CN111329903B

CN111329903B - Traditional Chinese medicine composition and application thereof

Info

Publication number: CN111329903B
Application number: CN202010342891.4A
Authority: CN
Inventors: 张瑞; 王英平; 郑斯文; 朴向民; 李婉莹
Original assignee: Jilin Agricultural University
Current assignee: Jilin Agricultural University
Priority date: 2020-04-27
Filing date: 2020-04-27
Publication date: 2021-11-30
Anticipated expiration: 2040-04-27
Also published as: CN111329903A

Abstract

The invention provides a traditional Chinese medicine composition and application thereof, and relates to the field of oral hygiene products. The traditional Chinese medicine composition comprises the following active ingredients in percentage by weight: the traditional Chinese medicine composition comprises, by weight, 1% -25% of asarum, 10% -50% of scutellaria baicalensis, 1% -25% of clove bark, 3% -55% of cimicifuga foetida, 10% -65% of purslane and 1% -35% of mint, has a positive promoting effect on improvement of oral problems such as toothache, periodontitis, dental plaque, gingival bleeding and oral ulcer, and is applied to oral care products and medicines for treating oral diseases so as to effectively prevent, treat or cure the oral diseases and guarantee oral health.

Description

Traditional Chinese medicine composition and application thereof

Technical Field

The invention relates to the field of oral hygiene products, and in particular relates to a traditional Chinese medicine composition and application thereof.

Background

At present, the common oral problems of people mainly comprise toothache, periodontitis, dental plaque, gingival bleeding, oral ulcer and the like.

Toothache is one of the most common symptoms of dental diseases in stomatology, and is manifested by red and swollen gums, pain induced by cold and hot stimuli, swelling of cheeks, and the like. Toothache is caused by infection of dental pulp (dental nerve) due to gingivitis, periodontitis, tooth decay, or broken teeth.

Periodontitis is a chronic nonspecific inflammation that is a lesion caused by bacterial invasion of the gingiva and periodontal tissues, resulting in loss of teeth in adults.

Dental plaque is a biofilm that gradually deposits on the surface of teeth and is composed of a large number of bacteria, intercellular substances, exfoliated epithelial cells, food debris, and the like.

Gingival bleeding refers to a small amount of bleeding that is either spontaneous or due to mild irritation of the gums. In general, chronic inflammation of the gums is a common cause of gingival bleeding, which is often seen in patients with periodontitis and gingivitis.

Canker sore refers to a disease in which the normal color, shape, integrity, function and the like of the mucosa of a certain part of the oral cavity are changed, and the specific symptoms are as follows: ulceration of the mouth and tongue, dry and cracked tongue, hoarseness, dry mouth and bitter mouth, followed by oral diseases such as lichen planus, stomatitis, recurrent aphtha and cheilitis.

The oral problems are often associated, multiple symptoms occur simultaneously, so that the oral pain of a patient is hard to endure, the eating is difficult and the patient cannot feel well, the oral problems are repeatedly attacked once the oral diseases are caused, multiple complications in vivo can be caused, the physical health and life of the patient are directly affected, antibiotics and the like are often contained in the treatment for the oral problems in the market, and certain side effects are caused.

Disclosure of Invention

The invention aims to provide a traditional Chinese medicine composition which has good effects of diminishing inflammation, easing pain, promoting healing of ulcer surfaces, stopping bleeding, inhibiting bacteria and the like, has positive promoting effect on improving oral problems such as toothache, periodontitis, dental plaque, gingival bleeding, oral ulcer and the like, does not contain antibiotics, is used for multi-target treatment and has small side effect.

The invention also aims to provide the application of the traditional Chinese medicine composition in oral care products, so as to effectively prevent or relieve the diseases, and simultaneously, the traditional Chinese medicine composition has a certain nursing effect and guarantees the health of the oral cavity.

The invention also aims to provide the application of the traditional Chinese medicine composition in the medicines for treating oral diseases, so as to effectively treat or cure the diseases and ensure the health of the oral cavity.

The technical problem to be solved by the invention is realized by adopting the following technical scheme.

The invention provides a traditional Chinese medicine composition, which comprises the following raw materials of active ingredients in percentage by weight:

1-25% of asarum, 10-50% of scutellaria, 1-25% of clove bark, 3-55% of cimicifuga foetida, 10-65% of purslane and 1-35% of mint.

The invention provides an application of the traditional Chinese medicine composition in an oral care product.

The invention provides application of the traditional Chinese medicine composition in medicines for treating oral diseases.

The traditional Chinese medicine composition and the application thereof have the beneficial effects that:

purslane is used as a monarch drug, scutellaria baicalensis and rhizoma cimicifugae are used as ministerial drugs, and the balance is used as an adjuvant. Purslane has cold nature and can cool blood and dissipate heat, relieve carbuncle swelling and heat toxin and expel pathogenic fire and toxin, baical skullcap root is used for clearing heat and drying dampness, purging fire and removing toxin to prevent deficient fire from flaming, largetrifoliolioliolioliolious bugbane rhizome is used for removing blood stasis and dredging collaterals and dispersing pathogenic toxin gathered in tooth bodies and gum flesh. Meanwhile, asarum and clove bark are used as adjuvant drugs for dispelling wind, diminishing inflammation and relieving pain, and mint is used for dispelling wind heat. The medicine has the functions of diminishing inflammation, easing pain, promoting the healing of ulcer surfaces, stopping bleeding, inhibiting bacteria and the like in an all-around and multi-target way, has positive promoting effect on improving the oral problems of toothache, periodontitis, dental plaque, gingival bleeding, oral ulcer and the like, and has small side effect.

Due to the cold nature of the scutellaria baicalensis and the purslane and the cold nature of the mint and the cimicifuga foetida, the whole medicinal property of the traditional Chinese medicine composition is effectively made to be cold rather than cold by adding the asarum, and the adverse effect of the cold nature on low immunity or pregnant women and the like is prevented. Meanwhile, under the condition of the proportion, the warm-natured asarum is added, so that the medicine effect of the traditional Chinese medicine composition is not influenced, and the traditional Chinese medicine composition is promoted to have better anti-inflammatory and analgesic effects, ulcer healing promotion, hemostasis and bacteriostasis effects.

Detailed Description

In order to make the objects, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below. The examples, in which specific conditions are not specified, were conducted under conventional conditions or conditions recommended by the manufacturer. The reagents or instruments used are not indicated by the manufacturer, and are all conventional products available commercially.

The following is a detailed description of the Chinese medicinal composition and its application in the embodiments of the present invention.

Preferably, the raw materials of the active ingredients of the traditional Chinese medicine composition comprise, by weight:

3-23% of asarum, 12-45% of scutellaria, 2-20% of clove bark, 5-50% of cimicifuga foetida, 15-60% of purslane and 2-30% of mint.

asarum herb 5-20 wt%, skullcap root 15-45 wt%, clove bark 5-20 wt%, cimicifuga rhizome 10-55 wt%, purslane 20-65 wt% and mint 5-29 wt%.

More preferably, the raw materials of the active ingredients of the traditional Chinese medicine composition comprise, by weight:

6% of asarum, 23% of scutellaria, 8% of clove bark, 21% of cimicifuga foetida, 32% of purslane and 10% of mint.

Wherein, Xixin is pungent in flavor and warm in nature, entering lung and kidney meridians. The traditional Chinese medicine theory considers that the asarum has the effects of relieving exterior syndrome, dispelling cold, dispelling wind and relieving pain, and modern pharmacological research proves that the asarum has various effects of relieving pain, resisting inflammation, resisting bacteria, resisting virus, local anesthesia and the like; the decoction of herba asari has surface anesthetic effect, and can be topically applied for promoting blood circulation, relieving pain, and promoting healing of ulcer.

Baikal skullcap root, bitter in taste and cold in nature, has the efficacies of clearing heat and drying dampness, purging fire and removing toxicity and stopping bleeding, and is reported in compendium of materia Medica: it is indicated for headache due to wind-heat and damp-heat, heat pain of running pig, cough due to fire, lung atrophy and throat smell, all blood loss. Scientific folk medicine and grass: it can be used for washing wound and preventing corrosion. Pharmacological research proves that the scutellaria has the effects of resisting bacteria, fungi, viruses and inflammation, and the like, and the clinical antibacterial property of the scutellaria is better than that of the coptis, and the scutellaria does not generate drug resistance.

The clove bark contains a large amount of eugenol, and the eugenol has good antibacterial effect, and can diminish inflammation, relieve pain and eliminate bad breath. Modern pharmacological experiments prove that the clove bark decoction has an inhibiting effect on staphylococcus, streptococcus, escherichia coli, typhoid bacillus, pseudomonas aeruginosa and the like.

Cimicifuga rhizome, rhizoma cimicifugae, with a cool nature and pungent and slightly bitter taste, enters lung, spleen and stomach meridians. Treatise on herb Property: it can be used for treating wind swelling and pain of mouth and teeth, root of tooth decay and foul smell, and pyogenic blood due to heat toxin. Eliminating obstruction of heart-lung wind-heat and toxic-heat and aphtha.

Purslane is cold in nature and sour in taste, has the functions of clearing heat, detoxifying and reducing swelling, and is mainly used for treating diseases such as dysentery, sores and ulcers.

Bo He is pungent in flavor and cool in nature, entering lung and liver meridians. Has effects of dispelling pathogenic wind heat, relieving sore throat, promoting eruption, and resolving stagnation, and can be used for treating wind-heat exterior syndrome, and sore throat.

As the traditional Chinese medicine considers that: wind-heat attacking the pathogenic wind-fire and attacking the teeth and gum, leading to the accumulation of pathogenic qi and blood, obstruction of qi and blood, and stagnation of blood in the meridians. Toothache can also be caused by up-flaming of deficient fire due to kidney yin deficiency, with teeth being the remainder of the bone. Toothache is caused by infection of dental pulp (dental nerve) due to gingivitis, periodontitis, tooth decay, or broken teeth.

Therefore, in the invention, the purslane is taken as a monarch drug, the scutellaria baicalensis and the cimicifuga foetida are taken as ministerial drugs, and the balance is taken as an adjuvant. Purslane has cold nature and can cool blood and dissipate heat, relieve carbuncle swelling and heat toxin and expel pathogenic fire and toxin, baical skullcap root is used for clearing heat and drying dampness, purging fire and removing toxin to prevent deficient fire from flaming, largetrifoliolioliolioliolious bugbane rhizome is used for removing blood stasis and dredging collaterals and dispersing pathogenic toxin gathered in tooth bodies and gum flesh. Meanwhile, asarum and clove bark are used as adjuvant drugs for dispelling wind, diminishing inflammation and relieving pain, and mint is used for dispelling wind heat. The medicine has the functions of diminishing inflammation, easing pain, promoting the healing of ulcer surfaces, stopping bleeding, inhibiting bacteria and the like in an all-around and multi-target way, has positive promoting effect on improving the oral problems of toothache, periodontitis, dental plaque, gingival bleeding, oral ulcer and the like, and has small side effect.

In a preferred embodiment of the invention, the active ingredients are prepared by the following method:

s1, soaking the raw materials, and decocting for 2-4 hours for the first time to obtain a first filtrate and a first filter residue.

Alternatively, the soaking is carried out by soaking the raw material in 9-11 times, for example, 10 times by weight of water for 3-5 hours, for example, 4 hours.

S2, decocting the first filter residue for 2-4 hours for the second time to obtain a second filtrate.

Optionally, the first residue is mixed with 4-6 times, for example 5 times, the weight of water of the first residue, and decocted.

And S3, combining the first filtrate and the second filtrate, concentrating the mixture to obtain a fluid extract, and drying the fluid extract.

Wherein, the drying is preferably spray drying, and the prepared active ingredients have small particle size, are fully mixed and are fluffy, thereby being convenient for subsequent mixing with auxiliary materials.

Wherein, the preparation of the effective components can be that the components in the raw materials are weighed according to the proportion, and the components are extracted by the method independently under the same parameter condition and then mixed. The raw materials can also be mixed after being weighed in proportion, and the extraction is carried out by adopting the method. And are not limited herein.

Optionally, the Chinese medicinal composition further comprises an auxiliary material, wherein the auxiliary material accounts for 50-99.9% of the composition, for example, the auxiliary material accounts for 50%, 55%, 60%, 65%, 70%, 75%, 80%, 85%, 90% or 95% of the composition, and the like, and the effective component accounts for 0.1-50% of the composition, for example, the effective component accounts for 1%, 3%, 5%, 10%, 15%, 20%, 25%, 30%, 40%, 45% or 50% of the composition.

Wherein the adjuvants comprise at least one of medicinal carrier, excipient, friction agent, purificant, wetting agent, adhesive, antiseptic, sweetener, aromatic, pigment and water. The auxiliary materials include, but are not limited to, the above raw materials.

Specifically, the auxiliary materials include, for example, acidic substances in mouthwash, desensitizing substance potassium nitrate; abrasives such as calcium phosphate, silica in toothpastes, and the like; thickeners such as PEG (polyethylene glycol), glycerin, and ethanol; xylitol, carrageenan, and the like; for example, in toothpaste or oral mucosa patches beeswax and carrageenan, CMC (carboxymethyl cellulose), HPMC (hydroxypropyl methyl cellulose), xanthan gum, etc. may be used, as well as flavors such as peppermint, spearmint, eucalyptus, carvone, wintergreen, cinnamon, citric acid, pine oil, etc.

The invention also provides application of the traditional Chinese medicine composition in oral care products.

Wherein, optionally, the oral care product comprises toothpaste, mouthwash, oral spray, troches, oral mucosal patches, chewing gum, or quick dissolve tablets.

When the oral care product is a toothpaste, the auxiliary materials preferably comprise 70% sorbitol, glycerol, hydrated silica, sodium carboxymethylcellulose, xylitol, sodium lauryl sulfate, flavoring essence and water.

When the oral care product is mouthwash, preferably, the auxiliary materials comprise glycerin, sodium fluoride, sodium citrate, citric acid, xylitol, tween-20, ethanol, cetyl pyridinium chloride, p-hydroxybenzoate, blending essence and water. The invention also provides application of the traditional Chinese medicine composition in medicines for treating oral diseases.

The medicine for treating oral diseases can be prepared into tablets, sprays, aqueous solutions, patches and the like according to the existing equipment and technology.

When the medicine for treating oral diseases is spray, preferably, the adjuvant comprises sodium chloride, EDTA (ethylene diamine tetraacetic acid), pH 6.5 sodium phosphate buffer solution, polyethoxy ether and water.

When the medicament for treating oral diseases is paste, the auxiliary materials are preferably polyethylene glycol, glycerol and calcium powder.

It should be noted that the traditional Chinese medicine oral products include, but are not limited to, oral medicines, oral care products, and also health products.

The features and properties of the present invention are described in further detail below with reference to examples.

Example 1

The effective components of the traditional Chinese medicine composition are prepared by the following method:

weighing 6 kg of asarum decoction pieces, 23 kg of scutellaria decoction pieces, 8 kg of clove bark decoction pieces, 21 kg of cimicifuga foetida decoction pieces, 32 kg of purslane decoction pieces and 10 kg of mint decoction pieces, putting the traditional Chinese medicine decoction pieces into a 1.5-cubic-meter extraction tank, adding 1000 kg of purified water, soaking for 4 hours, carrying out hot reflux extraction for 4 hours, filtering, adding 500 kg of water into residues, continuing hot reflux extraction for 4 hours, combining the two extracting solutions, concentrating to obtain a fluid extract, and carrying out spray drying to obtain the traditional Chinese medicine.

Example 2

The toothpaste comprises the following raw materials in percentage by mass:

the concentration of sorbitol is 70%, the concentration of glycerol is 30%, the concentration of sodium carboxymethylcellulose is 0.7%, the concentration of silicon dioxide is 18%, the concentration of sodium lauryl sulfate is 1.3%, the effective components of the traditional Chinese medicine composition provided in example 1 are 8%, and the concentration of purified water is 2%.

The toothpaste is prepared by the following method:

(1) weighing 70% sorbitol, glycerol, silicon dioxide, sodium carboxymethylcellulose, lauryl alcohol, effective components of the Chinese medicinal composition and purified water according to the proportion for later use;

(2) mixing sodium carboxymethylcellulose and glycerol to obtain glycerol colloid, mixing with the suspension of effective components of the Chinese medicinal composition, stirring, and homogenizing to obtain mixture A;

(3) mixing sorbitol and liquid sodium laurylsulfate (K)₁₂) Uniformly mixing with purified water, adding into the mixture A, and uniformly stirring to obtain a mixture B;

(4) then adding silicon dioxide into the mixture B, and uniformly stirring until the mixture B is transparent to obtain a mixture C;

(5) and finally adding essence, stirring uniformly, removing bubbles in vacuum, and canning.

Example 3

A mouth wash comprises the following raw materials in percentage by mass:

3% of glycerol, 0.04% of sodium fluoride, 0.6% of sodium citrate, 0.007% of citric acid, 0.015% of xylitol, 1.5% of tween (-20), 6% of ethanol, 0.008% of cetylpyridinium chloride, 0.20% of p-hydroxybenzoate, 0.10% of edible essence, 1.5% of the active ingredient of the traditional Chinese medicine composition provided in example 1 and 88.03% of purified water.

The toothpaste is prepared by the following method:

(1) adding the effective components of the Chinese medicinal composition into 60 times of purified water according to the proportion, and heating to dissolve the effective components; and (6) cooling.

(2) Cooling, sequentially adding sodium fluoride, sodium citrate, citric acid, sodium saccharin, tween-20, ethanol, cetyl pyridinium chloride, p-hydroxybenzoate, edible essence, glycerol, and purified water.

Example 4

A spray for treating oral diseases comprises the following raw materials in percentage by mass:

the effective components of the Chinese medicinal composition provided in example 1 are 1.2%, sodium chloride 0.9%, EDTA (ethylenediaminetetraacetic acid) 0.050%, sodium phosphate buffer solution with pH of 6.5 0.7%, polysorbate 0.60%, and water 96.55%.

The spray for treating oral diseases is prepared by the following method:

adding EDTA (ethylene diamine tetraacetic acid) and polysorbate into water according to a certain ratio, heating to 60-80 deg.C, adding effective components of the Chinese medicinal composition and sodium chloride, cooling to room temperature, adding sodium phosphate buffer solution (pH 6.5), mixing, canning, and sterilizing to obtain the Chinese medicinal oral care spray.

Example 5

A buccal tablet for treating oral diseases comprises the following raw materials in percentage by mass:

the traditional Chinese medicine composition provided in the embodiment 1 comprises 10% of active ingredients, 82% of medical starch, 5.8% of xylitol, 0.2% of magnesium stearate and 2% of talcum powder.

The buccal tablet for treating oral diseases is prepared by the following method:

(1) mixing the effective components of the Chinese medicinal composition, medical starch, xylitol, magnesium stearate, talcum powder, etc. in proportion, adding purified water, and stirring to reach the degree of hand-holding and agglomerating.

(2) And (3) preparing the stirred raw materials into particles by a mechanical or manual method, and drying.

(4) Making into tablet with tablet machine, packaging, and sterilizing.

Test examples

1) Example 2 was repeated to prepare a sufficient number of toothpastes, and 75 women and 75 men were randomly selected and equally divided into three groups as a test group, a control group 1 and a control group 2. A 6-month brushing test was performed twice daily.

Wherein each group comprises 5 men and women in the 15-25 year old interval, 5 men and women in the 26-35 year old interval, 5 men and women in the 36-45 year old interval, 5 men and women in the 46-55 year old interval, and 5 men and women in the 56-65 year old interval.

In the test examples, the toothpaste provided in example 2 of the present invention was used, and the toothpaste used in control 1 was different from the toothpaste provided in example 2 only in that it contained no active ingredient. The toothpaste used in control group 2 was a commercially available toothpaste.

The gingival index, GI, was tested as follows: the periodontal probe was placed at the gingival sulcus opening, gently touched to the gingival tissue and gently slid along the gingival margin to observe bleeding. The integration standard is 4 levels. 0 is normal gingiva, 1 is gingiva with slight edema, no bleeding is detected, 2 is recorded if bleeding is detected, and 3 is recorded if spontaneous bleeding tendency or ulcer formation is detected.

Probing for bleeding BPO, the test is as follows: the periodontal probe was gently probed at the bottom of the bag, and the probe was removed and observed for 10 s. After the visit, no bleeding occurred and the blood was recorded as negative, and after the visit, bleeding occurred and the blood was recorded as positive.

The mean GI and BPO% (+) of the teeth were recorded using a double blind test and the results are shown in table 1.

TABLE 1 test results

As can be seen from Table 1, the use of the toothpaste provided by the invention effectively improves GI and BOP of the teeth of the user, and effectively reduces the bleeding index of gingival inflammation.

Meanwhile, according to the comparison of the test group, the control group 1 and the control group 2, and the sensory perception that the user brushes teeth with other toothpastes, 76.7% of the people in the test group propose that the toothpaste provided by the invention is effective in alleviating the pain of teeth.

2) 45 wistar rats of 80g are selected and randomly divided into a blank control group, a positive control group and a tested drug group, and each group comprises 15 rats. The right hind foot sole of the rat was coated with normal saline 29 days before the positive control group, aspirin (0.10 g/kg bw in dose) was perfused into the stomach on day 30, the blank control group was coated with normal saline, and the test group was coated with the fluid extract of the composition provided in example 1 (the fluid extract was used here for easy application).

The position of each group of application is the position of the right hind foot of the rat, and the application is continuously carried out for 30 days. After the last administration for 1h, 0.1 ml/one of 1% carrageenan is injected subcutaneously into the right hind sole of the rat, the volume of the sole of each rat is measured 1, 3 and 6 hours after causing inflammation respectively, the volume of the sole of each rat is measured three times at the same part, the average value is taken, the volume change of the sole is observed, and the swelling rate of each group is calculated.

Wherein, the swelling rate is [ (volume of hind foot and volume of forefoot and volume of hind foot) multiplied by 100%. The test results are shown in table 2.

TABLE 2 Effect of test drugs on the swelling degree of the toes of rats: (

g/kg)

Note that P < 0.05 in comparison with the blank control group and P < 0.01 in comparison with the blank control group

As can be seen from the results in Table 2, the fluid extract of the tested composition has obvious inhibition effect on the toe swelling of rats, and the swelling rate of the tested composition is significantly different from that of a blank control group from 3h to 6 h. According to the result, the test sample rat foot sole swelling test result is positive, and the anti-inflammatory effect is good.

In conclusion, the traditional Chinese medicine composition and the application thereof disclosed by the embodiment of the invention have good effects of diminishing inflammation, easing pain, promoting healing of ulcer surfaces, stopping bleeding, inhibiting bacteria and the like, have a positive promoting effect on improving oral problems such as toothache, periodontitis, dental plaque, gingival bleeding, oral ulcer and the like, do not contain antibiotics, are used for multi-target treatment and have small side effect.

The embodiments described above are some, but not all embodiments of the invention. The detailed description of the embodiments of the present invention is not intended to limit the scope of the invention as claimed, but is merely representative of selected embodiments of the invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

Claims

1. The traditional Chinese medicine composition is characterized by comprising the following raw materials of effective components in percentage by weight:

2. The traditional Chinese medicine composition as claimed in claim 1, wherein the raw materials of the effective components of the traditional Chinese medicine composition comprise, by weight:

3. The traditional Chinese medicine composition as claimed in claim 1, wherein the raw materials of the effective components of the traditional Chinese medicine composition comprise, by weight:

4. The traditional Chinese medicine composition as claimed in claim 1, wherein the raw materials of the effective components of the traditional Chinese medicine composition comprise, by weight:

5. The traditional Chinese medicine composition according to any one of claims 1 to 4, wherein the effective ingredients are prepared by the following method: soaking the raw materials, and decocting for 2-4h for the first time to obtain a first filtrate and a first filter residue;

decocting the first filter residue for 2-4h for the second time to obtain a second filtrate;

mixing the first filtrate and the second filtrate, concentrating to obtain fluid extract, and drying.

6. The traditional Chinese medicine composition according to claim 5, further comprising an auxiliary material, wherein the auxiliary material accounts for 50-99.9% of the composition, and the effective component accounts for 0.1-50% of the composition.

7. The composition of claim 6, wherein the excipient comprises at least one of a pharmaceutical carrier and an excipient.

8. The composition of claim 6, wherein the excipients comprise at least one of an abrasive, a cleansing agent, a wetting agent, a preservative, a sweetener, an aromatic, a pigment, and water.

9. The use of the Chinese medicinal composition of any one of claims 1-8 in an oral care product.

10. The use of claim 9, wherein the oral care product comprises toothpaste, mouthwash, mouth spray, a troche, a patch for oral mucosa, a chewing gum, or a quick dissolve tablet.

11. Use of the Chinese medicinal composition of any one of claims 1-8 in the preparation of a medicament for the treatment of an oral disease.