CN104983806B - A kind of Chinese medicine composition for treating mouth disease, preparation method and applications - Google Patents
A kind of Chinese medicine composition for treating mouth disease, preparation method and applications Download PDFInfo
- Publication number
- CN104983806B CN104983806B CN201510378502.2A CN201510378502A CN104983806B CN 104983806 B CN104983806 B CN 104983806B CN 201510378502 A CN201510378502 A CN 201510378502A CN 104983806 B CN104983806 B CN 104983806B
- Authority
- CN
- China
- Prior art keywords
- american
- cockroach
- extract
- chinese medicine
- medicine composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Landscapes
- Cosmetics (AREA)
- Medicines Containing Plant Substances (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention discloses a kind of Chinese medicine composition for treating mouth disease, its raw material is made up of following mass fraction：American-cockroach-extract is 0.1~20 part, and it is 0.1~10 part that Bi, which is dialled,.American-cockroach-extract and Bi are dialled and are combined by the present invention, American-cockroach-extract has good musculature repairing activity, the healing of canker sore can be promoted, Bi, which is dialled, has antibacterial action, and Bi dials the signal that can also suppress nerve endings conducting pain, pain of alleviation, oral problem caused by reducing allergy, effect is played with American-cockroach-extract jointly, effectively treats canker sore and hemodia, so as to improve ulcer healing rate, shorten healing.American-cockroach-extract and Bi, which dial the main mechanisms of action, to be myogenic hemostasis, promotes wound healing and its suppress oral bacteria, can fundamentally be treated, will not insulting various immunity functions, be adapted to long-term use.It is more typical medicine that American-cockroach-extract and Bi, which are dialled, and cost is relatively low, is easy to promote.
Description
Technical field
The invention belongs to the technical field of medical science, more particularly to a kind of treat canker sore and the Chinese medicine group of anti-sensitivity of tooth
Compound and its application in oral care implement.
Background technology
Canker sore, commonly referred to as " oral cavity excessive internal heat " or " aphtha " among the people are a kind of using cyclical recurrent as spy
Point the sex-limited ulcerative lesions of oral mucosa office canker sore, can self-healing, can occur at any position of oral mucosa.At present, mouth
The cause of disease and mechanism of causing a disease of chamber ulcer are still indefinite.The inducement of canker sore is probably local trauma, stress, food, medicine
Thing, hormonal readiness changes and vitamin or microelement deficiencies.Because the course of disease is long and pain, often make troubles to patient and pain
It is bitter.
Sensitivity of tooth, it is that tooth is made by environmental stimuli, such as temperature (hot and cold), chemical substance (acid, sweet tea) and machinery
With the symptom of aching caused by (rubbing or sting hard thing) etc., its feature is breaking-out is rapid, pain is sharp, the time is of short duration.It is all to make
Enamel integrality is destroyed, the various dental diseases of dentine exposure, such as abrasion, wedge-shaped defect, odontagma, dental caries and periodontal
Atrophy causes neck portion exposure etc. that dentin hypersensitivity can occur.
American cockroach is a kind of traditional pharmaceutical insects, is Blattaria Blattidae Periplaneta insect, and research shows, American cockroach
Have and promote blood vessel hyperplasia, tissue repair, strengthening heart and boosting pressure, improve microcirculation, it is antimicrobial antiphlogistic, antiviral, it is antitumor, enhancing is immune etc.
Effect, available for skin, oral cavity.Porphyromonas gingivalis is the periodontosis especially most important advantage of adult periodontitis's diseased region
Bacterium, the medicine of periodontosis must effectively suppress periodontal pathogen, and Hu Shaopeng etc. confirms that American-cockroach-extract can be effective
Suppress the growth of porphyromonas gingivalis.Xiao little Qin etc. also demonstrate that American-cockroach-extract to tissue edema caused by inflammation and
Ooze out with obvious inhibiting effect, and have significant analgesic activity, there is anti-inflammation detumescence effect.And American-cockroach-extract carries
Taking technique is ripe, and it also has gratifying prospect in terms of the preventing and treating of periodontal disease, is burst available for auxiliary treatment stomatitis, oral cavity
Ulcer, alveolus alveolitis, extraction complication, periodontitis, chronic periapical periodontitis etc..Publication No. CN102846529A patent of invention
" a kind of toothpaste and preparation method thereof " also discloses that the application of American-cockroach-extract and American-cockroach-extract on toothpaste.
It is a kind of Chinese medicine that Bi, which is dialled, belongs to Piperaceae plant, and it has analgesia, bacteriostasis containing pipering, volatile oil.Bi is dialled
In pipering to housefly nerve and muscle groups be woven with destruction, it is inferred that, it can make dentinal tubule nerve endings
Fiber destruction, disintegration, neurodegeneration, so as to reduce sensitiveness of the dentine to environmental stimuli, play treatment sensitivity of tooth
Effect.At present, the external used medicine for treating dental hypersensitivity is mostly to use chemosynthesis medicine, and Chinese medicine has the effect of unique
The advantages that with toxic side effect less, Chinese medicine is used to treat dental hypersensitivity, can effectively make up the deficiency of the preparations such as fluoride.Mesh
Before, existing Bi appropriations are preferable in the pertinent literature report for the treatment of hemodia, clinical effectiveness.Publication No. CN101933977A's
Patent of invention " Chinese medicine composition and its toothpaste and preparation method of a kind of anti-sensitivity of tooth " disclose with Bi allocate for for mainly into
The Chinese medicine composition and toothpaste divided, there is certain effect to treatment sensitivity of tooth.
The treatment that American cockroach and Bi dial when being used alone to canker sore and dental hypersensitivity has certain effect respectively
Fruit, but come from practical application, its curative effect receives certain limitation.The present inventor guesses whether its reason is because simple
Use cause its drug effect to perform to most preferably, Chinese medicine is when in use, often polyphamaceutic using its is better, therefore
The present inventor expects dialling American cockroach and Bi is combined application according to a certain ratio, to improve its therapeutic effect.And this hair
A person of good sense has found that the patient of canker sore is also frequently accompanied by hemodia.So far, group is dialled on American-cockroach-extract, Bi
Application of the compound in the oral-cavity articles such as toothpaste, mouthwash at home and abroad there is no report.
The content of the invention
The present invention provides a kind of Chinese medicine composition for treating mouth disease, is dialled by adding American-cockroach-extract and Bi,
Reach the purpose for being complementary to one another, cooperateing with each other, have preferable therapeutic action to canker sore and sensitivity of tooth.
In order to solve the above-mentioned technical problem, the present invention provides following technical scheme:A kind of Chinese medicine group for treating mouth disease
Compound, its raw material are made up of following mass fraction：American-cockroach-extract is 0.1~20 part, and it is 0.1~10 part that Bi, which is dialled,.
Present invention employs Chinese medicine to treat canker sore and sensitivity of tooth, and it is rare that Chinese medicine is that Traditional Chinese doctors ' is learnt to read and write
Treasured, generation, the evolution of any disease are all that pathogenic factor acts on human body, and cause body is yin or yang excess to decline partially, zang-fu differentiation
The result of functional disturbance.Bias of medicine mainly have four gas, the five tastes, lifting sink-float, mend let out, channel tropism, toxicity or no toxicity etc..It is if sick
Feelings are more complicated, and single application is difficult to avoid that adverse reaction, generally require the medicine simultaneously using two kinds and its above, can strengthen
Original drug effect, suppress side effect etc., and people have a kind of baffled preference to Chinese medicine.
Compared with prior art, the advantage of the invention is that：1st, American-cockroach-extract and Bi are dialled and are combined, America is big
Lian extracts have good musculature repairing activity, can promote the healing of canker sore, Bi, which is dialled, has antibacterial action, with U.S.
The big Lian extracts in continent have synergy, and Bi dials the signal that can also suppress nerve endings conducting pain, pain of alleviation, reduces allergy
Caused oral problem, effect is played jointly with American-cockroach-extract, canker sore and hemodia are effectively treated, so as to carry
High ulcer healing rate, shorten healing.2nd, American-cockroach-extract and Bi dial the main mechanisms of action be myogenic hemostasis,
Promote wound healing and its suppress oral bacteria, can fundamentally be treated, will not insulting various immunity functions,
It is adapted to long-term use.3rd, it is more typical medicine that American-cockroach-extract and Bi, which are dialled, and cost is relatively low, is easy to promote and makes for a long time
With.
Embodiment
Embodiment 1
The present embodiment is contrast test, by ordinary toothpaste (first group), the toothpaste (second containing American-cockroach-extract
Group), contrasted containing the Bi toothpaste (the 3rd group) dialled and containing American-cockroach-extract and the Bi toothpaste (the 4th group) dialled,
Its formula is as shown in the table：
Table 1
Above-mentioned American-cockroach-extract using American cockroach fine powder, the fineness of American cockroach fine powder more than 200 mesh,
Certainly using the water extract of American cockroach different parts, American cockroach fine powder or the mixing of mentioned component can also be reached to same
The effect of sample.The preparation method of the water extract of adult bombay canary, extracted by the way of first soaking, decoct again, concentrate afterwards；
The preparation method of the alcohol extracting thing of adult bombay canary, take alcohol immersion, the mode of filtering to extract and (extracted on American cockroach
Thing uses and prepared the same the present embodiment of each embodiment).Bi powder allocations fineness (each reality of use on Bi powder allocations more than 200 mesh
Apply the same the present embodiment of example).
The preparation method of above-mentioned toothpaste is as follows：
First group
1st, first glycerine, sorbierite addition are prepared in container, added and sodium carboxymethylcellulose, quickly stir homogeneous.
2nd, saccharin sodium, water, NaLS and sodium benzoate, and uniform stirring are sequentially added.
3rd, vacuumize and add friction-type silica and thickening type silica, stir homogeneous.
4th, essence is eventually adding, stirs homogeneous, degassing, toothpaste is completed.
Second group
Adult bombay canary is added after the step of preparation method of this group is the addition saccharin sodium in first group of preparation method
Alcohol extracting thing.
3rd group
Bi powder allocations are added after the step of preparation method of this group is the addition saccharin sodium in first group of preparation method.
4th group
American cockroach is sequentially added after the step of preparation method of this group is the addition saccharin sodium in first group of preparation method
Adult alcohol extracting thing and Bi powder allocations.
Four groups of toothpaste shown in table 1 are carried out with clinical oral test, 120 with sensitivity of tooth, the people of canker sore
Equal four groups are randomized into, each group of people's number is 30.They (brush the teeth twice daily) on the basis of daily habits makes respectively
With first group, second group, the 3rd group and the 4th group of toothpaste, continue one week, as a result as shown in table 2.
Table 2
From table 2, it will be seen that the 4th group of therapeutic effect controlling significantly better than first group, second group and the 3rd group
Therapeutic effect.This just illustrates that American-cockroach-extract, Bi dial composition and can effectively treat canker sore, alleviate the disease of sensitivity of tooth
Shape.
Embodiment 2
The present embodiment is contrast test, by common mouthwash (first group), the mouthwash (containing American-cockroach-extract
Two groups), (the 4th group) progress of mouthwash for being dialled containing the Bi mouthwashes (the 3rd group) dialled and containing American-cockroach-extract and Bi
Contrast, its formula are as shown in the table：
Table 3
The content of pipering is 50~65% (same the present embodiment of each embodiment of use on Fructus Piperis Longi oil) in Fructus Piperis Longi oil.
The preparation method of above-mentioned mouthwash is as follows：
First group
1st, glycerine, sorbierite, poloxamer, neotame and water are mixed into aqueous phase.
The 2nd, essence is slowly added to above-mentioned aqueous phase while stirring, filtering packing, prepared by mouthwash completes.
Second group
American cockroach is added after the step of preparation method of this group is the addition pair dealcoholysis alcohol in first group of preparation method
Extract.
3rd group
Bi is added after the step of preparation method of this group is the addition pair dealcoholysis alcohol in first group of preparation method to dial.
4th group
America is sequentially added after the step of preparation method of this group is the addition pair dealcoholysis alcohol in first group of preparation method
Big Lian extracts and Bi are dialled.
Four groups of mouthwashes shown in table 3 are carried out with clinical oral test, 120 with sensitivity of tooth, canker sore
People is randomized into equal four groups, and every group of number is 30.They divide on the basis of daily habits (gargling daily three times)
Mouthwash that Shi Yong be first group, second group, the 3rd group and the 4th group, continues one week, as a result as shown in the table.
Table 4
From table 4, it will be seen that the 4th group of therapeutic effect controlling significantly better than first group, second group and the 3rd group
Therapeutic effect.This just illustrates that American-cockroach-extract, Bi dial composition and can effectively treat canker sore, alleviate the disease of sensitivity of tooth
Shape.
Embodiment 3
Containing American-cockroach-extract and the toothpaste component of Bi groups as shown in table 5, table 6 and table 7：
Table 5
Table 6
Table 7
Certainly, during prepared by the lotion of toothpaste, glycerine, sorbierite, propane diols or poly- second two can also be used alone in NMF
Other numbers in addition to 10g, 35g also may be selected in one kind in alcohol, or the mixture using its any combination, mass fraction
Value, number range is in 10~70g；Adhesive can use sodium hydroxyethyl cellulose, sodium carboxymethylcellulose, carragheen,
Xanthans or carbomer single component or compound, mass fraction is in 0.1~10g；Surfactant can use it is cloudy from
The single components such as son, cation, both sexes or nonionic surfactant or mixture, such as lauryl sodium sulfate, lauryl sulphur
Sour sodium, N- sarcosinates, hydramine, poloxamer etc., the mixture of lauryl sodium sulfate, NaLS,
Amount ranges can be 0.1~10g；Sweetener can use saccharin sodium, the sweet tea that sharps teeth, stevioside, stevioside, xylitol
In one or more mixing, 0.1~3g of amount ranges, essence can use peppermint, spearmint oil, American mint, fennel
One or more mixing in fragrant brain, 0.1~5g of amount ranges, preservative use benzoic ether, sodium benzoate, nipalgin
One or more mixtures in methyl esters, 0.1~2g of amount ranges.Selected above is the conventional selection for making toothpaste.
27 groups of mouthwashes shown in table 5, table 6 and table 7 are carried out with clinical oral test, 270 quick with tooth
Sense, the people of canker sore are randomized into equal 27 groups, and every group of number is 10.They are on the basis of daily habits
(gargling daily three times) using the toothpaste of above-mentioned group of number, continues one week, as a result as shown in table 8, table 9 and table 10 respectively.
Table 8
Table 9
Table 10
From table 8-table 10 it can be seen that：1st, when the quality of American cockroach fine powder is at 0.1-20 grams, Fructus Piperis Longi oil is (in Fructus Piperis Longi oil
The content of pipering is 50~65%) quality at 0.1-10 grams, have to canker sore and hemodia and preferably alleviate
Effect, when the mass range of American cockroach fine powder and Fructus Piperis Longi oil is outside above range, total to canker sore and hemodia
Remission effect is poor.2nd, when the quality of American cockroach fine powder is at 4-10 grams, the quality of Fructus Piperis Longi oil compares America at 0.4-1 grams
The quality of big Lian fine powders is at 1-20 grams, and the quality of Fructus Piperis Longi oil is at 0.1-10 grams, the alleviation total to canker sore and hemodia
Effect is more preferable.3rd, when the quality of American cockroach fine powder is at 5-7 grams, the quality of Fructus Piperis Longi oil is at 0.5-0.7 grams, and American cockroach is thin
The ratio of powder and Fructus Piperis Longi oil is 10:When 1, other proportionings are more than to the remission effect of canker sore and hemodia to canker sore
With the remission effect of hemodia.4th, when the quality of American cockroach fine powder is at 6 grams, the quality of Fructus Piperis Longi oil is at 0.6 gram, effect
To be optimal.
Embodiment 4
The water constituent of gargling dialled containing American-cockroach-extract and Bi is as shown in the table：
Table 11
Table 12
Table 13
Wherein, the fineness of American cockroach fine powder is more than 200 mesh, and the content of pipering is 50~65% in Fructus Piperis Longi oil.
27 groups of mouthwashes shown in table 11-13 are carried out with clinical oral test, 270 with sensitivity of tooth, mouth
The people of chamber ulcer is randomized into equal 27 groups, and every group of number is 10.They are (every on the basis of daily habits
It is gargled three times) respectively using the mouthwash of above-mentioned group of number, continue one week, it is as a result as shown in the table.
Table 14
Table 15
Table 16
Wherein, the fineness of American cockroach fine powder is more than 200 mesh, and the content of pipering is 50~65% in Fructus Piperis Longi oil.
It can be seen that from table 14-16：1st, when the quality of American cockroach fine powder is at 0.1-20 grams, Fructus Piperis Longi oil is (in Fructus Piperis Longi oil
The content of pipering is 50~65%) quality at 0.1-10 grams, have to canker sore and hemodia and preferably alleviate
Effect, when the mass range of American cockroach fine powder and Fructus Piperis Longi oil is outside above range, total to canker sore and hemodia
Remission effect is poor.2nd, when the quality of American cockroach fine powder is at 4-10 grams, the quality of Fructus Piperis Longi oil compares America at 0.4-1 grams
The quality of big Lian fine powders is at 1-20 grams, and the quality of Fructus Piperis Longi oil is at 0.1-10 grams, the alleviation total to canker sore and hemodia
Effect is more preferable.3rd, when the quality of American cockroach fine powder is at 5-7 grams, the quality of Fructus Piperis Longi oil is at 0.5-0.7 grams, and American cockroach is thin
The ratio of powder and Fructus Piperis Longi oil is 10:When 1, other proportionings are more than to the remission effect of canker sore and hemodia to canker sore
With the remission effect of hemodia.4th, when the quality of American cockroach fine powder is at 6 grams, the quality of Fructus Piperis Longi oil is at 0.6 gram, effect
To be optimal.
For those skilled in the art, toothpaste and mouthwash are considered the more applicable mouth of technical solution of the present invention
Chamber articles for use, but the present invention is not limited in being added into toothpaste and mouthwash, in tooth powder, tooth paste or ointment preparation, tooth
Other oral-cavity articles such as gel and chewing gum are equally applicable.Without departing from the inventive concept of the premise, if can also make
Dry modification and improvement, these should also be considered as protection scope of the present invention, these all without influence effect that the present invention implemented and
Practical applicability.
Claims (8)
1. a kind of Chinese medicine composition for treating mouth disease, it is characterised in that its raw material is made up of following mass fraction：America is big
Lian fine powders are 0.1~20 part, and Fructus Piperis Longi oil is 0.1~10 part, wherein, the content of pipering is 50~65% in Fructus Piperis Longi oil.
2. the Chinese medicine composition for the treatment of mouth disease as claimed in claim 1, it is characterised in that its raw material is by following mass parts
Array into：American cockroach fine powder is 4~10 parts, and Fructus Piperis Longi oil is 0.5~1 part.
3. the Chinese medicine composition for the treatment of mouth disease as claimed in claim 2, it is characterised in that its raw material is by following mass parts
Array into：American cockroach fine powder is 5~7 parts, and Fructus Piperis Longi oil is 0.5~0.7 part.
4. the Chinese medicine composition for the treatment of mouth disease as claimed in claim 3, it is characterised in that its raw material is by following mass parts
Array into：American cockroach fine powder is 6 parts, and Fructus Piperis Longi oil is 0.6 part.
A kind of 5. oral care implement of the Chinese medicine composition containing as any one of claim 1-4, it is characterised in that
The form of oral care implement is toothpaste, mouthwash, tooth powder, tooth paste, tooth gel and chewing gum.
6. oral care implement as claimed in claim 5, it is characterised in that the lotion of the toothpaste includes NMF, friction
Agent, adhesive, surfactant, sweetener, essence, preservative and water.
7. oral care implement as claimed in claim 5, it is characterised in that the raw material of the mouthwash include NMF, water,
Sweetener, poloxamer and essence.
8. the preparation method of toothpaste in a kind of oral care implement as claimed in claim 6, it is characterised in that including following step
Suddenly：
The first step, add NMF, add adhesive and quickly stir homogeneous, sequentially add sweetener, American-cockroach-extract,
Bi is dialled, surfactant, preservative, and uniform stirring；
Second step, addition rubbing agent is vacuumized, stir homogeneous；
3rd step, essence is added, stir homogeneous, degassing, toothpaste completes.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510378502.2A CN104983806B (en) | 2015-07-01 | 2015-07-01 | A kind of Chinese medicine composition for treating mouth disease, preparation method and applications |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510378502.2A CN104983806B (en) | 2015-07-01 | 2015-07-01 | A kind of Chinese medicine composition for treating mouth disease, preparation method and applications |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104983806A CN104983806A (en) | 2015-10-21 |
| CN104983806B true CN104983806B (en) | 2018-03-23 |
Family
ID=54295795
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510378502.2A Active CN104983806B (en) | 2015-07-01 | 2015-07-01 | A kind of Chinese medicine composition for treating mouth disease, preparation method and applications |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104983806B (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107375168A (en) * | 2017-07-22 | 2017-11-24 | 李映波 | A kind of anti-caries toothpaste of American-cockroach-extract-containing |
| CN108578336A (en) * | 2018-02-13 | 2018-09-28 | 云南宁康生物科技有限公司 | A kind of gargle and preparation method thereof containing American-cockroach-extract |
| CN113456567A (en) * | 2021-04-30 | 2021-10-01 | 唐山青木生物科技有限公司 | Periplaneta americana mouthwash and preparation method thereof |
| CN114376956A (en) * | 2022-02-24 | 2022-04-22 | 四川天福精细化工有限公司 | Spray mouth wash and preparation method thereof |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101254212A (en) * | 2008-03-25 | 2008-09-03 | 浙江大学 | Use of valid target of periplaneta americana |
| CN101837045A (en) * | 2010-05-25 | 2010-09-22 | 耿福能 | American cockroach medicinal composition for curing oral ulcers and preparation method thereof |
| CN101837019A (en) * | 2010-05-25 | 2010-09-22 | 耿福能 | American cockroach medicinal composition for curing oral ulcers and preparation method thereof |
| CN101837018A (en) * | 2010-05-25 | 2010-09-22 | 耿福能 | American cockroach medicinal composition for curing ulcers or ulcerative inflammation and preparation method thereof |
| CN102846529A (en) * | 2012-08-31 | 2013-01-02 | 耿福能 | Toothpaste and preparation method thereof |
| CN103690457A (en) * | 2012-08-31 | 2014-04-02 | 耿福能 | Toothpaste and preparation method thereof |
-
2015
- 2015-07-01 CN CN201510378502.2A patent/CN104983806B/en active Active
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101254212A (en) * | 2008-03-25 | 2008-09-03 | 浙江大学 | Use of valid target of periplaneta americana |
| CN101837045A (en) * | 2010-05-25 | 2010-09-22 | 耿福能 | American cockroach medicinal composition for curing oral ulcers and preparation method thereof |
| CN101837019A (en) * | 2010-05-25 | 2010-09-22 | 耿福能 | American cockroach medicinal composition for curing oral ulcers and preparation method thereof |
| CN101837018A (en) * | 2010-05-25 | 2010-09-22 | 耿福能 | American cockroach medicinal composition for curing ulcers or ulcerative inflammation and preparation method thereof |
| CN102846529A (en) * | 2012-08-31 | 2013-01-02 | 耿福能 | Toothpaste and preparation method thereof |
| CN103690457A (en) * | 2012-08-31 | 2014-04-02 | 耿福能 | Toothpaste and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN104983806A (en) | 2015-10-21 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2004083443A (en) | Composition using mastic for preventing and treating periodontal disease and method for preventing and treating periodontal disease | |
| US5378465A (en) | Solution for application to an oral cavity | |
| KR101955468B1 (en) | Preparing method for toothpaste composition comprising natural extracts | |
| CN106924106B (en) | Toothpaste for inhibiting dental plaque and relieving gingival inflammation | |
| CN104983806B (en) | A kind of Chinese medicine composition for treating mouth disease, preparation method and applications | |
| US20120288454A1 (en) | Dental protection toothpaste composition | |
| WO2014196947A1 (en) | Multifunctional toothpaste | |
| CN109223663A (en) | A kind of Chinese herbal toothpaste and preparation method thereof for gingivitis | |
| CN109276475A (en) | One kind Chinese medicinal toothpaste containing bletilla polysaccharide and preparation method thereof | |
| CN108938501A (en) | Chinese medicine composition and oral care product applied to oral care product | |
| CN108078871B (en) | A kind of mouthwash of the rare saponin(e containing Radix Notoginseng and preparation method thereof | |
| WO2016010284A1 (en) | Toothpaste composition containing curcuma longa l., and preparation method therefor | |
| KR101216427B1 (en) | Calendula officinalis dentifrice composition and process for preparing the same | |
| CN104983744A (en) | Oral care composition containing periplaneta americana, oral care products and preparation methods of oral care composition and oral care products | |
| CN106377481B (en) | A method for extracting rhizoma Cyperi extract, and toothpaste and collutory containing the same | |
| CN101007088A (en) | A traditional Chinese medicine composition for treating periodontal diseases and its preparation method | |
| CN108420768A (en) | A kind of shield gum toothpaste of anti-inflammation hemostasia and preparation method thereof | |
| CN103599182A (en) | Traditional Chinese medicine composition and preparation method thereof, and oral cavity cleaning and nursing product and preparation method thereof | |
| KR102171798B1 (en) | Composition for treating oral disease and inhibiting halitosis containing natural extracts and preparation method therefor | |
| KR101916377B1 (en) | Composition for teeth whitening and preparation method therefor | |
| RU2334522C1 (en) | Medicinal and preventive elixir for oral cavity care | |
| CN106176315A (en) | A kind of collutory and preparation method thereof | |
| JP3389556B2 (en) | Composition for preventing or treating periodontal disease | |
| CN104224981A (en) | Traditional Chinese medicine composition for improving gum and periodontal health and toothpaste containing same | |
| Raj et al. | Herbal mouthwash. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |