CN101249056B - Anti-inflammation gargle water and method of preparing the same - Google Patents
Anti-inflammation gargle water and method of preparing the same Download PDFInfo
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- CN101249056B CN101249056B CN2008100257689A CN200810025768A CN101249056B CN 101249056 B CN101249056 B CN 101249056B CN 2008100257689 A CN2008100257689 A CN 2008100257689A CN 200810025768 A CN200810025768 A CN 200810025768A CN 101249056 B CN101249056 B CN 101249056B
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Abstract
The invention provides anti-inflammatory mouth wash which contains anti-inflammatory components that include vitamin B12 and extractive solution of grosvenor momordica fruits. The vitamin B12 can relieve inflammations of the gum and promote the healing of oral ulcers, has high safety, no irritations, no side effects after long-term use, such as drug resistance of microorganisms, tooth discoloration and oral dryness. The extractive solution of grosvenor momordica fruits in the mouth wash has sweet taste instead of bitter taste of the common herbal extractive solution, has long retention time of sweetness in oral cavity, and provides remarkable effects of reliving cough and throat pain. The invention also provides a preparation method of the anti-inflammatory mouth wash.
Description
Technical field
The present invention relates to a kind of oral care implement, particularly a kind of collutory and preparation method thereof with anti-inflammatory effect.
Background technology
Oral disease is by the various microbial common frdquently encountered diseases that cause a disease in the oral cavity, directly influences the healthy of people, and for a long time, people mainly by using various toothpaste and collutory to come cleaning oral cavity, prevent the generation of oral disease.In recent years, in toothpaste, add the various medicated toothpaste that various medicinal herb componentses make and occur in succession, but since its when using in the oral cavity time of staying very short, just be rinsed immediately, so the antibacterial effect that cleans the teeth is not remarkable.
In order to improve the antiphlogistic antibacterial effectiveness of oral care implement, people have developed various anti-inflammation gargle waters, and existing anti-inflammation gargle water mainly is by having added chemical antiinflammatory or extracts of Chinese herbal medicine, having reached the effect of antiinflammatory.
Wherein, the common chemical antiinflammatory has a mouthful calm and peaceful povidone iodine.The safe main component of mouth is hibitane, metronidazole, glycerol etc., and hibitane can be adsorbed on the surface of enamel, oral mucosa and dental plaque, and slowly discharges, and a mouthful Thailand has great broad-spectrum antibacterial, bactericidal action, and can prevent the generation of oral cavity infection; But it has certain requirement to prescription, and soap or Organic substance can weaken its sterilizing ability, and life-time service contains a mouthful safe collutory and easily causes tooth flavescence, the sense of taste to change.Povidone iodine is except that strong bactericidal action, also have the convergence wound surface, reduce and ooze out, promote newborn incarnant characteristics, non-stimulated to mucosa, free from extraneous odour, easy and simple to handle, but it also has certain requirement to prescription, if there is Organic substance, can weaken its sterilization, easily xanthochromia, stick-slip, foaming, nothing precipitate, skin are had certain zest.The chemistry antiinflammatory has following shortcoming: (one) chemical antiinflammatory mainly by the slow release of antimicrobial component, reach the effect of anti-inflammation, but antibacterial effect is not durable, under the insufficient situation of the pharmaceutical quantities that slow release comes out, can cause the drug-fast problem of microorganism; (2) organic antiinflammatory all is a kind of chemical mixture basically, and majority is the effect that reaches antiinflammatory by antibacterial action, and the oral cavity short-term is used can eliminate oral cavity bacterium, but life-time service can make tooth discoloration, and the oral cavity becomes dry; (3) biodegradability of chemical antiinflammatory is poor, and is bigger to the pollution of environment.(4) influence of other material in chemical antiinflammatory is filled a prescription, the effect of antiinflammatory can weaken to some extent.
Extracts of Chinese herbal medicine, the extracting solution as SHUANGHUANLIAN, Radix Ophiopogonis, Radix Salviae Miltiorrhizae etc. are made has character gentleness, little, the safety non-toxic, soluble in water, applied widely of zest.But extracting solution is made up of plurality of Chinese, and color is darker, and Chinese medicine self contains multiple tannin, and the pained and convergence that tannin causes is felt, and makes the mouthfeel variation of collutory, and is bigger to the influence of product mouthfeel.
Therefore, provide a kind of anti-inflammation effect excellence, mouthfeel is good, the property of medicine is permanent and side effect is little anti-inflammation gargle water real for necessary.
Summary of the invention
Based on the deficiencies in the prior art, the object of the present invention is to provide a kind of anti-inflammation effect excellence, mouthfeel is good, the property of medicine is permanent and side effect is little anti-inflammation gargle water, it can play and alleviate various focusing depths represented, alleviates pharyngalgia, promotes the effect of oral ulcer healing.
A kind of anti-inflammation gargle water, it contains the antiinflammatory composition, and described antiinflammatory composition includes vitamin B12 and Fructus Momordicae extracting solution.
In the present invention, anti-inflammation gargle water contains following components in weight percentage:
Wetting agent 8-15%
Edible ethanol 10-20%
Sweeting agent 0.1-0.3%
Caries preventive agent 0.01-0.03%
Food antiseptics 0.1-0.3%
Freshener 0.08-0.2%
Pigment 0.0001-0.0002%
Vitamin B12 0.001-0.1ppm
Fructus Momordicae extracting solution 0.3-0.8%
Deionized water 70-80%.
Wherein, described wetting agent is selected from following one or more materials: sorbitol, glycerol, propylene glycol; Described sweeting agent is selected from following one or more materials: aspartame, Sucralose, acesulfame potassium; Described caries preventive agent is selected from following one or more materials: sodium monofluorophosphate, sodium fluoride, stannous fluoride; Described food antiseptics is selected from following one or more materials: sodium benzoate, methyl hydroxybenzoate, propylparaben; Described freshener comprises edible essence or Mentholum.
Preferred anti-inflammation gargle water of the present invention, contain following components in weight percentage:
Sorbitol 10%
Edible ethanol 10%
Aspartame 0.05%
Acesulfame-K 0.05%
Sodium monofluorophosphate 0.01%
Sodium benzoate 0.1%
Essence 0.05%
Mentholum 0.03%
Pigment 0.0001%
Vitamin B12 0.001ppm
Fructus Momordicae extracting solution 0.8%
Deionized water adds to 100%.
In yet another embodiment of the present invention, anti-inflammation gargle water contains following components in weight percentage:
Sorbitol 13%
Edible ethanol 15%
Aspartame 0.1%
Acesulfame-K 0.1%
Sodium monofluorophosphate 0.02%
Sodium benzoate 0.2%
Essence 0.1%
Mentholum 0.05%
Pigment 0.0001%
Vitamin B12 0.01ppm
Fructus Momordicae extracting solution 0.5%
Deionized water adds to 100%.
In yet another embodiment of the present invention, anti-inflammation gargle water contains following components in weight percentage:
Sorbitol 8%
Edible ethanol 15%
Aspartame 0.1%
Acesulfame-K 0.1%
Sodium monofluorophosphate 0.02%
Sodium benzoate 0.2%
Essence 0.15%
Mentholum 0.03%
Pigment 0.00015%
Vitamin B12 0.1ppm
Fructus Momordicae extracting solution 0.3%
Deionized water adds to 100%.
The present invention also provides a kind of preparation method of anti-inflammation gargle water, described anti-inflammation gargle water includes wetting agent, edible ethanol, sweeting agent, caries preventive agent, food antiseptics, freshener, Mentholum, pigment and antiinflammatory, described antiinflammatory comprises Fructus Momordicae extracting solution and vitamin B12, said method comprising the steps of:
(1) dissolves Water-solubility Material and oil-soluble material respectively: be that wetting agent, part edible ethanol, sweeting agent and caries preventive agent disperse fully with deionized water with Water-solubility Material earlier, in addition fully with oil-soluble material essence, antiseptic and Mentholum dissolving;
(2) under the state that stirs, the oil-soluble material is added in the Water-solubility Material;
When (3) treating biphase mix homogeneously, add vitamin B12, Fructus Momordicae extracting solution and pigment, continue to stir, behind all material mix homogeneously, stop to stir;
(4) will mix uniform material filtering, packing, canned, obtain the anti-inflammation gargle water finished product at last.
Compared with prior art, anti-inflammation gargle water of the present invention contains vitamin B12 and Fructus Momordicae extracting solution, vitamin B12 has keeps epithelial function, promote the regenerated effect of epithelial cell, add in the collutory as functional material, compare with existing chemical antiinflammatory, vitamin B12 is to alleviating various focusing depths represented, promote that the effect of oral ulcer healing is more remarkable, safer, and nonirritant can not produce and cause negative effects such as microorganism Drug resistance, tooth discoloration, oral cavity exsiccation because of life-time service.Another kind of functional material-Fructus Momordicae extracting solution adds in the collutory, has not both had the bitterness sense of general extracts of Chinese herbal medicine, taste and sweet mouthfeel, and the sweet taste holdup time is longer, and has remarkable efficacy at aspects such as treatment cough, laryngopharynx swelling and pain.
The specific embodiment
A kind of anti-inflammation gargle water provided by the invention, it contains the antiinflammatory composition, and described antiinflammatory composition includes vitamin B12 and Fructus Momordicae extracting solution.Anti-inflammation gargle water contains following components in weight percentage:
Wetting agent 8-15%
Edible ethanol 10-20%
Sweeting agent 0.1-0.3%
Caries preventive agent 0.01-0.03%
Food antiseptics 0.1-0.3%
Freshener 0.08-0.2%
Pigment 0.0001-0.0002%
Vitamin B12 0.001-0.1ppm
Fructus Momordicae extracting solution 0.3-0.8%
Deionized water 70-80%.
Wherein, described wetting agent is selected from following one or more materials: sorbitol, glycerol, propylene glycol; Sorbitol and glycerol mouthfeel are little sweet, all are fit to the needs of mouthfeel, and aspect cost performance, sorbitol more has superiority.
Described sweeting agent is selected from following one or more materials: aspartame, Sucralose, acesulfame potassium; The principle moderate according to sweeting agent, in order to measure only taste, add the sweeting agent of phase application quantity, make to such an extent that sample carries out the crowd and gets sensory test, evaluation criterion is to adopt the method for organoleptic examination scoring, and the rating staff is totally 15 people, and scoring is made as 2 fens, at last each sample score is added up, test result is as follows:
| Component | First group | Second group | The 3rd group |
| Aspartame | 0.1 | 0.05 | 0.15 |
| Acesulfame-K | 0.1 | 0.15 | 0.05 |
| Score | 18 | 4 | 8 |
This shows that aspartame and acesulfame-K optimal proportion are 1: 1, the aspartame and the acesulfame-K that promptly add equivalent can obtain best taste, are fit to most consumer.
Described caries preventive agent is selected from following one or more materials: sodium monofluorophosphate, sodium fluoride, stannous fluoride.
Described food antiseptics is selected from following one or more materials: sodium benzoate, methyl hydroxybenzoate, propylparaben; Wherein, sodium benzoate more is applicable to the collutory antiseptic, in the water soluble, prepares fairly simple.
Described freshener comprises edible essence or Mentholum.
The consumption of edible ethanol: the ethanol mouthfeel of high concentration more stimulates, and burst is more arranged, and relatively is fit to westerner's taste, and the Asians then has a preference for comparatively pure and mild mouthfeel, and therefore, the consumption of ethanol is that 10-15% is the most suitable.
Described antiinflammatory is vitamin B12 and Fructus Momordicae extracting solution.Wherein, vitamin B12 is the important coenzyme in the nucleic acid process, synthetic and the fat and proteinic metabolism of choline methionine in it can participate in, and it is synthetic to participate in thymidylic acid indirectly, need be converted into methyl B12 (methyl cobalamin) and actimide (5-deoxyadenosyl cobalamin) in vivo makes it have activity, methyl cobalamin and folic acid metabolism, and folic acid participates in the synthetic of DNA, can cause folic acid deficiency when being deficient in vitamin B12, causes the DNA biosynthesis block, therefore, vitamin B12 is used for collutory, has the epithelial cell of keeping function, and is short through the epithelial cell regeneration, and, vitamin B12 is to the human body nonirritant, and avirulence can carcinogenic and induced gene sudden change, have antiinflammatory, promote the effect of oral ulcer healing.
Fructus Momordicae contains abundant vitamin C, glucosides, fructose, glucose, protein and lipid, the vitamin C that contains 400mg-500mg in every 100G fresh fruit, the sugariness of the glucosides of Fructus Momordicae is 300 times of sucrose sweetness, has hypoglycemic effect, Chinese medicine and pharmacy is thought, Fructus Momordicae is sweet, acid, cool in nature, clearing away heat and cooling blood is arranged, the cough-relieving of promoting the production of body fluid, the laxation toxin expelling, skin care benefit face, effects such as moistening the lung and resolving phlegm, can be used for treating phlegm-heat cough, laryngopharynx swelling and pain, the irritated all diseases of quenching one's thirst, therefore, Fructus Momordicae extracting solution is used for collutory, existing antiinflammatory, the effect that has the auxiliary treatment laryngopharynx swelling and pain again, taste and sweet mouthfeel, safety non-toxic.
The character of Fructus Momordicae extracting solution is a black paste, and sugariness is about 15-20 times of sucrose, slightly aftertaste.Loss on drying 25%-45%, Diluted Alcohol extract 70%-95%.Method for making: dry Fructus Momordicae is got cellulosic sarcocarp and appearance thin skin water or 50% ethanol extracting, concentrate then and form yield about 25%.
The present invention also provides a kind of preparation method of anti-inflammation gargle water, described anti-inflammation gargle water includes wetting agent, edible ethanol, sweeting agent, caries preventive agent, food antiseptics, freshener, Mentholum, pigment and antiinflammatory, described antiinflammatory comprises Fructus Momordicae extracting solution and vitamin B12, said method comprising the steps of:
(1) dissolves Water-solubility Material and oil-soluble material respectively: be that wetting agent, part edible ethanol, sweeting agent and caries preventive agent disperse fully with deionized water with Water-solubility Material earlier, in addition fully with oil-soluble material essence, antiseptic and Mentholum dissolving;
(2) under the state that stirs (50 rev/mins of mixing speeds), the oil-soluble material is added in the Water-solubility Material, stirred 10-20 minute;
When (3) treating biphase mix homogeneously, add vitamin B12, Fructus Momordicae extracting solution and pigment, continue to stir, behind all material mix homogeneously, stop to stir;
(4) will mix uniform material filtering, packing, canned, obtain the anti-inflammation gargle water finished product at last.
Equipment requirements:
Reactor: edible-type stainless steel cauldron (as: rustless steel 314L or 316 types)
Filter: yarn core filter (aperture: 0.1-0.4 μ m)
Environmental requirement:
Adopt 1,000,000 grades air cleaner.
By above-mentioned experimental technique and following each the formulation anti-inflammation gargle water of the present invention provide is provided:
Embodiment 1
In the present embodiment, anti-inflammation gargle water contains following components in weight percentage:
Sorbitol 10%
Edible ethanol 10%
Aspartame 0.05%
Acesulfame-K 0.05%
Sodium monofluorophosphate 0.01%
Sodium benzoate 0.1%
Essence 0.05%
Mentholum 0.03%
Pigment 0.0001%
Vitamin B12 0.001ppm
Fructus Momordicae extracting solution 0.8%
Deionized water adds to 100%.
Embodiment 2
In the present embodiment, anti-inflammation gargle water contains following components in weight percentage:
Sorbitol 13%
Edible ethanol 15%
Aspartame 0.1%
Acesulfame-K 0.1%
Sodium monofluorophosphate 0.02%
Sodium benzoate 0.2%
Essence 0.1%
Mentholum 0.05%
Pigment 0.0001%
Vitamin B12 0.01ppm
Fructus Momordicae extracting solution 0.5%
Deionized water adds to 100%.
Embodiment 3
In the present embodiment, anti-inflammation gargle water contains following components in weight percentage:
Sorbitol 8%
Edible ethanol 15%
Aspartame 0.1%
Acesulfame-K 0.1%
Sodium monofluorophosphate 0.02%
Sodium benzoate 0.2%
Essence 0.15%
Mentholum 0.03%
Pigment 0.00015%
Vitamin B12 0.1ppm
Fructus Momordicae extracting solution 0.3%
Deionized water adds to 100%.
Referring to table 1, below by adopt do not add the collutory (being defined as blank collutory) of vitamin B12 and Fructus Momordicae extracting solution with only add the collutory (being defined as collutory 1) of vitamin B12 and only add the collutory (being defined as collutory 2) of Fructus Momordicae extracting solution and the present invention in the foregoing description one (being defined as collutory 3), the test of comparing of the prescription of the anti-inflammation gargle water of embodiment two (being defined as collutory 4) and embodiment three (being defined as collutory 5) further specifies anti-inflammation gargle water of the present invention in antiinflammatory, promote the oral ulcer healing, alleviate the effect on the pharyngalgia effect:
The collutory that table 1 antiinflammatory consumption does not wait heals, alleviates the comparison of pharyngalgia effect in antiinflammatory, promotion oral ulcer
| Title | Antiinflammatory (B12 and Fructus Momordicae extracting solution) consumption (accounting for the percentage by weight of collutory total amount) | Antiinflammatory, promotion oral ulcer heal, alleviate pharyngalgia effect (week) |
| Blank collutory | Vitamin B12: 0ppm, Fructus Momordicae extracting solution: 0% | Antiinflammatory, promotion oral ulcer heal, alleviate pharyngalgia effective percentage 40% |
| Collutory 1 | Vitamin B12: 0.1ppm, Fructus Momordicae extracting solution: 0% | Antiinflammatory, promotion oral ulcer heal, alleviate pharyngalgia effective percentage 60% |
| Collutory 2 | Vitamin B12: 0ppm, Fructus Momordicae extracting solution: 0.8% | Antiinflammatory, promotion oral ulcer heal, alleviate pharyngalgia effective percentage 55% |
| Collutory 3 | Vitamin B12: 0.001ppm, Fructus Momordicae extracting solution: 0.8% | Antiinflammatory, promotion oral ulcer heal, alleviate pharyngalgia effective percentage 81% |
| Collutory 4 | Vitamin B12: 0.01ppm, Fructus Momordicae extracting solution: 0.5% | Antiinflammatory, promotion oral ulcer heal, alleviate pharyngalgia effective percentage 89% |
| Collutory 5 | Vitamin B12: 0.1ppm, Fructus Momordicae extracting solution: 0.3% | Antiinflammatory, promotion oral ulcer heal, alleviate pharyngalgia effective percentage 80% |
By above-mentioned comparison test, further illustrate the anti-inflammation gargle water that the present invention contains vitamin B12 and Fructus Momordicae extracting solution and promoting the oral ulcer healing, alleviating the remarkable efficacy on the pharyngalgia effective percentage.Because vitamin B12 has and keeps epithelial function, promote the regenerated effect of epithelial cell, add in the collutory as functional material, compare with existing chemical antiinflammatory, vitamin B12 promotes that to alleviating various focusing depths represented the effect of oral ulcer healing is more remarkable, safer, and nonirritant can not produce because of life-time service and cause negative effects such as microorganism Drug resistance, tooth discoloration, oral cavity exsiccation, is the favorable substitutes of chemical antiinflammatory.Another kind of functional material-Fructus Momordicae extracting solution adds in the collutory, the bitterness sense that had not both had general extracts of Chinese herbal medicine, taste and sweet mouthfeel, the sweet taste holdup time is longer, be the succedaneum of the Chinese medicine extraction liquid of other nature and flavor hardships, and have remarkable efficacy at aspects such as treatment cough, laryngopharynx swelling and pain.
Claims (6)
1. anti-inflammation gargle water, it contains the antiinflammatory composition, it is characterized in that: described antiinflammatory composition includes vitamin B12 and Fructus Momordicae extracting solution, and described collutory contains following components in weight percentage:
Wetting agent 8-15%
Edible ethanol 10-20%
Sweeting agent 0.1-0.3%
Caries preventive agent 0.01-0.03%
Food antiseptics 0.1-0.3%
Freshener 0.08-0.2%
Pigment 0.0001-0.0002%
Vitamin B12 0.001-0.1ppm
Fructus Momordicae extracting solution 0.3-0.8%
Deionized water 70-80%;
The preparation method of described Fructus Momordicae extracting solution is: with cellulosic sarcocarp and the appearance thin skin water or the 50% ethanol extracting of dry Fructus Momordicae, and concentrated then forming, yield is 25%.
2. anti-inflammation gargle water as claimed in claim 1 is characterized in that:
Described wetting agent is selected from following one or more materials: sorbitol, glycerol, propylene glycol;
Described sweeting agent is selected from following one or more materials: aspartame, Sucralose, acesulfame potassium;
Described caries preventive agent is selected from following one or more materials: sodium monofluorophosphate, sodium fluoride, stannous fluoride;
Described food antiseptics is selected from following one or more materials: sodium benzoate, methyl hydroxybenzoate, propylparaben;
Described freshener comprises edible essence or Mentholum.
3. anti-inflammation gargle water as claimed in claim 2 is characterized in that: contain following components in weight percentage:
Sorbitol 10%
Edible ethanol 10%
Aspartame 0.05%
Acesulfame-K 0.05%
Sodium monofluorophosphate 0.01%
Sodium benzoate 0.1%
Essence 0.05%
Mentholum 0.03%
Pigment 0.0001%
Vitamin B12 0.001ppm
Fructus Momordicae extracting solution 0.8%
Deionized water adds to 100%.
4. anti-inflammation gargle water as claimed in claim 2 is characterized in that: contain following components in weight percentage:
Sorbitol 13%
Edible ethanol 15%
Aspartame 0.1%
Acesulfame-K 0.1%
Sodium monofluorophosphate 0.02%
Sodium benzoate 0.2%
Essence 0.1%
Mentholum 0.05%
Pigment 0.0001%
Vitamin B12 0.01ppm
Fructus Momordicae extracting solution 0.5%
Deionized water adds to 100%.
5. anti-inflammation gargle water as claimed in claim 2 is characterized in that: contain following components in weight percentage:
Sorbitol 8%
Edible ethanol 15%
Aspartame 0.1%
Acesulfame-K 0.1%
Sodium monofluorophosphate 0.02%
Sodium benzoate 0.2%
Essence 0.15%
Mentholum 0.03%
Pigment 0.00015%
Vitamin B12 0.1ppm
Fructus Momordicae extracting solution 0.3%
Deionized water adds to 100%.
6. the preparation method of an anti-inflammation gargle water, described anti-inflammation gargle water includes wetting agent, edible ethanol, sweeting agent, caries preventive agent, food antiseptics, freshener, Mentholum, pigment and antiinflammatory, described antiinflammatory comprises Fructus Momordicae extracting solution and vitamin B12, it is characterized in that: said method comprising the steps of:
(1) dissolves Water-solubility Material and oil-soluble material respectively: be that wetting agent, part edible ethanol, sweeting agent and caries preventive agent disperse fully with deionized water with Water-solubility Material earlier, in addition fully with oil-soluble material essence, antiseptic and Mentholum dissolving;
(2) under the state that stirs, the oil-soluble material is added in the Water-solubility Material;
When (3) treating biphase mix homogeneously, add vitamin B12, Fructus Momordicae extracting solution and pigment, continue to stir, behind all material mix homogeneously, stop to stir;
(4) will mix uniform material filtering, packing, canned, obtain the anti-inflammation gargle water finished product at last;
Wherein, the preparation method of described Fructus Momordicae extracting solution is: with cellulosic sarcocarp and the appearance thin skin water or the 50% ethanol extracting of dry Fructus Momordicae, and concentrated then forming, yield is 25%.
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| CN103479548B (en) * | 2013-09-11 | 2016-05-11 | 上海方木精细化工有限公司 | Momordica grosvenori GARG |
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