JP2012097018A - Anti-dental caries agent, antiseptic agent, composition for oral cavities and composition - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide an anti-dental caries agent that is high in safety and can sufficiently control bacteria related to dental caries; to provide an antiseptic agent that can be compounded with a wide range of daily necessaries including compositions for oral cavities, external preparations for skins, and quasi-drugs, is safe, and is useful for preventing the growth and proliferation of microorganisms to maintain the qualities of products well; and to provide a composition compounded with the anti-dental caries agent or the antiseptic agent.SOLUTION: There are provided: the anti-dental caries agent characterized by containing a condensed phosphate and a mastic processed agent as active ingredients; the antiseptic agent characterized by containing a condensed phosphate and a mastic processed agent as active ingredients; a composition for oral cavities, containing the anti-dental caries agent; a composition containing the antiseptic agent; a bacteriostatic agent characterized by containing a condensed phosphate and a mastic processed agent as active ingredients; a composition containing the bacteriostatic agent.

Description

  The present invention relates to an anti-cariogenic agent and an antiseptic, and more specifically, an anti-cariogenic agent which exhibits an excellent anti-cariogenic effect and is highly safe and can be blended in an oral composition, and an excellent anti-septic The present invention relates to a preservative that exhibits effects and is highly safe and can be blended in a wide range of daily necessities including oral compositions, external preparations for skin, and quasi drugs. The present invention further relates to an oral composition containing the above-mentioned anti-cariogenic agent and a composition containing the above-mentioned preservative. The preservative is also useful as a bacteriostatic agent, and the present invention also relates to a composition containing such a bacteriostatic agent.

In Japan, where the population is aging, the prevention and treatment of dental caries is a very serious problem. Bacteria known as caries-causing bacteria (caries-related bacteria) include the following.
Streptococcus mutans 6751
Streptococcus sanguis E206
Streptococcus mitis ATCC9811
Actinomyces viscosus ATCC15987 (Actinomyces viscosus ATCC15987)
Actinomyces neslundii ATCC12104 (Actinomyces naeslundii ATCC12104)
Lactobacillus casei ATCC393
As a treatment method for caries, a conventional dentifrice is used in addition to a mouthwash with a bactericide. However, since there are many dentifrices containing alcohol components and bactericides, and the bactericidal power is strong, even resident bacteria useful for living bodies are sterilized.

Conventionally, for example, an oral composition having an effect of suppressing periodontal disease-causing bacteria, which contains an extract of mastic (which refers to a resinous exudate of Pistachia lentiscus of Urushiaceae) has been proposed. (See Patent Document 1). In addition, oral stain removers and oral compositions containing ultraphosphate, which is a kind of condensed phosphate, have been proposed (see Patent Document 2).
While various oral compositions containing antibacterial components have been proposed, oral compositions containing components with excellent anti-cariogenic effects are required.

In addition, in daily necessities such as oral compositions and external preparations for skin, it is important to prevent contamination by microorganisms during storage. Invasion and growth of microorganisms within a certain period in so-called cosmetics and quasi-drugs such as oral cosmetics, basic cosmetics such as skin lotions and creams, makeup cosmetics, oral care cosmetics, and detergents and deodorants. Preservatives are used to prevent growth, prevent spoilage and fermentation, and maintain stable quality. Examples of fungi that generally cause spoilage and fermentation and make products unstable include so-called miscellaneous bacteria such as general bacteria such as E. coli, coliforms, Candida fungi, Pseudomonas aeruginosa, Staphylococcus aureus, etc. .
Most of the preservatives currently used are organic preservatives obtained by highly refining petroleum such as paraoxybenzoates (abbreviated parabens) and phenoxyethanol. Such preservatives suppress the growth and proliferation of a wide variety of bacteria and fungi, and increase the stability of the product. Moreover, in order to bacterize a wide variety of fungi, a plurality of types of preservatives are used in combination. On the other hand, there are concerns about safety of organic preservatives, and paraben substitutes have been proposed.
In recent years, while various preservatives have been proposed, a preservative that has higher safety, can be safely used in daily necessities, and has an excellent antiseptic effect has been demanded.

JP 2002-29982 A International Publication No. 2007/145287 Pamphlet

An object of the present invention is to provide an anticaries agent that is highly safe and can sufficiently inhibit caries-related bacteria.
The object of the present invention can also be incorporated into a wide range of daily necessities including oral compositions, topical skin preparations, quasi-drugs, etc., and is safe and prevents the growth and growth of microorganisms. It is to provide a preservative useful for maintaining good quality.
Another object of the present invention is to provide a composition containing the above-mentioned anti-cariogenic agent or preservative.
The active ingredient of the preservative is also useful as an active ingredient of a bacteriostatic agent. Therefore, the object of the present invention is to provide a composition containing such a bacteriostatic agent and the bacteriostatic agent. is there.

As a result of intensive studies to achieve the above-mentioned problems, the present inventors have used a condensed phosphate and a processed product of mastic (which refers to the resinous exudate of Pistachia lentiscus). As a result, the present inventors have found that it exhibits excellent antibacterial activity against anti-cariogenic bacteria, and has completed the present invention. Among the processed mastic products, it has been found that the antibacterial-related bacteria have excellent antibacterial properties by using a combination of essential oil and condensed phosphate.
The inventors of the present invention have also found that the combined use of condensed phosphate and processed product of mastic shows antibacterial activity against a plurality of microorganisms that are sources of contamination in so-called daily necessities, and to complete the present invention. It came. Among the processed mastics, it has been found that the antibacterial activity is exhibited against a plurality of microorganisms that are the source of contamination in so-called daily necessities, especially by using mastic essential oil and condensed phosphate in combination.
In this specification, the mastic essential oil means an essential oil obtained by subjecting mastic to a steam distillation method or a solvent extraction method.
Accordingly, the present invention is an anti-cariogenic agent characterized by containing a condensed phosphate and a processed mastic product as active ingredients.
The present invention also provides a preservative characterized by containing a condensed phosphate and a mastic processed product as active ingredients.
More specifically, as a result of extensive research on antibacterial properties of condensed phosphates and mastic processed products against anti-cariogenic bacteria, the present inventors have shown a high proportion of antibacterial-related bacteria. I found. Moreover, the compounding ratio which can exhibit and maintain bacteriostatic power and antibacterial power in various products as antiseptic | preservatives of condensed phosphate and a mastic processed product was discovered.

Examples of processed mastic used in the present invention include solidified mastic (for example, powder), oily extract (for example, dissolved in coconut oil), dissolved in nonionic surfactant, and purified by organic solvent. Examples include solids (for example, powders) obtained by evaporating ethanol after removing impurities by filtering or the like after dissolving mastic in ethanol, for example, and mastic essential oil. Of these, mastic essential oil is preferable.
Examples of the condensed phosphate used in the present invention include at least one selected from the group consisting of polyphosphates, metaphosphates and ultraphosphates. In a preferred embodiment of the present invention, the average degree of polymerization of phosphoric acid residues of the condensed phosphate is in the range of 4-30.

The above-mentioned anticaries can be used as a caries preventive or caries treatment. The present invention is further directed to an oral composition containing the above-mentioned anti-cariogenic agent. Thus, the present invention is also an oral composition containing a condensed phosphate and a processed mastic product.
The above-mentioned preservative can be blended in a wide range of daily necessities including oral compositions, external preparations for skin, and quasi drugs. Therefore, the present invention is directed to a composition containing the above preservative. Specific examples of the composition include oral compositions, external preparations for skin, quasi drugs, detergents and deodorants. Specifically, the present invention includes an oral composition containing a condensed phosphate and a processed mastic product, an external preparation for skin containing a condensed phosphate and a processed mastic product, a quasi drug, and the like. Is directed to.
The present invention is also directed to a bacteriostatic agent comprising a condensed phosphate and a processed mastic product as active ingredients, and a composition containing the bacteriostatic agent, such as a detergent or a deodorant.

The anti-cariogenic agent of the present invention can exhibit an excellent antibacterial action against caries-related bacteria due to the synergistic effect of the condensed phosphate, which is an active ingredient, and the processed mastic product. Therefore, the anti-caries agent of this invention can provide the composition for oral cavity which can exhibit the outstanding anti-caries effect by mix | blending with a comparatively low density | concentration to an oral composition.
The preservative of the present invention has a synergistic effect between the active phosphate, which is an active ingredient, and a processed mastic product. Fungi such as Escherichia coli and Candida, a wide range of general bacteria such as Pseudomonas aeruginosa and Staphylococcus aureus In contrast, it exhibits excellent antibacterial action.
The active ingredient of the anti-cariogenic agent or antiseptic of the present invention is highly safe. The preservative of the present invention can be widely blended in daily commodities compositions. The preservative of the present invention, when blended at a relatively low concentration in oral compositions, external preparations for skin, quasi drugs, etc., prevents the growth and growth of microorganisms in the product and maintains good product quality. can do.
The active ingredient of the bacteriostatic agent of the present invention is also highly safe. The bacteriostatic agent of the present invention can be widely blended in daily commodities compositions, for example, blended with a detergent or deodorant to suppress the growth of bacteria in articles or places to which the detergent or deodorant is applied. Can exhibit excellent bacteriostatic action.

In Test Example 4, it is a graph showing antibacterial activity against Escherichia coli when sodium ultraphosphate and mastic essential oil are combined. In Experiment 4, it is a graph showing the antibacterial property with respect to colon_bacillus | E._coli at the time of combining sodium polyphosphate and mastic essential oil. In Experiment 4, it is a graph showing the antibacterial property with respect to a mutans bacterium by sodium ultraphosphate or sodium polyphosphate each independently. In Experiment 4, it is a graph showing the antibacterial property with respect to a mutans microbe at the time of combining various condensed phosphates and mastic essential oil. In Experiment 5, it is a graph showing the antiseptic effect with respect to colon_bacillus | E._coli by the mouthwash liquid which mix | blended the mastic essential oil and the ultraphosphate. In Experiment 6, it is a graph showing the antiseptic effect with respect to Pseudomonas aeruginosa of a mastic essential oil and an ultraphosphate. In Experiment 7, it is a graph showing the antiseptic effect with respect to Candida bacteria by the mouthwash liquid which mix | blended the mastic essential oil and the ultraphosphate. In Experiment 8, it is a graph showing the antiseptic effect with respect to Staphylococcus aureus by the mouth-washing liquid which mix | blended the mastic essential oil and the ultraphosphate.

The condensed phosphate which is one of the active ingredients in the anti-cariogenic agent, preservative and bacteriostatic agent of the present invention is a phosphate produced by polymerization of two or more PO ₄ tetrahedra sharing oxygen atoms. Say. Condensed phosphates are classified into polyphosphates, metaphosphates, and ultraphosphates based on the molar ratio of M ₂ O / P ₂ O ₅ (M is a monovalent metal).
In the present invention, at least one selected from polyphosphate, metaphosphate and ultraphosphate can be used as the condensed phosphate.
The polyphosphate has a M ₂ O / P ₂ O ₅ molar ratio (R) of 2>R> 1, and the general formula:
M _{n + 2} P _n O _{3n + 1}
(In the formula, n represents an integer of 2 or more.)
It has a linear structure.
The metaphosphate has a M ₂ O / P ₂ O ₅ molar ratio (R) of R = 1, and has the general formula:
(MPO ₃ ) _n
(In the formula, n represents an integer of 3 or more.)
It has a cyclic or extremely long linear structure. The polyphosphate and metaphosphate may be collectively referred to as polyphosphate.

The ultraphosphate has a molar ratio (R) of M ₂ O / P ₂ O ₅ of 1>R> 0, and the general formula: xM ₂ O · yP ₂ O ₅
(Wherein x and y are 0 <x / y <1)
It has a crosslinked structure having a branched PO ₄ group in the molecule, and has a unique structure as compared with the polyphosphate and metaphosphate.
Examples of salts of these condensed phosphates include sodium salts and potassium salts, and sodium salts are preferably used.

The condensed phosphate can be synthesized by a known production method.
The condensed phosphate is also commercially available, and a commercially available product can be used in the present invention. Examples of commercial products include, for example, trade name: sodium metaphosphate (average degree of polymerization of phosphoric acid residue: 30) manufactured by Taihei Chemical Industry Co., Ltd. as a polyphosphate, and for example, Mitsima Chemical as an ultraphosphate. Product name: Sodium Ultraphosphate (average degree of polymerization of phosphate residues: 15), etc.
The molecular weight range of the condensed phosphate used in the present invention is not particularly limited, but from the viewpoint of better exerting the intended effects of the present invention, the molecular weight range is defined as the average degree of polymerization of phosphate residues. Is suitably in the range of 4-60, preferably in the range of 4-30.
In the present invention, among the condensed phosphates, ultraphosphates can be preferably used.
The method for fractionating the condensed phosphate having a specific average degree of polymerization is not particularly limited. For example, for ultraphosphate, a method as described in WO 2007/145287. Can be adopted.

Other active ingredients in the anti-cariogenic agent, antiseptic agent and bacteriostatic agent of the present invention are processed mastic products. Specific examples thereof include solidified mastic (for example, powder), oily extract (for example, palm oil). Dissolved in non-ionic surfactant), purified product with organic solvent (mastic dissolved in ethanol, for example, filtered to remove impurities, and solid obtained by evaporating ethanol ( For example, powdery)), and mastic essential oil.
In the present invention, mastic essential oil can be particularly preferably used. Mastic essential oil can be obtained by subjecting mastic to steam distillation or solvent extraction.
The steam distillation method for obtaining mastic essential oil is not particularly limited. Typically, as a steam distillation method, water vapor is continuously introduced into a distillation vessel to expose the mastic to water vapor, the distillation vessel is heated to fill the vessel with heated water vapor, and the heated water vapor flowing out is cooled with a water-cooled tube. Cooling and collecting the essential oil together with water, and collecting the essential oil floating on the top. Moreover, the conventional steam distillation method employ | adopted as the extraction method of the essential oil from a plant can be implemented. Various conditions in the steam distillation method, for example, the apparatus, steam pressure, temperature, time and the like can be selected as appropriate.
Moreover, ethanol, hexane, benzene, acetone etc. are mentioned as a solvent used with the solvent extraction method for obtaining mastic essential oil.
Mastic essential oil is also available, for example, under the trade name “100% pure Mastic Oil” (essential oil by steam distillation, manufacturer: THE CHIOS GUM MASTIC GROWERS ASSOCIATION).
Mastic essential oil is a colorless to pale yellow viscous liquid, and contains α-pinene, β-myrcene, β-pinene, limonene, camphene and the like.

The anti-cariogenic agent of the present invention contains a condensed phosphate and a processed mastic product as active ingredients. Below, a mastic essential oil is mentioned and demonstrated as a typical example of a mastic processed product.
In the anti-cariogenic agent, the mixing ratio of condensed phosphate and mastic essential oil is suitably 0.05 to 20 parts by mass of mastic essential oil with respect to 1 part by mass of condensed phosphate, preferably mastic. The essential oil is 0.1 to 15 parts by mass, and more preferably 0.1 to 10 parts by mass.
In addition to the above active ingredients, appropriate additives can be blended in the anti-cariogenic agent of the present invention.
The anticaries agent of the present invention can also be a component of an oral composition. Here, examples of specific forms of the oral composition of the present invention include toothpastes, toothpastes, liquid dentifrices, moisturizing dentifrices, liquid dentifrices and other toothpastes, mouthwashes (mouthwashes) ), Water toothpaste, mouth freshener, mouth rinse, mouthwash tablet, ointment preparation, cream preparation, patch, oral beauty agent, chewing gum and the like. The dosage form of the oral composition may be any of solid, paste, gel, jelly, liquid and the like.

The antiseptic | preservative of this invention contains a condensed phosphate and a mastic processed product as an active ingredient. Below, a mastic essential oil is mentioned and demonstrated as a typical example of a mastic processed product. In the preservative, the mixing ratio of condensed phosphate and mastic essential oil is suitably 0.05 to 20 parts by mass of mastic essential oil, preferably mastic, relative to 1 part by mass of condensed phosphate. It is 0.1-15 mass parts of essential oil, More preferably, it is 0.1-10 mass parts of mastic essential oil.
In addition to the above active ingredients, appropriate additives can be blended with the preservative of the present invention.
The antiseptic of the present invention can also be incorporated into a wide range of daily commodities such as the above-mentioned oral compositions, skin external preparations, quasi drugs, detergents and deodorants, and microorganisms in the compositions Prevents growth and growth of the composition, prevents spoilage of the composition and helps maintain good product quality.

  The skin external preparation of the present invention is not particularly limited, and specifically includes a wide range of pharmaceutical external preparations, medicinal cosmetics (quasi-drugs), ordinary cosmetics such as cosmetics, cleaning products, and toiletry products. To do. Further, the external preparation for skin of the present invention can be in various forms, for example, basic cosmetics such as lotion, cream, milk lotion, pack, cosmetic liquid, makeup cosmetics such as lipstick and foundation, cosmetic oil, etc. Ointment; gel; antiperspirant deodorant, deodorant deodorant; hair and tonic, hair cream, hair mist, hair gel, hair shampoo, hair rinse, etc .; body cream; face wash, body lotion, body Examples of the cleaning agent include soap, cleansing, liquid soap, and solid soap. The dosage form of the composition in which the preservative of the present invention can be blended may be any of solid, paste, gel, jelly, and liquid.

  In the composition for oral cavity containing the anti-cariogenic agent or preservative of the present invention, the blending amount of the condensed phosphate and the mastic essential oil satisfies the mass ratio of both in the above-mentioned anti-cariogenic agent or preservative. It's okay. Specifically, the blending amount of the condensed phosphate is generally 0.001 to 10% by mass, preferably 0.005 to 5.0% by mass, more preferably, based on the total mass of the oral composition. Is 0.01-3.0 mass%. In the oral composition of the present invention, the blending amount of the mastic essential oil is generally suitably 0.001 to 3% by mass, preferably 0.01 to 2% by mass based on the total mass of the oral composition. %, More preferably 0.03 to 1.5% by mass.

  In a composition such as an external preparation for skin containing the preservative of the present invention, for example, the blending amount of the condensed phosphate and the mastic essential oil may satisfy the mass ratio of both in the preservative described above. Specifically, the blending amount of the condensed phosphate is generally appropriately 0.001 to 10% by mass, preferably 0.005 to 5.0% by mass, more preferably 0, based on the total mass of the composition. 0.01 to 3.0% by mass. In addition, in a composition such as an external preparation for skin containing the preservative of the present invention, the amount of mastic essential oil is generally suitably 0.001 to 3% by mass, preferably in the total mass of the composition, It is 0.01-2 mass%, More preferably, it is 0.03-1.5 mass%.

The oral composition of the present invention can be prepared according to conventional methods by appropriately selecting and blending conventionally used bases and additives according to various forms. Taking a dentifrice such as a toothpaste as an example, for example, the following bases and additives can be blended.
Abrasive: Silica-based abrasive such as crystalline silica, amorphous silica, other silicic anhydride, hydrous silicic acid, aluminosilicate, aluminum oxide, aluminum hydroxide, insoluble sodium metaphosphate, insoluble potassium metaphosphate, titanium oxide, Dibasic calcium phosphate dihydrate, dibasic calcium phosphate anhydrate, heavy calcium carbonate, light calcium carbonate, calcium pyrophosphate and the like. The abrasive is generally used in an amount of 3 to 99% by mass.

  As a binder, cellulose derivatives such as carrageenan, carboxymethylcellulose, sodium carboxymethylcellulose, methylcellulose, hydroxymethylcellulose, sodium carboxymethylhydroxymethylcellulose, alkali metal alginates such as sodium alginate, propylene glycol alginate, xanthan gum, tragacanth gum, caraya gum, gum arabic Use synthetic binders such as gums such as polyvinyl alcohol, sodium polyacrylate, carboxyvinyl polymer, and polyvinylpyrrolidone, and inorganic binders such as gelling silica, gelling aluminum silica, vegant, and laponite. Can do. The binder is generally used in an amount of 0.5 to 10% by mass.

  As a wetting agent, sorbit, glycerin, ethylene glycol, propylene glycol, 1,3-butylene glycol, polyethylene glycol, polypropylene glycol, xylit, malt, lactit, hydrolyzed collagen solution, sodium hyaluronate, trehalose, neotrehalose, isotrehalose, Carbohydrates containing a saccharide derivative of α, α trehalose such as α-maltosyl α, α-trehalose can be used. The wetting agent is generally used in an amount of 1 to 50% by mass.

  As surfactants, sodium lauryl sulfate, sodium α-olefin sulfonate, sodium dodecylbenzene sulfonate, sodium lauryl sulfoacetate, sodium N-lauroyl sarcosinate, N-acyl glutamate, sucrose fatty acid ester, polyoxyethylene cured Castor oil, polyoxyethylene polyoxypropylene block copolymer, alkyl glycosides, sorbitan fatty acid ester, polyoxyethylene sorbitan fatty acid ester, alkyldimethylamine oxide, and the like can be used. The surfactant is generally used in a blending amount of 0 to 5% by mass.

  pH adjusters include lactic acid, citric acid, glycolic acid, succinic acid, tartaric acid, malic acid and their salts, potassium carbonate, sodium bicarbonate, ammonium bicarbonate, potassium hydroxide, sodium hydroxide, monoethanolamine, triethanol An amine, 2-amino-2-methyl-propanediol, arginine, lysine, etc., or a mixture thereof can be used. The pH adjuster is generally used in an amount of 0 to 10% by mass.

Further optional sweeteners such as sodium saccharin, stevioside, glycyrrhizin, perilartin, thaumatin, aspartylphenylalanine methyl ester, p-methoxycinamic aldehyde, sucrose, fructose, sodium cyclamate; spearmint oil, peppermint oil, wintergreen oil Fragrances such as sassafras oil, clove oil, eucalyptus oil, sage oil, mayonnaise oil, thyme oil, lemon oil, orange oil, l-menthol, carvone, anethole, eugenol, thymol, methyl salicylate; benzoic acid, sodium benzoate, Preservatives such as p-hydroxypropyl benzoic acid, p-hydroxybutyl benzoic acid, lower fatty acid monoglyceride, paraben; quaternary ammonium salt, triclosa , Alkyldiaminoethylglycine hydrochloride, cetylpyridinium chloride, decalinium chloride, benzethonium chloride and other fungicides; enzymes such as ε-aminocaproic acid, dextranase, amylase, protease, mutanase, lytic enzyme, lysozyme; sodium monofluorophosphate , Fluorides such as potassium monofluorophosphate, sodium fluoride, ammonium fluoride, stannous fluoride; chlorhexidine salts, dihydrocholesterol, glycyrrhetin salts, glycyrrhetinic acid, chlorophyll, caropeptide, tocopherol acetate, azulene, lysozyme chloride, zeolite And anticalculus agents such as polyphosphoric acid, anti-plaque agents, potassium nitrate, aluminum lactate and the like can be added.
In addition, the addition amount of these arbitrary components can be made into a normal amount in the range which cannot prevent the effect of this invention.

In formulating the external preparation for skin of the present invention, bases and additives can be appropriately used depending on the dosage form and form.
Examples of the base and additive used in the external preparation for skin of the present invention include mineral oil, animal and vegetable oil, wax, fatty acid, fatty alcohol, ester oil, surfactant, wetting agent, polymer compound, animal and plant extract, and amino acid. Class, solvents, preservatives, ultraviolet absorbers, sequestering agents, antioxidants, pH adjusters, dyes / pigments, fragrances, and the like, and can be blended within a range that does not impair the effects of the present invention. Specific examples thereof are given below.

<Mineral oil>
Liquid paraffin, liquid isoparaffin, etc.
<Animal and vegetable oil>
Squalane, olive oil, camellia oil, wheat germ oil, jojoba oil, avocado oil, carrot oil, shea fat, palm oil, hydrogenated oil, horse oil, lanolins, egg yolk oil, clove oil, rosehip oil, lavender oil, mint Oil, spearmint oil, rosemary oil, etc.
<Wax>
Microcrystalline wax, solid paraffin, beeswax etc.

<Fatty acid>
Lauric acid, myristic acid, palmitic acid, stearic acid, oleic acid, isostearic acid and the like.
<Fat alcohol>
Lauryl alcohol, myristyl alcohol, cetanol, cetostearyl alcohol, stearyl alcohol, isostearyl alcohol, oleyl alcohol, hexyl decanol, behenyl alcohol, octyldodecanol, lanolin alcohol and the like.
<Ester oil>
Glyceryl tricaprylate, cetyl 2-ethylhexanoate, glyceryl tri-2-ethylhexanoate, isocetyl octanoate, isononyl isononanoate, ethylene glycol dioctanoate, tri (caprylic / capric acid) glycerin, isopropyl myristate, isopropyl palmitate, myristine Isocetyl acid, cetyl palmitate, dialkyl carbonate, etc.

<Surfactant>
Lauryl sulfate, alkyl sulfate, polyoxyethylene alkyl sulfate, tetradecene sulfonate, polyoxyethylene alkyl sulfosuccinate, lauroyl sarcosine salt, alkylmethyl-β-alanine salt, polyoxyethylene alkyl ether phosphate, Fatty acid soap, N-acyl glutamate, lauric acid diethanolamide, coconut oil fatty acid diethanolamide, alkyldimethylamine oxide, alkylmethyl taurate, alkylaminopropionate, polyoxyethylene alkyl ether carboxylate, alkyl phosphate, Alkyl glucoside, polyether-modified silicon, etc.
Alkyltrimethylammonium chloride, alkyltrimethylammonium bromide, amidoamine, dialkyldimethylammonium chloride.
Alkyl dimethyl acetate betaine, alkylamidopropyl betaine, alkyl carboxymethyl hydroxyethyl imidazolinium betaine.
Lecithin (soybean or egg yolk) derivative, propylene glycol fatty acid ester, glycerin fatty acid ester, polyoxyethylene glycerin fatty acid ester, polyglycerin fatty acid ester, sorbitan fatty acid ester, polyoxyethylene sorbitan fatty acid ester, polyoxyethylene sorbit fatty acid ester, polyoxyethylene Hardened castor oil, polyethylene glycol fatty acid ester, polyoxyethylene alkyl ether, polyoxyethylene polyoxypropylene alkyl ether, polyoxyethylene alkyl nonylphenyl ether, polyoxyethylene alkyl ether phosphate / phosphate.

<Wetting agent>
Propylene glycol, dipropylene glycol, 1,3-butylene glycol, 1,2-hexanediol, glycerin, diglycerin, isoprene glycol, polyethylene glycol, sorbitol, maltitol, trehalose, xylit, etc.
<Polymer compound>
Methyl cellulose, ethyl cellulose, carboxymethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, carboxyvinyl polymer, polyvinyl alcohol, polyvinyl pyrrolidone, cationized cellulose, cationized guar gum, sodium hyaluronate, sodium polyacrylate, xanthan gum, carrageenan and the like.

<Animal and plant extracts>
Placenta extract, hydrolyzed collagen, hydrolyzed keratin, hydrolyzed silk, hydrolyzed elastin, yeast extract, aloe extract, comfrey extract, peonies extract, perilla extract, assembly extract, hamamelis water, toad extract, hop extract, sage extract, maronier Extracts, peach leaf extract, Yukinoshita extract, Melissa extract, mugwort extract, rosemary extract, rice bran extract etc.
<Amino acids>
L-alanine, L-arginine, L-aspartic acid, L-glutamine, L-cysteine, L-serine, L-tyrosine, L-proline, pyrrolidone carboxylate, glycine and the like.

<Solvent>
Purified water, normal water, ethanol, isopropanol, benzyl alcohol, etc.
<Vitamins>
Vitamin A, retinol acetate, pyridoxine hydrochloride, pyridoxine dicaprylate, biotin, nicotinic acid, nicotinamide, benzyl nicotinate, riboflavin, calcium pantothenate, D-pantothenyl alcohol, ascorbic acid, ascorbyl palmitate, L-ascorbyl phosphate Magnesium, ergocalciferol, vitamin E, tocopherol acetate, natural vitamin E, etc.
<Preservative>
Methylparaben, ethylparaben, propylparaben, butylparaben, isobutylparaben, phenoxyethanol, bisabolol, hinokitiol, benzoic acid, sodium benzoate, salicylic acid, sodium salicylate, sorbic acid, potassium sorbate, undecylenic acid, pionein, lmenthol, d-camphor etc.

<Ultraviolet absorber>
Paraaminobenzoic acid, ethyl paraaminobenzoate, glyceryl paraaminobenzoate, 2-ethylhexyl paradimethylaminobenzoate, oxybenzone, dihydroxybenzophenone, dihydroxydimethoxybenzophenone, sodium dihydroxydimethoxybenzophenonesulfonate, sodium hydroxymethoxybenzophenonesulfonate, octyl salicylate and the like.
<Metal ion sequestering agent>
Edetic acid, edetate, trisodium ethylenediaminehydroxyethyl triacetate, diethylenetriaminepentaacetic acid, pentasodium diethylenetriaminepentaacetic acid, ethylenediaminetetrakis (2-hydroxyisopropyl) diolate, hydroxyethanedisulfonic acid, tetrasodium hydroxyethanedisulfonate, phytin Acid etc.
<Antioxidant>
Dibutylhydroxytoluene, butylhydroxyanisole, erythorbic acid, propyl gallate, octyl gallate, d-δ-tocopherol and the like.

Moreover, the bacteriostatic agent of this invention contains a condensed phosphate and a mastic processed product as an active ingredient. When a mastic essential oil is mentioned as a typical example of a processed mastic product, the blending ratio of the condensed phosphate and the mastic essential oil in the bacteriostatic agent is the same as that of the preservative. The bacteriostatic agent of the present invention can be used as a component of a detergent or a deodorant. Here, specific examples of the detergent include kitchen detergent and laundry detergent such as clothing. Specific examples of the deodorant include household deodorants such as trash, room, car, toilet, cloth, and clothing. The bacteriostatic agent of the present invention can exert a bactericidal effect at the application site.
In the detergent or deodorant, the amount of the condensed phosphate is generally 0.001 to 10% by mass, preferably 0.005 to 5.0% by mass, based on the total mass of the composition. More preferably, it is 0.01-3.0 mass%. Moreover, 0.001-3 mass% is suitable for the compounding quantity of a mastic essential oil generally in the total mass of a composition, Preferably it is 0.01-2 mass%, More preferably, it is 0.03-1. 5% by mass.
In the detergent and deodorant, components usually used in the detergent and deodorant can be appropriately blended. For example, surfactant, pH adjuster, enzyme, alkali agent, acid agent, abrasive, fluorescent brightener , Sequestering agents, anti-staining agents, solvents and the like.

  Compositions such as oral compositions, external preparations for the skin, quasi-drugs, detergents and deodorants according to the present invention can be produced in accordance with conventional methods according to their forms, and at appropriate stages of the production process. A condensed phosphate and a processed mastic product, for example, a mastic essential oil may be blended.

MICの値を比較したところ、ウルトラリン酸ナトリウムとポリリン酸ナトリウムとの間に大きな差はないことから、縮合リン酸塩を単独で使用した場合のミュータンス菌に対する抗菌性の強さはほぼ同程度であることがわかった。 Test example 1: Antibacterial test of various condensed phosphates against caries-related bacteria Test method: Diluted overnight culture solution of Streptococcus mutans JC2 strain, a caries-related bacterium, in heart infusion medium at 1/100 Various condensed phosphates were added to the bacterial solution so that the final concentrations were 0.0039%, 0.0078%, 0.0156%, 0.0313%, 0.0625%, and 0.125%. A 96-well plate was dispensed so that the bacterial solution containing each condensed phosphate was 0.2 mL, and a bacterial solution to which no condensed phosphate was added was also prepared and cultured at 37 ° C. for 18 hours. By measuring the turbidity of the culture solution, the cell growth degree after 18 hours of culture was measured.
The condensed phosphate used in the test is sodium polyphosphate, trade name: sodium metaphosphate (average degree of polymerization of phosphate residues: 30) manufactured by Taihei Chemical Industry Co., Ltd., and sodium ultraphosphate Is a trade name: sodium ultraphosphate (average polymerization degree of phosphate residues: 15) manufactured by Mitsima Chemical Co., Ltd.
Table 1 below shows the minimum growth inhibitory concentration (MIC) when mutans bacteria are cultured in a medium containing various condensed phosphates.
Table 1. Minimum growth inhibitory concentration (MIC) when mutans bacteria are cultured in a medium containing various condensed phosphates

Comparison of MIC values shows that there is no significant difference between sodium ultraphosphate and sodium polyphosphate, so the antibacterial strength against mutans is almost the same when condensed phosphate is used alone. It turns out that it is a grade.

ミュータンス菌の場合と同様、大腸菌においてもウルトラリン酸ナトリウムとポリリン酸ナトリウムとでMICの値に大きな差はなく、縮合リン酸塩を単独で用いた場合の抗菌性の強さはほぼ同程度であることがわかった。 Test Example 2: Antibacterial activity test of various condensed phosphates against Escherichia coli Test method: An overnight culture of Escherichia coli K12 strain was added to LB medium so that the dilution was 1/100, and the final concentration of 0.0039 was added to the bacterial solution. %, 0.0078%, 0.0156%, 0.0313%, 0.0625% and 0.125% were added with various condensed phosphates. A 96-well plate was dispensed so that the bacterial solution containing various condensed phosphates was 0.2 mL, and a bacterial solution to which the condensed phosphate was not added was prepared and cultured at 37 ° C. for 18 hours. By measuring the turbidity of the culture solution, the cell growth degree after 18 hours of culture was measured.
In addition, the condensed phosphate used for the test was the same sodium polyphosphate and ultraphosphate as those used in Test Example 1 above.
Table 2 below shows the minimum growth inhibitory concentration (MIC) when E. coli was cultured in a medium containing various condensed phosphates.
Table 2. Minimum growth inhibitory concentration (MIC) when E. coli is cultured in media containing various condensed phosphates

As in the case of S. mutans, there is no significant difference in the MIC value between sodium ultraphosphate and sodium polyphosphate in E. coli, and the antibacterial strength is almost the same when condensed phosphate is used alone. I found out that

Test Example 3: Antibacterial test of mastic essential oil against Escherichia coli and caries-related bacteria Test method:
An antibacterial test using E. coli was performed by the following method. Mastic essential oil was diluted in 7 steps from a final concentration of 2.0% to 0.0313% and added to LB medium. E. coli Escherichia coli K12 overnight culture solution is added to each culture solution to a dilution of 1/1000 (viable cell count of about 1 x 10 ⁵ ), and cultured at 37 ° C for 24 hours. The growth rate of the bacteria was measured by measuring the turbidity.
Moreover, the antibacterial test using the caries-related bacteria was performed by the following method. Mastic essential oil was diluted in seven stages from a final concentration of 1.0% to 0.0156% and added to the heart infusion medium. Add the overnight culture of mutans to each culture to a dilution of 1/1000, and incubate at 37 ° C for 24 hours, then measure the turbidity of the culture to determine the cell growth rate. Measured.
In addition, the mastic essential oil used for the test is a brand name “100% pure Mastic Oil” (manufactured by THE CHIOS GUM MASTIC GROWERS ASSOCIATION by a steam distillation method).

表４．ミュータンス菌に対するマスティック精油の抗菌性

表３より、大腸菌ではマスティック精油１％から２％で菌体増殖が大きく阻害されることが判る。また表４から、ミュータンス菌ではマスティック精油０．５％から１％で菌体増殖が大きく阻害されることが示されたが、大腸菌、ミュータンス菌ともに、低濃度のマスティック精油ではほとんど菌体の増殖に影響はなかった。 The test results are shown in Tables 3 and 4 below.
Table 3. Antimicrobial properties of mastic essential oil against Escherichia coli

Table 4. Antibacterial properties of mastic essential oil against mutans

From Table 3, it can be seen that in Escherichia coli, cell growth is greatly inhibited at 1% to 2% of mastic essential oil. Table 4 also shows that mutans bacteria greatly inhibits cell growth from 0.5% to 1% of mastic essential oil. Both Escherichia coli and mutans bacteria have almost no mastic essential oil. There was no effect on cell growth.

Test Example 4: Antibacterial test of Escherichia coli and caries-related bacteria using various condensed phosphates and mastic essential oil Test method: An antibacterial test using Escherichia coli was carried out by the following method. An overnight culture of Escherichia coli K12 strain was inoculated into LB medium at a dilution of 1/1000, and mastic essential oil was added thereto so that the final concentrations were 0%, 0.2% and 0.4%. Various condensed phosphates were added to the bacterial solution so that the final concentrations were 0.0156%, 0.0313%, 0.0625%, 0.125%, 0.25%, 0.5%, and 1%. A 96-well plate was dispensed so that the bacterial solution containing each condensed phosphate was 0.2 mL, and a bacterial solution to which no condensed phosphate was added was also prepared and cultured at 37 ° C. for 24 hours. By measuring the turbidity of the culture solution, the cell growth degree after 24 hours of culture was measured.
The antibacterial test using caries-related bacteria was conducted by the following method. An overnight culture of Streptococcus mutans JC2 strain is inoculated to a heart infusion medium at a dilution of 1/1000, and the final concentration is 0.0039%, 0.0078%, 0.0156%, 0.0313%, 0.0625%, 0.125% Various condensed phosphates were added. Dispense each bacterial solution containing condensed phosphate into a 96-well plate so that the volume is 0.2 ml, and also incubate the bacterial solution with no condensed phosphate added at 37 ° C for 24 hours. Was measured. Next, in order to confirm the effect of the combination of condensed phosphate and mastic essential oil, the overnight culture solution of Streptococcus mutans JC2 strain was inoculated into the heart infusion medium at a dilution of 1/1000, and Stick essential oil was added to a final concentration of 0.25%. Various condensed phosphates were added to the bacterial solution so that the final concentrations were 0.0156%, 0.0313%, 0.0625%, and 0.125%. Dispense each bacterial solution containing condensed phosphate into a 96-well plate so that the volume is 0.2 ml, and also incubate the bacterial solution with no condensed phosphate added at 37 ° C for 24 hours. Was measured.
In addition, the condensed phosphate used for the test was the same sodium polyphosphate and ultraphosphate as those used in Test Example 1 above. Further, the mastic essential oil used in the test is the same as that used in Test Example 3 above.

The test results are shown in FIGS. FIG. 1 is a graph showing a comparison of antibacterial properties against E. coli when sodium ultraphosphate and mastic essential oil are combined. From this graph, it can be seen that the synergistic antibacterial property due to the combined use with mastic essential oil appears remarkably from the vicinity of 0.0156 to 0.0313% sodium ultraphosphate concentration. FIG. 2 is a graph showing a comparison of antibacterial activity against Escherichia coli when sodium polyphosphate and mastic essential oil are combined. From this graph, it can be seen that the synergistic antibacterial property by the combined use with mastic essential oil appears remarkably from the vicinity of the sodium polyphosphate concentration of 0.0156 to 0.0313%.
FIG. 3 is a graph showing antibacterial activity against mutans by sodium ultraphosphate or sodium polyphosphate alone. It can be read that sodium ultraphosphate or sodium polyphosphate alone has a concentration of about 0.0039 to 0.0313% and does not significantly affect the cell growth.
FIG. 4 is a graph showing a comparison of antibacterial properties against mutans bacteria when various condensed phosphates and mastic essential oil are combined. As can be seen from the 0% concentration line of various condensed phosphates in FIG. 4, antibacterial activity was hardly observed at a concentration of 0.25% of mastic essential oil alone, whereas the concentration of various condensed phosphates. Synergistic antibacterial activity against mutans bacteria is observed with a combined use of 0.0156 to 0.0313%.
From the results shown in FIG. 1 to FIG. 4, synergistic antibacterial properties are exhibited and caries-related when the combined phosphate and mastic essential oil are used in combination according to the present invention rather than only the condensed phosphate. It is clear that it has sufficient antibacterial properties against bacteria or E. coli.

上記表５の通り、防腐剤を含まない洗口液を調製し、濾過滅菌した後、各最終濃度のマスティック精油（0, 0.0125, 0.025, 0.05, 0.2%）及びウルトラリン酸ナトリウム（0, 0.005, 0.01, 0.02%）を適宜組み合わせて添加して、各検体を作成した。
ここで用いたウルトラリン酸ナトリウムは、上記試験例１で用いたのと同様であり、及びマスティック精油は上記試験例３で用いたのと同様である。 Test Example 5: Proliferation inhibitory effect of Mastic essential oil and ultraphosphate on Escherichia coli Using Escherichia coli K12 strain, Mastic essential oil and ultraphosphate were added to the basic mouthwash preparation shown in Table 5 below. The synergistic effect was investigated.
Table 5 Composition of mouthwash without preservatives

As shown in Table 5 above, after preparing a mouthwash solution containing no preservative and sterilizing by filtration, each final concentration of mastic essential oil (0, 0.0125, 0.025, 0.05, 0.2%) and sodium phosphate (0, 0.005, 0.01, 0.02%) was added in an appropriate combination to prepare each specimen.
The sodium ultraphosphate used here is the same as that used in Test Example 1, and the mastic essential oil is the same as that used in Test Example 3.

To each specimen, E. coli preculture was added to the mouthwash so as to be diluted 1/250, and static culture was performed at 37 ° C. for about one month. Take a portion of the preparation at regular intervals, inoculate 10 microliters of a sample diluted appropriately with physiological saline on an LB agar medium, incubate overnight at 37 ° C, and visually determine the number of colonies that have grown. Measured.
FIG. 5 shows the number of viable cells after culturing E. coli for 8 days in a preparation containing sodium ultraphosphate and mastic essential oil at various concentrations. When mastic essential oil was added alone, the viable count was almost zero at 0.2% mastic essential oil concentration, but when combined with ultraphosphate, the antiseptic effect increased depending on the concentration, When the sodium ultraphosphate concentration is 0.005%, the mastic essential oil concentration is 0.05%. When the sodium ultraphosphate concentration is 0.01%, the mastic essential oil concentration is 0.0125%. And the synergistic effect of ultraphosphoric acid. In these treatment groups, the fungus bodies did not grow even after about one month, and the antiseptic effect was maintained.

Test Example 6: Growth inhibitory effect of mastic essential oil and ultraphosphate on Pseudomonas aeruginosa Pseudomonas aeruginosa strain PAO1-272 was used to examine the synergistic effect on antibacterial properties of mastic essential oil and ultraphosphate. Each final sample of Mastic essential oil (0, 0.05, 0.1, 0.2%) and sodium ultraphosphate (0, 0.02, 0.04, 0.06%) was added to sterilized physiological saline as appropriate. .
The sodium ultraphosphate used here is the same as that used in Example 1, and the mastic essential oil is the same as that used in Test Example 3.
Each specimen was pre-cultured with Pseudomonas aeruginosa and fully grown to a dilution of 1/250, followed by stationary culture at 37 ° C. for about one month. Take a portion of the culture solution at regular intervals, inoculate 10 microliters of a sample diluted appropriately with physiological saline on LB agar medium, incubate overnight at 37 ° C, and visually check the number of colonies grown. Measured with.
FIG. 6 shows the number of viable bacteria after culturing Pseudomonas aeruginosa in physiological saline containing sodium ultraphosphate and mastic essential oil at various concentrations for 6 days. When mastic essential oil was added alone, the viable count was almost zero at 0.2% mastic essential oil concentration, but when combined with ultraphosphate, the antiseptic effect increased, and ultraphosphate sodium concentration 0.004 %, Mastic essential oil 0.1% completely inhibited the growth of bacterial cells, and the synergistic effect of mastic essential oil and ultraphosphoric acid on the growth of Pseudomonas aeruginosa was confirmed. In these treatment groups, the fungus bodies did not grow even after about one month, and the antiseptic effect was maintained.

Test Example 7: Growth inhibitory effect of mastic essential oil and ultraphosphate on Candida fungus Synergistic effect of using Candida albicans 0579 strain and mastic essential oil and ultraphosphoric acid in the same manner as in Test Example 5 I investigated. As shown in Table 5 above, a mouthwash solution containing no preservative was prepared, sterilized by filtration, then each final concentration of mastic essential oil (0, 0.125, 0.25, 0.5, 1%) and sodium phosphate (0, 0.3%) was added in appropriate combination. A pre-cultured Candida bacterium and fully grown was added at a dilution of 1/250, followed by stationary culture at 30 ° C. for about one month. Take a portion of the preparation at regular intervals, inoculate 10 microliters of a sample diluted appropriately with physiological saline on a potato dextrose agar medium, incubate overnight at 30 ° C, and visually check the number of colonies grown. Measured with.
FIG. 7 shows the number of viable bacteria after Candida was cultured for 8 days in a preparation containing sodium ultraphosphate at each concentration and mastic essential oil. When mastic essential oil was added alone, the viable count was almost zero at 0.5% mastic essential oil concentration, but when combined with ultraphosphate, the antiseptic effect increased depending on the concentration, When 0.3% sodium ultraphosphate was added, the growth of the cells was completely inhibited at a concentration of 0.25% mastic essential oil, and the synergistic effect of mastic essential oil and ultraphosphoric acid on the growth inhibition of Candida was confirmed. When sodium ultraphosphate 1.5% was added, sodium ultraphosphate alone completely inhibited cell growth. In these treatment groups, the fungus bodies did not grow even after about one month, and the antiseptic effect was maintained.

Test example 8: Growth inhibitory effect of Staphylococcus aureus ATCC 6538 by Staphylococcus aureus strain using Staphylococcus aureus by mastic essential oil and condensed phosphate. As in Test Example 5, mastic essential oil and ultraphosphate are used as preservatives. The synergistic effect was investigated. As shown in Table 5, after preparing a mouthwash that does not contain preservatives and filter sterilization, each final concentration of mastic essential oil (0 to 0.2%) and sodium ultraphosphate (0, 0.06, 0.3, 0.6%) Was added respectively. Pre-cultured Staphylococcus aureus and fully grown were added at a dilution of 1/250, followed by stationary culture at room temperature of about 25 ° C. for about one month. Take a part of the preparation at regular intervals, inoculate a sample diluted appropriately with physiological saline on a dedicated agar medium prepared as follows in 10 microliters, and incubate overnight at a room temperature of about 25 ° C. The number of grown colonies was counted visually.

Composition of agar medium dedicated to Staphylococcus aureus
Tryptone 1g
Yeast extract 0.2g
MgSO ₄・ 7H ₂ O 0.1g
Distilled water 100mL
Agar 1.5g
FIG. 8 shows the viable cell count after culturing S. aureus in a preparation containing sodium ultraphosphate and mastic essential oil at various concentrations for 7 days. Sodium ultraphosphate and comparative sodium polyphosphate alone did not completely inhibit the growth of bacteria even at an addition concentration of 0.6%, but as shown in FIG. 8, mastic essential oil 0.2% and ultraphosphoric acid When sodium was combined, bacterial growth was completely suppressed at a condensed phosphate concentration of 0.06%.
From these results, it was shown that the combination of mastic essential oil and ultraphosphate has a sufficient antiseptic effect against Staphylococcus aureus. This antiseptic effect was maintained for one month after inoculation with the fungus.

Hereinafter, the present invention will be described with reference to production examples, but the present invention is not limited thereto. In the following formulation examples, the trade name “100% pure Mastic Oil” (essential oil by steam distillation, manufacturer: THE CHIOS GUM MASTIC GROWERS ASSOCIATION) was used as the mastic essential oil.
[Formulation Example 1]
In accordance with the following prescription (unit: mass%), a toothpaste (paste) was produced by a conventional method.
Condensed phosphate 0.5
(Product name manufactured by Mitsima Chemical Co., Ltd .: sodium ultraphosphate (average degree of polymerization of phosphate residues: 15))
Mastic essential oil 0.05
Dipotassium glycyrrhetinate 0.06
Calcium carbonate 25.0
Silica 5.0
Silicic anhydride 5.0
Sorbit liquid 15.0
Concentrated glycerin 15.0
Sodium carboxymethylcellulose 1.0
Fragrance 0.5
Purified water balance
(Total 100% by mass)

[Formulation Example 2]
A gel dentifrice was produced by a conventional method according to the following formulation (unit: mass%).
Condensed phosphate 0.5
(Product name: Taihei Chemical Industry Co., Ltd .: sodium metaphosphate (average degree of polymerization of phosphate residues: 30))
Mastic essential oil 0.05
Dipotassium glycyrrhetinate 0.05
Sorbit 20.0
Concentrated glycerin 5.0
Silicic anhydride 5.0
Ethanol 15.0
Xylitol 0.5
Sodium carboxymethylcellulose 3.0
Polyethylene glycol 400 0.3
l-Menthol 0.05
Purified water balance
(Total 100% by mass)

[Formulation Example 3]
A mouthwash (mouthwash) was produced by a conventional method according to the following formulation (unit: mass%).
Condensed phosphate 0.5
(Product name: Taihei Chemical Industry Co., Ltd .: sodium metaphosphate (average degree of polymerization of phosphate residues: 30))
Mastic essential oil 0.05
Sodium benzoate 0.2
Xylitol 0.1
l-Menthol 0.02
Dipotassium glycyrrhizinate 0.2
Ethanol 20.0
Carrageenan 0.1
Citric acid 0.1
Sodium citrate 0.05
Purified water balance
(Total 100% by mass)

[Formulation Example 4]
A liquid dentifrice was produced by a conventional method according to the following formulation (unit: mass%).
Condensed phosphate 0.5
(Product name: Taihei Chemical Industry Co., Ltd .: sodium metaphosphate (average degree of polymerization of phosphate residues: 30))
Mastic essential oil 0.05
Dipotassium glycyrrhizinate 0.2
Concentrated glycerin 20.0
Ethanol 20.0
Cellulose gum 4.0
Carrageenan 0.1
Citric acid 0.1
Sodium citrate 0.03
Purified water balance
(Total 100% by mass)

[Formulation Example 5]
Milky lotion was produced by a conventional method according to the following formulation (unit: mass%).
Condensed phosphate 0.5
(Product name manufactured by Mitsima Chemical Co., Ltd .: sodium ultraphosphate (average degree of polymerization of phosphate residues: 15))
Mastic essential oil 0.05
Sodium hyaluronate 3.0
Squalane 2.0
1,2-hexanediol 1.5
Polyacrylamide 0.3
Hydrogenated polyisobutene 0.3
Mineral oil 0.3
Polysorbade 85 0.15
Dipotassium glycyrrhizinate 0.1
Caprylyl glycol 0.3
Orange oil 0.2
Patchouli oil 0.1
Water balance
(Total 100% by mass)

[Formulation Example 6]
A face cream was produced by a conventional method according to the following formulation (unit: mass%).
Condensed phosphate 0.5
(Product name: Taihei Chemical Industry Co., Ltd .: sodium metaphosphate (average degree of polymerization of phosphate residues: 30))
Mastic essential oil 0.05
Squalane 13.0
Glycerin 5.0
Cetearyl alcohol 4.0
Sodium hyaluronate 3.0
Raffinose 2.0
1,2-hexanediol 1.5
Cetearyl glucoside 1.0
Caprylyl glycol 0.5
(Hydroxyethyl acrylate / acryloyldimethyltaurine Na) copolymer
0.4
Allantoin 0.1
Polysorbate 60 0.6
Sorbitan isostearate 0.02
Orange oil 0.2
Patchouli oil 0.1
Water balance
(Total 100% by mass)

[Formulation Example 7]
A deodorant was produced by a conventional method according to the following formulation (unit: mass%).
Sodium lauryl sulfate 50.0
Cocoamide DEA 2.0
Butylene glycol 3.0
Mint type fragrance 0.5
Condensed phosphate 0.5
(Product name manufactured by Mitsima Chemical Co., Ltd .: sodium ultraphosphate (average degree of polymerization of phosphate residues: 15))
Mastic essential oil 0.5
Water balance
(Total 100% by mass)

[Formulation Example 8]
A laundry detergent was produced by a conventional method according to the following formulation (unit: mass%).
Condensed phosphate 1.0
(Product name: Taihei Chemical Industry Co., Ltd .: sodium metaphosphate (average degree of polymerization of phosphate residues: 30))
Mastic essential oil 0.3
Zeolite 50.0
Sodium polyacrylate 10.0
Sodium carbonate 20.0
Sodium sulfate 15.0
Water balance
(Total 100% by mass)

Claims (11)

  An anti-cariogenic agent characterized by containing a condensed phosphate and a mastic processed product as active ingredients.   The anti-cariogenic agent according to claim 1, wherein the processed mastic is a mastic essential oil.   The condensed phosphate is at least one selected from the group consisting of polyphosphate, metaphosphate and ultraphosphate, and the average degree of polymerization of phosphoric acid is in the range of 4 to 30 phosphate residues. The anti-cariogenic agent according to claim 1 or 2.   A preservative comprising a condensed phosphate and a mastic processed product as active ingredients.   The preservative according to claim 4, wherein the processed mastic product is a mastic essential oil.   The condensed phosphate is at least one selected from the group consisting of polyphosphate, metaphosphate and ultraphosphate, and the average degree of polymerization of phosphoric acid is in the range of 4 to 30 phosphate residues. The preservative according to claim 4 or 5.   The composition for oral cavity containing the anti-caries agent of any one of Claims 1-3.   The composition containing the preservative of any one of Claims 4-6.   The composition according to claim 8, which is an oral composition or a skin external preparation.   A bacteriostatic agent comprising a condensed phosphate and a mastic processed product as active ingredients.   A composition comprising the bacteriostatic agent according to claim 10.

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