CN106562923B - Oral care composition containing profitable probliotics and its application in toothpaste - Google Patents
Oral care composition containing profitable probliotics and its application in toothpaste Download PDFInfo
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- CN106562923B CN106562923B CN201610662975.XA CN201610662975A CN106562923B CN 106562923 B CN106562923 B CN 106562923B CN 201610662975 A CN201610662975 A CN 201610662975A CN 106562923 B CN106562923 B CN 106562923B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/99—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from microorganisms other than algae or fungi, e.g. protozoa or bacteria
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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- Life Sciences & Earth Sciences (AREA)
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- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Cosmetics (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
The invention discloses the oral care composition containing profitable probliotics and its applications in toothpaste.The oral care composition is obtained according to the following steps by lactic acid bacteria, oligosaccharide, sapn: (1) being dissolved in sapn in 30~40 DEG C of water；(2) lactic acid bacteria is added, stirs 15~20 minutes, obtains mixed solution, -10 DEG C~-30 DEG C freeze-dryings；(3) oligosaccharide is uniformly mixed with freeze-dried powder obtained to get.The oral care product of oral care composition of the addition containing profitable probliotics has the effect of inhibiting plaque generation, resist gingivitis, going halitosis, safeguard oral health.
Description
Technical field
The present invention relates to oral care compositions, in particular to the oral care composition containing profitable probliotics and its in toothpaste
In application.
Background technique
Oral cavity is the important component of human body, is the origin or beginning of digestive system, mainly by lip, cheek, tongue, palate, salivary gland, tooth and
Jawbone etc. is formed, and is had the function of to chew, be swallowed, speech and feeling etc., and maintain the normal morphology of Maxillary region.Several factors
It may interfere with oral health, interfere it to exercise normal function, so that the appearance image of people and social interaction is affected, in addition, oral cavity
Disease can also directly or indirectly influence whole body health, influence quality of life.
Oral health is the basis of whole body health, the important component of whole body health, the direct or indirect shadow of oral health
Ring whole body health.Mouth disease such as dental caries, periodontal disease can destroy supporting tissue around hard tooth tissue and tooth, except influence
Outside the functions such as chewing, speech, beauty, it can also cause social interaction difficult and mental handicape.Some microorganism long-term existence are in mouth
In chamber, can lead to or aggravate certain general diseases such as coronary heart disease, diabetes etc., whole body health is endangered, quality of life is influenced.
National Oral Health Epidemiology investigation display, dental caries (being commonly called as decayed tooth or decayed tooth) and periodontal disease (including gum
Scorching and periodontitis) it is two kinds of most common diseases for endangering China's resident's oral health.
Saprodontia is gradually to be generated due to certain bacteriums in oral cavity using the sugared fermentation and acid in food.Periodontal disease
Disease is that the various diseases of supporting tissue's (cementum, alveolar bone, gum, parodontium) around tooth occur.It is that gum is red first
It is easy bleeding when swelling, touching, if cannot treat in time, it may appear that gingival atrophy, absorption of alveolar bone, periodontal bag formation, tooth
Loose compact and displacement, can also cause periodontal pyorrhea, oral peculiar smell sometimes, finally make loss of tooth or pull out.So periodontal disease
It is the main reason for causing adult's loss of tooth.
Above-mentioned two big mouth disease is mainly as caused by plaque.Therefore, pass through self oral health and professional oral cavity
It is the basis for safeguarding oral health that plaque is removed in health care.
Currently, for inhibit the active constituent of oral bacteria mainly have triclosan, zinc citrate, Cetylpyridinium Chloride etc. chemistry at
Point and the plant extracts such as polyphenol, flavones, alkaloid, plant glycosides.But as the chemical components such as triclosan, zinc citrate make
With some side effects can be generated in the process, the health of human body is influenced.And plant extracts etc. due to its activity it is weaker, for up to
It to corresponding effect, needs to increase the additive amount of plant extracts, so as to cause the appearance and mouthfeel for affecting product, gives people
Certain pain is caused in use process.
Probiotics can generate some metabolites in process of production, such as organic acid, hydrogen peroxide, ablastins, anti-attachment
The ingredients such as agent, cohesion molecule, have antimicrobial effect.Some special probiotics, which have been shown to have, inhibits oral cavity harmful thin
The effect of bacterium growth.
Patent publication No. CN 101190239A discloses a kind of product containing LP lactic acid bacteria, to inhibit bacterium to cause
Odontopathy, this product include multiple LP lactic acid bacterias, odontopathy bacterial growth can be inhibited.
Patent application publication CN 102470151A provides that a kind of pair of disease in mouth reason bacterium spectrum is wide, can manufacture wind
The novel lactic bacterial strain for the fermentation material that taste is good, hobby property is excellent, and the prevention of the disease in mouth with the phase made of, improvement or
Person's therapeutic agent.
Patent application publication CN 103119153A discloses a kind of bacterium bacterial strain, it is characterised in that they present and are directed to
The inhibitory activity of raw dental caries biology.Also disclose drug and/or probiotics/prebiotic promotor composition, function etc. can be used for treat and/
Or at least one bacterial strain described in the present invention and/or at least one biologically active peptide of prevention oral infections disease, preferably saprodontia
Or combinations thereof.
Patent application publication CN103298924A is provided comprising a effective amount of plant lactobacillus CECT7481 and short cream
The composition of bacillus CECT7480 has the application in terms of improving oral health.
Patent application publication CN104140937A provides a kind of lactobacillus plantarum KLDS1001, to oral cavity variation hammer
Bacterium is inhibited, can be used as a kind of adding ingredient of oral health-care product, is used for oral health.
Patent application publication CN 103384526A is related to especially being used for as sensuously neutral oral cavity nursing agent
Pre- dental calculus preventing, microorganism or its segment for anti-caries agent and/or anti-oral malodor agent.
Patent application publication CN105434322A discloses a kind of toothpaste containing oral cavity probiotics, and clinical test shows
The toothpaste has good curative effect to gingivitis, periodontitis, halitosis.
Patent application publication CN105534875A discloses a kind of antibacterial antiallergic perception compositions for oral-cavity article, packet
Containing anti-sensitive agent and probiotics.The composition can help user to solve bleeding gums, halitosis, tooth mobility, sensitivity of tooth
Etc. symptoms.
Probiotics, as a kind of biological antibiosis agent, the relatively chemical antibacterial agent of bacteriostatic activity is weaker, to ensure that product has
Good effect generally requires the additive amount for increasing probiotics in formula, this can cause certain shadow for the stability of formula
It rings, while greatly improving formulation cost, be unfavorable for the marketing of product.
On the other hand, the ionic surfactant in oral care implement, essence, preservative can kill probiotics, lead
Causing the antibacterial effect of probiotics reduces, to influence final effect of product.
Summary of the invention
Based on this, the present invention provides a kind of oral care composition containing profitable probliotics by a large amount of scientific research
And its application in toothpaste.Inventors be surprised to learn that oligosaccharide has facilitation to the fungistatic effect of lactic acid bacteria, cream is improved
The growth inhibitory effect to pathogenic bacteria of sour bacterium reduces the additive amount of lactic acid bacteria in formula；On the other hand, sapn is as a kind of
Stabilizer can be improved the stability of lactic acid bacteria in formula, further improve the bacteriostasis property of lactic acid bacteria.By adding this
Three's composition has final oral care product and inhibits plaque generation, resist gingivitis, goes halitosis, and maintenance oral cavity is strong
The effect of health.
The object of the invention is achieved through the following technical solutions:
Oral care composition containing profitable probliotics, the composition press following weight percent by lactic acid bacteria, oligosaccharide, sapn
Than composition:
Lactic acid bacteria 20~60%
Oligosaccharide 20~60%
Sapn 10~30%；
Summation is 100%.
The composition is to obtain according to the following steps: (1) being dissolved in sapn in 30~40 DEG C of water；(2) lactic acid bacteria is added,
Stirring 15~20 minutes；By above-mentioned mixed solution, -10 DEG C~-30 DEG C freeze-dryings；(3) oligosaccharide and freeze-dried powder obtained are mixed
Close uniformly to get.
In order to improve the bacteriostatic activity of lactic acid bacteria, order by merging of the invention is unable to adjust, especially by mixed solution
Oligosaccharide could be added after freeze-drying.
Wherein, the lactic acid bacteria is one or more of lactobacillus paracasei, Bifidobacterium, saliva Bacillus acidi lactici；
The oligosaccharide is malto-oligosaccharide glucose, isomalto-oligosaccharide glucose, coupling sugar glucose, panose grape
One or more of sugar.
The sapn is one or more of Arlacel-20, Arlacel-80.
In addition, the present invention provides the answering in oral care implement of the oral care composition containing profitable probliotics
With.The oral care implement includes but is not limited to toothpaste, mouthwash, tooth powder, false-tooth cleaning plate, mouth spray, chewing gum, tooth patch
Deng.
The present invention also provides application of the oral care composition containing profitable probliotics in toothpaste, the weights of each ingredient
It is as follows to measure percentage composition:
The moisturizer is one or more of sorbierite, glycerol, antierythrite.
The rubbing agent is one or more of silica, calcium phosphate dibasic dihydrate, calcium carbonate.
The thickener is one or more of sodium carboxymethylcellulose, xanthan gum, aluminum magnesium silicate, carrageenan.
The sweetener is one or more of xylitol, tri-chloro galactose type sugar, steviol glycoside, acesulfame potassium.
The stabilizer is one or more of tetrasodium pyrophosphate, tetrapotassium pyrophosphate.The pH value for adjusting lotion, prevents lotion
Divide oil, water outlet.
The natural essence is one or more of peppermint, sweet orange, strawberry, apple；
The surfactant is natural soap tree extractive, laruyl alcohol sodium sarcosinate, one in sodium cocoyl glutamate
Kind or more.
The present invention compared with the existing technology possessed by advantage and the utility model has the advantages that
(1) oligosaccharide in the oral care composition of the invention containing profitable probliotics has promotion to the fungistatic effect of lactic acid bacteria
The growth inhibitory effect to pathogenic bacteria of lactic acid bacteria has can be improved in effect, reduces the additive amount of lactic acid bacteria in formula.
(2) the step of preparation method of the present invention is immutable, and the oral care composition containing profitable probliotics has been made, and improves
The bacteriostatic activity of lactic acid bacteria, reduces its additive amount in toothpaste.
(3) sapn is added to as stabilizer in the oral care composition of the invention containing profitable probliotics, further increase
The bacteriostasis property of lactic acid bacteria.
Specific embodiment
In order to make the objectives, technical solutions, and advantages of the present invention clearer, with reference to embodiments, to the present invention
It is further elaborated.It should be appreciated that the specific embodiments described herein are merely illustrative of the present invention, it is not used to
Limit the present invention.
Embodiment 1-3:
Oral care composition containing profitable probliotics is by Bifidobacterium, malto-oligosaccharide glucose, Arlacel-20 by following heavy
Measure percentage composition.
The oral care composition is to obtain according to the following steps: (1) being dissolved in sapn in 40 DEG C of water；(2) cream is added
Sour bacterium stirs 20 minutes；By above-mentioned mixed solution, -10 DEG C of freeze-dryings；(3) oligosaccharide is uniformly mixed with freeze-dried powder obtained,
To obtain the final product.
It is investigated involved in the present invention for the antibacterial effect for verifying the above oral care composition using Cell suppression test
Composition to the growth inhibition effect of oral cavity pathogen.
By oral care composition obtained by above-described embodiment 1,2,3 and the oral cavity pathogen phase for being in logarithmic growth phase
After mutually mixing, using the growth curve of absorbance method measurement pathogenic bacteria, indicated with Δ OD.Δ OD nominal growth is slower, shows group
It is better to the growth inhibitory effect of pathogenic bacteria to close object.Control group in test is the pathogenic bacteria without adding composition.Experiment is used
Oral cavity pathogen is Streptococcus mutans, Fusobacterium nucleatum.Test result is as follows:
| 1h | 2h | 4h | 8h | 24h | |
| Embodiment 1 | 0.01 | 0.01 | 0.02 | 0.05 | 0.1 |
| Embodiment 2 | 0 | 0.01 | 0.03 | 0.06 | 0.12 |
| Embodiment 3 | 0.04 | 0.06 | 0.1 | 0.13 | 0.15 |
| Control | 0.1 | 0.2 | 0.22 | 0.24 | 0.3 |
Above-mentioned test result shows that composition according to the present invention is good and oligomeric to the growth result of oral cavity pathogen
Sugar has significant facilitation to the fungistatic effect of lactic acid bacteria, and oligosaccharide can promote the antibacterial effect of lactic acid bacteria.
Composition according to the present invention can be applied in oral care product, including but not limited to toothpaste, mouthwash, tooth
Powder, false-tooth cleaning plate, mouth spray, chewing gum, tooth patch etc..
Embodiment 4-6:
Oral care composition containing profitable probliotics is pressed by lactobacillus paracasei, isomalto-oligosaccharide glucose, Arlacel-80
Following weight percent composition.
The oral care composition is to obtain according to the following steps: (1) being dissolved in sapn in 30 DEG C of water；(2) cream is added
Sour bacterium stirs 15 minutes；By above-mentioned mixed solution, -30 DEG C of freeze-dryings；(3) oligosaccharide is uniformly mixed with freeze-dried powder obtained,
To obtain the final product.
It is investigated involved in the present invention for the antibacterial effect for verifying the above oral care composition using Cell suppression test
Composition to the growth inhibition effect of oral cavity pathogen.
By oral care composition obtained by above-described embodiment 4,5,6 and the oral cavity pathogen phase for being in logarithmic growth phase
After mutually mixing, using the growth curve of absorbance method measurement pathogenic bacteria, indicated with Δ OD.Δ OD nominal growth is slower, shows group
It is better to the growth inhibitory effect of pathogenic bacteria to close object.Control group in test is the pathogenic bacteria without adding composition.Experiment is used
Oral cavity pathogen is Streptococcus mutans, Fusobacterium nucleatum.Test result is as follows:
| 1h | 2h | 4h | 8h | 24h | |
| Embodiment 4 | 0.02 | 0.03 | 0.04 | 0.06 | 0.12 |
| Embodiment 5 | 0 | 0.01 | 0.02 | 0.04 | 0.08 |
| Embodiment 6 | 0.03 | 0.04 | 0.07 | 0.10 | 0.16 |
| Control | 0.1 | 0.2 | 0.22 | 0.24 | 0.3 |
Above-mentioned test result shows that composition according to the present invention is good to the growth result of oral cavity pathogen, and is added
Sapn is as the fungistatic effect that can significantly improve lactic acid bacteria after stabilizer.
Embodiment 7 changes the Contrast on effect experiment of the step of preparation method
Oral care composition containing profitable probliotics is pressed by lactobacillus paracasei, isomalto-oligosaccharide glucose, Arlacel-80
Following weight percent composition.
The oral care composition of embodiment 7 is to obtain according to the following steps: (1) being dissolved in sapn in 30 DEG C of water；(2) add
Enter lactic acid bacteria and oligosaccharide, stirs 15 minutes；By above-mentioned mixed solution, -30 DEG C are lyophilized to obtain the final product.
The oral care composition obtained with the method (the method for the present invention) of embodiment 4 compares, and experiment is caused with oral cavity
Germ is Streptococcus mutans, Fusobacterium nucleatum.Test result is as follows:
| 1h | 2h | 4h | 8h | 24h | |
| Embodiment 4 | 0.02 | 0.03 | 0.04 | 0.06 | 0.12 |
| Embodiment 7 | 0.06 | 0.07 | 0.09 | 0.14 | 0.3 |
Above-mentioned test result shows that oral cavity composition made from the method for the present invention is good to the growth result of oral cavity pathogen,
The step of changing preparation process will affect the fungistatic effect of lactic acid bacteria.
Embodiment 8-10
Toothpaste making process of the present invention is as follows:
1) rubbing agent, thickener are weighed up by formula, until being stirred evenly in powder material tank stand-by
2) by sweetener, stabilizer is mixed evenly for use in deionized water；
3) it by moisturizer, weighs up by formula and is mixed for use in liquid tank；
4) it by essence, is weighed up by formula, for use.
6) vacuum system for opening Manufacturing medicine extract machine, is evacuated to -0.6MPa for vacuum degree；The material for sucking step 2 and 3, is opened simultaneously
Vacuum degree is evacuated to -0.75MPa by dynamic blender, and pumping is stirred 10 minutes.
7) material in steps for importing 1, and keep vacuum degree in -0.4MPa into complete, is taken out until by the material in step 1
Vacuum stirs 15 minutes to maximum (- 0.10MPa).
8) add natural essence, surfactant, the oral care composition containing profitable probliotics respectively, stir 3 minutes；It takes out true
Sky to maximum (- 0.10MPa), stir 20 minutes to get.
The test of toothpaste antibacterial effect；
Using the method for minimal inhibitory concentration, embodiment 8, embodiment 9, the effect of the anti-cariogenic bacteria of 10 toothpaste of embodiment are evaluated
Fruit, test strain are streptococcus mutans and Bacillus acidi lactici.Both bacteriums are the most important pathogenic bacteria of saprodontia.
Test result is as follows:
From test result as can be seen that the toothpaste for being added to the oral care composition containing profitable probliotics has good resist
The effect of cariogenic bacteria, it is antibacterial after adding the oral care composition containing profitable probliotics compared with the product for being not added with composition
Effect is also improved.
The embodiments described above only express several embodiments of the present invention, should not be understood as to the invention patent range
Limitation.It should be pointed out that for those of ordinary skill in the art, without departing from the inventive concept of the premise,
Various modifications and improvements can be made, and these are all within the scope of protection of the present invention.Therefore, the scope of protection of the patent of the present invention
It should be determined by the appended claims.
Claims (9)
1. a kind of oral care composition containing profitable probliotics, which is characterized in that the oral care composition is by lactic acid bacteria, low
Glycan, sapn are formed by following weight percent:
Lactic acid bacteria 20~60%
Oligosaccharide 20~60%
Sapn 10~30%；
Summation is 100%；
The oral care composition is to obtain according to the following steps: (1) being dissolved in sapn in 30~40 DEG C of water；(2) cream is added
Sour bacterium stirs 15~20 minutes, obtains mixed solution, -10 DEG C~-30 DEG C freeze-dryings；(3) by oligosaccharide and freeze-dried powder obtained
Be uniformly mixed to get.
2. oral care composition according to claim 1, which is characterized in that the lactic acid bacteria be lactobacillus paracasei,
One or more of Bifidobacterium, saliva Bacillus acidi lactici.
3. oral care composition according to claim 1, which is characterized in that the oligosaccharide is malto-oligosaccharide grape
One or more of sugar, isomalto-oligosaccharide glucose, coupling sugar glucose, panose glucose.
4. oral care composition according to claim 1, which is characterized in that the sapn is Arlacel-20, Arlacel-80
One or more of.
5. application of the oral care composition described in claim 1 in oral care implement.
6. application of the oral care composition described in claim 1 in toothpaste, which is characterized in that each ingredient contains in toothpaste
Amount is as follows, by weight percentage:
7. application according to claim 6, which is characterized in that the moisturizer is sorbierite, in glycerol, antierythrite
More than one.
8. application according to claim 6, which is characterized in that the rubbing agent be silica, calcium phosphate dibasic dihydrate,
One or more of calcium carbonate.
9. application according to claim 6, which is characterized in that the surfactant is natural soap tree extractive, the moon
One or more of cinnamic alcohol sodium sarcosinate, sodium cocoyl glutamate.
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| CN110772475A (en) * | 2019-12-10 | 2020-02-11 | 广州瑞誉化工科技有限公司 | Probiotic toothpaste |
| TWI748395B (en) * | 2020-03-31 | 2021-12-01 | 豐華生物科技股份有限公司 | Composition for relieving allergies and improving exercise performance and uses thereof |
| CN111632021A (en) * | 2020-07-27 | 2020-09-08 | 浙江爱尚日用品有限公司 | Probiotics toothpaste for preventing gingival atrophy |
| CN112754987B (en) * | 2021-03-06 | 2022-03-25 | 江苏新申奥生物科技有限公司 | Oral care composition containing probiotics and application thereof |
| CN115006341B (en) * | 2022-07-21 | 2023-12-19 | 重庆登康口腔护理用品股份有限公司 | Oral cavity cleaning and nursing composition capable of regulating oral cavity microecological balance and preparation method thereof |
| CN115708799B (en) * | 2022-12-16 | 2024-03-12 | 广州悦创实业有限公司 | Mild caries-preventing children liquid toothpaste and preparation method thereof |
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| CN105434322A (en) * | 2015-12-22 | 2016-03-30 | 南昌理工学院 | Toothpaste containing oral cavity probiotics |
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| CN101002580B (en) * | 2007-01-04 | 2010-05-19 | 四川省食品发酵工业研究设计院 | Technique for preparing direct use agent with high activity for producing picled vegetables |
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| CN105434322A (en) * | 2015-12-22 | 2016-03-30 | 南昌理工学院 | Toothpaste containing oral cavity probiotics |
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