CN110051003A - A kind of compound probiotic composition and its application - Google Patents

A kind of compound probiotic composition and its application Download PDF

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Publication number
CN110051003A
CN110051003A CN201910333490.XA CN201910333490A CN110051003A CN 110051003 A CN110051003 A CN 110051003A CN 201910333490 A CN201910333490 A CN 201910333490A CN 110051003 A CN110051003 A CN 110051003A
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lactobacillus
probiotics
probiotic composition
weight
parts
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郭兆锋
刘小青
吴雪晴
郑政东
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Guangzhou Able Biotechnology Co Ltd
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Guangzhou Able Biotechnology Co Ltd
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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
    • A23G1/00—Cocoa; Cocoa products, e.g. chocolate; Substitutes therefor
    • A23G1/30—Cocoa products, e.g. chocolate; Substitutes therefor
    • A23G1/32—Cocoa products, e.g. chocolate; Substitutes therefor characterised by the composition containing organic or inorganic compounds
    • A23G1/40—Cocoa products, e.g. chocolate; Substitutes therefor characterised by the composition containing organic or inorganic compounds characterised by the carbohydrates used, e.g. polysaccharides
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
    • A23G1/00—Cocoa; Cocoa products, e.g. chocolate; Substitutes therefor
    • A23G1/30—Cocoa products, e.g. chocolate; Substitutes therefor
    • A23G1/32—Cocoa products, e.g. chocolate; Substitutes therefor characterised by the composition containing organic or inorganic compounds
    • A23G1/42—Cocoa products, e.g. chocolate; Substitutes therefor characterised by the composition containing organic or inorganic compounds containing microorganisms or enzymes; containing paramedical or dietetical agents, e.g. vitamins
    • A23G1/423—Cocoa products, e.g. chocolate; Substitutes therefor characterised by the composition containing organic or inorganic compounds containing microorganisms or enzymes; containing paramedical or dietetical agents, e.g. vitamins containing microorganisms, enzymes
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
    • A23L2/385—Concentrates of non-alcoholic beverages
    • A23L2/39—Dry compositions
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/125—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives containing carbohydrate syrups; containing sugars; containing sugar alcohols; containing starch hydrolysates
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/135—Bacteria or derivatives thereof, e.g. probiotics
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/14—Yeasts or derivatives thereof
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2400/00—Lactic or propionic acid bacteria
    • A23V2400/11—Lactobacillus
    • A23V2400/147—Helveticus
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2400/00—Lactic or propionic acid bacteria
    • A23V2400/11—Lactobacillus
    • A23V2400/169—Plantarum
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2400/00—Lactic or propionic acid bacteria
    • A23V2400/11—Lactobacillus
    • A23V2400/173—Reuteri
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2400/00—Lactic or propionic acid bacteria
    • A23V2400/11—Lactobacillus
    • A23V2400/175—Rhamnosus
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2400/00—Lactic or propionic acid bacteria
    • A23V2400/11—Lactobacillus
    • A23V2400/181—Salivarius
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2400/00—Lactic or propionic acid bacteria
    • A23V2400/51—Bifidobacterium
    • A23V2400/515—Animalis
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2400/00—Lactic or propionic acid bacteria
    • A23V2400/51—Bifidobacterium
    • A23V2400/517—Bifidum
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2400/00—Lactic or propionic acid bacteria
    • A23V2400/51—Bifidobacterium
    • A23V2400/529—Infantis
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2400/00—Lactic or propionic acid bacteria
    • A23V2400/51—Bifidobacterium
    • A23V2400/533—Longum

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Nutrition Science (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Inorganic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)

Abstract

The present invention relates to functional food technical field, a kind of compound probiotic composition and its application are disclosed.Probiotics compound of the present invention includes bacillary 1~25 parts by weight of probiotics, 20~70 parts by weight of 1~15 parts by weight of yeast probiotics and prebiotics.Probiotics compound of the present invention can be effectively colonized in oral cavity and enteron aisle, adjust the bacterial micro-ecological in oral cavity and enteron aisle, play antibacterial and anti-inflammatory effect, improve since a variety of oral cavities caused by flora is unbalance do not accommodate enteron aisle malaise symptoms, it solves the health status of oral cavity and enteron aisle simultaneously, can be used for preparing improvement, prevents and treats in the product of oral cavity or enteron aisle discomfort.

Description

A kind of compound probiotic composition and its application
Technical field
The present invention relates to functional food technical fields, and in particular to a kind of compound probiotic composition and its application.
Background technique
The mankind are just destined to coexist all one's life with microorganism from that quarter of being born, these microorganisms are one big just as human body Organ, they normally whether determine the health status of people.Enteron aisle is the maximum microbial habitats of human body, is one complicated Synthesis ecosystem.Both the digestion and absorption effect that carry food, moisture, also possesses intestinal tract immune system, defence harmful substance, Virus, pathogenic bacteria carry nerve and signal communication activity in addition, being also dispersed with more than one hundred million a nerve cells.
After we are by pathogenic infection, the beneficial bacterium of enteron aisle and the balance of harmful bacteria are broken, when harmful bacteria becomes excellent Gesture status, just produces disease.Probiotics is adjustable colony balance, to solve disease problems.
The common malaise symptoms of enteron aisle have constipation, diarrhea, abdominal pain, flatulence, vomiting etc..The Common drugs treatment side of constipation Case is enema, and care plans are to be dehydrated diarrhea ingredient using lotus leaf, folium sennae etc., in recent years dietary fiber and probiotics also by Gradually rise.Diarrhea usually only therapeutic scheme, such as montmorillonite powder.For the above drug therapy, often side effect is larger, controls It treats diarrhea and is easy to appear constipation, treatment constipation is easy to happen diarrhea again, and dosage is difficult to accurately control.For often occur constipation, The crowd of the enteron aisles malaise symptoms such as diarrhea, abdominal pain is especially uncomfortable with upper type, and drug etc. is used for a long time and influences whether itself instead The normalization of function of intestinal canal is easy to develop towards direction that is passive, deteriorating.
Oral cavity is human body link external environment and internal gastral place, is the second largest micro- life of human body for being only second to enteron aisle Object habitat, there are about 700 multiple-microorganisms, most of field planting is in tongue, and there are also on saliva, epithelial cell, tooth etc..Oral cavity It is human vas and neural most intensive place, is directly connected to blood circulation.Current research have been found that oral problem with Multiple systems are substantially closely related, such as periodontosis, cardiovascular disease, respiratory disease, diabetes, hypertension, lung Disease, the nervous system disease etc..
The most important mouth disease in the whole world is saprodontia and periodontosis, and in addition there are halitosis, candidiasis etc..Oral cavity flora Change is the main reason for the above oral problem occurs, and probiotics can promote the well balanced of the bacterium of oral health, thus Prevent mouth infection.Saprodontia is a kind of bacteriosis, in the effect of the bacteriums such as streptococcus mutans, remote source streptococcus, actinomyces Under, oral cavity organic acid increases, and pH is reduced, enamel decalcification, and destruction of organic material, forms cavity；Can also destruction of organic material, formed Cavity.The illness rate of Chinese children saprodontia is up to 90% or more, and concern and prevention children caries problem are extremely urgent.Periodontosis point For gingivitis and periodontitis, main pathogenic is also bacterium.Plaque is the initiation factor of periodontosis, is the master of periodontosis Want pathogenic factor.The accumulation of plaque can evolve into periodontitis.Cause gingivitis pathogenic bacteria be mainly porphyromonas gingivalis, Bacterium actinomycetem comitans etc., and the candida albicans of biomembrane can be formed.The people in China about 85% has periodontal problems, most numbers be 12 years old with Lower children, there are also adults and old man.Smoking is the important risk factor of periodontosis, and China is just the largest smoking country. The pathogenic bacteria such as Prevotella intermedia, Fu Shi bacteroid, treponema denticola of the halitosis 90% in oral cavity produce odorous gas Or volatile sulfur compounds.The illness rate of Chinese's halitosis is differed 22% to 50% or more.Halitosis is often ignored by people, so tight It will affect normal interpersonal, emotion communication when weight, make us very worried.
Oral cavity and enteron aisle still can be solved the problems, such as simultaneously without a kind of nutrient and healthcare products at present.Saprodontia, tooth for oral cavity The problems such as week or halitosis, generallys use the mode of drug sterilization processing, in addition, toothpaste and mouthwash are most common oral cares Mode.Drug therapy is divided into oral local administration and systemic administration, and local application is handled with dentist, relatively cumbersome, takes orally anti- Raw element all has an impact to the microorganism in oral cavity and whole body, and the balance of whole body flora is also destroyed while treating illness.And Toothpaste is typically only capable to play the role of daily maintenance, has very big relationship with personal hygiene habit and brushing action, aquatic products of gargling Product can play antibacterial effect, but also destroy oral microorganism balance simultaneously.
Oral cavity and gastrointestinal tract are linked by upper digestive tract, and Oral health behaviours are also closely coupled with intestinal microecology.Pass through Check that the microorganism group in oral cavity can also reflect the health problem of enteron aisle at variation, conversely, the function status of enteron aisle can cause oral cavity Illness.Our oral cavity and enteron aisle not only have the transmission of food, more have transmission between microorganism with exchange.Pass through micro- life The approach of object solves the relevant issues in oral cavity and enteron aisle, is novel a big promising trial and invention.
Summary of the invention
In view of this, mouth can be improved simultaneously the purpose of the present invention is to provide a kind of compound probiotic composition The bacterial micro-ecological of chamber and enteron aisle inhibits pathogenic flora, improves oral cavity and enteron aisle malaise symptoms, and can be applied to preparation improvement mouth In chamber and/or the health care product of enteron aisle discomfort.
To achieve the goals above, the invention provides the following technical scheme:
A kind of compound probiotic composition, comprising:
Bacillary 1~25 parts by weight of probiotics；
1~15 parts by weight of yeast probiotics；
20~70 parts by weight of prebiotics.
Preferably, the probiotic composition includes:
Bacillary 5~20 parts by weight of probiotics；
3~10 parts by weight of yeast probiotics；
40~65 parts by weight of prebiotics.
From oral cavity to enteron aisle, bacterium+saccharomycete+prebiotics technical solution provided by the invention, can coordinate two kinds Effect between microorganism, at the same by prebiotics supporting function, can simultaneously relief of caries, periodontosis, halitosis, avoid, abdomen It rushes down, oral cavities and the enteron aisle malaise symptoms such as abdominal pain.
In the specific embodiment of the invention, the parts by weight of the bacillary probiotics be 7 parts, 12 parts, 13 parts or 13.3 parts；The parts by weight of the yeast probiotics are 4 parts, 5 parts, 6 parts or 10 parts；The parts by weight of the prebiotics are 20 Part, 21 parts, 22 parts, 24 parts, 35 parts, 54 parts, 56 parts or 70 parts；
In the specific embodiment of the invention, the yeast probiotics is selected from Bu Ladi saccharomycete, also referred to as cloth Laplace yeast Bacterium, Classification system are Saccharomyces cerevisiae var boulardii (S.boulardii).
Bu Ladi yeast in the present invention is multiple by antibacterial action, antitoxin effect, barrier action, immunoregulation effect Mechanism protects intestinal health.
Specifically, first, the antibacterial action of Bu Ladi yeast is embodied in its epicyte and enterocyte surface layer phase Seemingly, as the pathogens such as enteropathogenic E. Coli can be directly adhered to Bu Ladi yeast cell surface, rather than enterocyte, so They are excreted with excrement afterwards, moreover it is possible to the directly growth of the human bodies harmful bacteria such as inhibition Candida albicans.
Second, Bu Ladi yeast makes Clostridium difficile toxin A, cholera toxin, Escherichia coli by discharging specific albumen The inactivation such as toxin, and the receptor of these toxin is dissolved, it is common to play antitoxin effect.During bacterium infection, MLC albumen is by phosphorus Acidification, interrupts intercellular tight junction, pathogen is shifted, and Bu Ladi yeast can inhibit MLC phosphorylation, to protect The close connection of enterocyte, reduces the infiltration and displacement of pathogen.
Third, Bu Ladi yeast also participates in metabolism, nutrition, the absorption of glucose are improved, increases short-chain fat sour water Flat, recovery enteron aisle normally ferments and absorption activity.
Fourth, Bu Ladi yeast can also promote the proliferation of Bacillus acidi lactici and Bifidobacterium, inhibit the growth of harmful bacteria, Bradley Enlightening yeast can help restorative microbial flora, provide additional protection for the rete malpighii and mucous membrane of host.
Fifth, Bu Ladi yeast can lower the expression of inflammation gene expression, anti-inflammatory effect is played.Finally, Bu Ladi yeast can pierce The secretion for swashing the immune factors such as IgA, stimulates the activity of immunocyte.
Preferably, the bacillary probiotics includes Bifidobacterium and/or Lactobacillus.Of the invention specific real It applies in mode, the bacillary probiotics includes Bifidobacterium and Lactobacillus simultaneously, and the two is respectively selected from a kind of or more The kind microorganism belonging to genus.More specifically, the Bifidobacterium be selected from bifidobacterium longum, bifidobacterium breve, animal bifidobacteria, One or more of bifidobacterium infantis, bifidobacterium bifidum, bifidobacterium adolescentis；The Lactobacillus is selected from auspicious Scholar's lactobacillus, Lactobacillus rhamnosus, lactobacillus acidophilus, lactobacillus plantarum, Lactobacillus casei, lactobacillus paracasei, Luo Yishi cream One or more of bacillus, Lactobacillus salivarius, lactobacillus fermenti, lactobacillus gasseri.
One of in the specific embodiment of the invention, the Bifidobacterium and Lactobacillus selection are following:
(1) animal bifidobacteria, bifidobacterium infantis, Lactobacillus helveticus and Lactobacillus rhamnosus；
(2) bifidobacterium longum, lactobacillus plantarum and Lactobacillus helveticus；
(3) bifidobacterium bifidum, animal bifidobacteria, Lactobacillus helveticus and Lactobacillus rhamnosus；
(4) bifidobacterium longum, Lactobacillus rhamnosus, Lactobacillus salivarius and Lactobacillus helveticus；
(5) lactobacillus acidophilus, lactobacillus reuteri and animal bifidobacteria；
The weight ratio of the Bifidobacterium and Lactobacillus be (1-5): (5-10), specifically, Bifidobacterium and The weight ratio of Lactobacillus is 4.3:9,2:5,4:8 (1:2), 5:8 or 2:5.
In the present invention, Bu Ladi saccharomycete is a kind of unique probiotics of yeast sources, can be mentioned for enteric microorganism Slime layer and mucous membrane for good growing environment, and for human body provide additional protection.Yeast and the mechanism of action of bacterium are not Together, two class probiotics collective effect, realizes the probiotic effects to make the best of both worlds.
Specifically, bacterium belongs to prokaryotes, and yeast belongs to eucaryote cell wall and nuclear structures；Bacterium It is proliferated by cell division, and yeast is budding mode；Bacterium accounts for the 99% of microbe colony, and yeast is accounted for less than 1%；Bacterium pair Antibiotic sensitive, and yeast is insensitive to antibiotic, it is sensitive to antifungal agent.The cell wall of saccharomyces cerevisiae has very important Physiological action accounts for the 40% of entire yeast cells, is mainly made of beta glucan and manna oligosacchride chain.Both ingredients both right and wrong Often good prebiotic component, and the ingredient of the very burning hot raising immunity of research at present, have high health value.
For from mechanism of action, functioning as Bu Ladi yeast is first layer defence, and bacillary probiotics Functioning as is second layer defence.
Bacillary probiotics it is intracavitary by with pathogenic bacteria facedown, play eliminate potentially pathogenic organism, prevention pathogenic bacteria Adherency and generate toxin, and Bu Ladi yeast is taken it out in vitro by directly adhering to pathogenic bacteria, in addition, yeast cell wall Manna oligosacchride can also adhere to some gram negative pathogenic bacterias.
The important function mechanism that barrier action is probiotics is played on epithelial cell, bacterium can compete with pathogenic bacteria and seize Attachment sites, and the effect of Bu Ladi yeast is that information interchange is carried out with intestinal mucosa, the integrality of protective barrier rebuilds mucous membrane Metabolism can also strengthen intestinal flora.
Article 3 mechanism of action is immunoregulation effect, the specificity and nonspecific immune reaction of exciting human, this The mechanism of action of the good Bu Ladi yeast of aspect bacterium is similar, while Mannoproteins and beta glucan on yeast cell wall Immunoregulation effect can be played, 6000+ publication has investigated the immunoregulation effects such as the anti-inflammatory of yeast beta-dextran, antibacterial. In addition, Bu Ladi yeast also has another effect, the manna oligosacchride on yeast cell wall also has the function of prebiotics, to having Beneficial bacteria has good promotion cultivation effect.It is noted that bacillary probiotics only has competition or inhibition to pathogenic bacteria thallus Effect, but be not have influential on cytotoxin, and Bu Ladi yeast can be to anticytotoxin, such as Clostridium difficile toxin A B。
Preferably, the prebiotics are selected from inulin, polydextrose, oligofructose, galactooligosaccharide, xylo-oligosaccharide, water Soluble dietary fiber (such as resistant dextrin), stachyose, soyabean oligosaccharides, breast milk oligosaccharide, oligoisomaltose, different malt ketone One or more of sugar, trehalose, arabinose.
One of in the specific embodiment of the invention, the prebiotics selection is following:
(1) resistant dextrin, inulin and xylo-oligosaccharide；
(2) oligofructose and galactooligosaccharide；
(3) stachyose, oligoisomaltose and trehalose；
(4) soyabean oligosaccharides and polydextrose；
(5) breast milk oligosaccharide sugar, isomaltoketose and arabinose；
(6) resistant dextrin and inulin；
(7) inulin and xylo-oligosaccharide；
(8) xylo-oligosaccharide or inulin；
Preferably, the viable bacteria concentration of the probiotics is 104Cfu/g~1012cfu/g；Preferred 106Cfu/g~ 1011Cfu/g, further preferred 108Cfu/g~1010cfu/g。
The present invention choose 200 have oral problem (comprising saprodontia, fall tooth, halitosis, gum redness, stomatocace, The oral cavities malaise symptoms such as toothache) and bowel problems (include the enteron aisles such as habitual constipation, diarrhea, borborygmus, enterospasm, abdominal distension, abdominal pain Malaise symptoms) crowd be subjects, by take probiotic composition of the present invention and control probiotics come evaluate and test improve effect Fruit, the results show that take probiotic composition of the present invention crowd have lower dental plaque index and gingival index, while It is higher to improve page in the scoring of enteron aisle discomfort.Based on above-mentioned test result, the present invention provides the probiotic compositions to make Application in the standby product for adjusting oral health and intestinal health.
According to above-mentioned application, the present invention provides a kind of probiotic products for adjusting oral cavity and intestinal health, including this hair The bright probiotic composition.
Preferably, the probiotic products include the probiotic composition, and it is selected from oral health component, enteron aisle One or more of healthy component, vitamin, minerals, fruits and vegetables, glucide, filler and corrigent component.
Wherein, the probiotic composition, oral health component, intestinal health component, juice powder/slurry, glucide, Vitamin and mineral, filler, corrigent weight ratio be (40~95): (0~10): (0~40): (0~25): (0~ 40): (0~5): (0~20): (0~5).
Preferably, the oral health component includes turmeric, Cranberry, Honegsukle flower P.E；The intestinal health group Divide includes vegetables and fruits plant enzyme powder, compoiste fermented fruit vegetable powder；The vitamin includes vitamin D, vitamin B, vitamin C and richness Vitamin yeast；The minerals include calcium, magnesium, selenium and newborn mineral salt；The fruits and vegetables refer mainly to juice powder/slurry, Its fruits being well known to those skilled in the art, greengrocery or cereal class or the juice powder or slurry of plurality of raw materials mixing Powder；The glucide be selected from glucose, crystal diabetin, lactulose, xylitol, antierythrite, D-sorbite, mannitol, One of maltitol, lactitol are a variety of；Above-mentioned each substance may be selected one or more；
Preferably, the glucide needed 60~100 meshes, then it is dried at low temperature, control moisture exists 3% or less.The product requires strict temperature control at 20 ± 2 DEG C during the preparation process, and humidity is 30 ± 5%.
Preferably, the filler is in maltodextrin, starch, microcrystalline cellulose, magnesium stearate, silica It is one or more；The corrigent includes one of sweetener, acid and essence or a variety of.
Preferably, the product is solid beverage, capsule, gel candy, buccal tablets, tablet, dispersing agent, granule Or chocolate.
From the above technical scheme, probiotics compound of the present invention can be effectively colonized in oral cavity and enteron aisle, Adjust the bacterial micro-ecological in oral cavity and enteron aisle, play antibacterial and anti-inflammatory effect, improve due to flora it is unbalance caused by a variety of mouths Chamber does not accommodate enteron aisle malaise symptoms, while solving the health status of oral cavity and enteron aisle, can be used for preparing improvement, prevents and treats In the product of oral cavity or enteron aisle discomfort.
Detailed description of the invention
Fig. 1 show the dental plaque index of Examples 1 to 5 and the dental plaque index figure of comparative example 1-5；Wherein, a is to implement The dental plaque index figure of example 1-5, A cylindricality indicates 0 week as a result, B cylindricality indicates 4 weeks results；B is embodiment 1 and comparative example 1-5 Dental plaque index figure, A cylindricality indicates 0 week as a result, B cylindricality indicates 4 weeks results；
Fig. 2 show the gingival index of Examples 1 to 5 and the gingival index figure of comparative example 1-5；Wherein, a is embodiment 1- 5 gingival index figure, A cylindricality indicates 0 week as a result, B cylindricality indicates 4 weeks results；B refers to for the gum of embodiment 1 and comparative example 1-5 Number figure, A cylindricality indicates 0 week as a result, B cylindricality indicates 4 weeks results.
Specific embodiment
The invention discloses a kind of compound probiotic composition and its application, those skilled in the art can be used for reference in this paper Hold, is suitably modified realization of process parameters.In particular, it should be pointed out that all similar substitutions and modifications are to those skilled in the art For be it will be apparent that they are considered as being included in the present invention.Probiotic composition of the present invention and its application are through logical Preferred embodiment is crossed to be described, related personnel obviously can not depart from the content of present invention, in spirit and scope to this paper institute The probiotic composition stated and its application is modified or appropriate changes and combinations, carrys out implementation and application the technology of the present invention.
The characteristic and effect of probiotics have strain specificity, should not rest on the level of strain, it is necessary to establish in bacterial strain The invention and research done on the basis of number are just significant, and it is indefinite often to there is probiotics strain in current invention Problem.Therefore the present invention has selected some specific bacterial strains in a specific embodiment, it is as follows:
Cloth Lardy yeast CNCM-I-1019, Lactobacillus helveticus Rosell-52, lactobacillus acidophilus Rosell-418, Luo Yishi Lactobacillus HA-188, it Lactobacillus salivarius HA-118, lactobacillus plantarum Rosell-1012, Lactobacillus rhamnosus Rosell-11, moves Object Bifidobacterium LAFTI B94, bifidobacterium infantis HA-116, bifidobacterium longum Rosell-175, bifidobacterium bifidum Rosell-71；
Just a kind of compound probiotic composition provided by the present invention and its application are described further below.
Embodiment 1:
A kind of probiotics solid beverage with dual regulation oral cavity and intestinal health, by the raw material group of following parts by weight At:
Preparation method: 20 ± 2 DEG C of environment temperature are controlled when material metage and production, relative humidity 30%-35%.When mixing First probiotic powder (Bu Ladi yeast CNCM-I-1019, Lactobacillus helveticus Rosell-52, Lactobacillus rhamnosus Rosell-11, Animal bifidobacteria LAFTI B94, bifidobacterium infantis HA-116) it is uniformly mixed, then it is (resistant dextrin, inulin, low with prebiotics Xylan), fruit powder (strawberry juice powder), corrigent (strawberry essence, Sucralose) by gradient be uniformly mixed.It is packaged into 2g/ packet, out Factory's viable bacteria concentration is not less than 1 × 1010The probiotics solid beverage of cfu/g.
It is buccal to be dissolved in a small amount of warm water (40 DEG C or less), is please taken immediately after opening, it is proposed that takes before the meal or with meal daily, often Secondary 1 packet, daily 1~2 time.
Embodiment 2:
The molten type probiotics solid beverage of a kind of mouth with dual regulation oral cavity and intestinal health, by the original of following parts by weight Material composition:
Preparation method: by sugar alcohol (antierythrite, xylitol) 80 meshes excessively, then drying to moisture content is at low temperature 3% or less.20 ± 2 DEG C of environment temperature are controlled when weighing and production, relative humidity 30%-35%.First probiotic powder when mixing (Bu Ladi yeast CNCM-I-1019, Lactobacillus helveticus Rosell-52, lactobacillus plantarum Rosell-1012, bifidobacterium longum Rosell-175) be uniformly mixed, then with prebiotics (oligofructose, galactooligosaccharide), fruit powder (green cumquat juice powder), filler (cornstarch) is uniformly mixed by gradient, is finally uniformly mixed again with sugar alcohol.Be packaged into 2g/ packet, factory viable count not less than 6 × 109The probiotics solid beverage of cfu/g.
Direct mouth is molten or to be dissolved in a small amount of warm water (40 DEG C or less) buccal, please takes immediately after opening, it is proposed that it is daily before the meal or It is taken with meal, every time 1 packet, daily 1~2 time.
Embodiment 3:
A kind of probiotics solid beverage with dual regulation oral cavity and intestinal health, by the raw material group of following parts by weight At:
Preparation method: crossing 80 meshes for sugar alcohol (antierythrite, maltitol), is then dried at low temperature to moisture content It is 3% or less.20 ± 2 DEG C of environment temperature are controlled when weighing and production, relative humidity 30%-35%.First probiotics when mixing Powder (Bu Ladi yeast CNCM-I-1019, Lactobacillus rhamnosus Rosell-343, Lactobacillus helveticus LAFTI L10, not tally bifid Bacillus Rosell-71) be uniformly mixed, then with prebiotics (stachyose, oligoisomaltose, trehalose), fruit powder (lemon juice powder), Filler (cornstarch) is uniformly mixed by gradient, is finally uniformly mixed again with sugar alcohol.It is packaged into 2g/ packet, factory viable count is not Less than 1.5 × 1010The probiotics solid beverage of cfu/g.
Direct mouth is molten or to be dissolved in a small amount of warm water (40 DEG C or less) buccal, please takes immediately after opening, it is proposed that it is daily before the meal or It is taken with meal, every time 1 packet, daily 1~2 time.
Embodiment 4:
A kind of probiotics solid beverage with dual regulation oral cavity and intestinal health, by the raw material group of following parts by weight At:
Preparation method: by sugar alcohol (antierythrite, xylitol) 80 meshes excessively, then drying to moisture content is at low temperature 3% or less.20 ± 2 DEG C of environment temperature are controlled when weighing and production, relative humidity 30%-35%.First probiotic powder when mixing (Bu Ladi yeast CNCM-I-1019, Lactobacillus rhamnosus Rosell-11, Lactobacillus salivarius HA-118, Lactobacillus helveticus LAFTI L10, bifidobacterium longum Rosell-175) be uniformly mixed, then with prebiotics (soyabean oligosaccharides, polydextrose), fruit powder (pineapple juice Powder), filler (cornstarch) by gradient be uniformly mixed, finally again with sugar alcohol be uniformly mixed.It is packaged into 2g/ packet, viable bacteria of dispatching from the factory Number is not less than 1.2 × 1010The probiotics solid beverage of cfu/g.
Direct mouth is molten or to be dissolved in a small amount of warm water (40 DEG C or less) buccal, please takes immediately after opening, it is proposed that it is daily before the meal or It is taken with meal, every time 1 packet, daily 1~2 time.
Embodiment 5:
A kind of probiotics solid beverage with dual regulation oral cavity and intestinal health, by the raw material group of following parts by weight At:
Preparation method: by sugar alcohol (antierythrite, xylitol) 80 meshes excessively, then drying to moisture content is at low temperature 3% or less.20 ± 2 DEG C of environment temperature are controlled when weighing and production, relative humidity 30%-35%.First probiotic powder when mixing (Bu Ladi yeast CNCM-I-1019, lactobacillus acidophilus Rosell-418, lactobacillus reuteri HA-188, animal bifidobacteria LAFTI B94) it is uniformly mixed, then (yellow peach is lyophilized with prebiotics (breast milk oligosaccharide sugar, isomaltoketose, arabinose), fruit powder Point powder), vegetables and fruits plant enzyme powder, filler (cornstarch) be uniformly mixed by gradient, be finally uniformly mixed again with sugar alcohol.Packaging At 2g/ packet, the viable count that dispatches from the factory is not less than 2 × 1010The probiotics solid beverage of cfu/g.
Direct mouth is molten or to be dissolved in a small amount of warm water (40 DEG C or less) buccal, please takes immediately after opening, it is proposed that it is daily before the meal or It is taken with meal, every time 1 packet, daily 1~2 time.
Embodiment 6:
A kind of probiotics buccal tablets with dual regulation oral cavity and intestinal health, by the raw material group of following parts by weight At:
Preparation method: material metage and production process are both needed to 20 ± 2 DEG C of environment temperature of control, relative humidity 30%-35%. First probiotic powder (Bu Ladi yeast CNCM-I-1019, Lactobacillus helveticus Rosell-52, Lactobacillus rhamnosus when mixing Rosell-11, animal bifidobacteria LAFTI B94, bifidobacterium infantis HA-116) it is uniformly mixed；Again by prebiotics (oligomeric wood Sugar), xylitol, frozen dried sour milk powder, calcium gluconate, microcrystalline cellulose, cornstarch, magnesium stearate by gradient be uniformly mixed, Wet granulation crosses 40 meshes；Bacterium powder and particle are uniformly mixed and are made 0.6g/ piece with rotary tablet machine, hardness control 40~ 50N is preferable, and bottling is sealed to obtain the final product, and factory viable bacteria concentration is not less than 2 × 109Cfu/ piece.
Buccal tablets, probiotic milk tablets, it is proposed that it takes before the meal or with meal daily, 2 tablets once, and daily 1~2 time.
Embodiment 7:
A kind of probiotics buccal tablets with dual regulation oral cavity and intestinal health, by the raw material group of following parts by weight At:
Preparation method: material metage and production process are both needed to 20 ± 2 DEG C of environment temperature of control, relative humidity 30%-35%. First probiotic powder (Bu Ladi yeast CNCM-I-1019, Lactobacillus helveticus Rosell-52, Lactobacillus rhamnosus when mixing Rosell-11, animal bifidobacteria LAFTI B94, bifidobacterium infantis HA-116) it is uniformly mixed；Again by prebiotics (oligomeric wood Sugar), xylitol, Honegsukle flower P.E, Fructus Momordicae fructoside, menthol, microcrystalline cellulose, cornstarch, magnesium stearate press gradient It is uniformly mixed, wet granulation crosses 40 meshes；Bacterium powder and particle are uniformly mixed, 1g/ piece, hardness control is made with rotary tablet machine System is preferable in 40~50N, and bottling is sealed to obtain the final product, and factory viable bacteria concentration is not less than 4 × 109Cfu/ piece.
Buccal tablets, it is proposed that take before the meal or with meal daily, 1~2 every time, daily 1~2 time.
Embodiment 8:
A kind of probiotics discrete particles with dual regulation oral cavity and intestinal health, by the raw material group of following parts by weight At:
Preparation method: 20 ± 2 DEG C of environment temperature are controlled when material metage and production, relative humidity 30%-35%.When mixing First probiotic powder (Bu Ladi yeast CNCM-I-1019, Lactobacillus helveticus Rosell-52, Lactobacillus rhamnosus Rosell-11, Animal bifidobacteria LAFTI B94, bifidobacterium infantis HA-116) be uniformly mixed, then by prebiotics (resistant dextrin, inulin), Fruit powder (Cranberry fruit powder), xylitol, antierythrite, guar gum, silica are uniformly mixed.Wet granulation crosses 10 meshes, warp Dry, whole grain adds bacterium powder by gradient is uniformly mixed and is distributed into 2g/ packet, and factory viable bacteria concentration is not less than 1 × 1010Cfu/g's Probiotics discrete particles.
Direct mouth is molten or to be dissolved in a small amount of warm water edible, it is proposed that takes, 1 wraps every time, daily 1~2 time before the meal or with meal daily.
Embodiment 9:
A kind of probiotics chocolate with dual regulation oral cavity and intestinal health, is made of the raw material of following parts by weight:
Preparation method: 20 ± 2 DEG C of environment temperature are controlled when material metage and production, relative humidity 30%-35%.When mixing First probiotic powder (Bu Ladi yeast CNCM-I-1019, Lactobacillus helveticus Rosell-52, Lactobacillus rhamnosus Rosell-11, Animal bifidobacteria LAFTI B94, bifidobacterium infantis HA-116) it is uniformly mixed；Again with prebiotics (inulin), cocoa liquor, White granulated sugar, cocoa butter, whole milk powder, lecithin are fully ground at room temperature, and chocolate mass, gradient are refined at 45~50 DEG C When being cooled to 30 DEG C, probiotics bacterial powder is added and stirs, moulding is placed in 10 DEG C of environment cooling 30min, demoulds, dress For bottle closure up to 0.6g/, factory viable bacteria concentration is not less than 1 × 109The probiotics marble chocolate of cfu/g.
Clothes are chewed in mouth containing, and bottle cap please be tightened after use, it is proposed that it takes before the meal or with meal daily, 2 tablets each time, daily 1~2 time.
Embodiment 10:
A kind of probiotics capsule with dual regulation oral cavity and intestinal health, is made of the raw material of following parts by weight:
Preparation method: 20 ± 2 DEG C of environment temperature are controlled when material metage and production, relative humidity 30%-35%.When mixing First probiotic powder (Bu Ladi yeast CNCM-I-1019, Lactobacillus helveticus Rosell-52, Lactobacillus rhamnosus Rosell-11, Animal bifidobacteria LAFTI B94, bifidobacterium infantis HA-116) it is uniformly mixed；By prebiotics (inulin, xylo-oligosaccharide), ginger Yellow, cornstarch is uniformly mixed；Probiotic powder is added by gradient again to be uniformly mixed, pours the mixture into the automatic filler of capsule Up to 0.5g/, factory viable bacteria concentration is not less than 2.5 × 109The probiotics capsule of cfu/g.
A small amount of warm water is swallowed, it is proposed that it takes before the meal or with meal daily, 2 tablets each time, daily 1~2 time.
Embodiment 11: comparative test
The comparative example of different compositions and ratio is set based on embodiment 1, and the bacterium part of missing is replaced with maltodextrin, matched Side such as the following table 1:
Table 1
Preparation method and eating method are the same as embodiment 1.
Comparative test
It chooses 200 7~60 years old ages while there is oral problem (comprising saprodontia, to fall tooth, halitosis, gum redness, oral cavity The oral cavities such as mucosa ulcer, toothache malaise symptoms) and bowel problems (comprising habitual constipation, diarrhea, borborygmus, enterospasm, abdominal distension, The enteron aisles such as abdominal pain malaise symptoms) crowd be subjects, average age 35 ± 7.37 years old.It is randomly divided into 10 groups, every group of 20 people, The product taken is Examples 1 to 5, and comparative example 1~5,1 time a day, 1 packet, is dissolved in mouth containing 1min posterior phraynx in 20ml warm water every time Under, it continuously takes 4 weeks.
Evaluation criterion: oral health is indicated that intestinal health improves situation by symptom by dental plaque index and dental plaque index It indicates, it is separately sampled before and after the test, it is averaged.
Dental plaque index evaluation criterion:
0 degree: without bacterial plaque；
1 degree: bacterial plaque is located at neck portion, in scattered spot distribution；
2 degree: bacterial plaque is located at neck portion, linear, width 1mm；
3 degree: bacterial plaque width G T.GT.GT 1mm, but not up to corona 1/3；
4 degree: the width of bacterial plaque reaches the 1/3 of corona, but not up to corona 2/3；
5 degree: the width of bacterial plaque reaches 2/3 of corona or more.
Gingival index evaluation criterion:
0=gums healthy；
1=gum mild inflammation: the color of gum has mild change and Mild edema, and not bleeding is examined in spy；
2=gum moderate inflammation: gum color is red, and oedema is bright, and bleeding is examined in spy；
3=gum extensive inflammation: gum is obvious red and swollen or has ulcer, and has automatic hemorrhagic tendency.
Bowel problems symptom improves situation evaluation criterion:
0=is without significant change；
1=slightly improves or part improves
2=is significantly improved；
3=recovery from illness；
Test result:
The plaque of dental plaque index test result such as Fig. 1 (a) of Examples 1 to 5, embodiment 1 and the Comparative Examples 1 to 5 refers to Number test result such as Fig. 1 (b)；
The gingival index of gingival index test result such as Fig. 2 (a) of Examples 1 to 5, embodiment 1 and the Comparative Examples 1 to 5 is surveyed Test result such as Fig. 2 (b)；
It can be seen that according to the result of Fig. 1 and Fig. 2 and take probiotic composition dental plaque index of the present invention and gingival index It is lower, show that probiotic composition of the present invention can preferably improve oral health；
The bowel symptoms of Examples 1 to 5 improve situation, and test result is as follows shown in table 2:
Table 2
Recovery from illness/people Significantly improve/people Slight improvement/people Unchanged/people Score
Embodiment 1 8 1 1 0 27
Embodiment 2 4 3 3 0 21
Embodiment 3 6 2 2 0 24
Embodiment 4 5 3 2 0 23
Embodiment 5 6 3 1 0 25
Comparative example 1 3 3 4 0 19
Comparative example 2 3 2 3 2 16
Comparative example 3 3 2 4 1 17
Comparative example 4 2 1 5 2 13
Comparative example 5 0 1 1 8 3
Score=3* recovery from illness number+2* significantly improves number+1*, and slightly improvement+0* is unchanged；Full marks 30 divide.
According to the result of table 2 it is found that taking probiotic composition bowel symptoms of the present invention improves situation more preferably.
The above is only a preferred embodiment of the present invention, it is noted that for the ordinary skill people of the art For member, various improvements and modifications may be made without departing from the principle of the present invention, these improvements and modifications are also answered It is considered as protection scope of the present invention.

Claims (14)

1. a kind of compound probiotic composition characterized by comprising
Bacillary 1~25 parts by weight of probiotics；
1~15 parts by weight of yeast probiotics；
20~70 parts by weight of prebiotics.
2. probiotic composition according to claim 1 characterized by comprising
Bacillary 5~20 parts by weight of probiotics；
3~10 parts by weight of yeast probiotics；
40~65 parts by weight of prebiotics.
3. probiotic composition according to claim 1 or claim 2, which is characterized in that the bacillary probiotics includes bifid bar Pseudomonas and/or Lactobacillus.
4. probiotic composition according to claim 3, which is characterized in that the Bifidobacterium be selected from bifidobacterium longum, One or both of bifidobacterium breve, animal bifidobacteria, bifidobacterium infantis, bifidobacterium bifidum, bifidobacterium adolescentis More than.
5. probiotic composition according to claim 3, which is characterized in that the Lactobacillus be selected from Lactobacillus helveticus, Lactobacillus rhamnosus, lactobacillus acidophilus, lactobacillus plantarum, Lactobacillus casei, lactobacillus paracasei, lactobacillus reuteri, saliva One or more of lactobacillus, lactobacillus fermenti, lactobacillus gasseri.
6. probiotic composition according to claim 3, which is characterized in that the weight of the Bifidobacterium and Lactobacillus Amount is than being (1-5): (5-10).
7. probiotic composition according to claim 1 or claim 2, which is characterized in that the yeast probiotics is Bu Ladi yeast Bacterium.
8. probiotic composition according to claim 1 or claim 2, which is characterized in that the prebiotics are selected from inulin, poly- grape Sugar, oligofructose, galactooligosaccharide, xylo-oligosaccharide, water-soluble dietary fiber, stachyose, soyabean oligosaccharides, breast milk oligosaccharide, One or more of oligoisomaltose, isomaltoketose, trehalose, arabinose.
9. probiotic composition according to claim 1 or claim 2, which is characterized in that the viable bacteria concentration of the probiotics is 104Cfu/g~1012cfu/g。
10. the product that probiotic composition described in claim 1-9 any one adjusts oral health and intestinal health in preparation In application.
11. a kind of probiotic products for adjusting oral cavity and intestinal health, which is characterized in that including claim 1-9 any one The probiotic composition.
12. probiotic products according to claim 11, which is characterized in that including benefit described in claim 1-10 any one Raw bacteria composition, and it is selected from oral health component, intestinal health component, vitamin, minerals, fruits and vegetables, glucide, filling One or more of agent and corrigent component.
13. probiotic products according to claim 12, which is characterized in that the probiotic composition, oral health component, Intestinal health component, juice powder/slurry, glucide, vitamin and mineral, filler, corrigent weight ratio be (40~ 95): (0~10): (0~40): (0~25): (0~40): (0~5): (0~20): (0~5).
14. probiotic products according to claim 11, which is characterized in that the product is solid beverage, capsule, gel sugar Fruit, buccal tablets, tablet, dispersing agent, granule or chocolate.
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Application publication date: 20190726