodiment, the second embodiment and the third embodiment is not added with the gypenosides respectively, and the added gypenoside is different in amount, so that the obtained toothpaste is provided for each group of 100 experimenters respectively, and the experiment shows that the gypenoside obtained in the third embodiment has the best effect, can solve the phenomena of dental ulcer, gingival swelling and pain, mouth freshening and oral odor.
The previous description of the disclosed embodiments is provided to enable any person skilled in the art to make or use the present invention. Various modifications to these embodiments will be readily apparent to those skilled in the art, and the generic principles defined herein may be applied to other embodiments without departing from the spirit or scope of the invention. Thus, the present invention is not intended to be limited to the embodiments shown herein but is to be accorded the widest scope consistent with the principles and novel features disclosed herein.
Claims (10)
1. The gynostemma pentaphylla traditional Chinese medicine toothpaste is characterized in that: comprises high-grade toothpaste raw materials, gynostemma pentaphylla, hydrated silica, calcium hydrophosphate, other reagents and plant extracts, wherein the plant extracts comprise the following components in parts by weight:
high-grade toothpaste raw materials: 92% -95%;
gynostemma pentaphylla: 3% -4%;
hydrated silica: 0.2% -0.5%;
calcium hydrogen phosphate: 0.3% -0.5%;
and (3) the rest reagents: 0.5% -1%;
plant extracts: 1 to 2 percent.
2. The gynostemma pentaphylla traditional Chinese medicine toothpaste according to claim 1, wherein: the method comprises the following steps:
s1, screening and cleaning: firstly, screening high-quality gynostemma pentaphylla, and then cleaning the gynostemma pentaphylla;
s2, grinding: dividing the gynostemma pentaphylla into multiple parts, then placing the gynostemma pentaphylla into a grinding machine for grinding, and gradually grinding the gynostemma pentaphylla divided into multiple parts into the grinding machine to obtain gynostemma pentaphylla powder;
s3, screening: dividing the gynostemma pentaphylla powder into a plurality of parts, gradually pouring each part of gynostemma pentaphylla powder onto a multilayer filter screen, and screening the gynostemma pentaphylla powder on the bottommost filter screen layer to obtain the gynostemma pentaphylla powder;
s4, extraction: putting the gynostemma pentaphylla powder in the S3 into an extraction device, performing ethanol reflux extraction on the gynostemma pentaphylla powder, combining extracting solutions, recovering ethanol until no ethanol smell exists, adding water to dilute into a solution, wherein the concentration of the solution is 0.1g crude drug per 1ml, and filtering to obtain a filtrate which is defined as a liquid medicine;
s5, eluting by a washing machine: adding the liquid medicine in the S4 to a pretreated macroporous resin column, washing with water until the effluent is colorless, eluting with 60-90% ethanol, collecting the eluate, recovering ethanol, concentrating, vacuum drying, and pulverizing into fine powder to obtain herba Gynostemmatis total saponin;
s6, stirring: pouring high-grade toothpaste raw materials into a stirrer with a heating function, dividing the gypenosides into a plurality of parts, gradually adding different plant extracts, adding other reagents, hydrated silica and calcium hydrogen phosphate, fully stirring the toothpaste to obtain traditional Chinese medicine toothpaste containing the gypenoside, and cooling after stirring by the stirrer to obtain the traditional Chinese medicine toothpaste;
s7, cooling and subpackaging: naturally cooling the traditional Chinese medicine toothpaste containing gynostemma pentaphylla obtained in the step S6, and then subpackaging and packaging the traditional Chinese medicine toothpaste containing gynostemma pentaphylla.
3. The gynostemma pentaphylla traditional Chinese medicine toothpaste according to claim 2, wherein: and in the S2, the grinding machine repeatedly grinds the ground gynostemma pentaphylla for 6-8 times.
4. The gynostemma pentaphylla traditional Chinese medicine toothpaste according to claim 2, wherein: the plant extract comprises one or more of flos Lonicerae extract, herba Rumicis Japonici extract, folium Artemisiae Argyi extract, flos Lonicerae extract, and herba Leonuri extract.
5. The gynostemma pentaphylla traditional Chinese medicine toothpaste according to claim 2, wherein: in the S4, the temperature in the extraction device is set to be 55-65 ℃, and simultaneously, a vacuum pump is adopted to reduce the pressure in the extraction device, and the extraction pressure is 600-850 BAR.
6. The gynostemma pentaphylla traditional Chinese medicine toothpaste according to claim 2, wherein: in S6, the heating temperature in the stirrer is set at 65-70 deg.C, the total saponin of herba Gynostemmatis is divided into 6-8 parts, and the interval between adding total saponin of herba Gynostemmatis is 3-5 min.
7. The gynostemma pentaphylla traditional Chinese medicine toothpaste according to claim 2, wherein: in the S4, each gram of the medicinal powder is extracted by 6-10 ml of 30-70% ethanol under reflux for 1-4 times, and each time lasts for 1-2 hours.
8. The gynostemma pentaphylla traditional Chinese medicine toothpaste according to claim 2, wherein: in the S5, the weight ratio of crude drug to dry resin in the liquid medicine is 1: 1-1: 2, recovering ethanol, and concentrating to obtain soft extract with relative density of 1.5-2 at 60 deg.C.
9. The gynostemma pentaphylla traditional Chinese medicine toothpaste according to claim 2, wherein: in the step S3, the gynostemma pentaphylla powder is divided into 3-5 parts, then the gynostemma pentaphylla powder is gradually filtered, and the adopted multilayer filter screens are distributed at equal intervals from top to bottom, wherein the mesh sizes of the multilayer filter screens are respectively 200-100 meshes.
10. The gynostemma pentaphylla traditional Chinese medicine toothpaste according to claim 2, wherein: and the other reagents comprise a surfactant, a preservative, a flavoring agent, a humectant, a thickening agent, a natural antibacterial agent and an abrasive.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN113171320A (en) * | 2021-05-08 | 2021-07-27 | 广州市盛龙口腔清洁用品有限公司 | Plant-flavor toothpaste and preparation method thereof |
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| CN101037453A (en) * | 2006-03-16 | 2007-09-19 | 杜洋 | Preparation method of gypenoside |
| CN105832594A (en) * | 2016-04-07 | 2016-08-10 | 张国英 | Traditional Chinese medicinal lipid reducing toothpaste and preparation method thereof |
| CN110917059A (en) * | 2020-01-02 | 2020-03-27 | 浙江寿仙谷健康科技有限公司 | Efficacy agent of toothpaste with anti-inflammation and hemostasis effects, toothpaste containing efficacy agent and preparation method of toothpaste |
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- 2020-11-03 CN CN202011212579.XA patent/CN112137938A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101037453A (en) * | 2006-03-16 | 2007-09-19 | 杜洋 | Preparation method of gypenoside |
| CN105832594A (en) * | 2016-04-07 | 2016-08-10 | 张国英 | Traditional Chinese medicinal lipid reducing toothpaste and preparation method thereof |
| CN110917059A (en) * | 2020-01-02 | 2020-03-27 | 浙江寿仙谷健康科技有限公司 | Efficacy agent of toothpaste with anti-inflammation and hemostasis effects, toothpaste containing efficacy agent and preparation method of toothpaste |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN113171320A (en) * | 2021-05-08 | 2021-07-27 | 广州市盛龙口腔清洁用品有限公司 | Plant-flavor toothpaste and preparation method thereof |
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