WO2020095099A1 - Composition cosmétique pour le soin de la cavite buccale - Google Patents

Composition cosmétique pour le soin de la cavite buccale Download PDF

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Publication number
WO2020095099A1
WO2020095099A1 PCT/IB2018/059200 IB2018059200W WO2020095099A1 WO 2020095099 A1 WO2020095099 A1 WO 2020095099A1 IB 2018059200 W IB2018059200 W IB 2018059200W WO 2020095099 A1 WO2020095099 A1 WO 2020095099A1
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Prior art keywords
sodium
extract
chloride
calcium
complex
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PCT/IB2018/059200
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English (en)
Russian (ru)
Inventor
Илья ГЕРЧИКОВ
Ольга ЛАНДО
Рита ПЛЯВНИЕЦЕ
Original Assignee
Акцию Сабиедриба "Дзинтарс"
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Priority claimed from LVP-18-85 external-priority patent/LV15495B/lv
Application filed by Акцию Сабиедриба "Дзинтарс" filed Critical Акцию Сабиедриба "Дзинтарс"
Publication of WO2020095099A1 publication Critical patent/WO2020095099A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/20—Halogens; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/20—Halogens; Compounds thereof
    • A61K8/21—Fluorides; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
    • A61K8/368—Carboxylic acids; Salts or anhydrides thereof with carboxyl groups directly bound to carbon atoms of aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/55—Phosphorus compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9789—Magnoliopsida [dicotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9794—Liliopsida [monocotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses

Definitions

  • the invention relates to medicine, namely to dentistry, to means for the care of teeth and oral cavity.
  • Remodent powder consists of trace elements of calcium, magnesium, potassium, sodium, chlorine and is available in the form of a white amorphous powder, from which 2.5-3% solutions are prepared.
  • the specified powder is used in the form of applications and introduced into the hard tissues of the tooth using electrophoresis. After electrophoresis or application, cotton swabs moistened with 1-2% sodium fluoride solution are applied to the treated teeth for 2-3 minutes.
  • compositions for the prevention and treatment of diseases of the oral cavity and the care of teeth and oral cavity are also known.
  • This composition is an aqueous extract of herbs of chamomile pharmacy, Hypericum perforatum, dried marshmallow, Echinacea purpurea, medicinal sage leaves, common oak bark, and calamus swamp.
  • the disadvantage of this tool is the low antibacterial and anti-inflammatory effect.
  • the patent of the Russian Federation N ° 2 355 380 (13) Cl, “Dental Elixir”, MKI A61K 8/18, A61K 8/97 (declared. 11.01.2008).
  • the specified tool is used for the prevention and treatment of initial forms of dental caries and contains glycerin, ethyl alcohol, sodium fluoride, calcium hydroxyapatite, desorbent pectin, plant extracts of leaves of coltsfoot, and laurel noble, essential oils of peppermint, ball eucalyptus and water taken in a specific ratio.
  • the above-described dental elixir prevents the formation of plaque and plaque, has remineralizing, anti-carious, cleansing and deodorizing effects. However, it is not effective enough in the case of remineralization and restoration of tooth enamel, as it contains an insufficient amount of the ingredients intended for this (salts of potassium and magnesium ions, extracts of medicinal plants).
  • the closest in technical essence is “Gel for remineralization of tooth enamel”, (RF patent, N ° RU2403007, application form 10.22.2009, MKI A61K6 / 00), which contains a remineralizing complex in the form of calcium, magnesium, sodium and potassium salts, structure-forming base, and water.
  • the structure-forming - gel-forming base is formed by the sodium salt of carboxymethyl cellulose, its remineralizing composition includes calcium chloride, magnesium chloride or magnesium sulfate, sodium chloride, sodium dihydrogen phosphate, potassium hydrogen phosphate, potassium dihydrogen phosphate and, in addition, urea is introduced into the gel composition, the gel ensures its physiology high mineralizing properties, allows you to use the gel to treat children.
  • the aim of the invention is the creation of a highly effective means for caring for the oral cavity in the form of various products - a tooth elixir (mouth rinse), toothpaste or gel-like toothpaste, intended for a wide range of users, providing antimicrobial action that inhibits the growth of bacteria responsible for the occurrence caries and inflammatory processes in the oral cavity, enhanced remineralizing effect and reducing inflammation and bleeding of the gums, improving the condition of the gums with p riodontite.
  • the inventive cosmetic product for caring for the oral cavity containing a remineralizing complex in the form of salts of calcium, magnesium, sodium and potassium, a structure-forming base, and water, additionally contains an antimicrobial complex, plant extracts, menthol and preservative.
  • a remineralizing complex it contains a complex of calcium, magnesium, potassium and sodium ions contained in sodium fluoride and / or calcium chloride, calcium glycerophosphate, magnesium chloride, potassium chloride, sodium chloride and EDTA disodium salt.
  • the product contains methyl salicylate, anethole, essential oils of eucalyptus, peppermint, sweet orange, clove essential oil and / or clove extract.
  • the claimed agent contains sorbitol and / or sodium carboxymethyl cellulose and / or hydrated silicon dioxide and / or polyvinylpyrrolidone.
  • sodium lauryl sulfate and / or polysorbate 80 colorants and flavoring are additionally introduced into the claimed product.
  • the inventive cosmetic product contains these components in the following proportions, wt%
  • Methyl salicylate 0.05-0.25
  • Peppermint essential oil 0.01-1.5
  • Extract of sage and / or aloe leaves 1.0-5.0 Extract of oak bark 0.5-2.O Extract of calamus rhizome 0.5-2.O Extract of chamomile flowers 0.5-2.0 Extract of rowan fruit 0.5-2.0 Extract of bearberry leaves 0.1-2. O Sea buckthorn fruit extract 0.1-2. ⁇ Sodium saccharinate 0.01-0.25 Disodium salt of EDTA 0.1-0.2 Calcium chloride 0.1-1.0 Magnesium chloride 0.05-1.0
  • Preservative ethyl alcohol and / or sodium
  • the inventive tool contains a special complex consisting of methyl salicylate, anethole, essential oils of eucalyptus, peppermint, sweet orange, clove essential oil and / or clove extract, which has antimicrobial properties and inhibits the growth of Streptococcus mutans and Lactobacillus acidophilus, responsible for the occurrence of caries and inflammatory caries the oral cavity.
  • Remodent animal powder, obtained earlier from the bones of young cattle, containing ions of calcium, magnesium, potassium, sodium, phosphorus, chlorine, as well as manganese, iron, zinc, copper and trace elements.
  • a complex of mineral salts of non-animal origin calcium chloride, magnesium chloride, potassium chloride, sodium chloride, calcium glycerophosphate
  • extracts of medicinal plants containing manganese, iron, zinc, copper and trace elements were used.
  • the remineralizing complex can be supplemented with sodium fluoride, which helps to reduce tiny damage to the tooth enamel and make the teeth more resistant to destruction.
  • a specially selected composition of plant extracts of aloe leaves, oak bark, rowan and sea buckthorn fruits, calamus rhizomes, chamomile flowers and bearberry leaves reduces inflammation and bleeding of the gums, strengthens them and disinfects the oral cavity, improving the condition of the gums during periodontitis.
  • the product may also contain sage.
  • toothpaste or gel-like toothpaste - a cosmetic product may contain various colorants, a flavoring agent and a structure-forming base.
  • Menthol gives mint freshness, stimulates the cold receptors of the mucous membranes, a weak antiseptic, has a mild antibacterial effect. Introduced in the amount of 0.05 - 0.2%
  • Eucalyptus essential oil (Eucalyptus Globulus Leaf Oil) has anti-inflammatory, wound healing, local anesthetic, as well as astringent and tonic properties. It has microbiological activity against gram-positive, gram-negative microorganisms, has a detrimental effect on fungi and protozoa, which is due to the bactericidal effect. Introduced in the amount of 0.1 - 0.5%
  • Methyl Salicylate is a methyl ester of salicylic acid. Used as an antiseptic, anti-inflammatory and analgesic. Introduced in the amount of 0.05 - 0.25%
  • Anethol (Anethol) - a component of the essential oils of anise, fennel, star anise, etc. It is used as an antiseptic and flavor. Introduced in the amount of 0.01 - 0.05%
  • Sweet Orange Essential Oil (Citrus Aurantium Dulcis (Orange) Peel Oil) - soothes, refreshes, tones. How is an antiseptic used for oral ulcers. It has anti-inflammatory effect. Introduced in the amount of 0.01 - 0.25%
  • Peppermint essential oil (Mentha Arvensis Herb Oil and / or Mentha Viridis Leaf Oil and / or Mentha Spicata Herb Oil) - has a tonic, refreshing, deodorizing, antiseptic and analgesic effect. Widely used in toothpastes. It is rich in compounds with high antibacterial activity, indicated for use in the treatment of wounds. Introduced in the amount of 0.01 - 1.5%
  • Clove essential oil (Eugenia Caryophyllus Leaf Oil) and / or clove extract (Eugenia Caryophyllus Bud Extract) have anti-inflammatory effects and are used as a bactericidal and fungicidal component in toothpaste formulations. Introduced in the amount of 0.01 - 0.5%
  • abrasive polishing components of silicon, calcium glycerophosphate and a special antimicrobial complex consisting of methyl salicylate, anethole, essential oils of eucalyptus, peppermint, sweet orange, cloves and / or clove extract not only effectively removes plaque, but also prevents the formation of bacterial plaque, and polishes enamel, returning natural whiteness to teeth.
  • Sage leaf extract (Salvia Officinalis Leaf Extract) has an astringent, antibacterial, antiseptic, anti-inflammatory effect. Introduced in the amount of 1.0 - 5.0%
  • Aloe leaf extract (Aloe Barbadensis Leaf Extract) has a pronounced moisturizing, anti-inflammatory, regenerating, bacteriostatic effect. It enhances the regeneration processes and increases the body's defenses. As a stimulant of adaptive and protective reactions, it is widely used to enhance regenerative processes in injuries and slowly healing wounds. It is used to treat long-term non-healing wounds and ulcers, with inflammatory diseases of the oral cavity. Introduced in the amount of 1.0 - 5.0%
  • Oak bark extract (Quercus Robus Bark Extract) has astringent and antiseptic properties. Used as part of preventive toothpastes against bleeding gums. Effective as an anti-inflammatory agent for diseases of the oral cavity, it is used as a blood vessel strengthening agent. Introduced in the amount of 0.5-2.0%
  • Calamus Root Extract (Acorus Calamus Root Extract) has a tonic, anti-inflammatory, fungicidal effect. It is used for bleeding gums, with inflammation of the mucous membrane of the oral cavity and gums. Introduced in the amount of 0.5-2.0%
  • Chamomilla Recutita Flower Extract has bactericidal, anti-inflammatory, sedative, analgesic and wound healing properties. It is used for inflammatory diseases of the oral cavity and for fungal inflammations of the oral mucosa. Introduced in the amount of 0.5 - 2.0%
  • Rowan fruit extract (Sorbus Aucuparia Fruit Extract) has a bactericidal effect and is used in the treatment of wounds. It has a positive effect in periodontal diseases. Introduced in the amount of 0.5-2.0%
  • Bearberry leaf extract (Arctostaphylos Uva Ursi Leaf Extract) has an antiseptic and anti-inflammatory effect. Included in the treatment of periodontitis. Introduced in the amount of 0.1-2.0%
  • Sea buckthorn fruit extract (Hippophae Rhamnoides Fruit Extract) has an epithelizing and anesthetic effect. It has antibacterial properties, has high biological activity, helps to accelerate epithelization and has a stimulating effect on wound healing. Helps with lesions of the oral mucosa. Introduced in the amount of 0.1-2.0%
  • the complex of plant extracts has bactericidal, antiseptic, anti-inflammatory, sedative, analgesic and wound healing properties, and also contains manganese, iron, zinc and trace elements necessary for remineralization of dental tissue.
  • Ethyl alcohol and / or sodium benzoate were introduced into the agent as a preservative in an amount of 0.1–20.0%.
  • Ethyl alcohol (Alcohol) - wine alcohol, ethanol, is widely used in cosmetics and perfumes as a solvent, preserving, disinfecting and drying additive.
  • a flavoring supplement such as sodium saccharin (Sodium Saccharin)
  • sodium saccharin sodium Saccharin
  • Cosmetics it is used to sweeten toothpastes, elixirs.
  • Disodium EDTA Disodium EDTA
  • EDTA disodium salt of ethylenediaminetetraacetate, complexing agent. It forms strong complexes with metal cations, prevents precipitation and retains metal salts, primarily magnesium and calcium, in dissolved bio-digestible form. Introduced in the amount of 0.1 - 0.2%
  • Calcium Chloride (Calcium Chloride) compensates for the deficiency of calcium ions. It has anti-inflammatory effect. It is a natural component of saliva. Participates in the remineralization and restoration of tooth enamel. Introduced in the amount of 0.1-1.0%
  • Magnesium Chloride (Magnesium Chloride) has an anti-inflammatory and astringent effect. It activates alkaline phosphatase, provides a mineralizing function of saliva. In addition, magnesium chloride directly affects biomineralization by changing the size and orientation of enamel hydroxyapatite crystals. Introduced in the amount of 0.05-1.0%
  • Sodium fluoride (Sodium Fluoride) is used in toothpastes as an active additive for the prevention of caries, as well as a disinfectant and preservative component. Fluoride prevents the development of caries, helping to strengthen tooth enamel.
  • Potassium Chloride reduces the sensitivity of tooth tissue. Potassium ions are deposited on the surface of the nerve fiber, block the nerve impulse, so that the feeling of pain disappears. It is used in dental products for people with hypersensitivity of teeth.
  • Sodium Chloride (Sodium Chloride) - is a natural component of saliva. Introduced in the amount of 0.1- 0.9%
  • Calcium glycerophosphate (Calcium Glycerophosphate) has a remineralizing effect. Strengthens tooth enamel, providing caries prevention. Introduced in the amount of 0.1-1.0%
  • CI 42090, CI 19140 and CI 77891 were introduced into the composition, in an amount of 0.001- 1.15%
  • Dye (CI 42090), is a synthetic aniline blue dye used to color cosmetics. It has strong antiseptic properties. Registered as food supplement E 133.
  • Dye (CI 19140) - yellow dye, a product of the processing of coal. It is applied in the food and cosmetic industry. Registered as food supplement E 162.
  • Dye (CI 77891) titanium dioxide, white inorganic pigment.
  • highly purified and finely dispersed titanium dioxide is used, which has a high hiding power, coloring and opalescent effect.
  • Sorbitol Sorbitol
  • Sodium carboxymethyl cellulose Cellulose Gum
  • Hydrated Silica Hydroated Silica
  • PVP Polyvinylpyrrolidone
  • Sorbitol is an aliphatic alcohol with a sweet taste. It is used in cosmetics as a moisturizing component, significantly affects the texture of the product, giving it special softness, plasticity and velvety. Registered as food supplement E420.
  • Sodium carboxymethyl cellulose (Cellulose Gum) - a hydrocoloid, has emulsifying, thickening, foaming, stabilizing, softening, gelling and film-forming properties.
  • Hydrated Silica (Hydrated Silica) - a weak abrasive, a thickener, has a soft, gentle effect.
  • Polyvinylpyrrolidone is a thickener and gelling agent.
  • Sodium lauryl sulfate (Sodium Lauryl Sulfate) has a pronounced cleansing and foaming ability.
  • Polysorbate 80 (Polysorbate 80) - nonionic surfactant, emulsifier, solubilizer.
  • the proposed boundaries of the quantitative ratios of the introduced components provide the creation of liquid (elixir, rinse) and thick (toothpastes or gels) products for the care of the oral cavity and teeth.
  • cosmetics obtained on the basis of the claimed composition of the components have high physicochemical parameters for stability, appearance, and also have a highly effective effect on inhibiting bacterial growth, preventing and treating caries, and strengthening tooth enamel and gums.
  • Inhibition of the growth of Streptococcus mutans and Lactobacillus acidophilus, responsible for the occurrence of plaque, caries and inflammatory processes in the oral cavity is achieved by enhancing the synergistic effect of the use of a special complex consisting of methyl salicylate, anethole, essential oils of eucalyptus, peppermint and sweet orange.
  • Remineralization and restoration of tooth enamel, neck of teeth and reduction of tooth sensitivity is achieved by a special complex of components, not of animal origin, but specially composed of calcium, magnesium, potassium, sodium ions, as well as from a number of plant extracts containing manganese, iron, zinc, copper and trace elements.
  • Reducing inflammation and bleeding of the gums is achieved by a combination of extracts of aloe leaves or sage, oak bark, rowan and sea buckthorn fruits, calamus rhizomes, chamomile flowers, cloves and bearberry leaves.
  • Strengthening gums is achieved by a combination of extracts of oak bark, fruits of mountain ash and sea buckthorn, calamus rhizomes.
  • the tool is prepared as follows.
  • aqueous solutions and compositions are preliminarily prepared: an aqueous solution of disodium EDTA; aqueous dye solution CI 42090; composition of mineral salts and additives: (calcium chloride, magnesium chloride, potassium chloride, sodium chloride, calcium glycerophosphate, sodium benzoate, sodium saccharin, aloe leaf extract).
  • composition of essential oils and extracts of medicinal plants (eucalyptus oil, orange oil, peppermint oil, menthol, methyl salicylate, anethole, oak bark extract, calamus rhizome extract, chamomile flower extract, mountain ash fruit extract, clove extract, bearberry leaf extract, sea buckthorn fruit extract, polysorbate 80).
  • the following are sequentially loaded into the reactor: purified water (minus the amount for the preparation of aqueous solutions); an aqueous solution of disodium EDTA; composition of mineral salts and additives; sorbitol.
  • the liquid is stirred for 10-20 minutes. until complete dissolution of the composition of mineral salts and additives. Ethyl alcohol is then charged into the reactor. The liquid is stirred for 5-10 minutes. and load the composition of essential oils and extracts of medicinal plants and an aqueous solution of the dye CI 42090. The liquid is stirred for 1 to 2 hours. Stand for at least 3 days and filter.
  • the prepared tooth elixir is checked for compliance with organoleptic and physico-chemical indicators: appearance, color, smell, taste, pH, density, mass fraction of ethyl alcohol, volume fraction of ethyl alcohol. If the indicators comply with the norm, the dental elixir is served on the packaging.
  • the tooth elixir is a homogeneous transparent liquid of light green color with a fresh, pleasant smell with notes of mint and eucalyptus and a pleasant taste characteristic of this appellation.
  • a dental elixir is prepared as described in Example 1.
  • the elixir is a homogeneous liquid of light green color with a fresh, pleasant smell with notes of mint and eucalyptus and a pleasant taste characteristic of this appellation.
  • the tool is prepared as follows.
  • Auxiliary solutions and compositions are pre-prepared: - aqueous solutions of disodium salt of EDTA, dye CI 42090, dye CI 19140, sodium lauryl sulfate, sodium fluoride; - composition of mineral salts and additives: (calcium chloride, magnesium chloride, potassium chloride, sodium chloride, calcium glycerophosphate, sodium benzoate, sodium saccharinate, aloe extract; - composition of essential oils and extracts of medicinal plants (eucalyptus oil; orange oil; peppermint oil; menthol; methyl salicylate, anethole; clove extract, oak bark extract; calamus rhizome extract; chamomile flower extract; mountain ash fruit extract; bearberry leaf extract; sea buckthorn fruit extract; polysorbate 80).
  • titanium dioxide dye (CI 77891) is charged to the reactor. Mix and homogenize. Gelling agents are loaded - polyvinylpyrrolidone; mix and homogenize; sodium carboxymethyl cellulose; mix and homogenize.
  • a thickener, hydrated silica, is charged in portions. Mix and homogenize.
  • a composition of essential oils and extracts of medicinal plants peppermint oil; aqueous dye solution CI 42090; an aqueous solution of the dye CI 19140. Mix and homogenize.
  • an aqueous solution of sodium lauryl sulfate is charged to the reactor. Mix and homogenize. The mass is evacuated and cooled to a temperature of 30 ⁇ 2 ° C. The prepared mass of toothpaste is checked for compliance with organoleptic and physico-chemical indicators: appearance, color, smell, taste, pH.
  • the toothpaste is packaged.
  • Toothpaste is a homogeneous gel-like mass of light green color with a fresh, pleasant smell with notes of mint and eucalyptus and a pleasant taste characteristic of this appellation.
  • Toothpaste is prepared in the same way as described in example 5. It is a homogeneous gel-like mass of light green color with a fresh, pleasant smell with notes of mint and eucalyptus and a pleasant taste characteristic of this appellation.
  • Toothpaste is prepared as follows
  • eucalyptus oil orange oil; peppermint oil; menthol; methyl salicylate, anethole; clove extract; core extract oak; extract of calamus rhizome; extract of chamomile flowers
  • an aqueous solution of sodium lauryl sulfate is charged to the reactor. Mix and homogenize. The mass is evacuated and cooled to a temperature of 30 ⁇ 2 ° C. The prepared mass of toothpaste is checked for compliance with organoleptic and physico-chemical indicators: appearance, color, smell, taste, pH. If the indicators correspond to the norm, the toothpaste is packaged.
  • Toothpaste is a homogeneous pasty mass of light green color with a fresh, pleasant smell with notes of mint and eucalyptus and a pleasant taste characteristic of this appellation.
  • Example 6 Toothpaste
  • Toothpaste is prepared in the same way as described in example 5. Toothpaste is a homogeneous pasty mass of light green color with a fresh, pleasant smell with notes of mint and eucalyptus and a pleasant taste characteristic of this appellation.

Abstract

La présente invention se rapporte au domaine des substances cosmétiques pour le soin de la cavité buccale. La substance de la présente invention comprend un complexe spécial comprenant du salicylate de méthyle, de l'acétone, des huiles essentielles d'eucalyptus, de menthe et d'orange douce, laquelle possède des propritétés antimicrobiennes et empêche le développement de Streptococcus mutans et de Lactobacillus acidophilus qui sont responsables de la formation de carries et de processus inflammatoires de la cavité buccale. Cette substance comprend en outre un complexe de composants de reminéralisation comme les ions de calcium, de magnésium, de potassium, de sodium, ainsi que des extraits végétaux contenant des micro-éléments ayant une action reminéralisante, de restauration de l'émail dentaire et de diminution de la sensibilité dentaire. La composition d'extraits végétaux de feuilles d'aloès et d'arcostaphylos, d'écorce de chêne, de baises de sorbier et d'argousier, de racine d'acorus, d'oeillet et de fleurs de marguerite réduit les inflammations et le saignement des gencives, désinfecte la cavité buccale et améliore l'état des gencives.
PCT/IB2018/059200 2018-11-09 2018-11-22 Composition cosmétique pour le soin de la cavite buccale WO2020095099A1 (fr)

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LVP-18-85 LV15495B (lv) 2018-11-09 Līdzeklis mutes dobuma kopšanai

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114306141A (zh) * 2021-12-31 2022-04-12 赣南医学院 一种漱口水用活性组合物和漱口水及其制备方法
EP4335431A1 (fr) * 2023-07-25 2024-03-13 Instituto de Dermatologia Ignacio Umbert, S.L. Composition des sels de magnésium

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