CN108308611A - A kind of chewable tablets and preparation method thereof for capableing of fresh breath - Google Patents
A kind of chewable tablets and preparation method thereof for capableing of fresh breath Download PDFInfo
- Publication number
- CN108308611A CN108308611A CN201711475291.XA CN201711475291A CN108308611A CN 108308611 A CN108308611 A CN 108308611A CN 201711475291 A CN201711475291 A CN 201711475291A CN 108308611 A CN108308611 A CN 108308611A
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- CN
- China
- Prior art keywords
- parts
- dry
- sponge gourd
- chewable tablets
- capableing
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- 239000007910 chewable tablet Substances 0.000 title claims abstract description 34
- 238000002360 preparation method Methods 0.000 title abstract description 8
- 244000302544 Luffa aegyptiaca Species 0.000 claims abstract description 45
- 235000009814 Luffa aegyptiaca Nutrition 0.000 claims abstract description 45
- 244000246386 Mentha pulegium Species 0.000 claims abstract description 25
- 235000016257 Mentha pulegium Nutrition 0.000 claims abstract description 25
- 235000004357 Mentha x piperita Nutrition 0.000 claims abstract description 25
- 235000001050 hortel pimenta Nutrition 0.000 claims abstract description 25
- 239000011122 softwood Substances 0.000 claims abstract description 24
- 235000013871 bee wax Nutrition 0.000 claims abstract description 21
- 239000012166 beeswax Substances 0.000 claims abstract description 21
- 238000009736 wetting Methods 0.000 claims abstract description 16
- DLRVVLDZNNYCBX-RTPHMHGBSA-N isomaltose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)C(O)O1 DLRVVLDZNNYCBX-RTPHMHGBSA-N 0.000 claims abstract description 13
- 239000002994 raw material Substances 0.000 claims abstract description 13
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 11
- 239000000314 lubricant Substances 0.000 claims abstract description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 13
- 201000010099 disease Diseases 0.000 claims description 12
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 12
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 10
- 241000607479 Yersinia pestis Species 0.000 claims description 9
- 239000012267 brine Substances 0.000 claims description 9
- 238000004140 cleaning Methods 0.000 claims description 9
- 238000000034 method Methods 0.000 claims description 9
- HPALAKNZSZLMCH-UHFFFAOYSA-M sodium;chloride;hydrate Chemical compound O.[Na+].[Cl-] HPALAKNZSZLMCH-UHFFFAOYSA-M 0.000 claims description 9
- 238000001035 drying Methods 0.000 claims description 6
- 238000002156 mixing Methods 0.000 claims description 6
- 238000009777 vacuum freeze-drying Methods 0.000 claims description 6
- 235000019441 ethanol Nutrition 0.000 claims description 5
- FPAFDBFIGPHWGO-UHFFFAOYSA-N dioxosilane;oxomagnesium;hydrate Chemical compound O.[Mg]=O.[Mg]=O.[Mg]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O FPAFDBFIGPHWGO-UHFFFAOYSA-N 0.000 claims description 4
- 238000000605 extraction Methods 0.000 claims description 4
- 238000007654 immersion Methods 0.000 claims description 4
- 239000000203 mixture Substances 0.000 claims description 4
- 108090000623 proteins and genes Proteins 0.000 claims description 4
- 102000004169 proteins and genes Human genes 0.000 claims description 4
- 239000002002 slurry Substances 0.000 claims description 4
- 235000000346 sugar Nutrition 0.000 claims description 4
- 235000007516 Chrysanthemum Nutrition 0.000 claims description 3
- 244000189548 Chrysanthemum x morifolium Species 0.000 claims description 3
- 108010010803 Gelatin Proteins 0.000 claims description 3
- 235000011229 Prunus domestica subsp. syriaca Nutrition 0.000 claims description 3
- 244000169641 Spondias dulcis Species 0.000 claims description 3
- 235000005138 Spondias dulcis Nutrition 0.000 claims description 3
- 238000001914 filtration Methods 0.000 claims description 3
- 239000008273 gelatin Substances 0.000 claims description 3
- 229920000159 gelatin Polymers 0.000 claims description 3
- 235000019322 gelatine Nutrition 0.000 claims description 3
- 235000011852 gelatine desserts Nutrition 0.000 claims description 3
- 229930182470 glycoside Natural products 0.000 claims description 3
- 150000002338 glycosides Chemical class 0.000 claims description 3
- 239000012535 impurity Substances 0.000 claims description 3
- 229920000609 methyl cellulose Polymers 0.000 claims description 3
- 239000001923 methylcellulose Substances 0.000 claims description 3
- 235000010981 methylcellulose Nutrition 0.000 claims description 3
- KSDSYIXRWHRPMN-UHFFFAOYSA-N 4'-O-beta-D-Galactopyranoside-6''-p-Coumaroylprunin-4',5,7-Trihydroxyflavanone Natural products OC1C(O)C(O)C(CO)OC1OC1=CC=C(C2OC3=CC(O)=CC(O)=C3C(=O)C2)C=C1 KSDSYIXRWHRPMN-UHFFFAOYSA-N 0.000 claims description 2
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 claims description 2
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims description 2
- DEMKZLAVQYISIA-ONJCETCRSA-N Liquiritin Natural products O([C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1)c1ccc([C@@H]2Oc3c(C(=O)C2)ccc(O)c3)cc1 DEMKZLAVQYISIA-ONJCETCRSA-N 0.000 claims description 2
- DEMKZLAVQYISIA-UHFFFAOYSA-N Liquirtin Natural products OC1C(O)C(O)C(CO)OC1OC1=CC=C(C2OC3=CC(O)=CC=C3C(=O)C2)C=C1 DEMKZLAVQYISIA-UHFFFAOYSA-N 0.000 claims description 2
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 claims description 2
- 235000010489 acacia gum Nutrition 0.000 claims description 2
- 239000001785 acacia senegal l. willd gum Substances 0.000 claims description 2
- 239000012141 concentrate Substances 0.000 claims description 2
- 239000008101 lactose Substances 0.000 claims description 2
- 229960001375 lactose Drugs 0.000 claims description 2
- DEMKZLAVQYISIA-ZRWXNEIDSA-N liquiritin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=CC=C([C@H]2OC3=CC(O)=CC=C3C(=O)C2)C=C1 DEMKZLAVQYISIA-ZRWXNEIDSA-N 0.000 claims description 2
- 239000000845 maltitol Substances 0.000 claims description 2
- VQHSOMBJVWLPSR-WUJBLJFYSA-N maltitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O VQHSOMBJVWLPSR-WUJBLJFYSA-N 0.000 claims description 2
- 235000010449 maltitol Nutrition 0.000 claims description 2
- 229940035436 maltitol Drugs 0.000 claims description 2
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 claims description 2
- GSZUGBAEBARHAW-UHFFFAOYSA-N sophoraflavone B Natural products OC1C(O)C(O)C(CO)OC1OC1=CC=C(C=2OC3=CC(O)=CC=C3C(=O)C=2)C=C1 GSZUGBAEBARHAW-UHFFFAOYSA-N 0.000 claims description 2
- 239000000811 xylitol Substances 0.000 claims description 2
- 235000010447 xylitol Nutrition 0.000 claims description 2
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 claims description 2
- 229960002675 xylitol Drugs 0.000 claims description 2
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 claims 1
- 235000014113 dietary fatty acids Nutrition 0.000 claims 1
- 239000000194 fatty acid Substances 0.000 claims 1
- 229930195729 fatty acid Natural products 0.000 claims 1
- 150000004665 fatty acids Chemical class 0.000 claims 1
- 229910052749 magnesium Inorganic materials 0.000 claims 1
- 239000011777 magnesium Substances 0.000 claims 1
- 239000007779 soft material Substances 0.000 claims 1
- 206010006326 Breath odour Diseases 0.000 abstract description 20
- 208000032139 Halitosis Diseases 0.000 abstract description 18
- 210000000214 mouth Anatomy 0.000 abstract description 11
- 230000001055 chewing effect Effects 0.000 abstract description 5
- 150000001875 compounds Chemical class 0.000 abstract description 5
- 102000016943 Muramidase Human genes 0.000 abstract description 4
- 108010014251 Muramidase Proteins 0.000 abstract description 4
- 108010062010 N-Acetylmuramoyl-L-alanine Amidase Proteins 0.000 abstract description 4
- 235000010335 lysozyme Nutrition 0.000 abstract description 4
- 239000004325 lysozyme Substances 0.000 abstract description 4
- 229960000274 lysozyme Drugs 0.000 abstract description 4
- 210000001124 body fluid Anatomy 0.000 abstract description 3
- 239000010839 body fluid Substances 0.000 abstract description 3
- 238000004519 manufacturing process Methods 0.000 abstract description 3
- 230000003902 lesion Effects 0.000 abstract description 2
- 210000003296 saliva Anatomy 0.000 abstract description 2
- 230000028327 secretion Effects 0.000 abstract description 2
- 235000012970 cakes Nutrition 0.000 description 19
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical group [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 8
- 230000000052 comparative effect Effects 0.000 description 7
- 235000019359 magnesium stearate Nutrition 0.000 description 4
- 241000894006 Bacteria Species 0.000 description 3
- 229920002472 Starch Polymers 0.000 description 3
- 239000008107 starch Substances 0.000 description 3
- 235000019698 starch Nutrition 0.000 description 3
- 241000193830 Bacillus <bacterium> Species 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- 235000009508 confectionery Nutrition 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 239000000796 flavoring agent Substances 0.000 description 2
- 235000019634 flavors Nutrition 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- 210000004185 liver Anatomy 0.000 description 2
- 229920001542 oligosaccharide Polymers 0.000 description 2
- 238000003809 water extraction Methods 0.000 description 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- 206010011224 Cough Diseases 0.000 description 1
- 244000241257 Cucumis melo Species 0.000 description 1
- 235000015510 Cucumis melo subsp melo Nutrition 0.000 description 1
- 235000001453 Glycyrrhiza echinata Nutrition 0.000 description 1
- 244000303040 Glycyrrhiza glabra Species 0.000 description 1
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 description 1
- 235000017382 Glycyrrhiza lepidota Nutrition 0.000 description 1
- 206010062717 Increased upper airway secretion Diseases 0.000 description 1
- AFCARXCZXQIEQB-UHFFFAOYSA-N N-[3-oxo-3-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)propyl]-2-[[3-(trifluoromethoxy)phenyl]methylamino]pyrimidine-5-carboxamide Chemical compound O=C(CCNC(=O)C=1C=NC(=NC=1)NCC1=CC(=CC=C1)OC(F)(F)F)N1CC2=C(CC1)NN=N2 AFCARXCZXQIEQB-UHFFFAOYSA-N 0.000 description 1
- 206010068319 Oropharyngeal pain Diseases 0.000 description 1
- 201000007100 Pharyngitis Diseases 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- 208000005392 Spasm Diseases 0.000 description 1
- 235000021307 Triticum Nutrition 0.000 description 1
- 244000098338 Triticum aestivum Species 0.000 description 1
- FJJCIZWZNKZHII-UHFFFAOYSA-N [4,6-bis(cyanoamino)-1,3,5-triazin-2-yl]cyanamide Chemical compound N#CNC1=NC(NC#N)=NC(NC#N)=N1 FJJCIZWZNKZHII-UHFFFAOYSA-N 0.000 description 1
- 239000012752 auxiliary agent Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 229940112822 chewing gum Drugs 0.000 description 1
- 235000015218 chewing gum Nutrition 0.000 description 1
- 238000002405 diagnostic procedure Methods 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- IDGUHHHQCWSQLU-UHFFFAOYSA-N ethanol;hydrate Chemical compound O.CCO IDGUHHHQCWSQLU-UHFFFAOYSA-N 0.000 description 1
- 125000005909 ethyl alcohol group Chemical group 0.000 description 1
- 210000003128 head Anatomy 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- 229940010454 licorice Drugs 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- -1 malt Oligosaccharide Chemical class 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 239000002324 mouth wash Substances 0.000 description 1
- 229940051866 mouthwash Drugs 0.000 description 1
- 230000009965 odorless effect Effects 0.000 description 1
- 150000002482 oligosaccharides Chemical class 0.000 description 1
- 208000026435 phlegm Diseases 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 238000002137 ultrasound extraction Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L19/00—Products from fruits or vegetables; Preparation or treatment thereof
- A23L19/01—Instant products; Powders; Flakes; Granules
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L19/00—Products from fruits or vegetables; Preparation or treatment thereof
- A23L19/03—Products from fruits or vegetables; Preparation or treatment thereof consisting of whole pieces or fragments without mashing the original pieces
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L21/00—Marmalades, jams, jellies or the like; Products from apiculture; Preparation or treatment thereof
- A23L21/20—Products from apiculture, e.g. royal jelly or pollen; Substitutes therefor
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/125—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives containing carbohydrate syrups; containing sugars; containing sugar alcohols; containing starch hydrolysates
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
- A23P10/00—Shaping or working of foodstuffs characterised by the products
- A23P10/20—Agglomerating; Granulating; Tabletting
- A23P10/28—Tabletting; Making food bars by compression of a dry powdered mixture
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Nutrition Science (AREA)
- Mycology (AREA)
- Botany (AREA)
- Molecular Biology (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
A kind of chewable tablets and preparation method thereof for capableing of fresh breath, the chewable tablets be after softwood is made in raw material addition wetting aid, then softwood is granulated, dry, tabletting forms, raw material is made of the component of following parts by weight:0.5 ~ 1 part of isomalto-oligosaccharide, 10 ~ 20 parts of peppermint, 9 ~ 11 parts of beeswax, 8 ~ 10 parts of Radix Glycyrrhizae, 20 ~ 45 parts of Loquat-Shaped Cake, sponge gourd be 0.5 ~ 1 part dry, 1 ~ 2 part of dried plum, 1.5 ~ 10 parts of corrigent, 5 ~ 20 parts of forming agent and 5 ~ 10 parts of lubricant.The residue that dental surface can be removed in the chewable tablets of the present invention in chewing containing the dry sponge gourd complex compound with dried plum sponge gourd in dry of filamentous sponge gourd, prevents the halitosis caused by foreign matter remains;It promotes the production of body fluid after dried plum chewing, increases the secretion of saliva, and then increase the lysozyme generated in oral cavity, further remove the lesion of mouth source property halitosis.
Description
Technical field
The present invention relates to technical field of food deep processing, and in particular to a kind of chewable tablets that capableing of fresh breath and its preparation
Method.
Background technology
Halitosis also known as gas is smelly, implication it is dirty dislike, implication it is smelly, in the allegro modern life, incidence is in raising trend.
Most halitosis is mainly caused by back microorganism, slot microbial growth, and halitosis is that one kind that halitosis bacillus causes is normal
See that disease, the lysozyme generated in human oral cavity determine whether there are the presence of halitosis, halitosis bacillus mainly breeds in slot, leans on
Intraoral bacterium life is decomposed, can generally control it is intraoral lysozyme.Bad Breath Treatment is used on existing market
Product, mostly for the purpose of fresh breath, such as chewing gum, mouthwash, mouth sprays, lacking one kind being capable of comprehensive alleviation mouth
The product of source property halitosis.
Invention content
It is an object of the present invention to provide a kind of chewable tablets and preparation method thereof for capableing of fresh breath, being capable of compound improvement mouth source
Property halitosis.
Present invention technical solution used for the above purpose is as follows:A kind of chewable tablets for capableing of fresh breath, should
Chewable tablets is after softwood is made in raw material addition wetting aid, then softwood is granulated, dry, tabletting forms, raw material is by following heavy
Measure the component composition of part:0.5 ~ 1 part of isomalto-oligosaccharide, 10 ~ 20 parts of peppermint, 9 ~ 11 parts of beeswax, 8 ~ 10 parts of Radix Glycyrrhizae, Loquat-Shaped Cake 20
~ 45 parts, sponge gourd is 0.5 ~ 1 part dry, 1 ~ 2 part of dried plum, 1.5 ~ 10 parts of corrigent, 5 ~ 20 parts of forming agent and 5 ~ 10 parts of lubricant.
Wherein, corrigent is using one in chrysanthemum glycosides, liquiritin, protein sugar, maltitol, xylitol, lactose, sorbierite
Kind.
Wherein, forming agent is using one kind in starch slurry, Arabic gum, gelatin or methylcellulose.
Wherein, lubricant is magnesium stearate or talcum powder.
In the present invention, wetting aid is 10 ~ 12 by volume ratio:0 ~ 2 sponge gourd water and ethyl alcohol composition.Different wheat in the present invention
Bud oligosaccharide is the product bought in the market.
In the present invention, sponge gourd water is prepared using following methods:Take the sponge gourd of fresh no disease and pests harm, stripping and slicing after cleaning,
It is put into after impregnating 2 ~ 4h in a concentration of 3 ~ 5% brine and dries;Sponge gourd block is placed in extraction kettle and is extracted, extract liquor is obtained
A;Extract liquor A is discarded into filter residue after 20 ~ 80 mesh screens, centrifugal filtration after 15 ~ 45min is stood, obtains extract liquor B;It will extraction
It takes liquid B films to concentrate or reduced vacuum is concentrated into 60 ~ 65Brix, the sponge gourd water after being concentrated.
A kind of preparation method of chewable tablets that capableing of fresh breath, includes the following steps:
(1), take the yellow plum of fresh no disease and pests harm, cleaning to dry after chop up silk, be put into 2 ~ 4h of immersion in a concentration of 3 ~ 5% brine,
After drying, be fried with slow fire it is micro- have focal spot, be made dried plum, it is spare;
(2), take the sponge gourd of fresh no disease and pests harm, cleaning to dry after chop up silk, be put into 2 ~ 4h of immersion in a concentration of 3 ~ 5% brine,
After drying, be fried with slow fire it is micro- have focal spot, it is dry to be made sponge gourd, spare;
(3), choose without the Loquat-Shaped Cake that goes mouldy, dried after removing impurity, ted after it is most probably dry and once parched completely to it;So
It will be crushed after Loquat-Shaped Cake vacuum freeze drying afterwards, cross 100 ~ 120 mesh sieve, obtain powdered Loquat-Shaped Cake;
(4), beeswax, Radix Glycyrrhizae and peppermint are distinguished into vacuum freeze drying after crush, then cross 100 ~ 120 mesh sieve, obtain powdered
Beeswax, Radix Glycyrrhizae and peppermint;
(5), according to the parts by weight of component in above-mentioned raw materials, take 0.5 ~ 1 part of isomalto-oligosaccharide, step(1)Dried plum obtained, step
Suddenly(2)Sponge gourd obtained is dry, step(3)Loquat-Shaped Cake obtained, step(4)Peppermint, beeswax and Radix Glycyrrhizae obtained are uniformly mixed,
Then wetting aid is added and forms softwood, the standard for adding the amount of wetting aid is:Softwood is set to hold agglomerating, light pressure dissipates,
It is non-sticky to hold rear palm;
(6), according to the parts by weight of component in above-mentioned raw materials, take corrigent, forming agent and lubricant to be added in softwood, mixing is equal
After even, dried in 50 ~ 55 DEG C of baking oven to moisture and be down to 5% hereinafter, tabletting, is made chewable tablets finished product.
It has the beneficial effect that:Since the stickiness of beeswax is very strong, the swill of dental surface can be removed, is avoided because of food
Halitosis caused by residue;Added with peppermint and Loquat-Shaped Cake, oral cavity fresh and cool can be kept.
It is done containing filamentous sponge gourd in the chewable tablets of the present invention and dried plum, the two is rich in cellulosic, potassium, calcium and a variety of dimensions
Raw element, and sponge gourd it is dry in sponge gourd complex compound the residue of dental surface can be removed in chewing, prevent from making because of foreign matter residual
At halitosis;It promotes the production of body fluid after dried plum chewing, increases the secretion of saliva, and then increase the lysozyme generated in oral cavity, further remove
The lesion of mouth source property halitosis.
Specific implementation mode
The present invention is further explained in the light of specific embodiments, so that those skilled in the art can be better
Understand the present invention and can be practiced.
A kind of chewable tablets for capableing of fresh breath, the chewable tablets be by raw material addition wetting aid softwood is made after, then will
Softwood is granulated, dry, tabletting forms, and raw material is made of the component of following parts by weight:0.5 ~ 1 part of isomalto-oligosaccharide, peppermint 10 ~
20 parts, 9 ~ 11 parts of beeswax, 8 ~ 10 parts of Radix Glycyrrhizae, 20 ~ 45 parts of Loquat-Shaped Cake, sponge gourd be 0.5 ~ 1 part dry, 1 ~ 2 part of dried plum, corrigent 1.5 ~ 10
5 ~ 10 parts of part, 5 ~ 20 parts of forming agent and lubricant.
Embodiment 1
A kind of method of chewable tablets that capableing of fresh breath, includes the following steps:
(1), take the yellow plum of fresh no disease and pests harm, cleaning to dry after be cut into filament no more than 0.8mm, be put into a concentration of 3 ~ 5%
In brine impregnate 2 ~ 4h, after drying, be fried with slow fire it is micro- have focal spot, be made dried plum, it is spare;
(2), take the sponge gourd of fresh no disease and pests harm, cleaning to dry after be cut into filament no more than 0.8mm, be put into a concentration of 3 ~ 5%
2 ~ 4h is impregnated in brine, after drying, be fried with slow fire it is micro- have focal spot, it is dry to be made sponge gourd, spare;
(3), choose without the Loquat-Shaped Cake that goes mouldy, dried after removing impurity, ted after it is most probably dry and once parched completely to it;So
It will be crushed after Loquat-Shaped Cake vacuum freeze drying afterwards, cross 100 ~ 120 mesh sieve, obtain powdered Loquat-Shaped Cake;
(4), beeswax, Radix Glycyrrhizae and peppermint are distinguished into vacuum freeze drying after crush, then cross 100 ~ 120 mesh sieve, obtain powdered
Beeswax, Radix Glycyrrhizae and peppermint;
(5), take the sponge gourd of fresh no disease and pests harm, stripping and slicing after cleaning to be put into after impregnating 2 ~ 4h in a concentration of 3 ~ 5% brine and dry;
Sponge gourd block is placed in extraction kettle, is extracted using water extraction, ethanol water extraction, microwave abstracting or ultrasonic extraction technique
It takes, obtains extract liquor A;Extract liquor A is discarded into filter residue after 20 ~ 80 mesh screens, centrifugal filtration after 15 ~ 45min is stood, obtains
Extract liquor B;The concentration of extract liquor B films or reduced vacuum are concentrated into 60 ~ 65Brix, the sponge gourd water after being concentrated;By sponge gourd water
With ethyl alcohol with 12:1 volume ratio mixing, is made wetting aid, spare:
(6), according to the parts by weight of component in raw material, take 1 part of isomalto-oligosaccharide, step(1)1.5 parts of dried plum obtained, step
(2)Sponge gourd obtained does 0.5 part, step(3)35 parts of Loquat-Shaped Cake obtained, step(4)13 parts of peppermint obtained, 11 parts of beeswax and
9 parts of Radix Glycyrrhizae is uniformly mixed, and wetting aid is then added and forms softwood, the standard for adding the amount of wetting aid is:Softwood is set to hold
It is agglomerating, light pressure dissipates, and it is non-sticky to hold rear palm;Then 9 parts of 10 parts of chrysanthemum glycosides, 10 parts of gelatin and magnesium stearate is taken to be added to softwood
In, after mixing, is dried in 50 DEG C of baking oven to moisture and be down to 5% hereinafter, tabletting, is made chewable tablets finished product.
Embodiment 2
A kind of method of chewable tablets that capableing of fresh breath takes 0.5 part of isomalto-oligosaccharide, 10 parts of peppermint, 9 parts of beeswax, Radix Glycyrrhizae 8
Part, 45 parts of Loquat-Shaped Cake, sponge gourd be 0.8 part dry, 2 parts of dried plum, sorbierite part, starch slurry part and talcum powder part, wherein dried plum, sponge gourd
Dry, Loquat-Shaped Cake, peppermint, beeswax and Radix Glycyrrhizae are prepared according to the preparation method of embodiment 1;By isomalto-oligosaccharide, dried plum, silk
Melon is dry, Loquat-Shaped Cake, peppermint, beeswax and Radix Glycyrrhizae are uniformly mixed;By sponge gourd water and ethyl alcohol with 5:1 volume ratio mixing, is made wetting
Auxiliary agent;Then wetting aid is added and forms softwood, the standard for adding the amount of wetting aid is:Softwood is set to hold agglomerating, it is light to press
It dissipates, it is non-sticky to hold rear palm;Then it takes 11.2 parts of 1.5 parts of sorbierite, 20 parts of starch slurry and talcum powder to be added in softwood, mixes
After uniformly, is dried in 55 DEG C of baking oven to moisture and be down to 5% hereinafter, tabletting, is made chewable tablets finished product.
Embodiment 3
A kind of method of chewable tablets that capableing of fresh breath takes 0.6 part of isomalto-oligosaccharide, 20 parts of peppermint, 10 parts of beeswax, Radix Glycyrrhizae
8.5 parts, 20 parts of Loquat-Shaped Cake, sponge gourd be 1 part dry, 1 part of dried plum, 9.9 parts of protein sugar, 19 parts of methylcellulose and 10 parts of magnesium stearate,
Wherein, dried plum, sponge gourd be dry, Loquat-Shaped Cake, peppermint, beeswax and Radix Glycyrrhizae are prepared according to the preparation method of embodiment 1;By different malt
Oligosaccharide, dried plum, sponge gourd be dry, Loquat-Shaped Cake, peppermint, beeswax and Radix Glycyrrhizae are uniformly mixed, and sponge gourd water is then added and forms softwood, addition
The standard of the amount of sponge gourd water is:Softwood is set to hold agglomerating, light pressure dissipates, and it is non-sticky to hold rear palm;Then take protein sugar, methyl fine
Dimension element and magnesium stearate are added in softwood, after mixing, are dried in 50 DEG C of baking oven to moisture and are down to 4% hereinafter, pressure
Chewable tablets finished product is made in piece.
Comparative example 1
Using isomalto-oligosaccharide, peppermint, Radix Glycyrrhizae, corrigent, forming agent and lubricant, amount to 100 parts, wherein using water and
Ethyl alcohol forms softwood;Chewable tablets is made according to the method for embodiment 1.
Comparative example 2
Using isomalto-oligosaccharide, peppermint, Radix Glycyrrhizae, sponge gourd be dry, dried plum, corrigent, forming agent and lubricant, amounts to 100 parts,
In, softwood is formed using water and ethyl alcohol;Chewable tablets is made according to the method for embodiment 1.
Clinical trial is carried out to chewable tablets made from the present invention, comparative example 1-2, every specification 0.5g of chewable tablets often takes daily
With twice, each two panels.It chooses without the internal diseases problem such as intestines and stomach, and the patient that clinical manifestation is halitosis, even served the present invention
Chewable tablets 21 days(7 days courses for the treatment of amount to three courses for the treatment of)After observe curative effect.Patient is 90, wherein seminar(The present invention)30
Example, control group 1(Comparative example 1)30, control group 2(Comparative example 2)30, the general information ratio such as two groups of genders, age, courses of disease
Compared with no significant difference is comparable.
Using the nose diagnostic method, to 30 patients, doctor is surveyed by professional halitosis nose to diagnose, wherein odorless:Nothing after treating
Perceptible mouth odor is to eradicate;Suspicious smell:Halitosis degree reduces after treating, and has perceptible oral cavity smell preferably
Turn;Halitosis:After treatment without improve be invalid, as a result see the table below shown:
There is the case eradicated and improved in comparative example 2, be the sponge gourd because dry containing dried plum and sponge gourd in chewable tablets according to analysis
Do the complex compound generated after chewing can remove the flank of tooth, tongue fur face swill, avoid grow bacterium, and then inhibit halitosis
Generation.There is the case to improve in comparative example 1, be the fragrant factor fresh breath because of peppermint and Radix Glycyrrhizae, and have according to analysis
Play the role of it is timid fire, peppermint, record in《Chinese Pharmacopoeia》, property is pungent, cool;Return lung, Liver Channel;It function and cures mainly:Dispelling wind and heat from the body, clear profit
The head, relieving sore-throat, soothing the liver promoting the circulation of qi;Radix Glycyrrhizae first recorded in《Sheng Nong's herbal classic》, record in《Chinese Pharmacopoeia》, it is sweet in flavor, mild-natured, there is tonifying spleen
The effect of QI invigorating, clearing heat and detoxicating, expelling phlegm and arresting coughing, relieving spasm to stop pain, each all medicines of tune;Loquat-Shaped Cake is sweet in flavor sour, mild-natured;Clearing lung-heat is promoted the production of body fluid only
Yearningly.The present invention is by isomalto-oligosaccharide, dried plum, sponge gourd are dry, Loquat-Shaped Cake, peppermint, beeswax and licorice ingredient compound action, energy
It is enough effectively relieved and even eradicates the problem of bad breath caused by oral bacteria grows.
Other not described contents of the invention belong to the prior art.
Above example is in order to illustrate technical scheme of the present invention, and the purpose is to be to enable those skilled in the art
Understand present disclosure and be practiced, but is not limited the scope of the invention with this.Every reality according to the present invention
The equivalent changes or modifications that matter content is made should all cover within the scope of the present invention.
Claims (7)
1. a kind of chewable tablets for capableing of fresh breath, which is after softwood is made in raw material addition wetting aid, then will be soft
Material is granulated, dry, tabletting forms, which is characterized in that raw material is made of the component of following parts by weight:Isomalto-oligosaccharide 0.5 ~ 1
Part, 10 ~ 20 parts of peppermint, 9 ~ 11 parts of beeswax, 8 ~ 10 parts of Radix Glycyrrhizae, 20 ~ 45 parts of Loquat-Shaped Cake, sponge gourd is 0.5 ~ 1 part dry, 1 ~ 2 part of dried plum, rectifys
5 ~ 10 parts of 1.5 ~ 10 parts of taste agent, 5 ~ 20 parts of forming agent and lubricant.
2. a kind of chewable tablets for capableing of fresh breath as described in claim 1, it is characterised in that:The corrigent uses chrysanthemum
One kind in glycosides, liquiritin, protein sugar, maltitol, xylitol, lactose, sorbierite.
3. a kind of chewable tablets for capableing of fresh breath as described in claim 1, it is characterised in that:The forming agent is using shallow lake
One kind in slurry, Arabic gum, gelatin or methylcellulose.
4. a kind of chewable tablets for capableing of fresh breath as described in claim 1, it is characterised in that:The lubricant is using hard
Fatty acid magnesium or talcum powder.
5. a kind of chewable tablets for capableing of fresh breath as described in claim 1, it is characterised in that:Wetting aid is by volume ratio
10~12:0 ~ 2 sponge gourd water and ethyl alcohol composition.
6. a kind of chewable tablets for capableing of fresh breath as claimed in claim 5, it is characterised in that:Sponge gourd water uses following methods
It is prepared:The sponge gourd of fresh no disease and pests harm, stripping and slicing after cleaning is taken to be put into after impregnating 2 ~ 4h in a concentration of 3 ~ 5% brine and dry in the air
It is dry;Sponge gourd block is placed in extraction kettle and is extracted, extract liquor A is obtained;
Extract liquor A is discarded into filter residue after 20 ~ 80 mesh screens, centrifugal filtration after 15 ~ 45min is stood, obtains extract liquor B;It will
Extract liquor B films concentrate or reduced vacuum is concentrated into 60 ~ 65Brix, the sponge gourd water after being concentrated.
7. preparing a kind of method of chewable tablets that capableing of fresh breath as described in claim 1, which is characterized in that including following
Step:
(1), take the yellow plum of fresh no disease and pests harm, cleaning to dry after chop up silk, be put into 2 ~ 4h of immersion in a concentration of 3 ~ 5% brine,
After drying, be fried with slow fire it is micro- have focal spot, be made dried plum, it is spare;
(2), take the sponge gourd of fresh no disease and pests harm, cleaning to dry after chop up silk, be put into 2 ~ 4h of immersion in a concentration of 3 ~ 5% brine,
After drying, be fried with slow fire it is micro- have focal spot, it is dry to be made sponge gourd, spare;
(3), choose without the Loquat-Shaped Cake that goes mouldy, dried after removing impurity, ted after it is most probably dry and once parched completely to it;So
It will be crushed after Loquat-Shaped Cake vacuum freeze drying afterwards, cross 100 ~ 120 mesh sieve, obtain powdered Loquat-Shaped Cake;
(4), beeswax, Radix Glycyrrhizae and peppermint are distinguished into vacuum freeze drying after crush, then cross 100 ~ 120 mesh sieve, obtain powdered
Beeswax, Radix Glycyrrhizae and peppermint;
(5), according to the parts by weight of component in the raw material of claim 1, take 0.5 ~ 1 part of isomalto-oligosaccharide, step(1)It is obtained
Dried plum, step(2)Sponge gourd obtained is dry, step(3)Loquat-Shaped Cake obtained, step(4)Peppermint, beeswax and Radix Glycyrrhizae obtained mix
It closes uniformly, wetting aid is then added and forms softwood, the standard for adding the amount of wetting aid is:Softwood is set to hold agglomerating, gently
Pressure dissipates, and it is non-sticky to hold rear palm;
(6), according to the parts by weight of component in the raw material of claim 1, take corrigent, forming agent and lubricant to be added to softwood
In, after mixing, is dried in 50 ~ 55 DEG C of baking oven to moisture and be down to 5% hereinafter, tabletting, is made chewable tablets finished product.
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