CN107897881A - A kind of probiotic composition for being used to improve oral health - Google Patents
A kind of probiotic composition for being used to improve oral health Download PDFInfo
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- CN107897881A CN107897881A CN201710978664.9A CN201710978664A CN107897881A CN 107897881 A CN107897881 A CN 107897881A CN 201710978664 A CN201710978664 A CN 201710978664A CN 107897881 A CN107897881 A CN 107897881A
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- 239000000203 mixture Substances 0.000 title claims abstract description 34
- 239000006041 probiotic Substances 0.000 title claims abstract description 30
- 235000018291 probiotics Nutrition 0.000 title claims abstract description 30
- 230000000529 probiotic effect Effects 0.000 title claims abstract description 20
- 210000000214 mouth Anatomy 0.000 claims abstract description 28
- 241001608472 Bifidobacterium longum Species 0.000 claims abstract description 11
- 241000218588 Lactobacillus rhamnosus Species 0.000 claims abstract description 11
- 229940009291 bifidobacterium longum Drugs 0.000 claims abstract description 11
- 240000002605 Lactobacillus helveticus Species 0.000 claims abstract description 10
- 235000013967 Lactobacillus helveticus Nutrition 0.000 claims abstract description 10
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims abstract description 10
- 229940054346 lactobacillus helveticus Drugs 0.000 claims abstract description 10
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims description 6
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- 229940035034 maltodextrin Drugs 0.000 claims description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 4
- 241000193830 Bacillus <bacterium> Species 0.000 claims description 3
- 229960005070 ascorbic acid Drugs 0.000 claims description 3
- 235000010323 ascorbic acid Nutrition 0.000 claims description 3
- 239000011668 ascorbic acid Substances 0.000 claims description 3
- 210000000481 breast Anatomy 0.000 claims description 3
- SHZGCJCMOBCMKK-UHFFFAOYSA-N D-mannomethylose Natural products CC1OC(O)C(O)C(O)C1O SHZGCJCMOBCMKK-UHFFFAOYSA-N 0.000 claims 1
- SHZGCJCMOBCMKK-JFNONXLTSA-N L-rhamnopyranose Chemical compound C[C@@H]1OC(O)[C@H](O)[C@H](O)[C@H]1O SHZGCJCMOBCMKK-JFNONXLTSA-N 0.000 claims 1
- PNNNRSAQSRJVSB-UHFFFAOYSA-N L-rhamnose Natural products CC(O)C(O)C(O)C(O)C=O PNNNRSAQSRJVSB-UHFFFAOYSA-N 0.000 claims 1
- 206010006326 Breath odour Diseases 0.000 abstract description 3
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- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 8
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- 238000003379 elimination reaction Methods 0.000 description 1
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- 235000013305 food Nutrition 0.000 description 1
- 208000007565 gingivitis Diseases 0.000 description 1
- 239000003102 growth factor Substances 0.000 description 1
- 230000003862 health status Effects 0.000 description 1
- 230000005745 host immune response Effects 0.000 description 1
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- 229940051866 mouthwash Drugs 0.000 description 1
- 230000000474 nursing effect Effects 0.000 description 1
- 208000028169 periodontal disease Diseases 0.000 description 1
- 210000004261 periodontium Anatomy 0.000 description 1
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- 235000013343 vitamin Nutrition 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/135—Bacteria or derivatives thereof, e.g. probiotics
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L31/00—Edible extracts or preparations of fungi; Preparation or treatment thereof
- A23L31/10—Yeasts or derivatives thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2400/00—Lactic or propionic acid bacteria
- A23V2400/11—Lactobacillus
- A23V2400/147—Helveticus
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2400/00—Lactic or propionic acid bacteria
- A23V2400/11—Lactobacillus
- A23V2400/175—Rhamnosus
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2400/00—Lactic or propionic acid bacteria
- A23V2400/51—Bifidobacterium
- A23V2400/533—Longum
Abstract
The invention discloses a kind of probiotic composition for being used to improve oral health, yeast, Lactobacillus helveticus, Lactobacillus rhamnosus and bifidobacterium longum are included in said composition, viable count is 5,000,000,000 CFU in every gram of composition, wherein, 5.2 hundred million CFU of yeast, 26.8 hundred million CFU of Lactobacillus helveticus, 14.4 hundred million CFU of Lactobacillus rhamnosus, 3.6 hundred million CFU of bifidobacterium longum, it is disclosed in this invention to be used to improve the probiotics raw material selected by the probiotic composition of oral health, it is raw-food material, product is direct-edible, edible safety.After edible, it can improve intestinal flora while completing to adjust oral cavity flora balance, further improve the oral health issue such as halitosis caused by intestinal health problem.
Description
Technical field
It is more particularly to a kind of to be used to improve oral health the present invention relates to a kind of composition for being used to improve oral health
Probiotic composition.
Background technology
Oral health is the important component of health.The World Health Organization (WHO) determines dental health for people
One of body ten big standards of health.The standard of dental health is：Tooth is clean and tidy, without carious tooth, without pain, gum color and luster is normal, without going out
Blood phenomenon.It can be seen from the above that oral health refers to there is good oral hygiene, sound oral cavity function and no mouth disease.
Oral hygiene focuses on controlling bacterial plaque, elimination dirt and swill, strengthens physiological stimulation, makes oral cavity and tooth
Jaw system has the good environment of a cleaning health, so as to play its physiological function, safeguards oral health.
Oral health directly or indirectly influences whole body health.It is hard that mouth disease such as dental caries, periodontal disease etc. can destroy tooth
Supporting tissue around tissue and tooth, in addition to the functions such as chewing, speech, beauty are influenced, can also cause social interaction difficulty and the heart
Manage obstacle.Some microorganism long-term existence can cause in oral cavity or aggravate some general diseases such as coronary heart disease, diabetes etc.,
Whole body health is endangered, influences quality of life.
The main oral disease in two whole world：
1st, (carious tooth) is decayed tooth：Bacterium infection causes demineraliting and destroys the sclerous tissues of tooth.
2nd, periodontosis：Disease combines, and influences one or more periodontium, and most commonly patch induction so far is scorching
Disease property disease (gingivitis, periodontitis).
The relevant health status of other oral cavity floras：Halitosis, ear nose larynx infection (pharyngitis/tympanitis).
Streptococcus mutans (Streptococcus mutans) is the streptococcus of accounting example maximum in the natural flora of oral cavity
In one kind, be dental plaque one of main component.The oral cavity of the mankind is filled with bacterium.Under conditions of damp and hot, kind more than 700 is had
Bacterium grows up strong and sturdy in the oral cavity, including streptococcus mutans, this is one of main component of dental plaque.Streptococcus mutans is in layer
Ground is adsorbed on tooth, is formed so-called " biomembrane ".They consume carbohydrate, produce acid, corrode the glaze layer of tooth, cause tooth
Hole.
For example, scientists in 2009 find that streptococcus salivarius can reduce the accumulation of streptococcus mutans biomembrane, it is this
Streptococcus is present in oral cavity on tongue and other soft tissues.Dental caries are to betide the bacterial infection disease of tooth hard tissue, in mouth
Incidence highest in chamber disease, streptococcus mutans are the Main Pathogenic Bacterias of dental caries, and streptococcus mutans has strong cariogenicity mainly to take
Certainly in its production acidity and acid resistance.
Bacterium/plaque accumulation causes various focusing depths represented.If periodontitis can be evolved into by not treating：Bacterium penetrates into teeth roots
Bone and destroy it；It is one of main reason of global loss of tooth, especially the elderly.
Probiotics：2001, the World Food Programme (FAO) and the World Health Organization (WHO) also did probiotics as follows
Definition：By absorbing appropriate amount, the health to eater can play the viable bacteria of useful effect.
So far, the probiotics that scientist has found generally is divided into three major types, including：1. lactobacillus class
(such as lactobacillus acidophilus, Lactobacillus casei, Lactobacillus rhamnosus)；2. Bifidobacterium class (such as bifidobacterium longum, short bifid bar
Bacterium, bifidobacterium bifidum etc.)；3. gram-positive cocci (such as streptococcus fecalis, galactococcus).In addition, there are some saccharomycete
The category of probiotics can be also included into enzyme.
Probiotics may include the mechanism of enforcement effect in terms of oral health to compete attachment sites sum, competition nutriment
And growth factor, produce acid antimicrobialization product, strengthen host immune response, suppress the proinflammatory cytokines of pathogenic bacterium inducing because
Son, adheres to so as to suppress harmful bacteria and strengthens emptying, and suppresses the effect such as growth of pathogen, influences exempting from locally and systemically
Epidemic disease is reacted, final antagonism pathogen, reduces inflammation and disorganization.
At this stage in terms of oral health care, the product such as most common toothpaste, mouthwash, its principle is to remove mouth
All microorganisms in chamber, to oral cavity thoroughly " clean ".But for the body that oral microorganism flora has been lacked of proper care, this
Method can not be effectively improved oral healthy condition, and the state of oral cavity flora imbalance still remains, and reason, which is that, is carrying out oral cavity
After microorganism " cleaning ", oral microorganism has a process of reconstruction, in reconstruction process, since harmful bacteria often has opposite life
Long advantage, will occur the situation of oral microorganism flora imbalance again, and oral health issue can not be solved well.
The content of the invention
In order to solve the above technical problems, be used to improve the probiotic composition of oral health the present invention provides a kind of, with
Reaching effectively improves oral microorganism colony balance and forms a kind of sustainable Flora distribution, is effectively improved oral microorganism
Colony balance, improves the purpose of oral health.
To reach above-mentioned purpose, technical scheme is as follows：
It is a kind of to be used to improve the probiotic composition of oral health, include yeast, Lactobacillus helveticus, sandlwood in said composition
Sugared lactobacillus and bifidobacterium longum.
In such scheme, viable count is 5,000,000,000 CFU in every gram of composition, wherein, 5.2 hundred million CFU of yeast, Switzerland's breast bar
26.8 hundred million CFU of bacterium, 14.4 hundred million CFU of Lactobacillus rhamnosus, 3.6 hundred million CFU of bifidobacterium longum.
In such scheme, 4mg ascorbic acid is further included in every gram of composition, surplus is maltodextrin.
In such scheme, the yeast is edible yeast, and the Lactobacillus helveticus is Lactobacillus helveticus Rosell-52,
The Lactobacillus rhamnosus is Lactobacillus rhamnosus Rosell-11, and the bifidobacterium longum is bifidobacterium longum Rosell-175.
In further technical solution, the composition is powdered.
In further technical solution, the composition using when reconstituted with water, for gargling, stop one section in the oral cavity
Directly swallowed after time.
Through the above technical solutions, have solely provided by the present invention for the probiotic composition selection for improving oral health
The probiotics strain product of special function is combined, and using the synergistic effect between bacterial strain, establishes biological barrier, suppresses to cause a disease
Bacterium, maintains the oral cavity flora ratio of health, reduces dental plaque, prevents and improve common oral health issue.
With it is simple use conventional oral health care products compared with, probiotic products are applied to oral health, use with
Bacterium is antibacterial, the method for fungus treatment, adjusts the state of oral microorganism flora, oral microorganism flora is in a kind of healthy
Equilibrium state, so as to prevent and improve a series of oral health issues caused by oral microorganism flora imbalance.It is and normal
Oral health care products are advised, are only to suppress or kill the microorganism in oral cavity completely, for adjusting oral microorganism flora
Balance is not improved effect without directly effective effect to the state in a healthy and balanced way for adjusting oral microorganism flora.
Meanwhile the probiotics raw material selected by the present invention, it is raw-food material, product is direct-edible, edible safety.
After edible, it can improve intestinal flora while completing to adjust oral cavity flora balance, further improve because intestinal health is asked
The oral health issues such as halitosis caused by topic.
Embodiment
The technical solution in the embodiment of the present invention will be clearly and completely described below.
It is used to improve the probiotic composition of oral health the present invention provides a kind of, using the method for biological therapy, with
Beneficial bacterium suppression pathogenic bacteria in itself and the ability being at war with pathogenic bacteria, effectively improve oral microorganism colony balance
And a kind of sustainable Flora distribution is formed, oral microorganism colony balance is effectively improved, improves oral health.
Specific embodiment is as follows：
It is a kind of to be used to improve the probiotic composition of oral health, include 5.2 hundred million CFU edible ferment in every 1 gram of composition
Mother, 26.8 hundred million CFU Lactobacillus helveticus Rosell-52,14.4 hundred million CFU Lactobacillus rhamnosus Rosell-11 and 3.6 hundred million CFU long are double
Discrimination bacillus Rosell-175, viable count is 5,000,000,000 CFU in every 1 gram of composition.4mg Vitamin Cs have been further included in every 1 gram of composition
Acid, surplus are maltodextrin.
The raw materials such as bacterium powder obtain powder product after mixing, and when use is reconstituted with water, for gargling, is stopped in the oral cavity
It can directly be swallowed after a period of time, be effectively improved the state of oral health flora.
Human trial
Experiment process：Healthy School Children is selected, mouth cavity daily nursing is carried out using the product of the present invention, investigates in oral cavity
The change of streptococcus mutans.
Study subject：150 Healthy School Childrens (7-14 Sui)
Test method：
150 children are divided into 2 groups, are respectively 50 people of placebo (A groups) and 100 people of test group (B)；
A groups take maltodextrin, and B groups are taken the powder provided by the invention for containing 5,000,000,000 probiotics, are mixed with powder
Lactobacillus helveticus, Lactobacillus rhamnosus, long Bifidobacterium Bifidum and edible yeast, and ascorbic acid and maltodextrin.
14 days oral health cares are carried out using probiotic composition powder.
Daily noon, giving 1 bag of probiotic composition powder added 20 milliliters of water after the meal, and powder is reconstituted as liquid.
Owner pours into the liquid after reconstituting in mouth, gargles 1 minute, swallows liquid.
After 2 weeks, the situation of streptococcus mutans in subject oral cavity is analyzed, concrete outcome such as table 1：
The situation and demographics of streptococcus mutans in 1 placebo of table and test group oral cavity
It can be seen that by above-mentioned data, after placebo takes maltodextrin, streptococcus mutans quantity does not occur in oral cavity
Change；Test group is after daily probiotics 2 weeks, and streptococcus mutans quantity is generally decreased obviously (p in oral cavity<0.001), by
Probiotic products in this explainable present invention can effectively reduce the streptococcus mutans quantity in oral cavity, so as to reduce by deformation chain
The risk of coccigenic oral health issue.
The foregoing description of the disclosed embodiments, enables professional and technical personnel in the field to realize or use the present invention.
A variety of modifications to these embodiments will be apparent for those skilled in the art, as defined herein
General Principle can be realized in other embodiments without departing from the spirit or scope of the present invention.Therefore, it is of the invention
The embodiments shown herein is not intended to be limited to, and is to fit to and the principles and novel features disclosed herein phase one
The most wide scope caused.
Claims (6)
1. a kind of probiotic composition for being used to improve oral health, it is characterised in that yeast, Switzerland's breast are included in said composition
Bacillus, Lactobacillus rhamnosus and bifidobacterium longum.
A kind of 2. probiotic composition for being used to improve oral health according to claim 1, it is characterised in that every gram of institute
It is 5,000,000,000 CFU to state viable count in composition, wherein, 5.2 hundred million CFU of yeast, 26.8 hundred million CFU of Lactobacillus helveticus, Lactobacillus rhamnosus
14.4 hundred million CFU, 3.6 hundred million CFU of bifidobacterium longum.
A kind of 3. probiotic composition for being used to improve oral health according to claim 2, it is characterised in that every gram of institute
State and 4mg ascorbic acid has been further included in composition, surplus is maltodextrin.
A kind of 4. probiotic composition for being used to improve oral health according to claim 1, it is characterised in that the ferment
Mother is edible yeast, and the Lactobacillus helveticus is Lactobacillus helveticus Rosell-52, and the Lactobacillus rhamnosus is rhamnose breast
Bacillus Rosell-11, the bifidobacterium longum are bifidobacterium longum Rosell-175.
5. a kind of probiotic composition for being used to improve oral health according to any one of claims 1 to 4, its feature exist
In the composition is powdered.
6. a kind of probiotic composition for being used to improve oral health according to any one of claims 1 to 4, its feature exist
In, the composition using when reconstituted with water, for gargling, directly swallowed after stopping a period of time in the oral cavity.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN110051003A (en) * | 2019-04-24 | 2019-07-26 | 广州能靓生物技术有限公司 | A kind of compound probiotic composition and its application |
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| 佚名: "告别"口气"，实现可持续的口腔微生态平衡", 《HTTPS://MP.WEIXIN.QQ.COM/S?SRC=11&TIMESTAMP=1669707184&VER=4195&SIGNATURE=YB3HWTSGHPMXX9ZCH8*-DI6G38LS-WQSCC7KRY9DIAUSH5CFW04JSAFIF8VKVZJZVVM2QVJZJYAK6DNAGJHRIQU0QMTXDS4X1EOJ1TKSCRW0-Y5MEV8AJZONP8YWQGGJ&NEW=1》 * |
| 佚名: "益生菌2.0革命来了", 《 HENGT888.COM/DISPLAYNEWS.HTML-NEWSID=478961.HTM》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN109394822A (en) * | 2018-12-12 | 2019-03-01 | 广州普维君健药业有限公司 | Mouth disease composition and preparation method and application are alleviated in prevention |
| CN110051003A (en) * | 2019-04-24 | 2019-07-26 | 广州能靓生物技术有限公司 | A kind of compound probiotic composition and its application |
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