CN110200824A

CN110200824A - A kind of sugar-free toothpaste and its production method containing resveratrol

Info

Publication number: CN110200824A
Application number: CN201910540232.9A
Authority: CN
Inventors: 王芯茹
Original assignee: Jiangsu Yuandan Life Technology Co Ltd
Current assignee: Jiangsu Yuandan Life Technology Co Ltd
Priority date: 2019-06-21
Filing date: 2019-06-21
Publication date: 2019-09-06

Abstract

A kind of sugar-free toothpaste and its production method containing resveratrol, is related to toothpaste production technical field.First resveratrol, sitosterol, antierythrite, glycerol, steviol glycoside and sodium bicarbonate are dissolved in deionized water, obtain mixed solution；Again by after mixed solution, surfactant, rubbing agent, gelling agent, anti-allergic agent, fruity flavor and brightening agent homogeneous, the sugar-free toothpaste containing resveratrol is obtained.This method keeps property of raw material without chemical change；Reinforce the interaction between each substance under vacuum negative pressure condition, each raw material is sufficiently mixed uniformly；Whole process is easy to operate, mild condition, no waste, and energy-saving and emission-reduction are environmentally protective.The toothpaste of acquirement has good bactericidal antiphlogistic effect, and oral bacteria is inhibited to breed, and inhibits plaque, keeps breath freshening, reduces bleeding gums, Sprouting resistance disease effect.

Description

A kind of sugar-free toothpaste and its production method containing resveratrol

Technical field

The present invention relates to toothpaste production technical fields.

Technical background

With the raising of people's lives level, oral health issue be also increasingly be concerned by people again, wherein Toothpaste is to solve oral problem, safeguards the important nursing materials of oral hygiene, so toothpaste and people's daily life cease manner of breathing It closes.In recent years people step up oral cavity health care consciousness, however the generation of China's mouth disease problem especially dental caries, plaque And the illness rate of periodontal disease is still very high, and plaque is the sanctuary of oral microorganism, it is constantly gathered in oral cavity, until Mineralising forms dental calculus (also referred to as tartar), and leads to the relevant gum disease of plaque.Correctly select the toothpaste of corresponding effect can To prevent and mitigate the mouth diseases such as dental caries, periodontal disease, the oral health of people is improved, while also economizing on resources for society.

In correlative study investigation, it can solve dental problems in toothpaste and be mainly anti-caries effect, plaque is inhibited to mitigate Gingivitis effect mitigates five large effects of the effect of the effect of dentine hypersensitivity, Sprouting resistance disease effect, protection mucous membrane of mouth, but It is not many for reaching the toothpaste species of the effect simultaneously.Some effects only up to breath freshening of traditional toothpaste, Huo Zhedan One effect, dental health problems are unable to complete treatment.

Resveratrol is a kind of polyphenolic substance of non-flavonoids, and resveratrol is widely present in seed plant, belongs to Natural component is that encounter fungi be a kind of plant alexin for generating when plant encounters fungi invasion to plant, therefore is had very strong Antibacterial and anti-inflammation functions.Resveratrol just has the main pathogenic bacteria for the porphyromonas gingivalis for causing periodontosis in correlative study Certain bactericidal effect.

Sitosterol belongs to phytosterol, and phytosterol is the raw materials for production of steroid drug and vitamine D3.Sitosterol is to skin Skin has mild permeability, can inhibit the inflammation of skin, promotes sebum secretion and mild and keep moisture, guarantees that skin wet is soft It is soft, it can treat canker sore and periodontitis.Because of sitosterol safety, and there are many physiological action, it is suitble to be used for a long time, sitosterol It has been used as anti-inflammatory agent to be loaded into multinational pharmacopeia.

Antierythrite is a kind of natural, zero calory, alternative sucrose bulk sweetener, while being also that one kind is efficiently protected Humectant.Antierythrite has not saprodontia characteristic, promotes the effect of proliferation of intestinal probiotics.U.S. FDA assert antierythrite heat Value is 0.2kcal/g, than at present in sugarless products using the low nearly erythrose sugar of wider xylitol heat (2.4kcal/g) 12 times of alcohol energy.Performance of keeping humidity is better than glycerol and sorbierite simultaneously, has refrigerant sense, belongs to abiotic nutritional ingredient, has anti- Rotten function.

The sweetener in toothpaste mainly has saccharin sodium, the artificial synthesis edulcorants such as Sucralose at present, and long-time service has Certain is pathogenic.And the natural high sweetener that steviol glycoside is extracted from STEVIA REBAUDIANA, steviol glycoside stability are high, favorably In reducing viscosity, inhibit bacterial growth, extends shelf life of products, not blood glucose increasing, non-saprodontia.By Food and Drug Administration FDA and the food additives joint specialist committee regard as safe sweetener.

Summary of the invention

Present invention aims at providing one kind for people to can solve oral health issue, and with preferable safety containing white Veratryl alcohol obtains sugar-free toothpaste.

The present invention is mainly by resveratrol, sitosterol, antierythrite, glycerol, steviol glycoside, sodium bicarbonate, surface-active Agent, rubbing agent, gelling agent, anti-allergic agent, fruity flavor, brightening agent and deionized water are made, and the pH value of the sugar-free toothpaste is 6.5~9.

Advantage of the invention has:

1, by resveratrol and the mutual synergistic function of sitosterol, there is stronger bactericidal antiphlogistic, dispel the effect of pain.It is white Veratryl alcohol and antierythrite all have moistening effect, effectively reduce the additive amounts such as organic solvent propylene glycol, glycerol, of the invention Water uses deionized water, organic solvent-free, environmentally protective safer.

2, pH value is 6.5~9, is in weak basic condition.Tooth keeps alkaline environment, is due to addition plus sodium bicarbonate. Sodium bicarbonate is a kind of particularly effective grinding agent simultaneously, also provides mild tooth whitening effect.Acidic saliva is neutralized, from And keep the alkaline environment in oral cavity, while may remain in brush teeth a few hours after remain alkaline environment, can press down under alkaline environment System and the formation for hindering plaque, while fungistatic effect is better than acid and neutral item under alkaline condition for resveratrol and sitosterol Part.Sodium bicarbonate is natural teeth whitening, due to its abrasive action, can more effectively remove brown and yellow on tooth Spot.When brushing teeth simultaneously, sodium bicarbonate can penetrate into the enamel of tooth, facilitate the spot for reducing dental surface.

3, sweetener uses steviol glycoside, and the sweetener that conventional toothpaste uses is Aspartame, saccharin sodium and Sucralose Equal artificial synthesis edulcorants, long-term or excessive eat do certain harm to body.Steviol glycoside is extracted from natural, is belonged to In natural sweetener, while the non-fermented that stevioside has reduces bacterium so that it will not be utilized by the bacterium in oral cavity Nutriment needed for growth also reduces the acid in oral cavity.

To sum up toothpaste of the present invention has good bactericidal antiphlogistic effect, and oral bacteria is inhibited to breed, and inhibits plaque, keeps Breath freshening reduces bleeding gums, Sprouting resistance disease effect.

Further, resveratrol, sitosterol, antierythrite account for sugar-free toothpaste gross mass respectively in toothpaste of the present invention 0.2~3%, 2~5% and 5~60%.Resveratrol and sitosterol are used cooperatively the sterilization than single use resveratrol, sitosterol Antiinflammation is stronger, inhibits oral bacteria to breed, achievees the effect that synergy.Reach certain inhibiting bacteria and diminishing inflammation effect, and Taking cost into account, Resveratrol content range is 0.2~3%, and sitosterol content range is 2~5%.Antierythrite is in the toothpaste Play the role of efficient moisture-retention in formula, additive amount is relatively high, can accelerate to merge each substance, form uniform medium, simultaneously Antierythrite can inhibit bacterial growth in oral cavity, destroy the formation of plaque, and the effect of anti-caries is very significant, and the characteristic of itself exists Refrigerant sense is generated in oral cavity, addition antierythrite is the more effective approach for solving oral problem.The invention toothpaste it is main at It is divided into natural, the mild common substance of safety, performance, very small to oral cavity irritation, mutual cooperation forms oral cavity good Protective effect, and oral problem is solved in all directions.

It is another object of the present invention to propose the production method of the above toothpaste.

The present invention the following steps are included:

1) resveratrol, sitosterol, antierythrite, glycerol, steviol glycoside and sodium bicarbonate are dissolved in deionized water, are obtained Mixed solution；

2) mixed solution is added in vacuum viscolizer, then surfactant, rubbing agent, gelling agent, anti-allergic agent, fruity is fragrant Essence and brightening agent are added in homogenizer, agitated to handle 50~60min under -0.096mPa vacuum condition after mixing, take The sugar-free toothpaste of resveratrol must be contained.

The production method of the invention mainly comprises the following steps dissolution, homogeneous, vacuum processing, and method is simple, and physical mixed is uniform, nothing Chemical change keeps property of raw material；Reinforce the interaction between each substance under vacuum negative pressure condition, each raw material is sufficiently mixed It is even；Whole process is easy to operate, mild condition, no waste, and energy-saving and emission-reduction are environmentally protective.

In addition, above-mentioned steps 1) in, the temperature condition of dissolution is 50~80 DEG C.Effective component can be sufficiently molten at this temperature Solution, while loss of effective components rate is almost nil, obtains efficiently uniform lotion.

The resveratrol, sitosterol, antierythrite the quality that feeds intake account for 0.2~3%, the 2 of sugar-free toothpaste gross mass respectively ~5% and 5~60%.

The surfactant be lauryl sodium sulfate, sucrose fatty ester, cocoanut fatty acid diethanolamide its In two kinds.In the present invention, the purpose that surfactant is added is to help plaque and dental surface by reducing surface tension Other clasts loosen, to promote the distribution of toothpaste in the oral cavity, while also contributing to the barbotage of toothpaste.It is wherein selected The lauryl sodium sulfate selected, sucrose fatty ester, cocoanut fatty acid diethanolamide are to be applied to toothpaste, hair cream at present Range is wider in equal daily necessities, and degree of recognition is higher, has good foaming foam stabilizing effect, safe and healthy surfactant.

The rubbing agent is at least one of aluminium hydroxide, calcium monohydrogen phosphate or calcium pyrophosphate, and rubbing agent is as insoluble Grain helps to remove the plaque on tooth, and removing plaque and dental calculus helps to reduce decayed tooth and periodontosis.Three kinds of rubbing agents Granularity is thicker, has stronger frictional force, but not damage enamel, and can increase the brightness of toothpaste, and have excellent The power that cleans the teeth.

The gelling agent is carragheen, sodium carboxymethylcellulose, sodium alginate, at least any two in gum arabic Kind.Ingredient in toothpaste is uniformly dispersed by addition gelling agent effect, and exquisite in texture, gelling agent itself has good antienzyme, resistance to Salt, in heat to having higher stability in acid or alkali environment, mutually for compounding so that toothpaste system stability is high, holding is elastic.

The anti-allergic agent be potassium citrate, potassium chloride, potassium tartrate, in saleratus at least any one.Tooth sheet Matter allergy is to cause the disease of the sharp pain of transience when tooth is by outside stimulus such as temperature, machinery, chemistry.Using anti- Allergy toothpaste is treatment this disease most simple and convenient, economical and practical non-invasive treatment method, and Chinese dentistry meeting Dentine hypersensitivity expert group is to the preferred recommended method of the disease, wherein antiallergic effect containing sylvite is than more significant.

Specific embodiment

One, production technology:

Embodiment 1

It feeds intake by following weight percent: resveratrol 0.5%, sitosterol 3%, antierythrite 19%, glycerol 13%, stevioside Glycosides 0.05%, sodium bicarbonate 10%, lauryl sodium sulfate 2.3%, sucrose fatty ester 2%, calcium monohydrogen phosphate 32%, carboxymethyl cellulose Plain sodium 1%, sodium alginate 4%, potassium citrate 3%, deionized water 10%, green lemon essence 0.15%.

Production method:

1, by resveratrol 1kg, sitosterol 6kg, antierythrite 38kg, glycerol 26kg, steviol glycoside 0.1kg, sodium bicarbonate 20kg, portions of de-ionized water 15kg are heated at 70 DEG C, so that each composition is dissolved in deionized water, are obtained mixed solution.

2, mixed solution full dose is added in vacuum viscolizer, then by lauryl sodium sulfate 4.6kg, sucrose fatty ester 4kg, calcium monohydrogen phosphate 64kg, sodium carboxymethylcellulose 2kg, sodium alginate 8kg, potassium citrate 6kg, green lemon essence 0.3kg add Enter in homogenizer, remaining deionized water 5kg is added in whipping process, stirring 30min forms lotion.Then vacuum pump is opened, Until vacuum degree reaches -0.096MPa, after 50~60min of retention time, 200kg elasticity lotion is obtained.

3, elastic lotion is dispensed, obtains pipe dress toothpaste.

Embodiment 2

It feeds intake by following weight percent: resveratrol 0.55%, sitosterol 3.2%, antierythrite 12%, glycerol 12%, sweet tea Synanthrin glycosides 0.06%, sodium bicarbonate 11%, lauryl sodium sulfate 2.5%, cocoanut fatty acid diethanolamide 2.5%, phosphoric acid hydrogen Calcium 37%, sodium carboxymethylcellulose 1.04%, sodium alginate 4%, potassium citrate 3%, deionized water 11%, vanilla flavored essence 0.15%.

Production method:

1, by resveratrol 1.1kg, sitosterol 6.4kg, antierythrite 24kg, glycerol 24kg, steviol glycoside 0.12kg, bicarbonate Sodium 22kg and portions of de-ionized water 15kg are dissolved by heating at 70 DEG C, obtain mixed solution.

2, mixed solution full dose is added in vacuum viscolizer, then by lauryl sodium sulfate 5kg, coco-nut oil fatty acid two Glycollic amide 5kg, calcium monohydrogen phosphate 74kg, sodium carboxymethylcellulose 2.08kg, sodium alginate 8kg, potassium citrate 6kg, green lemon Essence 0.3kg is added in homogenizer, by remaining deionized water 7kg in whipping process, stirs 30min and forms lotion, opens true Sky pump, until vacuum degree reaches -0.096Mpa, after 50~60min of retention time, obtains 200kg elasticity lotion.

3, elastic lotion is dispensed, obtains pipe dress toothpaste.

Embodiment 3

It feeds intake by following weight percent: resveratrol 0.7%, sitosterol 3.5%, antierythrite 12%, glycerol 13%, stevia rebaudianum Glucosides 0.12%, sodium bicarbonate 13%, sucrose fatty ester 2%, cocoanut fatty acid diethanolamide 2.3%, calcium monohydrogen phosphate 34%, Sodium carboxymethylcellulose 1.2%, sodium alginate 5.52%, potassium tartrate 3.51%, deionized water 9%, lemon extract 0.15%.

Production method:

1, by resveratrol 1.4kg, sitosterol 7kg, antierythrite 24kg, glycerol 26kg, steviol glycoside 0.24kg, sodium bicarbonate 26kg, portions of de-ionized water 15kg are dissolved by heating at 70 DEG C, obtain mixed solution.

2, mixed solution is added in vacuum viscolizer, then by sucrose fatty ester 4kg, coco-nut oil fatty acid diethanol acyl Amine 4.6kg, calcium monohydrogen phosphate 68kg, sodium carboxymethylcellulose 2.4kg, sodium alginate 11.04kg, potassium citrate 7.02kg, green lemon Lemon essence 0.3kg is added in homogenizer, by remaining deionized water 3kg in whipping process, stirs 30min and forms lotion, open Vacuum pump, until vacuum degree reaches -0.096Mpa, after 50~60min of retention time, obtain 200kg elasticity lotion.

3, elastic lotion is dispensed, obtains pipe dress toothpaste.

Two, product test and result:

The obtained toothpaste of above-described embodiment is subjected to inhibition plaque, mitigation gingivitis effect, mitigates dentine hypersensitivity Effect and other effects is tested.

Subject 30, every 10 people is randomly divided into one group, and first group uses 1 toothpaste of embodiment, and second group uses embodiment 2 Toothpaste, third group use 3 toothpaste of embodiment, and subject is oral inflammation patient, wherein 5 people of women, 5 people of male, and the age exists 20-25 years old, the test period was 14 days, during test must not toothwash, dental floss must not be used, twice daily (morning and sleep before), often Secondary brushing time is 2 minutes, gingivitis index, bleeding index, antiallergy index, plaque after record the 7th day and the 14th day The clinical parameter of index and Sprouting resistance disease power exponent, and tooth is compared and is photographed to record, it is recorded after the 7th day and the 14th day As a result as shown in the table:

Test result: obtaining from above-mentioned table, and dental health problems have part improvement after 1 week, subject's gum after 2 weeks Inflammation obtains the effective treatment, and reaches 90% or more to bleeding gums, plaque treatment rate, at the same tooth improve antiallergy and Antiacid curative effect illustrates that the present invention can solve the problems, such as tooth gum in all directions, can be safe to use.

Claims

1. a kind of sugar-free toothpaste containing resveratrol, it is characterised in that mainly by resveratrol, sitosterol, antierythrite, glycerol, Steviol glycoside, sodium bicarbonate, surfactant, rubbing agent, gelling agent, anti-allergic agent, fruity flavor, brightening agent and deionized water It is made, the pH value of the sugar-free toothpaste is 6.5~9.

2. the sugar-free toothpaste containing resveratrol according to claim 1, it is characterised in that the resveratrol, sitosterol, red Moss sugar alcohol accounts for 0.2~3%, 2~5% and the 5~60% of sugar-free toothpaste gross mass respectively.

3. the production method of the sugar-free toothpaste containing resveratrol as described in claim 1, it is characterised in that the following steps are included:

4. the production method of the sugar-free toothpaste containing resveratrol according to claim 3, it is characterised in that in the step 1), The temperature condition of dissolution is 50~80 DEG C.

5. the production method of the sugar-free toothpaste according to claim 3 or 4 containing resveratrol, it is characterised in that the white black false hellebore Alcohol, sitosterol, antierythrite the quality that feeds intake account for 0.2~3%, 2~5% and the 5~60% of sugar-free toothpaste gross mass respectively.

6. the production method of the sugar-free toothpaste containing resveratrol according to claim 3, it is characterised in that the surface-active Agent is lauryl sodium sulfate, sucrose fatty ester, at least any two kinds in cocoanut fatty acid diethanolamide.

7. the production method of the sugar-free toothpaste containing resveratrol according to claim 3, it is characterised in that the rubbing agent is Aluminium hydroxide, calcium monohydrogen phosphate or calcium pyrophosphate.

8. the production method of the sugar-free toothpaste containing resveratrol according to claim 3, it is characterised in that the gelling agent is Carragheen, sodium carboxymethylcellulose, sodium alginate, in gum arabic at least any one.

9. the production method of the sugar-free toothpaste containing resveratrol according to claim 3, it is characterised in that the anti-allergic agent For in potassium citrate, potassium chloride, potassium tartrate, saleratus at least any one.