CN101574445B

CN101574445B - Traditional Chinese medicine composition with oral health efficacy

Info

Publication number: CN101574445B
Application number: CN2008100181548A
Authority: CN
Inventors: 党化宁
Original assignee: Individual
Current assignee: Individual
Priority date: 2008-05-08
Filing date: 2008-05-08
Publication date: 2012-04-25
Anticipated expiration: 2028-05-08
Also published as: CN101574445A

Abstract

The invention relates to the technical field of traditional Chinese medicine application, in particular to a traditional Chinese medicine composition with the oral health efficacy, overcoming the defects that the prior oral health products have single and unfavorable curative effect. The traditional Chinese medicine composition with the oral health efficacy comprises the following medicinal materials by weight percentage: 10 to 20 of cimicifuga foetidae, 10 to 20 of angelica dahurica, 5 to 15 of asarum, 10 to 20 of mint, 10 to 20 of nutgall, 10 to 25 of cortex lycii radicis, 5 to 15 of pepper and 2 to 10 of borneol which are prepared into product medicament forms, such as mouthwash, toothpaste, chewing gum, spray, paste, cream, chewing tablets, lozenges, and the like. Compared with the prior art, the product can effectively prevent canker sore and has the efficacy of rapidly curing the canker sore.

Description

A kind of Chinese medicine composition with oral health efficacy

Affiliated field:

The present invention relates to the Chinese medicine applied technical field, be specifically related to a kind of Chinese medicine composition with oral health efficacy.

Background technology:

The complex structure in oral cavity, because temperature, humidity be fit to, and the reason such as remaining of food debris, cause the oral cavity bacterium breeding vigorous.Owing to have a large amount of dental calculuss, tartar etc. in the oral cavity, they contain a large amount of oral cavity bacteriums, are easy to generate volatile sulfide again, cause halitosis, also are easy to generate organic acid such as lactic acid, and the dissolving tooth forms dental disorders such as decayed tooth, brings out the gingiva inflammation.If continue bad oral sanitary habit, gingiva will further be received destruction, form periodontitis, red swelling of gingiva, pain, odontoseisis, pyorrhea occur, expose symptoms such as gingiva and halitosis.Periodontal abscess can increase the weight of the destruction of periodontal tissue, causes symptoms such as general malaise, generation, the violent jumping pain of trouble tooth.Along with increasing the weight of of the state of an illness, alveolar bone makes loosening, the displacement of odontogeny also in regression, forms periodontal pocket; When accompanying infection causes inflammation, occur having an intense pain, symptom such as masticatory atonia, halitosis.Periodontal is not only the first cause that causes loss of tooth, influences important organ functions such as heart, lung, kidney especially, causes the important origin cause of formation of the high disease of various mortality rates.Research shows that the enzyme that periodontal bacteria produced can impel thrombus in vivo to form.Periodontal bacteria gets into blood, can impel human body to produce a kind of effect and be similar to hematoblastic gluey albumen, forms thrombosis, and occluding vascular causes heart disease and stroke.There is report to claim that the probability of patients with periodontitis generation coronary heart disease and apoplexy is respectively 1.4 times and 2.1 times of the normal person of periodontal.Old people's suffer from an inflammation of the lungs is in close relations with periodontal.Intraoral a large amount of antibacterial can be inhaled into pulmonary, causes pneumonia.Periodontal disease takes place in oral hygiene difference person easily, and its probability that chronic pulmonary infection and pulmonary function reduction take place is 2 times of the good person of oral hygiene.Helicobacter pylori is the pathogenic bacterium of chronic gastritis, gastric ulcer even gastric cancer.In recent years, researcher detects helicobacter pylori in dental plaque and saliva, and the recall rate of the helicobacter pylori person that is higher than the periodontal health in periodontal disease patient's the bacterial plaque.In addition, periodontal can also cause multiple inflammation as infection focus, like rheumatic or rheumatoid arthritis, glomerulonephritis, iridocyclitis and some dermatosis etc.Oral disease has a strong impact on orthobiosis of the people and healthy.

In order to prevent oral disease, multiple Chinese herbal toothpaste and collutory have appearred in China, but because medication is single, contained active constituent content is very low, and is not good enough to oral cavity various diseases therapeutic effect.Various Chinese herbal toothpastes, active constituent content is low, and is not good to the oral cavity disease therapeuticing effect, particularly when suffering from oral disease or odontopathy, can't use.Part toothpaste restricted application only is applicable to low fluorine or geographic school age population of right fluorine and other dental caries Susceptible population like toothpaste with fluoride and fluoride mouthwash.The collutory of market sale; Main component is a chemical bactericide; Comprise hibitane, phenolic compound, hydrogen peroxide, 0.01%～0.03% metronidazole collutory, 0.06% tetracycline collutory, 0.01%～0.03% nitrofural collutory, 1.64% stannous fluoride solution, Sanguinarine collutory and zinc salt collutory etc., curative effect is single.Life-time service has the medicine collutory of bactericidal effect, also can cause the antibacterial of a certain kind excessively to be suppressed, thereby cause dysbacteriosis in the oral cavity, is unfavorable for oral health on the contrary.In addition, the life-time service hibitane also is prone to make tooth and oral mucosal surface painted, the sense of taste of taste bud is reduced, and suppress the secretion of saliva, causes malaise symptoms such as xerostomia, causalgia.Application number is 200710054542.7 invention, and a kind of Chinese medicine composition of removing halitosis and preparation method thereof is provided, but curative effect only is confined to remove halitosis.Therefore prior art exists the single and unfavorable problem of effect of curative effect.

Summary of the invention:

The purpose of this invention is to provide a kind of Chinese medicine composition, with the single and unfavorable shortcoming of effect of curative effect that overcomes oral health care product with oral health efficacy.

A kind of Chinese medicine composition with oral health efficacy comprises following with medicine materials in portions by weight: Rhizoma Cimicifugae 10～20%, the Radix Angelicae Dahuricae 10～20%; Herba Asari 5～15%, Herba Menthae 10～20%, Galla Chinensis 10～20%; Cortex Lycii 10～25%, Pericarpium Zanthoxyli 5～15%, Borneolum Syntheticum 2～10%.

Be prepared into product forms such as collutory, toothpaste, chewing gum, spray, cream, frost, chewable tablet and buccal tablet.

Compared with prior art, the present invention follows the theoretical prescription of Chinese medicine monarch, and prescription is a monarch drug with Rhizoma Cimicifugae, Herba Asari, the Radix Angelicae Dahuricae; With Herba Menthae, Galla Chinensis, Cortex Lycii, Pericarpium Zanthoxyli, Borneolum Syntheticum is ministerial drug, and Rhizoma Cimicifugae has elevate a turnable ladder and sends out effects such as reaching heat-clearing and toxic substances removing thoroughly, and the Radix Angelicae Dahuricae has the effect that detumescence relieves the pain; Herba Asari has the effect of wind-expelling pain-stopping; Herba Menthae has dispelling wind, dispels the heat, wards off dirty, antidotal effect, and Galla Chinensis has hemostasis antidotal effect, and Cortex Lycii has the effect that removing heat from blood removes steaming, lung heat clearing pathogenic fire reducing; Borneolum Syntheticum has the refreshment of having one's ideas straightened out, the effect of loose stagnated fire, reducing swelling and alleviating pain, and Pericarpium Zanthoxyli has dehumidifying, pain relieving, parasite killing.Various components cooperatively interact, and make that these article have heat clearing away, detoxifcation, antiinflammatory, relieve the pain, the repercussive curative effect, and can reach removing foul breath, remove the effect of halitosis.The traditional Chinese medical science thinks that aphtha has the branch of deficiency and excess, and idol is given birth to aphtha person and is mostly excess-fire; It is common with hyperactivity of fire caused by deficiency of YIN to send out the author repeatedly, and the inducement that the oral ulcer patient that love is shown effect repeatedly should find out morbidity as far as possible is (like spiritual hypertonicity, gastrointestinal dysfunction; It is pungent etc. to lack vitamin or surfeit in the diet); Carry out prophylactic treatment simultaneously, these article both can effectively prevent oral ulcer, simultaneously the ulcer that has taken place were had the effect of rapid healing.

The specific embodiment:

To combine embodiment that the present invention is done explanation at length below.

The additive that Chinese medicine composition can be used as various oral health care products uses, and is processed into various dosage forms as required.

Embodiment 1:

Get 15 parts of the Rhizoma Cimicifugaes of parts by weight, 15 parts of the Radixs Angelicae Dahuricae, 10 parts of Herba Asaris, 15 parts of Herba Menthaes; 15 parts of Galla Chinensiss, 15 parts of Cortex Lycii, 10 parts in Pericarpium Zanthoxyli, 5 parts of Borneolum Syntheticums; Pulverize the back and mix, the decocting that adds 6 times of raw material weights boiled 4 hours, and behind the separating liquid, medicinal residues add 4 times of water gagings and decocted 3 hours.Twice decoction liquor merged filters, be diluted to 20 times of amounts after, the antibacterial bottling is promptly processed water preparation, i.e. collutory.

Embodiment 2:

Get 10 parts of the Rhizoma Cimicifugaes of parts by weight, 20 parts of the Radixs Angelicae Dahuricae, 15 parts of Herba Asaris, 20 parts of Herba Menthaes; 15 parts of Galla Chinensiss, 10 parts of Cortex Lycii, 10 parts in Pericarpium Zanthoxyli, 5 parts of Borneolum Syntheticums; Pulverize the back and mix, the decocting that adds 10 times of raw material weights boiled 4 hours, and behind the separating liquid, medicinal residues add 6 times of water gagings and decocted 3 hours.Twice decoction liquor merged filters, be diluted to 10 times of amounts after, the antibacterial bottling is promptly processed the concentrated type water preparation, i.e. the concentrated type collutory.

Embodiment 3:

Get 15 parts of the Rhizoma Cimicifugaes of parts by weight, 10 parts of the Radixs Angelicae Dahuricae, 5 parts of Herba Asaris, 15 parts of Herba Menthaes; 10 parts of Galla Chinensiss, 20 parts of Cortex Lycii, 15 parts in Pericarpium Zanthoxyli, 10 parts of Borneolum Syntheticums; Pulverize the back and mix, the decocting that adds 6 times of raw material weights boiled 4 hours, and behind the separating liquid, medicinal residues add 5 times of water gagings and decocted 3 hours.Twice decoction liquor is filtered, concentrated.Method for preparing by conventional patch prepares.

Embodiment 4:

Get 20 parts of the Rhizoma Cimicifugaes of parts by weight, 20 parts of the Radixs Angelicae Dahuricae, 5 parts of Herba Asaris, 10 parts of Herba Menthaes; 10 parts of Galla Chinensiss, 10 parts of Cortex Lycii, 15 parts in Pericarpium Zanthoxyli, 10 parts of Borneolum Syntheticums; Pulverize the back and mix, the decocting that adds 8 times of raw material weights boiled 4 hours, and behind the separating liquid, medicinal residues add 5 times of water gagings and decocted 3 hours.Twice decoction liquor is filtered, and concentrate drying becomes powder subsequent use.

18 parts of mixing of 25 parts of 8 parts of 30 parts of vinyl acetates, esterases, polyisobutylene, Saccharum Sinensis Roxb. with weight fraction; Fully add hot milling, add 1 part of acetyl group methyl ricinoleate, 12 parts of calcium carbonate then, again through mixing; In the mixture that obtains, add 6 parts in above-mentioned subsequent use powder; Again after fully mixing, send and roll that to prolong machine further mixing, press specific thickness then and cut into slices and promptly get the oral cavity health chewing gum.

Embodiment 5:

Get 10 parts of the Rhizoma Cimicifugaes of parts by weight, 20 parts of the Radixs Angelicae Dahuricae, 15 parts of Herba Asaris, 15 parts of Herba Menthaes; 10 parts of Galla Chinensiss, 20 parts of Cortex Lycii, 5 parts in Pericarpium Zanthoxyli, 5 parts of Borneolum Syntheticums; Pulverize the back and mix, the water decocting that adds 12 times of raw material weights boiled 4 hours, and behind the separating liquid, medicinal residues add 6 times of water gagings and decocted 3 hours.Twice decoction liquor is filtered, and concentrate drying becomes powder subsequent use.

0.5 part of carboxymethyl cellulose, 0.5 part of hydroxyethyl-cellulose with weight fraction; After adding 25 parts of water heating for dissolving; Add 2 parts of sodium lauryl sulfates, 15 parts of glycerol, 50 parts of natural whitings, 1 part of stirring of essence successively, treat that mastic evenly after, add 6 parts in subsequent use powder again; Stir, can pack after the cooling.

Embodiment 6:

Get 12 parts of the Rhizoma Cimicifugaes of parts by weight, 18 parts of the Radixs Angelicae Dahuricae, 10 parts of Herba Asaris, 15 parts of Herba Menthaes; 15 parts of Galla Chinensiss, 10 parts of Cortex Lycii, 10 parts in Pericarpium Zanthoxyli, 5 parts of Borneolum Syntheticums; Pulverize the back and mix, the decocting that adds 10 times of raw material weights boiled 4 hours, and behind the separating liquid, medicinal residues add 5 times of water gagings and decocted 3 hours.Twice decoction liquor is filtered, be concentrated into do after, process powder by conventional formulation technology, the antibacterial pack.

Embodiment 7:

Get 16 parts of the Rhizoma Cimicifugaes of parts by weight, 14 parts of the Radixs Angelicae Dahuricae, 12 parts of Herba Asaris, 18 parts of Herba Menthaes; 20 parts of Galla Chinensiss, 20 parts of Cortex Lycii, 15 parts in Pericarpium Zanthoxyli, 2 parts of Borneolum Syntheticums; Pulverize the back and mix, the decocting that adds 10 times of raw material weights boiled 4 hours, and behind the separating liquid, medicinal residues add 5 times of water gagings and decocted 3 hours.Twice decoction liquor is filtered, be concentrated into drying.

Method for preparing by conventional chewable tablet prepares: add 15 parts in lecithin, 40 parts in mannitol is ground into powder, adds adjuvant such as polyvinyl pyrrolidone again and carries out tabletting.Every drug 0.5 gram, per day for adults 2～3 grams get final product.

Method for using: product of the present invention is an oral cavity medicine, can be coated with, gargle, and medication is at affected area.The product of embodiment 1,2 usefulness of gargling, the product of embodiment 3 directly is attached to the affected part, and the toothpaste among embodiment 4 and the embodiment 5, chewing gum absorb to stimulate the oral mucosa mode through brushing teeth or mastication, and the powder of embodiment 6 is spread across the affected part; The product of embodiment 7 is chewed treatment.

Claims

1. the Chinese medicine composition with oral health efficacy is processed with medicine materials in portions by weight by following: Rhizoma Cimicifugae 10～20%, the Radix Angelicae Dahuricae 10～20%; Herba Asari 5～15%, Herba Menthae 10～20%, Galla Chinensis 10～20%; Cortex Lycii 10～25%, Pericarpium Zanthoxyli 5～15%, Borneolum Syntheticum 2～10%.

2. a kind of Chinese medicine composition with oral health efficacy as claimed in claim 1 is characterized in that: be prepared into collutory, toothpaste, chewing gum, spray, cream, frost, chewable tablet and buccal tablet.