CN108354872A - A kind of Chinese medicinal toothpaste and preparation method thereof - Google Patents
A kind of Chinese medicinal toothpaste and preparation method thereof Download PDFInfo
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- CN108354872A CN108354872A CN201810495998.5A CN201810495998A CN108354872A CN 108354872 A CN108354872 A CN 108354872A CN 201810495998 A CN201810495998 A CN 201810495998A CN 108354872 A CN108354872 A CN 108354872A
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- chinese medicinal
- toothpaste
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- medicinal toothpaste
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/254—Acanthopanax or Eleutherococcus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/02—Local antiseptics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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Abstract
The present invention relates to daily chemical products technical field, more particularly to a kind of Chinese medicinal toothpaste and preparation method thereof.The toothpaste weight percent that Bao Kuo le dish extract and toothpaste matrix , Suo Shu le dish extracts account for the Chinese medicinal toothpaste by percentage to the quality is 0.001%~10%.The present invention is added to le dish as antibacterial anti-inflammatory, pain easing and hemostasis ingredient in toothpaste for the first time, and toothpaste obtained has significant antimicrobial and anti-inflammation efficacy, can effectively improve the oral problems such as swelling and aching of gum, bleeding gums caused by periodontitis, gingivitis etc..
Description
Technical field
The present invention relates to daily chemical products technical field, more particularly to a kind of Chinese medicinal toothpaste and preparation method thereof.
Background technology
The tooth paste product type containing plant component is various at present, is mostly green tea, sponge gourd, aloe extract etc..Toothpaste is made
For articles for daily use, effect is provided to fresh breath, alleviates various oral problems.So toothpaste should have nursing and treatment oral cavity
The effect of problem.The primary efficacy of most of toothpaste is cleaning on the market, can only achieve fresh breath, part bacterium of rinsing the mouth
Effect, and the plant toothpaste that can effectively treat oral problem such as inflammation, bleeding, swelling and aching of gum etc. is fewer and fewer.
Le dish is Araliaceae, also known as Jin roots, Radix Acanthopanacis Trifoliati, Trifoliate Acanthopanax Root, fragrant rattan thorn, three slender acanthopanaxs, goose palm Jin etc. in vain,
Barbed between its form minor matters, thorn also grows hook-shaped thorn three in hook solid, leaf palmately compound leaf alternate, 3 pieces of leaflet in petiole base
Root, it is primary in hillside, cheuch woods side and shrubbery, be distributed mainly on Central China and south, western Sichuan, northwestern Yunnan Province and
Eastern Tibet.《Compendium of Materia Medica》In have Ji Zai le vegetable edibles alcohol sweet in flavor, fragrance is strong, enjoys endless aftertastes.It is clear that research shows that le dish has
Hot toxin expelling, relieves summer heat and quenches one's thirst, and solves tobacco and wine, and weight-reducing is antifatigue and other effects., le dish is mainly used for medicinal tea type drink, health food at present
In, function is also predominantly clearing heat and detoxicating, clears liver and improve vision, relieves fatigue, there is not yet using it for the report in toothpaste.
Invention content
The purpose of the present invention is to provide a kind of Chinese medicinal toothpastes so that the toothpaste has antibacterial and anti-inflammation functions, can be effective
Ground improves the oral problems such as swelling and aching of gum, bleeding gums caused by periodontitis, gingivitis etc..
To achieve the purpose of the present invention, the present invention adopts the following technical scheme that：
Chinese medicinal toothpaste Bao Kuo le dish extracts and toothpaste matrix , Suo Shu le dish extracts provided by the invention account for the Chinese medicine
The weight percent of toothpaste is 0.001%~10%.
, Suo Shu le dish extracts account for the weight hundred of the Chinese medicinal toothpaste in some specific embodiments provided by the invention
Divide than being 2%~10%.
The present invention has oral bacteria the study found that le dish extract is added to Chinese medicinal toothpaste obtained in toothpaste matrix
There is significant inhibition, the oral cavities such as swelling and aching of gum, bleeding gums caused by periodontitis, gingivitis etc. can be effectively improved and asked
Topic.
Preferably, the toothpaste matrix includes moisturizer, rubbing agent, surfactant, thickener, sweetener, anti-corrosion
Agent, fumet, colorant and water.
In some specific embodiments provided by the invention, by weight percentage, the Chinese medicinal toothpaste Bao Kuo le dishes carry
Take object 2~10%, moisturizer 10~35%, rubbing agent 30~50%, surfactant 1~5%, thickener 0.1~1.5%,
Sweetener 0.1~0.5%, preservative 0.1~1%, fumet 1~5%, colorant 0.01~1% and excess water.
As preferred , le dish extract Shi le dish with n-hexane, dichloromethane, methanol, ethyl alcohol, petroleum ether or ethyl acetate
Extract obtained extract.
More preferably , le dish extract Wei le dish alcohol extracts, mono- step You Xuan Wei le dish ethanol extracts of Jin, wherein described
Le dish alcohol extract You le dishes extract to obtain through ethyl alcohol, and the volume fraction of the ethyl alcohol is 50%~100%.
Preferably, the moisturizer is the one or two of sorbierite, glycerine, xylitol, butanediol, polyethylene glycol etc.
More than, more preferably sorbierite and glycerine.
Preferably, the rubbing agent is silica, aluminium hydroxide, dicalcium phosphate dihydrate, precipitated silica, hydrogen-oxygen
Change one or more of aluminium, precipitated calcium carbonate, calcium phosphate dibasic anhydrous, calcium monohydrogen phosphate, calcium carbonate, more preferably titanium dioxide
Silicon.
Preferably, the surfactant is laruyl alcohol sodium sulfovinate, lauryl sodium sulfate, hexadecyl hydrosulfate
The one or more of sodium, sodium stearyl sulfate, aliphatic sulfonic compound etc., more preferably laruyl alcohol sodium sulfovinate.
Preferably, the thickener is organic synthesis glue, inorganic glue or natural plant；The organic synthesis glue is selected from
Sodium carboxymethylcellulose, hydroxyethyl cellulose, carbomer it is one or more, the inorganic glue be selected from silica, colloidality
One or both of aluminium-magnesium silicate, the natural plant is in carrageenin, xanthans, modified guar, carragheen
One or more, more preferably carrageenin.
Preferably, the sweetener be selected from stevioside, Radix Glycyrrhizae, disodium glycyrrhizinate, trisodium glycyrrhetinate, tripotassium glycyrrhetate,
Arrowroot glucin, saccharin, saccharin sodium, sodium cyclohexylsulfamate, L-aspartyl-L-phenylalanine Methylester, acesulfame potassium, three
It is one or more in chlorine sucrose.
Preferably, preservative can be acidic preservative, the acidic preservative is selected from benzoic acid, sorbic acid, propionic acid
And its it is one or more in salt；The preservative can also be ester type preservative, and the ester type preservative is preferably to hydroxyl
Benzoates.
Preferably, the fumet be eugenol, it is Thymol, borneol, citral, vanillic aldehyde, gaultherolin, thin
It is one or more in lotus brain, peppermint sesame oil, spearmint oil, geranium oil, cassia oil, lemon oil, citrus oils, grape-fruit seed oil.
Preferably, the colorant is one or more in mica, titanium dioxide, zinc oxide.
Sweetener of the present invention, preservative, fumet and colorant type be not limited only to mentioned kind, this field
Technical staff thinks feasible type within protection scope of the present invention.
The present invention also provides the preparation methods of the Chinese medicinal toothpaste, include the following steps：
Le vegetable powder is broken into 40~300 mesh, adds 50%~100% ethyl alcohol, -20 DEG C~70 DEG C are extracted get and extracted Dao le dish
Object；
The each component of le dish extract and toothpaste matrix is uniformly mixed, is stood, it is filling, obtain the Chinese medicinal toothpaste.
Preferably, in the preparation method of the Chinese medicinal toothpaste, the volume fraction of ethyl alcohol is 75%~95%.
The present invention is through clinical observation on the therapeutic effect, in the stomatitis patient of 60 swelling and aching of gum, with Chinese medicine tooth of the present invention
After cream 20 days, effective percentage is 98.3%.In the oral cavity patient of 50 bleeding gums, with Chinese medicinal toothpaste of the present invention 20 days
Afterwards, no an example patient bleeding gums.
Chinese medicinal toothpaste provided by the invention , Bao Kuo le dish extracts and toothpaste matrix , Suo Shu le dishes by percentage to the quality
The weight percent that extract accounts for the Chinese medicinal toothpaste is 2~10%.The present invention adds le dish as antibacterial anti-inflammatory ingredient for the first time
It is added in toothpaste, toothpaste obtained has significant antimicrobial and anti-inflammation efficacy, can effectively improve periodontitis, gingivitis etc. and cause
The oral problems such as swelling and aching of gum, bleeding gums.
Specific implementation mode
The invention discloses a kind of Chinese medicinal toothpaste and preparation method thereof, those skilled in the art can use for reference present disclosure,
It is suitably modified technological parameter realization.In particular, it should be pointed out that all similar substitutions and modifications carry out those skilled in the art
Say it is it will be apparent that they are considered as being included in the present invention.The method of the present invention and application have passed through preferred embodiment
It is described, related personnel can obviously not depart from the content of present invention, in spirit and scope to method described herein and answer
With being modified or suitably changing and combine, to realize and apply the technology of the present invention.
To the explanation of the disclosed embodiments, enable those skilled in the art to implement or use the present invention.To this
A variety of modifications of a little embodiments will be apparent to those skilled in the art, as defined herein general
Principle can be realized in other embodiments without departing from the spirit or scope of the present invention.Therefore, the present invention will not
It can be intended to be limited to the embodiments shown herein, and be to fit to consistent with the principles and novel features disclosed in this article
Widest range.
With reference to embodiment, the present invention is further explained：
Embodiment 1
Raw material：
The preparation method of Qi Zhong le dish extracts is as follows：
Le vegetable powder is broken into 40 mesh, adds 75% 20 DEG C of extractions of ethyl alcohol, get Dao le dish extract.
It takes above-mentioned raw materials to be uniformly mixed, stands, it is filling, obtain the Chinese medicinal toothpaste.
Embodiment 2
Raw material：
The preparation method of Qi Zhong le dish extracts is as follows：
Le vegetable powder is broken into 100 mesh, adds 85% ethyl alcohol, 20 DEG C are extracted get Dao le dish extract.
It takes above-mentioned raw materials to be uniformly mixed, stands, it is filling, obtain the Chinese medicinal toothpaste.
Embodiment 3
Raw material：
The preparation method of Qi Zhong le dish extracts is as follows：
Le vegetable powder is broken into 300 mesh, adds 95% ethyl alcohol, 0 DEG C of extraction, get Dao le dish extract.
It takes above-mentioned raw materials to be uniformly mixed, stands, it is filling, obtain the Chinese medicinal toothpaste.
4 clinical effect trial of embodiment
Chinese medicinal toothpaste made from Example 1 to 3 carries out efficacy test.
Material on probation：The roxburgh anoectochilus terminal bud of Chinese medicinal toothpaste and patent CN103735433 that the embodiment of the present invention 1~3 provides carries
Take liquid toothpaste.
Object on probation：Totally 220 people, the stomatitis patient of 120 swelling and aching of gum, the oral cavity patient of 100 bleeding gums, point
For test group and control group, every group include respectively 60 swelling and aching of gum stomatitis patient and 50 bleeding gums oral cavity patient.
Test method and observed content：Subject is normal without disease, blood routine, blood platelet, clotting time and bleeding time.Subject
It is daily to brush teeth 2 times sooner or later, 2 grams of cream is used every time, is brushed teeth 2-5 minutes, 20 days as a treatment course.
The result shows that using the Chinese medicinal toothpaste only one course for the treatment of (20 days) provided by the invention, in the mouth of 60 swelling and aching of gum
In chamber inflammation patient, effective percentage is 98.3%.In the oral cavity patient of 50 bleeding gums, treated with Chinese medicinal toothpaste of the present invention
After 20 days, no longer there is bleeding gums phenomenon.After the toothpaste 20 days of control group, the stomatitis patient's of 60 swelling and aching of gum
Effective percentage is 50%, and 30% still has bleeding gums in the oral cavity patient of 50 bleeding gums.
The above is only a preferred embodiment of the present invention, it is noted that for the ordinary skill people of the art
For member, various improvements and modifications may be made without departing from the principle of the present invention, these improvements and modifications are also answered
It is considered as protection scope of the present invention.
Claims (10)
1. a kind of Chinese medicinal toothpaste , Bao Kuo le dish extracts and toothpaste matrix , Suo Shu le dish extracts account for the weight of the Chinese medicinal toothpaste
It is 0.001%~10% to measure percentage.
2. Chinese medicinal toothpaste according to claim 1, which is characterized in that the toothpaste matrix includes moisturizer, rubbing agent, table
Face activating agent, thickener, sweetener, preservative, fumet, colorant and water.
3. Chinese medicinal toothpaste according to claim 2, which is characterized in that by weight percentage, the Chinese medicinal toothpaste includes
Le dish extract 2~10%, moisturizer 10~35%, rubbing agent 30~50%, surfactant 1~5%, thickener 0.1~
1.5%, sweetener 0.1~0.5%, preservative 0.1~1%, fumet 1~5%, colorant 0.01~1% and excess water.
4. Chinese medicinal toothpaste according to claim 1 or 2, which is characterized in that Suo Shu le dish extract Wei le dish alcohol extracts.
5. Chinese medicinal toothpaste according to claim 3, which is characterized in that Suo Shu le dish alcohol extract You le dishes are extracted through ethyl alcohol
It arrives, the volume fraction of the ethyl alcohol is 50%~100%.
6. according to claim 2~5 any one of them Chinese medicinal toothpaste, which is characterized in that the moisturizer is sorbierite, sweet
The one or more of oil, xylitol, butanediol, polyethylene glycol etc..
7. according to claim 2~6 any one of them Chinese medicinal toothpaste, which is characterized in that the rubbing agent is silica, hydrogen
Aluminium oxide, dicalcium phosphate dihydrate, precipitated silica, aluminium hydroxide, precipitated calcium carbonate, calcium phosphate dibasic anhydrous, calcium monohydrogen phosphate, carbon
One or more of sour calcium.
8. according to claim 2~7 any one of them Chinese medicinal toothpaste, which is characterized in that the surfactant is laruyl alcohol
One kind of sodium sulfovinate, lauryl sodium sulfate, sodium hexadecyl sulfate, sodium stearyl sulfate, aliphatic sulfonic compound etc.
Or it is two or more.
9. according to claim 2~8 any one of them Chinese medicinal toothpaste, which is characterized in that the thickener be organic synthesis glue,
Inorganic glue or natural plant；The organic synthesis glue be selected from sodium carboxymethylcellulose, hydroxyethyl cellulose, carbomer one
Kind is a variety of, and the inorganic glue is selected from one or both of silica, colloidality aluminium-magnesium silicate, and the natural plant is selected from
It is one or more in carrageenin, xanthans, modified guar, carragheen.
10. the preparation method of claim 1~9 any one of them Chinese medicinal toothpaste, which is characterized in that include the following steps：
Le vegetable powder is broken into 40~300 mesh, adds 50%~100% ethyl alcohol, -20 DEG C~70 DEG C are extracted get Dao le dish extract；
The each component of le dish extract and toothpaste matrix is uniformly mixed, is stood, it is filling, obtain the Chinese medicinal toothpaste.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810495998.5A CN108354872A (en) | 2018-05-22 | 2018-05-22 | A kind of Chinese medicinal toothpaste and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810495998.5A CN108354872A (en) | 2018-05-22 | 2018-05-22 | A kind of Chinese medicinal toothpaste and preparation method thereof |
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| CN108354872A true CN108354872A (en) | 2018-08-03 |
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| CN201810495998.5A Pending CN108354872A (en) | 2018-05-22 | 2018-05-22 | A kind of Chinese medicinal toothpaste and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111991289A (en) * | 2020-08-26 | 2020-11-27 | 广东工业大学 | Antibacterial and anti-inflammatory formula and antibacterial and anti-inflammatory toothpaste |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104815230A (en) * | 2015-05-06 | 2015-08-05 | 青岛市口腔医院 | Mouthwash for treating chronic periodontitis |
| CN106581074A (en) * | 2017-03-02 | 2017-04-26 | 唐春枝 | Unguent for treating dental ulcer and preparing method thereof |
-
2018
- 2018-05-22 CN CN201810495998.5A patent/CN108354872A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104815230A (en) * | 2015-05-06 | 2015-08-05 | 青岛市口腔医院 | Mouthwash for treating chronic periodontitis |
| CN106581074A (en) * | 2017-03-02 | 2017-04-26 | 唐春枝 | Unguent for treating dental ulcer and preparing method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 黄晓慧等: ""白簕含氟牙膏的制作"", 《韩山师范学院学报》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111991289A (en) * | 2020-08-26 | 2020-11-27 | 广东工业大学 | Antibacterial and anti-inflammatory formula and antibacterial and anti-inflammatory toothpaste |
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Application publication date: 20180803 |