CN105998528A - Dental care tooth brushing powder - Google Patents
Dental care tooth brushing powder Download PDFInfo
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- CN105998528A CN105998528A CN201610486590.2A CN201610486590A CN105998528A CN 105998528 A CN105998528 A CN 105998528A CN 201610486590 A CN201610486590 A CN 201610486590A CN 105998528 A CN105998528 A CN 105998528A
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- 239000000843 powder Substances 0.000 title claims abstract description 28
- 230000001680 brushing effect Effects 0.000 title claims abstract description 16
- 239000003814 drug Substances 0.000 claims abstract description 26
- 241000222336 Ganoderma Species 0.000 claims abstract description 14
- 229920002101 Chitin Polymers 0.000 claims abstract description 9
- 235000003470 Ilex asprella Nutrition 0.000 claims abstract description 9
- 241001100541 Ilex asprella Species 0.000 claims abstract description 9
- 240000003296 Petasites japonicus Species 0.000 claims abstract description 9
- 241000196324 Embryophyta Species 0.000 claims description 30
- 239000000551 dentifrice Substances 0.000 claims description 26
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 25
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 12
- 238000002137 ultrasound extraction Methods 0.000 claims description 12
- 239000002994 raw material Substances 0.000 claims description 10
- 239000007788 liquid Substances 0.000 claims description 9
- 239000005418 vegetable material Substances 0.000 claims description 9
- OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 claims description 8
- 244000307697 Agrimonia eupatoria Species 0.000 claims description 8
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 8
- GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 claims description 8
- 235000003823 Petasites japonicus Nutrition 0.000 claims description 8
- 241001169860 Sabia schumanniana Species 0.000 claims description 8
- 235000000125 common agrimony Nutrition 0.000 claims description 8
- 239000012153 distilled water Substances 0.000 claims description 7
- 230000001476 alcoholic effect Effects 0.000 claims description 6
- 238000001556 precipitation Methods 0.000 claims description 6
- 239000000203 mixture Substances 0.000 claims description 4
- 108010059892 Cellulase Proteins 0.000 claims description 3
- 229940106157 cellulase Drugs 0.000 claims description 3
- 238000004108 freeze drying Methods 0.000 claims description 3
- 238000004806 packaging method and process Methods 0.000 claims description 3
- 238000002360 preparation method Methods 0.000 claims description 3
- 238000010298 pulverizing process Methods 0.000 claims description 3
- 230000001954 sterilising effect Effects 0.000 claims description 3
- 238000004659 sterilization and disinfection Methods 0.000 claims description 3
- 238000003756 stirring Methods 0.000 claims description 3
- 229940034610 toothpaste Drugs 0.000 claims description 3
- 239000000606 toothpaste Substances 0.000 claims description 3
- 238000010792 warming Methods 0.000 claims description 3
- 238000000034 method Methods 0.000 claims 1
- 210000000515 tooth Anatomy 0.000 abstract description 25
- 230000000694 effects Effects 0.000 abstract description 10
- 208000002064 Dental Plaque Diseases 0.000 abstract description 2
- 206010061218 Inflammation Diseases 0.000 abstract description 2
- 229920002678 cellulose Polymers 0.000 abstract description 2
- 239000001913 cellulose Substances 0.000 abstract description 2
- 201000010099 disease Diseases 0.000 abstract description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract description 2
- 230000036039 immunity Effects 0.000 abstract description 2
- 150000004676 glycans Chemical class 0.000 abstract 2
- 229920001282 polysaccharide Polymers 0.000 abstract 2
- 239000005017 polysaccharide Substances 0.000 abstract 2
- 230000035943 smell Effects 0.000 abstract 2
- 241001278836 Agrimonia pilosa Species 0.000 abstract 1
- 235000000641 Agrimonia pilosa Nutrition 0.000 abstract 1
- 241000894006 Bacteria Species 0.000 abstract 1
- 240000003690 Callicarpa japonica Species 0.000 abstract 1
- 229920000742 Cotton Polymers 0.000 abstract 1
- 240000005717 Dioscorea alata Species 0.000 abstract 1
- 244000299507 Gossypium hirsutum Species 0.000 abstract 1
- 235000015456 Japanese beauty berry Nutrition 0.000 abstract 1
- 241000736246 Pyrola Species 0.000 abstract 1
- 235000001537 Ribes X gardonianum Nutrition 0.000 abstract 1
- 235000001535 Ribes X utile Nutrition 0.000 abstract 1
- 235000016919 Ribes petraeum Nutrition 0.000 abstract 1
- 244000281247 Ribes rubrum Species 0.000 abstract 1
- 235000002355 Ribes spicatum Nutrition 0.000 abstract 1
- 244000061458 Solanum melongena Species 0.000 abstract 1
- 235000002597 Solanum melongena Nutrition 0.000 abstract 1
- 241000205578 Thalictrum Species 0.000 abstract 1
- 235000008216 herbs Nutrition 0.000 abstract 1
- 230000004054 inflammatory process Effects 0.000 abstract 1
- 239000000845 maltitol Substances 0.000 abstract 1
- VQHSOMBJVWLPSR-WUJBLJFYSA-N maltitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O VQHSOMBJVWLPSR-WUJBLJFYSA-N 0.000 abstract 1
- 229940035436 maltitol Drugs 0.000 abstract 1
- 235000010449 maltitol Nutrition 0.000 abstract 1
- 208000028169 periodontal disease Diseases 0.000 abstract 1
- 235000019605 sweet taste sensations Nutrition 0.000 abstract 1
- 231100000331 toxic Toxicity 0.000 abstract 1
- 230000002588 toxic effect Effects 0.000 abstract 1
- 230000000052 comparative effect Effects 0.000 description 12
- 210000000214 mouth Anatomy 0.000 description 9
- 206010006326 Breath odour Diseases 0.000 description 4
- 208000032139 Halitosis Diseases 0.000 description 4
- 230000001408 fungistatic effect Effects 0.000 description 4
- 230000002159 abnormal effect Effects 0.000 description 3
- 230000000844 anti-bacterial effect Effects 0.000 description 3
- 208000002925 dental caries Diseases 0.000 description 3
- 238000000605 extraction Methods 0.000 description 3
- 239000000796 flavoring agent Substances 0.000 description 3
- 235000019634 flavors Nutrition 0.000 description 3
- 208000007565 gingivitis Diseases 0.000 description 3
- 201000001245 periodontitis Diseases 0.000 description 3
- 241000191940 Staphylococcus Species 0.000 description 2
- 241000194017 Streptococcus Species 0.000 description 2
- 241000194024 Streptococcus salivarius Species 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 230000005764 inhibitory process Effects 0.000 description 2
- 231100000252 nontoxic Toxicity 0.000 description 2
- 230000003000 nontoxic effect Effects 0.000 description 2
- 208000017667 Chronic Disease Diseases 0.000 description 1
- 230000000675 anti-caries Effects 0.000 description 1
- 230000003385 bacteriostatic effect Effects 0.000 description 1
- 229940126678 chinese medicines Drugs 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000003748 differential diagnosis Methods 0.000 description 1
- 238000007865 diluting Methods 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 235000021289 health related food Nutrition 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 231100000957 no side effect Toxicity 0.000 description 1
- 230000003239 periodontal effect Effects 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 230000033764 rhythmic process Effects 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
Classifications
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7032—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a polyol, i.e. compounds having two or more free or esterified hydroxy groups, including the hydroxy group involved in the glycosidic linkage, e.g. monoglucosyldiacylglycerides, lactobionic acid, gangliosides
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
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Abstract
The invention discloses a dental care tooth brushing powder. The dental care tooth brushing powder is prepared from eggplant roots, pyrola corbieri, cotton roots, roots or leaves of Ilex asprella (Hook. et Arn.) Champ. ex Benth., folium hibisci, airpotato yam rhizomes, all-grass of Agrimonia pilosa Ldb., rhizomes of Japanese Butterbur, radix tetrastigme, radix rubi parvifolii, henry currant roots, meadowrue roots and rhizomes, Japanese beauty-berry, nidus vespae, maltitol, ganoderma polysaccharide and chitin. The dental care tooth brushing powder contains rich cellulose and is fast in treatment effect, and the effective rate reaches up to 100%; ganoderma polysaccharide is naturally extracted and is safe, healthy and free of toxic and side effects, and the extracting rate reaches up to 26.7%; all the Chinese herbs are extracted and purified multiple times, and the yield is increased by 15.6%; the dental care tooth brushing powder has a faint scent and slight sweet taste, is easy to use, and can eliminate peculiar oral smells, fight bacteria and diminish inflammation, suppress dental plaques, prevent decayed teeth, whiten teethes, relieve periodontal diseases, prevent hemodia, relieve gomphiasis and falling, enhance the body immunity and prevent other diseases, a patient does not have the repugnance as no peculiar traditional Chinese medicine smell exists, and dental care can be carried out while the teeth are brushed.
Description
Technical field
The invention mainly relates to pharmaceutical technology field, particularly relate to a kind of oral health-care brush dentifrice.
Background technology
Along with gradually stepping up of people's living standard, begin to focus on various health promoting product, the most health-related food and apparatus, but, few people pay close attention to the health care to oral cavity.Ignoring oral cavity health, can produce multiple oral cavity chronic disease, such as halitosis, dental caries, gingivitis and periodontitis etc., resulting even in tooth comes off in advance, brings the biggest puzzlement to life.
Brush teeth is must doing one's homework of we every day, in the epoch that rhythm of life is gradually accelerated, in order to save the time of people, oral cavity health and brushing teeth is carried out simultaneously, therefore, the present invention provides a kind of oral health-care brush dentifrice, uses, save time while brushing teeth, laborsaving, effect is obvious, cheap.
Summary of the invention
In order to make up the defect of prior art, it is an object of the invention to provide a kind of oral health-care brush dentifrice.
A kind of oral health-care brush dentifrice, is made up of the raw material of following weight portion: Radix Solani Melongenae 17 ~ 19, Herba pyrolae japonicae 16 ~ 18, Radix Gossypii 15 ~ 17, Ilex asprella (Hook. et Arn.) Champ. ex Benth. 13 ~ 15, Folium Hibisci Mutabilis 12 ~ 14, Rhizoma Dioscoreae Bulbiferae 12 ~ 14, Agrimony 11 ~ 13, Petasites japonicus 11 ~ 13, Radix Apioris Fortunei (Radix Lespedezae Buergeri) 10 ~ 12, ull up field 10 ~ 12, Sabia schumanniana Diels 9 ~ 11, Radix et Rhizoma Thalictri root 9 ~ 11, Folium Callicarpae Formosanae 9 ~ 11, Nidus Vespae 8 ~ 10, maltose alcohol 7 ~ 9, ganoderan 0.16 ~ 0.18, chitin 0.11 ~ 0.13.
Preferably, described oral health-care brush dentifrice, is made up of the raw material of following weight portion: Radix Solani Melongenae 19, Herba pyrolae japonicae 18, Radix Gossypii 17, Ilex asprella (Hook. et Arn.) Champ. ex Benth. 15, Folium Hibisci Mutabilis 14, Rhizoma Dioscoreae Bulbiferae 14, Agrimony 13, Petasites japonicus 13, Radix Apioris Fortunei (Radix Lespedezae Buergeri) 12, ull up field 12, Sabia schumanniana Diels 11, Radix et Rhizoma Thalictri root 11, Folium Callicarpae Formosanae 11, Nidus Vespae 10, maltose alcohol 9, ganoderan 0.16, chitin 0.11.
nullDescribed ganoderan，Ganoderma sporophore is pulverized，Cross 80 ~ 100 mesh sieves，Obtain Ganoderma powder，Add the cellulase of Ganoderma powder weight 0.6 ~ 0.8%，41 ~ 43 DEG C of water-baths，56 ~ 58 revs/min are stirred enzymolysis 180 ~ 200 minutes，Take out，Add the water of Ganoderma powder weight 2 ~ 3 times amount，It is placed in 66 ~ 68 DEG C，The ultrasonic extraction of 28 ~ 30kHz 35 ~ 40 minutes，Repeat to extract 3 times，6000 revs/min are centrifuged 15 minutes，Abandon precipitation，Merge all lixiviating solution，Dry to the 1/5 of original volume for 70 ~ 72 DEG C，Adding volume fraction is the alcoholic solution of 65 ~ 67%，PH is adjusted to be 4.4 ~ 4.6 with the acetum that volume fraction is 6 ~ 8%，Accelerate to precipitate completely，Stir，It is placed in 3 ~ 5 DEG C，Stand 22 ~ 24 hours，8000 revs/min are centrifuged 15 minutes，Take precipitation，Being washed to pH is 6.4 ~ 7.2，Safety non-toxic，Extraction ratio is high，-44 ~-42 DEG C of lyophilizations are to without moisture，Obtain ganoderan.
A kind of preparation method of oral health-care brush dentifrice, its concrete steps include:
(1) Nidus Vespae is placed in container, in container, adds the water of Nidus Vespae weight 2 ~ 3 times amount, be warming up to 92 ~ 94 DEG C with 1.5 ~ 2.5 DEG C/min, be incubated 3 ~ 4 hours, go to eliminate the unusual smell, cross 140 ~ 160 mesh sieves, obtain Nidus Vespae lixiviating solution；
(2) by Radix Solani Melongenae, Herba pyrolae japonicae, Radix Gossypii, Ilex asprella (Hook. et Arn.) Champ. ex Benth., Folium Hibisci Mutabilis, Rhizoma Dioscoreae Bulbiferae, Agrimony, Petasites japonicus, Radix Apioris Fortunei (Radix Lespedezae Buergeri), ull up field, Sabia schumanniana Diels, Radix et Rhizoma Thalictri root and Folium Callicarpae Formosanae pulverizing, cross 120 ~ 140 mesh sieves, obtain vegetable material powder；
null(3) in vegetable material powder, add the distilled water of vegetable material grain weight amount 3 ~ 4 times amount，It is placed in 80 ~ 85 DEG C of water-baths，The ultrasonic extraction of 26 ~ 28kHz 35 ~ 40 minutes，5000 revs/min are centrifuged 10 minutes，Obtain extracting solution A and plant medicine dregs A，The distilled water of plant medicine dregs A weight 2 ~ 3 times amount is added in plant medicine dregs A，The ultrasonic extraction of 32 ~ 34kHz 25 ~ 30 minutes，6000 revs/min are centrifuged 10 minutes，Obtain extracting solution B and plant medicine dregs B，The alcoholic solution that volume fraction is 71 ~ 73% of plant medicine dregs B weight 2 ~ 3 times amount is added in plant medicine dregs B，Airtight，63 ~ 65 DEG C of water-baths，The ultrasonic extraction of 28 ~ 30kHz 30 ~ 35 minutes，8000 revs/min are centrifuged 10 minutes，All extracting solution and plant medicine dregs are mixed，It is placed in 75 ~ 80 DEG C of baking ovens，It is concentrated into the 1/3 of original volume，Obtain plant treatment liquid；
(4) in plant treatment liquid, add plant treatment liquid and amass the ether of 1/5 amount, 48 ~ 50 revs/min shake 40 ~ 50 minutes, stand 20 ~ 30 minutes, remove ether layer, obtain water layer extracting solution, water layer extracting solution is added in the bag filter that molecular weight is 32kD, flowing water is dialysed 22 ~ 24 hours, take out, add maltose alcohol, ganoderan, chitin and Nidus Vespae lixiviating solution, remove Chinese medicine abnormal flavour, mix homogeneously, in 46 ~ 48 DEG C of be concentrated in vacuo to that water content is all raw material weights 6 ~ 8%, cross 120 ~ 140 mesh sieves, obtain oral health-care brush dentifrice；
(5) packaging, in 40 ~ 42 DEG C, 119 ~ 121MPa ultrahigh-pressure sterilization 20 ~ 25 minutes, obtains finished product.
Described oral health-care brush dentifrice, when sooner or later brushing teeth, squeezes into toothpaste on toothbrush, then dips appropriate dentifrice, carry out brushing teeth.
The invention have the advantage that a kind of oral health-care brush dentifrice that the present invention provides, abundant raw material, rich cellulose, curative effect is quick, and effective percentage is up to 100%；Raw material is easy to get, cheap, alleviates the financial burden of patient；Ganoderan extracts through pure natural, and safety and Health has no side effect, and extraction ratio is up to 26.7%, increases operation rate；All Chinese medicines are through repeatedly extracting and purification, and yield improves 15.6%, saves a large amount of production cost；Fragrant in taste is light sweet, and without Chinese medicine abnormal flavour, patient does not have conflict sense, use simple, oral cavity health when brushing teeth, can be carried out, it is possible to eliminate halitosis, cleaning tooth, anti-inflammation, suppresses dental plaque, pre-anti-caries, tooth-whitening, alleviate periodontal, prevent hemodia, alleviate odontoseisis to come off, enhancing human body immunity power, it is to avoid cause the generation of Other diseases.
Detailed description of the invention
With specific embodiment, the present invention is described below.
Embodiment
A kind of oral health-care brush dentifrice, is made up of the raw material of following weight portion: Radix Solani Melongenae 19, Herba pyrolae japonicae 18, Radix Gossypii 17, Ilex asprella (Hook. et Arn.) Champ. ex Benth. 15, Folium Hibisci Mutabilis 14, Rhizoma Dioscoreae Bulbiferae 14, Agrimony 13, Petasites japonicus 13, Radix Apioris Fortunei (Radix Lespedezae Buergeri) 12, ull up field 12, Sabia schumanniana Diels 11, Radix et Rhizoma Thalictri root 11, Folium Callicarpae Formosanae 11, Nidus Vespae 10, maltose alcohol 9, ganoderan 0.16, chitin 0.11.
nullDescribed ganoderan，Ganoderma sporophore is pulverized，Cross 100 mesh sieves，Obtain Ganoderma powder，Add the cellulase of Ganoderma powder weight 0.6%，41 DEG C of water-baths，56 revs/min are stirred enzymolysis 180 minutes，Take out，Add the water of Ganoderma powder weight 2 times amount，It is placed in 66 DEG C，The ultrasonic extraction of 28kHz 40 minutes，Repeat to extract 3 times，6000 revs/min are centrifuged 15 minutes，Abandon precipitation，Merge all lixiviating solution，Dry to the 1/5 of original volume for 70 DEG C，Adding volume fraction is the alcoholic solution of 67%，PH is adjusted to be 4.6 with the acetum that volume fraction is 6%，Accelerate to precipitate completely，Stir，It is placed in 5 DEG C，Stand 24 hours，8000 revs/min are centrifuged 15 minutes，Take precipitation，Being washed to pH is 6.8，Safety non-toxic，Extraction ratio is high，-42 DEG C of lyophilizations are to without moisture，Obtain ganoderan.
A kind of preparation method of oral health-care brush dentifrice, its concrete steps include:
(1) Nidus Vespae is placed in container, in container, adds the water of Nidus Vespae weight 3 times amount, be warming up to 92 DEG C with 2 DEG C/min, be incubated 4 hours, go to eliminate the unusual smell, cross 140 mesh sieves, obtain Nidus Vespae lixiviating solution；
(2) by Radix Solani Melongenae, Herba pyrolae japonicae, Radix Gossypii, Ilex asprella (Hook. et Arn.) Champ. ex Benth., Folium Hibisci Mutabilis, Rhizoma Dioscoreae Bulbiferae, Agrimony, Petasites japonicus, Radix Apioris Fortunei (Radix Lespedezae Buergeri), ull up field, Sabia schumanniana Diels, Radix et Rhizoma Thalictri root and Folium Callicarpae Formosanae pulverizing, cross 120 mesh sieves, obtain vegetable material powder；
(3) in vegetable material powder, add the distilled water of vegetable material grain weight amount 4 times amount, it is placed in 80 DEG C of water-baths, the ultrasonic extraction of 26kHz 40 minutes, 5000 revs/min are centrifuged 10 minutes, obtain extracting solution A and plant medicine dregs A, the distilled water of plant medicine dregs A weight 3 times amount is added in plant medicine dregs A, the ultrasonic extraction of 32kHz 30 minutes, 6000 revs/min are centrifuged 10 minutes, obtain extracting solution B and plant medicine dregs B, the alcoholic solution that volume fraction is 73% of plant medicine dregs B weight 2 times amount is added in plant medicine dregs B, airtight, 63 DEG C of water-baths, the ultrasonic extraction of 30kHz 30 minutes, 8000 revs/min are centrifuged 10 minutes, all extracting solution and plant medicine dregs are mixed, it is placed in 75 DEG C of baking ovens, it is concentrated into the 1/3 of original volume, obtain plant treatment liquid；
(4) adding plant treatment liquid in plant treatment liquid and amass the ether of 1/5 amount, 48 revs/min shake 50 minutes, stand 20 minutes, remove ether layer, obtain water layer extracting solution, water layer extracting solution is added in the bag filter that molecular weight is 32kD, flowing water is dialysed 24 hours, take out, add maltose alcohol, ganoderan, chitin and Nidus Vespae lixiviating solution, remove Chinese medicine abnormal flavour, mix homogeneously, in 46 DEG C of be concentrated in vacuo to that water content is all raw material weights 6%, cross 120 mesh sieves, obtain oral health-care brush dentifrice；
(5) packaging, in 40 DEG C, 119MPa ultrahigh-pressure sterilization 25 minutes, obtains finished product.
Comparative example
Commercially available powder of commonly brushing teeth.
Embodiment and comparative example are brushed teeth the fungistatic effect of powder:
Example and the powder 100 of brushing teeth of comparative example respectively, add the distilled water diluting of equivalent, mix homogeneously, add in the culture dish of staphylococcus, facultative diphtheroid, blood group streptococcus and streptococcus salivarius, carry out bacteriostatic test, cultivate 12 ~ 14 hours, utilize the brush teeth fungistatic effect of powder of the diameter of vernier caliper measurement inhibition zone, embodiment and comparative example to be shown in Table 1.
Table 1: embodiment and comparative example are brushed teeth the fungistatic effect of powder
As can be seen from Table 1, the oral health-care brush dentifrice of embodiment, act on staphylococcus, facultative diphtheroid, blood group streptococcus and streptococcus salivarius, each antibacterial antibacterial circle diameter of embodiment is all significantly greater than comparative example, the inhibition of antibacterial is substantially better than comparative example, illustrates that embodiment oral health-care brush dentifrice has obvious fungistatic effect.
Embodiment and comparative example are brushed teeth the mouth care effect of powder:
Usage and dosage: when sooner or later brushing teeth, squeeze into toothpaste, then dip appropriate dentifrice, carry out brushing teeth on toothbrush, uses 60 days continuously.
Curative effect determinate standard:
Effective: halitosis, xanthodont, dental caries, gingivitis, periodontitis, odontoseisis symptom alleviate, and have taken a turn for the better；
Cure: halitosis, xanthodont, dental caries, gingivitis, periodontitis, odontoseisis transference cure.
Test case:
Randomly choosing patient 200 example, the standard of selection is: meet Western medicine diagnose standard and differential diagnosis in tcm standard, age between 18 ~ 55 years old.At random above-mentioned case being divided into embodiment group and comparative example group, each 100 people, men and women half and half, and the brush teeth mouth care effect of powder of embodiment and comparative example is shown in Table 2.
Table 2: embodiment and comparative example are brushed teeth the mouth care effect of powder
From table 2 it can be seen that the oral health-care brush dentifrice of embodiment, effective percentage is 100%, and cure rate is obviously higher than comparative example group, and effect is lasting, illustrates that embodiment oral health-care brush dentifrice has preferable mouth care effect.
Claims (5)
1. an oral health-care brush dentifrice, it is characterized in that, be made up of the raw material of following weight portion: Radix Solani Melongenae 17 ~ 19, Herba pyrolae japonicae 16 ~ 18, Radix Gossypii 15 ~ 17, Ilex asprella (Hook. et Arn.) Champ. ex Benth. 13 ~ 15, Folium Hibisci Mutabilis 12 ~ 14, Rhizoma Dioscoreae Bulbiferae 12 ~ 14, Agrimony 11 ~ 13, Petasites japonicus 11 ~ 13, Radix Apioris Fortunei (Radix Lespedezae Buergeri) 10 ~ 12, ull up field 10 ~ 12, Sabia schumanniana Diels 9 ~ 11, Radix et Rhizoma Thalictri root 9 ~ 11, Folium Callicarpae Formosanae 9 ~ 11, Nidus Vespae 8 ~ 10, maltose alcohol 7 ~ 9, ganoderan 0.16 ~ 0.18, chitin 0.11 ~ 0.13.
Oral health-care brush dentifrice the most according to claim 1, it is characterized in that, be made up of the raw material of following weight portion: Radix Solani Melongenae 19, Herba pyrolae japonicae 18, Radix Gossypii 17, Ilex asprella (Hook. et Arn.) Champ. ex Benth. 15, Folium Hibisci Mutabilis 14, Rhizoma Dioscoreae Bulbiferae 14, Agrimony 13, Petasites japonicus 13, Radix Apioris Fortunei (Radix Lespedezae Buergeri) 12, ull up field 12, Sabia schumanniana Diels 11, Radix et Rhizoma Thalictri root 11, Folium Callicarpae Formosanae 11, Nidus Vespae 10, maltose alcohol 9, ganoderan 0.16, chitin 0.11.
nullOral health-care brush dentifrice the most according to claim 1，It is characterized in that，Described ganoderan，Ganoderma sporophore is pulverized，Cross 80 ~ 100 mesh sieves，Obtain Ganoderma powder，Add the cellulase of Ganoderma powder weight 0.6 ~ 0.8%，41 ~ 43 DEG C of water-baths，56 ~ 58 revs/min are stirred enzymolysis 180 ~ 200 minutes，Take out，Add the water of Ganoderma powder weight 2 ~ 3 times amount，It is placed in 66 ~ 68 DEG C，The ultrasonic extraction of 28 ~ 30kHz 35 ~ 40 minutes，Repeat to extract 3 times，6000 revs/min are centrifuged 15 minutes，Abandon precipitation，Merge all lixiviating solution，Dry to the 1/5 of original volume for 70 ~ 72 DEG C，Adding volume fraction is the alcoholic solution of 65 ~ 67%，PH is adjusted to be 4.4 ~ 4.6 with the acetum that volume fraction is 6 ~ 8%，Accelerate to precipitate completely，Stir，It is placed in 3 ~ 5 DEG C，Stand 22 ~ 24 hours，8000 revs/min are centrifuged 15 minutes，Take precipitation，Being washed to pH is 6.4 ~ 7.2，-44 ~-42 DEG C of lyophilizations are to without moisture，Obtain ganoderan.
The preparation method of oral health-care brush dentifrice the most according to claim 1, it is characterised in that comprise the following steps:
(1) Nidus Vespae is placed in container, in container, adds the water of Nidus Vespae weight 2 ~ 3 times amount, be warming up to 92 ~ 94 DEG C with 1.5 ~ 2.5 DEG C/min, be incubated 3 ~ 4 hours, cross 140 ~ 160 mesh sieves, obtain Nidus Vespae lixiviating solution；
(2) by Radix Solani Melongenae, Herba pyrolae japonicae, Radix Gossypii, Ilex asprella (Hook. et Arn.) Champ. ex Benth., Folium Hibisci Mutabilis, Rhizoma Dioscoreae Bulbiferae, Agrimony, Petasites japonicus, Radix Apioris Fortunei (Radix Lespedezae Buergeri), ull up field, Sabia schumanniana Diels, Radix et Rhizoma Thalictri root and Folium Callicarpae Formosanae pulverizing, cross 120 ~ 140 mesh sieves, obtain vegetable material powder；
null(3) in vegetable material powder, add the distilled water of vegetable material grain weight amount 3 ~ 4 times amount，It is placed in 80 ~ 85 DEG C of water-baths，The ultrasonic extraction of 26 ~ 28kHz 35 ~ 40 minutes，5000 revs/min are centrifuged 10 minutes，Obtain extracting solution A and plant medicine dregs A，The distilled water of plant medicine dregs A weight 2 ~ 3 times amount is added in plant medicine dregs A，The ultrasonic extraction of 32 ~ 34kHz 25 ~ 30 minutes，6000 revs/min are centrifuged 10 minutes，Obtain extracting solution B and plant medicine dregs B，The alcoholic solution that volume fraction is 71 ~ 73% of plant medicine dregs B weight 2 ~ 3 times amount is added in plant medicine dregs B，Airtight，63 ~ 65 DEG C of water-baths，The ultrasonic extraction of 28 ~ 30kHz 30 ~ 35 minutes，8000 revs/min are centrifuged 10 minutes，All extracting solution and plant medicine dregs are mixed，It is placed in 75 ~ 80 DEG C of baking ovens，It is concentrated into the 1/3 of original volume，Obtain plant treatment liquid；
(4) in plant treatment liquid, add plant treatment liquid and amass the ether of 1/5 amount, 48 ~ 50 revs/min shake 40 ~ 50 minutes, stand 20 ~ 30 minutes, remove ether layer, obtain water layer extracting solution, water layer extracting solution is added in the bag filter that molecular weight is 32kD, flowing water is dialysed 22 ~ 24 hours, take out, adding maltose alcohol, ganoderan, chitin and Nidus Vespae lixiviating solution, mix homogeneously, in 46 ~ 48 DEG C of be concentrated in vacuo to that water content is all raw material weights 6 ~ 8%, cross 120 ~ 140 mesh sieves, obtain oral health-care brush dentifrice；
(5) packaging, in 40 ~ 42 DEG C, 119 ~ 121MPa ultrahigh-pressure sterilization 20 ~ 25 minutes, obtains finished product.
5. according to the using method of oral health-care brush dentifrice described in claim 1 ~ 4, it is characterised in that when sooner or later brushing teeth, toothbrush is squeezed into toothpaste, then dips appropriate dentifrice, carry out brushing teeth.
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| CN201610486590.2A CN105998528A (en) | 2016-06-29 | 2016-06-29 | Dental care tooth brushing powder |
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| CN201610486590.2A CN105998528A (en) | 2016-06-29 | 2016-06-29 | Dental care tooth brushing powder |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107281047A (en) * | 2017-08-03 | 2017-10-24 | 何家平 | A kind of oral cavity anti-inflammatory Chinese traditional medicine tooth powder technique |
| CN110452313A (en) * | 2019-09-08 | 2019-11-15 | 淮安市厚沐医疗技术咨询中心 | A kind of refined plant polysaccharide, preparation method and the application in terms of preparing cosmetics |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1345595A (en) * | 2000-09-27 | 2002-04-24 | 张伟 | Aerosol for oral cavity health care |
| CN103040712A (en) * | 2012-12-26 | 2013-04-17 | 南京恒青楼宇设备有限公司青岛分公司 | Mouth wash |
| CN104127586A (en) * | 2014-08-13 | 2014-11-05 | 陈林旭 | Mouth wash capable of inhibiting gum bleeding and preparation method thereof |
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2016
- 2016-06-29 CN CN201610486590.2A patent/CN105998528A/en not_active Withdrawn
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1345595A (en) * | 2000-09-27 | 2002-04-24 | 张伟 | Aerosol for oral cavity health care |
| CN103040712A (en) * | 2012-12-26 | 2013-04-17 | 南京恒青楼宇设备有限公司青岛分公司 | Mouth wash |
| CN104127586A (en) * | 2014-08-13 | 2014-11-05 | 陈林旭 | Mouth wash capable of inhibiting gum bleeding and preparation method thereof |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107281047A (en) * | 2017-08-03 | 2017-10-24 | 何家平 | A kind of oral cavity anti-inflammatory Chinese traditional medicine tooth powder technique |
| CN110452313A (en) * | 2019-09-08 | 2019-11-15 | 淮安市厚沐医疗技术咨询中心 | A kind of refined plant polysaccharide, preparation method and the application in terms of preparing cosmetics |
| CN110452313B (en) * | 2019-09-08 | 2021-11-19 | 上海瞬锋化工科技有限公司 | Refined plant polysaccharide, preparation method and application in preparing cosmetics |
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