CN106821950A - The oral care composition and its application of a kind of antibacterial and whitening - Google Patents
The oral care composition and its application of a kind of antibacterial and whitening Download PDFInfo
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- CN106821950A CN106821950A CN201710049750.1A CN201710049750A CN106821950A CN 106821950 A CN106821950 A CN 106821950A CN 201710049750 A CN201710049750 A CN 201710049750A CN 106821950 A CN106821950 A CN 106821950A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/99—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from microorganisms other than algae or fungi, e.g. protozoa or bacteria
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/55—Phosphorus compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/52—Stabilizers
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Abstract
The invention discloses a kind of antibacterial and the oral care composition of whitening, it contains profitable probliotics, green-tea extract, phytic acid, and three of the above material is calculated as 10 in mass ratio：(10~20)：(1~10), the probiotics is one or two mixing in lactobacillus paracasei, saliva Bacillus acidi lactici, and the probiotics is by sterilization treatment.In composition of the invention, probiotics and green-tea extract are activating agent, and phytic acid is stabilizer, in the presence of phytic acid, the compounding effect of probiotics and Tea Polyphenols is greatly improved, composition of the invention is applied in mouthrinse product, be there is good antibacterial, suppressed bacterial plaque, whitening, pre- anti-caries, cleaning oral cavity, healthy gum.
Description
Technical field
The present invention relates to the composition in oral cavity, more particularly to the MC combination with antibacterial and whitening double effects
Thing and its application.
Background technology
Oral health is the important component of health, aobvious according to the investigation of Third National oral health epidemiological
Show, less than 15%, the illness rate of Primary Caries disease is 66% to China's the elderly's periodontal health rates within 5 years old, a middle-aged person and old age
The illness rate of people's dental caries is respectively 88.1% and 98.4%, and oral health situation allows of no optimist.
In Oral health behaviours system, between oral microorganism, between oral microorganism and host, remain a kind of dynamic
State is balanced, and forms an interdependence, the system of mutually restriction.Under normal circumstances, Oral health behaviours can keep dynamic equilibrium,
But the buffer capacity of this dynamic equilibrium, than relatively limited, this dynamic equilibrium is easily broken in the effect of some internal and external factors, is made
Oral environment changes, and causes flora imbalance so as to trigger disease.For example：The growth of porphyromonas gingivalis easily triggers periodontal
Inflammation, Streptococcus mutans, the growth of Bacillus acidi lactici easily trigger the mouth diseases such as carious tooth.Periodontosis and dental caries are current most common mouths
The main pathogenic of chamber disease, dental caries and periodontosis --- the bacterial plaque of dental surface is attached on, is that one kind has relatively strong resisting
The biomembrane of the property of medicine, general bacteriostatic agent cannot thoroughly be killed the bacterium in it.
The oral health of current compatriots is mainly brushes teeth, but brushes teeth and can only clean 25% or so of oral cavity area, also very
Many mouth areas such as teeth space, tongue fur, oral cavity Nei Hedeng regions cannot all be cleaned well.Therefore, after after brushing, mouth is used
Chamber cleaning-nursing liquid, is conducive to further cleaning oral cavity, reduces oral bacteria, prevents oral problem.
Gargle at present on the market is less, and major part is prepared from using the raw material of chemical synthesis, and often
With the addition of fluoride, such as sodium fluoride or sodium monofluorophosphate reaches mothproof effect, but due to less than the 6 years old function of deglutition of children
Complete without development, excessive intake fluorine element can cause den tal fluorosis, or even fluorosis of bone occurs, have a strong impact on the strong of children
Health.Meanwhile, a large amount of drug resistances for being possible to cause bacterium using chemical antiseptic, not only reducing effect, can more cause bigger
Harm.Therefore a use probiotics is developed to be conducive to promoting with natural extract compounding, the oral nursing liquid of safely edible
Enter the oral health of compatriots.
Probiotics can produce some metabolites, such as organic acid, hydrogen peroxide, ablastins, anti-attachment in process of production
The compositions such as agent, cohesion molecule, with antimicrobial effect.It is harmful thin that some special probiotics have been shown to have suppression oral cavity
The effect of bacteria growing.
Patent publication No. CN 101190239A disclose a kind of product containing LP lactic acid bacterias, are used to suppress bacterium to cause
Odontopathy, this product include multiple LP lactic acid bacterias, odontopathy bacterial growth can be suppressed.
Patent application publication CN 102470151A provide it is a kind of it is wide to disease in mouth reason bacterium spectrum, wind can be manufactured
The novel lactic bacterial strain of the fermentate that taste is good, hobby property is excellent, and the disease in mouth being made of the phase prevention, improve or
Person's therapeutic agent.
Patent application publication CN 103119153A disclose a kind of bacterium bacterial strain, it is characterised in that they present and are directed to
The biological inhibitory activity of raw dental caries.Also disclose medicine and/or probiotics/prebiotic promotor composition, function etc. can be used for treatment and/
Or prevention oral infections disease, at least one bacterial strain and/or at least one biologically active peptide preferably described in the present invention of carious tooth
Or its combination.
Patent application publication CN103298924A provides plant lactobacillus CECT7481 and short breast comprising effective dose
The composition of bacillus CECT7480, with the application improved in terms of oral health.
Patent application publication CN104140937A provides a kind of Lactobacillus plantarum KLDS1001, and make a variation hammer to oral cavity
Bacterium is inhibited, can be as a kind of adding ingredient of oral health-care product, for oral health.
Patent application publication CN 103384526A are related to, as sensuously neutral oral cavity nursing agent, particularly be used for
Pre- dental calculus preventing, microorganism or its fragment for anti-caries agent and/or anti-oral malodor agent.
Patent application publication CN105434322A discloses a kind of toothpaste containing oral cavity probiotics, and clinical test shows
The toothpaste has good curative effect to gingivitis, periodontitis, halitosis.
Patent application publication CN105534875A discloses a kind of antibacterial antiallergic perception compositions for oral-cavity article, bag
Containing anti-sensitive agent and probiotics.Reorganization compound can help user to solve bleeding gums, halitosis, tooth mobility, sensitivity of tooth
Etc. symptom.
Green-tea extract has natural green tea to be obtained by alcoholic extraction, contains abundant Tea Polyphenols.Research shows that Tea Polyphenols has
There are stronger antioxidation, especially ester catechin EGCG, its reproducibility is even up to 100 times of the different bad hematic acid of L-.And it is anti-
Oxidation susceptibility strengthens with the rising of temperature.Tea Polyphenols in addition to antioxidation, also with bacteriostasis, such as to grape ball
Bacterium, Escherichia coli, hay bacillus etc. have inhibitory action.Peculiar smell in the adsorbable food of Tea Polyphenols, therefore with certain deodorant
Effect.In for oral care implement, with sterilized, mothproof, fresh breath function.
Patent CN 101627965B disclose a kind of mouthwash and preparation method thereof, and the active component of the mouthwash includes
Tea Polyphenols, have functions that it is multiple prevent and treat oral problem, such as prevent and treat carious tooth, anti-inflammation and sterilization, desensitization, hemostasis, fresh breath etc. is made
With.
Patent CN 103315938B disclose a kind of anti-oxidative mouthwash, and with the addition of 0.5-2% green tea is activity
Composition.
Natural green tea extract is used as a kind of natural safe antimicrobial component, but the more difficult stable existence in rapids oral fluid.Hold
Easily influenceed by temperature, heavy metal, light irradiation, caused inactivation.
It is described above or to apply the growth that probiotics suppresses harmful bacteria in the prior art, or apply Tea Polyphenols
Carry out anti-inflammation and sterilization, so as to prevent and treat oral problem.Probiotics or Tea Polyphenols are individually used, fungistatic effect is not notable.And this
Inventor has found by long-term research, and in the presence of phytic acid, there is significant antibacterial to imitate for the combination of probiotics and Tea Polyphenols
Really, and there is whitening effect.
The content of the invention
Present invention aim at a kind of oral care composition of antibacterial whitening of offer, the stabilization of the oral care composition
Property good, low cost, and with efficient antibacterial and whitening effect, be adapted to popularization and application in oral care product.
To achieve the above object, the present invention is adopted the following technical scheme that：
A kind of antibacterial and the oral care composition of whitening, it contains profitable probliotics, green-tea extract, phytic acid, three of the above
Material is calculated as 10 in mass ratio：(10~20)：(1~10).
Preferably, the probiotics is one or two mixing in lactobacillus paracasei, saliva Bacillus acidi lactici.
Preferably, the probiotics is by sterilization treatment.
Preferably, the sterilization treatment is that ultraviolet irradiates more than 1 hour.
Preferably, the green-tea extract is ethanol extract, content >=95% of Tea Polyphenols.
Preferably, probiotics, green-tea extract, phytic acid three are calculated as 10 in mass ratio：20：8.
Above-mentioned antibacterial and the oral care composition of whitening are applied in mouthwash, and the addition of composition is that mouthwash is total
The 0.02~3% of weight.
The mouthwash also include NMF 5~30%, sweetener 0.01~0.3%, natural essence 0.01~0.5%,
Natural solubilizer 0.1~3%, nutritional ingredient 0.01~1%, balance of deionized water.
The NMF is one or more mixing in sorbierite, glycerine, propane diols, and the sweetener is xylose
One or more mixing in alcohol, tri-chloro galactose type sugar, steviol glycoside, saccharin sodium, the nutritional ingredient is vitamin
C, vitamin E, FOS, zinc gluconate, calcium lactate, one or more mixing of calcium glycerophosphate, it is described natural
Essence is that the one or two kinds of of peppermint, sweet orange, strawberry etc. is mixed above, the solubilizer be rilanit special, poloxamer,
One or two kinds of combination of the above in tween.
The preparation method of above-mentioned mouthwash, it is characterised in that comprise the following steps：
1) deionized water in half amount formula is taken, solubilizer is dissolved in deionized water, under stirring condition, added fragrant
Essence, stirs stand-by；
2) remaining deionized water is taken, phytic acid, sweetener, green-tea extract, probiotics, nutritional ingredient is put into successively, mixed
Conjunction stirs stand-by；
3) weigh up NMF to be added in step 1, stir,
4) by step 2) the aqueous solution, be added to step 1) in, stirring.
In composition of the invention, probiotics and green-tea extract are activating agent, and phytic acid is stabilizer, in depositing for phytic acid
Under, the compounding effect of probiotics and Tea Polyphenols is greatly improved.
In the present compositions, probiotics by sterilization treatment, stability is greatly improved, phytic acid on the one hand can drop
The pH value of low system, is conducive to keeping the stability of probiotics, and on the other hand, green-tea extract difficult stabilization in mouthwash is deposited
Phytic acid is being added to greatly improve the stability of green-tea extract, in addition, phytic acid can also be with the pigment knot of some macromoleculars
Close, pigment can be prevented to be remained on tooth.And some metabolites of probiotics include that peroxide also has tooth-whitening
Effect.Therefore, composition of the invention, except effect of antibacterial, also with stronger white-skinned face function.
Composition of the invention is applied in mouthrinse product, with good antibacterial, suppresses bacterial plaque, whitening, pre-
Anti-caries, cleaning oral cavity, effect of healthy gum.
Specific embodiment
The present invention is further described in detail below by specific implementation example.
Embodiment 1
A kind of antibacterial and the oral care composition of whitening, it contains profitable probliotics, green-tea extract, phytic acid, three of the above
Material is calculated as 10 in mass ratio：(10~20)：(1~10).
In further preferred scheme, probiotics, green-tea extract, the mass ratio of phytic acid three are 10：20：8.
The probiotics is one or two mixing in lactobacillus paracasei, saliva Bacillus acidi lactici.The probiotics warp
Cross sterilization treatment.The sterilization treatment is that ultraviolet irradiates more than 1 hour.
The green-tea extract is ethanol extract, content >=95% of Tea Polyphenols.
Embodiment 2
The composition of embodiment 1 is applied in mouthwash, the addition of the combination is mouthwash gross weight
0.02~3%.Specifically, the mouthwash also includes NMF 5~30%, sweetener 0.01~0.3%, natural essence 0.01
~0.5%, natural solubilizer 0.1~3%, nutritional ingredient 0.01~1%, balance of deionized water.
The NMF is one or more mixing in sorbierite, glycerine, propane diols, and the sweetener is xylose
One or more mixing in alcohol, tri-chloro galactose type sugar, steviol glycoside, saccharin sodium, the nutritional ingredient is vitamin
C, vitamin E, FOS, zinc gluconate, calcium lactate, one or more mixing of calcium glycerophosphate, it is described natural
Essence is that the one or two kinds of of peppermint, sweet orange, strawberry etc. is mixed above, the solubilizer be rilanit special, poloxamer,
One or two kinds of combination of the above in tween.
The preparation method of above-mentioned mouthwash, it is characterised in that comprise the following steps：
1) deionized water in half amount formula is taken, solubilizer is dissolved in deionized water, under stirring condition, added fragrant
Essence, stirs stand-by；
2) remaining deionized water is taken, phytic acid, sweetener, green-tea extract, probiotics, nutritional ingredient is put into successively, mixed
Conjunction stirs stand-by；
3) weigh up NMF to be added in step 1, stir 10 minutes,
4) by step 2) the aqueous solution, be added to step 1) in, stir 20 minutes, mouthrinse product.
Performance, the efficacy test of the mouthwash of embodiment 3
First, experimental formula design
Table one, mouthwash formula table
Above experimental group is made mouthwash according to the method for embodiment 2, carries out efficacy test.
2nd, study on the stability：
Gargle obtained by experimental group 3-4 is respectively put into room temperature and 45 degree of baking oven, tea in periodic detection product
The content of polyphenol, testing result is as shown in the table：
Table two, polyphenol content situation of change
From in terms of effect, the formula of phytic acid is with the addition of, the stability of Tea Polyphenols is significantly improved relative to the formula without phytic acid, this
Illustrate that phytic acid is conducive to keeping the stability of Tea Polyphenols.
3rd, antibiotic effect is investigated
To evaluate the antibacterial effect of different product, by the product obtained by experimental group 1,2,3,5 and in exponential phase
Oral cavity pathogen --- after Streptococcus mutans are mutually mixed, using absorbance method determine pathogenic bacteria growth curve, with Δ OD
Represent.Δ OD nominal growths are slower, show that mouthwash is good to the growth inhibitory effect of pathogenic bacteria.Test result is as shown in the table.
| Embodiment 1 | Embodiment 2 | Embodiment 3 | Embodiment 5 | |
| 0h | 0 | 0 | 0 | 0 |
| 2h | 0.01 | 0.02 | 0.03 | 0.05 |
| 5h | 0.02 | 0.05 | 0.07 | 0.12 |
| 10h | 0.05 | 0.08 | 0.12 | 0.17 |
| 15h | 0.08 | 0.12 | 0.17 | 0.23 |
| 20h | 0.1 | 0.15 | 0.20 | 0.29 |
Show from test result, experimental group 1, experimental group 2, experimental group 3 all have good antibacterial effect relative to experimental group 5
Really.Wherein, preferably, this explanation probiotics has certain trade-off effect to the fungistatic effect of embodiment 1 with green-tea extract compounding.
4th, white-skinned face function is investigated
To evaluate the whitening effect of different product, respectively with the product soaking and dyeing obtained by 20ml experimental groups 1,2,3,5
Baurodont afterwards, daily immersion 2 times sooner or later, each 3min, continuous dipping 7 days, using baurodont color before and after color difference meter test immersion
Changes delta L values, test result is as shown in the table.
| Experimental group 1 | Experimental group 2 | Experimental group 3 | Experimental group 5 | |
| Δ L values after 7 days | 8.42 | 5.34 | 6.28 | 1.19 |
It can be seen from the results above that with the addition of probiotics, phytic acid, the mouthwash of tea polyphenol extract thing with respect to blank
With significant whitening effect, and the effect that three compounds, it is better than and individually adds one or two composition.
The announcement and teaching of book according to the above description, those skilled in the art in the invention can also be to above-mentioned embodiment party
Formula is changed and changed.Therefore, the invention is not limited in specific embodiment disclosed and described above, to of the invention
Some modifications and changes should also be as falling into scope of the claims of the invention.Although additionally, being used in this specification
Some specific terms, but these terms are merely for convenience of description, do not constitute any limitation to the present invention.
Claims (10)
1. a kind of antibacterial and the oral care composition of whitening, it is characterised in that containing profitable probliotics, green-tea extract, phytic acid, with
Upper three kinds of materials are calculated as 10 in mass ratio：(10~20)：(1~10).
2. antibacterial as claimed in claim 1 and the oral care composition of whitening, it is characterised in that：The probiotics is secondary dry
One or two mixing in Lactobacillus paracasei, saliva Bacillus acidi lactici.
3. antibacterial as claimed in claim 1 or 2 and the oral care composition of whitening, it is characterised in that：The probiotics warp
Cross sterilization treatment.
4. antibacterial as claimed in claim 3 and the oral care composition of whitening, it is characterised in that：The sterilization treatment for
Ultraviolet irradiates more than 1 hour.
5. antibacterial as claimed in claim 1 and the oral care composition of whitening, it is characterised in that：The green-tea extract is
Ethanol extract, content >=95% of Tea Polyphenols.
6. antibacterial as claimed in claim 1 and the oral care composition of whitening, it is characterised in that：Probiotics, green tea are extracted
Thing, phytic acid three are calculated as 10 in mass ratio：20：8.
7. application of the antibacterial and the oral care composition of whitening described in claim 1 to 6 any one in mouthwash, its
It is characterized as：The addition of composition is the 0.02~3% of mouthwash gross weight.
8. application as claimed in claim 7, it is characterised in that：The mouthwash also includes NMF 5~30%, sweetener
0.01~0.3%, natural essence 0.01~0.5%, natural solubilizer 0.1~3%, nutritional ingredient 0.01~1% are balance of to go
Ionized water.
9. application as claimed in claim 8, it is characterised in that：The NMF is the one kind in sorbierite, glycerine, propane diols
Or two or more mixing, the sweetener be xylitol, tri-chloro galactose type sugar, steviol glycoside, saccharin sodium in one or two with
Upper mixing, the nutritional ingredient is vitamin C, vitamin E, FOS, zinc gluconate, calcium lactate, calcium glycerophosphate
One or more mixing, the natural essence is that the one or two kinds of of peppermint, sweet orange, strawberry etc. is mixed above, described
Solubilizer is the one or two kinds of combination of the above in rilanit special, poloxamer, tween.
10. the preparation method of the mouthwash described in claim 8, it is characterised in that comprise the following steps：
1) deionized water in half amount formula is taken, solubilizer is dissolved in deionized water, under stirring condition, add essence, stirred
Mix uniform stand-by；
2) remaining deionized water is taken, phytic acid, sweetener, green-tea extract, probiotics, nutritional ingredient is put into successively, mixing is stirred
Mix uniform stand-by；
3) weigh up NMF and be added to step 1) in, stirring,
4) by step 2) the aqueous solution, be added to step 1) in, stirring.
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Cited By (12)
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| CN107683999A (en) * | 2017-08-24 | 2018-02-13 | 善恩康生物科技（苏州）有限公司 | Be advantageous to the probiotics solid beverage of oral health |
| CN108126128A (en) * | 2018-02-02 | 2018-06-08 | 上海哈美实业发展有限公司 | A kind of oral antimicrobial gelling agent and preparation method thereof |
| CN108514112A (en) * | 2018-03-12 | 2018-09-11 | 广东康侨药业有限公司 | A kind of alimentation composition and application thereof improving oral health |
| CN108813626A (en) * | 2018-06-07 | 2018-11-16 | 广州普正生物科技有限公司 | A kind of compound probiotic chewing soft capsule of tooth-whitening |
| CN109602630A (en) * | 2019-01-24 | 2019-04-12 | 四川工商职业技术学院 | A kind of antibacterial skin-whitening liquid soap |
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