CN106236638B

CN106236638B - Gel toothpaste with anti-inflammatory, antibacterial and teeth strengthening effects and preparation method thereof

Info

Publication number: CN106236638B
Application number: CN201610710165.7A
Authority: CN
Inventors: 孙淑萍; 缪冬冬; 王玲玲; 朱安明; 郭派派; 冯瑞
Original assignee: Wannan Medical College
Current assignee: Guangzhou Kangwang Health Technology Co.,Ltd.
Priority date: 2016-08-24
Filing date: 2016-08-24
Publication date: 2020-06-12
Anticipated expiration: 2036-08-24
Also published as: CN106236638A

Abstract

The invention discloses gel toothpaste with anti-inflammatory, bactericidal and teeth-strengthening effects and a preparation method thereof, wherein the toothpaste comprises the following substances: sodium laureth sulfate SLES, PEG400, sodium carboxymethylcellulose, carbomer 941, sodium polyacrylate, superfine silica gel powder, pearl powder, stevia rebaudiana extractive solution, flos Chrysanthemi Indici extractive solution, herba Menthae extractive solution, Scutellariae radix extractive solution, herba Portulacae extractive solution, herba Erythrinae extractive solution, folium Eucommiae extractive solution, methyl hydroxybenzoate, propylene glycol, distilled water, and essence. Compared with the prior art, the toothpaste has the advantages that the toothpaste is added with various natural plant extracting solutions, so that the reconstruction function of dental pulp can be fully activated, teeth can be fully nourished, and the problems of tooth looseness and dentin fragility are solved; in addition, the toothpaste of the invention has the effects of strengthening teeth, resisting bacteria and inflammation, resisting tooth aging, killing parasites, treating ulcer, clearing away fire, improving eyesight and the like, and can improve the organism immunity of teeth.

Description

Gel toothpaste with anti-inflammatory, antibacterial and teeth strengthening effects and preparation method thereof

Technical Field

The invention relates to toothpaste, in particular to gel toothpaste with anti-inflammatory, bactericidal and tooth-strengthening effects and a preparation method thereof.

Background

With the development of science and technology and the progress of the times, people pay more and more attention to personal health and the interaction between people, tooth looseness and various bacteria located in teeth and oral cavities, which affect the mood and life style of people, such as: the mood is low, the eating is difficult, the people do not feel like opening the mouth to communicate with other people, and the like, which is of course closely related to the toothpaste which is used by people every day. The toothpaste is a daily necessity, is an oral cavity cleaning and nursing product, and has the basic functions of cleaning teeth (oral cavity) and maintaining the health of the oral cavity.

At present, the toothpaste industry is always puzzled by the inevitable side effects of chemical preparations due to the prevailing 'healthy harmony and nature' wind in the global consumption market. In the case of fluorine-containing toothpaste, although fluorine-containing toothpaste can inhibit the formation of dental plaque, if the fluorine-containing concentration is too high, dental plaque is easily formed after use, resulting in incomplete development of enamel on the surface of teeth, partial loss of teeth, and yellowing and roughness of teeth. Meanwhile, as long as the fluorine content in drinking water is 0.7 mg/L, the sodium fluoride is not needed to be used for preventing decayed teeth. Fluorosis, which is manifested by dental fluorosis, heart and kidney damage, muscle fibers and hepatocyte degeneration and joint pain and skeletal deformity, is caused if too much fluorine is taken. In addition, the content of fluorine is high or low in the ecological environment of different regions. Therefore, the fluorine-containing toothpaste is not suitable for people, and particularly, in China, except Shanghai, other provinces, cities and autonomous regions have the problem of high fluorine in parts. The characteristics of nature, environmental protection and small side effect of the Chinese herbal medicine accord with the consumption idea of pursuing nature and health of people. The purchasing motivation of consumers in China is firstly the motivation for practical use and secondly the motivation for seeking the cheap psychology and pursuing famous brand and climbing ratio. Therefore, efficacy, price, and brand are the three main factors affecting consumer purchasing behavior. In the three aspects, the Chinese herbal medicine toothpaste brand has incomparable strong advantages. Firstly, Chinese herbal medicines are used as Chinese medicine competitive products of Chinese nationalities and have a high position in the mind of Chinese people, and people have psychologically created confidence in the efficacy of Chinese herbal medicine toothpaste. The traditional Chinese herbal medicine toothpaste in the market at present is mainly anti-inflammatory and hemostatic toothpaste, which is the type of toothpaste with the best medical effect. In terms of price, the Chinese herbal medicine toothpaste has moderate price, is mainly concentrated in middle and low-end markets and brings substantial feeling to consumers. In terms of brands, most of Chinese herbal medicine toothpaste is a traditional old brand, and has certain popularity and reputation. Therefore, the Chinese herbal medicine toothpaste is a sword for breaking the monopoly of the market of the foreign capital by the brand of domestic toothpaste. Therefore, with the increasing enhancement of environmental protection consciousness of people, the natural and chongshang green color returning becomes a necessary trend, and the toothpaste is a necessary choice for developing and producing the toothpaste.

From the above analysis, the gel toothpaste accords with the concept of harmony and return to nature, and the invention discloses a gel toothpaste with the functions of anti-inflammation, sterilization and tooth strengthening, which comprises the following methods:

(1) the bacteriostatic agent is added into the formula of the toothpaste, so that the toothpaste has a quick bacteriostatic function, and a large amount of bacteria are propagated at night, so that more bacteria exist on the teeth in the morning, and the bacteria can be quickly removed in the morning for brushing teeth, so that the aim of cleaning the oral environment is fulfilled; on the other hand, the toothpaste has lasting antibacterial and bacteriostatic effects, can inhibit the bacterial reproduction for a long time after being used at night,

(2) the cleaning effect of the surfactant is enhanced, and the detergency of the toothpaste is enhanced, so that residual food and toxic substances generated by bacterial metabolism in the oral cavity are effectively removed.

(3) The high-quality essence with moderate cool feeling is added to improve the refreshing capability of the toothpaste. The toothbrushing person experiences clean, cool, refreshing, comfortable and pleasant feelings.

Through the discussion of the solution, the raw materials and the proportion in the aspects of abrasive, essence, surfactant, additive, effective components of traditional Chinese medicine and the like of the toothpaste are studied.

Disclosure of Invention

The invention aims at providing a novel gel toothpaste containing natural component extracts and having the effects of resisting inflammation, sterilizing and strengthening teeth.

The 2 nd object of the present invention is a method for preparing the above toothpaste.

In order to achieve the aim, the invention provides gel toothpaste with anti-inflammatory, antibacterial and tooth strengthening effects, which comprises the following substances:

the essence is selected from one or more of lemon essence, osmanthus essence and pineapple essence.

A method for preparing gel toothpaste with anti-inflammatory, antibacterial and teeth consolidating effects comprises the following steps:

a) weighing 0.5-1.5g of sodium carboxymethylcellulose, adding into a beaker containing 10-30ml of distilled water, standing at room temperature for 1-3 days, and allowing the sodium carboxymethylcellulose to fully expand for later use;

b) weighing 0.1-0.2g of sodium polyacrylate, adding into a beaker containing 0.1-0.15g of glycerol, stirring, adding 5-10ml of distilled water, standing for 1-2 days, and allowing the mixture to fully swell for later use;

c) weighing 9410.15-0.6g of carbomer, adding into a beaker containing 2.5-10ml of distilled water, standing at room temperature for 1-3 days, and allowing it to fully swell for later use;

d) weighing 0.01-0.05g of methylparaben, adding into a beaker containing 1-5ml of propylene glycol, heating at 80 ℃ until the methylparaben is fully dissolved to obtain a preservative solution for later use;

e) respectively taking 0.5-2g of centrifuged eucommia ulmoides leaf extract, 0.5-2g of stevia rebaudiana extract, 0.5-2g of wild chrysanthemum extract, 0.5-2g of mint extract, 0.5-1.5g of scutellaria baicalensis extract, 0.5-2g of purslane extract, 0.5-2g of olea europaea extract and 0.5-2g of eclipta alba extract, and uniformly mixing to obtain an extract mixed solution for later use;

f) mixing all the swelling materials obtained in the steps a), b) and c), stirring for 5-10 minutes along the same direction until no small bubbles exist in the gel, then adding the extracting solution mixed liquor and the preservative solution, and stirring for 10-15 minutes until the color in the beaker is uniformly distributed;

g) then adding 0.5-1.5g of essence, 1-5g of PEG4001-5g, 0.2-2g of micropowder silica gel and 0.01-0.1g of white pearl powder in sequence, stirring for 10-15 minutes by a stirrer with 400rpm, standing for 8-12 hours in a refrigerator with the temperature of 4 ℃ after completely mixing, taking out, adding 0.5-2g of sodium laureth sulfate SLES, and stirring for 5-10 minutes to obtain the gel toothpaste with the functions of resisting inflammation, sterilizing and strengthening teeth.

The components in the invention are as follows:

purslane is also called longevity herb in China, and the record of the compendium of materia medica records that the purslane can disperse blood and reduce swelling, promote intestines and smooth fetus, detoxify and treat stranguria and treat postpartum sweating due to debility. Purslane is rich in a large amount of flavonoids, adrenalines, polysaccharides, various vitamins, amino acids and other compounds. The extract has good effect in scavenging free radicals, and has pharmacological, nutritional and health promoting effects. Since herba Portulacae has inhibitory effect on dysentery bacillus, typhoid bacillus, Escherichia coli and Staphylococcus aureus, the extract has antiinflammatory and antiinflammatory effects.

Stevia rebaudiana, also known as stevia rebaudiana and sugar grass, is one of the sugar plants with higher sweetness at present. The stevia sugar contained in the leaves has the characteristics of low heat, high sweetness, good taste quality, high temperature resistance, good stability and the like, is safe and nontoxic to human bodies, has the effects of reducing blood pressure, promoting metabolism, treating hyperacidity and the like, and also has certain auxiliary curative effects on patients with obesity, diabetes, cardiovascular diseases, hypertension, arteriosclerosis, decayed teeth and the like. Because it has the properties of heat resistance, stability, corrosion resistance and the like, the modified toothpaste is not easy to denature and deteriorate when being added into food or toothpaste daily chemicals, has low requirement on the pH value, has long storage period, and cannot agglomerate, brown stain and the like. Therefore, the stevia extract is used in the toothpaste, which not only can solve the sweet taste of the product, but also can reduce the proliferation rate of bacteria in the oral cavity and reduce the occurrence of dental caries, and conforms to the notice spirit of reducing the using amount of saccharin in the state department.

Wild chrysanthemum is bitter in taste and slightly cold in nature, enters lung and liver meridians, and has the effects of clearing away heat and toxic materials, dispelling wind and calming the liver. The medicinal part of the wild chrysanthemum is mainly a capitate inflorescence, and the main effective components of the wild chrysanthemum are volatile oil, flavone and lactone. The wild chrysanthemum extract is added into the toothpaste as an additive, not only has the functions of clearing away heat and toxic materials, but also has obvious bacteriostatic and anti-inflammatory effects; in addition, the traditional Chinese medicine composition also has a certain curative effect on patients with periodontitis and gingivitis, can improve the health problems of oral cavities and teeth after long-term use, and benefits consumers.

Herba Ecliptae has hemostatic, kidney invigorating, repercussive, blood cooling, and hemostatic effects. The eclipta alba contains various chemical components such as coumaric grass ethers, triterpenoid saponins, flavonoids and the like, and has the functions of preventing caries and strengthening teeth and the functions of cooling blood and stopping bleeding, diminishing inflammation, annealing and diminishing swelling when being used as an additive of the toothpaste.

The fructus Canarii albi contains terpenoids, phenols, polysaccharides, etc., and has effects of nourishing yin, moistening lung, clearing heat, promoting diuresis, eliminating phlegm, relieving cough, dispelling pathogenic wind, relieving pain, clearing pathogenic fire, removing toxic substances, clearing heat, and cooling blood. The flavone is a polyphenol substance existing in plants, and has antibacterial, antioxidant and antiviral properties. The fructus Canarii albi extract can be used in toothpaste to improve anti-inflammatory and antibacterial effects of toothpaste, and improve tooth environment and make people comfortable after long-term use.

Scutellariae radix can be used for treating epidemic febrile disease, upper respiratory infection, cough due to lung heat, jaundice due to damp-heat, pneumonia, and dysentery. The infection of the oral cavity by bacteria and viruses is also a part of factors causing the diseases, so that the problem of the infection of the oral cavity by the bacteria and the viruses is more necessary to solve. The Scutellariae radix extract has antioxidant, free radical scavenging, antiinflammatory, antiviral, and antiallergic effects, and can protect immune system, cardiovascular system, cerebrovascular system, digestive system, and nervous system. The extract of the toothpaste is added into the toothpaste, so that the toothpaste has the functions of diminishing inflammation and stopping bleeding, has certain auxiliary effect on relieving inflammation of gingiva, and solves the problems of inflammation of oral teeth, virus infection and the like.

The folium Eucommiae decoction has antibacterial and anti-inflammatory effects, and especially has inhibitory effect on Bacillus tuberculosis, Shigella flexneri, Escherichia coli, Bacillus pyocyaneus, Staphylococcus aureus, pneumococcus, Bacillus anthracis, etc. The folium Eucommiae has effects of improving immunity of human immune system, preventing diseases, inhibiting pathogen invasion, and resisting immunodeficiency and virus. In addition, the eucommia ulmoides leaves also have the effects of preventing and treating tooth loosening, preventing periodontal diseases and the like.

The mint has the effects of perfuming, entering lung and liver channels, dispersing wind heat, clearing throat, promoting eruption, removing toxin, soothing liver, relieving depression, relieving itching and the like, so the mint is used for perfuming toothpaste, food, cold beverage, cosmetics and perfumed soap. The essence component of the mint extract is added into the toothpaste, so that bacteria and tartar causing dental caries can be effectively removed, and the effects of relieving toothache and nourishing gingiva can be achieved; can whiten teeth, keep the firmness of the teeth, can remove the dirt of the teeth from inside to outside, has strong cleaning effect on the oral cavity, especially can solve the problem of dead angles of the oral cavity, and can not stimulate the oral cavity after long-term use.

The micro silica gel powder particles are smooth and uniform, the hardness is moderate, the friction effect between the toothpaste and teeth can be increased in the daily toothpaste articles, and the toothpaste adopting the micro silica gel powder friction agent can not damage the tooth surfaces and periodontal tissues, so that the tooth cleaning effect is achieved.

Sodium laureth sulfate SLES is used as foaming agent in toothpaste, and has the advantages of abundant and stable foam, strong detergency, low alkalinity, small irritation to oral mucosa, and good stability to temperature. The surfactant can reduce surface tension, make toothpaste rapidly diffuse in oral cavity, penetrate and loosen dirt and food residue on tooth surface, make it emulsified by abundant foam and suspended, and rinse and remove when gargling, thereby achieving the purpose of cleaning teeth and oral cavity.

The invention has the beneficial effects that: a large amount of natural plant extract ingredients are added in the formula of the toothpaste, so that on one hand, the breeding of bacteria and fungi is reduced by cleaning teeth and fixing the teeth; on the other hand, the purpose of inhibiting the growth of bacteria and fungi is achieved through anti-inflammatory sterilization. Meanwhile, the reconstruction function of dental pulp can be fully activated, so that teeth can obtain sufficient nutrition and the chronic diseases of tooth looseness and tooth weakness are solved; in addition, the toothpaste of the invention has the effects of strengthening teeth, resisting bacteria and inflammation, resisting tooth aging, killing parasites, treating ulcer, clearing away fire, improving eyesight and the like, and can improve the organism immunity of teeth.

Detailed Description

The following describes in detail specific embodiments of the present invention. It should be understood that the detailed description and specific examples, while indicating the present invention, are given by way of illustration and explanation only, not limitation. In the examples, methylparaben, SLES, PEG400, sodium polyacrylate, aerosil, carbomer, sodium carboxymethylcellulose, propylene glycol and pearl essence are all commercially available from kyo benomyl permanent codex ltd.

Example 1

A gel toothpaste with anti-inflammatory, antibacterial and teeth consolidating effects comprises the following substances: 1.0g of sodium laureth sulfate SLES, 1.5g of polyethylene glycol 400PEG400, 1.3g of sodium carboxymethylcellulose, 9410.15 g of carbomer, 0.2g of sodium polyacrylate, 1.5g of silica gel micropowder, 0.06g of pearl powder, 1.0g of stevia rebaudiana extractive solution, 1.0g of wild chrysanthemum flower extractive solution, 1.0g of mint extractive solution, 0.5g of scutellaria baicalensis extractive solution, 1.0g of purslane extractive solution, 1.0g of olea europaea extractive solution, 1.3g of eclipta alba extractive solution, 1.2g of eucommia ulmoides leaf extractive solution, 0.01g of methylparaben, 0.15g of glycerol, 1ml of propylene glycol, 32.5ml of distilled water and 0.9g of lemon essence.

1.1 preparation of eucommia ulmoides leaf extract:

weighing 20g of folium cortex eucommiae, putting the folium cortex eucommiae into a round-bottom flask, adding 30 times of water, soaking for 0.5h, putting the folium cortex eucommiae into an electric heating jacket, extracting for 1.5h by using a continuous reflux extractor, adding 20 times of water for 2 times, extracting for 1.0h, adding 15 times of water for 3 times, extracting for 0.5h, filtering each time, combining filtrates, finally concentrating the volume of the filtrate to 4 times of the weight of the folium cortex eucommiae, centrifuging for 15 minutes under a 2500r/min centrifuge, and taking supernatant for later use.

1.2 preparing the olive extract:

weighing 25g of olea europaea, soaking for 0.5h, heating, decocting and extracting for 3 times, adding 30 times of water for the 1 st time, extracting for 2h, adding 20 times of water for the 2 nd time, extracting for 1.0h, adding 12 times of water for the 3 rd time, extracting for 0.5h, filtering each time, combining the filtrates, finally concentrating the volume of the filtrate to be 3 times of the weight of the olea europaea, centrifuging for 15 minutes under a 2500r/min centrifugal machine, and taking the supernatant for later use.

1.3 preparation of purslane extract:

weighing 20g of purslane, soaking for 0.5h, heating, decocting and extracting for 3 times, adding 20 times of water for the 1 st time, extracting for 1.5h, adding 15 times of water for the 2 nd time, extracting for 1.0h, adding 10 times of water for the 3 rd time, extracting for 0.5h, filtering each time, combining the filtrates, finally concentrating the volume of the filtrate to be 4 times of the weight of the purslane, centrifuging for 15 minutes under a 2500r/min centrifugal machine, and taking the supernatant for later use.

1.4 preparation of peppermint extract:

weighing 50g of mint, putting the mint into a round-bottom flask, adding 20 times of water, soaking for 0.5h, putting the mint into an electric heating jacket, extracting for 2.5h by using a continuous reflux extractor, adding 15 times of water for 2 times, extracting for 1.5h, adding 10 times of water for 3 times, extracting for 1h, filtering for each time, combining filtrates, finally concentrating the volume of the filtrate to be 3 times of the weight of the mint, centrifuging for 15 minutes under a 2500r/min centrifuge, and taking supernatant for later use.

1.5 preparing eclipta alba extract:

weighing 40g of eclipta alba, soaking for 0.5h, heating, decocting and extracting for 3 times, adding 20 times of water for 1 time, extracting for 1.5h, adding 15 times of water for 2 times, extracting for 1.0h, adding 10 times of water for 3 times, extracting for 0.5h, filtering each time, combining filtrates, finally concentrating the volume of the filtrate to be 3 times of the weight of the eclipta alba, centrifuging for 15 minutes under a centrifuge of 2500r/min, and taking supernatant for later use.

1.6 preparation of stevia rebaudiana extractive solution:

weighing 30g of stevia rebaudiana, soaking for 0.5h, heating, decocting and extracting for 3 times, adding 20 times of water for 1 time, extracting for 1.5h, adding 13 times of water for 2 times, extracting for 1.0h, adding 9 times of water for 3 times, extracting for 0.5h, filtering each time, combining filtrates, finally concentrating the volume of the filtrate to be 3 times of the weight of the stevia rebaudiana, centrifuging for 15 minutes under a centrifuge of 2500r/min, and taking supernatant for later use.

1.7 preparation of wild chrysanthemum flower extract:

weighing 20g of wild chrysanthemum, putting the wild chrysanthemum into a round-bottom flask, adding 17 times of 70% ethanol solution, soaking for 0.5h, putting the flask into an electric heating jacket, extracting for 1.5h by using a continuous reflux extractor, adding 13 times of 70% ethanol solution for 2 times, extracting for 1.0h, adding 8 times of 70% ethanol solution for 3 times, extracting for 0.5h, filtering each time, combining filtrates, finally concentrating the volume of the filtrate to 3 times of the weight of the wild chrysanthemum, centrifuging for 15 minutes under a 2500r/min centrifuge, and taking supernatant for later use.

1.8 preparation of the scutellaria baicalensis extracting solution:

weighing 30g of scutellaria baicalensis coarse powder, soaking for 0.5h, heating, decocting and extracting for 3 times, adding 20 times of water for 1 time, extracting for 1.5h, adding 15 times of water for 2 times, extracting for 1.0h, adding 10 times of water for 3 times, extracting for 0.5h, filtering each time, combining filtrates, finally concentrating the volume of the filtrate to be 4 times of the weight of the scutellaria baicalensis, centrifuging for 15 minutes under a 2500r/min centrifugal machine, and taking supernatant for later use.

1.9 the preparation method of the gel toothpaste with the anti-inflammatory, bactericidal and teeth-strengthening effects comprises the following steps:

a) weighing 1.3g of sodium carboxymethylcellulose, adding into a beaker filled with 20ml of distilled water, standing at room temperature for 2 days, and fully expanding for later use;

b) weighing 0.2g of sodium polyacrylate, adding the sodium polyacrylate into a beaker containing 0.15g of glycerin, stirring and uniformly mixing, adding 10ml of distilled water, standing for 1 day, and fully swelling for later use;

c) weighing 9410.15 g of carbomer, adding into a beaker containing 2.5ml of distilled water, standing at room temperature for 2 days, and allowing the carbomer to fully swell for later use;

d) weighing 0.01g of methyl paraben, adding into a beaker containing 1ml of propylene glycol, and heating at 80 ℃ until the methyl paraben is fully dissolved to obtain a preservative solution for later use;

e) respectively taking 1.2g of centrifuged eucommia leaf extract, 1.0g of stevia extract, 1.0g of wild chrysanthemum extract, 1.0g of mint extract, 0.5g of scutellaria extract, 1.0g of purslane extract, 1.0g of olea europaea extract and 1.3g of eclipta alba extract, and uniformly mixing to obtain extract mixed liquor for later use;

f) mixing all the swelling materials obtained in the steps a), b) and c), stirring for 10 minutes along the same direction until no small bubbles exist in the gel, adding the extracting solution mixed liquor and the preservative solution, and stirring for 15 minutes until the color in the beaker is uniformly distributed;

g) and then sequentially adding 0.9g of lemon essence, 1.5g of PEG4001.5g, 1.5g of micro-powder silica gel and 0.06g of white pearl powder, stirring for 15 minutes by a stirrer at 400rpm, standing for 10 hours in a refrigerator at 4 ℃ after completely mixing, taking out, adding 1.0g of sodium lauryl polyether sulfate (SLES), and stirring for 10 minutes to obtain the gel toothpaste with the functions of resisting inflammation, sterilizing and strengthening teeth.

Example 2

A gel toothpaste with anti-inflammatory, antibacterial and teeth consolidating effects comprises the following substances: 1.2g of sodium laureth sulfate SLES, 1.4g of polyethylene glycol 400PEG 4002 g, 1.4g of sodium carboxymethylcellulose, 9410.15 g of carbomer, 0.2g of sodium polyacrylate, 1.5g of aerosil, 0.04g of pearl powder, 0.8g of stevia rebaudiana extractive solution, 0.8g of wild chrysanthemum flower extractive solution, 1.2g of mint extractive solution, 0.6g of scutellaria baicalensis extractive solution, 0.9g of purslane extractive solution, 1.0g of lycopodium chinense extractive solution, 1.0g of eclipta alba extractive solution, 1.0g of eucommia ulmoides leaf extractive solution, 0.01g of methylparaben, 0.1g of glycerol, 1ml of propylene glycol, 32.5ml of distilled water and 1.1g of osmanthus fragrans essence.

2.1 preparation of eucommia ulmoides leaf extract:

weighing 40g of eucommia leaves, putting the eucommia leaves into a round-bottom flask, adding 30 times of water, soaking for 0.5h, then putting the eucommia leaves into an electric heating jacket, extracting for 2h by using a continuous reflux extractor, adding 20 times of water for 2 times, extracting for 1.0h, adding 15 times of water for 3 times, extracting for 0.5h, filtering each time, combining filtrates, finally concentrating the volume of the filtrate to be 3 times of the weight of the eucommia leaves, centrifuging for 15 minutes under a 2500r/min centrifuge, and taking supernatant for later use.

2.2 preparing the olive extract:

weighing 30g of olea europaea, soaking for 0.5h, heating, decocting and extracting for 3 times, adding 20 times of water for the 1 st time, extracting for 2h, adding 15 times of water for the 2 nd time, extracting for 1.0h, adding 10 times of water for the 3 rd time, extracting for 0.5h, filtering each time, combining the filtrates, finally concentrating the volume of the filtrate to be 3 times of the weight of the olea europaea, centrifuging for 15 minutes under a 2500r/min centrifugal machine, and taking the supernatant for later use.

2.3 preparation of purslane extract:

weighing 25g of purslane, soaking for 0.5h, heating, decocting and extracting for 3 times, adding 25 times of water for the 1 st time, extracting for 1.5h, adding 15 times of water for the 2 nd time, extracting for 1.0h, adding 10 times of water for the 3 rd time, extracting for 0.5h, filtering each time, combining the filtrates, finally concentrating the volume of the filtrate to be 4 times of the weight of the purslane, centrifuging for 15 minutes under a 2500r/min centrifugal machine, and taking the supernatant for later use.

2.4 preparation of peppermint extract:

weighing 50g of mint, putting the mint into a round-bottom flask, adding 20 times of water, soaking for 0.5h, putting the mint into an electric heating jacket, extracting for 2.5h by using a continuous reflux extractor, adding 13 times of water for the 2 nd time, extracting for 1.5h, adding 10 times of water for the 3 rd time, extracting for 1h, filtering for each time, combining filtrates, finally concentrating the volume of the filtrate to be 2 times of the weight of the mint, centrifuging for 15 minutes under a 2500r/min centrifuge, and taking supernatant for later use.

2.5 preparing the eclipta alba extracting solution:

weighing 20g of eclipta alba, soaking for 0.5h, heating, decocting and extracting for 3 times, adding 20 times of water for 1 time, extracting for 1.5h, adding 15 times of water for 2 times, extracting for 1.0h, adding 10 times of water for 3 times, extracting for 0.5h, filtering each time, combining filtrates, finally concentrating the volume of the filtrate to be 4 times of the weight of the eclipta alba, centrifuging for 15 minutes under a centrifuge of 2500r/min, and taking supernatant for later use.

2.6 preparation of stevia rebaudiana extractive solution:

weighing 30g of stevia rebaudiana, soaking for 0.5h, heating, decocting and extracting for 3 times, adding 25 times of water for the 1 st time, extracting for 1.5h, adding 15 times of water for the 2 nd time, extracting for 1.0h, adding 10 times of water for the 3 rd time, extracting for 0.5h, filtering each time, combining filtrates, finally concentrating the volume of the filtrate to be 3 times of the weight of the stevia rebaudiana, centrifuging for 15 minutes under a 2500r/min centrifugal machine, and taking supernatant for later use.

2.7 preparation of wild chrysanthemum flower extract:

2.8 preparation of the scutellaria baicalensis extracting solution:

weighing 40g of scutellaria baicalensis coarse powder, soaking for 0.5h, heating, decocting and extracting for 3 times, adding 25 times of water for 1 time, extracting for 1.5h, adding 15 times of water for 2 times, extracting for 1.0h, adding 10 times of water for 3 times, extracting for 0.5h, filtering each time, combining filtrates, finally concentrating the volume of the filtrate to be 3 times of the weight of the scutellaria baicalensis, centrifuging for 15 minutes under a 2500r/min centrifugal machine, and taking supernatant for later use.

2.9 the preparation method of the gel toothpaste with the anti-inflammatory, bactericidal and teeth-strengthening effects comprises the following steps:

a) weighing 1.4g of sodium carboxymethylcellulose, adding into a beaker filled with 20ml of distilled water, standing at room temperature for 1 day, and fully expanding for later use;

b) weighing 0.2g of sodium polyacrylate, adding the sodium polyacrylate into a beaker containing 0.1g of glycerol, stirring and uniformly mixing, adding 10ml of distilled water, standing for 1 day, and fully swelling for later use;

c) weighing 0.15g of carbomer, adding into a beaker containing 2.5ml of distilled water, standing at room temperature for 2 days, and allowing the carbomer to fully swell for later use;

e) respectively taking 1.0g of centrifuged eucommia ulmoides leaf extract, 0.8g of stevia rebaudiana extract, 0.8g of wild chrysanthemum extract, 1.2g of mint extract, 0.6g of scutellaria baicalensis extract, 0.9g of purslane extract, 1.0g of olea europaea extract and 1.0g of eclipta alba extract, and uniformly mixing to obtain extract mixed liquor for later use;

f) mixing all the swelling materials obtained in the steps a), b) and c), stirring for 10 minutes along the same direction until no small bubbles exist in the gel, adding the extracting solution mixed liquor and the preservative solution, and stirring for 13 minutes until the color in the beaker is uniformly distributed;

g) and sequentially adding 1.1g of osmanthus essence, PEG 4002 g, 1.5g of micro-powder silica gel and 0.04g of white pearl powder, stirring for 12 minutes by a stirrer at 400rpm, standing for 12 hours in a refrigerator at 4 ℃ after completely mixing, taking out, adding 1.2g of sodium laureth sulfate SLES, and stirring for 10 minutes to obtain the gel toothpaste with the effects of resisting inflammation, sterilizing and strengthening teeth.

Example 3

A gel toothpaste with anti-inflammatory, antibacterial and teeth consolidating effects comprises the following substances: 1.5g of sodium laureth sulfate SLES, 1.3g of polyethylene glycol 400PEG400, 1.2g of sodium carboxymethylcellulose, 9410.15 g of carbomer, 0.1g of sodium polyacrylate, 0.8g of silica gel micropowder, 0.03g of pearl powder, 0.7g of stevia rebaudiana extractive solution, 1.2g of wild chrysanthemum flower extractive solution, 0.7g of mint extractive solution, 0.6g of scutellaria baicalensis extractive solution, 0.7g of purslane extractive solution, 0.7g of olea europaea extractive solution, 1.0g of eclipta alba extractive solution, 0.5g of eucommia ulmoides leaf extractive solution, 0.01g of methylparaben, 0.1g of glycerol, 1ml of propylene glycol, 27.5ml of distilled water and 1.4g of pineapple essence.

3.1 preparation of eucommia ulmoides leaf extract:

weighing 30g of eucommia leaves, putting the eucommia leaves into a round-bottom flask, adding 28 times of water, soaking for 0.5h, then putting the eucommia leaves into an electric heating jacket, extracting for 1.5h by using a continuous reflux extractor, adding 20 times of water for the 2 nd time, extracting for 1.0h, adding 15 times of water for the 3 rd time, extracting for 0.5h, filtering each time, combining filtrates, finally concentrating the volume of the filtrate to be 3 times of the weight of the eucommia leaves, centrifuging for 15 minutes under a 2500r/min centrifuge, and taking supernatant for later use.

3.2 preparing the olive extract:

weighing 30g of olea europaea, soaking for 0.5h, heating, decocting and extracting for 3 times, adding 25 times of water for the 1 st time, extracting for 2h, adding 18 times of water for the 2 nd time, extracting for 1.0h, adding 10 times of water for the 3 rd time, extracting for 0.5h, filtering each time, combining the filtrates, finally concentrating the volume of the filtrate to be 3 times of the weight of the olea europaea, centrifuging for 15 minutes under a 2500r/min centrifugal machine, and taking the supernatant for later use.

3.3 preparation of purslane extract:

weighing 30g of purslane, soaking for 0.5h, heating, decocting and extracting for 3 times, adding 25 times of water for the 1 st time, extracting for 1.5h, adding 15 times of water for the 2 nd time, extracting for 1.0h, adding 10 times of water for the 3 rd time, extracting for 0.5h, filtering each time, combining the filtrates, finally concentrating the volume of the filtrate to be 4 times of the weight of the purslane, centrifuging for 15 minutes under a 2500r/min centrifugal machine, and taking the supernatant for later use.

3.4 preparation of peppermint extract:

weighing 30g of mint, putting the mint into a round-bottom flask, adding 25 times of water, soaking for 0.5h, putting the mint into an electric heating jacket, carrying out reflux extraction for 3 times by using a continuous reflux extractor, carrying out 2.5h extraction for the 1 st time, adding 18 times of water for the 2 nd time, extracting for 1.5h, adding 12 times of water for the 3 rd time, extracting for 1h, filtering each time, combining filtrates, finally concentrating the volume of the filtrate to be 3 times of the weight of the mint, centrifuging for 15 minutes by using a 2500r/min centrifuge, and taking supernatant for later use.

3.5 preparation of eclipta alba extract:

weighing 30g of eclipta alba, soaking for 0.5h, heating, decocting and extracting for 3 times, adding 25 times of water for 1 time, extracting for 1.5h, adding 18 times of water for 2 times, extracting for 1.0h, adding 12 times of water for 3 times, extracting for 0.5h, filtering each time, combining filtrates, finally concentrating the volume of the filtrate to be 3 times of the weight of the eclipta alba, centrifuging for 15 minutes under a centrifuge of 2500r/min, and taking supernatant for later use.

3.6 preparation of stevia extract:

weighing 30g of stevia rebaudiana, soaking for 0.5h, heating, decocting and extracting for 3 times, adding 25 times of water for the 1 st time, extracting for 1.5h, adding 15 times of water for the 2 nd time, extracting for 1.0h, adding 10 times of water for the 3 rd time, extracting for 0.5h, filtering each time, combining filtrates, finally concentrating the volume of the filtrate to 4 times of the weight of the stevia rebaudiana, centrifuging for 15 minutes under a 2500r/min centrifugal machine, and taking supernatant for later use.

3.7 preparation of wild chrysanthemum flower extract:

weighing 20g of wild chrysanthemum, putting the wild chrysanthemum into a round-bottom flask, adding 16 times of 70% ethanol solution, soaking for 0.5h, putting the flask into an electric heating jacket, extracting for 1.5h by using a continuous reflux extractor, adding 12 times of 70% ethanol solution for 2 times, extracting for 1.0h, adding 9 times of 70% ethanol solution for 3 times, extracting for 0.5h, filtering each time, combining filtrates, finally concentrating the volume of the filtrate to 3 times of the weight of the wild chrysanthemum, centrifuging for 15 minutes under a 2500r/min centrifuge, and taking supernatant for later use.

3.8 preparation of the scutellaria baicalensis extracting solution:

weighing 40g of scutellaria baicalensis coarse powder, soaking for 0.5h, heating, decocting and extracting for 3 times, adding 30 times of water for 1 time, extracting for 1.5h, adding 20 times of water for 2 times, extracting for 1.0h, adding 10 times of water for 3 times, extracting for 0.5h, filtering each time, combining filtrates, finally concentrating the volume of the filtrate to be 4 times of the weight of the scutellaria baicalensis, centrifuging for 15 minutes under a centrifuge of 2500r/min, and taking supernatant for later use.

3.9 the preparation method of the gel toothpaste with the anti-inflammatory, bactericidal and teeth-strengthening effects comprises the following steps:

a) weighing 1.2g of sodium carboxymethylcellulose, adding into a beaker filled with 20ml of distilled water, standing at room temperature for 1 day, and fully expanding for later use;

b) weighing 0.1g of sodium polyacrylate, adding the sodium polyacrylate into a beaker containing 0.1g of glycerol, stirring and uniformly mixing, adding 5ml of distilled water, standing for 1 day, and fully swelling for later use;

e) respectively taking 0.5g of centrifuged eucommia leaf extract, 0.7g of stevia extract, 1.2g of wild chrysanthemum extract, 0.7g of mint extract, 0.6g of scutellaria extract, 0.7g of purslane extract, 0.7g of olea europaea extract and 1.0g of eclipta alba extract, and uniformly mixing to obtain extract mixed liquor for later use;

g) then sequentially adding 1.4g of pineapple essence, 1.3g of PEG4001.3 g, 0.8g of micro-powder silica gel and 0.03g of white pearl powder, stirring for 12 minutes by a stirrer at 400rpm, standing for 12 hours in a refrigerator at 4 ℃ after completely mixing, taking out, adding 1.5g of sodium lauryl polyether sulfate (SLES), and stirring for 10 minutes to obtain the gel toothpaste with the functions of resisting inflammation, sterilizing and strengthening teeth.

Test examples

The physical and chemical indexes of the examples 1, 2 and 3 are as follows:

1. traits

The toothpaste prepared by the invention is light yellow, has proper viscosity, smooth and rich foam, is fine and uniform, has cool and comfortable mouthfeel, good stability and pleasant aroma.

2. Examination of pH value

Dipping a small amount of toothpaste with a moistened pH test paper, wherein the pH is 5.5-7.3

3. Room temperature standing test

The toothpaste is packaged in a transparent toothpaste tube, standing at room temperature for 6 months, and the color, smell, wiredrawing, viscosity and the like of the toothpaste are unchanged without layering.

4. Examination of foaming phenomenon

A small amount of finished toothpaste is put on the hands and rubbed in the hands, and the amount of foaming is observed to be moderate.

5. Examination for the Presence of excessively hard particles

A little of the formed toothpaste is coated on glass, and the glass is evenly pressed by fingers to find that no hard particles exist.

6. Checking for the presence of Water seepage

The toothpaste formed by squeezing points is placed on the raw edge paper and is uniformly spread by fingers, so that the toothpaste has less water seepage and better quality.

7. Irritation test and allergy test

The back of the mice was cut to remove hairs, and the toothpaste prepared in examples 1, 2 and 3 was applied to the cut-out portions, respectively, and compared with the non-applied portions, there was no irritation or allergic reaction.

1g of the toothpaste prepared in examples 1, 2 and 3 was applied to the hands of volunteers (15-65 years old, 100 persons), and no redness, rash or foaming appeared after 30 minutes.

8. Washing effect

The prepared toothpaste is gargled by selected volunteers (15-65 years old and 100 persons), the foams are found to be rich, and the volunteers generally reflect good mouthfeel, have comfortable oral cavity and do not have thirst phenomenon. After a period of continuous use, the teeth are white and firm, and the phenomena of gum bleeding and the like do not occur.

Claims

1. The gel toothpaste with the functions of resisting inflammation, sterilizing and strengthening teeth is characterized by comprising the following substances:

wherein the eucommia ulmoides leaf extracting solution is prepared by the following method:

weighing a proper amount of eucommia leaves, putting the eucommia leaves into a round-bottom flask, adding 20-30 times of water, soaking for 0.2-0.5h, putting the eucommia leaves into an electric heating jacket, extracting for 1.5-2.5h by using a continuous reflux extractor, adding 10-20 times of water for the 2 nd time, extracting for 1.0-1.5h, adding 8-15 times of water for the 3 rd time, extracting for 0.5-1h, filtering each time, combining filtrate, concentrating the volume of the filtrate to 3-6 times of the weight of the eucommia leaves, centrifuging for 15 minutes under a centrifuge of 2500r/min, and taking supernatant for later use;

the oleanolic acid extract is prepared by the following method:

weighing a proper amount of the olea europaea, soaking in water for 0.2-0.5h, heating, decocting and extracting for 3 times, adding 20-30 times of water for the 1 st time, extracting for 1.5-2.5h, adding 10-20 times of water for the 2 nd time, extracting for 1.0-1.5h, adding 10-15 times of water for the 3 rd time, extracting for 0.5-1h, filtering each time, combining filtrates, finally concentrating the volume of the filtrate to be 3-7 times of the weight of the olea europaea, centrifuging for 15 minutes under a 2500r/min centrifuge, and taking supernatant for later use;

the purslane extracting solution is prepared by the following method:

weighing proper amount of purslane, soaking in water for 0.2-0.5h, heating, decocting and extracting for 3 times, adding 18-25 times of water for the 1 st time, extracting for 1.5-2.5h, adding 10-18 times of water for the 2 nd time, extracting for 1.0-1.5h, adding 8-15 times of water for the 3 rd time, extracting for 0.5-1h, filtering each time, combining filtrates, finally concentrating the volume of the filtrate to 3-7 times of the weight of the purslane, centrifuging for 15 minutes under a 2500r/min centrifuge, and taking supernatant for later use;

the mint extracting solution is prepared by the following method:

weighing a proper amount of mint, putting the mint into a round-bottom flask, adding 20-30 times of water, soaking for 0.2-0.5h, putting the mint into an electric heating jacket, extracting for 1.5-2.5h by using a continuous reflux extractor, adding 10-20 times of water for the 2 nd time, extracting for 1.0-1.5h, adding 10-15 times of water for the 3 rd time, extracting for 0.5-1h, filtering each time, combining filtrates, concentrating the volume of the filtrate to be 3-7 times of the weight of the mint, centrifuging for 15 minutes by using a 2500r/min centrifuge, and taking supernatant for later use;

the eclipta alba extracting solution is prepared by the following method:

weighing a proper amount of eclipta alba, soaking in water for 0.2-0.5h, heating, decocting and extracting for 3 times, adding 20-30 times of water for the 1 st time, extracting for 1.5-2.5h, adding 10-18 times of water for the 2 nd time, extracting for 1.0-1.5h, adding 8-16 times of water for the 3 rd time, extracting for 0.5-1h, filtering each time, combining filtrates, finally concentrating the volume of the filtrate to be 3-6 times of the weight of the eclipta alba, centrifuging for 15 minutes under a 2500r/min centrifuge, and taking supernatant for later use;

the stevia extract is prepared by the following method:

weighing an appropriate amount of stevia rebaudiana Bertoni, soaking in water for 0.2-0.5h, heating, decocting and extracting for 3 times, adding 20-30 times of water for the 1 st time, extracting for 1.5-2.5h, adding 10-20 times of water for the 2 nd time, extracting for 1.0-1.5h, adding 5-15 times of water for the 3 rd time, extracting for 0.5-1h, filtering each time, combining filtrates, finally concentrating the volume of the filtrate to 3-6 times of the weight of the stevia rebaudiana Bertoni, centrifuging for 15 minutes under a 2500r/min centrifuge, and taking supernatant for later use;

the wild chrysanthemum extracting solution is prepared by the following method:

weighing a proper amount of wild chrysanthemum, putting the wild chrysanthemum into a round-bottom flask, adding 15-25 times of 70% ethanol solution, soaking for 0.2-0.5h, putting the flask into an electric heating jacket, extracting for 1.5-2.5h by using a continuous reflux extractor, adding 10-18 times of 70% ethanol solution for the 2 nd time, extracting for 1.0-1.5h, adding 8-12 times of 70% ethanol solution for the 3 rd time, extracting for 0.5-1h, filtering each time, combining filtrates, finally concentrating the volume of the filtrate to 3-6 times of the weight of the wild chrysanthemum, centrifuging for 15 minutes by using a centrifuge of 2500r/min, and taking supernatant for later use;

the scutellaria baicalensis extracting solution is prepared by the following method:

weighing a proper amount of scutellaria baicalensis coarse powder, soaking in water for 0.2-0.5h, heating, decocting and extracting for 3 times, adding 15-25 times of water for the 1 st time, extracting for 1.0-2.0h, adding 10-15 times of water for the 2 nd time, extracting for 1.0-1.5h, adding 8-15 times of water for the 3 rd time, extracting for 0.5-1h, filtering each time, combining filtrates, finally concentrating the volume of the filtrate to 2-5 times of the weight of scutellaria baicalensis, centrifuging for 15 minutes under a 2500r/min centrifuge, and taking a supernatant for later use;

the preparation method of the gel toothpaste with the anti-inflammatory, bactericidal and tooth-strengthening effects comprises the following steps: