CN106562923A - Oral care composition containing probiotics, and application of oral care composition to toothpaste - Google Patents
Oral care composition containing probiotics, and application of oral care composition to toothpaste Download PDFInfo
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- CN106562923A CN106562923A CN201610662975.XA CN201610662975A CN106562923A CN 106562923 A CN106562923 A CN 106562923A CN 201610662975 A CN201610662975 A CN 201610662975A CN 106562923 A CN106562923 A CN 106562923A
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- oral care
- care composition
- lactic acid
- acid bacteria
- span
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/99—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from microorganisms other than algae or fungi, e.g. protozoa or bacteria
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Cosmetics (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
The invention discloses an oral care composition containing probiotics, and an application of the oral care composition to toothpaste. The oral care composition is prepared from lactic acid bacteria, polysaccharides and Span through the following steps of (1) dissolving the Span in water with the temperature of 30-40 DEG C; (2) adding the lactic acid bacteria, performing stirring for 15-20 minutes to obtain a mixed solution, and performing freeze-drying at -10 DEG C to -30 DEG C; and (3) uniformly mixing oligosaccharides with the obtained freeze-dried powder to obtain the oral care composition. An oral care product added with the oral care composition containing the probiotics has the effects of inhibiting dental plaque generation, resisting gingivitis, removing halitosis and maintaining oral health.
Description
Technical field
The present invention relates to oral care composition, the more particularly to oral care composition containing profitable probliotics and its in toothpaste
In application.
Background technology
Oral cavity is the important component part of human body, is the origin or beginning of digestive system, mainly by lip, cheek, tongue, palate, salivary gland, tooth and
Jawbone etc. is constituted, and with chewing, swallow, the function such as speech and sensation, and maintains the normal morphology of Maxillary region.Several factors
Oral health is may interfere with, hinders it to exercise normal function, the appearance image and social communication for making people is affected, additionally, oral cavity
Disease can also directly or indirectly affect whole body health, affect quality of life.
Oral health is the basis of whole body health, the important component part of whole body health, the direct or indirect shadow of oral health
Ring whole body health.Oral disease such as dental caries, periodontal can destroy supporting tissue around hard tooth tissue and tooth, except impact
Outside the function such as chewing, speech, attractive in appearance, can also cause social communication difficult and mental maladjustment.Some microorganism long-term existence are in mouth
In chamber, can cause or aggravate some general diseases such as coronary heart disease, diabetes etc., endanger whole body health, affect quality of life.
National oral health epidemiological investigation shows that dental caries (being commonly called as dental caries or decayed tooth) and periodontal are (including gingiva
Scorching and periodontitis) it is two kinds of modal diseases for endangering China's resident's oral health.
Dental caries, be due to some antibacterials in oral cavity, using food in sugared fermentation and acid and gradually produce.Periodontal disease
Disease is the various diseases that the supporting tissue (cementum, alveolar bone, gingiva, periodontal membrane) around tooth occurs.First it is that gingiva is red
Easy bleeding when swelling, touching, if cannot treat in time, it may appear that gingival atrophy, frontal resorption, periodontal bag formation, tooth
Loose compact and displacement, can also cause periodontal pyorrhea, halitosiss sometimes, finally make loss of tooth or pull out.So periodontal
It is the main cause for causing adult's loss of tooth.
What above-mentioned two big oral disease was mainly caused by dental plaque.Therefore, by self oral cavity health and professional oral cavity
It is the basis for safeguarding oral health that dental plaque is removed in health care.
Be presently used for suppress oral cavity bacterium active component mainly have triclosan, zinc citrate, cetylpyridinium chloride etc. chemistry into
Point, and the plant extract such as polyphenol, flavone, alkaloid, plant glycosides.But as the chemical compositions such as triclosan, zinc citrate make
Some side effect can be produced with during, the healthy of human body is affected.And plant extract etc. is weaker due to its activity, be up to
To corresponding effect, the addition for increasing plant extract is needed, so as to cause to have impact on the outward appearance of product and mouthfeel, given people
Certain pain is caused during use.
Probiotic bacteria can produce in process of production some metabolites, such as organic acid, hydrogen peroxide, ablastins, anti-attachment
The compositions such as agent, cohesion molecule, with antimicrobial effect.It is harmful thin that some special probiotic bacterias have been shown to have suppression oral cavity
The effect of bacteria growing.
Patent publication No. CN 101190239A discloses a kind of product containing LP lactic acid bacterias, to suppress antibacterial to cause
Odontopathy, this product include multiple LP lactic acid bacterias, odontopathy bacterial growth can be suppressed.
Public announcement of a patent application CN 102470151A provide it is a kind of it is wide to disease in mouth reason bacterium spectrum, wind can be manufactured
The novel lactic bacterial strain of the fermented product that taste is good, hobby property is excellent, and the prevention with disease in mouth made by the phase, improve or
Person's therapeutic agent.
Public announcement of a patent application CN 103119153A disclose a kind of bacterial isolateses, it is characterised in that they present and are directed to
The biological inhibitory activity of raw dental caries.Also disclose medicine and/or probiotic bacteria/prebiotic promotor composition, function etc. can be used for treatment and/
Or prevention oral infections are sick, at least one bacterial strain described in the preferred dental caries present invention and/or at least one biologically active peptide
Or its combination.
Public announcement of a patent application CN103298924A provides the plant lactobacillus CECT7481 comprising effective dose and short breast
The compositionss of bacillus CECT7480, with the application improved in terms of oral health.
Public announcement of a patent application CN104140937A provides a kind of Lactobacillus plantarum KLDS1001, and make a variation hammer to oral cavity
Bacterium is inhibited, can be as a kind of adding ingredient of oral health-care product, for oral cavity health.
Public announcement of a patent application CN 103384526A are related to as sensuously neutral oral cavity nursing agent, are particularly used for
Pre- dental calculus preventing, for the microorganism or its fragment of anti-caries agent and/or anti-oral malodor agent.
Public announcement of a patent application CN105434322A discloses a kind of toothpaste containing oral cavity probiotic bacteria, and clinical trial shows
The toothpaste has good curative effect to gingivitiss, periodontitis, halitosis.
Public announcement of a patent application CN105534875A discloses a kind of antibacterial antiallergic perception compositions for oral-cavity article, bag
Containing anti-sensitive agent and probiotic bacteria.Said composition can help user to solve gingival hemorrhage, halitosis, odontoseisiies, sensitivity of tooth
Etc. symptom.
Probiotic bacteria, used as a kind of biological antibiosis agent, its bacteriostatic activity relative chemical antibacterial is weaker, to guarantee that product has
Good effect, generally requires the addition that probiotic bacteria is increased in formula, and this can be that the stability of formula causes certain shadow
Ring, while greatly improving formulation cost, be unfavorable for the marketing of product.
On the other hand, ionic surfactant in oral care implement, essence, preservative can kill probiotic bacteria, lead
Causing the antibacterial effect of probiotic bacteria reduces, so as to affect final effect of product.
The content of the invention
Based on this, the present invention is by substantial amounts of scientific research, there is provided a kind of oral care composition containing profitable probliotics
And its application in toothpaste.Inventors be surprised to learn that polysaccharide has facilitation to the fungistatic effect of lactic acid bacteria, improve breast
The growth inhibitory effect to pathogenic bacterium of sour bacterium, reduces addition of the lactic acid bacteria in formula；On the other hand, span is used as one kind
Stabilizer, can improve stability of the lactic acid bacteria in formula, further increase the bacteriostasis property of lactic acid bacteria.By adding this
Three's compositionss, have final oral care product and suppress dental plaque generation, resist gingivitis, go halitosis, safeguard that oral cavity is good for
Effect of health.
The object of the invention is achieved through the following technical solutions：
Oral care composition containing profitable probliotics, said composition presses following weight percent by lactic acid bacteria, oligosaccharide, span
Than composition：
Lactic acid bacteria 20～60%
Oligosaccharide 20～60%
Span 10～30%；
Summation is 100%.
The compositionss are to obtain according to the following steps：(1) span is dissolved in 30～40 DEG C of water；(2) lactic acid bacteria is added,
Stirring 15～20 minutes；By above-mentioned mixed solution, -10 DEG C～-30 DEG C lyophilizing；(3) oligosaccharide is mixed with the lyophilized powder for being obtained
Close uniform, obtain final product.
In order to improve the bacteriostatic activity of lactic acid bacteria, the order by merging of the present invention can not be adjusted, especially by mixed solution
Oligosaccharide could be added after lyophilizing.
Wherein, the lactic acid bacteria is one or more of Lactobacillus paracasei, bacillus bifiduss, saliva lactobacilluss；
The oligosaccharide is Fructus Hordei Germinatus oligose glucose, dextrinosan glucose, coupling sugar glucose, Pan pool Fructus Vitis viniferae
One or more of sugar.
The span is one or more of Arlacel-20, Arlacel-80.
In addition, the invention provides the oral care composition containing profitable probliotics answering in oral care implement
With.The oral care implement includes but is not limited to toothpaste, collutory, dentifrice, false-tooth cleaning plate, mouth spray, chewing gum, tooth patch
Deng.
Present invention also offers application of the oral care composition containing profitable probliotics in toothpaste, the weight of each composition
Amount percentage composition is as follows：
The wetting agent is one or more of Sorbitol, glycerol, erythritol.
Described abrasivuss are one or more of silicon dioxide, calcium phosphate dibasic dihydrate, Calcium Carbonate.
The thickening agent is one or more of sodium carboxymethyl cellulose, xanthan gum, Magnesiumaluminumsilicate, carrageenin.
The sweeting agent is one or more of xylitol, tri-chloro galactose type sugar, stevioside, acesulfame potassium.
The stabilizer is one or more of tetrasodium pyrophosphate, tetrapotassium pyrophosphate.The pH value of mastic is adjusted, mastic is prevented
Divide oil, water outlet.
The natural essence is one or more of Herba Menthae, Fructus Citri sinensiss, Fructus Fragariae Ananssae, Fructus Mali pumilae；
The surfactant is in natural soap tree extractive, lauryl alcohol sodium sarcosinate, sodium cocoyl glutamate
More than kind.
The present invention has the advantage that and beneficial effect relative to prior art：
(1) polysaccharide in oral care composition of the present invention containing profitable probliotics has promotion to the fungistatic effect of lactic acid bacteria
Effect, can improve the growth inhibitory effect to pathogenic bacterium of lactic acid bacteria, reduce addition of the lactic acid bacteria in formula.
(2) the step of preparation method of the present invention is immutable, and the oral care composition containing profitable probliotics has been obtained, and improves
The bacteriostatic activity of lactic acid bacteria, reduces its addition in toothpaste.
(3) span is with the addition of as stabilizer, further improve in oral care composition of the present invention containing profitable probliotics
The bacteriostasis property of lactic acid bacteria.
Specific embodiment
In order that the objects, technical solutions and advantages of the present invention become more apparent, with reference to embodiments, to the present invention
It is further elaborated.It should be appreciated that specific embodiment described herein is not used to only to explain the present invention
Limit the present invention.
Embodiment 1-3：
Oral care composition containing profitable probliotics is by bacillus bifiduss, Fructus Hordei Germinatus oligose glucose, Arlacel-20 by following heavy
Amount percentage ratio composition.
The oral care composition is to obtain according to the following steps：(1) span is dissolved in 40 DEG C of water；(2) breast is added
Sour bacterium, stirs 20 minutes；By above-mentioned mixed solution, -10 DEG C of lyophilizing；(3) oligosaccharide is mixed homogeneously with the lyophilized powder for being obtained,
Obtain final product.
To verify the antibacterial effect of above oral care composition, using Cell suppression test, investigate involved in the present invention
Growth inhibition effect of the compositionss to oral cavity pathogen.
By the oral care composition obtained by above-described embodiment 1,2,3 and the oral cavity pathogen phase in exponential phase
After mutually mixing, the growth curve of pathogenic bacterium is determined using absorbance method, represented with Δ OD.Δ OD nominal growths are slower, show group
Compound is better to the growth inhibitory effect of pathogenic bacterium.Matched group in test is the pathogenic bacterium for not adding compositionss.Experiment is used
Oral cavity pathogen is Streptococcus mutans, Fusobacterium nucleatum.Test result is as follows：
| 1h | 2h | 4h | 8h | 24h | |
| Embodiment 1 | 0.01 | 0.01 | 0.02 | 0.05 | 0.1 |
| Embodiment 2 | 0 | 0.01 | 0.03 | 0.06 | 0.12 |
| Embodiment 3 | 0.04 | 0.06 | 0.1 | 0.13 | 0.15 |
| Control | 0.1 | 0.2 | 0.22 | 0.24 | 0.3 |
Above-mentioned test result shows that compositionss involved in the present invention are good and oligomeric to the growth result of oral cavity pathogen
Sugar has significant facilitation to the fungistatic effect of lactic acid bacteria, and oligosaccharide can lift the antibacterial effect of lactic acid bacteria.
Compositionss involved in the present invention can be applicable in oral care product, including but not limited to toothpaste, collutory, tooth
Powder, false-tooth cleaning plate, mouth spray, chewing gum, tooth patch etc..
Embodiment 4-6：
Oral care composition containing profitable probliotics is pressed by Lactobacillus paracasei, dextrinosan glucose, Arlacel-80
Following percentage by weight composition.
The oral care composition is to obtain according to the following steps：(1) span is dissolved in 30 DEG C of water；(2) breast is added
Sour bacterium, stirs 15 minutes；By above-mentioned mixed solution, -30 DEG C of lyophilizing；(3) oligosaccharide is mixed homogeneously with the lyophilized powder for being obtained,
Obtain final product.
To verify the antibacterial effect of above oral care composition, using Cell suppression test, investigate involved in the present invention
Growth inhibition effect of the compositionss to oral cavity pathogen.
By the oral care composition obtained by above-described embodiment 4,5,6 and the oral cavity pathogen phase in exponential phase
After mutually mixing, the growth curve of pathogenic bacterium is determined using absorbance method, represented with Δ OD.Δ OD nominal growths are slower, show group
Compound is better to the growth inhibitory effect of pathogenic bacterium.Matched group in test is the pathogenic bacterium for not adding compositionss.Experiment is used
Oral cavity pathogen is Streptococcus mutans, Fusobacterium nucleatum.Test result is as follows：
| 1h | 2h | 4h | 8h | 24h | |
| Embodiment 4 | 0.02 | 0.03 | 0.04 | 0.06 | 0.12 |
| Embodiment 5 | 0 | 0.01 | 0.02 | 0.04 | 0.08 |
| Embodiment 6 | 0.03 | 0.04 | 0.07 | 0.10 | 0.16 |
| Control | 0.1 | 0.2 | 0.22 | 0.24 | 0.3 |
Above-mentioned test result shows that compositionss involved in the present invention are good to the growth result of oral cavity pathogen, and adds
Span is used as the fungistatic effect that lactic acid bacteria can be significantly improved after stabilizer.
The Contrast on effect experiment of the step of embodiment 7 changes preparation method
Oral care composition containing profitable probliotics is pressed by Lactobacillus paracasei, dextrinosan glucose, Arlacel-80
Following percentage by weight composition.
The oral care composition of embodiment 7 is to obtain according to the following steps：(1) span is dissolved in 30 DEG C of water；(2) add
Enter lactic acid bacteria and oligosaccharide, stir 15 minutes；Above-mentioned mixed solution, -30 DEG C of lyophilizing are obtained final product.
The oral care composition obtained with the method (the inventive method) of embodiment 4 is contrasted, and experiment is caused with oral cavity
Pathogenic bacteria is Streptococcus mutans, Fusobacterium nucleatum.Test result is as follows：
| 1h | 2h | 4h | 8h | 24h | |
| Embodiment 4 | 0.02 | 0.03 | 0.04 | 0.06 | 0.12 |
| Embodiment 7 | 0.06 | 0.07 | 0.09 | 0.14 | 0.3 |
Above-mentioned test result shows that oral cavity composition obtained in the inventive method is good to the growth result of oral cavity pathogen,
The step of changing preparation technology can affect the fungistatic effect of lactic acid bacteria.
Embodiment 8-10
Toothpaste making process of the present invention is as follows：
1) abrasivuss, thickening agent are weighed up by formula, is stirred into powder material tank stand-by
2) by sweeting agent, in deionized water mixing and stirring is stand-by for stabilizer；
3) by wetting agent, weigh up by formula and mix stand-by in liquid tank；
4) by essence, weigh up by formula, it is stand-by.
6) vacuum system of Manufacturing medicine extract machine is opened, vacuum is evacuated to into -0.6MPa；Suction step 2 and 3 material, while opening
Dynamic agitator, by vacuum -0.75MPa is evacuated to, and is taken out and is stirred 10 minutes.
7) material in steps for importing 1, and keep vacuum in -0.4MPa, until the material in step 1 has been entered, take out
Vacuum is stirred 15 minutes to maximum (- 0.10MPa).
8) add natural essence, surfactant, the oral care composition containing profitable probliotics respectively, stir 3 minutes；Take out true
It is empty to stir 20 minutes to maximum (- 0.10MPa), obtain final product.
Toothpaste antibacterial effect is tested；
Using the method for minimal inhibitory concentration, embodiment 8, embodiment 9, the effect of the anti-cariogenic bacteria of the toothpaste of embodiment 10 are evaluated
Really, it is Streptococcus mutans and lactobacilluss to test strain.Both antibacterials are the topmost pathogenic bacterium of dental caries.
Test result is as follows：
From test result as can be seen that the toothpaste that with the addition of the oral care composition containing profitable probliotics has good resisting
The effect of cariogenic bacteria, compared with the product for being not added with compositionss, after oral care composition of the addition containing profitable probliotics, its is antibacterial
Effect is also improved.
Embodiment described above only expresses the several embodiments of the present invention, it is impossible to be interpreted as to the scope of the claims of the present invention
Restriction.It should be pointed out that for the person of ordinary skill of the art, without departing from the inventive concept of the premise,
Some deformations and improvement can also be made, these belong to protection scope of the present invention.Therefore, the protection domain of patent of the present invention
Should be defined by claims.
Claims (10)
1. a kind of oral care composition containing profitable probliotics, it is characterised in that the oral care composition is by lactic acid bacteria, many
Polysaccharide, span are constituted by following percentage by weight：
Lactic acid bacteria 20～60%
Oligosaccharide 20～60%
Span 10～30%；
Summation is 100%.
2. oral care composition according to claim 1, it is characterised in that the oral care composition is by following
Step is obtained：(1) span is dissolved in 30～40 DEG C of water；(2) lactic acid bacteria is added, is stirred 15～20 minutes, obtain mixing molten
Liquid, -10 DEG C～-30 DEG C lyophilizing；(3) oligosaccharide is mixed homogeneously with the lyophilized powder for being obtained, is obtained final product.
3. oral care composition according to claim 1, it is characterised in that the lactic acid bacteria be Lactobacillus paracasei,
One or more of bacillus bifiduss, saliva lactobacilluss.
4. oral care composition according to claim 1, it is characterised in that the oligosaccharide is Fructus Hordei Germinatus oligose Fructus Vitis viniferae
One or more of sugar, dextrinosan glucose, coupling sugar glucose, Pan pool glucose.
5. oral care composition according to claim 1, it is characterised in that the span is Arlacel-20, Arlacel-80
One or more of.
6. application of the oral care composition described in claim 1 in oral care implement.
7. application of the oral care composition described in claim 1 in toothpaste, it is characterised in that each composition contains in toothpaste
Amount is as follows, by weight percentage：
8. application according to claim 7, it is characterised in that the wetting agent is in Sorbitol, glycerol, erythritol
More than one.
9. application according to claim 7, it is characterised in that the abrasivuss be silicon dioxide, calcium phosphate dibasic dihydrate,
One or more of Calcium Carbonate.
10. application according to claim 7, it is characterised in that the surfactant is natural soap tree extractive, the moon
One or more of cinnamic alcohol sodium sarcosinate, sodium cocoyl glutamate.
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| CN201610662975.XA CN106562923B (en) | 2016-08-12 | 2016-08-12 | Oral care composition containing profitable probliotics and its application in toothpaste |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110772475A (en) * | 2019-12-10 | 2020-02-11 | 广州瑞誉化工科技有限公司 | Probiotic toothpaste |
| CN111632021A (en) * | 2020-07-27 | 2020-09-08 | 浙江爱尚日用品有限公司 | Probiotics toothpaste for preventing gingival atrophy |
| CN112754987A (en) * | 2021-03-06 | 2021-05-07 | 博雅(广州)生物科技研究院有限公司 | Oral care composition containing probiotics and application thereof |
| TWI748395B (en) * | 2020-03-31 | 2021-12-01 | 豐華生物科技股份有限公司 | Composition for relieving allergies and improving exercise performance and uses thereof |
| CN115006341A (en) * | 2022-07-21 | 2022-09-06 | 重庆登康口腔护理用品股份有限公司 | Oral cleaning and nursing composition capable of adjusting oral micro-ecological balance and preparation method thereof |
| CN115708799A (en) * | 2022-12-16 | 2023-02-24 | 广州悦创实业有限公司 | Mild type dental caries prevention children liquid toothpaste and preparation method thereof |
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Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110772475A (en) * | 2019-12-10 | 2020-02-11 | 广州瑞誉化工科技有限公司 | Probiotic toothpaste |
| TWI748395B (en) * | 2020-03-31 | 2021-12-01 | 豐華生物科技股份有限公司 | Composition for relieving allergies and improving exercise performance and uses thereof |
| CN111632021A (en) * | 2020-07-27 | 2020-09-08 | 浙江爱尚日用品有限公司 | Probiotics toothpaste for preventing gingival atrophy |
| CN112754987A (en) * | 2021-03-06 | 2021-05-07 | 博雅(广州)生物科技研究院有限公司 | Oral care composition containing probiotics and application thereof |
| CN115006341A (en) * | 2022-07-21 | 2022-09-06 | 重庆登康口腔护理用品股份有限公司 | Oral cleaning and nursing composition capable of adjusting oral micro-ecological balance and preparation method thereof |
| CN115006341B (en) * | 2022-07-21 | 2023-12-19 | 重庆登康口腔护理用品股份有限公司 | Oral cavity cleaning and nursing composition capable of regulating oral cavity microecological balance and preparation method thereof |
| CN115708799A (en) * | 2022-12-16 | 2023-02-24 | 广州悦创实业有限公司 | Mild type dental caries prevention children liquid toothpaste and preparation method thereof |
| CN115708799B (en) * | 2022-12-16 | 2024-03-12 | 广州悦创实业有限公司 | Mild caries-preventing children liquid toothpaste and preparation method thereof |
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| CN106562923B (en) | 2019-02-26 |
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