WO2014196947A1

WO2014196947A1 - Multifunctional toothpaste

Info

Publication number: WO2014196947A1
Application number: PCT/UA2014/000060
Authority: WO
Inventors: Валерий Валентинович ПРАВДИН; Владимир Владимирович КАПУСТИН
Original assignee: Pravdin Valeriy Valentinovch; Kapustin Vladimir Vladimirovich
Priority date: 2013-06-07
Filing date: 2014-06-10
Publication date: 2014-12-11
Also published as: RU2014105805A

Abstract

The invention relates to the field of medicine, and more particularly to dentistry, and can be used as a dental and oral cavity hygiene agent and as a healing and prophylactic dental agent. A mutlifunctional toothpaste comprising a base that includes an abrasive material, a shape-giving thickening agent, a humectant, a cleansing and foaming agent, a sweetening agent, active substances, and a solvent, and additionally comprising a phytobase, wherein the active substances are in the form of a phytoactive agent based on plant products that are selected taking into account a comprehensive individualized approach to oral problems, with the following ratio of ingredients : 50-70 wt%. base; 0.1-2.5 wt.% phytobase; 1.0-3.8 wt.% phytoactive agent; and the remainder solvent. This multifunctional toothpaste provides high-quality professional hygiene care for the teeth and gums, without side effects, based on a comprehensive individualized approach to oral problems.

Description

MULTIFUNCTIONAL DENTAL PASTE The invention relates to medicine, namely to dentistry, and can be used as a means for hygiene of teeth and oral cavity and as a therapeutic and prophylactic dental product.

A promising direction in the field of production of toothpastes is the development of complex-action toothpaste formulations that not only effectively clean the surface of the teeth, but also have a prophylactic and therapeutic effect on the tissues of the oral cavity and at the same time have a pleasant taste and smell.

Known therapeutic toothpaste [1] for the treatment of inflammatory diseases of periodontal and oral mucous membranes, containing as active component peptides associated with phospholipids obtained from cod liver, in a quantitative ratio, wt.%: Peptides 40-99 and phospholipids 1-60. The content of peptides in the composition of the toothpaste ranges from 0.01 to May 5.0. % Toothpaste contains until May 65th. % of the base, including abrasive material, a forming thickener, a water-retaining substance, a cleaning and foaming component, a preservative, a dye, perfume, and also a solvent such as purified water at a certain ratio of components. Treatment-and-prophylactic toothpaste may additionally contain an antioxidant, sweetener, and plant extract in the amount of May 0.1-5.0. %, fluorides and / or desensitizing agent. In this case, silicon dioxide is used as an abrasive material, polyethylene glycol of various molecular weights is used as a shaping thickener, sorbitol and glycerin are used as a water-retaining substance, sodium lauryl sulfate or sodium laureth sulfate, for example, nipagin are used as a preservative, colorant and perfume selected from the group of pharmaceutically acceptable and approved for use in the composition of toothpastes dyes, for example, titanium dioxide, and flavoring agents, for example, such as a mint fragrance, and water is used as a solvent.

The use of paste improves the condition of periodontal tissues and the oral cavity, relieves inflammatory processes, reduces bleeding, and soreness of the gums. The paste has a healing effect, accelerates reparative processes, improves trophic tissue, does not have a side effect, does not cause allergic reactions and can be used at any age regardless of the presence of concomitant diseases. The main anti-inflammatory component in the known toothpaste are peptides associated with phospholipids obtained from cod liver taken in a certain ratio.

However, this toothpaste does not take into account the individual characteristics of the oral cavity state of a particular patient and is not multifunctional. In addition, the composition of the toothpaste includes a cleaning and foaming component such as sodium lauryl sulfate or sodium laureth sulfate, which are surface-active substances and can cause carcinogens and allergic reactions with prolonged use.

Known toothpaste for the prevention of caries [2], containing a base including a foaming agent, an abrasive component, a binder and a colored component, while it contains sodium lauryl sulfate as a foaming agent, the abrasive component is chalk, chemically precipitated, or dicalcium phosphate dihydrate or silicon dioxide or titanium dioxide, the binder is sodium carboxymethyl cellulose or methyl cellulose, and the color component is a food coloring or juices, or extracts of berries and vegetables, for example yaemye in the food industry for coloring, while additionally contains humectants as glycerin and / or sorbitol, biological additives, which are saccharin, essential oils of plants or hydroalcoholic extracts of medicinal plants, as well as preservatives and flavoring components at a certain ratio.

During toothbrushing, toothpaste stains areas with microcracks, tartar, beginning caries, which allows you to control the degree of cleaning of the oral cavity at home, diagnose caries in the early stages and detect microcracks and tartar.

However, this toothpaste does not take into account the individual characteristics of the oral cavity and does not provide a sufficient preventive effect.

In addition, the use of toothpaste with prolonged use can cause the formation of carcinogens, due to the fact that the composition of the toothpaste includes a cleaning and foaming component such as sodium lauryl sulfate or sodium laureth sulfate, which are surfactants.

Closest to the claimed solution is a toothpaste [3] containing a base comprising an abrasive material, a shaping thickener, a water-retaining substance, a cleaning and foaming substance, a sweetener, active substances and a solvent. Moreover, as an active substance, the paste contains mexido (2-ethyl 6-methyl 3-hydroxypyridine succinate) and calcium citrate in the following ratio, May. %:

Abrasive material 7.0 - 30.0

shaping thickener 0.2 - 2.0

Preservative 0.05 - 0.2

Dye 0.001-1.0

water-retaining substance 15.0 - 80.0

cleansing and foaming 0.1 - 5.0

component

Sweetener 0.05 - 0.2

Fragrance 0.1 - 1.5

Mexidol 0.1 - 10.0

Calcium Citrate 0.1 - 5.0

Water rest

In this case, silicon dioxide is used as an abrasive material, carboxymethyl cellulose derivatives are used as a shaping thickener, glycerol and / or sorbitol are used as a water-retaining substance, sodium lauryl sulfate is used as a cleaning and foaming agent, xylitol or saccharin are used as a sweetener, and xylitol or saccharin are used as a sweetener. substances - Mexidol, and water is used as a solvent.

The use of paste leads in a short time to a significant improvement in the condition of periodontal tissues and the oral cavity. Rapid elimination of the inflammatory process, a decrease in edema, bleeding, and soreness of the gums, due to the use of Mexidol, are noted. The paste has a healing effect, accelerates reparative processes, improves trophic tissue. However, the known toothpaste does not provide the possibility of its long and safe use, which is due to the fact that the toothpaste contains such a cleaning and foaming component as sodium lauryl sulfate, which with prolonged use can cause such a side effect as the formation of carcinogens.

In addition, a preservative is used in the composition of this paste, such as sodium benzoate, methyl paraben or other similar chemical components that increase the shelf life of the toothpaste, but can cause allergic reactions.

It should also be noted that the use of Mexidol can also cause allergic reactions.

The basis of the invention is the task of creating such a multifunctional toothpaste, in which by using natural components taken in a certain ratio and taking into account a comprehensive individual approach to oral problems, high-quality hygienic and professional care of teeth and gums is achieved without side effects.

The problem is solved in that in a known toothpaste containing a base comprising an abrasive material, a shaping thickener, a water-retaining substance, a cleaning and foaming substance, a sweetener, active substances and a solvent, according to the invention, additionally contains phyto base, the active substance contains phytoactive based on plant components, selected taking into account a comprehensive individual approach to oral problems, with the following ratio of components, in May. %:

Base 50-70

Phyto base 0.1-2.5

Phytoactive 1.0-3.8

Solvent rest

In addition, the phyto base is selected from the group including sage tincture, grapefruit seed extract and extract of a mixture of medicinal plants such as chamomile, calendula, yarrow. In this case, the phytoactive is selected from the group including extracts of medicinal plants, essential oils, biologically active liquids from food and medicinal plants, as well as sea salt. In addition, herbal extracts of the phytoactive plant are selected from the group consisting of aloe vera extract, oil extract of amaranth seeds, oil extract of seeds and root vegetables of carrots, oil extract of rose hips, extract of echinacea, extract of hop cones, oil extract of thyme grass, oil extract of juniper berries, chaga extract, green tea leaf extract, comfrey root extract, hearty macklea shoot extract, clover oil extract, eucalyptus oil extract, plantain leaf extract, oil extract celandine tract, St. John's wort herb extract.

In addition, the phytoactive essential oils are selected from the group including mint, basil, lemon balm, oregano, tea tree, nutmeg, fir, lavender.

In addition, biologically active phytoactive fluids are selected from the group consisting of pine needles, cabbage leaves, common mountain ash fruits, chokeberry fruits, calamus marsh, plantain leaves, elecampane root, rose hips, carrot root vegetables, lemon fruits, burdock root, cranberry berries and celandine grass.

It is advisable when polyvinylpyrrolidone and xanthan gum are selected as the shaping thickener. At the same time, silicon dioxide and titanium dioxide were selected as abrasive and bleaching material.

In addition, glycerin and sorbitol were selected as a water-retaining substance.

Cocamidopropyl betaine was selected as a cleaning and foaming agent.

As a sweetener, sodium saccharin was selected. In addition, the base contains a pH regulator and stabilizer selected from the group consisting of potassium nitrate and sodium phosphate.

At the same time, a biologically active liquid (BAL) of nettle leaves and / or water, or nettle hydrolate, or nettle hydrolate and water was chosen as a solvent.

As you know, there is a direct correlation between poor oral hygiene and periodontal disease, caries. According to modern research, the most practical and quite effective method of preventing many dental diseases is regular brushing with a toothbrush and toothpaste in the recommended mode.

Moreover, the rate of plaque formation and its localization, in the absence of oral hygiene, depends on the individual characteristics of a person, diet, saliva secretion and its composition.

The results of the analysis of clinical, laboratory and experimental studies indicate the feasibility of using local hygienic and professional oral care products. Of particular relevance is the issue of the use of individual oral care products.

The effectiveness of treatment programs in dentistry depends on the selection of toothpaste. The quality of the toothpaste depends on the formulation of the constituent ingredients of the toothpaste, the effect on all links of pathogenesis. Toothpastes carry out not only a professional approach to hygiene, but also activate the therapeutic effect against possible diseases of the oral cavity - caries and inflammatory diseases: periodontitis, gingivitis, stomatitis.

A distinctive feature of the proposed multifunctional toothpaste is its full natural origin, i.e. phyto base and phytoactive toothpastes consists of the most effective medicinal plants used in dental practice.

Over the past decade, for various reasons around the world, there has been a tendency to use herbal remedies in the treatment of many diseases, including including dental. The balanced use of complex treatment with the use of herbal remedies can give the maximum possible therapeutic and wellness effect. The vegetable components of toothpaste have several advantages over synthetic medicines: this is the possibility of their long and safe use. They rarely cause allergic reactions; adaptation of macro- and microorganisms does not develop to them. By the strength of action and pharmacological activity, herbal medicinal ingredients are not inferior to synthetic agents.

In the proposed toothpaste in phyto-base and phyto-active, vegetable forms from medicinal plants are used, obtained by special technology with preservation of structural capabilities, energy-information potential and medicinal properties of plants. These are oil extracts, extracts, biologically active fluids (BAL), which are intercellular and intracellular fluids obtained from food and medicinal plants.

Numerous experimental and clinical studies of intercellular and intracellular fluid (BAJ) extracted from plants have confirmed that this fluid (BAJ) is biologically active and has a healing effect on the human body.

The phyto base of toothpaste is selected from the group including sage tincture, grapefruit seed extract and extract of a mixture of medicinal plants, such as chamomile, calendula, yarrow.

Sage tincture - refers to a strong disinfectant herbal medicines that can destroy pathogens of infectious diseases.

The pharmacological effect of sage is determined by the tannins and essential oils contained in it. They favorably affect the microflora of pathological gingival pockets, suppressing and inhibiting the growth and reproduction of pathological microflora (antiseptic properties); inhibit the inflammatory process in various phases of its development, contribute to the development of epithelial tissue covering the oral mucosa; prevent the process of protein breakdown when exposed to putrefactive microorganisms (anti-putrefactive effect); protect the mucosa (astringent action); inhibit the development and vital activity of viruses (antiviral effect).

Grapefruit seed extract is a broad-spectrum antiseptic, antifungal, antibacterial natural extract of bioflavonoids, vitamin C, glycosides and protein. It is most effective against museum and clinical strains of Candida fungi. It is superior to Diflucan, Candide, Dekasan in antifungal activity. Thanks to the use of grapefruit seed extract, toothpaste has an antibacterial effect, based on damage to the cytoplasmic membrane, cell wall and inhibiting the synthesis of bacterial amino acids. The extract has antibacterial activity against staphylococci, streptococci and other pathogens, including anaerobic bacteria, which dominate in infections of the oral cavity (gingivitis, ulcers of the mucous membrane, paradental suppuration, with complications after tooth extraction). Due to flavonoids, P-vitamin activity is determined, which eliminates and prevents the increased fragility of capillaries and the permeability of the vascular wall during inflammatory processes, maintaining the structure, elasticity and strength of blood vessels. The extract has a pronounced antioxidant effect.

Extracts of chamomile, calendula, yarrow have pronounced properties to reduce microbial contamination of the oral cavity and the possibility of microorganisms entering the bloodstream; clean the mucous membrane of the products of decay, plaque, mucus, desquamated epithelium; improve the outflow of metabolic products from tissues; stop the clinical manifestations of diseases (pain, bleeding gums, inflammation); normalize trophic mucosa; activate the mechanisms of local immunity of the oral cavity; help strengthen capillaries; reduce leukocyte migration on the surface of the mucosa.

The most important composition in multifunctional toothpastes belongs to the phytoactive. Thanks to the phytoactive agent, which consists of extracts of medicinal plants, essential oils, biologically active liquid from food and medicinal plants, the therapeutic effect is ensured when the diagnosis is made. In this case, the composition of the phytoactive is chosen taking into account a comprehensive individual approach to problems of the oral cavity.

The action of medicinal and food plants included in the phytoactive is designed for high permeability of the oral mucosa for various substances. It has been established that some vitamins, phosphates, calcium, potassium and other biologically active substances penetrate relatively quickly through the mucous membranes of the mouth, tongue, gums and have a beneficial effect on periodontal tissues. In this regard, the use for preventive and therapeutic purposes of special toothpastes, which include vitamins, chlorophyll, micro and macro elements, biologically active substances, is very advisable.

Toothpaste phytoactive is selected from the group including extracts of medicinal plants, essential oils, biologically active liquids (BAL) from food and medicinal plants, as well as sea salt. Herbal extracts of the phytoactive plant are selected from the group consisting of aloe vera extract, oil extract of amaranth seeds, oil extract of seeds and root vegetables of carrots, oil extract of rose hips, extract of echinacea, extract of hop cones, oil extract of thyme grass, oil extract of juniper berries, oil extract of juniper berries, , green tea leaf extract, comfrey root extract, Maclea shoots heart-shaped, clover oil extract, eucalyptus oil extract, plantain leaf extract, pure oil extract He ate grass St. John's wort.

Due to the introduction of the fruits of the mountain ash ordinary, the BAA of pine needles, and the extract of amaranth oil seeds, which are rich in vitamins C, P, E, into the toothpaste BAJ, a significant effect on the reduction of vascular permeability, on the state of metabolic and trophic processes in the tissues of the mucosa and periodontal is provided.

The introduction to the composition of toothpaste - tinctures of sage, aloe vera extract, BAJ of cabbage leaves favorably affects reparative processes in the mucosa, since these substances have an enveloping, astringent, tanning effect, form colloidal complexes with proteins, compact the epithelial layer of the mucous membrane, inhibit the effects of osmosis and exudation.

The introduction of basil essential oil increases the activity of lysozyme in saliva, enhancing the antibacterial effect of toothpaste, which leads to inhibition of pathogenic microflora

The introduction of peppermint essential oil stimulates wound healing. At the same time, peppermint essential oil has a wound healing, anti-inflammatory and deodorizing property.

Introduction to the composition of the BAJ toothpaste of calamus swamp, the BAJ of the leaves of plantain provides an anti-inflammatory effect of the paste. Long-term chronic inflammation is usually accompanied by a significant decrease in the content of vitamins C and P in the oral mucosa, which is eliminated due to the use of aronia fruits, rosehip oil extract, seed oil extract, and carrot root in the toothpaste BAJ.

Rosehip oil extract helps to eliminate lymphoid-plasmacytic infiltrates (desensitizing effect), normalizes the metabolism of nucleoproteins, and resists atrophic changes in the mucosa. In case of erosive, aphthous, and ulcerative lesions of the oral mucosa, the extracts of herbs of antimicrobial, anti-inflammatory, enveloping, keratoplastic, wound healing, anti-ulcer nature are important, for which purpose plantain leaves leaf oil, rosehip oil extract, and rosehip oil, tincture, tincture, and tincture are also added. Seed and root extract of carrots.

To enhance the analgesic effect of sage, lemon balm essential oil is introduced into the composition of the toothpaste.

Yu The introduction of plantain leaf extract into the toothpaste provides effects on pathological gingival pockets and reduces autoaggression in the foci of inflammation, has a pronounced anti-inflammatory effect, stimulates reparative processes in periodontal tissues, reduces purulence, and has enveloping, analgesic properties.

The introduction of the oil extract of the thyme herb, BAJ of elecampane root into the toothpaste composition, has anti-inflammatory, bacteriostatic, hemostatic, detoxification effects.

To eliminate inflammation and eliminate pathological gingival pockets, improve microcirculation in the mucous membranes and gum tissues in the composition of the paste, a combination of BAJs of chestnut fruits and hop cones extract are used. At the same time, the extract of hop cones has an additional analgesic effect (local anesthetic), reduces local autoaggression in the lesion foci.

The use of echinacea extract in the toothpaste enhances local immunity and the protective properties of the mucosa, has an anti-inflammatory, antimicrobial, wound healing effect with an antioxidant effect.

Oil extracts of juniper and thyme herbs have selective antibacterial activity against antibiotic-resistant strains of staphylococcus, reduce swelling of inflamed tissues, and resist pathogenic fungal flora.

The use of essential oil of oregano in the composition of the toothpaste provides antibacterial properties of the toothpaste, eliminates unpleasant odor (deodorizing effect). Due to the fact that the extract of chaga (birch fungus) contains anthocyanidins that form colloidal aqueous solutions, agaricic acid, triterlinoid, inotodiol, resins, the cytostatic effect of toothpaste is provided for hypertrophic gum growths. The introduction of tea tree essential oil into the toothpaste provides an additional anti-inflammatory, wound healing effect.

The introduction of lemon fruits into the toothpaste, due to the content of citric and ascorbic acids, leads to the normalization of the biochemical parameters of saliva, strengthens the mineral structure of enamel and reduces the susceptibility to caries, and activates the processes of remineralization of enamel and dentin. This ensures a reduction in bleeding gums, normalization of redox processes in the gum tissue, and local immunity increases.

Due to the introduction of comfrey root extract into the toothpaste, the regeneration of bone and soft periodontal tissues is enhanced, due to the presence in the comfrey of the allantoin derivative of purine, which is contained in the plant in high concentration, and easily digestible calcium compounds, which help maintain enamel strength and protect it from cariogenic factors.

Due to the use of green tea extract in the toothpaste, which is a natural source of fluorine and tannins, carbohydrate metabolism is restrained and suppressed, acid aggression in the oral cavity is reduced, which helps strengthen the hard tissues of the tooth and, to a certain extent, reduces the risk of tooth decay.

The introduction of nutmeg essential oil in combination with other anti-caries ingredients in the toothpaste helps to significantly reduce the indicators that cause tooth damage, primarily reducing the risk of tooth decay.

Thanks to the introduction of fir essential oil into the toothpaste, the antimicrobial and wound healing effect is enhanced, microcirculation is improved, the regeneration of wound surfaces is accelerated, due to the fact that the chemical composition of fir includes borne acetate, borneol, camphene, etc.

The introduction of burdock root, which is a natural active antibiotic, into the toothpaste BAJ inhibits the growth of gram-positive microorganisms, corrects water-salt metabolism, accelerates the healing of ulcerative defects, stimulates the restoration of connective tissue, limits inflammation in the mouth and gums.

Introduction to the composition of toothpaste of the extract of makleia heart-shaped, which is a natural antibiotic, provides a powerful anti-inflammatory, antiseptic, antimycotic and antiviral effect, which is due to the chemical composition of this plant, which includes a mixture of alkaloids (allocryptopin, sanguinarine, protopine, helerythrin, berberine and. . Maclayia, as an alternative to antibiotics, is especially relevant for infectious and inflammatory diseases of the mucous membrane and gum tissues of bacterial and fungal etiology, including Candida albicans.

The introduction of cranberry berries and BAJ of celandine into the toothpaste BAJ provides the complex with an antibiotic effect against anaerobic bacteria, which usually dominate during periodontal disease, parietal suppuration, and complications after tooth extraction.

The introduction of clover oil extract into the toothpaste helps to reduce pain, and together with nettle it acts as a vasoconstrictor and stimulates regeneration, providing anti-inflammatory and keratolytic effects.

The use of eucalyptus oil extract in the composition of the toothpaste stimulates cellular immunity, has an anti-inflammatory, analgesic, antiseptic effect, due to the high antiseptic properties of the plant. Particularly, activity is manifested against pathogenic bacteria, staphylococci, streptococci, and yeast flora.

Due to the introduction of chestnut fruits into the composition of the BAJ, the bleeding of the gums, burning, blood circulation improves, and the risk of thrombosis in the venous capillaries decreases.

The use of celandine oil extract in the composition of the toothpaste improves the clinic of the pathological process; reduces puffiness, cleanses of purulent contents, accelerates the processes of epithelization of eroded surfaces, reducing infiltration in the lesions. A wide range of medicinal properties of celandine associated with alkaloids, essential oils, ascorbic acid, carotene, rutin, histamine, organic acids. Helidonin and homochelidonin determine the analgesic effect, the alkaloid heleritrin, berberine and sanguinarine, concentrating in the chondriosomes of microorganisms, act bactericidal on a number of bacteria and pathogenic fungi by blocking vital enzyme systems. According to the antibiotic effect, celandine is equivalent to chloramphenicol.

The introduction of St. John's wort extract into the toothpaste enhances the antiseptic, anti-inflammatory, astringent properties of toothpaste. St. John's wort has antiseptic, desensitizing effect, stimulates the regeneration of tissues of damaged areas of the gums, has a positive effect on the processes of osteogenesis.

The introduction of lavender essential oil to the composition of the toothpaste supplements the deodorizing effect of St. John's wort, soothes pain, stimulates epithelization and granulation of lesions, and has a pronounced bactericidal effect.

The introduction of sea salt in the composition of the toothpaste increases the ability to dissolve and remove mucus, plaque, food debris, reduces infectious tension, strengthens the gums, prevents the thinning and discoloration of the tooth shawl, demineralization of the teeth.

It should also be noted that natural components are used as the basis of toothpaste, which in combination with phyto base and phytoactive allows you to get a comprehensive safe and hypoallergenic toothpaste that can be used for a long time for prevention and comprehensive treatment with the maximum possible therapeutic and health-improving effect.

Thanks to the use of silicon dioxide and titanium dioxide as an abrasive material, not only delicate mechanical cleaning of the teeth is ensured, which does not damage the enamel surface, but also effective teeth whitening and polishing.

The use of a toothpaste-based regulator and stabilizer of the pH of the medium selected from the group including potassium nitrate and sodium phosphate provides specified pH values of the medium and maintains a constant level of its value. At the same time, the use of potassium nitrate in the basis of toothpaste helps to eliminate tooth sensitivity. The use of such toothpastes by patients with periodontal diseases is especially important when the pathology results in exposure of the necks of the teeth, as well as the formation of wedge-shaped defects.

Sodium phosphate is also an emulsifier and a source of phosphorus for tooth enamel, and additionally provides an effective barrier to plaque formation.

The use of glycerin and sorbitol as a water-retaining component allows to obtain a homogeneous structure of toothpaste, prevent drying and hardening of the paste, which is due to the hygroscopicity of these substances, and at the same time their use is completely harmless to the body and does not cause side effects.

The use of polyvinylpyrrolidone and xanthan gum as a shaping thickener makes it possible to obtain a gel-like paste of a certain density, and at the same time harmless to the body and possessing detoxification properties, due to the ability to complex polyvinylpyrrolidone.

The introduction of xanthan gum provides good gelation and stabilization of the composition of the paste, while its use is completely harmless to the body. The use of sodium saccharin as a sweetener enhances the organoleptic properties of toothpaste.

The use of cocamidopropyl betaine as a cleaning and foaming agent provides a softer and more effective toothbrushing.

Nettle and / or water, or nettle hydrolate, or nettle hydrolate, and nettle hydrolate and water taken in various proportions, depending on need, are used as a toothpaste solvent. At the same time, the use of a nettle-based solvent can further enhance the healing effect of toothpaste. Thus, multifunctional toothpaste provides high-quality hygienic and professional care for teeth and gums without side effects, taking into account a comprehensive individual approach to oral problems.

The invention is as follows.

The main technological vessel is supplied with a solvent - BAJ of nettles and / or water, or nettle hydrolate, or nettle hydrolate and water, taken in various ratios.

Then the stirrer is turned on and sodium phosphate, potassium nitrate, sweetener sodium saccharin, shaping thickeners polyvinylpyrrolidone and xanthan gum, water-retaining components glycerol and sorbitol are added with continuous stirring. Stir until all components are completely dissolved. Then, with moderate stirring, the phyto base, including sage tincture, grapefruit seed extract and the extract of a mixture of medicinal plants such as chamomile, calendula, yarrow, is loaded into the main container and mixed. After that, a cleaning and foaming substance — cocamidopropyl betaine — and abrasive material and bleaching material — silicon dioxide and titanium dioxide — are added to the mixture and mixed until a uniform plastic base of an individual toothpaste is obtained. The resulting toothpaste base is packaged in the required quantity in homogenization bins, which are sealed on top with a membrane.

The preparation of an individual toothpaste is carried out in an apparatus for the manufacture of an individual toothpaste, into which the required number of bins for homogenization and phytoactive dosing elements are loaded: phytoactive A (mixture of BAJ), phytoactive B (water-soluble plant extracts), phytoactive C (a mixture of plant and essential oil extracts oils). According to the established program, depending on the purpose of the individual toothpaste, the necessary amount of the corresponding phytoactive A, B and C is automatically dispensed into the hopper with the base of the toothpaste, where the mixture is homogenized until a homogeneous paste is obtained, then dosed and packaged in a consumer container, which immediately hermetically closes.

Thus, a toothpaste is obtained taking into account a comprehensive individual approach to oral problems.

Example. one.

To prepare an individual toothpaste for hygienic oral care for the prevention of stomatitis, a toothpaste of the following composition is prepared.

Studies have shown that the use of this toothpaste for hygienic oral care for the prevention of stomatitis has an anti-inflammatory, astringent effect, helps restore epithelial integrity in the lamina propria mucosa and submucosa, eliminates edema, stimulates blood circulation in the mucosa, improves protection of the oral mucosa (envelops ), reduces allergization and the risk of ulcerative necrotic processes, inhibits pathogenic microflora (streptococci, staphylococci, f ziformnaya spirillum) and stimulates the activity of the enzyme lysozyme in saliva. Example 2

To prepare an individual toothpaste for professional oral care for stomatitis, a toothpaste of the following composition is prepared.

Studies have shown that the use of this toothpaste for professional oral care for the prevention of stomatitis has an anti-inflammatory, astringent effect, helps restore epithelial integrity in the lamina propria mucosa and submucosa, eliminates edema, stimulates blood circulation in the mucosa, and increases protection of the oral mucosa ( envelops), reduces allergization and the risk of ulcerative necrotic processes, inhibits pathogenic microflora (streptococci, staphylococci , fusiform spirilla), accelerates the process of epithelization in the presence of erosion and ulceration, reduces viral tension and the risk of complications, activates the mechanisms of local immunity of the oral cavity.

Example 3

To prepare an individual toothpaste for hygienic oral care with gingivitis, a toothpaste of the following composition is prepared.

Studies have shown that the use of this toothpaste for hygienic oral care with gingivitis has a pronounced anti-inflammatory effect, limits the process of inflammation and the formation of gingival pockets, protects the gums and mucous membrane from the introduction of pathological flora, reduces bleeding gums and their pain, reduces increased vascular permeability, improves microcirculation in the gingival mucosa and tissues, deodorizes the oral cavity, helps prevent and reduces the risk of gingivitis.

Example 4

To prepare an individual toothpaste for a professional for the oral cavity with gingivitis, a toothpaste of the following composition is prepared.

Studies have shown that the use of this toothpaste for professional oral care for gingivitis and has a pronounced anti-inflammatory effect, limits the process of inflammation and the formation of gingival pockets, protects the gums and mucous membranes from the introduction of pathological flora, reduces bleeding gums and their pain, reduces increased vascular permeability , improves microcirculation in the mucous membrane and gum tissue, deodorizes the oral cavity, weakens the aggression factors of pathological gingival pockets, inhibits the regeneration processes, inhibits the growth of pathological granulation periodontal tissue, strengthens the gums, reduces the risk of complications.

Example 5

To prepare an individual toothpaste for hygienic care of the oral cavity with simple caries, a toothpaste of the following composition is prepared.

Studies have shown that the use of this toothpaste for hygienic oral care in case of simple caries helps to strengthen enamel, reduces the concentration of pathogenic microorganisms and their metabolic products, inhibits rotting, fermentation, and the formation of lactic acid that destroy tooth enamel, effectively cleans plaque, and prevents the formation of dental plaque, has a local anesthetic effect, increases local immunity, the protective properties of saliva and the effectiveness of the prevention of brown sa Example 6

To prepare an individual toothpaste for professional oral care for complicated caries, a toothpaste of the following composition is prepared.

Studies have shown that the use of this toothpaste for professional oral care for complicated caries strengthens the mineral structure of enamel, increases the effectiveness of caries treatment, reduces the concentration of pathogenic microorganisms and their metabolic products, suppresses rotting, fermentation, and the formation of lactic acid that destroy tooth enamel. effectively cleans plaque, prevents tooth decay and tooth enamel sensitivity, improves local immunity and the protective properties of mucus s, prevents the formation of plaque and reduces its calcification, reduces the incidence of complications of periodontitis, periodontosis, providing locally anesthetic effects. The use of toothpaste is effective for caries complicated by periodontitis, for the prevention of pulpitis, periodontopathy, with increased sensitivity of tooth enamel, for cervical caries, as well as for the prevention of complications (periodontitis, periodontal disease).

Example 7

To prepare an individual toothpaste for hygienic oral care with periodontitis, a toothpaste of the following composition is prepared.

Studies have shown that the use of this toothpaste for hygienic oral care during periodontitis has a pronounced antiseptic, anti-inflammatory effect, reduces bacterial contamination, rotting and fermentation in pathological gingival pockets, has a wound healing effect, normalizes proliferation processes, limiting the growth of pathological elements of connective tissue helps restore tooth function, and also improves microcirculation in the gum tissue, increases local immunity of the mucosa, gum tissue and significantly increases the effectiveness of the prevention and treatment of periodontitis. The use of toothpaste is effective in acute periodontitis, serous, purulent periodontitis; as well as with chronic gingivitis complicated by caries and for the prevention of complications of periodontal disease.

Example 8

To prepare an individual toothpaste for professional oral care for chronic periodontitis, a toothpaste of the following composition is prepared.

Studies have shown that the use of this toothpaste for professional oral care in chronic periodontitis has a pronounced antiseptic, anti-inflammatory effect, reduces bacterial contamination, rotting and fermentation in pathological gingival pockets, provides effective wound healing, has an antimicrobial effect, and normalizes proliferation processes, limiting proliferation of pathological elements of connective tissue, helps restore tooth function, uchshaet microcirculation in the tissues of the gums, limiting diffuse spread of exudate outside periodontal reduces autoaggression processes in the lesions, pathological ugnetaeg growth of granulation tissue and the formation of cysts, increases the effectiveness of the prevention of complications, and treatment of periodontitis. The use of toothpaste is effective in cases of complicated caries, chronic periodontitis, serous, purulent periodontitis, fibrous periodontitis, granulomatous and granulating periodontitis, for the treatment of cysts, and prevention of periodontal complications.

Example 9

To prepare an individual toothpaste for hygienic oral care during periodontal disease, a toothpaste of the following composition is prepared.

Studies have shown that the use of this toothpaste for hygienic oral care during periodontal disease reduces infection and inflammation of the gingival wall and soft periodontal tissues, reduces pathological microbial contamination of the oral cavity, effectively cleanses the oral cavity from decay products, plaque, desquamated epithelium, and has an astringent , analgesic, cytostatistical effect, stimulates microcirculation and reparative processes in periodontal tissues, activates the mechanisms of local immunity, reducing there is local autoaggression in the lesions, increases the effectiveness of prevention and treatment of periodontal disease.

The use of toothpaste is effective in the initial stage of periodontal disease, with acute periodontitis, ulcerative necrotic gingivitis, chronic periodontitis, periodontal abscess, bleeding gums with the phenomena of pathological gingival pockets, provides prevention of dystrophic and inflammatory processes in periodontal tissues and the occurrence of bone resorption.

Example 10

To prepare an individual toothpaste for professional oral care for chronic periodontal disease with relapses during exacerbation, a toothpaste of the following composition is prepared.

Lavender Essential Oil 0.01

Nettle leaf BAJ up to 100.00

Studies have shown that the use of this toothpaste for professional oral care in case of chronic periodontal disease with relapses during exacerbation provides a significant reduction in the risk of dystrophic inflammatory processes in the periodontal tissues and alveolar parts of the jaw, reduces pathological microbial contamination of the oral cavity, and limits inflammation of the gingival wall and soft periodontal tissues, reduces local autoaggression in lesions, effectively cleanses the oral cavity from decay products, plaque, desquamated epithelium, has an astringent, analgesic (local anesthetic), cytostatistical effect, stimulates microcirculation and reparative processes in periodontal tissues, reduces the activity of proteolytic enzymes in saliva, the growth of pathological granulations and proliferative processes in the oral mucosa and gums normalizes metabolism periodontal disease, helps to reduce the permeability of histohematological barriers, preventing the occurrence of intracellular and capillary edema, accelerates the process of scarring, and normalizes the cellular composition of the contents of pathological gums, increases the effectiveness of therapeutic interventions.

Thus, the proposed multifunctional toothpaste provides high-quality hygienic and professional care for teeth and gums without side effects, taking into account a comprehensive individual approach to oral problems.

Information sources

1. Patent of the Russian Federation J ° 2462231 C1, publ. 09/27/2012, IPC A61K8 / 98, A61K35 / 60, A61 P1 / 02, A61Q1 1/02.

2. Patent of the Russian Federation Jfe 2262918 C1, publ. 10/27/2005, IPC ⁷ A61K7 / 16, A61P1 / 02.

3. Patent of the Russian Federation jN 2282434 C1, publ. 08/27/2006., IPC A61K8 / 19, A61K8 / 34, A61 K8 / 36, A61K8 / 40, A61K8 / 49, A61Q1 1/00.

27

SUBSTITUTE SHEET (RULE 26)

Claims

CLAIM

1. A multifunctional toothpaste containing a base comprising an abrasive material, a shaping thickener, a water-retaining substance, a cleaning and foaming substance, a sweetener, active substances and a solvent, characterized in that it further comprises a phyto base, and as an active substance contains a phytoactive based on plant components , selected taking into account a comprehensive individual approach to oral problems, with the following ratio of components, in May. %:

Base 50-70

Phyto base 0.1-2.5

Phytoactive 1, 0-3.8

Solvent rest

2. Toothpaste according to claim 1. characterized in that the phyto base is selected from the group comprising sage tincture, grapefruit seed extract and extract of a mixture of medicinal plants such as chamomile, calendula, yarrow.

3. Toothpaste according to claim 1. characterized in that the phytoactive is selected from the group comprising extracts of medicinal plants, essential oils, biologically active liquids (BAJ) from food and medicinal plants, as well as sea salt.

4. Toothpaste according to claim 3. characterized in that the extracts of medicinal plants of the phytoactive are selected from the group comprising aloe vera extract, oil extract of amaranth seeds, oil extract of seeds and root vegetables of carrots, oil extract of rose hips, extract of echinacea, hop cones extract , thyme herb oil extract, juniper berry oil extract, chaga extract, green tea leaf extract, comfrey root extract, Maclea shoot-like extract, sweet clover oil extract, eucalyptus oil extract, l extract stev plantain, oily extract of celandine, herb St. John's wort.

5. Toothpaste p.Z. characterized in that the phytoactive essential oils are selected from the group comprising mint, basil, melissa, oregano, tea tree, nutmeg, fir, lavender.

6. Toothpaste p.Z. characterized in that the biologically active phytoactive fluids are selected from the group of food and medicinal plants, including pine needles, cabbage leaves, rowan fruits, chokeberry fruits, calamus marsh, plantain leaves, elecampane root, rose hips, carrot roots, lemon fruits, root burdock, cranberry and celandine grass.

7. Toothpaste according to claim 1. characterized in that polyvinylpyrrolidone and xanthan gum are selected as the shaping thickener.

8. Toothpaste according to claim 1. characterized in that silicon dioxide and titanium dioxide are selected as abrasive and whitening material.

9. Toothpaste according to claim 1. characterized in that glycerin and sorbitol are selected as a water-retaining substance.

10. Toothpaste according to claim 1. characterized in that cocamidopropyl betaine is selected as a cleaning and foaming substance.

1 1. Toothpaste according to claim 1. characterized in that sodium saccharin is selected as a sweetener.

12. Toothpaste according to claim 1. characterized in that the base contains a pH regulator and stabilizer selected from the group consisting of potassium nitrate and sodium phosphate.

13. Toothpaste according to claim 1. characterized in that the biologically active liquid (BAL) of the nettle leaves and / or water, or nettle hydrolate, or nettle hydrolate and water is selected as a solvent.

29th

SUBSTITUTE SHEET (RULE 26)