CN114129637A - Pharmaceutical composition for treating dental diseases, preparation method and application - Google Patents
Pharmaceutical composition for treating dental diseases, preparation method and application Download PDFInfo
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- CN114129637A CN114129637A CN202111421927.9A CN202111421927A CN114129637A CN 114129637 A CN114129637 A CN 114129637A CN 202111421927 A CN202111421927 A CN 202111421927A CN 114129637 A CN114129637 A CN 114129637A
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- 239000008194 pharmaceutical composition Substances 0.000 title claims abstract description 26
- 208000014151 Stomatognathic disease Diseases 0.000 title claims description 22
- 238000002360 preparation method Methods 0.000 title abstract description 10
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 153
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims abstract description 24
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims abstract description 24
- 239000008108 microcrystalline cellulose Substances 0.000 claims abstract description 24
- 229940016286 microcrystalline cellulose Drugs 0.000 claims abstract description 24
- 239000003814 drug Substances 0.000 claims abstract description 19
- DTGKSKDOIYIVQL-WEDXCCLWSA-N (+)-borneol Chemical compound C1C[C@@]2(C)[C@@H](O)C[C@@H]1C2(C)C DTGKSKDOIYIVQL-WEDXCCLWSA-N 0.000 claims abstract description 11
- REPVLJRCJUVQFA-UHFFFAOYSA-N (-)-isopinocampheol Natural products C1C(O)C(C)C2C(C)(C)C1C2 REPVLJRCJUVQFA-UHFFFAOYSA-N 0.000 claims abstract description 11
- 241000758794 Asarum Species 0.000 claims abstract description 11
- 235000006679 Mentha X verticillata Nutrition 0.000 claims abstract description 11
- 235000002899 Mentha suaveolens Nutrition 0.000 claims abstract description 11
- 235000001636 Mentha x rotundifolia Nutrition 0.000 claims abstract description 11
- 229940116229 borneol Drugs 0.000 claims abstract description 11
- CKDOCTFBFTVPSN-UHFFFAOYSA-N borneol Natural products C1CC2(C)C(C)CC1C2(C)C CKDOCTFBFTVPSN-UHFFFAOYSA-N 0.000 claims abstract description 11
- DTGKSKDOIYIVQL-UHFFFAOYSA-N dl-isoborneol Natural products C1CC2(C)C(O)CC1C2(C)C DTGKSKDOIYIVQL-UHFFFAOYSA-N 0.000 claims abstract description 11
- 235000002566 Capsicum Nutrition 0.000 claims abstract description 10
- 239000006002 Pepper Substances 0.000 claims abstract description 10
- 235000016761 Piper aduncum Nutrition 0.000 claims abstract description 10
- 235000017804 Piper guineense Nutrition 0.000 claims abstract description 10
- 235000008184 Piper nigrum Nutrition 0.000 claims abstract description 10
- 235000011187 glycerol Nutrition 0.000 claims description 55
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 12
- 238000001035 drying Methods 0.000 claims description 12
- 238000000034 method Methods 0.000 claims description 12
- 239000002994 raw material Substances 0.000 claims description 12
- 241000722363 Piper Species 0.000 claims description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 9
- 239000004615 ingredient Substances 0.000 claims description 7
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 claims description 6
- 238000001914 filtration Methods 0.000 claims description 6
- 238000010438 heat treatment Methods 0.000 claims description 6
- 239000007787 solid Substances 0.000 claims description 6
- 238000003756 stirring Methods 0.000 claims description 6
- 239000003292 glue Substances 0.000 claims description 5
- 239000002775 capsule Substances 0.000 claims description 4
- 238000010828 elution Methods 0.000 claims description 4
- 208000007565 gingivitis Diseases 0.000 claims description 4
- 230000003301 hydrolyzing effect Effects 0.000 claims description 4
- 241000213006 Angelica dahurica Species 0.000 claims description 3
- 108010059892 Cellulase Proteins 0.000 claims description 3
- 229920001131 Pulp (paper) Polymers 0.000 claims description 3
- 201000004328 Pulpitis Diseases 0.000 claims description 3
- 206010037464 Pulpitis dental Diseases 0.000 claims description 3
- 239000002253 acid Substances 0.000 claims description 3
- 239000001569 carbon dioxide Substances 0.000 claims description 3
- 229910002092 carbon dioxide Inorganic materials 0.000 claims description 3
- 229940106157 cellulase Drugs 0.000 claims description 3
- 238000006243 chemical reaction Methods 0.000 claims description 3
- 238000004140 cleaning Methods 0.000 claims description 3
- 238000001816 cooling Methods 0.000 claims description 3
- 208000002925 dental caries Diseases 0.000 claims description 3
- 239000003085 diluting agent Substances 0.000 claims description 3
- 238000004821 distillation Methods 0.000 claims description 3
- 239000012153 distilled water Substances 0.000 claims description 3
- 239000011268 mixed slurry Substances 0.000 claims description 3
- 238000002156 mixing Methods 0.000 claims description 3
- 238000004806 packaging method and process Methods 0.000 claims description 3
- 201000001245 periodontitis Diseases 0.000 claims description 3
- 238000004321 preservation Methods 0.000 claims description 3
- 239000000376 reactant Substances 0.000 claims description 3
- 239000002904 solvent Substances 0.000 claims description 3
- 230000001954 sterilising effect Effects 0.000 claims description 3
- 238000005406 washing Methods 0.000 claims description 3
- 238000005303 weighing Methods 0.000 claims description 3
- 210000004195 gingiva Anatomy 0.000 claims description 2
- 239000000463 material Substances 0.000 claims description 2
- 238000004513 sizing Methods 0.000 claims description 2
- 208000018035 Dental disease Diseases 0.000 claims 4
- 238000004519 manufacturing process Methods 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 238000000643 oven drying Methods 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 239000000203 mixture Substances 0.000 abstract description 4
- 241000894006 Bacteria Species 0.000 abstract description 3
- 239000012466 permeate Substances 0.000 abstract description 3
- 210000003296 saliva Anatomy 0.000 abstract description 3
- 206010061218 Inflammation Diseases 0.000 abstract description 2
- 230000004054 inflammatory process Effects 0.000 abstract description 2
- 244000203593 Piper nigrum Species 0.000 abstract 1
- 230000000857 drug effect Effects 0.000 abstract 1
- 239000000047 product Substances 0.000 description 9
- 229940079593 drug Drugs 0.000 description 3
- 230000007547 defect Effects 0.000 description 2
- 208000004371 toothache Diseases 0.000 description 2
- 241000906579 Actaea cimicifuga Species 0.000 description 1
- 235000007650 Aralia spinosa Nutrition 0.000 description 1
- 241000949456 Zanthoxylum Species 0.000 description 1
- 239000004568 cement Substances 0.000 description 1
- 235000005301 cimicifuga racemosa Nutrition 0.000 description 1
- 239000000645 desinfectant Substances 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 230000007721 medicinal effect Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000008092 positive effect Effects 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
- A61K35/64—Insects, e.g. bees, wasps or fleas
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/26—Aristolochiaceae (Birthwort family), e.g. heartleaf
- A61K36/268—Asarum (wild ginger)
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/534—Mentha (mint)
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/758—Zanthoxylum, e.g. pricklyash
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
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- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
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- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0063—Periodont
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- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
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Abstract
The invention belongs to the technical field of traditional Chinese medicine compositions, and discloses a pharmaceutical composition for treating odontopathy, a preparation method and an application thereof, wherein the pharmaceutical composition for treating odontopathy comprises, by mass, 25-30 parts of radix angelicae, 10-15 parts of pepper, 20-25 parts of borneol, 10-15 parts of asarum, 10-15 parts of gallnut, 5-8 parts of cortex lycii radicis, 5-8 parts of cimicifugae foetidae, 5-8 parts of mint, and 1-5 parts of microcrystalline cellulose and glycerol. The pharmaceutical composition for treating odontopathy provided by the invention is in a daub shape, can be pasted and stay at the affected part, gradually permeates into the focus, is not easy to dissolve and fall off, and can be kept for several hours, so that the pharmaceutical composition for treating odontopathy can fully exert the drug effect, and the affected inflammation part is promoted to be improved as soon as possible; solves the problem that the prior external medicine for odontopathy can be quickly washed away by saliva, so that the infected part is exposed in bacteria and is not suitable for rehabilitation.
Description
Technical Field
The invention belongs to the technical field of traditional Chinese medicine compositions, and particularly relates to a pharmaceutical composition for treating odontopathy, a preparation method and application thereof.
Background
Currently, toothache is a common disease, such as: caries, pulpitis, periodontitis, periapicalitis, gingivitis, etc. The treatment methods of the dental diseases mainly comprise external use medicines, internal use medicines, dental treatment and the like. Especially, when the medicine is externally used, the medicine is usually washed away quickly due to a large amount of oral liquid, so that the infected part is exposed in bacteria, and the infected part is not suitable for recovery. Therefore, there is a need for a new pharmaceutical composition for treating dental diseases and a preparation method thereof, which can overcome the disadvantages of the prior art.
Through the analysis, the existing technology for treating toothache on the market has the following problems and defects: the existing external medicine for treating odontopathy is usually washed away by saliva quickly, so that infected parts are exposed in bacteria, and the infected parts are not suitable for rehabilitation.
The significance of solving the problems and the defects is as follows: the external medicine for treating odontopathy can not be easily melted by saliva in daily life, so that the treatment time is shortened, the treatment effect is improved, and the duration of odontopathy is reduced, thereby providing convenient service for patients.
Disclosure of Invention
Aiming at the problems in the prior art, the invention provides a pharmaceutical composition for treating dental diseases, a preparation method and application thereof.
The invention is realized in such a way, the pharmaceutical composition for treating odontopathy comprises 25-30 parts of radix angelicae, 10-15 parts of pepper, 20-25 parts of borneol, 10-15 parts of asarum, 10-15 parts of gallnut, 5-8 parts of cortex lycii radicis, 5-8 parts of cimicifugae foetidae, 5-8 parts of mint and 1-5 parts of other ingredients in parts by mass;
the other types of ingredients include microcrystalline cellulose and glycerin.
Another object of the present invention is to provide a method for preparing a pharmaceutical composition for treating dental diseases, which comprises the steps of:
step one, obtaining a glycerol raw material, and purifying the obtained glycerol raw material to obtain purified glycerol; simultaneously preparing microcrystalline cellulose;
weighing radix angelicae, pepper, borneol, asarum, gallnut, cortex lycii radicis, cimicifugae foetidae, mint, microcrystalline cellulose and glycerol in proportion;
step three, cleaning and drying the weighed angelica dahurica, pepper, borneol, asarum, gallnut, cortex lycii radicis, cimicifugae foetidae and mint, and adding 500 ml of clear water to decoct for 1 hour;
step four, adding 1000 ml of clear water and the capsule glue solution again, decocting for 2 to 3 hours, filtering out medicine residues, and putting the medicine solution into a container for natural cooling to obtain a paste; subpackaging the paste into dough, sterilizing, and packaging.
Further, in the step one, the purifying the obtained glycerin raw material to obtain purified glycerin includes:
mixing a glycerol raw material with a diluent to obtain diluted glycerol, and adjusting the pH value of the diluted glycerol by using an acid-base regulator;
standing and layering the glycerol after the pH value is adjusted to obtain a primarily filtered glycerol product; heating and stirring the primarily filtered glycerol product, and removing the upper layer to obtain a secondarily filtered glycerol product;
separating the glycerol product after the secondary filtration by using a liquefaction chromatogram, and collecting the eluted components of the glycerol; and (3) recovering the solvent from the collected glycerin elution component by low-temperature reduced pressure distillation to obtain the high-purity glycerin.
Further, the pH regulator may be a dilute acid solution or carbon dioxide.
Further, in the second step, the preparing of the microcrystalline cellulose comprises:
(1) heating the hydrochloric acid solution to 45 ℃, adding bleached wood pulp into the heated hydrochloric acid solution while stirring, and carrying out heat preservation reaction for a period of time;
(2) adding pre-dissolved cellulase into the reactant, and hydrolyzing; obtaining mixed slurry;
(3) ultrasonically crushing, rinsing and drying the mixed sizing material to obtain a microcrystalline cellulose solid; and washing the microcrystalline cellulose solid by using triple distilled water, and drying to obtain the microcrystalline cellulose.
Further, the hydrolysis comprises: hydrolyzing at 70-90 deg.C for 1 hr.
Further, the drying includes: drying at 60 deg.C.
The invention also aims to provide application of the pharmaceutical composition for treating dental diseases in preparation of medicines for treating or improving dental diseases.
The invention also aims to provide application of the pharmaceutical composition for treating dental diseases in preparing daily care products for preventing dental diseases.
Further, the dental diseases include caries, pulpitis, periodontitis, periapicalitis and gingivitis.
Further, the application further comprises:
the pharmaceutical composition for treating dental diseases is cut into a proper shape and directly applied to diseased gingiva, or applied to diseased teeth, or applied to diseased slits between teeth.
By combining all the technical schemes, the invention has the advantages and positive effects that: the medicinal composition for treating the dental diseases is in a daub shape, can be pasted and stay at the diseased part, gradually permeates into the focus, is not easy to dissolve and fall off, and can be kept for several hours, so that the medicinal composition for treating the dental diseases can fully exert the medicinal effect, and the diseased inflammation part is promoted to be improved as soon as possible.
Drawings
In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the drawings needed to be used in the embodiments of the present invention will be briefly described below, and it is obvious that the drawings described below are only some embodiments of the present invention, and it is obvious for those skilled in the art that other drawings can be obtained according to the drawings without creative efforts.
FIG. 1 is a flow chart of a method for preparing a pharmaceutical composition for treating dental diseases according to an embodiment of the present invention.
Fig. 2 is a flow chart of a method for purifying the obtained glycerin raw material to obtain purified glycerin according to an embodiment of the present invention.
FIG. 3 is a flow chart of a method for preparing microcrystalline cellulose according to an embodiment of the present invention.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention is further described in detail with reference to the following embodiments. It should be understood that the specific embodiments described herein are merely illustrative of the invention and are not intended to limit the invention.
In order to solve the problems in the prior art, the invention provides a pharmaceutical composition for treating dental diseases, a preparation method and a use method thereof, and the invention is described in detail with reference to the accompanying drawings.
The pharmaceutical composition for treating odontopathy provided by the embodiment of the invention is composed of 25-30 parts of radix angelicae, 10-15 parts of pepper, 20-25 parts of borneol, 10-15 parts of asarum, 10-15 parts of gallnut, 5-8 parts of cortex lycii radicis, 5-8 parts of cimicifugae foetidae, 5-8 parts of mint and 1-5 parts of other ingredients in parts by mass;
other types of furnish provided by embodiments of the present invention include microcrystalline cellulose and glycerin.
As shown in fig. 1, the preparation method of the pharmaceutical composition for treating dental diseases provided by the embodiment of the present invention comprises the following steps:
s101, obtaining a glycerol raw material, and purifying the obtained glycerol raw material to obtain purified glycerol; simultaneously preparing microcrystalline cellulose;
s102, weighing radix angelicae, pepper, borneol, asarum, gallnut, cortex lycii radicis, cimicifugae foetidae, mint, microcrystalline cellulose and glycerol in proportion;
s103, cleaning and drying the weighed radix angelicae, pepper, borneol, asarum, gallnut, cortex lycii radicis, rhizoma cimicifugae and mint, and adding 500 ml of clear water to decoct for 1 hour;
s104, adding 1000 ml of clear water and the capsule glue solution again, decocting for 2 to 3 hours, filtering out medicine residues, and naturally cooling the medicine solution in a container to obtain a paste; subpackaging the paste into dough, sterilizing, and packaging.
As shown in fig. 2, the purifying the obtained glycerin raw material provided in the embodiment of the present invention to obtain purified glycerin includes:
s201, mixing a glycerol raw material with a diluent to obtain diluted glycerol, and adjusting the pH value of the diluted glycerol by using an acid-base regulator;
s202, standing and layering the glycerol with the adjusted pH value to obtain a primarily filtered glycerol product; heating and stirring the primarily filtered glycerol product, and removing the upper layer to obtain a secondarily filtered glycerol product;
s203, separating the glycerol product subjected to secondary filtration by using a liquefaction chromatograph, and collecting the glycerol elution component; and (3) recovering the solvent from the collected glycerin elution component by low-temperature reduced pressure distillation to obtain the high-purity glycerin.
The acid-base regulator provided by the embodiment of the invention can be dilute acid solution or carbon dioxide.
As shown in fig. 3, the preparation of microcrystalline cellulose according to the embodiment of the present invention includes:
s301, heating a hydrochloric acid solution to 45 ℃, adding bleached wood pulp into the heated hydrochloric acid solution while stirring, and carrying out heat preservation reaction for a period of time;
s302, adding pre-dissolved cellulase into the reactant, and hydrolyzing for 1 hour at 70-90 ℃; obtaining mixed slurry;
s303, ultrasonically crushing, rinsing and drying the mixed glue stock to obtain a microcrystalline cellulose solid; and washing the microcrystalline cellulose solid by using triple distilled water, and drying at 60 ℃ to obtain the microcrystalline cellulose.
The technical solution of the present invention is further described below with reference to specific examples.
Aiming at gingivitis and the like, the prescription is that dahurian angelica root, pricklyash peel, borneol, asarum, gallnut, cortex lycii radicis, largetrifolioliolious bugbane rhizome, mint and other ingredients, such as microcrystalline cellulose, capsule glue solution and the like are adopted, after the medicinal ingredients are combined, the medicament is mashed into a paste, kneaded into small pieces and the like with proper shapes, and the small pieces are inserted into the slits between the diseased teeth, or attached to the diseased gums, or inserted onto the diseased teeth (decayed teeth).
The function is as follows: the disinfectant can stay at the affected part, so that the medicine gradually permeates into the focus, and the cement is easy to stick to the affected part, is not easy to dissolve and fall off and can be kept for several hours, so that the affected and inflamed place can be improved as soon as possible.
The above description is only for the purpose of illustrating the present invention and the appended claims are not to be construed as limiting the scope of the invention, which is intended to cover all modifications, equivalents and improvements that are within the spirit and scope of the invention as defined by the appended claims.
Claims (10)
1. The pharmaceutical composition for treating dental diseases is characterized by comprising 25-30 parts by mass of radix angelicae, 10-15 parts by mass of pepper, 20-25 parts by mass of borneol, 10-15 parts by mass of asarum, 10-15 parts by mass of gallnut, 5-8 parts by mass of cortex lycii radicis, 5-8 parts by mass of cimicifugae foetidae, 5-8 parts by mass of mint and 1-5 parts by mass of other ingredients;
the other types of ingredients include microcrystalline cellulose and glycerin.
2. A method for preparing the pharmaceutical composition for treating dental diseases according to claim 1, wherein the method for preparing the pharmaceutical composition for treating dental diseases comprises the steps of:
step one, obtaining a glycerol raw material, and purifying the obtained glycerol raw material to obtain purified glycerol; simultaneously preparing microcrystalline cellulose;
weighing radix angelicae, pepper, borneol, asarum, gallnut, cortex lycii radicis, cimicifugae foetidae, mint, microcrystalline cellulose and glycerol in proportion;
step three, cleaning and drying the weighed angelica dahurica, pepper, borneol, asarum, gallnut, cortex lycii radicis, cimicifugae foetidae and mint, and adding 500 ml of clear water to decoct for 1 hour;
step four, adding 1000 ml of clear water and the capsule glue solution again, decocting for 2 to 3 hours, filtering out medicine residues, and putting the medicine solution into a container for natural cooling to obtain a paste; subpackaging the paste into dough, sterilizing, and packaging.
3. The method of claim 2, wherein the step of purifying the glycerol source obtained in step one comprises:
mixing a glycerol raw material with a diluent to obtain diluted glycerol, and adjusting the pH value of the diluted glycerol by using an acid-base regulator;
standing and layering the glycerol after the pH value is adjusted to obtain a primarily filtered glycerol product; heating and stirring the primarily filtered glycerol product, and removing the upper layer to obtain a secondarily filtered glycerol product;
separating the glycerol product after the secondary filtration by using a liquefaction chromatogram, and collecting the eluted components of the glycerol; and (3) recovering the solvent from the collected glycerin elution component by low-temperature reduced pressure distillation to obtain the high-purity glycerin.
4. The method of claim 3, wherein the pH modifying agent is a dilute acid solution or carbon dioxide.
5. The method of preparing a pharmaceutical composition for treating dental diseases according to claim 2, wherein the step two, the preparing of the microcrystalline cellulose comprises:
(1) heating the hydrochloric acid solution to 45 ℃, adding bleached wood pulp into the heated hydrochloric acid solution while stirring, and carrying out heat preservation reaction for a period of time;
(2) adding pre-dissolved cellulase into the reactant, and hydrolyzing for 1 hour at 70-90 ℃; obtaining mixed slurry;
(3) ultrasonically crushing, rinsing and drying the mixed sizing material to obtain a microcrystalline cellulose solid; and washing the microcrystalline cellulose solid by using triple distilled water, and drying to obtain the microcrystalline cellulose.
6. The method of preparing a pharmaceutical composition for treating dental conditions of claim 5 wherein said oven drying comprises: drying at 60 deg.C.
7. Use of a pharmaceutical composition according to claim 1 for treating dental disorders in the manufacture of a medicament for treating or ameliorating dental disorders.
8. Use of a pharmaceutical composition according to claim 1 for the treatment of dental disorders in the manufacture of a daily care product for the prevention of dental disorders.
9. The use of any one of claims 7 to 8, wherein the dental condition comprises caries, pulpitis, periodontitis, periapicalitis and gingivitis.
10. The application of any of claims 7-8, wherein the application further comprises:
the pharmaceutical composition for treating dental diseases is cut into a proper shape and directly applied to diseased gingiva, or applied to diseased teeth, or applied to diseased slits between teeth.
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