CN114795997A - NMN-containing amino acid toothpaste and preparation method thereof - Google Patents
NMN-containing amino acid toothpaste and preparation method thereof Download PDFInfo
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- CN114795997A CN114795997A CN202210604317.0A CN202210604317A CN114795997A CN 114795997 A CN114795997 A CN 114795997A CN 202210604317 A CN202210604317 A CN 202210604317A CN 114795997 A CN114795997 A CN 114795997A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/606—Nucleosides; Nucleotides; Nucleic acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/99—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from microorganisms other than algae or fungi, e.g. protozoa or bacteria
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/02—Local antiseptics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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Abstract
The invention discloses NMN-containing amino acid toothpaste and a preparation method thereof, and belongs to the field of oral care products. The amino acid toothpaste is prepared from the following components in percentage by mass: deionized water to 100%, foaming agent to 3-17%, abrasive agent to 10-40%, humectant to 10-45%, thickener to 0.1-10%, sweetener to 0.1-1%, antiseptic to appropriate amount, NMN to 0.5-2%, lactobacillus fermentation product to 0.5-6%, and cortex Magnolia officinalis extract to 0.01-0.3%. Compared with the traditional toothpaste using sodium lauryl sulfate (K12), the toothpaste disclosed by the invention is safer and milder by using the amino acid surfactant as a foaming agent. The toothpaste has an antibacterial effect on common oral pathogenic bacteria such as porphyromonas gingivalis and the like, is safer than the traditional bactericide, does not influence oral micro-ecological groups, effectively inhibits the proliferation of the pathogenic bacteria competitively, promotes the proliferation of beneficial bacteria, improves the oral health and is suitable for various groups.
Description
Technical Field
The invention belongs to the field of oral care products, and relates to an NMN-containing amino acid toothpaste and a preparation method thereof.
Technical Field
The occurrence of oral diseases is closely related to the adhesive colonization of oral pathogens and the formation of biofilms. The toothpaste is a daily use product, and common toothpaste has the effects of cleaning oral cavity, removing peculiar smell and the like, but the antibacterial effect is not obvious. In the prior art, antibacterial ingredients such as triclosan and phenoxyethanol are added into toothpaste for bacteriostasis, so that a certain antibacterial effect can be achieved, but the toothpaste has unsafe risk, and oral micro-ecological groups are easy to generate dependence and drug resistance on the existing antibacterial ingredients, and are not beneficial to preventing and treating oral diseases.
In the aspect of a surfactant for toothpaste, the products in the market are mainly traditional sodium lauryl sulfate (K12), have relatively large irritation, are not friendly to oral mucosa and are easy to cause a plurality of oral problems. Sodium lauroyl sarcosinate, an amino acid surfactant, has the characteristics of mildness, low stimulation and certain foaming function, can well reflect the taste of essence, has certain cationic property due to the existence of amino, and has certain antibacterial effect when used in toothpaste.
NMN, all known as β -nicotinamide mononucleotide, is a precursor for the synthesis of the life factor NAD +. NAD + molecules are important supports for cell viability, improve the immune function of the organism, repair damaged cells, and can be used in toothpaste to improve the defense function of the oral cavity and reduce oral problems such as periodontitis. Gingivitis, plaque, etc.
Disclosure of Invention
In order to solve the problems in the prior art, the invention provides the NMN-containing amino acid toothpaste, which has good bacteriostatic action on common oral pathogenic bacteria such as porphyromonas gingivalis and the like by using sodium lauroyl sarcosine as a foaming agent and simultaneously adding NMN, a lactobacillus fermentation product and a magnolia bark extract, has no influence on oral micro-ecological groups and does not cause the bacterial groups to generate drug resistance, and is beneficial to the health of the oral cavity after long-term use.
The invention is realized by adopting the following technical scheme:
the NMN-containing amino acid toothpaste is prepared from the following components in percentage by mass:
deionized water to 100%, foaming agent 2-10%, abrasive 10-40%, humectant 10-45%, thickener 0.1-10%, sweetener 0.1-1%, antiseptic appropriate amount, NMN 0.5-2%, lactobacillus fermentation product 0.5-6%, and cortex Magnolia officinalis extract 0.01-0.3%.
Further, the NMN-containing amino acid toothpaste is prepared from the following components in percentage by mass:
deionized water to 100%, foaming agent 3-8%, abrasive 15-38%, humectant 15-40%, thickener 0.5-8%, sweetener 0.2-0.8%, antiseptic appropriate amount, NMN 0.7-1.8%, lactobacillus fermentation product 1-5%, and cortex Magnolia officinalis extract 0.02-0.15%.
Further, the NMN-containing amino acid toothpaste is prepared from the following components in percentage by mass:
deionized water to 100%, foaming agent 3.5-7%, abrasive 20-35%, humectant 18-35%, thickener 1-7%, sweetener 0.2-0.5%, antiseptic appropriate amount, NMN 0.8-1.5%, lactobacillus fermentation product 2-4%, and cortex Magnolia officinalis extract 0.04-0.12%.
Further, the amino acid toothpaste contains NMN, and the foaming agent is sodium lauroyl sarcosine.
Further, the NMN-containing amino acid toothpaste contains the abrasive which is one or more of hydrated silica, calcium carbonate, calcium hydrophosphate, pearl powder and aluminum hydroxide.
Further, the NMN-containing amino acid toothpaste comprises one or more of glycerin, sorbitol, propylene glycol and polyethylene glycol-8 as humectant.
Further, the NMN-containing amino acid toothpaste comprises one or more of xanthan gum, hydroxyethyl cellulose, sodium alginate, carrageenan and magnesium aluminum silicate as a thickening agent.
Further, the NMN-containing amino acid toothpaste comprises a sweetening agent which is one of saccharin sodium, aspartame and sucralose.
Further, the NMN-containing amino acid toothpaste is characterized in that the preservative is a compound of p-hydroxyacetophenone and 1, 2-hexanediol to replace the traditional preservative.
Further, the NMN-containing amino acid toothpaste comprises the active ingredients magnolol and magnolone in the cortex magnoliae officinalis bark extract in a mass ratio of 1:1, and the total content of magnolol and magnolone accounts for more than 98% of the mass of the cortex magnoliae officinalis bark extract.
The invention also provides a preparation method of the NMN-containing amino acid toothpaste, which comprises the following steps:
(1) mixing partial humectant with cortex Magnolia officinalis extract, and heating to dissolve completely
(2) Mixing hydroxyacetophenone and 1, 2-hexanediol, heating to dissolve completely, and keeping
(3) Putting deionized water, sweetener, NMN, mixture of partial humectant and cortex Magnolia officinalis extract, lactobacillus fermentation product, mixture of hydroxyacetophenone and 1, 2-hexanediol into a reaction kettle, and stirring
(4) Uniformly mixing the friction agent, the rest humectant and the thickening agent, slowly adding into a reaction kettle, stirring and mixing to obtain uniform paste
(5) Slowly adding foaming agent, stirring and mixing to obtain uniform paste
(6) Defoaming and discharging
Specific example 1-3 an NMN-containing amino acid toothpaste
The technical solutions of the present invention are further illustrated by the following specific examples, which do not represent limitations to the scope of the present invention. Insubstantial modifications and adaptations of the present invention by others of the concepts fall within the scope of the invention.
TABLE 1 formula of NMN-containing amino acid toothpaste
The preparation method comprises the following steps:
(1) mixing the A phase materials, heating to dissolve completely, and keeping
(2) Mixing the phase B materials, heating to dissolve completely, and keeping
(3) Adding the C-phase material into the reaction kettle, stirring uniformly, sequentially adding A, B-phase materials, and stirring uniformly
(4) Uniformly mixing the D-phase material, slowly adding the D-phase material into a reaction kettle, and stirring and mixing the D-phase material and the reaction kettle to obtain uniform paste
(5) Slowly adding phase E, stirring and mixing to obtain uniform paste
(6) Defoaming and discharging
Comparative example 1
Compared with example 1, except that sodium lauroyl sarcosinate is used instead of sodium lauryl sulfate, the conditions are the same as example 1.
Comparative example 2
The same conditions as in example 1 were used except that the bark extract of Magnolia officinalis was 0.005%, the fermentation product of Lactobacillus was 7%, and beta-nicotinamide mononucleotide was 3%, as compared with example 1.
Comparative example 3
The same conditions as in example 1 were used except that the bark extract of Magnolia officinalis was 0.3%, the fermentation product of Lactobacillus was 0.2%, and beta-nicotinamide mononucleotide was 3%, as compared with example 1.
Comparative example 4
The same conditions as in example 1 were used except that the content of Magnolia bark extract was 0.3%, the content of Lactobacillus fermentation product was 7%, and the content of beta-nicotinamide mononucleotide was 0.2%, as compared with example 1.
Comparative example 5
The same conditions as in example 1 were used except that the cortex Magnolia officinalis extract was 0.3% as compared with example 1.
Comparative example 6
The same conditions as in example 1 were used except that the cortex Magnolia officinalis extract was 0.005% as compared with example 1.
Comparative example 7
The conditions were the same as in example 1 except that the fermentation product of lactobacillus was 0.3% as compared with example 1.
Comparative example 8
The conditions were the same as in example 1 except that the fermentation product of Lactobacillus was 7% as compared with example 1.
Comparative example 9
Compared to example 1, except that beta-nicotinamide mononucleotide 0.2%, other conditions were the same as example 1.
Comparative example 10
Compared to example 1, except that beta-nicotinamide mononucleotide 3%, the other conditions were the same as example 1.
Comparative example 11
The same procedure as in example 1 was repeated except that only the bark extract of Magnolia officinalis was added, as compared with example 1.
Comparative example 12
The conditions were the same as in example 1 except that only the lactic acid bacteria fermentation product was added, as compared with example 1.
Comparative example 13
Compared to example 1, except that only beta-nicotinamide mononucleotide was added, the conditions were the same as example 1.
Comparative example 14
The procedure of example 1 was followed except that cortex Magnolia officinalis extract, Lactobacillus fermentation product, and beta-nicotinamide mononucleotide were removed, and 0.2% triclosan was added, as compared with example 1.
Experiment 1 bacteriostatic test for pathogenic bacteria
The toothpaste prepared in examples 1-3 and comparative examples 1-13 were tested for antibacterial and bacteriostatic effects on escherichia coli, staphylococcus aureus, porphyromonas gingivalis, streptococcus mutans, candida albicans, and helicobacter pylori according to QB/T2738-. Helicobacter pylori is a suspected pathogenic bacterium of halitosis, escherichia coli and staphylococcus aureus are suspected pathogenic bacteria related to pyogenic inflammation, porphyromonas gingivalis is a suspected pathogenic bacterium of periodontal inflammation and halitosis, streptococcus mutans is a pathogenic bacterium related to dental caries, and candida albicans is a suspected pathogenic fungus of dental ulcer.
TABLE 2 results of the bacteriostatic properties experiment
Wherein A represents Escherichia coli, B represents Staphylococcus aureus, C represents Porphyromonas gingivalis, D represents Streptococcus mutans, E represents Candida albicans, and F represents helicobacter pylori.
As can be seen from the results of the bacteriostasis experiments, the antibacterial and bacteriostatic effects of the samples of examples 1-3 on Escherichia coli, Staphylococcus aureus, Porphyromonas gingivalis, Streptococcus mutans, Candida albicans and helicobacter pylori are far higher than those of the samples of comparative examples 1-13. Compared with the comparative example 1, the sodium lauroyl sarcosinate serving as the foaming agent has better bacteriostatic effect than the sodium lauryl sulfate (K12) serving as the traditional foaming agent. Compared with the comparative examples 2-13, the NMN, the cortex magnoliae officinalis extract and the lactobacillus fermentation product supplement each other within a certain range, have synergistic effect, and can not achieve good antibacterial effect if the NMN, the cortex magnoliae officinalis extract and the lactobacillus fermentation product exceed or lack the range of the invention.
Experiment 2 competitive experiment
Streptococcus is one of the resident genus of the oral cavity, of which streptococcus salivarius is a recognized beneficial bacterium, and the quantity of streptococcus salivarius is small in people with oral problems compared with healthy people. Examples 1-3 and comparative example 14 were subjected to competitive experiments with Streptococcus salivarius, Porphyromonas gingivalis. The number of each bacterial species in the culture broth before and after the culture was measured by the dilution plate method, and the measurement results are shown in Table 3.
TABLE 3 results of competitive experiments
As can be seen from the results of the competitive experiments. Examples 1 to 3 were effective in competitively inhibiting the proliferation of Porphyromonas gingivalis and promoting the proliferation of the beneficial bacterium Streptococcus salivarius, and comparative example 14 inhibited not only the proliferation of Porphyromonas gingivalis but also the proliferation of the beneficial bacterium Streptococcus salivarius, and impaired the balance of oral microflora. The amino acid toothpaste containing the NMN can effectively regulate oral microbial flora, inhibit the proliferation of pathogenic bacteria and promote the proliferation of beneficial bacteria.
In conclusion, the amino acid surfactant is used as the foaming agent, so that the toothpaste is safer and milder compared with the traditional toothpaste using sodium lauryl sulfate (K12). Meanwhile, the toothpaste disclosed by the invention is added with the NMN, the lactobacillus fermentation product and the magnolia bark extract, the components supplement each other, the synergistic effect is realized, the antibacterial effect is realized on common oral pathogenic bacteria such as porphyromonas gingivalis and the like, the toothpaste is safer for a human body compared with the traditional bactericide triclosan and the like, the oral micro-ecological group is not influenced, the multiplication of the pathogenic bacteria is effectively competitively inhibited, and the multiplication of beneficial bacteria is promoted. The NMN-containing amino acid toothpaste provided by the invention has the effects of mildly and efficiently cleaning and improving oral health, and is suitable for various crowds.
In view of the many possible embodiments to which the principles of the disclosed invention may be applied, it should be recognized that the illustrated embodiments are only preferred examples of the application and should not be taken as limiting the scope of the application. Rather, the scope of the application is defined by the appended claims. We therefore claim as our invention all that comes within the scope and spirit of these claims.
Claims (11)
1. The NMN-containing amino acid toothpaste is characterized by being prepared from the following components in percentage by mass:
deionized water to 100%, foaming agent 2-10%, abrasive 10-40%, humectant 10-45%, thickener 0.1-10%, sweetener 0.1-1%, antiseptic appropriate amount, NMN 0.5-2%, lactobacillus fermentation product 0.5-6%, and cortex Magnolia officinalis extract 0.01-0.3%.
2. The NMN-containing amino acid toothpaste is characterized by being prepared from the following components in percentage by mass:
deionized water to 100%, foaming agent 3-8%, abrasive 15-38%, humectant 15-40%, thickener 0.5-8%, sweetener 0.2-0.8%, antiseptic appropriate amount, NMN 0.7-1.8%, lactobacillus fermentation product 1-5%, and cortex Magnolia officinalis extract 0.02-0.15%.
3. The NMN-containing amino acid toothpaste is characterized by being prepared from the following components in percentage by mass:
deionized water to 100%, foaming agent 3.5-7%, abrasive 20-35%, humectant 18-35%, thickener 1-7%, sweetener 0.2-0.5%, antiseptic appropriate amount, NMN 0.8-1.5%, lactobacillus fermentation product 2-4%, and cortex Magnolia officinalis extract 0.04-0.12%.
4. An NMN-containing amino acid toothpaste according to claims 1-3, characterized in that the foaming agent is sodium lauroyl sarcosinate.
5. An NMN-containing amino acid toothpaste as claimed in claims 1-3, wherein the abrasive is one or more of hydrated silica, calcium carbonate, calcium hydrogen phosphate, pearl powder, aluminium hydroxide.
6. An NMN-containing amino acid toothpaste according to claims 1-3, characterized in that the humectant is one or more of glycerol, sorbitol, propylene glycol, polyethylene glycol-8.
7. An NMN-containing amino acid toothpaste according to claims 1-3, characterized in that the thickener is one or more of xanthan gum, hydroxyethyl cellulose, sodium alginate, carrageenan, magnesium aluminium silicate.
8. An NMN-containing amino acid toothpaste according to claims 1-3, characterized in that the sweetener is one of saccharin sodium, aspartame, sucralose.
9. An NMN-containing amino acid toothpaste according to claims 1-3, characterized in that the preservative is a combination of p-hydroxyacetophenone and 1, 2-hexanediol instead of the traditional preservative.
10. The NMN-containing amino acid toothpaste as claimed in claims 1-3, wherein the weight ratio of magnolol to magnolone as active ingredients in the cortex Magnolia officinalis extract is 1:1, and the total content of magnolol and magnolone accounts for more than 98% of the cortex Magnolia officinalis extract.
11. A method of making an NMN-containing amino acid toothpaste according to claims 1-3, comprising the steps of:
(1) mixing partial humectant with cortex Magnolia officinalis extract, and heating to dissolve completely
(2) Mixing hydroxyacetophenone and 1, 2-hexanediol, heating to dissolve completely, and keeping
(3) Putting deionized water, sweetener, NMN, mixture of partial humectant and cortex Magnolia officinalis extract, and mixture of hydroxyacetophenone and 1, 2-hexanediol into a reaction kettle, and stirring
(4) Uniformly mixing the friction agent, the rest humectant and the thickening agent, slowly adding into a reaction kettle, stirring and mixing to obtain uniform paste
(5) Slowly adding foaming agent, stirring and mixing to obtain uniform paste
(6) Defoaming and discharging.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115300414A (en) * | 2022-09-02 | 2022-11-08 | 广东博然堂生物科技有限公司 | Mouthwash without surfactant and preparation method thereof |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2004250374A (en) * | 2003-02-20 | 2004-09-09 | Nippon Zettoc Co Ltd | Composition for oral cavity |
| US20070134171A1 (en) * | 2005-12-02 | 2007-06-14 | Dodds Michael W | Vehicles for oral care with magnolia bark extract |
| WO2014196947A1 (en) * | 2013-06-07 | 2014-12-11 | Pravdin Valeriy Valentinovch | Multifunctional toothpaste |
| CN106924120A (en) * | 2017-04-25 | 2017-07-07 | 上海中翊日化有限公司 | A kind of oral care substance of antibacterial, fresh breath |
| CN108653025A (en) * | 2018-06-04 | 2018-10-16 | 苏州欧丽特生物医药有限公司 | A kind of amino acid toothpaste and preparation method thereof |
| CN114191329A (en) * | 2021-12-17 | 2022-03-18 | 百瑞全球有限公司 | Oral care additive, oral care composition, preparation method, kit and application thereof |
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Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2004250374A (en) * | 2003-02-20 | 2004-09-09 | Nippon Zettoc Co Ltd | Composition for oral cavity |
| US20070134171A1 (en) * | 2005-12-02 | 2007-06-14 | Dodds Michael W | Vehicles for oral care with magnolia bark extract |
| WO2014196947A1 (en) * | 2013-06-07 | 2014-12-11 | Pravdin Valeriy Valentinovch | Multifunctional toothpaste |
| CN106924120A (en) * | 2017-04-25 | 2017-07-07 | 上海中翊日化有限公司 | A kind of oral care substance of antibacterial, fresh breath |
| CN108653025A (en) * | 2018-06-04 | 2018-10-16 | 苏州欧丽特生物医药有限公司 | A kind of amino acid toothpaste and preparation method thereof |
| CN114191329A (en) * | 2021-12-17 | 2022-03-18 | 百瑞全球有限公司 | Oral care additive, oral care composition, preparation method, kit and application thereof |
Non-Patent Citations (2)
| Title |
|---|
| Ö.E. GÜNGÖR: "《Who will win the race in childrens\' oral cavities? Streptococcus mutans or beneficial lactic acid bacteria?》", 《BENEFICIAL MICROBES》, vol. 4, no. 3, pages 237 - 245 * |
| 张明发: "《抗感染药学》", 《厚朴及其有效成分厚朴酚与和厚朴酚对 口腔感染性疾病防治作用的研究进展》, vol. 19, no. 4, pages 461 - 466 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115300414A (en) * | 2022-09-02 | 2022-11-08 | 广东博然堂生物科技有限公司 | Mouthwash without surfactant and preparation method thereof |
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