JP2003012483A - Composition for oral cavity application - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a composition for oral cavity application, having excellent bactericidal and antibacterial effect in the oral cavity, giving little stimulation, having excellent usability and effective for the prevention and treatment of periodontosis. SOLUTION: The composition for oral cavity application contains mastic and ethanol.

Description

Detailed Description of the Invention

[0001]

TECHNICAL FIELD The present invention relates to an oral composition which is excellent in sterilizing and antibacterial effects in the oral cavity, has less irritation, is excellent in usability, and is effective in preventing and treating periodontal disease.

[0002]

2. Description of the Related Art It is generally known that caries and periodontal disease involve gram-negative bacteria such as Streptococcus mutans and Porphyromonas gingivalis. In dental caries, Streptococcus mutans forms plaque on the tooth surface, decomposes various sugars to produce organic acids such as lactic acid and citric acid, and stays in dental plaque to decalcify enamel. Occur. In addition, plaque is deposited and the anaerobic environment is adjusted, and periodontopathic bacteria such as Gram-negative bacteria are established.
Along with the proliferation, periodontitis occurs due to toxins, inflammatory substances, etc. that produce bacteria, and eventually periodontal disease occurs.

In order to prevent and treat dental caries and periodontal diseases, bactericides such as chlorhexidine and cetylpyridinium chloride have been conventionally incorporated into oral compositions such as dentifrices and mouthwashes. These bactericides have an excellent bactericidal effect, but have problems such as irritation, and their improvement has been desired.

Since ethanol has an excellent bactericidal effect and a refreshing feeling after use, ethanol has been conventionally blended in oral compositions such as mouth rinses.

Furthermore, since mastic has a bactericidal / antibacterial effect against anti-H. Pylori bacteria, it has been blended in foods such as gums.

[0006]

However, when a large amount of ethanol is added to the oral composition, harmful effects in use such as strong irritation are caused, and when a small amount of ethanol is used, it causes germs of periodontal disease. On the other hand, a sufficient bactericidal effect cannot be obtained. Further, mastic has a peculiar taste like cypress, and if a large amount is added to the oral composition in order to sterilize the bacteria causing periodontal disease, there is a problem in usability.

[0007]

In view of such circumstances, the present inventors have a sufficient effect on the causative bacteria of periodontal disease,
Little irritation, excellent usability, as a result of repeated intensive studies to obtain an oral composition effective for the prevention and treatment of periodontal disease, by containing mastic and ethanol, to solve the above problems The inventors have found the present invention and have reached the present invention. That is, the present invention is a composition for oral cavity containing mastic and ethanol.

[0008]

BEST MODE FOR CARRYING OUT THE INVENTION Embodiments of the present invention will be described below. The mastic used in the present invention is a mastic tree (Pistacia Lentis) which is an evergreen tree of the family Rhusidae distributed from the Mediterranean coast to Morocco and the Canary region.
This is a sample of the sap flowing out after damaging the bark of cus L.). This sap hardens over time. Since it has a bactericidal and antibacterial effect against anti-Pylori bacteria, it has been incorporated into foods such as gums. Examples of the commercially available mastic suitable for the present invention include Gum Mastic Oil (manufactured by San Aroma Co., containing 40 mass% mastic).

The amount of mastic blended is 0.001 to 10 based on the total amount of the composition from the viewpoint of feeling of use and bactericidal / antibacterial effect.
Mass% is preferred.

The amount of ethanol used in the present invention is preferably 5 to 20% by mass of the total composition from the viewpoint of safety such as mucous membrane irritation, accidental ingestion, and bactericidal / antibacterial effects.

The oral composition of the present invention contains, in addition to the above-mentioned essential components, other components usually added to the oral composition, such as a plant extract, a polishing agent, a wetting agent, a surfactant, and a surfactant. It is possible to add a sticking agent, a flavor, a sweetener, a coloring agent, a preservative, a pH adjusting agent, various medicinal components and the like in a usual dose within a range that does not impair the effects of the present invention.

The plant extracts include mugwort, nutmeg,
Yakusou, areca, shikon, licorice, sardine, psyllium, tea, keihi, clove, oak, aloe, ginger, ginkgo, pomegranate, safflower, mentha, eucalyptus, gemweed, goldfish, sprout, genus ginkgo, juniper, biwa, juniper, juniper, moth , Yukinoshita, forsythia, birch, hops, lavender, lemon, sprout, bear mackerel, sausage, hypericum, tomoesou, arnica, chamomile, chinko, burdock, pearl calendula, calendula, cornflower, roman chamomile, orensis, salmon roe, salmon, daisy-breasted, salamander
Thyme, mint, honeysuckle, fennel, senkyu, horse chestnut, horse chestnut, rose, salamander, and the like.

As the abrasive, aluminum oxide, aluminum hydroxide, aluminum silicate, zirconium silicate, silicic acid anhydride, precipitated silica, silica gel, calcium carbonate, calcium pyrophosphate, calcium hydrogen phosphate, calcium phosphate, tricalcium phosphate. , Hydroxyapatite, fluoroapatite, halogenated apatite, magnesium carbonate, magnesium phosphate, insoluble sodium metaphosphate, insoluble calcium metaphosphate, titanium oxide, zeolite, synthetic resin abrasives and the like.

As the wetting agent, glycerin, sorbitol, ethylene glycol, propylene glycol, 1,
3-butylene glycol, polyethylene glycol, polypropylene glycol, dipropylene glycol, maltitol, xylitol, lactitol and the like can be mentioned.

Examples of the surface active agent include anionic surface active agents, cationic surface active agents, amphoteric surface active agents, nonionic surface active agents, and the like. Specific examples are alkyl sulfates, alkylbenzene sulfonates, and sucrose fatty acids. ester,
Lactose fatty acid ester, lactitol fatty acid ester, maltitol fatty acid ester, sodium lauryl sulfate, sodium lauroyl sarcosine, sodium α-olefin sulfonate, N-acyl glutamate, 2
-Alkyl-N-carboxy-N-hydroxyethylimidazolinium betaine, N-acyl taurate, alkylol amide, pluronic, polyoxyethylene hydrogenated castor oil or its fatty acid ester, polyoxyethylene sorbitan fatty acid ester, polyglycerin fatty acid ester , Sorbitan fatty acid ester, fatty acid ester, polyethylene glycol fatty acid ester, propylene glycol fatty acid ester and the like.

Examples of the thickener include hydroxyethyl cellulose, sodium carboxymethyl cellulose, methyl cellulose, carrageenan, carboxyvinyl polymer, alkali metal alginates such as sodium polyacrylate and sodium alginate, gums such as xanthan gum, juramin gum, tragacanth gum, karaya gum and arabiya gum. Examples thereof include polyvinyl alcohol, polyvinylpyrrolidone, silica gel, aluminum silica gel, veegum, and laponite.

As the fragrance, menthol, orange oil,
Spearmint oil, peppermint oil, lemon oil, eucalyptus oil, peppermint oil, acacia oil, fennel oil, kuchento oil, columbus oil, camphor oil, cinnamon oil, cinnamon oil, cauliflower oil, rose oil, sandalwood oil, clove oil, Herbs oil, banana oil, apple oil, methyl salicylate, carvone, anethole, terpenes such as limonene, and mixed flavors can be mentioned.

Examples of sweeteners include saccharin, sodium saccharin, xylitol, stevioside, stevia extract, rebaudioside, paramethoxycinnamic aldehyde, neohesperidyl dihydroxychalcone, perillartin, thaumatin, glycyrrhizin, glycyrrhizin monoglucoside, and hernandultin. , Trehalose, aspartame, sorbit and the like.

Examples of the colorant include legal dyes such as blue color No. 1 and yellow color No. 4, titanium dioxide, caramel and the like.

Examples of preservatives include sodium benzoate, paraoxybenzoic acid esters, alkyldiaminoethylglycine hydrochloride and the like.

As the pH adjusting agent, citric acid, phosphoric acid,
Organic acids such as malic acid and acetic acid and salts thereof, sodium carbonate, sodium hydrogen carbonate, potassium carbonate, potassium hydrogen carbonate, ammonium carbonate, ammonium hydrogen carbonate, potassium sodium carbonate, lithium carbonate, urea, amino acid oligomer, calcium chloride, nitric acid calcium,
Inorganic calcium such as calcium sulfate, calcium glycerophosphate, calcium hydroxide, calcium lactate, calcium acetate, calcium malonate, calcium citrate, calcium glycolate, calcium glycerate,
Examples thereof include organic acid calcium such as calcium tartrate and calcium phytate.

Examples of medicinal components include allantoin, tocopherol acetate, isopropylmethylphenol, glycyrrhetinic acid, dextranase, chlorophyll, copper chlorophyll sodium, flavonoids, tranexamic acid,
Mutanase, lysozyme, amylase, protease,
Lytic enzyme, superoxide dismutase, epsilon aminocaproic acid, aluminum allantoin, aluminum chlorohydroxy allantoin, dihydrocholestanol, glycyrrhizinic acid, bisabolol, glycerophosphate, water-soluble inorganic phosphate compound, sodium fluoride, sodium monofluorophosphate, fluorine Fluoride such as tin fluoride, potassium fluoride, sodium fluorosilicate, aluminum fluoride, silver fluoride, hexylamine hydrofluoride, decanolamine hydrofluoride, octadecenylamine hydrofluoride, edet salts, zinc citrate, zinc chloride, copper gluconate, chlorhexidine gluconate, copper chloride, polyphosphates, pyrophosphates, vitamins a, C, E, B _6, vitamins such as pantothenic acid, glycine, Li Down, amino acids histidine, sodium chloride, sodium bicarbonate, aluminum lactate, potassium nitrate, sarcosinate, polyphenol compounds such as catechin, and the like.

Others include water, silicone substances,
A sugar alcohol, a natural extract and the like can be appropriately blended.

The oral composition of the present invention is blended together with the above-mentioned components by a conventional method, and powdered dentifrice, moisturizing dentifrice, toothpaste, liquid dentifrice, liquid dentifrice, mouthwash, mouthwash, etc. Can be prepared in various dosage forms. For example, in the case of producing a mouthwash, it can be produced by using the above components in an appropriate amount of the oral composition of the present invention or a mixture of the appropriate amount of the oral composition of the present invention and water. The mouthwash thus obtained can be used by being stored in a bottle-shaped container or the like.

[0025]

The present invention will be described in more detail with reference to the following examples, but the scope of the present invention is not limited to these examples. The compounding amount in the examples is% by mass.

A mouthwash was prepared by a conventional method using the compositions shown in Examples 1 to 7 and Comparative Examples 1 to 5 and evaluated for bactericidal / antibacterial properties against periodontal disease-causing bacteria, usability, and effect of improving periodontal disease. I went. Each evaluation method is as follows.

[0027]Sterilization / antibacterial Porphyromonas gingival, a typical cause of periodontal disease
1% of the adjusted bacterial solution (107 cfu / ml) of is is applied to the sample.
Seeded Yeast extract (Difco) and cotton sheep aseptic defibrinated blood added
Dilute with Brain Heart Infusion Agar
After pouring the sample into a sample and culturing it under anaerobic conditions,
The survival rate was calculated and evaluated. ○: The survival rate against the number of bacteria at the time of inoculation is less than 0.01%. Δ: Survival rate against the number of bacteria at the time of inoculation is 0.01% or more, 1
%Less than. X: Survival rate against the number of bacteria at the time of inoculation is 1% or more.

[0028]Usability (no irritation and taste) 10 sensory panelists rinsed their mouths with samples and stimulated at that time
The dryness and taste were evaluated. ◯: More than 8 out of 10 people have no irritation and no problem with taste
Answer. Δ: 5 to 7 out of 10 people have no irritation and have no problem in taste
Answer. X: 4 or less out of 10 people have no irritation and have no problem in taste
Answer.

[0029]Improvement effect of periodontal disease 10 panelists with periodontal disease sampled once a day before going to bed
Rinse mouth and use for 1 month to improve periodontal disease
evaluated. ○: 7 or more out of 10 answered that the improvement effect was seen. Δ: 4 to 6 out of 10 answered that the improvement effect was seen. ×: 3 or less out of 10 answered that the improvement effect was seen.

[0030]

[Table 1]

[0031]

[Table 2] "Example 8: Mouthwash" Ethanol 15.0 mass% Mastic 3.0 Sorbitol 10.0 Licorice extract 4.5 Polyglycerin fatty acid ester 5.0 l-Menthol 0.1 Citric acid 0.01 Sodium citrate 0.05 Fragrance Appropriate amount Purified water Residue A mouthwash was manufactured by a conventional method with the above formulation.

[0032]           "Example 9: Toothpaste"           Ethanol 5.0 mass%           Mastic 0.5           Concentrated glycerin 20.0           Sodium lauryl sulfate 1.5           Polyoxyethylene sorbitan fatty acid ester 2.0           Silicic anhydride 3.0           Aluminum hydroxide 18.0           Carboxymethyl cellulose 0.5           Carrageenan 0.5           Spearmint oil 0.1           Sodium dihydrogen phosphate 0.05           Aroma           Purified water residue A dentifrice was manufactured by the conventional method with the above formulation.

[0033]

As described above, the present invention has excellent sterilization and antibacterial effects in the oral cavity, little irritation, and excellent usability.
An oral composition effective for prevention and treatment of periodontal disease can be provided.

   ─────────────────────────────────────────────────── ─── Continued front page    (72) Inventor Noriyuki Oikawa             Kanagawa Prefecture Toyama City Totsuka Ward Shinano 12-13 shares             FANCL Central Research Institute (72) Inventor Takamasa Hitomi             Kanagawa Prefecture Toyama City Totsuka Ward Shinano 12-13 shares             FANCL Central Research Institute F-term (reference) 4C083 AA111 AA112 AB172 AB222                       AB282 AC092 AC101 AC102                       AC122 AC132 AC302 AC422                       AC442 AC782 AD272 AD352                       BB41 BB44 BB48 CC41 DD17                       DD22 DD23 DD28 EE33 EE34                 4C088 AB21 AC08 BA37 MA02 MA17                       MA22 MA28 MA43 MA57 NA05                       NA06 NA08 NA09 ZA67 ZB35                 4C206 AA01 AA02 CA03 MA02 MA04                       MA37 MA77 NA05 NA06 NA08                       NA09 ZA67 ZB35

Claims (3)

[Claims] 1. An oral composition comprising mastic and ethanol. 2. A mastic content of 0.001-1
The composition for oral cavity according to claim 1, wherein the composition is 0% by weight. 3. The oral composition according to claim 1, wherein the blending amount of ethanol is 5 to 20% by weight.