CN105310960B - A kind of novel polysaccharide antimicrobial mouthwash and preparation method thereof - Google Patents
A kind of novel polysaccharide antimicrobial mouthwash and preparation method thereof Download PDFInfo
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- CN105310960B CN105310960B CN201510731042.7A CN201510731042A CN105310960B CN 105310960 B CN105310960 B CN 105310960B CN 201510731042 A CN201510731042 A CN 201510731042A CN 105310960 B CN105310960 B CN 105310960B
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- propolis
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- carboxymethyl chitosan
- purified water
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/736—Chitin; Chitosan; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/733—Alginic acid; Salts thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
- A61K8/987—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of species other than mammals or birds
- A61K8/988—Honey; Royal jelly, Propolis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/52—Stabilizers
Abstract
The invention discloses a kind of novel polysaccharide antimicrobial mouthwash and preparation method thereof.The effective ingredient of the gargle is carboxymethyl chitosan and propolis, in addition to the concentrated liquid of tradition Chinese medicine, sodium alginate, peppermint oil, acid-base modifier, ethanol and purified water.Its preparation method is to take purified water, adds carboxymethyl chitosan and propolis ethanol solution according to quantity, and heating makes dissolving;It is to be cooled, Chinese herbal medicine concentrate, sodium alginate, peppermint oil, acidity-basicity regulator are added, purified water is added to full dose, product is obtained after determining pH value.The present invention has the effect of cleaning oral cavity, antibacterial shield tooth, while reduces allergy risk caused by propolis, and carries a kind of very unique Chinese herbal medicine fragrance, does not add any compound essence, more safe and healthy.Preparation method of the present invention is simple, and cost is cheap, and durable antibacterial effect is effective, and human body is had no toxic side effect, comfortable taste.
Description
Technical field
The invention belongs to medical health product field, more particularly to a kind of novel polysaccharide antimicrobial mouthwash and preparation method thereof.
Background technology
In recent years, the incidence of disease of stomatopathy is high, with the raising of living standards of the people and health perception, oral disease
Preventing and treating and the protection of tooth are more and more important, traditional oral care means for being brushed teeth using toothpaste exist in-convenience in use, clearly
Reason not in time, not thoroughly, to tooth have abrasion etc. drawback, it is difficult to meet the oral cleaning requirement of people.
Mouth disease is a kind of common disease, is mainly shown as gingivitis, bacterial plaque, canker sore, periodontitis, dispute life
The symptoms such as sore, halitosis.After harmful bacteria enters blood caused by mouth disease, different degrees of shadow can be produced to whole body health
Ring, or even the Important cause of disease as some general diseases.Modern medicine study shows, mouth disease and internal system, painstaking effort
Guard system and respiratory system etc. have close relationship.People also already prevent oral cavity disease by various oral care products
The generation of disease.At present, the major product in terms of detergents and cosmetic oral care can be divided into toothpaste, gargle and flavorants,
These products mainly play cleaning tooth, tooth-whitening, remove dental plaque, kill oral cavity harmful bacteria, pre- anti-caries, fresh breath etc.
Effect, while the treatment to some mouth diseases such as such as various focusing depths representeds also functions to certain positive role.Also some other is such as
The chewing gum of foodstuff, edible implication cleaning sheet etc. also have more or less prevention effect.
Gargle is generally seated in portable Packaging Bottle, can entered at any time as a kind of emerging oral cavity cleaning and nursing product
Exercise and use, thoroughly overcome oral care not in time, toothpaste in-convenience in use, the cleaning drawback such as not thorough, it cleans oral cavity, pre-
The effect such as anti-caries and periodontitis is significantly stronger than conventional toothpaste, and then very popular in recent years.It is made in the present invention
Before, the product such as existing water soluble chitosan gargle, Tea Polyphenols gargle clinically uses, but because of itself fungistatic effect list
One, it is higher to concentration requirement, or need to be acted synergistically with high concentration ethanol and get to fungistatic effect, so that narrow antimicrobial spectrum, is used
Effect is poor, and mouthfeel is bad, the reasons such as patient is difficult to receive, and causes to be difficult to popularization and application.
Propolis because have the characteristics that broad-spectrum antiseptic, anti-mildew change and it is antiviral, as a kind of natural antibiotics, applied
Into tooth paste product.But propolis raw material complicated component, the people of allergic constitution easily occur allergic reaction and not can determine that allergy
Source, in addition propolis extraction process be not easy to supervise, content of beary metal is generally exceeded in the propolis of actual use, and propolis is in itself
It is acidulous material and is rich in estrogen substance, has certain dissolution to enamel, the calcium dissolution in tooth can be caused.Gargle
For oral fluid because its occupation mode is different with toothpaste, the ratio swallowed into by human body is higher than toothpaste, therefore, is used in gargle
Propolis will more be focused on being formulated, make every effort to play propolis the advantages of and make up propolis shortcoming, make its performance in rinse product more
The effect of good.
The content of the invention
It is an object of the invention to overcome the deficiencies of the prior art and provide one kind containing natural antibacterial ingredient, without synthesis
Essence, retentiveness is good, can broad-spectrum antiseptic, durable antibacterial effect is effective, and human body is had no toxic side effect, and comfortable taste is gargled
Liquid;Meanwhile the present invention also provides a kind of preparation method of the gargle.
Novel polysaccharide antimicrobial mouthwash provided by the invention, its constituent mass percentage composition are:
Carboxymethyl chitosan:1~3%
Propolis:1~5%
Chinese herbal medicine concentrate:0.5~1%
Sodium alginate:0.2~0.5%
Peppermint oil:0.01~0.05%
Acid-base modifier:0.1~0.5%
Ethanol:5~15%
Surplus is purified water,
Wherein described the concentrated liquid of tradition Chinese medicine is with 10~15 parts by weight honeysuckles, 13~17 parts by weight chrysanthemum indicums, 12~18 weights
Amount part corydalis tuber, 12~18 parts by weight green tea, 3~7 parts by weight asarums are bulk drug, and every ml made of water boiling concentration contains crude drug 0.5
~1.5mg the concentrated liquid of tradition Chinese medicine.
Novel polysaccharide antimicrobial mouthwash as described above and preparation method thereof, comprises the following steps:
(1) carboxymethyl chitosan is added directly into dissolution kettle, dissolved with purified water, opened insulating box, be T in temperature
Mechanical agitation at=40~50 DEG C, until carboxymethyl chitosan all dissolves;
(2) it is added directly into after propolis is dissolved with ethanol in dissolution kettle, ensures that solution is in uniform state;
(3) it is 5.0~6.5 with the pH value of acid-base modifier regulating step (2) resulting solution;
(4) into step (3) resulting solution add Chinese herbal medicine concentrate, sodium alginate, peppermint oil, regulation temperature be 30~
40 DEG C, continue to be uniformly mixed;
(5) step (4) resulting solution is delivered into the next step packing, after detection meets product standard, packed,
Finished product is made.
Further, described acid-base modifier is one or both of calgon, sodium pyrophosphate.
Beneficial effects of the present invention are as follows:
1st, natural component, broad-spectrum antiseptic:The carboxymethyl chitosan of the present invention belongs to natural antimicrobial substance, and raw material is extensive, knot
Structure is clear and definite, and cost is cheap.Chitosan is a kind of more natural polysaccharide of Recent study, has unique molecular structure, is
Unique a large amount of existing basic amine group polysaccharide, have the effect of antibacterial in natural polysaccharide, it has also been found that chitosan and its spreading out
Biology has the effect of improving Chinese medicine preparation stability.Propolis not only contains abundant vitamin and a variety of nutritional trace elements,
And there is obvious antibacterial sterilization efficacy, it can suppress and kill various bacteria, virus etc..Use of the invention is more soluble in water
Carboxymethyl chitosan and propolis be used as main component, have and act synergistically, antibiotic effect can be strengthened, relative to other single shells
Glycan class gargle has excellent fungistatic effect.
2nd, it is safe and reliable, breath freshening:Present invention addition is entered with components such as honeysuckle, chrysanthemum indicum, corydalis tuber, asarum, green tea
The Chinese medicine extract of row compatibility, particularly asarum, it has antihistamine effect, there is significant relexation to tracheal smooth muscle,
It is added on a small quantity in the gargle of propolis-containing after above traditional Chinese medicine extraction, substantially increases using propolis and be used as the gargle of component
Security.But " there's no such thing as a totally safe medicine ", think that asarum is slightly poisonous on Chinese medicine, therefore can neither individually add in rinse product
Add, can not add excessively, the compatibility and addition of Chinese medicine extract provided by the invention can effectively solve asarum toxicity
Problem, make rinse product safe and reliable, while form a kind of very unique Chinese herbal medicine fragrance, as the fragrance of gargle,
Thus any compound essence is not added, it is more safe and healthy.
3rd, preparation method is simple, cost is cheap, is easy to carry:The liquid and preparation method thereof of gargling of the present invention is simple, and cost is cheap,
Durable antibacterial effect is effective, and human body is had no toxic side effect, and comfortable taste, is easy to carry, and suits large area to popularize and applies.
Embodiment
Below by way of specific embodiment further illustrate technical scheme, but technical scheme not with
Embodiment is limited.
Embodiment 1:
A kind of novel polysaccharide antimicrobial mouthwash and preparation method thereof, its preparation process are:
(1) 1% carboxymethyl chitosan is added directly into dissolution kettle, dissolved with purified water, insulating box is opened, in temperature
Spend for mechanical agitation at T=40~50 DEG C, until carboxymethyl chitosan all dissolves;
(2) it will be added directly into ethanol after 1% propolis dissolving in dissolution kettle, ensure that solution is in uniform state;
(3) it is 5.0~6.5 as the pH value of acid-base modifier regulating step (2) resulting solution by the use of calgon;
(4) 0.5% Chinese herbal medicine concentrate, 0.2% sodium alginate, 0.01% thin is added into step (3) resulting solution
Lotus oil, regulation temperature is 30~40 DEG C, continues to be uniformly mixed;
(5) step (4) resulting solution is delivered into the next step packing, after detection meets product standard, packed,
Finished product is made.
Chinese herbal medicine concentrate described in above-mentioned preparation method is 15 grams of extracting honeysuckle, 15 grams of chrysanthemum indicum, and 15 grams of corydalis tuber is green
15 grams of tea, 5 grams of asarum, add in 1.5 liters of purified waters, first decocted 20 minutes at 180 DEG C, decocted 40 minutes then at 110 DEG C, filtering
Obtain about 500 milliliters of filtrate.1.5 liters of deionized waters are added in the dregs of a decoction again, 180 DEG C decoct 15 minutes, and 110 DEG C decoct 30 minutes,
It is filtrated to get about 300 milliliters of filtrate.Merge filtrate twice, 110 DEG C are concentrated into 120 milliliters, and the concentrated liquid of tradition Chinese medicine is made, per ml containing life
0.5~1.5mg of medicine.
Embodiment 2:
A kind of novel polysaccharide antimicrobial mouthwash and preparation method thereof, its preparation process are:
(1) 2% carboxymethyl chitosan is added directly into dissolution kettle, dissolved with purified water, insulating box is opened, in temperature
Spend for mechanical agitation at T=40~50 DEG C, until carboxymethyl chitosan all dissolves;
(2) it will be added directly into ethanol after 3% propolis dissolving in dissolution kettle, ensure that solution is in uniform state;
(3) it is 5.0~6.5 as the pH value of acid-base modifier regulating step (2) resulting solution by the use of calgon;
(4) 0.5% Chinese herbal medicine concentrate, 0.2% sodium alginate, 0.01% thin is added into step (3) resulting solution
Lotus oil, regulation temperature is 30~40 DEG C, continues to be uniformly mixed;
(5) step (4) resulting solution is delivered into the next step packing, after detection meets product standard, packed,
Finished product is made.
Chinese herbal medicine concentrate described in above-mentioned preparation method is 15 grams of extracting honeysuckle, 15 grams of chrysanthemum indicum, and 15 grams of corydalis tuber is green
15 grams of tea, 5 grams of asarum, add in 1.5 liters of purified waters, first decocted 20 minutes at 180 DEG C, decocted 40 minutes then at 110 DEG C, filtering
Obtain about 500 milliliters of filtrate.1.5 liters of deionized waters are added in the dregs of a decoction again, 180 DEG C decoct 15 minutes, and 110 DEG C decoct 30 minutes,
It is filtrated to get about 300 milliliters of filtrate.Merge filtrate twice, 110 DEG C are concentrated into 120 milliliters, and the concentrated liquid of tradition Chinese medicine is made, per ml containing life
0.5~1.5mg of medicine.
Embodiment 3
A kind of novel polysaccharide antimicrobial mouthwash and preparation method thereof, its preparation process are:
(1) 3% carboxymethyl chitosan is added directly into dissolution kettle, dissolved with purified water, insulating box is opened, in temperature
Spend for mechanical agitation at T=40~50 DEG C, until carboxymethyl chitosan all dissolves;
(2) it will be added directly into ethanol after 5% propolis dissolving in dissolution kettle, ensure that solution is in uniform state;
(3) it is 5.0~6.5 as the pH value of acid-base modifier regulating step (2) resulting solution by the use of sodium pyrophosphate;
(4) Chinese herbal medicine concentrate of addition 1%, 0.5% sodium alginate, 0.03% peppermint into step (3) resulting solution
Oil, regulation temperature is 30~40 DEG C, continues to be uniformly mixed;
(5) step (4) resulting solution is delivered into the next step packing, after detection meets product standard, packed,
Finished product is made.
Chinese herbal medicine concentrate described in above-mentioned preparation method is 15 grams of extracting honeysuckle, 15 grams of chrysanthemum indicum, and 15 grams of corydalis tuber is green
15 grams of tea, 5 grams of asarum, add in 1.5 liters of purified waters, first decocted 20 minutes at 180 DEG C, decocted 40 minutes then at 110 DEG C, filtering
Obtain about 500 milliliters of filtrate.1.5 liters of deionized waters are added in the dregs of a decoction again, 180 DEG C decoct 15 minutes, and 110 DEG C decoct 30 minutes,
It is filtrated to get about 300 milliliters of filtrate.Merge filtrate twice, 110 DEG C are concentrated into 120 milliliters, and the concentrated liquid of tradition Chinese medicine is made, per ml containing life
0.5~1.5mg of medicine.
Gargle prepared by the present invention is brown liquid, lightly seasoned sweet tea.Usually preferably use, use between two meal sooner or later
When, take 15~20ml of gargle in mouth containing gargling 1~2 minute, tasty and refreshing effect can be received by being spued after gargling.Clinical test results
Show:Embodiment product can significantly reduce the bacterial population in oral cavity during Clinical practice, suppress the growth of bacterium, experiment
Forward and backward subject oral cavity bacteria in crevicular fluid culture counts statistical analysis P<0.0001, there is significant difference;Clinical trial 137
Example, allergy and malaise symptoms incidence are 0, and to the overall efficiency 95.20% of Bad Breath Treatment, pretherapy and post-treatment halitosis scoring has
Significant difference;The total effective rate for improving canker sore to treatment is 96.18%, and subject is expired using the totality of embodiment product
Meaning rate reaches 97.88%.Antimicrobial mouthwash prepared by the results show, which can be killed quickly, causes periodontitis, gingivitis, oral cavity
Ulcer, bacterial plaque, dental hemorrhage, the pathogenic bacteria of halitosis, it is safe and non-toxic, non-stimulated, have no side effect, do not develop immunity to drugs, be new
Sterilizing oral, sterilizing clean-keeping articles for use.
A kind of novel polysaccharide antimicrobial mouthwash provided by the present invention and preparation method thereof is described in detail above.
The principle and embodiment of the present invention are set forth herein by embodiment, it is described above to be only intended to help and manage
Solve the method and its core concept of the present invention.It should be pointed out that for those skilled in the art, do not departing from
On the premise of the principle of the invention, some improvement and modification can also be carried out to the present invention, these are improved and modification also falls into this hair
In bright scope of the claims.
Claims (2)
1. a kind of novel polysaccharide antimicrobial mouthwash, it is characterised in that its constituent mass percentage composition is:
Carboxymethyl chitosan:1~3%
Propolis:1~5%
Chinese herbal medicine concentrate:0.5~1%
Sodium alginate:0.2~0.5%
Peppermint oil:0.01~0.05%
Acid-base modifier:0.1~0.5%
Ethanol:5~15%
Surplus is purified water,
Wherein described the concentrated liquid of tradition Chinese medicine is with 10~15 parts by weight honeysuckles, 13~17 parts by weight chrysanthemum indicums, 12~18 parts by weight
Corydalis tuber, 12~18 parts by weight green tea, 3~7 parts by weight asarums are bulk drug, made of water boiling concentration per ml containing crude drug 0.5~
1.5mg the concentrated liquid of tradition Chinese medicine;
The preparation method of the novel polysaccharide antimicrobial mouthwash comprises the following steps:
(1) carboxymethyl chitosan is added directly into dissolution kettle, dissolved with purified water, opened insulating box, be T=40 in temperature
Mechanical agitation at~50 DEG C, until carboxymethyl chitosan all dissolves;
(2) it is added directly into after propolis is dissolved with ethanol in dissolution kettle, ensures that solution is in uniform state;
(3) it is 5.0~6.5 with the pH value of acid-base modifier regulating step (2) resulting solution;
(4) Chinese herbal medicine concentrate, sodium alginate, peppermint oil are added into step (3) resulting solution, regulation temperature is 30~40
DEG C, continue to be uniformly mixed;
(5) step (4) resulting solution is delivered into the next step packing, after detection meets product standard, is packed, be made
Finished product.
2. a kind of novel polysaccharide antimicrobial mouthwash according to claim 1, it is characterised in that described acid-base modifier is
One or both of calgon, sodium pyrophosphate.
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Families Citing this family (7)
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CN105997792A (en) * | 2016-06-21 | 2016-10-12 | 江苏奇力康皮肤药业有限公司 | Traditional Chinese medicine mothproofing and tooth-protecting gargle and preparation method thereof |
CN105919902A (en) * | 2016-06-29 | 2016-09-07 | 江苏开源康达医疗器械有限公司 | Gargle for relieving thirst, wetting throat and resisting bacteria and preparation method thereof |
CN105963237B (en) * | 2016-07-06 | 2019-02-22 | 广东科玮生物技术股份有限公司 | A kind of Novel mouthwash and its preparation method and application |
CN106344428A (en) * | 2016-07-27 | 2017-01-25 | 青岛琛蓝海洋生物工程有限公司 | Marine polysaccharide-based dry mouth symptom relieving mouthwash and preparation method thereof |
CN106176546A (en) * | 2016-08-26 | 2016-12-07 | 湖北立天生物工程有限公司 | Based on the cleaning of the chitosan derivatives degree of depth, bacteriostatic tooth protective collutory and preparation method thereof |
CN110575414A (en) * | 2018-06-08 | 2019-12-17 | 广州医家仁生物科技有限责任公司 | Chinese herbal medicine plant oral cavity maintenance composition and preparation method and use method thereof |
CN113476386A (en) * | 2021-08-19 | 2021-10-08 | 杭州迅腾医疗器械有限公司 | Gargle and preparation method thereof |
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CN1771905A (en) * | 2004-11-10 | 2006-05-17 | 上海立泰哲田生命科技有限公司 | Oral cavity freshener containing herbal material and biological antibacterial peptide |
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