CN102058532A - Compound dihydromyricetin oral aerosol and preparation method thereof - Google Patents
Compound dihydromyricetin oral aerosol and preparation method thereof Download PDFInfo
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- CN102058532A CN102058532A CN2010106123026A CN201010612302A CN102058532A CN 102058532 A CN102058532 A CN 102058532A CN 2010106123026 A CN2010106123026 A CN 2010106123026A CN 201010612302 A CN201010612302 A CN 201010612302A CN 102058532 A CN102058532 A CN 102058532A
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Abstract
The invention discloses a compound dihydromyricetin oral aerosol and a preparation method thereof. The aerosol is prepared by mixing the following raw materials in percentage by weight: 98 percent of water extract of dihydromyricetin, 0.05 to 1 percent of deodorant and 0.1 to 1.5 percent of flavoring agent; and the preparation method comprises the following steps of: mixing the water extract of dihydromyricetin, the deodorant and the flavoring agent, uniformly stirring, performing nanofiltration and filling, wherein the deodorant comprises sodium copper chlorophyllin and a tea extract; the flavoring agent comprises natural menthol or 1 to 3 kinds of fruity flavors; and the tea extract is tea polyphenol or catechin. The dihydromyricetin extract is refined through a modern extraction, separation and purification process, and is compounded into the oral aerosol which has the effects of inhibiting bacteria, diminishing inflammation, stopping bleeding, wetting throat, deodorizing and the like and has good mouthfeel without peculiar smell or side effect. Moreover, the oral aerosol has health care effect on the mouth, teeth and throat, and has the effects of preventing and treating pharyngitis, periodontitis, gingivitis, dental ulcer, tooth decay and the like.
Description
Technical field
The present invention relates to field of health care products, specifically, providing a kind of dihydromyricetin water extract that extracts with Ampelopsis grossedentata is oral spray of major ingredient preparation and preparation method thereof.
Background technology
As the saying goes " illness finds its way in by the mouth ", human oral cavity is because of breathing and mouth is chewed the residual of food, become many vegetative hotbeds such as streptococcus, staphylococcus, cause, have a strong impact on the healthy of people as multiple diseases such as oral ulcer, dental caries, pharyngolaryngitis and upper respiratory tract infection.Particularly along with modern people's doings increase, boil on the nape opposite the mouth accent gas is paid attention to more, and oral hygiene becomes the important door of prevention and treatment disease.
Ampelopsis grossedentata is a kind of wild liana class tea plant in the Vitaceae Ampelopsis, also be ethnic groups a kind of medicine-food two-purpose Chinese herbal medicines commonly used such as China south Tujia, the Yao nationality, among the peoplely its young stem and leaf is made health teas such as " mould tea ", " Ampelopsis grossedentata ", be used for the treatment of diseases such as heating, laryngopharynx swelling and pain, chronic pharyngitis, oral ulcer, Jaundice Jaundice, the use history in existing hundreds of years.Flavonoid content is up to 41.2～45.4% in the ground Ampelopsis grossedentata stem and leaf dries such as Zhangjiajie, Hunan, Jiang Hua according to surveying and determination, and the dihydromyricetin cellulose content reaches 27.8～31.2%, is the main functional component of such health tea.
Dihydromyricetin (3,5,7,3 ', 4 ', 5 '-hexahydroxy-2, the 3-flavanonol, Dihydromyricetin DMY) claims ampelopsin again, is a kind of active skull cap components, belong to the polyhydroxy flavanonol, existing documents and materials confirm to have multiple pharmacologically active, as antiinflammatory, analgesia, blood pressure lowering, blood fat reducing, antitumor and hepatoprotective, alleviate ethylism etc., and nontoxic substantially to human body.The Ampelopsis grossedentata total flavone buccal tablet of domestic existing treatment oral ulcer is put on market, but bioavailability is low, and particularly infant uses inconvenient.
Oral spray is as a novel form of modern pharmaceutical, it is convenient to have route of administration, and drug absorption is rapid-action soon, characteristics such as drug bioavailability height, also can reduce medicine to the gastrointestinal side effect, will become the main flow dosage form that adapts to modern crowd's oral hygiene health demand.
Summary of the invention
The object of the present invention is to provide a kind of dihydromyricetin water extract that extracts with Ampelopsis grossedentata is main composite oral spray, has antibacterial, antiinflammatory, stops blooding, wets one's whistle, multiple efficacies such as deodorize, easy to use.Another object of the present invention is to provide a kind of preparation method of compound recipe dihydromyricetin oral spray.
Technical scheme of the present invention is: a kind of compound recipe dihydromyricetin oral spray, it is characterized in that, form by following raw materials by weight percent mixed preparing: dihydromyricetin water extract 98%, deodorant 0.05～1%, correctives 0.1～1.5%, preparation method is that dihydromyricetin water extract, deodorant and correctives are mixed, stir, fill after the nanofiltration, described deodorant comprises Sodium Copper Chlorophyllin and Folium Camelliae sinensis extract, correctives comprises Natural menthol or 1～3 kind of fruit flavors, and described Folium Camelliae sinensis extract is tea polyphenols or catechin.
Containing dihydromyricetin concentration in the described dihydromyricetin water extract is 50mg/ml.
The preparation method of described dihydromyricetin water extract is: the Ampelopsis grossedentata raw material is put into extraction pot, with the pure water is to extract medium, feed liquid weight ratio 1: 12 is extracted 90～95 ℃ of temperature, extraction time 2h, extract 2 times continuously, merging filtrate micropore fine straining, fine straining liquid are crossed the decolouring of 100000Da rolling ultrafilter membrane earlier, and dialysis solution is after 500Da rolling NF membrane, the nanofiltration trapped fluid adds 3% active carbon and concentrates decolouring again, promptly gets dihydromyricetin water extract behind the fine straining.
Described Ampelopsis grossedentata raw material is about 1 month young young stem and leaf of Ampelopsis grossedentata new germination and growth in the beginning of spring that drying is handled.
The compound recipe dihydromyricetin oral spray of the present invention's allotment adopts the aerosol PACKAGING BY POLYESTER BOTTLES, and 20～200ml/ bottle plurality of specifications is arranged.
The present invention takes safely and effectively on " mould tea " processing technology basis for a long time the local ethnic groups crowd of succession, in conjunction with inventor's years of researches achievement, adopt modern process for extracting, separating and purifying to be refined into the dihydromyricetin extracting solution, be re-dubbed oral spray again, have antibacterial, antiinflammatory concurrently, stop blooding, wet one's whistle, multiple efficacies such as deodorize, mouthfeel is good, and free from extraneous odour has no side effect.Boil on the nape opposite the mouth, tooth, larynx have the health care effect, and pharyngolaryngitis, periodontitis, gingivitis, oral ulcer, dental caries etc. are had prevention and therapeutical effect.
The specific embodiment
Provide the preferred case study on implementation in the scope of the invention below.
Embodiment 1:
Prescription (by weight): dihydromyricetin water extract 9800g, Natural menthol 150g and tea polyphenols 50g.It is 50mg/ml that dihydromyricetin water extract includes the dihydromyricetin water concentration.Tea polyphenols is a food stage, purity＞90%.
The manufacture method of the compound oral spray of above-mentioned prescription is as follows:
Herba Menthae, tea polyphenols are put into dihydromyricetin water extract stir, after the nanofiltration fill in 50ml aerosol polyester bottles, seal, pack, be after the assay was approved finished product.
The preparation method of above-mentioned dihydromyricetin water extract is: the Ampelopsis grossedentata raw material is put into extraction pot, with the pure water is to extract medium, feed liquid weight ratio 1: 12 is extracted 90～95 ℃ of temperature, extraction time 2h, extract 2 times continuously, merging filtrate micropore fine straining, fine straining liquid are crossed the decolouring of 100000Da rolling ultrafilter membrane earlier, and dialysis solution is after 500Da rolling NF membrane, the nanofiltration trapped fluid adds 3% active carbon and concentrates decolouring again, promptly gets dihydromyricetin water extract behind the fine straining.
Above-mentioned employed Ampelopsis grossedentata raw material, acquisition time is the 5-6 month, and the feedstock capture position is about 1 month young young stem and leaf of Ampelopsis grossedentata new germination and growth in the beginning of spring, and the bright leaf of plucking the same day requires oven dry to preserve.
Embodiment 2:
Prescription (by weight): dihydromyricetin water extract 9800g, Fructus Citri Limoniae essence 100g and Sodium Copper Chlorophyllin 100g.It is 50mg/ml that dihydromyricetin water extract includes the dihydromyricetin water concentration.The preparation method of dihydromyricetin water extract is identical with embodiment 1.
The manufacture method of the compound oral spray of above-mentioned prescription is as follows:
Fructus Citri Limoniae essence, Sodium Copper Chlorophyllin are put into dihydromyricetin water extract stir, after the nanofiltration fill in 100ml aerosol polyester bottles, seal, pack, be after the assay was approved finished product.
Embodiment 3:
Prescription (by weight): dihydromyricetin water extract 9800g, Oleum Menthae Rotundifoliae 50g, strawberry essence 100g and catechin 50g.It is 50mg/ml that dihydromyricetin water extract includes the dihydromyricetin water concentration.The preparation method of dihydromyricetin water extract is identical with embodiment 1.
The manufacture method of the compound oral spray of above-mentioned prescription is as follows:
Oleum Menthae Rotundifoliae, strawberry essence, catechin are put into dihydromyricetin water extract stir, after the nanofiltration fill 50ml in the aerosol polyester bottles, seal, pack, be after the assay was approved finished product.
Claims (7)
1. compound recipe dihydromyricetin oral spray, it is characterized in that, formulated by following raw materials by weight percent: dihydromyricetin water extract 98%, deodorant 0.05～1%, correctives 0.1～1.5%, preparation method is that dihydromyricetin water extract, deodorant and correctives are mixed, stir, fill after the nanofiltration, described deodorant comprises Sodium Copper Chlorophyllin and Folium Camelliae sinensis extract, correctives comprises Natural menthol or 1～3 kind of fruit flavors, and described Folium Camelliae sinensis extract is tea polyphenols or catechin.
2. compound recipe dihydromyricetin oral spray according to claim 1 is characterized in that, containing dihydromyricetin concentration in the described dihydromyricetin water extract is 50mg/ml.
3. described compound recipe dihydromyricetin oral spray according to claim 1 is characterized in that proportioning raw materials is: dihydromyricetin water extract 9800g, Natural menthol 150g and tea polyphenols 50g.
4. described compound recipe dihydromyricetin oral spray according to claim 1 is characterized in that described fruity flavor is a Fructus Citri Limoniae essence, and proportioning raw materials is: dihydromyricetin water extract 9800g, Fructus Citri Limoniae essence 100g and Sodium Copper Chlorophyllin 100g.
5. described compound recipe dihydromyricetin oral spray according to claim 1, it is characterized in that, described fruity flavor is Oleum Menthae Rotundifoliae and strawberry essence, and proportioning raw materials is: dihydromyricetin water extract 9800g, Oleum Menthae Rotundifoliae 50g, strawberry essence 100g and catechin 50g.
6. described compound recipe dihydromyricetin oral spray according to claim 1, it is characterized in that, the preparation method of described dihydromyricetin water extract is: the Ampelopsis grossedentata raw material is put into extraction pot, with the pure water is to extract medium, feed liquid weight ratio 1: 12, extract 90～95 ℃ of temperature, extraction time 2h, extract 2 times continuously, merging filtrate micropore fine straining, fine straining liquid are crossed the decolouring of 100000Da rolling ultrafilter membrane earlier, and dialysis solution is after 500Da rolling NF membrane, the nanofiltration trapped fluid adds 3% active carbon and concentrates decolouring again, promptly gets dihydromyricetin water extract behind the fine straining.
7. the preparation method of a compound recipe dihydromyricetin oral spray as claimed in claim 1, it is characterized in that, with dihydromyricetin water extract, deodorant and correctives mix, stir, fill after the nanofiltration, the preparation method of described dihydromyricetin water extract is: the Ampelopsis grossedentata raw material is put into extraction pot, with the pure water is to extract medium, feed liquid weight ratio 1: 12, extract 90～95 ℃ of temperature, extraction time 2h extracts 2 times continuously, merging filtrate micropore fine straining, fine straining liquid is crossed the decolouring of 100000Da rolling ultrafilter membrane earlier, dialysis solution is after 500Da rolling NF membrane, and the nanofiltration trapped fluid adds 3% active carbon and concentrates decolouring again, promptly gets dihydromyricetin water extract behind the fine straining.
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Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103238391A (en) * | 2013-05-24 | 2013-08-14 | 广东省农业科学院水稻研究所 | Application of vine tea extract in improving germination rate of deteriorated seeds of rice |
| CN103265367A (en) * | 2013-05-24 | 2013-08-28 | 广东省农业科学院水稻研究所 | Mixed type agent for restoring activity of deteriorated rice seed embryo, preparation method and application of mixed type agent |
| WO2014044836A1 (en) * | 2012-09-21 | 2014-03-27 | Nestec S.A. | Plant phenols and their use in the treatment or prevention of eosinophilic esophagitis |
| CN106310236A (en) * | 2016-08-29 | 2017-01-11 | 陈石良 | Antioxidation SOD oral spray and preparing method thereof |
| CN108158899A (en) * | 2018-03-05 | 2018-06-15 | 广东工业大学 | A kind of mouthwash containing vine tea flavone extract and preparation method thereof |
| CN108379138A (en) * | 2018-03-05 | 2018-08-10 | 广东工业大学 | A kind of flavorants and preparation method thereof containing vine tea flavone extract |
| CN110934159A (en) * | 2019-12-24 | 2020-03-31 | 贵州贵安精准医学研究院股份有限公司 | Development and application of natural bactericidal spray |
| CN113288955A (en) * | 2021-06-04 | 2021-08-24 | 贵州中医药大学 | Spray and preparation method and application thereof |
| CN114432278A (en) * | 2022-03-08 | 2022-05-06 | 陕西科技大学 | Dihydromyricetin quick-acting alcohol-dispelling orally-dissolving film agent and preparation method and application thereof |
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| US10548873B2 (en) | 2012-09-21 | 2020-02-04 | Societe Des Produits Nestle S.A. | Plant phenols and their use in the treatment or prevention of eosinophilic esophagitis |
| CN104640539B (en) * | 2012-09-21 | 2019-08-02 | 雀巢产品有限公司 | Plant phenols and its purposes in treatment or prevention eosinophilic esophagitis |
| US11382891B2 (en) | 2012-09-21 | 2022-07-12 | Societe Des Produits Nestle S.A. | Plant phenols and their use in the treatment or prevention of eosinophilic esophagitis |
| CN110292592A (en) * | 2012-09-21 | 2019-10-01 | 雀巢产品有限公司 | Plant phenols and its purposes in treatment or prevention eosinophilic esophagitis |
| AU2013320148B2 (en) * | 2012-09-21 | 2018-05-10 | Société des Produits Nestlé S.A. | Plant phenols and their use in the treatment or prevention of eosinophilic esophagitis |
| CN104640539A (en) * | 2012-09-21 | 2015-05-20 | 雀巢产品技术援助有限公司 | Plant phenols and their use in the treatment or prevention of eosinophilic esophagitis |
| WO2014044836A1 (en) * | 2012-09-21 | 2014-03-27 | Nestec S.A. | Plant phenols and their use in the treatment or prevention of eosinophilic esophagitis |
| CN103265367B (en) * | 2013-05-24 | 2015-07-22 | 广东省农业科学院水稻研究所 | Mixed type agent for restoring activity of deteriorated rice seed embryo, preparation method and application of mixed type agent |
| CN103265367A (en) * | 2013-05-24 | 2013-08-28 | 广东省农业科学院水稻研究所 | Mixed type agent for restoring activity of deteriorated rice seed embryo, preparation method and application of mixed type agent |
| CN103238391B (en) * | 2013-05-24 | 2015-05-06 | 广东省农业科学院水稻研究所 | Application of vine tea extract in improving germination rate of deteriorated seeds of rice |
| CN103238391A (en) * | 2013-05-24 | 2013-08-14 | 广东省农业科学院水稻研究所 | Application of vine tea extract in improving germination rate of deteriorated seeds of rice |
| CN106310236A (en) * | 2016-08-29 | 2017-01-11 | 陈石良 | Antioxidation SOD oral spray and preparing method thereof |
| CN108379138A (en) * | 2018-03-05 | 2018-08-10 | 广东工业大学 | A kind of flavorants and preparation method thereof containing vine tea flavone extract |
| CN108158899A (en) * | 2018-03-05 | 2018-06-15 | 广东工业大学 | A kind of mouthwash containing vine tea flavone extract and preparation method thereof |
| CN110934159A (en) * | 2019-12-24 | 2020-03-31 | 贵州贵安精准医学研究院股份有限公司 | Development and application of natural bactericidal spray |
| CN113288955A (en) * | 2021-06-04 | 2021-08-24 | 贵州中医药大学 | Spray and preparation method and application thereof |
| CN114432278A (en) * | 2022-03-08 | 2022-05-06 | 陕西科技大学 | Dihydromyricetin quick-acting alcohol-dispelling orally-dissolving film agent and preparation method and application thereof |
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