CN107095827A - One kind is antibacterial to remove stain Chinese medicinal toothpaste and preparation method thereof - Google Patents
One kind is antibacterial to remove stain Chinese medicinal toothpaste and preparation method thereof Download PDFInfo
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- CN107095827A CN107095827A CN201710519228.5A CN201710519228A CN107095827A CN 107095827 A CN107095827 A CN 107095827A CN 201710519228 A CN201710519228 A CN 201710519228A CN 107095827 A CN107095827 A CN 107095827A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/236—Ligusticum (licorice-root)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/489—Sophora, e.g. necklacepod or mamani
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
- A61K36/634—Forsythia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/805—Corresponding aspects not provided for by any of codes A61K2800/81 - A61K2800/95
Abstract
The invention discloses one kind it is antibacterial remove stain Chinese medicinal toothpaste, include the raw material of following parts by weight：Go 15 25 parts of stain Chinese medicine, 10 20 parts of bacteriostatic Chinese medicinal, 7 11 parts of rubbing agent, 24 parts of xylitol, 57 parts of NMF, 0.5 0.9 parts of foaming agent, 13 parts of Tea Polyphenols, 12 parts of thickener, 8 12 parts of deionized water.The Chinese medicinal toothpaste of the present invention can effectively suppress and remove bacterial plaque, effectively kill cariogenic bacteria, pre- anti-caries, and can protect mucous membrane of mouth, fresh breath, alleviate the symptoms such as swelling and aching of gum；The materials safety prepared simultaneously is nontoxic, and material is easy to get, production cost is relatively low, technique is concise, with higher practical value and good application prospect.
Description
Technical field
The present invention relates to Chinese medicine deep process technology field, and in particular to one kind is antibacterial to go to stain Chinese medicinal toothpaste and its preparation side
Method.
Background technology
Toothpaste is to be used to clean tooth together with toothbrush, protects oral hygiene, a kind of daily necessities safe to the human body.
As the improvement of people's living standards, also being stepped up to the quality requirement of toothpaste.Toothpaste is typically required in aspect of performance：（1）
The film and bacterial plaque of dental surface can be removed without damaging enamel and dentine；（2）With good cleaning oral cavity and its
The effect of surrounding；（3）Nontoxicity, it is non-stimulated to oral mucosa；（4）Having after comfortable fragrance and taste, use has cool and sweet-smelling
Sensation.
The existing toothpaste with sterilizing function, some addition antibiotic, disinfectant, such as triclosan, chlorohexidene will be harmful
Bacterium, beneficial bacterium are all killed, and are destroyed Oral health behaviours environment, are added the resistance to the action of a drug of bacterium.Therefore a kind of effectively suppression is invented
Harmful bacteria growing, the reparation and defence that improve Oral health behaviours, promote oral mucosa are formed with, with sterilization and prevention, treatment carious tooth
Function, easy to use, treatment cost are low, popularize extensive antibacterial Chinese medicine toothpaste, are very significant.
The content of the invention
For the defect of prior art, stain Chinese medicinal toothpaste is removed it is an object of the invention to provide one kind is antibacterial, the Chinese medicinal toothpaste
It can effectively suppress and remove bacterial plaque, effectively kill cariogenic bacteria, pre- anti-caries, and mucous membrane of mouth, fresh breath can be protected, delayed
Solve the symptoms such as swelling and aching of gum；Simultaneously prepare materials safety it is nontoxic, material is easy to get, production cost is relatively low, technique is concise, with compared with
High practical value and good application prospect.
The present invention solves technical problem and adopted the following technical scheme that：
The invention provides one kind it is antibacterial remove stain Chinese medicinal toothpaste, include the raw material of following parts by weight：
Go 15-25 parts of stain Chinese medicine, 10-20 parts of bacteriostatic Chinese medicinal, 7-11 parts of rubbing agent, 2-4 parts of xylitol, 5-7 parts of NMF, foaming
0.5-0.9 parts of agent, 1-3 parts of Tea Polyphenols, 1-2 parts of thickener, 8-12 parts of deionized water.
Preferably, the antibacterial raw material for going stain Chinese medicinal toothpaste to include following parts by weight：
Go 20 parts of stain Chinese medicine, 15 parts of bacteriostatic Chinese medicinal, 9 parts of rubbing agent, 3 parts of xylitol, 6 parts of NMF, 0.7 part of foaming agent, tea many
2 parts of phenol, 1.5 parts of thickener, 10 parts of deionized water.
Preferably, it is described to go stain Chinese medicine to be rattletop, Jehol Ligusticum Rhizome, the root of Dahurain angelica, compare 1 according to weight:2:The mixture of 1 composition.
Preferably, the bacteriostatic Chinese medicinal is kuh-seng, radix glycyrrhizae, Folium Forsythia, compares 2 according to weight:1:The mixture of 2 compositions.
Preferably, the rubbing agent is calcium phosphate dibasic dihydrate, anhydride silica, calcite in powder, compares 1 according to weight:
1:The mixture of 2 compositions.
Preferably, the NMF is that glycerine, sorbierite, polyethylene glycol compare 2 according to weight:1:The mixture of 3 compositions.
Preferably, the foaming agent is in lauryl sodium sulfate, methyl cocoa ester group sodium taurocholate, acyl glutamic acid sodium
One or more.
Preferably, the thickener is that sodium alginate, carboxymethyl cellulose, HPG compare 2 according to weight:1:1
The mixture of composition.
The present invention also provides a kind of antibacterial preparation method for removing stain Chinese medicinal toothpaste, comprises the following steps：
Step one, weigh on request and prepare each component raw material；
Step 2, yellow bacteriostatic Chinese medicinal is added in high speed disintegrator and crushed, the mixture after crushing is added into 10-12 times of its weight
Water, after boiling decoct 3-5 hours, solid and liquid separation；Add 8-10 times to measure water the residue after first time water extraction again to carry out second
Water extraction, is extracted 1-3 hours, solid and liquid separation；Add 6-8 times to measure water the residue after second of water extraction again and carry out third time water extraction,
Extract 1-3 hours, solid and liquid separation；Merge three aqueous extracts, concentration obtains concentrate A；
Step 3, will go stain Chinese medicine to add in high speed disintegrator and crushes, and mixture plus concentration are extracted into secondary for 70% ethanol,
Wherein add 8-10 times for the first time and measure solvent, extract 2-4 hours, solid and liquid separation；Residue after first time alcohol extracting adds 6-8 times to measure
Ethanol carries out second of alcohol extracting, extracts 1-3 hours, solid and liquid separation；Merge secondary ethanol extract, be concentrated under reduced pressure recycling design,
Obtain concentrate B；
Concentrate B prepared by step 4, concentrate A prepared by step 2 and step 3 merges, and remixes rubbing agent, xylose
Alcohol, NMF, foaming agent, Tea Polyphenols, thickener, deionized water are added in homogenizer, and low whipping speed is 200-300r/
Min, temperature is placed in vacuum Manufacturing medicine extract machine and carried out after homogenization to be stirred 20-30 minutes at 55-65 DEG C, filling to produce this hair
It is bright antibacterial to remove stain Chinese medicinal toothpaste.
Preferably, it is described antibacterial to go the stain Chinese medicinal toothpaste preparation process to be：
Step one, weigh on request and prepare each component raw material；
Step 2, yellow bacteriostatic Chinese medicinal is added in high speed disintegrator and crushed, the mixture after crushing is added into 11 times of its weight
Water, is decocted 4 hours, solid and liquid separation after boiling；Add 9 times of amount water to carry out second of water extraction the residue after first time water extraction again, carry
Take 2 hours, solid and liquid separation；Add 7 times of amount water to carry out third time water extraction the residue after second of water extraction again, extract 2 hours, Gu,
Liquid is separated；Merge three aqueous extracts, concentration obtains concentrate A；
Step 3, will go stain Chinese medicine to add in high speed disintegrator and crushes, and mixture plus concentration are extracted into secondary for 70% ethanol,
Wherein add 9 times of amount solvents for the first time, extract 4 hours, solid and liquid separation；Residue after first time alcohol extracting adds 7 times of amount ethanol to carry out the
Secondary alcohol extracting, is extracted 2 hours, solid and liquid separation；Merge secondary ethanol extract, be concentrated under reduced pressure recycling design, obtain concentrate B；
Concentrate B prepared by step 4, concentrate A prepared by step 2 and step 3 merges, and remixes rubbing agent, xylose
Alcohol, NMF, foaming agent, Tea Polyphenols, thickener, deionized water are added in homogenizer, and low whipping speed is 250r/min,
Temperature is placed in vacuum Manufacturing medicine extract machine and carried out after homogenization to be stirred 25 minutes at 60 DEG C, filling to produce the antibacterial of the present invention
Stain Chinese medicinal toothpaste.
Compared with prior art, the present invention has following beneficial effect：
（1）The present invention it is a kind of it is antibacterial go stain Chinese medicinal toothpaste to remove stain Chinese medicine for rattletop, Jehol Ligusticum Rhizome, the root of Dahurain angelica, the thing of active composition
Matter, not only removes the exogenous spot effect of tooth with obvious, and low to the excitant of mucous membrane of mouth, tooth.
（2）A kind of antibacterial bacteriostatic Chinese medicinal for going stain Chinese medicinal toothpaste to add of the present invention is kuh-seng, radix glycyrrhizae, Folium Forsythia, several persons
All it is bactericide, suppresses and kill HP and cariogenic bacteria, bacterium can be reduced and stick and assemble, the knot of said components comprehensive function
Really, make toothpaste of the present invention that there is the effect for killing oral bacteria and cariogenic bacteria.
（3）The present invention it is a kind of it is antibacterial remove the general types that stain Chinese medicinal toothpaste is the field of Chinese medicines, abundant raw material, the present invention
Preparation method in, first Chinese medicine is extracted, then concentrate, is finally eluted, can effectively remove various impurity in Chinese medicine, no
The purity of Chinese medicine is only effectively increased, and avoids infringement of all kinds of impurity to user, the safety of Chinese medicine preparation is improved
Property and validity.
（4）The present invention it is a kind of it is antibacterial go stain Chinese medicinal toothpaste effectively to suppress and remove bacterial plaque, effectively kill cariogenic bacteria,
Pre- anti-caries, and mucous membrane of mouth, fresh breath can be protected, alleviate the symptoms such as swelling and aching of gum；Simultaneously prepare materials safety without
Poison, material is easy to get, production cost is relatively low, technique is concise, with higher practical value and good application prospect.
Embodiment
With reference to specific embodiment, the technical scheme in the embodiment of the present invention is clearly and completely described, shown
So, described embodiment is only a part of embodiment of the invention, rather than whole embodiments.Based on the reality in the present invention
Example is applied, the every other embodiment that those of ordinary skill in the art are obtained under the premise of creative work is not made all belongs to
In the scope of protection of the invention.
Embodiment 1.
The present embodiment it is a kind of it is antibacterial remove stain Chinese medicinal toothpaste, include the raw material of following parts by weight：
Remove 15 parts of stain Chinese medicine, 10 parts of bacteriostatic Chinese medicinal, 7 parts of rubbing agent, 2 parts of xylitol, 5 parts of NMF, foaming agent 0.5, Tea Polyphenols 1
Part, 1 part of thickener, 8 parts of deionized water.
Go stain Chinese medicine to be rattletop, Jehol Ligusticum Rhizome, the root of Dahurain angelica in the present embodiment, compare 1 according to weight:2:The mixture of 1 composition.
Bacteriostatic Chinese medicinal in the present embodiment is kuh-seng, radix glycyrrhizae, Folium Forsythia, compares 2 according to weight:1:The mixture of 2 compositions.
Rubbing agent in the present embodiment is calcium phosphate dibasic dihydrate, anhydride silica, calcite in powder, compares 1 according to weight:
1:The mixture of 2 compositions.
NMF in the present embodiment is glycerine, sorbierite, polyethylene glycol compare 2 according to weight:1:The mixing of 3 compositions
Thing.
Foaming agent in the present embodiment is lauryl sodium sulfate.
Thickener in the present embodiment is sodium alginate, carboxymethyl cellulose, HPG compare 2 according to weight:1:1
The mixture of composition.
A kind of preparation method of effect of Compound Anshen Chinese hypotensor preparation of the present embodiment, comprises the following steps：
Step one, weigh on request and prepare each component raw material；
Step 2, yellow bacteriostatic Chinese medicinal is added in high speed disintegrator and crushed, the mixture after crushing is added into 10 times of its weight
Water, is decocted 3 hours, solid and liquid separation after boiling；Add 8 times of amount water to carry out second of water extraction the residue after first time water extraction again, carry
Take 1 hour, solid and liquid separation；Add 6 times of amount water to carry out third time water extraction the residue after second of water extraction again, extract 1 hour,
Solid and liquid separation；Merge three aqueous extracts, concentration obtains concentrate A；
Step 3, will go stain Chinese medicine to add in high speed disintegrator and crushes, and mixture plus concentration are extracted into secondary for 70% ethanol,
Wherein add 8 times of amount solvents for the first time, extract 2-4 hours, solid and liquid separation；Residue after first time alcohol extracting adds 6 times of amount ethanol to carry out
Second of alcohol extracting, is extracted 1 hour, solid and liquid separation；Merge secondary ethanol extract, be concentrated under reduced pressure recycling design, obtains concentrate
B；
Concentrate B prepared by step 4, concentrate A prepared by step 2 and step 3 merges, and remixes rubbing agent, xylose
Alcohol, NMF, foaming agent, Tea Polyphenols, thickener, deionized water are added in homogenizer, and low whipping speed is 200r/min,
Temperature is placed in vacuum Manufacturing medicine extract machine and carried out after homogenization to be stirred 20 minutes at 55 DEG C, filling to produce the antibacterial of the present invention
Stain Chinese medicinal toothpaste.
Embodiment 2.
The present embodiment it is a kind of it is antibacterial remove stain Chinese medicinal toothpaste, include the raw material of following parts by weight：
Go 25 parts of stain Chinese medicine, 20 parts of bacteriostatic Chinese medicinal, 11 parts of rubbing agent, 4 parts of xylitol, 7 parts of NMF, 0.9 part of foaming agent, tea many
3 parts of phenol, 2 parts of thickener, 12 parts of deionized water.
Go stain Chinese medicine to be rattletop, Jehol Ligusticum Rhizome, the root of Dahurain angelica in the present embodiment, compare 1 according to weight:2:The mixture of 1 composition.
Bacteriostatic Chinese medicinal in the present embodiment is kuh-seng, radix glycyrrhizae, Folium Forsythia, compares 2 according to weight:1:The mixture of 2 compositions.
Rubbing agent in the present embodiment is calcium phosphate dibasic dihydrate, anhydride silica, calcite in powder, compares 1 according to weight:
1:The mixture of 2 compositions.
NMF in the present embodiment is glycerine, sorbierite, polyethylene glycol compare 2 according to weight:1:The mixing of 3 compositions
Thing.
Foaming agent in the present embodiment is methyl cocoa ester group sodium taurocholate.
Thickener in the present embodiment is sodium alginate, carboxymethyl cellulose, HPG compare 2 according to weight:1:1
The mixture of composition.
A kind of preparation method of effect of Compound Anshen Chinese hypotensor preparation of the present embodiment, comprises the following steps：
Step one, weigh on request and prepare each component raw material；
Step 2, yellow bacteriostatic Chinese medicinal is added in high speed disintegrator and crushed, the mixture after crushing is added into 12 times of its weight
Water, is decocted 5 hours, solid and liquid separation after boiling；10 times of amount water are added to carry out second of water extraction the residue after first time water extraction again,
Extract 3 hours, solid and liquid separation；Add 8 times of amount water to carry out third time water extraction the residue after second of water extraction again, extract 3 hours,
Solid and liquid separation；Merge three aqueous extracts, concentration obtains concentrate A；
Step 3, will go stain Chinese medicine to add in high speed disintegrator and crushes, and mixture plus concentration are extracted into secondary for 70% ethanol,
Wherein add 10 times of amount solvents for the first time, extract 4 hours, solid and liquid separation；Residue after first time alcohol extracting adds 8 times of amount ethanol to enter
Second of alcohol extracting of row, is extracted 3 hours, solid and liquid separation；Merge secondary ethanol extract, be concentrated under reduced pressure recycling design, is concentrated
Liquid B；
Concentrate B prepared by step 4, concentrate A prepared by step 2 and step 3 merges, and remixes rubbing agent, xylose
Alcohol, NMF, foaming agent, Tea Polyphenols, thickener, deionized water are added in homogenizer, and low whipping speed is 300r/min,
Temperature is placed in vacuum Manufacturing medicine extract machine and carried out after homogenization to be stirred 30 minutes at 65 DEG C, filling to produce the antibacterial of the present invention
Stain Chinese medicinal toothpaste.
Embodiment 3.
The present embodiment it is a kind of it is antibacterial remove stain Chinese medicinal toothpaste, include the raw material of following parts by weight：
Go 20 parts of stain Chinese medicine, 15 parts of bacteriostatic Chinese medicinal, 9 parts of rubbing agent, 3 parts of xylitol, 6 parts of NMF, 0.7 part of foaming agent, tea many
2 parts of phenol, 1.5 parts of thickener, 10 parts of deionized water.
Go stain Chinese medicine to be rattletop, Jehol Ligusticum Rhizome, the root of Dahurain angelica in the present embodiment, compare 1 according to weight:2:The mixture of 1 composition.
Bacteriostatic Chinese medicinal in the present embodiment is kuh-seng, radix glycyrrhizae, Folium Forsythia, compares 2 according to weight:1:The mixture of 2 compositions.
Rubbing agent in the present embodiment is calcium phosphate dibasic dihydrate, anhydride silica, calcite in powder, compares 1 according to weight:
1:The mixture of 2 compositions.
NMF in the present embodiment is glycerine, sorbierite, polyethylene glycol compare 2 according to weight:1:The mixing of 3 compositions
Thing.
Foaming agent in the present embodiment is acyl glutamic acid sodium.
Thickener in the present embodiment is sodium alginate, carboxymethyl cellulose, HPG compare 2 according to weight:1:1
The mixture of composition.
A kind of preparation method of effect of Compound Anshen Chinese hypotensor preparation of the present embodiment, comprises the following steps：
Step one, weigh on request and prepare each component raw material；
Step 2, yellow bacteriostatic Chinese medicinal is added in high speed disintegrator and crushed, the mixture after crushing is added into 11 times of its weight
Water, is decocted 4 hours, solid and liquid separation after boiling；Add 9 times of amount water to carry out second of water extraction the residue after first time water extraction again, carry
Take 2 hours, solid and liquid separation；Add 7 times of amount water to carry out third time water extraction the residue after second of water extraction again, extract 2 hours, Gu,
Liquid is separated；Merge three aqueous extracts, concentration obtains concentrate A；
Step 3, will go stain Chinese medicine to add in high speed disintegrator and crushes, and mixture plus concentration are extracted into secondary for 70% ethanol,
Wherein add 9 times of amount solvents for the first time, extract 4 hours, solid and liquid separation；Residue after first time alcohol extracting adds 7 times of amount ethanol to carry out the
Secondary alcohol extracting, is extracted 2 hours, solid and liquid separation；Merge secondary ethanol extract, be concentrated under reduced pressure recycling design, obtain concentrate B；
Concentrate B prepared by step 4, concentrate A prepared by step 2 and step 3 merges, and remixes rubbing agent, xylose
Alcohol, NMF, foaming agent, Tea Polyphenols, thickener, deionized water are added in homogenizer, and low whipping speed is 250r/min,
Temperature is placed in vacuum Manufacturing medicine extract machine and carried out after homogenization to be stirred 25 minutes at 60 DEG C, filling to produce the antibacterial of the present invention
Stain Chinese medicinal toothpaste.
The present invention it is a kind of it is antibacterial go stain Chinese medicinal toothpaste effectively to suppress and remove bacterial plaque, effectively kill cariogenic bacteria, in advance
Anti-caries, and mucous membrane of mouth, fresh breath can be protected, alleviate the symptoms such as swelling and aching of gum；The materials safety prepared simultaneously is nontoxic,
Material is easy to get, production cost is relatively low, technique is concise, with higher practical value and good application prospect.
It is obvious to a person skilled in the art that the invention is not restricted to the details of above-mentioned one exemplary embodiment, Er Qie
In the case of without departing substantially from spirit or essential attributes of the invention, the present invention can be realized in other specific forms.Therefore, no matter
From the point of view of which point, embodiment all should be regarded as exemplary, and be nonrestrictive, the scope of the present invention is by appended power
Profit is required rather than described above is limited, it is intended that all in the implication and scope of the equivalency of claim by falling
Change is included in the present invention.
Moreover, it will be appreciated that although the present specification is described in terms of embodiments, not each embodiment is only wrapped
Containing an independent technical scheme, this narrating mode of specification is only that for clarity, those skilled in the art should
Using specification as an entirety, the technical solutions in the various embodiments may also be suitably combined, forms those skilled in the art
It may be appreciated other embodiment.
Claims (10)
1. one kind is antibacterial to remove stain Chinese medicinal toothpaste, it is characterised in that include the raw material of following parts by weight：
Go 15-25 parts of stain Chinese medicine, 10-20 parts of bacteriostatic Chinese medicinal, 7-11 parts of rubbing agent, 2-4 parts of xylitol, 5-7 parts of NMF, foaming
0.5-0.9 parts of agent, 1-3 parts of Tea Polyphenols, 1-2 parts of thickener, 8-12 parts of deionized water.
2. one kind according to claim 1 is antibacterial to remove stain Chinese medicinal toothpaste, it is characterised in that described antibacterial to remove stain Chinese medicinal toothpaste
Include the raw material of following parts by weight：
Go 20 parts of stain Chinese medicine, 15 parts of bacteriostatic Chinese medicinal, 9 parts of rubbing agent, 3 parts of xylitol, 6 parts of NMF, 0.7 part of foaming agent, tea many
2 parts of phenol, 1.5 parts of thickener, 10 parts of deionized water.
3. one kind according to claim 1 or 2 is antibacterial to remove stain Chinese medicinal toothpaste, it is characterised in that described to remove stain Chinese medicine to rise
Fiber crops, Jehol Ligusticum Rhizome, the root of Dahurain angelica, compare 1 according to weight:2:The mixture of 1 composition.
4. one kind according to claim 1 or 2 is antibacterial to remove stain Chinese medicinal toothpaste, it is characterised in that the bacteriostatic Chinese medicinal is hardship
Ginseng, radix glycyrrhizae, Folium Forsythia, compare 2 according to weight:1:The mixture of 2 compositions.
5. one kind according to claim 1 or 2 is antibacterial to remove stain Chinese medicinal toothpaste, it is characterised in that the rubbing agent is two water
Calcium monohydrogen phosphate, anhydride silica, calcite in powder are closed, compares 1 according to weight:1:The mixture of 2 compositions.
6. one kind according to claim 1 or 2 is antibacterial to remove stain Chinese medicinal toothpaste, it is characterised in that the NMF is the third three
Alcohol, sorbierite, polyethylene glycol compare 2 according to weight:1:The mixture of 3 compositions.
7. one kind according to claim 1 or 2 is antibacterial to remove stain Chinese medicinal toothpaste, it is characterised in that the foaming agent is 12
One or more in sodium alkyl sulfate, methyl cocoa ester group sodium taurocholate, acyl glutamic acid sodium.
8. one kind according to claim 1 or 2 is antibacterial to remove stain Chinese medicinal toothpaste, it is characterised in that the thickener is marine alga
Sour sodium, carboxymethyl cellulose, HPG compare 2 according to weight:1:The mixture of 1 composition.
9. a kind of prepare the antibacterial method for removing stain Chinese medicinal toothpaste as claimed in claim 1 or 2, it is characterised in that including following
Step：
Step one, weigh on request and prepare each component raw material；
Step 2, yellow bacteriostatic Chinese medicinal is added in high speed disintegrator and crushed, the mixture after crushing is added into 10-12 times of its weight
Water, after boiling decoct 3-5 hours, solid and liquid separation；Add 8-10 times to measure water the residue after first time water extraction again to carry out second
Water extraction, is extracted 1-3 hours, solid and liquid separation；Add 6-8 times to measure water the residue after second of water extraction again and carry out third time water extraction,
Extract 1-3 hours, solid and liquid separation；Merge three aqueous extracts, concentration obtains concentrate A；
Step 3, will go stain Chinese medicine to add in high speed disintegrator and crushes, and mixture plus concentration are extracted into secondary for 70% ethanol,
Wherein add 8-10 times for the first time and measure solvent, extract 2-4 hours, solid and liquid separation；Residue after first time alcohol extracting adds 6-8 times to measure
Ethanol carries out second of alcohol extracting, extracts 1-3 hours, solid and liquid separation；Merge secondary ethanol extract, be concentrated under reduced pressure recycling design,
Obtain concentrate B；
Concentrate B prepared by step 4, concentrate A prepared by step 2 and step 3 merges, and remixes rubbing agent, xylose
Alcohol, NMF, foaming agent, Tea Polyphenols, thickener, deionized water are added in homogenizer, and low whipping speed is 200-300r/
Min, temperature is placed in vacuum Manufacturing medicine extract machine and carried out after homogenization to be stirred 20-30 minutes at 55-65 DEG C, filling to produce this hair
It is bright antibacterial to remove stain Chinese medicinal toothpaste.
10. one kind according to claim 9 is antibacterial to go stain Chinese medicinal toothpaste preparation method, it is characterised in that the step is：
Step one, weigh on request and prepare each component raw material；
Step 2, yellow bacteriostatic Chinese medicinal is added in high speed disintegrator and crushed, the mixture after crushing is added into 11 times of its weight
Water, is decocted 4 hours, solid and liquid separation after boiling；Add 9 times of amount water to carry out second of water extraction the residue after first time water extraction again, carry
Take 2 hours, solid and liquid separation；Add 7 times of amount water to carry out third time water extraction the residue after second of water extraction again, extract 2 hours, Gu,
Liquid is separated；Merge three aqueous extracts, concentration obtains concentrate A；
Step 3, will go stain Chinese medicine to add in high speed disintegrator and crushes, and mixture plus concentration are extracted into secondary for 70% ethanol,
Wherein add 9 times of amount solvents for the first time, extract 4 hours, solid and liquid separation；Residue after first time alcohol extracting adds 7 times of amount ethanol to carry out the
Secondary alcohol extracting, is extracted 2 hours, solid and liquid separation；Merge secondary ethanol extract, be concentrated under reduced pressure recycling design, obtain concentrate B；
Concentrate B prepared by step 4, concentrate A prepared by step 2 and step 3 merges, and remixes rubbing agent, xylose
Alcohol, NMF, foaming agent, Tea Polyphenols, thickener, deionized water are added in homogenizer, and low whipping speed is 250r/min,
Temperature is placed in vacuum Manufacturing medicine extract machine and carried out after homogenization to be stirred 25 minutes at 60 DEG C, filling to produce the antibacterial of the present invention
Stain Chinese medicinal toothpaste.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108542832A (en) * | 2018-07-11 | 2018-09-18 | 佛山皖阳生物科技有限公司 | A kind of antibacterial liquid tooth paste |
| CN112156040A (en) * | 2020-08-05 | 2021-01-01 | 广州市名俐日用化工有限公司 | Internal heat-reducing halitosis-removing whitening toothpaste and preparation method thereof |
| CN112972355A (en) * | 2021-02-27 | 2021-06-18 | 厦门力嘉诚生物科技有限公司 | Traditional Chinese medicine toothpaste and preparation method thereof |
| CN116392410A (en) * | 2023-03-23 | 2023-07-07 | 段梅莉 | Functional toothpaste and preparation method thereof |
Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20010011005A (en) * | 1999-07-24 | 2001-02-15 | 서경배 | A method for preparation of salts containing extract of pine tree and oral compositions containing salts containing extract of pine tree prepared by the same |
| CN101081200A (en) * | 2006-05-29 | 2007-12-05 | 孙耀祖 | Novel oral health collutory |
| CN103599043A (en) * | 2013-10-31 | 2014-02-26 | 赵明 | Traditional Chinese medicine multiple-effect toothpaste |
| CN103800549A (en) * | 2012-11-12 | 2014-05-21 | 宗风英 | Traditional Chinese medicine formula for whitening teeth |
| CN103800551A (en) * | 2012-11-12 | 2014-05-21 | 宗风英 | Traditional Chinese medicine formula for whitening teeth |
| CN104940086A (en) * | 2015-07-13 | 2015-09-30 | 李丽芬 | Chinese herbal toothpaste capable of diminishing inflammation and eliminating halitosis |
| CN105012174A (en) * | 2015-07-10 | 2015-11-04 | 常州市荣顺电子有限公司 | Chinese herbal toothpaste containing vitamin C and preparation method of Chinese herbal toothpaste |
| CN105476938A (en) * | 2016-02-01 | 2016-04-13 | 东莞品派实业投资有限公司 | Chinese medicinal toothpaste and preparation method thereof |
-
2017
- 2017-06-30 CN CN201710519228.5A patent/CN107095827A/en not_active Withdrawn
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20010011005A (en) * | 1999-07-24 | 2001-02-15 | 서경배 | A method for preparation of salts containing extract of pine tree and oral compositions containing salts containing extract of pine tree prepared by the same |
| CN101081200A (en) * | 2006-05-29 | 2007-12-05 | 孙耀祖 | Novel oral health collutory |
| CN103800549A (en) * | 2012-11-12 | 2014-05-21 | 宗风英 | Traditional Chinese medicine formula for whitening teeth |
| CN103800551A (en) * | 2012-11-12 | 2014-05-21 | 宗风英 | Traditional Chinese medicine formula for whitening teeth |
| CN103599043A (en) * | 2013-10-31 | 2014-02-26 | 赵明 | Traditional Chinese medicine multiple-effect toothpaste |
| CN105012174A (en) * | 2015-07-10 | 2015-11-04 | 常州市荣顺电子有限公司 | Chinese herbal toothpaste containing vitamin C and preparation method of Chinese herbal toothpaste |
| CN104940086A (en) * | 2015-07-13 | 2015-09-30 | 李丽芬 | Chinese herbal toothpaste capable of diminishing inflammation and eliminating halitosis |
| CN105476938A (en) * | 2016-02-01 | 2016-04-13 | 东莞品派实业投资有限公司 | Chinese medicinal toothpaste and preparation method thereof |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108542832A (en) * | 2018-07-11 | 2018-09-18 | 佛山皖阳生物科技有限公司 | A kind of antibacterial liquid tooth paste |
| CN112156040A (en) * | 2020-08-05 | 2021-01-01 | 广州市名俐日用化工有限公司 | Internal heat-reducing halitosis-removing whitening toothpaste and preparation method thereof |
| CN112972355A (en) * | 2021-02-27 | 2021-06-18 | 厦门力嘉诚生物科技有限公司 | Traditional Chinese medicine toothpaste and preparation method thereof |
| CN116392410A (en) * | 2023-03-23 | 2023-07-07 | 段梅莉 | Functional toothpaste and preparation method thereof |
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Application publication date: 20170829 |