CN101278994A - Prinsepia utilis Royle oral nursing soft capsules - Google Patents
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Abstract
The invention relates to a soft capsule of prinsepia utilis royle for mouth care and belongs to the technical field of nutrition and healthcare food. The technical proposal of the invention is a soft capsule of prinsepia utilis royle for mouth care, which is characterized in that the contents of the soft capsule are composed of 50 to 500 parts of prinsepia utilis royle oil. The soft capsule of the invention aims at providing the safe and nontoxic healthcare food which can effectively improve the dental ulcer, freshen the oral air and have the convenient administration.
Description
Technical field
The present invention relates to a kind of prinsepia utilis Royle oral nursing soft capsules, belong to nutritious health caring food technology field.
Background technology
Princepia utilis has another name called Folium Prinsepiae Utilis, rob the son fruit, A Nasi, be Rosaceae Prinsepia Royle plant, mainly is grown in mountain region, the barren hill of cloud, expensive, valley district height above sea level 1400-3100 rice, belongs to the woody oleiferous plants crop of a kind of " the happiness cold " of high and cold mountain area.The Princepia utilis whole body all is precious, and its tree, root, leaf, flower, fruit all have very high value, are the green products of pure natural.Modern scientific research confirms that Princepia utilis oil is rich in fatty acid and fat-soluble A, D, E, K and the various trace elements of multiple needed by human, is described as " eatable cosmetics " and " human body replenishes the new source of essential fatty acid " by nutritionist.According to " the southern regions of the Yunnan Province book on Chinese herbal medicine " record, " the Folium Prinsepiae Utilis bitter in the mouth, cold in nature.All cellulitis skin infection of assaulting the main target have dense person to lift one's head, and do not have that dense person is upright to disappear, eliminating stagnation nuclear." be usually used in controlling cellulitis skin infection, acute toothache; for hundreds of years; live in Naxi, the Yi nationality, distributed over Yunnan, Sichuan and Guizhou and the Mo Suo people of Lijing high and cold mountain area; be extensive use of Princepia utilis in the daily life, but appetite-stimulating indigestion-relieving, heat clearing away and internal heat reducing; to suppressing oral cavity and enteritis better action is arranged; people and animals' alimentary toxicosis is mashed Princepia utilis point, leaf that to extrude juice for oral administration, but dispelling toxicity, detoxicating.Outer wiping can be treated internal injury, traumatic injury, be sprained blood stasis etc., and its residue then has tangible reducing swelling and alleviating pain effect to skin infection.Because Princepia utilis oil is rich in unsaturated fatty acid, and its composition is approaching with the human body sebum, has very strong dermal osmosis ability, can promote to improve subcutaneous microcirculation, has the skin regeneration repair, and contained active ingredient has tangible transdermal to help the effect of oozing.
In daily life, no matter women or male, a lot of people had the worry of oral ulcer, and usually somehow or other occurs in the oral cavity, symptom reached a climax after 3～4 days, being mainly in the edge of oral mucosa and tongue, often is white ulcer, and blush is arranged on every side, ten minutes pain, when particularly meeting sour, salty, peppery food, pain is severe more, so that delicious food all is reluctant to taste." recurrent oral ulceration " medically is called in oral ulcer outbreak again and again, and recurrent oral ulceration is a modal disease in the diseases of oral mucosa, and prevalence occupies the first place of diseases of oral mucosa.Its recurrence time length and oral ulcer medical history have substantial connection, are mainly between twenty and fifty crowd between 20 years old to 50 years old, and be many with phenomenons such as constipation, halitosiss during morbidity.Oral ulcer mostly is due to the viral infection, and virus is promptly deposited in vivo after people are infected, ensconces subepidermal blood vessel, and breeds in nucleus, and when the health immune system abnormality, these viruses can be active especially, and the state of an illness also can obviously worsen.The oral ulcer of recurrent generally has the characteristics of oneself, generally shows effect on the lining mucosa of oral cavity, and outbreak but self limiting is arranged repeatedly, topical manifestations is isolated, circular or oval ulcer.Have " red, yellow, recessed, bitterly " four characteristics, red and swollen around the ulcer, but ulcer itself generally is xanchromatic, shape is recessed, usually pain relatively.From the outpatient, young and middle-aged people is the easiest ulcer to occur in the oral cavity, and the oral ulcer patient approximately can account for 1/3 in the outpatient service of periodontal mucosa section, and still commonplace, most of people were more or less perplexed by this problem.
The expert thinks that oral ulcer also belongs to a kind of " modern civilization disease ", because many patients are in overtired sequela, oral ulcer is sent out well between twenty and fifty people, all can take place throughout the year, especially summer, the days are long and the nights short, and temperature raises, and people sleep, stay up late than later, add that the modern practises in eating the oily food of barbecue, makes the easier generation of oral ulcer of febricity body constitution.Oral ulcer has " excessive fire in heart ", " retention of heat in the spleen and stomach ", " hyperactivity of fire caused by deficiency of YIN ", " Deficiency and coldness of spleen and stomach " to reach " liver-cold attacking the stomach " several types in the traditional Chinese medical science, and the Chinese traditional treatment oral ulcer is generally used the method for treatment of eliminating fire and detoxication, eliminating damp-heat.Except healing with medicine, can also use medicative diet for food therapy.The recurrent that can occur oral ulcer why, its cause of disease is still very not clear and definite at present, the reason that causes oral ulcer is a lot, be busy with one's work make people spiritual hypertonicity, anxious state of mind, do not have enough sleep, be easy to occur autonomic nervous dysfunction in this case, the chance of morbidity is just than higher.Infection by microorganisms such as antibacterial, virus, malnutrition, vitamin deficiency, the digestive system function disorder is as influences such as abdominal distention, diarrhoea or constipation.In addition, oral ulcer also is considered to relevant with factors such as heredity, hormone.
It is generally acknowledged suffer from periodontal disease, the people of diseases such as dental caries, oral ulcer, in mouthful one unpleasant stink is often arranged.When nasopharynx part and nasal cavity have inflammatory lesions or purulent secretion, also can cause halitosis.Halitosis is also relevant with digestive function imbalance, and this is because gastrointestinal function disorder or dyspepsia, people's salivary component is changed and presents acidity, helps the breeding activity of corrupt bacterioid, thereby causes halitosis.Halitosis belongs to gastrointestinal tract and has " heat ", therefore advocates to have the people of halitosis to eat less as far as possible and helps hot warming the interior group food, eats of the heat clearing away group food in right amount.The traditional Chinese medical science thinks that The mouth is the body opening or window of the spleen, and damp-heat in the spleen and stomach is smoked on the endogenous fire, and the diet discomfort causes gastrointestinal retention heat-transformation, liver and gall discord, heart spleen to give birth to heat, and halitosis will take place.Give vent to anger in mouthful smelly dirty be because of phlegm-heat obstructing in the lung, food stagnation, factor such as gastric heat or dyspepsia and causing.In addition, excessive, the regular psychentonia of mental pressure causes the health parasympathetic nervous to be in excitatory state, causes xerostomia, helps the anaerobe growth, and produces halitosis.The suitable determination of cause of disease according to differentiation of symptoms and signs of treatment primary disease is executed to the ill and is controlled, and notes oral hygiene, keeps happy, strengthening the spleen and nourishing the stomach, and oneself removes abnormal flavour.
The product that is used for mouth care at present uses the sterilization dosage form and the ionic surfactant of chemosynthesis more, have certain zest for the oral ulcer patient, and antibacterial is easy to generate Drug resistance.Having developed the oral care product principal mode is collutory, oral spray, chewing gum, toothpaste and oral care appliance, and mainly the soft capsule by the Princepia utilis oil preparation is applied to also not discovery of oral care product.
Summary of the invention
For addressing the above problem, the object of the present invention is to provide a kind of effective oral ulcer and abnormal flavour of improving, fresh breath, taking convenience, the nutritional health food of safety non-toxic.
For achieving the above object, the invention provides a kind of soft capsule of prinsepia utilis Royle oral nursing, soft capsule is made up of 50～500 parts of Princepia utilis oil and an amount of capsule material.
Princepia utilis oil is with the Princepia utilis seed vegetable oil that to be raw material make through advanced technology, kept the antiphlogistic composition of natural bacteriostatic in the Princepia utilis, be to strengthen the effect of Princepia utilis oil mouth care, can add in the following plants extract one or several, reach the effect of good mouth care.
Oleum menthae: have antiviral, anti-inflammation, convergence pain relieving, the lissive effect of being good for the stomach.Herba Menthae can improve spirit, allaying tiredness and bring pure and fresh comfort.On the traditional Chinese medical science, Herba Menthae tool wind-dispelling heat-dissipating is warded off dirty antidotal effect, cures mainly fever caused by exogenous pathogens, headache conjunctival congestion, laryngopharynx swelling and pain, dyspepsia flatulence, aphtha, toothache, and flu and respiratory tract and alimentary canal inflammation are useful for treating.
Fructus Citri Limoniae oil: Fructus Citri Limoniae is that one of fruit of medical value is arranged most.It is rich in vitamin C, citric acid, malic acid, a large amount sodium element and low amount potassium element, and is very useful to human body.Fructus Citri Limoniae contains abundant vitamin C, can effectively improve oral ulcer.And contain multivitamin A, C, E, P and B family, rich organic acid, flavonoid, coumarin, volatile oil, pectin etc.
Oleum Caryophylli: myrtle, mainly contain eugenol, aceteugenol, methyl salicylate, benzaldehyde, benzyl acetate, chavicol and flavone compound, Flos Caryophylli abnormal smells from the patient delicate fragrance, there is the anti-inflammatory analgetic effect in oral cavity and tooth, and the eugenol that wherein contains is used for the inflammation of gingiva pipe and toothache has extraordinary curative effect.
Flos Lonicerae: heat clearing away and internal heat reducing Chinese medicine commonly used, main effect is heat-clearing and toxic substances removing, dispelling wind and heat pathogens, for mouth care, heat clearing away and internal heat reducing, the effect of anti-inflammatory analgetic and removing abnormal flavor in oral cavity.Flos Lonicerae has the effect of multiple resisting pathogenic microbes, and its antibiotic effective ingredient is chlorogenic acid and isochlorogenic acid, cariogenic bacteria-Streptococcus mutans is had suppress preferably and bactericidal action.
Oil of Herba Pogostemonis: this product is the aerial parts of labiate Herba Pogostemonis, and herb has strong fragrance.Strong swash medicine and aromatic raw material are made with Herba Pogostemonis in Europe.Have on the Chinese medicine that arresting vomiting by invigorating the stomach, removing dampness are amusing, the diaphoresis equivalence, cure mainly experience heat-damp in summer, have a headache and fever, disease such as abdominal distention uncomfortable in chest, vomiting dysentery.Herba Agastaches Rugosae volatile oil can promote gastric secretion, strengthens eupepsy, and gastrointestinal tract is had spasmolysis.The Herba Pogostemonis decoct has inhibitory action to various skin pathomycete and leptospira.
Camellia oil: have the function of antiviral, bacteriostasis and sterilization, enhancing body immunity, to adapt to the stimulation and the destruction of external environment to human body.Camellia sinensis has extremely strong vitality, and oil-containing is abundant.The camellia oleosa seed insecticidal effect is fine, can control the tinea scabies.Camellia oil also can directly be used with the control mosquito bite, and good antipruritic effect is arranged.Dense Camellia oil can be removed wart, again can uvioresistant, prevent sunburn and wrinkle removing stricture of vagina.
Olive oil: for the Fructus oleae europaeae fruit passes through the pure natural fruit oil juice that the physics cold pressing process obtains in a short period of time after artificial the harvesting.Be rich in various antioxidant vitamin Es in the olive oil, carotenoid and phenolic compound, abundant trace element Squalene, Flavonoid substances, these materials prevent the cellular oxidation that free radical causes, prevent the damage that free radical causes, the interaction energy that plays the blood vessel street cleaner strengthens the immunity of human body, slow down aging.
Calcium lactate: white has and replenishes the calcium to off-white color crystalline powder or granule, and bone density improving improves the osteoporosis effect, consolidates tooth, and its absorbance is better than other calcium preparation.And calcium lactate can reduce capillary permeability and increase density, and effects such as antiinflammatory, anti-angiogenic mobility's edema and antiallergic are arranged.Be used for anaphylactic disease, tetany, rickets, various angor
Xylitol: xylitol be a kind ofly from materials such as corn cob, bagasse, extract, the novel sweetener and the senior treatment food of pure natural.Xylitol is the intermediate of human body carbohydate metabolism, also extensively exists at occurring in nature.Lacking insulin at human body influences under the glycometabolic situation, need not insulin and promotes, xylitol also can permeate through cell membranes be organized and absorbs, and can promote liver glycogen synthetic, improves liver function, is diabetes and hepatitis train wreck's ideal medicament.Simultaneously, this product is not produced dental caries in the oral cavity antibacterial utilizes, and can prevent dental caries.
Vitamin C: have the blood vessel elasticity of increasing and damaged tissue repair, promote the effect that collagen forms, this has just guaranteed that nutrient substance can unimpededly be transported to skin, promotes the firm of " support of skin ", and wrinkle is reduced, and gloss is recovered.Vitamin C continues performance and renders a service after spreading all over the horny layer depths, effectively suppresses melanin and generates, and reaches ideal whitening effect.
Vitamin B
2: the people of frequent stomatitis, the inflammation of mucosa can be supplemented with " anti-stomatitis vitamin " vitamin B in lip and the mouth
2Vitamin B
2Prevent and treat regular lip, tongue, oral ulcer, easily shed tears, blurred vision, cornea peripheral vessels hypertrophy, sclera is hemorrhage, seborrheic dermatitis etc.The vitamin B group allows fat change into the important substance of heat energy.
Vitamin E: a kind of basic nutrition element as important antioxidants, has the free radical of removing and eliminates lipofuscin deposition in the cell.Can prevent that body cell from destroying because of oxidation,, can improve lipid metabolism, promote cardiovascular health, prevent the generation of arteriosclerosis to delay histiocytic aging course.Vitamin E is to the protection of knife injury, scald, acne, senile plaque, chilblain, xerosis cutis and ultraviolet injury.
Glycyrrhizin: be the lyotropic salt made from the effective ingredient glycyrrhizic acid of Radix Glycyrrhizae sweet taste, has high sugariness, low heat energy, foaming characteristic and haemolysis are very low, safety non-toxic and stronger health-care effect, have detoxifcation, dental caries, anti-inflammatory, antiallergic action, effects such as anti-peptic ulcer blood fat reducing, AIDS virus resisting.In cosmetics, can be mixed with protective skin cream, the senior pearl cream of QUBAN SHUANG etc., existing beauty and skin care again can antiinflammatory, antiallergic action, effects such as treatment dermatosis.
Apple polyphenol: the brownish red powder, astringent taste and Fructus Mali pumilae fragrance are arranged, account for 25% based on the phenol carboxylic acid of chlorogenic acid, proanthocyanidin accounts for 50%, has very strong antioxidation, the different originality of antiallergic and resistance, caries prevention, beauty treatment, controlling blood pressure and reduction serum cholesterol.Be widely used in chewing gum, confection, cookies and the beverage in the U.S., Japan.
Green tea extract: mainly contain tea polyphenols, have slow down aging, resisting fatigue, anoxia enduring caries prevention, fresh breath effect.The antioxidation of green tea extract is all higher than vitamin C, all have clear and definite effect for eliminating the arteriosclerosis that intravital free radical, the effect of prevention LDL oxidation caused, the carrying out that suppresses carcinogen etc., tea polyphenols has inhibitory action to the different streptococcus m T8148 that brings out dental caries.
OPC: mainly contain polyphenols procyanidin (OPC), one of the strongest free radical scavenger that is up to now to be found, especially its activity in vivo is that other antioxidants are incomparable, its effect is ascorbic 20 times, 50 times of vitamin E.The good reputation that " skin vitamin ", " oral cosmetics " are arranged.Semen Vitis viniferae extract is natural sunlight overcover, can stop ultraviolet infringement skin, and the prevention scytitis keeps the soft and moist smooth of skin.
Herba Pileae Scriptae: containing lactone, volatile oil, organic acid, flavone compound, is the effective ingredient of Herba Pileae Scriptae anti-inflammation, is used for the treatment of the common inflammation disease more.Herba Pileae Scriptae extract has fungistatic effect preferably to staphylococcus aureus, escherichia coli, salmonella typhi, Aerugo first unit cell, organic acid has the obvious suppression effect to bacillus pyocyaneus, dysentery bacterium, group B streptococcus, and is outstanding for treatment oral inflammation curative effect.
Propolis: oral cavity health is had unique effect, killing rate to pathogenic bacterias such as staphylococcus aureus, escherichia coli, Candida albicans, funguses is 99%, propolis has the effect for the treatment of both the principal and secondary aspects of a disease to diseases such as halitosis, toothache, oral ulcer, periodontals, and propolis has local anesthesia, antiinflammatory, hemostasis, lenitive effect.
Folium hydrangeae strigosae: rosaceous plant, contain compositions such as pleasantly sweet glycosides, tannin, the aquiferous ethanol extracting solution of Folium hydrangeae strigosae can be used for treating gingivitis, can be used for preparing collutory, and for the treatment oral ulcer, removing halitosis has good effect.
Rhizoma Cimicifugae: ranunculaceae plant, contain cimicifugol., cimicifugoside, ferulic acid, caffeic acid, coumarin visnagin etc., the anti-inflammatory analgetic function is arranged, to dental caries swell and ache, pharyngalgia, aphtha have curative effect preferably, the effect that also has moistening to brighten to skin.
Radix Zanthoxyli: for reducing swelling and alleviating pain Chinese medicine commonly used among the people, contain alkaloid and flavonoid, have antiinflammatory, analgesia, effect such as antibiotic, anticancer.Be used for the treatment of various disease conditions such as toothache, neuralgia, stomachache, laryngopharynx swelling and pain, rheumatic arthritis, venom.
Flos Chrysanthemi Indici: effect with heat-clearing and toxic substances removing, antiphlogistic antibacterial, pure and fresh oral cavity.Periodontitis and gingivitis patients are had better curative effect, and life-time service helps to prevent and treat gingiva and periodontal, plays and improves oral cavity and the effect of dental health situation.
Magnolol: be the functional component of antibacterial action in the Chinese medicine Cortex Magnoliae Officinalis skin, magnolol can be dissolved in organic solvent, has the effect of well killing cariogenic bacteria, is prevention and the comparatively ideal medicine of treatment dental caries, is 0.63mg/ml to streptococcic minimum inhibitory concentration.
Paeonol: be the antimicrobial component of Chinese medicine Cortex Moutan, oil-soluble has stronger antibacterial action to staphylococcus aureus, streptococcus faecalis, escherichia coli etc., paeonol has analgesic activity, be a kind of morphine class analgesics, can safety be applied to food, in medicine and the daily use chemicals product.
For preparing suitable prinsepia utilis Royle oral nursing soft capsules, Princepia utilis oil can also add one or several in olive oil, Camellia oil, Oleum Hippophae, Semen Maydis oil, Oleum Arachidis hypogaeae semen, Semen Tritici aestivi germ oil, Oleum Vitis viniferae, safflower oil, almond oil, Radix Oenotherae erythrosepalae oil, Testa oryzae oil, perilla oil, Semen Lini oil, the soybean oil.
For strengthening prinsepia utilis Royle oral nursing soft capsules prevention and treatment oral ulcer, periodontal, remove the effect of halitosis, can add following natural materials, one or several in Fructus Mali pumilae, Radix Glycyrrhizae, Flos Lonicerae, Semen Vitis viniferae, Herba Houttuyniae, Flos Caryophylli, green tea, Folium hydrangeae strigosae, Flos Chrysanthemi, Flos Chrysanthemi Indici, Rhizoma Cimicifugae, Cortex Magnoliae Officinalis, Herba Pileae Scriptae, Cortex Moutan, Fructus Canarii, Semen Sterculiae Lychnophorae, Rhizoma Zingiberis Recens, Rhizoma Alpiniae Officinarum, Radix Zanthoxyli, Fructus Amomi, Fructus Alpiniae Oxyphyllae, Fructus Amomi Rotundus, Aloe, watermelon crystal, Rabdosia rubescens, fiery sour jujube, Radix Notoginseng, Rhizoma Coptidis, the propolis.
The present invention is used to improve oral ulcer, dispels halitosis, the antimicrobial formulation of refreshment.According to the oral hygiene principle, meet popular popular taste, can kill various pathogenic bacterium and virus in the oral cavity, moisten the maintenance oral mucosa, reach refreshment, fresh breath rapidly, the effect of human body immunity improving power.Prinsepia utilis Royle oral nursing soft capsules is non-stimulated to oral mucosa, and comprehensive mouth care can be provided, and is a kind of taking convenience, the nutritional health food of safety non-toxic.
The specific embodiment
Below in conjunction with specific embodiment prinsepia utilis Royle oral nursing soft capsules provided by the invention is specifically described, but the invention is not restricted to embodiment described below.
Embodiment 1: a kind of soft capsule of prinsepia utilis Royle oral nursing is by 500 parts of Princepia utilis oil, crosses 100 mesh sieves, medicinal liquid and capsule material is pressed into 500 of soft capsules on encapsulating machine, every heavily about 1.0g of soft capsule.
Embodiment 2: a kind of soft capsule of prinsepia utilis Royle oral nursing, 400 parts of Princepia utilis oil, 1～20 part of Oleum menthae, 1～50 part of Fructus Citri Limoniae oil, 5～50 parts of xylitol, vitamin e1～5 part.Mentioned component is stirred, cross 100 mesh sieves, medicinal liquid and capsule material are pressed into 500 of soft capsules on encapsulating machine, every heavily about 1.0g of soft capsule.
Embodiment 3: a kind of soft capsule of prinsepia utilis Royle oral nursing, 450 parts of Princepia utilis oil, 1～20 part of Oleum Caryophylli, 1～20 part of oil of Herba Pogostemonis, 10～50 parts of Camellia oil.Mentioned component is stirred, cross 100 mesh sieves, medicinal liquid and capsule material are pressed into 500 of soft capsules on encapsulating machine, every heavily about 1.0g of soft capsule.
Embodiment 4: a kind of soft capsule of prinsepia utilis Royle oral nursing, 300 parts of Princepia utilis oil add 1～5 part of calcium lactate, 1～5 part of vitamin C, vitamin B
21～10 part, 1～50 part of propolis, 10～200 parts in olive oil, 1～20 part of edible essence.Mentioned component is stirred, cross 100 mesh sieves, medicinal liquid and capsule material are pressed into 500 of soft capsules on encapsulating machine, every heavily about 1.0g of soft capsule.
Embodiment 5: a kind of soft capsule of prinsepia utilis Royle oral nursing, 380 parts of Princepia utilis oil, 1～5 part of apple polyphenol, 1～5 part of glycyrrhizin, 1～10 part of Oleum menthae, 1～20 part of Fructus Citri Limoniae oil, 1～20 part of edible essence, vitamin e1～10 part, 10～100 parts of xylitol.Mentioned component is stirred, cross 100 mesh sieves, medicinal liquid and capsule material are pressed into 500 of soft capsules on encapsulating machine, every heavily about 1.0g of soft capsule.
Embodiment 6: a kind of soft capsule of prinsepia utilis Royle oral nursing, 350 parts of Princepia utilis oil, 1～50 part of Flos Lonicerae extract, 1～50 part of green tea extract, 1～20 part of Radix Glycyrrhizae extract, 1～20 part of edible essence, 1～5 part of vitamin C, 5～50 parts in Cera Flava.By 500 of following prepared soft capsules, every heavily about 1.0g.
Preparation technology: Cera Flava is heated to fusion, mixes powerful the stirring 15 minutes with pressed powder and the vegetable oil of having pulverized 120 mesh sieves in the prescription, make its mix homogeneously, the degassing is pressed mill by colloid mill, form uniform and stable liquid, it is standby that mixed liquor is crossed 100 mesh sieves.With gelatin: glycerol: water: antiseptic=1: 0.4: 1.05: offset plate is made in 0.001 ratio dissolving can adhesive tape, mixed liquor is placed between two blocks of offset plates again, regulates out the thickness and the uniformity of rubber, forming with the punching block compacting.Continuous production adopts rotation Zhanang machine automatically, article two, the adhesive tape made automatically of machine moves round about, before arriving rotating mould, the part combination of having pressurizeed, this moment, medicinal liquid entered between adhesive tape through conduit from filling pump, rotate into groove, the whole roll compacting combinations of back adhesive tape, the soft capsule of making, cooling is fixing earlier, the reuse washing with alcohol is deoiled, and is drying to obtain.
Embodiment 7: a kind of soft capsule of prinsepia utilis Royle oral nursing, 250 parts of Princepia utilis oil, 1～5 part of apple polyphenol, 1～5 part of glycyrrhizin, 1～10 part of Oleum menthae, 10～150 parts of Flos Lonicerae extracts, 1～5 part of vitamin C, vitamin B
21～10 part, vitamin e1～10 part, 1～20 part of sweet tea extract, 1～20 part of edible essence, 5～50 parts in Cera Flava.Press the technology of embodiment 6,1000 of preparation soft capsules, every heavily about 0.5g.
Whether improving aspect the oral ulcer effectively for investigating blue or green perverse fruit oral nursing soft capsules, we carry out pharmacological experiment study.
One, prinsepia utilis Royle oral nursing soft capsules is to the influence of rat oral ulcer due to calcination and the glacial acetic acid
1. experimental technique: get 40 of male rats, body weight 180-220g, press the 1ml/100g anesthetized rat with 20% urethane, reuse normal saline flushing rat oral cavity, iron hoop with diameter 5mm burns heat back calcination rats with left oral mucosa then, and reuse includes the syringe of 90% glacial acetic acid perpendicular to calcination position contact 30s.Observe behind the 24h, 100% rat is all caused heavy ulcer surface.Ulcer reaches the mucosa deep layer, the epithelial cell necrosis, comes off, and inflammatory exudation is arranged, and tissue is red and swollen simultaneously, hyperemia, the twinge positive.Random packet, is divided 4 groups, i.e. model group (normal saline) by 10 every group; Prinsepia utilis Royle oral nursing soft capsules low dose group (soft capsule content 2 times/day); Dosage group in the prinsepia utilis Royle oral nursing soft capsules (soft capsule content 4 times/day); Prinsepia utilis Royle oral nursing soft capsules high dose group (soft capsule content 8 times/day); Prinsepia utilis Royle oral nursing soft capsules content flap coverage is degree.Successive administration 5 days, first administration to last administration is recorded as 0,1,2,3,4,5 day respectively next day, observe ulcer area size (in the diameter of ulcer) and ulcer healing situation (do not have macroscopic ulcer and be considered as healing) next day before the administration and after each administration, ulcer area size is checked with t, ulcer healing situation x
2Check the results are shown in Table 1, table 2
Table 1 prinsepia utilis Royle oral nursing soft capsules is to the influence of rat oral ulcer area
* compare P＜0.05 with model group
* and model group be P＜0.01 relatively
The influence of table 2 prinsepia utilis Royle oral nursing soft capsules rat oral ulcer healing time
* compare P＜0.05 with model group
* and model group be P＜0.01 relatively
The ulcer area compares: played experiment in 5 days on the 1st day from administration and finish, significant difference (P＜0.05) has been compared in prinsepia utilis Royle oral nursing soft capsules low dose group administration the 4th, 5 days with model group; The administration of dosage group is compared with model group in the prinsepia utilis Royle oral nursing soft capsules, and significant difference (P＜0.05) was arranged on the 3rd day, and utmost point significant difference (P＜0.01) was arranged on the the 4th, 5 day; The administration of prinsepia utilis Royle oral nursing soft capsules high dose group was compared utmost point significant difference (P＜0.01) since the 2nd day with model group, can obviously dwindle the area of rat oral ulcer.
Ulcer healing rate: model group finishes to experiment from administration the 1st day, and ulcer is healing not; The administration of prinsepia utilis Royle oral nursing soft capsules low dose group rose on the 4th day, and ulcer healing is arranged, and finished to experiment, and healing rate reaches 30%; Dosage group in the prinsepia utilis Royle oral nursing soft capsules rose on the 3rd day, and ulcer healing is arranged, and finished to experiment, and healing rate reaches 80%; The prinsepia utilis Royle oral nursing soft capsules high dose group rose on the 2nd day, and ulcer healing is arranged, and finished to experiment, and healing rate reaches 90%.
From above-mentioned experimental result as can be known, the middle and high dosage group of prinsepia utilis Royle oral nursing soft capsules improves significantly to the tool of rat oral ulcer due to calcination and the glacial acetic acid, can significantly dwindle the area of oral ulcer, improves the healing rate of oral ulcer.
Two, prinsepia utilis Royle oral nursing soft capsules is to the influence of rat oral ulcer due to the Candida albicans
1. experimental technique: get 40 of male rats, body weight 180-220g presses the 1ml/100g anesthetized rat with 20% urethane, and the Candida albicans bacterium liquid 0.07ml with 1,500,000,000 CFU/ml after the anesthesia injects under the rat oral mucosa, the pus that forms after 48 hours is cooked diabrosis voluntarily, forms ulcer.Random packet, is divided 4 groups, i.e. model group (normal saline) by 10 every group; Prinsepia utilis Royle oral nursing soft capsules low dose group (soft capsule content 2 times/day); Dosage group in the prinsepia utilis Royle oral nursing soft capsules (soft capsule content 4 times/day); Prinsepia utilis Royle oral nursing soft capsules high dose group (soft capsule content 8 times/day); Prinsepia utilis Royle oral nursing soft capsules content flap coverage is degree.Successive administration 5 days, first administration to last administration is recorded as 0,1,2,3,4,5 day respectively next day, observe ulcer area size (in the diameter of ulcer) and ulcer healing situation (do not have macroscopic ulcer and be considered as healing) next day before the administration and after each administration, ulcer area size is checked with t, ulcer healing situation x
2Check, experimental result see Table 3, table 4.
Table 3 prinsepia utilis Royle oral nursing soft capsules is to the influence of rat oral ulcer area
* compare P＜0.05 with model group
* and model group be P＜001 relatively
The influence of table 4 prinsepia utilis Royle oral nursing soft capsules rat oral ulcer healing time
* compare P＜0.05 with model group
* and model group be P＜0.01 relatively
The ulcer area compares: played experiment in 5 days on the 1st day from administration and finish, significant difference (P＜0.05) has been compared in prinsepia utilis Royle oral nursing soft capsules low dose group administration the 5th day with model group; The administration of the middle and high dosage group of prinsepia utilis Royle oral nursing soft capsules is compared with model group, since the 2nd day, has compared utmost point significant difference (P＜0.01) with model group, can obviously dwindle the area of rat oral ulcer.
Ulcer healing rate: model group finishes from administration experiment in the 1st day to 5 days, and ulcer is healing not; Prinsepia utilis Royle oral nursing soft capsules low dose group administration the 5th day has ulcer healing, and experiment finishes, and healing rate reaches 30%; Dosage group in the prinsepia utilis Royle oral nursing soft capsules rose on the 2nd day, and ulcer healing is arranged, and finished to experiment, and healing rate reaches 80%; The prinsepia utilis Royle oral nursing soft capsules high dose group rose on the 2nd day, and ulcer healing is arranged, and finished to experiment, and healing rate reaches 90%.
From above-mentioned experimental result as can be known, the middle and high dosage group of prinsepia utilis Royle oral nursing soft capsules improves significantly to rat oral ulcer oral ulcer tool due to the Candida albicans, can significantly dwindle the area of oral ulcer, improves the healing rate of oral ulcer.Prinsepia utilis Royle oral nursing soft capsules is advised into buccal in the human mouth (chewing clothes), specification: 1.0g/ grain, every day 2 times, each 1.
Claims (9)
1. the soft capsule of a prinsepia utilis Royle oral nursing is characterized in that described soft capsule content is made up of for 50～500 parts Princepia utilis oil.
2. according to the described prinsepia utilis Royle oral nursing soft capsules of claim 1, its feature can also add 1～20 part of Oleum menthae, 1～50 part of Fructus Citri Limoniae oil, 5～50 parts of xylitol, vitamin e1～5 part.
3. prinsepia utilis Royle oral nursing soft capsules according to claim 1, its feature can also add 1～20 part of Oleum Caryophylli, 1～20 part of oil of Herba Pogostemonis, 10～50 parts of Camellia oil.
4. prinsepia utilis Royle oral nursing soft capsules according to claim 1 is characterized in that adding 1～5 part of calcium lactate, 1～5 part of vitamin C, vitamin B
21～10 part, 1～50 part of propolis, 10～200 parts in olive oil, 1～20 part of edible essence.
5. prinsepia utilis Royle oral nursing soft capsules according to claim 1, it is characterized in that to add 1～50 part of Flos Lonicerae extract, 1～50 part of green tea extract, 1～20 part of Radix Glycyrrhizae extract, 1～20 part of edible essence, 1～5 part of vitamin C, 5～50 parts in Cera Flava.
6. prinsepia utilis Royle oral nursing soft capsules according to claim 1, its feature can also add 1～5 part of apple polyphenol, 1～5 part of glycyrrhizin, 1～10 part of Oleum menthae, 1～20 part of Fructus Citri Limoniae oil, 1～20 part of edible essence, vitamin e1～10 part, 10～100 parts of xylitol.
7. prinsepia utilis Royle oral nursing soft capsules according to claim 1, its feature can also add 1～5 part of apple polyphenol, 1～5 part of glycyrrhizin, 1～10 part of Oleum menthae, 10～100 parts of Flos Lonicerae extracts, 1～5 part of vitamin C, vitamin B
21～10 part, vitamin e1～10 part, 1～20 part of sweet tea extract, 1～20 part of edible essence, 5～50 parts in Cera Flava.
8. prinsepia utilis Royle oral nursing soft capsules according to claim 1 is characterized in that soft capsule can also add one or several in olive oil, Camellia oil, Oleum Hippophae, Semen Maydis oil, Oleum Arachidis hypogaeae semen, Semen Tritici aestivi germ oil, Oleum Vitis viniferae, safflower oil, almond oil, Radix Oenotherae erythrosepalae oil, Testa oryzae oil, perilla oil, Semen Lini oil, the soybean oil.
9. prinsepia utilis Royle oral nursing soft capsules according to claim 1, it is characterized in that described soft capsule can add the following plants extract, one or several in Fructus Mali pumilae, Radix Glycyrrhizae, Flos Lonicerae, Herba Houttuyniae, Flos Caryophylli, Herba Pogostemonis, green tea, Folium hydrangeae strigosae, Flos Chrysanthemi, Flos Chrysanthemi Indici, Rhizoma Cimicifugae, Cortex Magnoliae Officinalis, Herba Pileae Scriptae, Cortex Moutan, Fructus Canarii, Semen Sterculiae Lychnophorae, Rhizoma Zingiberis Recens, Rhizoma Alpiniae Officinarum, Radix Zanthoxyli, Fructus Amomi, Fructus Alpiniae Oxyphyllae, Fructus Amomi Rotundus, Aloe, watermelon crystal, Rabdosia rubescens, fiery sour jujube, Radix Notoginseng, the Rhizoma Coptidis.
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| CNA2007100907451A CN101278994A (en) | 2007-04-06 | 2007-04-06 | Prinsepia utilis Royle oral nursing soft capsules |
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| CN104473267B (en) * | 2014-11-13 | 2016-08-17 | 董珉 | Folium hydrangeae strigosae beverage with oral cavity health function and preparation method thereof |
| CN104473267A (en) * | 2014-11-13 | 2015-04-01 | 董珉 | Folium rubi suavissimi beverage having oral cavity health-care function and preparation method thereof |
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| CN106177269A (en) * | 2016-07-07 | 2016-12-07 | 万苏晨 | The pharmaceutical composition of quick curing oral keritonocytes, preparation method and application |
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