CN104127356A - Sea-buckthorn oropharynx antibacterial and antiphlogistic compositional liquid and preparation method thereof - Google Patents
Sea-buckthorn oropharynx antibacterial and antiphlogistic compositional liquid and preparation method thereof Download PDFInfo
- Publication number
- CN104127356A CN104127356A CN201410388109.7A CN201410388109A CN104127356A CN 104127356 A CN104127356 A CN 104127356A CN 201410388109 A CN201410388109 A CN 201410388109A CN 104127356 A CN104127356 A CN 104127356A
- Authority
- CN
- China
- Prior art keywords
- hippophae
- fructus hippophae
- oropharynx
- sea
- liquid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Abstract
The invention relates to a sea-buckthorn oropharynx antibacterial and antiphlogistic compositional liquid and a preparation method thereof. The compositional liquid is prepared from a sea-buckthorn leaf decoction liquid, a sea-buckthorn fruit refined substance, plant essential oil, a cosolvent and a sweetening agent via the steps of removing water of the sea-buckthorn leaf, decocting, cooling and filtering to prepare the decoction liquid, pulping fresh sea-buckthorn fruits, carrying out reflux extraction through an alcohol aqueous solution, removing the impurities such as sugar and tartaric acid in the fruits bad for the tooth health through macroporous resin, and compositing the sea-buckthorn leaf decoction liquid, the sea-buckthorn fruit refined substance, the plant essential oil, the cosolvent and the sweetening agent. The sea-buckthorn oropharynx antibacterial and antiphlogistic compositional liquid has the effects of resisting bacteria, diminishing inflammation, easing pain, stopping bleeding, eliminating phlegm and freshening breath when being applied to mouth and throat; the raw materials are food and drug plants which are low in cost, easy to get, free of artificial preservatives, free of toxic and side effects, unique in fragrance and convenient to use.
Description
Technical field
The present invention relates to a kind of Fructus Hippophae oropharynx anti-inflammation combination liquid and preparation method thereof.
Background technology
Along with living standards of the people and health perception improve, oral hygiene is subject to people's attention day by day, one of World Health Organization's ten large standards using oral health as health.Residue after feed in oral cavity can grow a lot of antibacterials, causes dental caries and halitosis, and when people's hormone in vivo is secreted not normal or hypoimmunity, antibacterial amount reproduction just can cause the diseases such as oral ulcer, periodontitis, tonsil inflammation and pharyngitis.The researcher of Univ Zurich Switzerland finds, common streptococcus S.tigurinus in oral cavity, and the blood capillary that the gingiva by inflammation enters periodontal tissue also can bring out cardiovascular disease.Therefore, for building clean healthy hygienic conditions in oral cavity, to healthy extremely important.Collutory and spray can go deep into oral cavity and throat depths, and cleaning effect is more thorough, and use convenient.
Fructus Hippophae is the huge industrial crops of a kind of potentiality to be exploited, and its fruit, leaf, root, seed all can be used as medicine.Eightth century of Christian era Tibetan medicine's book < < month king medicine is examined in > > and just the drug effect of Fructus Hippophae has been done to detailed record, it is the medical record of relevant Fructus Hippophae the earliest in the world, in China dimension doctor, Tibetan medicine and Mongolian medicine's traditional medicine, all with single Fructus Hippophae or compound treatment various diseases, within 1977, Ministry of Public Health is formally listed Fructus Hippophae in < < Chinese Pharmacopoeia > > first.
Fructus Hippophae is rich in the bioactive ingredients such as multivitamin, flavone, organic acid, terpenoid, sterol, carotenoid, unsaturated fatty acid, has fine exploitation be worth at cosmetics, health food and field of medicaments.< < China National medicine will > > describes the Uighurs and controls aphtha of the mouth and tongue and avitaminosis with Fructus Hippophae.In < < Uigurs medicine will > >, recording Fructus Hippophae has heat-clearing and toxic substances removing, detumescence blood stasis dispelling, the effect of pain relieving.In < < desert area medicinal plants > >, record juice of Fructus Hippophae sugaring, boiled water is taken after mixing it with water and is used for the treatment of laryngopharynx swelling and pain.Therefore Fructus Hippophae just has the effect for the treatment of oral ulcer and laryngopharynx swelling and pain in traditional Uygur medicine.The compositions such as the flavone in sea buckthorn fruit, phenolic acid have stronger bacteriostasis to gram positive bacteria pathogenic in oral cavity, can significantly lower the expression of the inflammation factor, promote macrophage phagocytic ability, the oxidative stress damage that its powerful antioxidation energy inflammation-inhibiting causes.In sea buckthorn fruit, contain abundant isorhamnetin, also there is the effect of relieving cough and asthma.
In Folium Hippophae, except containing the compositions such as abundant flavone, organic acid, also contain a large amount of tannins, can make gingival hemorrhage blood capillary shrink, there is local hemostatic effect.India scientist research shows that Folium Hippophae extract has very strong broad-spectrum antibacterial action, gram positive bacteria and gram negative bacteria are all had to remarkable bacteriostasis, and be stronger neuraminidase inhibitor, A type and Influenza B virus are all had to stronger antivirus action.
Through patent searching application number, be 200810002006.5, denomination of invention has for disclosing the preparation of employing hippophae plant extract in " containing the oral care composition of hippophae plant extract " oral tissue inflammation of alleviating, suppress gingivitis, reduce toothpaste, collutory and dental floss that dental plaque formed and kept or strengthened mammlian system health.What in this formula, use is the extract that Fructus Hippophae directly obtains via solvent extraction, and in ripe Fructus Hippophae, contains a large amount of sugars and fruit acid composition.Wherein carbohydrate content mainly comprises glucose, fructose and ethyl glucuronide etc.Fruit acid constituents mainly comprises malic acid, quinic acid, oxalic acid and citric acid etc., and its pulp pH can reach 2.3-3.2.Saccharide and fruit acid constituents are soluble in the conventional solvent that extracts such as ethanol, water, in leaching process, by further enrichment, make in extract content higher.Carbohydrate content is converted into acid under the effect of oral cavity streptococcus intermedius, make dental enamel surface demineralization, and then form decayed tooth, and fruit acid constituents directly causes corrosivity injury to tooth especially.This research adopts the method for macroporous resin further refining to Fructus Hippophae extracting solution, according to the difference of Van der Waals force, hydrogen bond and ion exchange between acids composition, carbohydrate content and active component and macroporous resin, sugar and fruit acid constituents are removed to the injury of avoiding its life-time service to cause tooth.
Summary of the invention
The object of the invention is, a kind of Fructus Hippophae oropharynx anti-inflammation combination liquid and preparation method thereof is provided, this Fructus Hippophae oropharynx anti-inflammation combination liquid is by Folium Hippophae decoction liquor, Fructus Hippophae is refined thing, plants essential oil, cosolvent and sweeting agent are made, employing decocts Folium Hippophae after completing, cooling, filtration makes decoction liquor, again by after fresh sea buckthorn fruit making beating, by ethanol water reflux, extract, by macroporous resin, remove and in fruit, be unfavorable for the impurity such as the sugar of dental health and fruit acid again, again by Folium Hippophae decoction liquor, Fructus Hippophae is refined thing, plants essential oil, sweeting agent % and cosolvent are formulated.Fructus Hippophae oropharynx anti-inflammation of the present invention combination liquid thering is antibacterial, antiinflammatory, analgesia for oral cavity and throat, stop blooding, eliminate the phlegm, the multiple efficacies such as fresh breath, raw materials used cheap and easy to get, for medicinal and edible plants, do not add artificial preservative's composition, have no side effect, fragrance is unique, easy to use.
A kind of Fructus Hippophae oropharynx anti-inflammation combination liquid of the present invention, each component of this combination liquid be take weight ratio as the refining thing 0-0.5% of Fructus Hippophae, plants essential oil is plant Herba Menthae, Fructus Cumini Cymini, Fructus Citri Limoniae, Flos Rosae Rugosae or the ginger essential oil 0.01-0.03% of edibility, sweeting agent is xylitol, sorbitol, stevioside or saccharin sodium 2-10%, cosolvent is glycerol or edible ethanol 3-15%, and Folium Hippophae decoction liquor 74.47-94.99% makes.
The preparation method of described Fructus Hippophae oropharynx anti-inflammation combination liquid, follows these steps to carry out:
A, fresh Folium Hippophae is clean, completes, and the pure water heating of doubly measuring with mass volume ratio 10-30 decocts, and extracts 1-4 time, and each 1-3 hour, merges, and cooling, filtration makes Folium Hippophae extracting solution;
B, fresh sea buckthorn fruit is clean, making beating, be that 30-70% alcohol heating reflux extracts by volumetric concentration, obtains extracting solution, then by extracting solution distilling under reduced pressure, reclaim ethanol, obtains Fructus Hippophae extracting solution;
Macroporous resin column on c, Fructus Hippophae extracting solution that step b is obtained, is that 0-10% ethanol rushes post by volumetric concentration, discards eluent, remove sugar and fruit acid, continuing is that 30-80% ethanol rushes post by concentration, eluent distilling under reduced pressure, reclaim ethanol, spraying is dry, obtains the refining thing of Fructus Hippophae;
D. to the Folium Hippophae extracting solution 74.47-94.99% that adds step a to obtain in material-compound tank, Fructus Hippophae is refined thing 0-0.5%, plants essential oil 0.01-0.03%, sweeting agent 2-10%, cosolvent is glycerol or edible ethanol 3-15%, stirs, centrifugal, get supernatant sterilization, fill, obtains Fructus Hippophae oropharynx anti-inflammation combination liquid.
In step c the macroporous resin that uses be polystyrene resin, polyacrylic acid resinoid or ion exchange resin, its model is AB-8, X-5, HPD-300, HPD-450, HPD-600 or HPD-700.
It is clean in preparation maintains oral cavity that described Fructus Hippophae oropharynx anti-inflammation combines liquid, and fresh breath suppresses oral cavity bacterium breeding, alleviates oral ulcer, suppresses oral inflammation, alleviates dental pain, the purposes in the medicine of alleviation gingival hemorrhage.
A kind of Fructus Hippophae oropharynx anti-inflammation combination liquid of the present invention, the refining thing of Fructus Hippophae in this combination liquid and flavone, phenolic acid, tannin and the alkaloids composition in Folium Hippophae extracting solution are main active component, be aided with plant-derived essential oil fragrance is provided, strengthen anti-microbial property, and there is antisepsis.The method of the invention be take Folium Hippophae extracting solution decoction liquor place of water as solvent has enriched the active component in formula with antibacterial and anti-inflammation functions, and resource is made full use of more.It is raw material that the method is utilized medicinal and edible plants resource Fructus Hippophae and Folium Hippophae, with reference to adopting the method for Fructus Hippophae treatment aphtha of the mouth and tongue in uighur ' s culture medicine ancient books and records, in conjunction with the Fructus Hippophae of finding in domestic and international Natural products research and nutritional labeling and the pharmacological action of Folium Hippophae, through the Fructus Hippophae oropharynx anti-inflammation combination liquid of science collocation and the processing of unique process for purification.
The present invention be take Folium Hippophae decoction liquor as solvent, has increased flavone in combination liquid, phenolic acid isoreactivity composition, and in Folium Hippophae, tannin constituents also has convergence gingiva wound, reduces the effect of gingival hemorrhage.Folium Hippophae is compared fruit, and resource is more cheap and easy to get, thereby sea buckthorn resources is utilized more fully.
The present invention is by processing that fresh Folium Hippophae is completed, can rapid damage and the fresh blade of passivation in polyphenol oxidase, avoid combining the enzymatic oxidation of liquid in preservation process.
The present invention is raw materials used cheap and easy to get, is medicinal and edible plants, does not add western medicine composition, and fragrance uniqueness has no side effect.
The present invention combines in liquid and contains a large amount of phenols components, should use the container filling of dark bottles or other minimizing irradiate light, should keep in Dark Place, to reduce light-catalysed oxidation reaction.
The major function factor that Fructus Hippophae oropharynx anti-inflammation combination liquid of the present invention comprises has:
Flavone: contain in Fructus Hippophae oropharynx anti-inflammation combination liquid and take in a large number the flavones ingredient that isorhamnetin and Quercetin be aglycon, there is the expression of inflammatory factor, the oxidative stress that inflammation-inhibiting causes and the effect that improves inflammation part vascular permeability of lowering, also have certain antibacterial ability and analgesic activity, isorhamnetin also has the effect of eliminating phlegm and stopping cough in addition.
Phenolic acid: the phenolic acid composition in Fructus Hippophae oropharynx anti-inflammation combination liquid comprises gallic acid, protocatechuic acid, caffeic acid, salicylic acid, cinnamic acid, ferulic acid, vanillic acid etc., there is very strong antibacterial activity and anti-oxidation stress ability, infected by influenza also has certain inhibition ability, and has stronger antiinflammatory action.
Tannin: contain a certain amount of tannin constituents in Fructus Hippophae oropharynx anti-inflammation combination liquid, can make gingival hemorrhage blood capillary shrink, there is local hemostatic effect.And there is broad-spectrum antiseptic ability and stronger antiinflammatory action.
Alkaloid: contain a certain amount of 5-hydroxy tryptamine and derivant thereof in Fructus Hippophae oropharynx anti-inflammation combination liquid, this constituents has certain analgesic activity.
Volatile oil: plants essential oil has the effect of antibacterial, analgesia, fresh breath.
Fructus Hippophae oropharynx anti-inflammation combination liquid of the present invention can be prepared into collutory or spray, but is not limited to this two kinds of forms, for keeping oral cavity cleaning, reduces the antibacterial infection of oral cavity and throat and the generation of inflammation.
The specific embodiment
Following examples are not limited only to the scope of the invention:
Embodiment 1
The preparation of Folium Hippophae decoction liquor:
Fresh Folium Hippophae is cleaned, added parch pot, 200 ℃ of high temperature complete fast, get the rear blade 1kg that completes, and use the heating of 10L pure water to decoct and extract 4 times, each 1 hour, merge, cooling, filtration makes Folium Hippophae extracting solution;
The refining thing preparation of Fructus Hippophae:
Fresh sea buckthorn fruit 1kg is cleaned, pulls an oar, by volumetric concentration, is that 60% alcohol heating reflux extracts, obtain extracting solution, then by extracting solution distilling under reduced pressure, reclaim ethanol, obtain Fructus Hippophae extracting solution;
By AB-8 macroporous adsorptive resins on Fructus Hippophae extracting solution, with volumetric concentration 10% ethanol, rush post, discard eluent, remove sugar and fruit acid, continue with volumetric concentration 50% ethanol, to rush post, eluent distilling under reduced pressure, reclaim ethanol, spraying is dry, obtains the refining thing 52g of Fructus Hippophae;
The collutory that preparation total amount is 10L:
By the refining thing 50g of Fructus Hippophae, cumin essential oil 3g, xylitol 1kg, glycerol 1L, Folium Hippophae decoction liquor 9L adds in material-compound tank, and stirring and dissolving is centrifugal, and by supernatant high-temperature sterilization, fill, obtains Fructus Hippophae anti-inflammation collutory.
Embodiment 2
The preparation of Folium Hippophae decoction liquor:
Fresh Folium Hippophae is cleaned, added green steaming chamber, steam high temperature completes fast, gets the rear blade 1kg that completes, and uses the heating of 30L pure water to decoct 3 hours, extracts 1-4 time, and each 1-3 hour, merges, and cooling, filtration makes Folium Hippophae extracting solution;
The refining thing preparation of Fructus Hippophae:
Fresh sea buckthorn fruit 1kg is cleaned, pulls an oar, by volumetric concentration, is that 30% alcohol heating reflux extracts, obtain extracting solution, then by extracting solution distilling under reduced pressure, reclaim ethanol, obtain Fructus Hippophae extracting solution;
By HPD-450 macroporous resin column on Fructus Hippophae extracting solution, with pure water, rush post, discard eluent, remove sugar and fruit acid, continuing is that 30% ethanol rushes post by concentration, and ethanol is reclaimed in eluent distilling under reduced pressure, and spraying is dry, obtains the refining thing 61g of Fructus Hippophae;
The collutory that preparation total amount is 10L:
By the refining thing 10g of Fructus Hippophae, Mentholum 2g, sorbitol 500g, edible ethanol 500mL, Folium Hippophae decoction liquor 9.5L adds in material-compound tank, and stirring and dissolving is centrifugal, gets supernatant sterilization, and fill, obtains Fructus Hippophae anti-inflammation collutory.
Embodiment 3
The preparation of Folium Hippophae decoction liquor:
Fresh Folium Hippophae is cleaned, added microwave deactivation of enzyme machine to complete fast, get the rear blade 1kg that completes, with the heating of 20L pure water, decoct 2 times, each 2 hours, make Folium Hippophae decoction liquor;
The throat spraying agent that preparation total amount is 10L:
By Flos Rosae Rugosae quintessence oil 1g, stevioside 200g, edible ethanol 300mL, Folium Hippophae decoction liquor 9.7L adds in material-compound tank, and stirring and dissolving is centrifugal, gets supernatant sterilization, and fill, obtains Fructus Hippophae anti-inflammation throat spraying agent.
Embodiment 4
The preparation of Folium Hippophae decoction liquor:
Fresh Folium Hippophae is clean, add green steaming chamber, steam high temperature completes fast, gets the rear blade 1kg that completes, and with the heating of 20L pure water, decocts, extract 1 time, 2 hours, merge, cooling, filtration makes Folium Hippophae extracting solution;
The refining thing preparation of Fructus Hippophae:
Fresh sea buckthorn fruit 1kg is cleaned, pulls an oar, by volumetric concentration, is that 70% alcohol heating reflux extracts, obtain extracting solution, then by extracting solution distilling under reduced pressure, reclaim ethanol, obtain Fructus Hippophae extracting solution;
By X-5 macroporous resin column on Fructus Hippophae extracting solution, by concentration, be that 5% ethanol rushes post, discard eluent, remove sugar and fruit acid, continuing is that 50% ethanol rushes post by concentration, and ethanol is reclaimed in eluent distilling under reduced pressure, and spraying is dry, obtains the refining thing 55g of Fructus Hippophae;
The collutory that preparation total amount is 10L:
By the refining thing 30g of Fructus Hippophae, ginger essential oil 3g, saccharin sodium 500g, edible ethanol 1.5mL, Folium Hippophae decoction liquor 8.5L adds in material-compound tank, and stirring and dissolving is centrifugal, gets supernatant, sterilization, fill, obtains Fructus Hippophae anti-inflammation collutory.
Embodiment 5
The preparation of Folium Hippophae decoction liquor:
Fresh Folium Hippophae is clean, add parch pot, 200 ℃ of high temperature of temperature complete fast, get the rear blade 1kg that completes, with the heating of 10L pure water, decoct 3 times, each 2 hours, merge, cooling, filtration makes Folium Hippophae extracting solution;
The refining thing preparation of Fructus Hippophae:
Fresh sea buckthorn fruit 1kg is cleaned, pulls an oar, by volumetric concentration, is that 50% alcohol heating reflux extracts, obtain extracting solution, then by extracting solution distilling under reduced pressure, reclaim ethanol, obtain Fructus Hippophae extracting solution;
By HPD-600 macroporous resin column on Fructus Hippophae extracting solution, by concentration, be that 10% ethanol rushes post, discard eluent, remove sugar and fruit acid, continue to rush post with 80% ethanol, eluent distilling under reduced pressure, reclaims ethanol, and spraying is dry, obtains the refining thing 58g of Fructus Hippophae;
The collutory that preparation total amount is 10L:
By the refining thing 40g of Fructus Hippophae, cumin essential oil 1g, xylitol 800g, glycerol 1L, Folium Hippophae decoction liquor 9L adds in material-compound tank, and stirring and dissolving is centrifugal, gets supernatant, sterilization, fill, obtains Fructus Hippophae anti-inflammation collutory.
Embodiment 6
Fructus Hippophae oropharynx anti-inflammation combination liquid Determination of Antibacterial Activity:
Get respectively solid LB culture medium 20mL, in microwave oven, be heated to boiling, be cooled to 37 ℃ of temperature, add respectively each 1mL of staphylococcus aureus bacterium liquid and Escherichia coli bacteria liquid, get again solid BHI culture medium 20mL, in microwave oven, be heated to boiling, be cooled to 37 ℃ of temperature, add Streptococcus mutans bacterium liquid 1mL, three kinds of culture medium are layered on culture dish respectively uniformly, after each culture medium cooled and solidified, with diameter 6mm iron pipe, in culture medium, punch, in hole, precision adds embodiment 1-5 gained Fructus Hippophae oropharynx anti-inflammation combination liquid 20 μ L respectively, until solution, absorb completely to culture medium, put into constant incubator, 37 ℃ of placement 24h of temperature, measure inhibition zone diameter, in Table 1:
Table 1 Fructus Hippophae oropharynx of the present invention anti-inflammation combination liquid antibacterial action testing result
Conclusion: Fructus Hippophae oropharynx anti-inflammation combination liquid of the present invention has good antibacterial action outward.
Embodiment 7
Fructus Hippophae oropharynx anti-inflammation combination liquid observation of curative effect:
By 64 routine patients (oral ulcer 36 examples, laryngopharynx swelling and pain 28 examples) be divided at random experimental group and matched group, every group of each 32 routine patients (oral ulcer 18 examples, laryngopharynx swelling and pain 14 examples), experimental group is used the Fructus Hippophae oropharynx anti-inflammation collutory of preparing by embodiment 1 method, and matched group is used commercially available collutory, use after the meal, each rinsing the mouth 30 seconds, is used 3 days continuously, during do not use other drug or oral care product.
In experiment, the present invention has obtained good curative effect: in the routine oral ulcer patient of experimental group 18,15 example recoveries from illness, 3 routine symptoms obviously alleviate, and in 14 routine laryngopharynx swelling and pain patients, 8 example recoveries from illness, 6 routine symptoms obviously alleviate, and total effective rate all reaches 100%; In the routine oral ulcer patient of matched group 18,9 routine patient's recoveries from illness, 7 routine symptoms alleviate, and in 14 routine laryngopharynx swelling and pain patients, 5 example recoveries from illness, 6 routine symptoms alleviate, and total effective rate is respectively 88.9% and 78.6% significantly lower than experimental group.
Conclusion: Fructus Hippophae oropharynx anti-inflammation combination liquid of the present invention has good treatment and alleviates the effect of oral ulcer and laryngopharynx swelling and pain.
Claims (4)
1. a Fructus Hippophae oropharynx anti-inflammation combines liquid, each component that it is characterized in that this combination liquid be take weight ratio as the refining thing 0-0.5% of Fructus Hippophae, plants essential oil is plant Herba Menthae, Fructus Cumini Cymini, Fructus Citri Limoniae, Flos Rosae Rugosae or the ginger essential oil 0.01-0.03% of edibility, sweeting agent is xylitol, sorbitol, stevioside or saccharin sodium 2-10%, cosolvent is glycerol or edible ethanol 3-15%, and Folium Hippophae decoction liquor 74.47-94.99% makes.
2. the preparation method of Fructus Hippophae oropharynx anti-inflammation combination liquid as claimed in claim 1, is characterized in that following these steps to carrying out:
A, fresh Folium Hippophae is clean, completes, and the pure water heating of doubly measuring with mass volume ratio 10-30 decocts, and extracts 1-4 time, and each 1-3 hour, merges, and cooling, filtration makes Folium Hippophae extracting solution;
B, fresh sea buckthorn fruit is clean, making beating, be that 30-70% alcohol heating reflux extracts by volumetric concentration, obtains extracting solution, then by extracting solution distilling under reduced pressure, reclaim ethanol, obtains Fructus Hippophae extracting solution;
Macroporous resin column on c, Fructus Hippophae extracting solution that step b is obtained, is that 0-10% ethanol rushes post by concentration, discards eluent, remove sugar and fruit acid, continuing is that 30-80% ethanol rushes post by volumetric concentration, eluent distilling under reduced pressure, reclaim ethanol, spraying is dry, obtains the refining thing of Fructus Hippophae;
D. to the Folium Hippophae extracting solution 74.47-94.99% that adds step a to obtain in material-compound tank, Fructus Hippophae is refined thing 0-0.5%, plants essential oil is plant Herba Menthae, Fructus Cumini Cymini, Fructus Citri Limoniae, Flos Rosae Rugosae or the ginger essential oil 0.01-0.03% of edibility, sweeting agent is xylitol, sorbitol, stevioside or saccharin sodium 2-10%, and cosolvent is glycerol or edible ethanol 3-15%, stirs, centrifugal, get supernatant sterilization, fill, obtains Fructus Hippophae oropharynx anti-inflammation combination liquid.
3. Fructus Hippophae oropharynx anti-inflammation according to claim 2 combines the preparation method of liquid, it is characterized in that in step c the macroporous resin that uses be polystyrene resin, polyacrylic acid resinoid or ion exchange resin, its model is AB-8, X-5, HPD-300, HPD-450, HPD-600 or HPD-700.
4. a Fructus Hippophae oropharynx anti-inflammation combination liquid as claimed in claim 1 is clean in preparation maintains oral cavity, and fresh breath, suppresses oral cavity bacterium breeding, alleviate oral ulcer, suppress oral inflammation, alleviate dental pain, the purposes in the medicine of alleviation gingival hemorrhage.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410388109.7A CN104127356B (en) | 2014-08-07 | 2014-08-07 | A kind of Fructus Hippophae oropharynx anti-inflammation combination liquid and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410388109.7A CN104127356B (en) | 2014-08-07 | 2014-08-07 | A kind of Fructus Hippophae oropharynx anti-inflammation combination liquid and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104127356A true CN104127356A (en) | 2014-11-05 |
| CN104127356B CN104127356B (en) | 2016-08-17 |
Family
ID=51800384
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410388109.7A Expired - Fee Related CN104127356B (en) | 2014-08-07 | 2014-08-07 | A kind of Fructus Hippophae oropharynx anti-inflammation combination liquid and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104127356B (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106727007A (en) * | 2017-01-02 | 2017-05-31 | 李大兴 | A kind of sea-buckthorn anti-aging toothpaste |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1308084A (en) * | 2001-02-13 | 2001-08-15 | 天津市阳成高科技天然制品有限公司 | Resin adsorption process of preparing sea-buckthorn flavone with sea-buckthorn leaf |
| CN101687000A (en) * | 2007-01-10 | 2010-03-31 | 高露洁-棕榄公司 | The oral care composition that contains Hippophne extract |
| CN102058634A (en) * | 2011-01-04 | 2011-05-18 | 鄂尔多斯市天骄资源发展有限责任公司 | Method for extracting and purifying total flavonoids of sea buckthorn |
| CN103054915A (en) * | 2012-12-13 | 2013-04-24 | 大兴安岭林格贝有机食品有限责任公司 | Novel production process for total flavones of hippophae rhamnoides |
| CN103417588A (en) * | 2013-08-23 | 2013-12-04 | 中国科学院新疆理化技术研究所 | Preparation method of effective part of Hippophae rhamnoides |
-
2014
- 2014-08-07 CN CN201410388109.7A patent/CN104127356B/en not_active Expired - Fee Related
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1308084A (en) * | 2001-02-13 | 2001-08-15 | 天津市阳成高科技天然制品有限公司 | Resin adsorption process of preparing sea-buckthorn flavone with sea-buckthorn leaf |
| CN101687000A (en) * | 2007-01-10 | 2010-03-31 | 高露洁-棕榄公司 | The oral care composition that contains Hippophne extract |
| CN102058634A (en) * | 2011-01-04 | 2011-05-18 | 鄂尔多斯市天骄资源发展有限责任公司 | Method for extracting and purifying total flavonoids of sea buckthorn |
| CN103054915A (en) * | 2012-12-13 | 2013-04-24 | 大兴安岭林格贝有机食品有限责任公司 | Novel production process for total flavones of hippophae rhamnoides |
| CN103417588A (en) * | 2013-08-23 | 2013-12-04 | 中国科学院新疆理化技术研究所 | Preparation method of effective part of Hippophae rhamnoides |
Non-Patent Citations (2)
| Title |
|---|
| P.S.NEGI等: "不同沙棘籽提取物的抗氧化和抗菌活性研究", 《国际沙棘研究与开发》 * |
| 金婷等: "沙棘中活性物质及其应用", 《沙棘》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106727007A (en) * | 2017-01-02 | 2017-05-31 | 李大兴 | A kind of sea-buckthorn anti-aging toothpaste |
Also Published As
| Publication number | Publication date |
|---|---|
| CN104127356B (en) | 2016-08-17 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN100420432C (en) | Gargle and its preparing process | |
| KR101743197B1 (en) | The manufacturing method of shampoo composition for caring scalp and promoting hair growth, and shampoo composition thereof | |
| CN105770191B (en) | With the composition and its preparation method and application for reducing Periodontal Pathogens active function | |
| CN101278994A (en) | Prinsepia utilis Royle oral nursing soft capsules | |
| CN103860423B (en) | A kind of have collutory of anti-inflammation deodorize and its production and use | |
| CN109528601B (en) | Compound traditional Chinese medicine mouth wash and preparation method thereof | |
| CN106535911B (en) | Oral composition for preventing and treating periodontitis containing cortex Mori extract and Euonymus Alata Sieb extract as active ingredients | |
| Dai et al. | Honey in traditional Chinese medicine: A guide to future applications of NADES to medicines | |
| CN101181208B (en) | Gargle containing natural antibiotics and preparation method thereof | |
| KR101760178B1 (en) | Composition comprising the extract of Hizikia Fusiforme for treating periodontal disease | |
| CN106377481B (en) | A method for extracting rhizoma Cyperi extract, and toothpaste and collutory containing the same | |
| CN107073061B (en) | Oral composition for preventing and treating dental caries comprising cortex Mori extract and Euonymus Alata Sieb extract as active ingredients | |
| CN106580779A (en) | Chinese herbal toothpaste with macadimia nut extract as main ingredient and preparation method thereof | |
| CN105997792A (en) | Traditional Chinese medicine mothproofing and tooth-protecting gargle and preparation method thereof | |
| CN104127356B (en) | A kind of Fructus Hippophae oropharynx anti-inflammation combination liquid and preparation method thereof | |
| CN104958233A (en) | Toothpaste for cat and preparation method of toothpaste | |
| CN110227103B (en) | Composition for resisting oral pathogenic bacteria and preparation method and application thereof | |
| CN105998528A (en) | Dental care tooth brushing powder | |
| CN111557889A (en) | Rose anthocyanin mouthwash and preparation method thereof | |
| CN110652465A (en) | Plant polypeptide nursing composition | |
| CN108354872A (en) | A kind of Chinese medicinal toothpaste and preparation method thereof | |
| CN108635310B (en) | Anti-inflammation toothpaste and preparation method thereof | |
| CN114642616B (en) | Mulberry leaf polyphenol-based mouthwash and preparation method thereof | |
| KR101609192B1 (en) | A method of preparing complex detergent for brushing teeth, washing, shaving and a complex detergent for brushing teeth, washing, shaving manufactured by the same | |
| KR20180098048A (en) | Mouthwash containing green tea |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20160817 Termination date: 20210807 |