CN108158899A - A kind of mouthwash containing vine tea flavone extract and preparation method thereof - Google Patents
A kind of mouthwash containing vine tea flavone extract and preparation method thereof Download PDFInfo
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- CN108158899A CN108158899A CN201810180008.9A CN201810180008A CN108158899A CN 108158899 A CN108158899 A CN 108158899A CN 201810180008 A CN201810180008 A CN 201810180008A CN 108158899 A CN108158899 A CN 108158899A
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- vine tea
- mouthwash
- flavone extract
- tea flavone
- essence
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
- A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/87—Vitaceae or Ampelidaceae (Vine or Grape family), e.g. wine grapes, muscadine or peppervine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Veterinary Medicine (AREA)
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- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
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- Medical Informatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Alternative & Traditional Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Cosmetics (AREA)
Abstract
The invention belongs to chemical product technical fields more particularly to a kind of mouthwash containing vine tea flavone extract and preparation method thereof.The present invention provides a kind of mouthwashes containing vine tea flavone extract, by vine tea flavone extract, menthol, edible alcohol, moisturizer, active constituent stabilizer, surfactant, essence, sweetener, preservative and water are made, vine tea flavone extract is active components of plants, with antibacterial, anti-inflammatory, hemostasis, the effects that deodorization, the mouthwash can clean oral cavity, fresh breath, and, the mouthwash has concurrently antibacterial, anti-inflammatory, hemostasis, the multiple efficacies such as wet one's whistle, long-time service can effectively prevent canker sore, sphagitis, periodontitis, the mouthwash can be used for a long time, it has no toxic side effect.
Description
Technical field
The invention belongs to chemical product technical field more particularly to a kind of mouthwashes and its system containing vine tea flavone extract
Preparation Method.
Background technology
With the improvement of living standards, people also increasingly improve the health care consciousness of itself, oral health be also wherein it
One.The oral health of modern people mainly has seven big problems, including saprodontia, dental calculus, plaque, bleeding gums, dentine hypersensitivity,
Tooth is not pure white, implication.In order to eliminate this " painful topic ", various methods are used, such as brush teeth more, chew gum,
Eat tealeaves etc..Although these methods can achieve the effect that certain, preferable not enough, some is also inconvenient.
Mouthwash is the novel product of Technology Times, is indispensable oral-cavity cleaning products in people's daily life,
Basic function is cleaning tooth, fresh breath, achievees the purpose that keep oral cleaning.Now mouthwash majority in the market is containing fluorination
The ingredients such as sodium, triclosan, hydrogen peroxide, Cetyl Chloride, metronidazole and Tinidazole.Such mouthwash is respectively provided with sterilization suppression well
Bacterium acts on, but is not appropriate for oral care being used as to use for a long time.
Invention content
The present invention provides a kind of mouthwash containing vine tea flavone extract, is not suitable for for a long time for solving existing mouthwash
The problem of being used as oral care.
The specific technical solution of the present invention is as follows:
A kind of mouthwash containing vine tea flavone extract, by weight percentage, is made of following components:
Preferably, the extracting method of the vine tea flavone extract is as follows:
Vine tea powder in boiling water is extracted, obtains being concentrated again after extracting solution, dry, obtain vine tea flavone and carry
Take object.
Preferably, the volume ratio of the vine tea powder and boiling water is 1:5~20.
Preferably, the time of the extraction is 30~120min;
The concentration is is concentrated in vacuo;
The temperature of the concentration is 30~70 DEG C.
Preferably, a concentration of 50%-98% of the edible alcohol;
The moisturizer is one or more in glycerine, panthenol and propylene glycol.
Preferably, the active constituent stabilizer is Tween-80 and/or rilanit special;
The surfactant is lauryl glucosyl and/or poloxamer188.
Preferably, the essence is one or more in Peppermint essential oil, lemon and orange flavor.
Preferably, the sweetener is one or more in saccharin sodium, xylitol and D-sorbite.
The present invention also provides a kind of preparation methods of the mouthwash containing vine tea flavone extract, include the following steps:
Vine tea flavone extract, menthol and edible alcohol are added into moisturizer after mixing, active constituent is stablized
Agent, surfactant, essence, sweetener, preservative and water, heating stirring, after obtaining clear solution, cooling stands filtering, removes
Filter residue is removed, obtains the mouthwash containing vine tea flavone extract;
Wherein, vine tea flavone extract, menthol, edible alcohol, moisturizer, active constituent stabilizer, surfactant,
The weight percent of essence, sweetener and preservative is 0.1%~1%:0.01%~0.15%:1%~10%:1%~
10%:0.1%~1%:0.1%~0.5%:0.1%~0.8%:0.01%~0.15%:0.01%~0.5%, surplus is
Water.
Preferably, the temperature of the heating stirring is 25~100 DEG C.
In conclusion the present invention provides a kind of mouthwash containing vine tea flavone extract, by vine tea flavone extract,
Menthol, edible alcohol, moisturizer, active constituent stabilizer, surfactant, essence, sweetener, preservative and water are made,
Vine tea flavone extract is active components of plants, has the effects that antibacterial, anti-inflammatory, hemostasis, deodorization, which can clean mouth
Chamber, fresh breath, also, the mouthwash multiple efficacies, the long-time service such as has antibacterial, anti-inflammatory concurrently, stops blooding, wets one's whistle and can effectively prevent
Canker sore, sphagitis, periodontitis, the mouthwash can be used for a long time, have no toxic side effect.
Specific embodiment
The present invention provides a kind of mouthwash containing vine tea flavone extract, is not suitable for for a long time for solving existing mouthwash
The problem of being used as oral care.
The technical solution in the present invention will be clearly and completely described below, it is clear that described embodiment is only
It is part of the embodiment of the present invention, instead of all the embodiments.Based on the embodiments of the present invention, ordinary skill people
Member's all other embodiments obtained without making creative work, shall fall within the protection scope of the present invention.
A kind of mouthwash containing vine tea flavone extract, by weight percentage, is made of following components:
Vine tea also known as ampelopsis grossdentata are a kind of perennial lianas, are distributed widely in drought, such as wide
The ground such as west, Guangdong, Gansu, Shaanxi, Guizhou.It is a kind of ancient medical and edible dual purpose plant, and complete stool all has medical value, has
Clearing heat and detoxicating, inhibiting bacteria and diminishing inflammation and other effects is usually used in treating the diseases such as cold, fever, abscess of throat, canker sore.It is tender in the children of vine tea
In cauline leaf, flavones ingredient accounts for the 35%~45% of dry weight, is the principle active component in vine tea.
Mouthwash of the present invention is by vine tea flavone extract, menthol, edible alcohol, moisturizer, active constituent stabilizer, table
Face activating agent, essence, sweetener, preservative and water are made, vine tea flavone extract be active components of plants, have it is antibacterial, disappear
The effects that scorching, hemostasis, deodorization, the mouthwash can clean oral cavity, fresh breath, also, the mouthwash have concurrently antibacterial, anti-inflammatory,
Multiple efficacies, the long-time service such as stop blooding, wet one's whistle can effectively prevent canker sore, sphagitis, periodontitis, the mouthwash alcohol content
It is low, and the active components of plants long-term consumption added has no toxic side effect, therefore, mouthwash of the present invention can be used for a long time, nontoxic pair
Effect.
In the present invention, the extracting method of vine tea flavone extract is as follows:
Vine tea powder in boiling water is extracted, obtains being concentrated again after extracting solution, dry, obtain vine tea flavone and carry
Take object.
Vine tea flavone extract of the present invention is extracted using hydro-thermal extraction method, and extraction equipment is simple, and process costs are low, peace
Entirely, it pollutes small.
In the present invention, the volume ratio of vine tea powder and boiling water is 1:5~20.
In the present invention, the time of extraction is 30~120min;
It concentrates to be concentrated in vacuo;
The temperature of concentration is 30~70 DEG C.
More specifically, the volume ratio of vine tea powder and boiling water is 1:10;The time of extraction is 60min;The temperature of concentration is
45℃。
In the present invention, a concentration of the 50%~98% of edible alcohol;
Moisturizer is one or more in glycerine, panthenol and propylene glycol.
In the present invention, active constituent stabilizer is Tween-80 and/or rilanit special;
Surfactant is lauryl glucosyl and/or poloxamer188.
In the present invention, essence is one or more in Peppermint essential oil, lemon and orange flavor.
Sweetener is one or more in saccharin sodium, xylitol and D-sorbite.
In the present invention, the concentration of edible alcohol is more specifically 95%;Preservative is more specifically sodium benzoate;Water is more specifically
Deionized water.
The present invention also provides a kind of preparation methods of the mouthwash containing vine tea flavone extract, include the following steps:
Vine tea flavone extract, menthol and edible alcohol are added into moisturizer after mixing, active constituent is stablized
Agent, surfactant, essence, sweetener, preservative and water, heating stirring, after obtaining clear solution, cooling stands filtering, removes
Filter residue is removed, obtains the mouthwash containing vine tea flavone extract;
Wherein, vine tea flavone extract, menthol, edible alcohol, moisturizer, active constituent stabilizer, surfactant,
The weight percent of essence, sweetener and preservative is 0.1%~1%:0.01%~0.15%:1%~10%:1%~
10%:0.1%~1%:0.1%~0.5%:0.1%~0.8%:0.01%~0.15%:0.01%~0.5%, surplus is
Water.
In the present invention, the temperature of heating stirring is 25~100 DEG C.
In the present invention, cooling stands filtering, can remove the impurity in vine tea flavone extract;The temperature of heating stirring is
At 25~100 DEG C, system can be dissolved, obtain clear solution, and can guarantee the activity of vine tea flavone extract not by broken
Ring.
In the present invention, mouthwash stable system, mouthwash preparation method is simple, is easy to industrialized production, can be applicable.
For a further understanding of the present invention, with reference to specific embodiment, the present invention will be described in detail.
Embodiment 1
The vine tea dried is crushed to obtain vine tea powder, vine tea powder extracts in boiling water, vine tea powder and boiling water
Volume ratio be 1:10, extraction time 60min obtain being concentrated in vacuo at 45 DEG C again after extracting solution, dry, obtain rattan
Tea chromocor extract.
Vine tea flavone extract, menthol and 95% edible alcohol are added into moisturizer, active constituent after mixing
Stabilizer, surfactant, essence, sweetener, preservative and deionized water, heating stirring, after obtaining clear solution, cooling,
Filtering is stood, filter residue is removed, obtains the mouthwash containing vine tea flavone extract;
Wherein, vine tea flavone extract, menthol, 95% edible alcohol, moisturizer, active constituent stabilizer, surface are lived
Property agent, essence, sweetener and preservative weight percent be 0.1%:0.05%:2%:5.5%:0.5%:0.1%:
0.15%:0.01%:0.1%, surplus is deionized water.
Embodiment 2
The vine tea dried is crushed to obtain vine tea powder, vine tea powder extracts in boiling water, vine tea powder and boiling water
Volume ratio be 1:10, extraction time 60min obtain being concentrated in vacuo at 45 DEG C again after extracting solution, dry, obtain rattan
Tea chromocor extract.
Vine tea flavone extract, menthol and 95% edible alcohol are added into moisturizer, active constituent after mixing
Stabilizer, surfactant, essence, sweetener, preservative and deionized water, heating stirring, after obtaining clear solution, cooling,
Filtering is stood, filter residue is removed, obtains the mouthwash containing vine tea flavone extract;
Wherein, vine tea flavone extract, menthol, 95% edible alcohol, moisturizer, active constituent stabilizer, surface are lived
Property agent, essence, sweetener and preservative weight percent be 0.3%:0.08%:3%:5.5%:1%:0.4%:
0.28%:0.03%:0.1%, surplus is deionized water.
Embodiment 3
The vine tea dried is crushed to obtain vine tea powder, vine tea powder extracts in boiling water, vine tea powder and boiling water
Volume ratio be 1:10, extraction time 60min obtain being concentrated in vacuo at 45 DEG C again after extracting solution, dry, obtain rattan
Tea chromocor extract.
Vine tea flavone extract, menthol and 95% edible alcohol are added into moisturizer, active constituent after mixing
Stabilizer, surfactant, essence, sweetener, preservative and deionized water, heating stirring, after obtaining clear solution, cooling,
Filtering is stood, filter residue is removed, obtains the mouthwash containing vine tea flavone extract;
Wherein, vine tea flavone extract, menthol, 95% edible alcohol, moisturizer, active constituent stabilizer, surface are lived
Property agent, essence, sweetener and preservative weight percent be 1%:0.12%:5%:5.5%:1%:0.5%:0.52%:
0.1%:0.1%, surplus is deionized water.
Embodiment 4
The present embodiment makees the anti-recurrence stomatocace of vine tea flavone extract using stomatocace model
With being studied.
48 rats, 165~200g of weight are taken, half male and half female is randomly divided into six groups, every group 8 by gender, weight.Six
Group is respectively control group, model group and four groups of vine tea flavone extract groups, in addition to control group, the depilation of rat both sides, and ethanol disinfection,
Immunizing antigen is made with Freund's complete adjuvant using the homogenate of allogeneic mucous membrane of mouth, both sides respectively take at 1 point at depilation, note respectively
Immunizing antigen 0.1mL is penetrated, biweekly, totally five times, control rats are by method of the same race injection control matrix.5th injection is exempted from
Start to be administered while epidemic disease antigen.To distilled water, four groups of vine tea flavone extract components Gei not vine tea Huang for control group and model group
By 10mL/kg gastric infusion 7d, preceding and administration phase is administered in ketone extract 25mg/kg, 50mg/kg, 100mg/kg and 150mg/kg
Between observe canker sore frequency.
Experimental result is found:After third time inoculation, in addition to control group, there is ulcer in rat mucous membrane of mouth, every
How much the number that rat ulcer occurs differs;It is recurred again after ulcer healing;Before administration, each group rat canker sore frequency
No difference of science of statistics.After administration, compared with model group, ulcer frequency can be reduced to vine tea flavone extract 25mg/kg, but
It is not statistically significant, it can significantly reduce ulcer generation time to vine tea flavone extract 50mg/kg, 100mg/kg and 200mg/kg
Number.The experimental results showed that vine tea flavone extract has the function of anti-recurrence stomatocace.
The effective ingredient of mouthwash of the present invention containing vine tea flavone extract is vine tea flavone extract, and vine tea flavone carries
It takes object that there is anti-recurrence stomatocace, reduces ulcer frequency.
The above is only the preferred embodiment of the present invention, it is noted that for the ordinary skill people of the art
For member, various improvements and modifications may be made without departing from the principle of the present invention, these improvements and modifications also should
It is considered as protection scope of the present invention.
Claims (10)
1. a kind of mouthwash containing vine tea flavone extract, which is characterized in that by weight percentage, by following components system
Into:
2. mouthwash according to claim 1, which is characterized in that the extracting method of the vine tea flavone extract is as follows:
Vine tea powder in boiling water is extracted, obtains being concentrated again after extracting solution, dry, obtains vine tea flavone extraction
Object.
3. mouthwash according to claim 2, which is characterized in that the volume ratio of the vine tea powder and boiling water is 1:5~
20。
4. mouthwash according to claim 2, which is characterized in that the time of the extraction is 30~120min;
The concentration is is concentrated in vacuo;
The temperature of the concentration is 30~70 DEG C.
5. mouthwash according to claim 1, which is characterized in that a concentration of 50%-98% of the edible alcohol;
The moisturizer is one or more in glycerine, panthenol and propylene glycol.
6. mouthwash according to claim 1, which is characterized in that the active constituent stabilizer is Tween-80 and/or hydrogen
Change castor oil;
The surfactant is lauryl glucosyl and/or poloxamer188.
7. mouthwash according to claim 1, which is characterized in that the essence is Peppermint essential oil, lemon and sweet orange
It is one or more in essence.
8. mouthwash according to claim 1, which is characterized in that the sweetener is saccharin sodium, xylitol and sorbose
It is one or more in alcohol.
9. a kind of preparation method of the mouthwash containing vine tea flavone extract, which is characterized in that include the following steps:
Vine tea flavone extract, menthol and edible alcohol are added into moisturizer, active constituent stabilizer, table after mixing
Face activating agent, essence, sweetener, preservative and water, heating stirring, after obtaining clear solution, cooling stands filtering, removes filter
Slag obtains the mouthwash containing vine tea flavone extract;
Wherein, vine tea flavone extract, menthol, edible alcohol, moisturizer, active constituent stabilizer, surfactant, perfume (or spice)
The weight percent of essence, sweetener and preservative is 0.1%~1%:0.01%~0.15%:1%~10%:1%~10%:
0.1%~1%:0.1%~0.5%:0.1%~0.8%:0.01%~0.15%:0.01%~0.5%, surplus is water.
10. preparation method according to claim 9, which is characterized in that the temperature of the heating stirring is 25~100 DEG C.
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Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN113197803A (en) * | 2021-04-29 | 2021-08-03 | 浙江吉叶生物科技有限公司 | Antibacterial mouth wash and preparation method thereof |
CN115363979A (en) * | 2021-05-21 | 2022-11-22 | 湖北工业大学 | Mouth wash containing dihydromyricetin and preparation method thereof |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101627965A (en) * | 2009-07-21 | 2010-01-20 | 清华大学 | Multifunctional pure natural mouthwash and preparation method thereof |
CN102058532A (en) * | 2010-12-30 | 2011-05-18 | 张家界茅岩莓有限公司 | Compound dihydromyricetin oral aerosol and preparation method thereof |
CN103263375A (en) * | 2013-05-30 | 2013-08-28 | 云南七丹药业股份有限公司 | Mouthrinse containing extract and preparation method of mouthrinse |
CN106727014A (en) * | 2017-01-05 | 2017-05-31 | 佛山市恒南医药科技有限公司 | A kind of compound of wild rattan mother-in-law tea extraction and its application |
CN107349155A (en) * | 2017-08-25 | 2017-11-17 | 河北聚泽医疗器械有限公司 | Mouthwash |
-
2018
- 2018-03-05 CN CN201810180008.9A patent/CN108158899A/en active Pending
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101627965A (en) * | 2009-07-21 | 2010-01-20 | 清华大学 | Multifunctional pure natural mouthwash and preparation method thereof |
CN102058532A (en) * | 2010-12-30 | 2011-05-18 | 张家界茅岩莓有限公司 | Compound dihydromyricetin oral aerosol and preparation method thereof |
CN103263375A (en) * | 2013-05-30 | 2013-08-28 | 云南七丹药业股份有限公司 | Mouthrinse containing extract and preparation method of mouthrinse |
CN106727014A (en) * | 2017-01-05 | 2017-05-31 | 佛山市恒南医药科技有限公司 | A kind of compound of wild rattan mother-in-law tea extraction and its application |
CN107349155A (en) * | 2017-08-25 | 2017-11-17 | 河北聚泽医疗器械有限公司 | Mouthwash |
Non-Patent Citations (1)
Title |
---|
韦庆益等: "《食品生物化学实验》", 29 February 2012, 华南理工大学出版社 * |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN113197803A (en) * | 2021-04-29 | 2021-08-03 | 浙江吉叶生物科技有限公司 | Antibacterial mouth wash and preparation method thereof |
CN113197803B (en) * | 2021-04-29 | 2022-04-19 | 浙江吉叶生物科技有限公司 | Antibacterial mouth wash and preparation method thereof |
CN115363979A (en) * | 2021-05-21 | 2022-11-22 | 湖北工业大学 | Mouth wash containing dihydromyricetin and preparation method thereof |
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