CN108721180A - A kind of antibacterial oral cavity composition containing honeysuckle, product and preparation method thereof - Google Patents
A kind of antibacterial oral cavity composition containing honeysuckle, product and preparation method thereof Download PDFInfo
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
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- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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Abstract
The antibacterial oral cavity composition that the invention discloses a kind of containing honeysuckle, product and preparation method thereof, primary raw material is made of Honegsukle flower P.E, galangal rhizome extract, and the mass fraction of its raw material is respectively：0.01-5 parts of Honegsukle flower P.E, 0.01-2 parts of galangal rhizome extract.The technical problem to be solved in the present invention is to provide a kind of alleviation gums a kind of red and swollen, bleeding antibacterial oral cavity composition containing honeysuckle, product and preparation method thereof.
Description
Technical field
The present invention designs a kind of oral-cavity article composition, and in particular to a kind of antibacterial oral cavity composition containing honeysuckle,
Product and preparation method thereof.
Background technology
Gingivitis is the active chronic inflammation for being happened at gingiva tissue, and Chinese medicine is commonly referred to as " gum excessive internal heat ", shows as tooth
Gum redness, bleeding or even pain are uncomfortable, such as intervene or treat not in time, it will lead to more serious periodontal disease, further go out
Existing tooth even falls off, and pain is not accommodated to be brought to patient's daily life.
Honeysuckle is caprifoliaceae plant, is a kind of common clearing heat and removing internal heat Chinese herbal medicine, its major function be it is clearing heat and detoxicating,
Dispelling wind and heat from the body.It is chiefly used in easily getting ecited, the treatments such as warm disease heating, toxic-heat and blood stasis, anemopyretic cold.Currently, the extract of honeysuckle
It is widely used in toothpaste so that toothpaste has clearing heat and removing internal heat, anti-inflammatory analgetic and removes halitosis effect.
Zingiber Alpinia plants galangal possesses long use and medicinal history in China, for plantation, abundance, valence
Lattice are cheaper than propolis, and have effects that mild, cold dispelling, analgesic, spasmolysis, for treating coldness and pain in the epigastrium, vomiting, toothache etc..It is high
Treatment and health care of the galingal as compound Chinese herbal medicinal ingredients for mouth disease have history of more than one thousand years.Modern pharmacology research
Show that there is the flavonoids such as galangal contained in galangal rhizome extract antibacterial, anti-inflammatory, antiviral and analgesia to make
With, but unlike the propolis simultaneously containing brass ingredient contains sensitization source.Wu Qinghe et al.,《Chinese medicine》Magazine, 2000
The o. 11ths of volume 23, the 699-700 pages report, the active constituent that analgesic activity is played in galangal rhizome extract are galangal and mountain naphthalene element
Equal flavone compounds.
Although Honegsukle flower P.E and galangal rhizome extract are the raw materials used in toothpaste, at present not
There are Honegsukle flower P.E and galangal rhizome extract combination application in oral cavity composition.Therefore, inventor carries out the oral cavity use of the two
Product are researched and developed, and during research and development, are studied the proportioning of Honegsukle flower P.E and galangal rhizome extract, it is found that honeysuckle carries
It is research and development the technical issues of needing to overcome to take the proportioning of object and galangal rhizome extract, with compare the stability of toothpaste, mouthfeel and
Effect has an impact, and by the research and development of inventor, overcomes problem above, obtains one kind and can reach prevention and treatment mouth disease,
Better anti-inflammatory, antibacterial and analgesic effect can be played, the antibacterial oral compositions containing honeysuckle of gingivitis and periodontosis are alleviated
Object.
Invention content
Present invention solves the technical problem that provide a kind of alleviation oral inflammation, gum redness, one kind of bleeding contain gold and silver
Colored antibacterial oral cavity composition, product and preparation method thereof.
The present invention a technical solution be：A kind of antibacterial oral cavity composition containing honeysuckle, primary raw material is by gold and silver
Flower extract, galangal rhizome extract composition, and the mass fraction of its raw material is respectively：0.01-5 parts of Honegsukle flower P.E, Gao Liang
0.01-2 parts of ginger extract.
Using a kind of honeysuckle composition of technical solution of the present invention, inventor has found under study for action, Honegsukle flower P.E
With the exclusive use of galangal rhizome extract, it is unable to reach the optimum efficiency that the two is used cooperatively, and the relationship of its proportioning and effect
In nonlinear trend, therefore, after inventor has done a large amount of experimental study, proportion relation as above is obtained, has compared gold and silver
Flower extract, galangal rhizome extract be used alone comparative example oral-cavity article for, have it is more preferably antibacterial, pre- preventing parodontitis,
The effect of gingivitis.
Further, the mass fraction of raw material is respectively：0.01-1 parts of Honegsukle flower P.E, galangal rhizome extract 0.01-
0.5 part.The above proportioning, fungistatic effect is excellent and stability is high, at low cost.
The present invention provides another technical solution：The product of antibacterial oral cavity composition containing honeysuckle, including toothpaste.
The present invention provides another technical solution：The product of antibacterial oral cavity composition containing honeysuckle, including mouthwash.
The present invention provides another technical solution：The product of antibacterial oral cavity composition containing honeysuckle, including chewing gum or
Gel.
Further, the primary raw material mass fraction of the toothpaste is：0.05 part of Honegsukle flower P.E, galangal rhizome extract
0.05 part；Or 0.5 part of Honegsukle flower P.E, 0.1 part of galangal rhizome extract；Or 0.5 part of Honegsukle flower P.E, galangal carry
Take 0.5 part of object.Toothpaste effect is good, stability is good, and at low cost, mouthfeel does not stimulate, and Experience Degree is preferable.
Further, the primary raw material mass fraction of the mouthwash is：0.05 part of Honegsukle flower P.E, galangal rhizome extract
0.05 part；Or 0.1 part of Honegsukle flower P.E, 0.05 part of galangal rhizome extract；Or 0.5 part of Honegsukle flower P.E, galangal
0.1 part of extract.Effect is good, at low cost, and mouthfeel does not stimulate, and Experience Degree is preferable.
Further, the Honegsukle flower P.E purity is 1600-1700ppm；The galangal rhizome extract purity is
More than 96%.
The present invention provides another technical solution：The preparation method of toothpaste is：Its operating procedure includes：
Moisturizer is added in the first step, adds adhesive, stirs homogeneous, and flavoring agent, honeysuckle extraction are added again
Object, galangal, surfactant, and uniform stirring；
Second step is vacuumized after rubbing agent is added, is stirred evenly；
Third walks, and essence is added, and stirs homogeneous, degassing, and prepared by toothpaste completes.
The present invention provides another technical solution：The preparation method of mouthwash is：Its operating procedure includes：
The first step：Water, moisturizer, Honegsukle flower P.E, galangal rhizome extract and sweetener are mixed into water phase；
Second step：It adding essence, preservative, stabilizer to be uniformly mixed, water phase is added in whipping process, filtering dispenses,
Prepared by mouthwash completes.
Specific implementation mode
One：1~embodiment of embodiment 37 is the toothpaste Examples of the antibacterial oral cavity composition of the invention containing honeysuckle, comparison
1~comparative example of example 9 is the comparative example of the toothpaste of the antibacterial oral cavity composition containing honeysuckle of the invention, the composition of raw material and
Ratio is as shown in table 1, unit g, and the raw material total amount of each embodiment is 100g：
Table 1
Now by taking embodiment 1 as an example, a kind of specifically preparation method of bright toothpaste of oral-cavity article containing honeysuckle：
Operating procedure is：
The first step, moisturizer glycerine 10g add thickener sodium carboxymethylcellulose 0.6g, quickly stir evenly, then according to
Secondary addition sorbierite 50g, saccharin sodium 0.3g, Honegsukle flower P.E 0.01g, galangal rhizome extract 0.05g, surfactant 12
Sodium alkyl sulfate 1.2g, preservative sodium benzoate 0.25g and water 13.73g, and stir evenly；
Second step vacuumizes and rubbing agent silica 23g is added, stirs evenly；
Third walks, and essence is added, is strawberry essence 0.9g in the present embodiment, can also be substituted certainly with other essence, to production
Product are stirred evenly without influence, and degassing, toothpaste completes.
2~embodiment of embodiment 37,1~comparative example of comparative example 9, with embodiment 1 in addition to the raw material stage not added is omitted
Outside, remaining operating method is consistent.
Experiment one, bacteriostatic test
Candida albicans are fungies, and oral cavity flora imbalance or individual immunity power can be caused to reduce.And porphyromonas unit cell
Bacterium is the main bacteria for causing periodontitis, and the toothpaste of Examples 1 to 37, comparative example 1~11 in table 1 is assessed using disk diffusion method
To the antibacterial potentiality of Candida albicans and porphyromonas gingivalis.Operating procedure is as follows：Cultivation there is into porphyromonas unit cell respectively
A concentration of 1.0x10 of bacterium and Candida albicans6CFU/mL bacteria suspensions are applied to BHIA and Sabouraud with oese picking uniform crossover
On agar, totally 14.The toothpaste of above-described embodiment 1~37, comparative example 1~11 will be spread evenly across directly with paste 50mg respectively
Diameter is 6, each toothpaste on the roundlet filter paper of 6mm.A kind of sequin filter paper of toothpaste will be coated with and be divided into two groups, each tablet
3, same toothpaste is pasted, then pastes negative control and positive control is each a piece of, during every group is symmetrically attached on culture medium respectively
Between position.Finally culture dish is placed in 37 DEG C of constant temperature incubator for 24 hours, then observed as a result, measuring antibacterial circle diameter.Repeat 3
Secondary experiment, using 3 average values as bacteriostatic diameter, the results are shown in Table 2：
Table 2
As shown in Table 2, embodiment 1-32, as Honegsukle flower P.E, galangal rhizome extract mass fraction gradually increase,
Fungistatic effect is incremented by, but embodiment 15,22,29 nonlinear fungistatic effect occurs and reduces phenomenon；It can be seen that working as honeysuckle
The content of extract between 0.1~0.5, the content of galangal rhizome extract between 0.1~0.5, with Honegsukle flower P.E,
Galangal rhizome extract mass fraction gradually increases, and fungistatic effect can be incremented by, still, not linear to be incremented by.Also, in gold and silver
Flower extract, galangal rhizome extract content at 0.5 or more, there is stable gentle growth in fungistatic effect；Illustrate both
Content when being higher than 0.5 or more, the influence to antibacterial effect is little, and therefore, in embodiment 33~37, honeysuckle is extracted
The data experiment acquisition density of the content of object, galangal rhizome extract reduces.
Embodiment 33~35, when the content of Honegsukle flower P.E is 1g, a little higher than embodiment of fungistatic effect of embodiment 34
33, but the fungistatic effect of embodiment 34 is suitable with the fungistatic effect of embodiment 35, illustrates that the content of Honegsukle flower P.E is 1g
When, in 0.5g or more, fungistatic effect tends to be steady the content of galangal.
Embodiment 36,37, when the content of Honegsukle flower P.E is 2,5g, the content of galangal rhizome extract is chosen for 1,2g
When, (why galangal rhizome extract choose 1,2g, without choose 0.01,0.05 or 0.1g, be because Honegsukle flower P.E with
Ratio problems between galangal rhizome extract, if the content of Honegsukle flower P.E is significantly larger than galangal rhizome extract, drug effect
Aspect, the effect unobvious of the two, and it is more the effect of Honegsukle flower P.E, happened in order to avoid such),
The fungistatic effect of embodiment 36,37 and the fungistatic effect difference of embodiment 34,35 are little, and still, the toothpaste of embodiment 36,37 goes out
Reveal water phenomenon, stability decreases, but does not influence its use, can influence to preserve the service life, 1~embodiment of embodiment 37
Fungistatic effect is above 1~comparative example of comparative example 7.
The content of the Honegsukle flower P.E of comparative example 1~4 is 0, and the content of the galangal rhizome extract of comparative example 5~7 is 0,
Honegsukle flower P.E is not added or any raw material of galangal rhizome extract, fungistatic effect are below the antibacterial of Examples 1 to 37
Effect, illustrates Honegsukle flower P.E and galangal rhizome extract, and it is bad that the two is used alone its effect, both is only used cooperatively
Shi Xiaoguo just can reach most preferably.
Comparative example 8~11 is that the mass fraction of Honegsukle flower P.E is higher than the mass parts of 5.1 or galangal rhizome extract
When number is higher than 2.1, fungistatic effect and the fungistatic effect of embodiment 34~37 are not much different, but it serious discoloration occurs, goes out
Water problems, stability is poor, is unable to reach decomposition, can not use.
Therefore, the mass fraction of toothpaste its raw material of the antibacterial oral cavity composition as the present invention containing honeysuckle is that honeysuckle carries
When taking 0.01-5 parts of object, 0.01-2 parts of galangal rhizome extract, fungistatic effect is preferable, when the mass fraction of its raw material is gold and silver
When 0.05-1 parts of flower extract, 0.05-1 parts of galangal rhizome extract, fungistatic effect is best, and optimal stability, it is contemplated that production
The cost problem of product, it is practical in use, the mass fraction of its raw material is 0.05-0.5 parts of Honegsukle flower P.E, galangal extraction
0.05-0.1 parts of object is optimum proportioning.
In addition, inventor has found, no matter in embodiment either comparative example in the Honegsukle flower P.E of embodiment 4 or
Any of which raw material is continued growing on galangal rhizome extract mass fraction, fungistatic effect variation no longer dramatically increases.Cause
This, in the present embodiment, the raw material proportioning of embodiment 31 is best.
Experiment two：The clinical test of gingivitis
Clinical trial in terms of carrying out gingivitis to toothpaste shown in table 1, every group of 33 people have carried out periodontal inspection before treatment
It surveys, and records grow permanent teeth position, gingival index and dental plaque index.Above subject does conventional clean one's teeth.Deactivate antibiotic, external application
Drug and other toothpaste.It brushes teeth once in the morning and once at night, is maintained at 3min or more every time.Check in 7-14 days is primary, according to above-mentioned finger
Label record.Observed content：Subjective feeling, including bleeding of brushing teeth, hematostaxis, irritation pain, gingival index, plaque refer to
Number, observing time is three months, as a result such as table 3：
Table 3
As can be seen from Table 3：The proportion relation of composition determines therapeutic effect, the treatment of 1~embodiment of embodiment 37
The therapeutic effect with obvious effects for being better than 1~comparative example of comparative example 7；The therapeutic effect of embodiment 1 is substantially better than comparative example 1~comparison
Example 7 illustrates that the effect that a small amount of composition all more single than addition honeysuckle and galangal is added is good；5~comparative example of comparative example 7
Relatively low to the effective percentage for the treatment of gingivitis, the honeysuckle of instruction sheet one does not protrude in the effect for the treatment of gingivitis, and galangal adds
Enter to be used as and have complementary advantages；The effect of 33~embodiment of embodiment 36 is better than 1~embodiment of embodiment 32, this just illustrates gold and silver
Flower extract, galangal rhizome extract only can effectively treat oral cavity gingivitis in specific proportioning, and galangal rhizome extract
Addition can play synergistic effect, and recurrence rate is relatively low after three months.
Two：38~embodiment of embodiment 74 is the mouthwash embodiment of the antibacterial oral cavity composition of the invention containing honeysuckle,
12~comparative example of comparative example 22 is the comparative example of the mouthwash of the antibacterial oral cavity composition of the invention containing honeysuckle, raw material
Composition and ratio it is as shown in table 4, unit g, the raw material total amount of every group of embodiment is 100g：
Table 4
Now by taking a kind of embodiment 38 of the mouthwash of composition containing Honegsukle flower P.E of the present invention as an example, illustrate the system of the present invention
Preparation Method：
Preparation process is as follows：
The first step：By water 79.38g, glycerine 5g, Honegsukle flower P.E 0.01g, galangal rhizome extract 0.01g and sweetener
Saccharin sodium 0.5g is mixed into water phase；
Second step：It adds, (the present embodiment uses grape essence to essence 0.9g, it is also possible to which other essence replace, and do not influence
Product effect), sorbierite 13g, poloxamer 1.2g be uniformly mixed, be slowly added to water phase in whipping process, filtering packing is gargled
Prepared by water completes.
Experiment three：Bacteriostatic test
Select Candida albicans and porphyromonas gingivalis to the embodiment 38-74 of table 4, the mouthwash of comparative example 12~22
Carry out bacteriostatic test, test method according to《Disinfection technology standard》2.1.8.2 it is operated, takes three times repeatedly experiment to have antibacterial
The average value of the bacteriostatic diameter of effect, the results are shown in Table 5：
Table 5
As shown in Table 5, embodiment 38-69, with the gradual increasing of Honegsukle flower P.E, galangal rhizome extract mass fraction
Add, fungistatic effect is incremental；It can be seen that when the content of Honegsukle flower P.E is between 0.1~0.5, galangal rhizome extract contains
Amount is between 0.1~0.5, and as Honegsukle flower P.E, galangal rhizome extract mass fraction gradually increase, fungistatic effect can pass
Increase.
Embodiment 70~74, when the content of Honegsukle flower P.E is more than 1g, fungistatic effect appearance slowly grows steadily
Gesture, a little higher than embodiment 71 of fungistatic effect of embodiment 72~74, difference is little, illustrates that the content of Honegsukle flower P.E is more than 1g
When, in 0.5g or more, fungistatic effect tends to be steady the content of galangal.
The content of the Honegsukle flower P.E of comparative example 12~15 is 0, the content of the galangal rhizome extract of comparative example 16~18
It is 0, does not add Honegsukle flower P.E or any raw material of galangal rhizome extract, fungistatic effect are below embodiment 38~74
Fungistatic effect, illustrates Honegsukle flower P.E and galangal rhizome extract, and it is bad that the two is used alone its effect, both only cooperation
Use Limitation fruit just can reach most preferably.
Therefore, the mass fraction of mouthwash its raw material of the antibacterial oral cavity composition as the present invention containing honeysuckle is honeysuckle
When 0.01-5 parts of extract, 0.01-2 parts of galangal rhizome extract, fungistatic effect is preferable, it is contemplated that the cost problem of product,
It is practical in use, the mass fraction of its raw material is 0.05-1 parts of Honegsukle flower P.E, 0.05-0.5 parts of galangal rhizome extract is
Optimum proportioning.
Inventor has found, no matter to embodiment or comparative example, Honegsukle flower P.E 0.1-0.5 in embodiment and height
Rhizoma Alpiniae Officinarum extract mass fraction 0.1-0.5 is increasing a kind of additive amount of raw material of any of which, and fungistatic effect variation is all unknown
It is aobvious, add the reason of cost.Therefore, the proportioning of the raw material of embodiment 68 is most appropriate in this experiment.
Experiment two：The clinical test of gingivitis
Clinical trial in terms of carrying out gingivitis to mouthwash shown in embodiment 38~74 and comparative example 12~22, every group
33 people, have carried out periodontal inspection before treatment, and record grow permanent teeth position, subjective symptoms, gingival index and plaque index, it is above by
Inspection person does conventional clean one's teeth.Deactivate antibiotic, external used medicine and other effect type mouthwashes.Patient gargles 3 times daily.7-14 days multiple
It looks into once, fills in a form according to These parameters, observed content has：Subjective sensation, including bleeding of brushing teeth, hematostaxis, irritation pain,
Gingival index, plaque index, three months observing times.
As a result such as table 6：
Table 6
As can be seen from Table 6, the proportion relation of composition determines that therapeutic effect, the mass effect of embodiment 38~74 are bright
Treatment of the therapeutic effect better than comparative example 12~18 of the aobvious therapeutic effect better than comparative example 12~18, embodiment 38~51 is imitated
Fruit illustrates to add the composition lacked than the therapeutic effect of single Honegsukle flower P.E or galangal rhizome extract is added
Good, 12~18 pairs for the treatment of gingivitis effective percentage of comparative example are relatively low, illustrate that the addition of Honegsukle flower P.E can improve treatment gum
Scorching effective percentage has complementary advantages with galangal rhizome extract.And the therapeutic effect of comparative example 19~22 more connects with embodiment 66-74
Closely, but honeysuckle or galangal extract concentration are too high, and mouthwash discoloration, stability is poor, and functional component does not decompose.Wherein
The effect of embodiment 59-69 is more preferable, this just illustrates Honegsukle flower P.E and galangal rhizome extract can effectively treat gingivitis, and high
The addition of Rhizoma Alpiniae Officinarum extract can play synergistic effect.So Honegsukle flower P.E, galangal rhizome extract coordinate in certain proportion
It is lower in use, best results, and three months recurrence rates are relatively low.
For those skilled in the art, under the premise of not departing from technical solution of the present invention, if can also make
Dry modification and improvement, these should also be considered as protection scope of the present invention, these all do not interfere with the effect that the present invention is implemented and
Patent practicability.
Claims (10)
1. a kind of antibacterial oral cavity composition containing honeysuckle, it is characterised in that：Its primary raw material is by Honegsukle flower P.E, galangal
Extract forms, and the mass fraction of its primary raw material is respectively：0.01-5 parts of Honegsukle flower P.E, galangal rhizome extract
0.01-2 parts.
2. the antibacterial oral cavity composition according to claim 1 containing honeysuckle, it is characterised in that：The quality of its primary raw material
Score is respectively：0.01-1 parts of Honegsukle flower P.E, 0.01-0.5 parts of galangal rhizome extract.
3. the product of the antibacterial oral cavity composition according to claim 1 containing honeysuckle, it is characterised in that：Including toothpaste.
4. the product of the antibacterial oral cavity composition according to claim 1 containing honeysuckle, it is characterised in that：Including gargling
Water.
5. the product of the antibacterial oral cavity composition according to claim 1 containing honeysuckle, it is characterised in that：Including chewing gum
Or gel.
6. the product of the antibacterial oral cavity composition according to claim 3 containing honeysuckle, it is characterised in that：The toothpaste
Primary raw material mass fraction is：0.05 part of Honegsukle flower P.E, 0.05 part of galangal rhizome extract；
Or 0.5 part of Honegsukle flower P.E, 0.1 part of galangal rhizome extract；
Or 0.5 part of Honegsukle flower P.E, 0.5 part of galangal rhizome extract.
7. the product of the antibacterial oral cavity composition according to claim 4 containing honeysuckle, it is characterised in that：The mouthwash
Primary raw material mass fraction be：0.05 part of Honegsukle flower P.E, 0.05 part of galangal rhizome extract；
Or 0.1 part of Honegsukle flower P.E, 0.05 part of galangal rhizome extract；
Or 0.5 part of Honegsukle flower P.E, 0.1 part of galangal rhizome extract.
8. the product of the antibacterial oral cavity composition according to claim 5 or 6 containing honeysuckle, it is characterised in that：Described
Honegsukle flower P.E purity is 1600-1700ppm；The galangal rhizome extract purity is more than 96%.
9. the article fabrication methods of the antibacterial oral cavity composition according to claim 6 containing honeysuckle, it is characterised in that：Institute
The preparation method for stating toothpaste is：Its operating procedure includes：
Moisturizer is added in the first step, adds adhesive, stirs homogeneous, and flavoring agent, Honegsukle flower P.E, height are added again
Galingal, surfactant and water, and uniform stirring；
Second step is vacuumized after rubbing agent is added, is stirred evenly；
Third walks, and essence is added, and stirs homogeneous, degassing, and prepared by toothpaste completes.
10. the article fabrication methods of the antibacterial oral cavity composition according to claim 7 containing honeysuckle, it is characterised in that：
The preparation method of the mouthwash is：Its operating procedure includes：
The first step：Water, moisturizer, Honegsukle flower P.E, galangal rhizome extract and sweetener are mixed into water phase；
Second step：It adds essence, preservative, stabilizer to be uniformly mixed, water phase is added in whipping process, filtering packing is gargled
Prepared by water completes.
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