JP2002241253A - Oral composition - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide an oral composition excellent in bactericidal and antibacterial activities in the oral cavity, having a low irritation and effective for prophylaxis and therapy of periodontal diseases. SOLUTION: This oral composition is characterized by comprising a deep water or a dried product of the deep water and a fungicide.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

TECHNICAL FIELD The present invention relates to an oral composition. Specifically, excellent sterilization and antimicrobial effect in the oral cavity, impoverished, relates to an effective oral composition for the prevention and treatment of periodontal disease.

[0002]

2. Description of the Related Art In general, it is known that dental caries and periodontal diseases involve gram-negative bacteria such as Streptococcus mutans and Porphyromonas gingivalis. Dental caries, Streptococcus mutans to form a plaque on the tooth surface, to decompose various sugars lactate,
Generates an organic acid such as citric acid, accumulate in plaque occurs in demineralized enamel. Also, you're anaerobic environment deposited plaque, fixing periodontal pathogens such as gram-negative bacteria, with the growth occurs periodontitis by toxins and pathogenic substances producing bacteria, eventually periodontal disease Become.

Therefore, as a prophylaxis and treatment of dental caries and periodontal diseases, bactericides such as chlorhexidine and cetylpyridinium chloride have conventionally been incorporated into oral compositions such as dentifrices and mouthwashes. These fungicides, have excellent bactericidal effect, there are problems such as causing irritation, their improvement has been desired. Recently, extracts of various plants have been used as fungicides.

On the other hand, deep water is used for cosmetics (JP-A-10-18).
No. 2346) and skin cosmetics (JP-A-10-182)
347) and an external preparation (JP-A-10-182412)
JP) and have been utilized as a bath agent (JP-A-10-182424), it is not known that deep water is very effective oral compositions.

[0005]

DISCLOSURE OF THE INVENTION An object of the present invention is to provide an oral composition which has an excellent bactericidal and antibacterial effect in the oral cavity, is less irritating, and is effective for the prevention and treatment of periodontal diseases.

[0006]

Means for Solving the Problems When deep water is combined with a bactericide, the action inherent to the bactericide can be fully exhibited.
The present inventors have found that the effect is improved and the stimulation in the oral cavity is reduced, and the present invention has been completed. That is, the present invention provides: 1. an oral composition characterized by containing deep water or a deep water dried product and a bactericide; The oral composition according to the above 1, wherein the fungicide is mastic.

[0007]

BEST MODE FOR CARRYING OUT THE INVENTION Deep water used in the present invention is also referred to as deep ocean water, which is formed by subsidence of surface seawater to form a layer, and is low-temperature, clean, nutrient-rich natural water. For example, the intake area is off Toyama prefecture, off Kochi prefecture,
Off Okinawa, off Kanagawa, off Shizuoka, off Hawaii, etc.
Intake depth is 200-2000m, preferably 300-
1500 m.

In addition, components other than the essential recalcification components such as calcium and phosphorus in the deep water may be removed by a treatment such as dialysis, and the remineralization essential components may be concentrated.

The deep-water dried product used in the present invention is:
It is also called deep water crystal, dried using deep water as raw material,
For example, it can be obtained by natural drying, hot air drying, vacuum drying, freeze drying and the like.

The content of deep water as a component of the present invention is not particularly limited. For example, 0.1 to 90% by mass of deep water offshore of Kanagawa Prefecture (manufactured by Taisei Corporation) is incorporated in the composition. Can be.

The content of the deep water dried product, which is a component of the present invention, is not particularly limited. For example, the deep water dried product obtained by drying the deep water is added to the composition in an amount of 0.001 to 50.
% By mass.

The fungicides used in the present invention include chlorhexidine, cetylpyridinium chloride, hinokitiol, triclosan, benzalkonium chloride, benzethonium chloride, mastic and the like which can be used in oral cosmetics. Alternatively, two or more kinds can be appropriately selected and blended.

Among these fungicides, particularly preferred is mastic. The mastic is a mastic tree (Pistacia Lentisc), an evergreen tree of the family Ursiaceae distributed from the Mediterranean coast to Morocco and the Canary region.
us L.), which collected the sap that damaged the bark and flowed out. The sap hardens over time. Since it has a bactericidal and antibacterial effects such as anti-Helicobacter pylori for a long time, it has been formulated such as food gums, and the like.

The content of the bactericide, which is a component of the present invention, is not particularly limited. For example, Gum Magic
Oil [product name, manufactured by Sun Aroma Co., Ltd.] can be incorporated in the composition in an amount of 0.001 to 20% by mass.

The oral composition of the present invention contains the deep water or the deep water dried product and the bactericide according to the purpose of use.
Other components usually used in oral cosmetics can be blended at ordinary doses within a range not to impair the effects of the present invention.

For example, an abrasive, a wetting agent, a surfactant, a thickener, a flavor, a sweetener, a coloring agent, a preservative, a pH adjuster, and various medicinal ingredients are used in a normal dose within a range not to impair the effects of the present invention. It is possible to mix with.

Examples of the abrasive include aluminum oxide, aluminum hydroxide, aluminum silicate, zirconium silicate, silicic anhydride, precipitated silica, silica gel, calcium carbonate, calcium pyrophosphate, calcium hydrogen phosphate, calcium phosphate, and tricalcium phosphate. , hydroxyapatite, fluorapatite, halogenated apatite, magnesium carbonate, magnesium phosphate, insoluble sodium metaphosphate, calcium insoluble metaphosphate, titanium oxide, zeolite, synthetic resin abrasives, and the like.

Examples of the wetting agent include glycerin, sorbitol, ethylene glycol, propylene glycol, 1,
Examples thereof include 3-butylene glycol, polyethylene glycol, polypropylene glycol, dipropylene glycol, maltitol, xylitol, and lactitol.

Examples of the surfactant include anionic surfactants, cationic surfactants, amphoteric surfactants, and nonionic surfactants. Specific examples thereof include alkyl sulfates, alkyl benzene sulfonates, and sucrose fatty acids. ester,
Lactose fatty acid ester, lactitol fatty acid ester, maltitol fatty acid ester, sodium lauryl sulfate, sodium lauroyl sarcosine, sodium α-olefin sulfonate, N-acyl glutamate, 2
-Alkyl-N-carboxy-N-hydroxyethylimidazolinium betaine, N-acyl taurate, alkylol amide, pluronic, polyoxyethylene hydrogenated castor oil, polyoxyethylene sorbitan fatty acid ester, polyglycerin fatty acid ester, sorbitan fatty acid ester And fatty acid esters.

Examples of the thickener include hydroxyethylcellulose, sodium carboxymethylcellulose, methylcellulose, carrageenan, carboxyvinyl polymers, sodium polyacrylate, alkali metal salts of alginates such as sodium alginate, gums such as xanthan gum, juran gum, tragacanth gum, karaya gum and arabia gum. , Polyvinyl alcohol, polyvinylpyrrolidone, silica gel, aluminum silica gel, veegum, laponite and the like.

As fragrances, menthol, orange oil,
Spearmint oil, peppermint oil, lemon oil, eucalyptus oil, peppermint oil, acacia oil, fennel oil, kuentou oil, colums oil, camphor oil, Nikkei oil, cinnamon oil, silica leaf oil, rose oil, sandalwood oil, butterfly oil, Herbs oil, banana oil, apple oil, methyl salicylate, carvone, terpenes such as anethole, limonene, and compounded flavors.

[0022] As a sweetener, saccharin, sodium saccharin, xylitol, stevioside, stevia extract, rebaudioside, para-methoxy cinnamic aldehyde, neo Hess Perry Jill dihydroxy chalcone, perillartine, thaumatin, Gurichiruchin, glycyrrhizin monoglucopyranoside side, Hell Nan dulcin , Trehalose, aspartame, sorbit and the like.

Examples of the coloring agent include legal dyes such as Blue No. 1 and Yellow No. 4, titanium dioxide, caramel and the like.

Examples of the preservative include sodium benzoate, paraoxybenzoic acid esters, alkyldiaminoethylglycine hydrochloride and the like.

As the pH adjuster, citric acid, phosphoric acid,
Organic acids such as malic acid and acetic acid and salts thereof, sodium carbonate, sodium hydrogen carbonate, potassium carbonate, potassium hydrogen carbonate, ammonium carbonate, ammonium hydrogen carbonate, potassium sodium carbonate, lithium carbonate, urea, amino acid oligomer, calcium chloride, nitric acid calcium,
Calcium sulfate, calcium glycerophosphate, inorganic calcium such as calcium hydroxide, calcium lactate, calcium acetate, calcium malonate, calcium citrate, calcium glyconate, calcium glycerate,
Calcium tartrate, and organic calcium such as calcium phytate acid.

The active ingredients include allantoin, tocopherol acetate, isopropylmethylphenol, glycyrrhetinic acid, dextranase, chlorophyll, sodium copper chlorophyll, flavonoids, tranexamic acid,
Mutanase, lysozyme, amylase, protease,
Lytic enzymes, superoxide dismutase, epsilon aminocaproic acid, aluminum allantoin, aluminum chlorohydroxy allantoin, dihydrocholestanol, glycyrrhizic acids, bisabolol, glycerophosphate, water-soluble inorganic phosphate compounds, sodium fluoride, sodium monofluorophosphate, hydrofluoric acid Fluoride such as tin fluoride, potassium fluoride, sodium fluoride silicate, aluminum fluoride, silver fluoride, hexylamine hydrofluoride, decanolamine hydrofluoride, octadecenylamine hydrofluoride, etc. salts, zinc citrate, zinc chloride, copper gluconate, chlorhexidine gluconate, copper chloride, polyphosphates, pyrophosphates, vitamins a, C, E, B _6, vitamins such as pantothenic acid, glycine, Li Down, amino acids histidine, sodium chloride, sodium bicarbonate, aluminum lactate, potassium nitrate, sarcosinate, polyphenol compounds such as catechin, crude drugs and the like.

In addition, ethanol, water, silicone substance, sugar alcohol, natural extract and the like can be appropriately blended.

The oral composition of the present invention is blended with the above-mentioned components according to a conventional method, and is used in the preparation of powder dentifrices, moisturizing dentifrices, toothpastes, liquid dentifrices, liquid dentifrices, mouthwashes, mouth fresheners and the like. It can be prepared in various dosage forms. For example, in the case of producing a toothpaste, it can be produced by kneading the above components with an appropriate amount of the oral composition of the present invention or a mixture of an appropriate amount of the oral composition of the present invention and water. The toothpaste thus obtained is
An aluminum tube, a laminated tube in which both surfaces of an aluminum foil are laminated with plastic or the like, a tubular container such as a plastic tube, or a predetermined container such as a bottle-shaped container can be used.

[0029]

EXAMPLES The following is a description of specifics of the present invention shows the formulation examples of oral compositions used in the present invention to Examples 1-2, the present invention is not intended to be limited to the following examples. The deep water used was deep sea water off Kanagawa Prefecture [manufactured by Taisei Corporation], and the mastic used was Gum Magic Oil [product name, manufactured by Sun Aroma Co., Ltd.].

"Example 1" Dentifrice A toothpaste was prepared as shown in Table 1 and manufactured according to a usual production method. Using these oral compositions, it was evaluated antimicrobial effect.

Table 1 Raw material components Example 1 Comparative example 1 Comparative example 2 Silicic anhydride 20.0% by mass 20.0% by mass 20.0% by mass sorbite 35.0 35.0 35.0 glycerin 10.0 10.0 10.0 Sodium lauryl sulfate 1.0 1.0 1.0 Xanthan gum 1.5 1.5 1.5 1.5 Deep water 30.0 ━ Mastic 1.0 １．０ 1.0 Perfume Appropriate amount Appropriate amount Appropriate amount Purified water remaining Amount Appropriate amount Total 100.0 100.0 100.0 Antibacterial effect Effective Invalid Somewhat effective

[Test method] A prescribed amount of bacteria is inoculated into a dentifrice. The dentifrice inoculated with the bacteria is stored at 25 ° C, diluted on the 28th day by the pour method, and cultured at 35 ° C for 2 days.
After the culture, the number of colonies that appeared was counted, and the residual ratio of the bacteria was measured to make a determination.

The development of "criteria" effective bacteria hardly recognized. Somewhat effective bacterial growth is somewhat recognized. Many inactive bacteria grow.

As shown in Table 1, the composition of the present invention is clearly superior to the comparative examples.

"Example 2" Mouthwash was formulated as shown in Table 2, and a mouthwash was manufactured according to a usual manufacturing method. Using these oral compositions, irritation was evaluated using 10 panelists.

Table 2 Raw material components Example 1 Comparative example 1 glycerin 5.0% by mass 5.0% by mass ethanol 3.0 3.0 Polyoxyethylene sorbitan monostearate 1.0 1.0 Deep water 10.0% Stick 1.0 1.0 Perfume Appropriate amount Appropriate amount Purified water Remaining remaining amount Total 100.0 100.0 Evaluation of irritation Little irritation felt 9 people 1 person Slightly stimulated 1 person 4 people Stimulated considerably 0 people 5 Man

As shown in Table 2, the composition of the present invention is clearly superior to the comparative examples.

[0036]

The oral composition characterized by containing the deep water or the deep water dried product and the bactericide according to the present invention is excellent in the bactericidal and antibacterial effect in the oral cavity, has little irritation, and is effective for periodontal disease. It can be prevented and treated.

Continued on front page F term (reference) 4C083 AA021 AB151 AB172 AC102 AC122 AC132 AC442 AC782 AD352 BB48 CC41 DD27 EE33 4C084 AA19 NA05 ZA672 ZB352 ZC752 4C087 AA01 BA01 MA16 NA14 ZA67

Claims (1)

[Claims] 1. An oral composition comprising deep water or a deep water dried product and a bactericide.