WO2014196947A1 - Dentifrice multifonctionnel - Google Patents

Dentifrice multifonctionnel Download PDF

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Publication number
WO2014196947A1
WO2014196947A1 PCT/UA2014/000060 UA2014000060W WO2014196947A1 WO 2014196947 A1 WO2014196947 A1 WO 2014196947A1 UA 2014000060 W UA2014000060 W UA 2014000060W WO 2014196947 A1 WO2014196947 A1 WO 2014196947A1
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WIPO (PCT)
Prior art keywords
toothpaste
extract
phytoactive
base
toothpaste according
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PCT/UA2014/000060
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English (en)
Russian (ru)
Inventor
Валерий Валентинович ПРАВДИН
Владимир Владимирович КАПУСТИН
Original Assignee
Pravdin Valeriy Valentinovch
Kapustin Vladimir Vladimirovich
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Application filed by Pravdin Valeriy Valentinovch, Kapustin Vladimir Vladimirovich filed Critical Pravdin Valeriy Valentinovch
Publication of WO2014196947A1 publication Critical patent/WO2014196947A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/24—Phosphorous; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/29—Titanium; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A61K8/345—Alcohols containing more than one hydroxy group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/37—Esters of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
    • A61K8/442—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof substituted by amido group(s)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
    • A61K8/817—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen; Compositions or derivatives of such polymers, e.g. vinylimidazol, vinylcaprolactame, allylamines (Polyquaternium 6)
    • A61K8/8176—Homopolymers of N-vinyl-pyrrolidones. Compositions of derivatives of such polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
    • A61K8/86—Polyethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9728—Fungi, e.g. yeasts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9755—Gymnosperms [Coniferophyta]
    • A61K8/9761—Cupressaceae [Cypress family], e.g. juniper or cypress
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9789—Magnoliopsida [dicotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9794—Liliopsida [monocotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/48—Thickener, Thickening system

Definitions

  • the invention relates to medicine, namely to dentistry, and can be used as a means for hygiene of teeth and oral cavity and as a therapeutic and prophylactic dental product.
  • a promising direction in the field of production of toothpastes is the development of complex-action toothpaste formulations that not only effectively clean the surface of the teeth, but also have a prophylactic and therapeutic effect on the tissues of the oral cavity and at the same time have a pleasant taste and smell.
  • Known therapeutic toothpaste [1] for the treatment of inflammatory diseases of periodontal and oral mucous membranes containing as active component peptides associated with phospholipids obtained from cod liver, in a quantitative ratio, wt.%: Peptides 40-99 and phospholipids 1-60.
  • the content of peptides in the composition of the toothpaste ranges from 0.01 to May 5.0.
  • % Toothpaste contains until May 65th. % of the base, including abrasive material, a forming thickener, a water-retaining substance, a cleaning and foaming component, a preservative, a dye, perfume, and also a solvent such as purified water at a certain ratio of components.
  • Treatment-and-prophylactic toothpaste may additionally contain an antioxidant, sweetener, and plant extract in the amount of May 0.1-5.0. %, fluorides and / or desensitizing agent.
  • silicon dioxide is used as an abrasive material
  • polyethylene glycol of various molecular weights is used as a shaping thickener
  • sorbitol and glycerin are used as a water-retaining substance
  • sodium lauryl sulfate or sodium laureth sulfate for example, nipagin are used as a preservative
  • colorant and perfume selected from the group of pharmaceutically acceptable and approved for use in the composition of toothpastes dyes, for example, titanium dioxide, and flavoring agents, for example, such as a mint fragrance, and water is used as a solvent.
  • the use of paste improves the condition of periodontal tissues and the oral cavity, relieves inflammatory processes, reduces bleeding, and soreness of the gums.
  • the paste has a healing effect, accelerates reparative processes, improves trophic tissue, does not have a side effect, does not cause allergic reactions and can be used at any age regardless of the presence of concomitant diseases.
  • the main anti-inflammatory component in the known toothpaste are peptides associated with phospholipids obtained from cod liver taken in a certain ratio.
  • the composition of the toothpaste includes a cleaning and foaming component such as sodium lauryl sulfate or sodium laureth sulfate, which are surface-active substances and can cause carcinogens and allergic reactions with prolonged use.
  • a cleaning and foaming component such as sodium lauryl sulfate or sodium laureth sulfate, which are surface-active substances and can cause carcinogens and allergic reactions with prolonged use.
  • Known toothpaste for the prevention of caries containing a base including a foaming agent, an abrasive component, a binder and a colored component, while it contains sodium lauryl sulfate as a foaming agent
  • the abrasive component is chalk, chemically precipitated, or dicalcium phosphate dihydrate or silicon dioxide or titanium dioxide
  • the binder is sodium carboxymethyl cellulose or methyl cellulose
  • the color component is a food coloring or juices, or extracts of berries and vegetables, for example yaemye in the food industry for coloring, while additionally contains humectants as glycerin and / or sorbitol, biological additives, which are saccharin, essential oils of plants or hydroalcoholic extracts of medicinal plants, as well as preservatives and flavoring components at a certain ratio.
  • toothpaste stains areas with microcracks, tartar, beginning caries, which allows you to control the degree of cleaning of the oral cavity at home, diagnose caries in the early stages and detect microcracks and tartar.
  • this toothpaste does not take into account the individual characteristics of the oral cavity and does not provide a sufficient preventive effect.
  • the use of toothpaste with prolonged use can cause the formation of carcinogens, due to the fact that the composition of the toothpaste includes a cleaning and foaming component such as sodium lauryl sulfate or sodium laureth sulfate, which are surfactants.
  • a cleaning and foaming component such as sodium lauryl sulfate or sodium laureth sulfate, which are surfactants.
  • a toothpaste [3] containing a base comprising an abrasive material, a shaping thickener, a water-retaining substance, a cleaning and foaming substance, a sweetener, active substances and a solvent.
  • the paste contains mexido (2-ethyl 6-methyl 3-hydroxypyridine succinate) and calcium citrate in the following ratio, May. %:
  • silicon dioxide is used as an abrasive material
  • carboxymethyl cellulose derivatives are used as a shaping thickener
  • glycerol and / or sorbitol are used as a water-retaining substance
  • sodium lauryl sulfate is used as a cleaning and foaming agent
  • xylitol or saccharin are used as a sweetener
  • xylitol or saccharin are used as a sweetener.
  • substances - Mexidol, and water is used as a solvent.
  • the use of paste leads in a short time to a significant improvement in the condition of periodontal tissues and the oral cavity. Rapid elimination of the inflammatory process, a decrease in edema, bleeding, and soreness of the gums, due to the use of Mexidol, are noted.
  • the paste has a healing effect, accelerates reparative processes, improves trophic tissue.
  • the known toothpaste does not provide the possibility of its long and safe use, which is due to the fact that the toothpaste contains such a cleaning and foaming component as sodium lauryl sulfate, which with prolonged use can cause such a side effect as the formation of carcinogens.
  • a preservative is used in the composition of this paste, such as sodium benzoate, methyl paraben or other similar chemical components that increase the shelf life of the toothpaste, but can cause allergic reactions.
  • Mexidol can also cause allergic reactions.
  • the basis of the invention is the task of creating such a multifunctional toothpaste, in which by using natural components taken in a certain ratio and taking into account a comprehensive individual approach to oral problems, high-quality hygienic and professional care of teeth and gums is achieved without side effects.
  • the problem is solved in that in a known toothpaste containing a base comprising an abrasive material, a shaping thickener, a water-retaining substance, a cleaning and foaming substance, a sweetener, active substances and a solvent, according to the invention, additionally contains phyto base, the active substance contains phytoactive based on plant components, selected taking into account a comprehensive individual approach to oral problems, with the following ratio of components, in May. %:
  • the phyto base is selected from the group including sage tincture, grapefruit seed extract and extract of a mixture of medicinal plants such as chamomile, calendula, yarrow.
  • the phytoactive is selected from the group including extracts of medicinal plants, essential oils, biologically active liquids from food and medicinal plants, as well as sea salt.
  • herbal extracts of the phytoactive plant are selected from the group consisting of aloe vera extract, oil extract of amaranth seeds, oil extract of seeds and root vegetables of carrots, oil extract of rose hips, extract of echinacea, extract of hop cones, oil extract of thyme grass, oil extract of juniper berries, chaga extract, green tea leaf extract, comfrey root extract, hearty macklea shoot extract, clover oil extract, eucalyptus oil extract, plantain leaf extract, oil extract celandine tract, St. John's wort herb extract.
  • phytoactive essential oils are selected from the group including mint, basil, lemon balm, oregano, tea tree, nutmeg, fir, lavender.
  • biologically active phytoactive fluids are selected from the group consisting of pine needles, cabbage leaves, common mountain ash fruits, chokeberry fruits, calamus marsh, plantain leaves, elecampane root, rose hips, carrot root vegetables, lemon fruits, burdock root, cranberry berries and celandine grass.
  • polyvinylpyrrolidone and xanthan gum are selected as the shaping thickener.
  • silicon dioxide and titanium dioxide were selected as abrasive and bleaching material.
  • glycerin and sorbitol were selected as a water-retaining substance.
  • Cocamidopropyl betaine was selected as a cleaning and foaming agent.
  • the base contains a pH regulator and stabilizer selected from the group consisting of potassium nitrate and sodium phosphate.
  • a biologically active liquid of nettle leaves and / or water, or nettle hydrolate, or nettle hydrolate and water was chosen as a solvent.
  • the rate of plaque formation and its localization, in the absence of oral hygiene, depends on the individual characteristics of a person, diet, saliva secretion and its composition.
  • the effectiveness of treatment programs in dentistry depends on the selection of toothpaste.
  • the quality of the toothpaste depends on the formulation of the constituent ingredients of the toothpaste, the effect on all links of pathogenesis. Toothpastes carry out not only a professional approach to hygiene, but also activate the therapeutic effect against possible diseases of the oral cavity - caries and inflammatory diseases: periodontitis, gingivitis, stomatitis.
  • a distinctive feature of the proposed multifunctional toothpaste is its full natural origin, i.e. phyto base and phytoactive toothpastes consists of the most effective medicinal plants used in dental practice.
  • BAJ intercellular and intracellular fluid
  • the phyto base of toothpaste is selected from the group including sage tincture, grapefruit seed extract and extract of a mixture of medicinal plants, such as chamomile, calendula, yarrow.
  • Sage tincture - refers to a strong disinfectant herbal medicines that can destroy pathogens of infectious diseases.
  • the pharmacological effect of sage is determined by the tannins and essential oils contained in it. They favorably affect the microflora of pathological gingival pockets, suppressing and inhibiting the growth and reproduction of pathological microflora (antiseptic properties); inhibit the inflammatory process in various phases of its development, contribute to the development of epithelial tissue covering the oral mucosa; prevent the process of protein breakdown when exposed to putrefactive microorganisms (anti-putrefactive effect); protect the mucosa (astringent action); inhibit the development and vital activity of viruses (antiviral effect).
  • Grapefruit seed extract is a broad-spectrum antiseptic, antifungal, antibacterial natural extract of bioflavonoids, vitamin C, glycosides and protein. It is most effective against museum and clinical strains of Candida fungi. It is superior to Diflucan, Candide, Dekasan in antifungal activity. Thanks to the use of grapefruit seed extract, toothpaste has an antibacterial effect, based on damage to the cytoplasmic membrane, cell wall and inhibiting the synthesis of bacterial amino acids. The extract has antibacterial activity against staphylococci, streptococci and other pathogens, including anaerobic bacteria, which dominate in infections of the oral cavity (gingivitis, ulcers of the mucous membrane, paradental suppuration, with complications after tooth extraction).
  • P-vitamin activity is determined, which eliminates and prevents the increased fragility of capillaries and the permeability of the vascular wall during inflammatory processes, maintaining the structure, elasticity and strength of blood vessels.
  • the extract has a pronounced antioxidant effect.
  • Extracts of chamomile, calendula, yarrow have pronounced properties to reduce microbial contamination of the oral cavity and the possibility of microorganisms entering the bloodstream; clean the mucous membrane of the products of decay, plaque, mucus, desquamated epithelium; improve the outflow of metabolic products from tissues; stop the clinical manifestations of diseases (pain, bleeding gums, inflammation); normalize trophic mucosa; activate the mechanisms of local immunity of the oral cavity; help strengthen capillaries; reduce leukocyte migration on the surface of the mucosa.
  • the most important composition in multifunctional toothpastes belongs to the phytoactive. Thanks to the phytoactive agent, which consists of extracts of medicinal plants, essential oils, biologically active liquid from food and medicinal plants, the therapeutic effect is ensured when the diagnosis is made.
  • the composition of the phytoactive is chosen taking into account a comprehensive individual approach to problems of the oral cavity.
  • the action of medicinal and food plants included in the phytoactive is designed for high permeability of the oral mucosa for various substances. It has been established that some vitamins, phosphates, calcium, potassium and other biologically active substances penetrate relatively quickly through the mucous membranes of the mouth, tongue, gums and have a beneficial effect on periodontal tissues. In this regard, the use for preventive and therapeutic purposes of special toothpastes, which include vitamins, chlorophyll, micro and macro elements, biologically active substances, is very advisable.
  • Toothpaste phytoactive is selected from the group including extracts of medicinal plants, essential oils, biologically active liquids (BAL) from food and medicinal plants, as well as sea salt.
  • Herbal extracts of the phytoactive plant are selected from the group consisting of aloe vera extract, oil extract of amaranth seeds, oil extract of seeds and root vegetables of carrots, oil extract of rose hips, extract of echinacea, extract of hop cones, oil extract of thyme grass, oil extract of juniper berries, oil extract of juniper berries, , green tea leaf extract, comfrey root extract, Maclea shoots heart-shaped, clover oil extract, eucalyptus oil extract, plantain leaf extract, pure oil extract He ate grass St. John's wort.
  • basil essential oil increases the activity of lysozyme in saliva, enhancing the antibacterial effect of toothpaste, which leads to inhibition of pathogenic microflora
  • peppermint essential oil stimulates wound healing. At the same time, peppermint essential oil has a wound healing, anti-inflammatory and deodorizing property.
  • the BAJ of the leaves of plantain provides an anti-inflammatory effect of the paste.
  • Long-term chronic inflammation is usually accompanied by a significant decrease in the content of vitamins C and P in the oral mucosa, which is eliminated due to the use of aronia fruits, rosehip oil extract, seed oil extract, and carrot root in the toothpaste BAJ.
  • Rosehip oil extract helps to eliminate lymphoid-plasmacytic infiltrates (desensitizing effect), normalizes the metabolism of nucleoproteins, and resists atrophic changes in the mucosa.
  • the extracts of herbs of antimicrobial, anti-inflammatory, enveloping, keratoplastic, wound healing, anti-ulcer nature are important, for which purpose plantain leaves leaf oil, rosehip oil extract, and rosehip oil, tincture, tincture, and tincture are also added. Seed and root extract of carrots.
  • lemon balm essential oil is introduced into the composition of the toothpaste.
  • hop cones extract To eliminate inflammation and eliminate pathological gingival pockets, improve microcirculation in the mucous membranes and gum tissues in the composition of the paste, a combination of BAJs of chestnut fruits and hop cones extract are used. At the same time, the extract of hop cones has an additional analgesic effect (local anesthetic), reduces local autoaggression in the lesion foci.
  • echinacea extract in the toothpaste enhances local immunity and the protective properties of the mucosa, has an anti-inflammatory, antimicrobial, wound healing effect with an antioxidant effect.
  • Oil extracts of juniper and thyme herbs have selective antibacterial activity against antibiotic-resistant strains of staphylococcus, reduce swelling of inflamed tissues, and resist pathogenic fungal flora.
  • the use of essential oil of oregano in the composition of the toothpaste provides antibacterial properties of the toothpaste, eliminates unpleasant odor (deodorizing effect). Due to the fact that the extract of chaga (birch fungus) contains anthocyanidins that form colloidal aqueous solutions, agaricic acid, triterlinoid, inotodiol, resins, the cytostatic effect of toothpaste is provided for hypertrophic gum growths. The introduction of tea tree essential oil into the toothpaste provides an additional anti-inflammatory, wound healing effect.
  • green tea extract in the toothpaste, which is a natural source of fluorine and tannins, carbohydrate metabolism is restrained and suppressed, acid aggression in the oral cavity is reduced, which helps strengthen the hard tissues of the tooth and, to a certain extent, reduces the risk of tooth decay.
  • nutmeg essential oil in combination with other anti-caries ingredients in the toothpaste helps to significantly reduce the indicators that cause tooth damage, primarily reducing the risk of tooth decay.
  • fir essential oil into the toothpaste, the antimicrobial and wound healing effect is enhanced, microcirculation is improved, the regeneration of wound surfaces is accelerated, due to the fact that the chemical composition of fir includes borne acetate, borneol, camphene, etc.
  • burdock root which is a natural active antibiotic, into the toothpaste BAJ inhibits the growth of gram-positive microorganisms, corrects water-salt metabolism, accelerates the healing of ulcerative defects, stimulates the restoration of connective tissue, limits inflammation in the mouth and gums.
  • composition of toothpaste of the extract of makleia heart-shaped which is a natural antibiotic
  • Maclayia as an alternative to antibiotics, is especially relevant for infectious and inflammatory diseases of the mucous membrane and gum tissues of bacterial and fungal etiology, including Candida albicans.
  • clover oil extract helps to reduce pain, and together with nettle it acts as a vasoconstrictor and stimulates regeneration, providing anti-inflammatory and keratolytic effects.
  • eucalyptus oil extract in the composition of the toothpaste stimulates cellular immunity, has an anti-inflammatory, analgesic, antiseptic effect, due to the high antiseptic properties of the plant. Particularly, activity is manifested against pathogenic bacteria, staphylococci, streptococci, and yeast flora.
  • celandine oil extract in the composition of the toothpaste improves the clinic of the pathological process; reduces puffiness, cleanses of purulent contents, accelerates the processes of epithelization of eroded surfaces, reducing infiltration in the lesions.
  • Helidonin and homochelidonin determine the analgesic effect, the alkaloid heleritrin, berberine and sanguinarine, concentrating in the chondriosomes of microorganisms, act bactericidal on a number of bacteria and pathogenic fungi by blocking vital enzyme systems. According to the antibiotic effect, celandine is equivalent to chloramphenicol.
  • St. John's wort extract into the toothpaste enhances the antiseptic, anti-inflammatory, astringent properties of toothpaste.
  • St. John's wort has antiseptic, desensitizing effect, stimulates the regeneration of tissues of damaged areas of the gums, has a positive effect on the processes of osteogenesis.
  • lavender essential oil to the composition of the toothpaste supplements the deodorizing effect of St. John's wort, soothes pain, stimulates epithelization and granulation of lesions, and has a pronounced bactericidal effect.
  • sea salt in the composition of the toothpaste increases the ability to dissolve and remove mucus, plaque, food debris, reduces infectious tension, strengthens the gums, prevents the thinning and discoloration of the tooth shawl, demineralization of the teeth.
  • a toothpaste-based regulator and stabilizer of the pH of the medium selected from the group including potassium nitrate and sodium phosphate provides specified pH values of the medium and maintains a constant level of its value.
  • the use of potassium nitrate in the basis of toothpaste helps to eliminate tooth sensitivity.
  • the use of such toothpastes by patients with periodontal diseases is especially important when the pathology results in exposure of the necks of the teeth, as well as the formation of wedge-shaped defects.
  • Sodium phosphate is also an emulsifier and a source of phosphorus for tooth enamel, and additionally provides an effective barrier to plaque formation.
  • glycerin and sorbitol as a water-retaining component allows to obtain a homogeneous structure of toothpaste, prevent drying and hardening of the paste, which is due to the hygroscopicity of these substances, and at the same time their use is completely harmless to the body and does not cause side effects.
  • polyvinylpyrrolidone and xanthan gum as a shaping thickener makes it possible to obtain a gel-like paste of a certain density, and at the same time harmless to the body and possessing detoxification properties, due to the ability to complex polyvinylpyrrolidone.
  • xanthan gum provides good gelation and stabilization of the composition of the paste, while its use is completely harmless to the body.
  • sodium saccharin as a sweetener enhances the organoleptic properties of toothpaste.
  • cocamidopropyl betaine as a cleaning and foaming agent provides a softer and more effective toothbrushing.
  • Nettle and / or water, or nettle hydrolate, or nettle hydrolate, and nettle hydrolate and water taken in various proportions, depending on need, are used as a toothpaste solvent.
  • the use of a nettle-based solvent can further enhance the healing effect of toothpaste.
  • multifunctional toothpaste provides high-quality hygienic and professional care for teeth and gums without side effects, taking into account a comprehensive individual approach to oral problems.
  • the invention is as follows.
  • the main technological vessel is supplied with a solvent - BAJ of nettles and / or water, or nettle hydrolate, or nettle hydrolate and water, taken in various ratios.
  • stirrer is turned on and sodium phosphate, potassium nitrate, sweetener sodium saccharin, shaping thickeners polyvinylpyrrolidone and xanthan gum, water-retaining components glycerol and sorbitol are added with continuous stirring. Stir until all components are completely dissolved. Then, with moderate stirring, the phyto base, including sage tincture, grapefruit seed extract and the extract of a mixture of medicinal plants such as chamomile, calendula, yarrow, is loaded into the main container and mixed.
  • a cleaning and foaming substance cocamidopropyl betaine — and abrasive material and bleaching material — silicon dioxide and titanium dioxide — are added to the mixture and mixed until a uniform plastic base of an individual toothpaste is obtained.
  • the resulting toothpaste base is packaged in the required quantity in homogenization bins, which are sealed on top with a membrane.
  • the preparation of an individual toothpaste is carried out in an apparatus for the manufacture of an individual toothpaste, into which the required number of bins for homogenization and phytoactive dosing elements are loaded: phytoactive A (mixture of BAJ), phytoactive B (water-soluble plant extracts), phytoactive C (a mixture of plant and essential oil extracts oils).
  • phytoactive A mixture of BAJ
  • phytoactive B water-soluble plant extracts
  • phytoactive C a mixture of plant and essential oil extracts oils
  • a toothpaste of the following composition is prepared.
  • a toothpaste of the following composition is prepared.
  • a toothpaste of the following composition is prepared.
  • a toothpaste of the following composition is prepared.
  • a toothpaste of the following composition is prepared.
  • a toothpaste of the following composition is prepared.
  • a toothpaste of the following composition is prepared.
  • a toothpaste of the following composition is prepared.
  • toothpaste is effective in cases of complicated caries, chronic periodontitis, serous, purulent periodontitis, fibrous periodontitis, granulomatous and granulating periodontitis, for the treatment of cysts, and prevention of periodontal complications.
  • a toothpaste of the following composition is prepared.
  • toothpaste is effective in the initial stage of periodontal disease, with acute periodontitis, ulcerative necrotic gingivitis, chronic periodontitis, periodontal abscess, bleeding gums with the phenomena of pathological gingival pockets, provides prevention of dystrophic and inflammatory processes in periodontal tissues and the occurrence of bone resorption.
  • a toothpaste of the following composition is prepared.
  • the proposed multifunctional toothpaste provides high-quality hygienic and professional care for teeth and gums without side effects, taking into account a comprehensive individual approach to oral problems.

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Botany (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Chemical & Material Sciences (AREA)
  • Emergency Medicine (AREA)
  • Inorganic Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Cosmetics (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

L'invention se rapporte au domaine de la médecine et notamment de la stomatologie, et peut être utilisée comme agent pour l'hygiène dentaire et la cavité buccale ainsi que comme agent thérapeutique-prophylactique en stomatologie. Ce dentifrice multifonctionnel comprend une base comprenant un matériau abrasif, un épaississant de mise en forme, une substance de maintien d'humidité, une substance nettoyante et générant de la mousse, un édulcorant, des substances actives et un solvant, et comprend également une base phyto, les substances actives consistant en un phyto-actif à base de composants végétaux choisis en tenant compte d'une démarche individuelle complexe concernant les problèmes de cavité buccale, ceci selon les proportions suivantes des composants en % en poids : Base 50-70 ; base phyto 0,1-2,5 ; phyto-actif 1,0-3,8 ; le reste se composant de solvant. Ce dentifrice multifonctionnel assure un entretien hygiénique et professionnel de qualité pour les dents et les gencives sans effets indésirables sur la base d'une démarche individuelle complexe concernant les problèmes de la cavité buccale.
PCT/UA2014/000060 2013-06-07 2014-06-10 Dentifrice multifonctionnel WO2014196947A1 (fr)

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UA201307259 2013-06-07

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RU2598740C1 (ru) * 2015-07-30 2016-09-27 Общество с ограниченной ответственностью "Научно-производственный центр "Джи-Фарм" Лечебно-профилактический ополаскиватель для десен
WO2020027689A1 (fr) * 2018-08-01 2020-02-06 Общество С Ограниченной Ответственностью "Сплат Глобал" Nouvelles utilisations d'une combinaison d'extrait de baies de genièvre et de charbon
CN111434329A (zh) * 2019-01-11 2020-07-21 薪火炙药(北京)科技有限公司 一种含花椒提取物的抑菌抗炎保健牙膏
CN112791029A (zh) * 2021-03-12 2021-05-14 云南根之然生物科技有限公司 含有工业大麻根微胶囊和植物提取物的组合物及其应用
EP3737351A4 (fr) * 2017-08-31 2021-11-24 MGE Holdings LLC Compositions et méthodes d'hygiène buccale
CN114533611A (zh) * 2022-02-16 2022-05-27 重庆登康口腔护理用品股份有限公司 一种可增强生物活性材料抗牙本质敏感效果的组合物及其制备方法与应用
CN114795997A (zh) * 2022-05-30 2022-07-29 有货(北京)信息技术有限公司 一种含有nmn的氨基酸牙膏及其制备方法
RU2779546C2 (ru) * 2020-03-11 2022-09-08 Федеральное государственное бюджетное образовательное учреждение высшего образования "Северо-Осетинский государственный университет имени Коста Левановича Хетагурова" (ФГБОУ ВО СОГУ им. К.Л. Хетагурова) Многофункциональная индивидуальная зубная паста

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RU2598740C1 (ru) * 2015-07-30 2016-09-27 Общество с ограниченной ответственностью "Научно-производственный центр "Джи-Фарм" Лечебно-профилактический ополаскиватель для десен
EP3737351A4 (fr) * 2017-08-31 2021-11-24 MGE Holdings LLC Compositions et méthodes d'hygiène buccale
WO2020027689A1 (fr) * 2018-08-01 2020-02-06 Общество С Ограниченной Ответственностью "Сплат Глобал" Nouvelles utilisations d'une combinaison d'extrait de baies de genièvre et de charbon
CN111434329A (zh) * 2019-01-11 2020-07-21 薪火炙药(北京)科技有限公司 一种含花椒提取物的抑菌抗炎保健牙膏
RU2779546C2 (ru) * 2020-03-11 2022-09-08 Федеральное государственное бюджетное образовательное учреждение высшего образования "Северо-Осетинский государственный университет имени Коста Левановича Хетагурова" (ФГБОУ ВО СОГУ им. К.Л. Хетагурова) Многофункциональная индивидуальная зубная паста
CN112791029A (zh) * 2021-03-12 2021-05-14 云南根之然生物科技有限公司 含有工业大麻根微胶囊和植物提取物的组合物及其应用
CN114533611A (zh) * 2022-02-16 2022-05-27 重庆登康口腔护理用品股份有限公司 一种可增强生物活性材料抗牙本质敏感效果的组合物及其制备方法与应用
CN114533611B (zh) * 2022-02-16 2023-08-29 重庆登康口腔护理用品股份有限公司 一种可增强生物活性材料抗牙本质敏感效果的组合物及其制备方法与应用
CN114795997A (zh) * 2022-05-30 2022-07-29 有货(北京)信息技术有限公司 一种含有nmn的氨基酸牙膏及其制备方法
CN114795997B (zh) * 2022-05-30 2023-08-01 有货(北京)信息技术有限公司 一种含有nmn的氨基酸牙膏及其制备方法

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