CN110075044A - A kind of Chinese medicine mouth wash and preparation method thereof with bacteriostasis - Google Patents
A kind of Chinese medicine mouth wash and preparation method thereof with bacteriostasis Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/11—Pteridophyta or Filicophyta (ferns)
- A61K36/12—Filicopsida or Pteridopsida
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/287—Chrysanthemum, e.g. daisy
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/758—Zanthoxylum, e.g. pricklyash
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/89—Cyperaceae (Sedge family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/02—Local antiseptics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
Abstract
The present invention discloses a kind of Chinese medicine mouth wash and preparation method thereof with bacteriostasis, the present invention is using Sweet tea, water chestnut skin, Radix zanthoxyli, Semi-pinnated Brake Herb, mother chrysanthemum, Huashan alum as raw material, by being extracted to chinese medicine material, obtain extracting solution, then each extracting solution is mixed, and peppermint oil, glycerol and water is added, it is uniformly mixed to get the Chinese medicine mouth wash with bacteriostasis.Mouthwash of the invention has the function of heat-clearing, anti-inflammatory, antibacterial, nonirritant, can effectively inhibit oral bacteria, remove removing abnormal flavor in oral cavity, with the effect of good cleaning-nursing oral cavity, and abundant raw material, it is easy to get, it is at low cost, preparation method is simple, is suitble to industrialized production.
Description
Technical field
The invention belongs to medicine, daily chemical product technical field, and in particular to a kind of Chinese medicine mouth wash with bacteriostasis.
Background technique
Oral health is closely bound up with health, and mouth disease is mostly all related with bacterium, such as saprodontia and canker sore.
Saprodontia is bacteriosis, and due to oral cavity ecological disturbance, normal bacteria becomes conditioned pathogen and causes, it can be with secondary dental pulp
Scorching and periapical inflammation, or even alveolar bone and inflammation of jaws can be caused etc., lead to the whole destructions for suffering from tooth；The secondary infection of saprodontia can
To form lesion, bacteriotoxin borrows blood circulation to expand to whole body, induces systemic disease.Canker sore is a kind of more typical
Transmucosal disease, mostly bacterium or virus infection cause, and disease incidence is high and easily recurs, and when morbidity has severe pain to feel, shadow
It rings feed and speaks, bring huge pain and inconvenient to patient, the pain increased when especially meeting vinegar-pepper food.
Routine, which is brushed teeth, is merely able to remove the bacterial plaque of facing part, substantially incompetent for the bacterial plaque for removing oral soft tissue surfaces
For power.And mouthwash can deep each position of human mouth, be a kind of auxiliary well between gingival edge and teeth space including the contact of toothbrush difficulty
Help control bacterial plaque measure.Mouthwash is easy to carry using simple, is the old man of loss of tooth, the child that will not be brushed teeth and not
The optimal selection for the dental patient's oral hygiene guarantee brushed teeth can be endured.Meanwhile mouthwash also has very big social effect, it
It can make people's oral cavity fresh and cool after use, increase confidence, show glamour.
The ingredients such as metronidazole or hydrogen peroxide are added in antibacterial mouthwash currently on the market mostly, but are gargled using metronidazole
Water changes there are the sense of taste and the adverse reactions such as oral mucosa shouting pain, Nausea and vomiting, and hydrogen peroxide, which is used for a long time, can produce facing decalcification
With the side effects such as black hairy tongue, therefore, Chinese medicine mouth wash is increasingly had been favored by people, however due to Chinese medicine mouth wash exist it is former
Expect various, the problems such as raw material is not easy to obtain, and cost of material is high, and extract preparation process is complicated, and fungistatic effect is undesirable, is not easy to answer
For industrial production.
Summary of the invention
In view of the above problems, the present invention provides a kind of Chinese medicine mouth wash and preparation method thereof with bacteriostasis, this hair
Bright to prepare a kind of good antimicrobial effect using Sweet tea, water chestnut skin, Radix zanthoxyli, Semi-pinnated Brake Herb, mother chrysanthemum, Huashan alum as raw material, safety is made without pair
With Chinese medicine mouth wash at low cost.
The invention is realized by the following technical scheme:
A kind of Chinese medicine mouth wash with bacteriostasis, raw material components and weight percent are as follows: 5-50 parts of Sweet tea, water chestnut
5-20 parts of skin, 1-10 parts of Radix zanthoxyli, 3-40 parts of Semi-pinnated Brake Herb, 1-10 parts of mother chrysanthemum, alum 1-100 parts of the Huashan.
As a preferred option of the technical scheme, raw material components and weight percent are as follows: 20-30 parts of Sweet tea, water chestnut skin 10-15
Part, 3-7 parts of Radix zanthoxyli, 20-25 parts of Semi-pinnated Brake Herb, 3-7 parts of mother chrysanthemum, alum 50-60 parts of the Huashan.
As the further preferred of technical solution, raw material components and weight percent are as follows: 25 parts of Sweet tea, water chestnut skin 13
Part, 5 parts of Radix zanthoxyli, 22 parts of Semi-pinnated Brake Herb, 5 parts of mother chrysanthemum, 55 parts of Huashan alum.
A kind of preparation method of the Chinese medicine mouth wash with bacteriostasis, includes the following steps,
(1) Sweet tea, water chestnut skin, Radix zanthoxyli, Semi-pinnated Brake Herb, Huashan alum and mother chrysanthemum the processing of raw material: are removed into impurity and mildew
Part, Sweet tea, water chestnut skin, Radix zanthoxyli, Semi-pinnated Brake Herb and Huashan alum flour is broken, sieving is better than weighing according to raw material weight, spare；
(2) extraction of Sweet tea and water chestnut skin: taking Sweet tea powder and water chestnut skin powder, is separately added into ethyl alcohol, impregnates 1-2h, so
Ultrasonic extraction 2-3 times afterwards, each 1-2h, filtering, merging filtrate obtain mixed liquor I and mixed liquor I ', by mixed liquor I and mixing
Liquid I ' depressurizes boil off ethyl alcohol respectively, obtains Sweet tea extracting solution and water chestnut skin extracting solution；
(3) it the extraction of Huashan alum: takes Huashan alum flour last, ethyl alcohol is added, impregnate 1-2h, be then refluxed for extraction 2-3 times, every time
1-2h, filtering, merging filtrate obtain mixed liquor II, and the decompression of mixed liquor II is boiled off ethyl alcohol, obtains Huashan alum extracting solution；
(4) extraction of Semi-pinnated Brake Herb: taking Semi-pinnated Brake Herb powder, and ethyl alcohol is added, and impregnates 1-2h, is then refluxed for extraction 2-3 times, every time
1-2h, filtering, merging filtrate obtain mixed liquor III, and the decompression of mixed liquor III is boiled off ethyl alcohol, obtains Semi-pinnated Brake Herb extracting solution；
(5) extraction of Radix zanthoxyli: taking Radix zanthoxyli powder, and ethyl alcohol is added, and impregnates 30-40min, then ultrasonic extraction 2-3 times,
Each 30-60min, filtering, merging filtrate obtain mixed liquor IV, and the decompression of mixed liquor IV is boiled off ethyl alcohol, obtains Radix zanthoxyli extraction
Liquid；
(6) extraction of mother chrysanthemum: taking mother chrysanthemum, add water to cook 2-3 times, and decoction liquor is mixed, obtains mixed liquor by each 1-2h
V, mixed liquor V is concentrated under reduced pressure into medicinal extract, mother chrysanthemum medicinal extract is obtained；
(7) preparation of Chinese medicine mouth wash: Sweet tea extracting solution, water chestnut skin extracting solution, Huashan alum extracting solution, Semi-pinnated Brake Herb are extracted
Liquid, Radix zanthoxyli extracting solution, mother chrysanthemum medicinal extract are mixed, and peppermint oil, glycerol and water is added, and are uniformly mixed to get with antibacterial
The Chinese medicine mouth wash of effect.
As a preferred option of the technical scheme, the concentration of the ethyl alcohol is 40-80%.
As a preferred option of the technical scheme, temperature setting when decompression boils off ethyl alcohol is 60-65 DEG C.
As a preferred option of the technical scheme, in step (6), the additional amount of water is 6-8 times of solid matter, and additional amount is for the first time
8 times of solid matter, are then gradually reduced.
As a preferred option of the technical scheme, in step (6), mixed liquor V is concentrated under reduced pressure at 60-68 DEG C into medicinal extract.
As a preferred option of the technical scheme, the Sweet tea extracting solution, water chestnut skin extracting solution, Huashan alum extracting solution, Semi-pinnated Brake Herb mention
Taking the concentration of liquid and Radix zanthoxyli extracting solution is 1g/ml；The 1g decoction of the mother chrysanthemum medicinal extract is equivalent to 1g crude drug.
As a preferred option of the technical scheme, Sweet tea extracting solution, water chestnut skin extracting solution, Huashan alum extracting solution, Semi-pinnated Brake Herb are extracted
Liquid, Radix zanthoxyli extracting solution, mother chrysanthemum medicinal extract carry out being mixed to get 50-80 parts of mixed liquor according to weight ratio 3:1:2.5:1.5:1:0.5,
And 5-20 portions of peppermint oils, 5-20 parts of glycerol and 300-600 water is added, it is uniformly mixed and gargles to get the Chinese medicine with bacteriostasis
Water.
As a preferred option of the technical scheme, 0.05-0.1 portions of preservatives, 0.5-0.8 parts of essence are additionally added in the step (7).
Preservative and essence select existing product, allow to be added to the preservative and essence of mouthwash, as preservative selects thyme
Phenol, glycyrrhizic acid, potassium sorbate etc., essence select Mint Essence, wrinkled giant hyssop essence, osmanthus flower fragrance etc..
The effect of chinese medicine material of the invention:
The dried leaf of Sweet tea system rosaceous plant sweetness agent classification Rubus suavissimus S.Lee, is that Guangxi is peculiar
Nontoxic, low in calories, high sugariness and wild rare sweet-tasting plant with health care function.Yao nationality medicine effect: clearing heat and detoxicating, diuresis disappears
It is swollen, dispelling wind of invigorating blood circulation, clearing lung-heat, help, convergence, analgesic.(cold, fever and cough) is breathed out for breathing out wheel anger, many (children of paddy Ah Beng cassie
Indigestion), cloth is waken up water spinach (nephritic dropsy), is also changed and is hidden logical (stool, urine is obstructed), and sample thinkling sound is sick (high blood pressure), winter smooth (glycosuria
Disease), Jiu Gang Han (gastroenteritis), collapses and close bored (rheumatalgia, rheumatoid arthritis), more larynx bored (abscess of throat) and pupil name pyogenic infections
(ulcerative carbuncle pyogenic infections).The main component of Sweet tea is rubusoside, is a kind of natural sweetener, and sugariness is 15 times of sucrose, safety, nothing
Poison, heat is low, will not saprodontia, not will increase cholesterol level, there is antibacterial, antiallergy is antitumor, and the pharmacology such as hypoglycemic are made
With food additives being now widely used in, in health food.
Water chestnut skin system's Cyperaceae plants the bulb crust of water chestnut Heleocharis dulcis (Burm.f.) Trin., alias horse
Hoof, black taro, is distributed mainly on Guangxi.The main component of water chestnut skin is puchiin, to staphylococcus aureus, Escherichia coli and green
Purulence bacillus all has certain inhibiting effect, cures mainly consumption of body fluid caused by febrile disease polydipsia, abscess of throat, stomatitis, jaundice with damp-heat pathogen, hypertension
Disease, difficult urination, morbilli, cough with lung heat, hemorrhoid hemorrhage.Strong doctor: sweet tea, cool；Bulb tune anus, water channel, air flue, heat-clearing poison, are used
In goods cigarette mother (pharyngalgia), aphtha (canker sore), acute conjunctivitis (acute conjunctivitis), meat turn round (stranguria), and lung heat is run quickly cough (cough), eastern youth
(food stagnation), the swelling and pain of Rusty Nail incarnation；Stalk turns round (stranguria) for meat.
Radix zanthoxyli be rutaceae Radix zanthoxyli Zanthoxylum nitidum (Roxb.) DC. dry root, record in
The Guangxi Zhuang medicine quality standard first volume.Chinese medicine: it is bitter, it is pungent, it puts down；It is slightly poisonous.Return liver, stomach meridian.Promoting qi circulation and relieving pain, activating microcirculation and removing stasis medicinal, wind-dispelling
Dredging collateral, for injury from falling down, rheumatic arthralgia, stomachache, toothache caused by qi depression to blood stasis, venomous snake bite；The burning hot wound of soup is controlled outside.It is strong
Doctor: bitter, peppery, heat；It is slightly poisonous.Tong Longlu fire road, wind-dispelling poison, heat-clearing poison, swelling and pain relieving.For sending out prosperous (treating rheumatic ostealgia), pain in the loins,
Slave (scrofula), poor acute diseases such as cholera and sunstroke (flu), toothache, goods cigarette mother (abscess of throat) are seeped shelves phase (burn and scald), and hernia, (poisonous snake stings E Ha
Wound).
Semi-pinnated Brake Herb is the drying herb of Pteridaceae plant Semi-pinnated Brake Herb Pteris semipinnata Linn..Chinese medicine: bitter,
It is pungent, it is cool.Return liver, large intestine channel.Clearing heat and promoting diuresis, cooling blood and hemostasis, removing toxicity for detumescence.For diarrhea, dysentery, jaundice, red eye, swell pain, tooth
Bitterly, it spits blood, hemorrhoid hemorrhage, traumatic hemorrhage, traumatic injury, pruitus, venomous snake bite.Strong doctor: bitter, peppery, cool.Heat-clearing poison, is removed
Wet poison dissipates the stasis of blood and swells, adjusts anus.For A Yimi (dysentery), can freshwater mussel (jaundice), acute conjunctivitis (acute conjunctivitis), promise howl rattles away (dental pulp
Scorching, periodontitis), infiltration is split (haematemesiss), and secondary he Ben Yin's (hemorrhoid), woods must sting phase (traumatic injury), and wheat is rough (rubeola), E Ha (poisonous snake
It bites).
Mother chrysanthemum is the inflorescence of composite family herbaceos perennial mother chrysanthemum Chrysanthemum indicum (L.) Des Moul..
Strong doctor: it is bitter, it is micro- peppery, it is cool.The road Tiao Long, fiery road, heat-clearing poison, wind-dispelling poison remove wet poison.For poor acute diseases such as cholera and sunstroke (flu), acute conjunctivitis (acute conjunctiva
It is scorching), aphtha (canker sore), the symptoms such as skilful Yin's (headache).
Huashan alum is the complete stool of the Symplocaceae mountain alum platymiscium Huashan alum Symplocos chinensis (Lour.) Druce,
Leaf, fruit, root can be used as medicine, have it is clearing heat and detoxicating, remove obstruction in channels to relieve pain, sore furuncle, traumatic injury, hemostasia and promoting granulation, resolving sputum dampness removing etc.
Effect, for treat the burning hot wound of sore swollen toxin, wound hemorrhage, soup, ulcer rotten sore, cold, fever, arthralgia and myalgia, restlessness and thirst,
Acute nephritis, malaria, dysentery, enteritis, mad dog and venomous snake bite etc., be distributed mainly on Zhejiang, Fujian, Taiwan, Anhui, Jiangxi,
The provinces and regions such as Hunan, Guangdong, Guangxi, Yunnan, Guizhou, Sichuan.Huashan alum alias: native Changshan, drop phlegm king, tribute wingceltis pocket, nail glutinous rehmannia
(" Illustrated Book on Plants "), Chinese eurya root wood, rice son spend (" Nanning City's drug will "), bubble wood, glutinous rice tree, hemostasis tree (" Guangxi
Chinese medicinal herbal "), bullshit wooden (" Guangxi Chinese herbal medicine "), China grey wood, Newt wood, Thunder God needle, swollen medicine, Plumbago zeylanica, seven needles, colour of loess bavin
(" plant of Guangxi Chinese veterinarian's medicine ") etc..
Compared with prior art, the invention has the benefit that
(1) Sweet tea, water chestnut skin, Radix zanthoxyli, Semi-pinnated Brake Herb, mother chrysanthemum and Huashan alum extract are added in mouthwash of the invention
Traditional Chinese medicine ingredients, Sweet tea and water chestnut skin all have Antibacterial Constituents, have good antibacterial action, Radix zanthoxyli, Semi-pinnated Brake Herb, mother chrysanthemum
The addition of clearing heat and detoxicating, swelling and pain relieving, especially Semi-pinnated Brake Herb and Huashan alum enhances the heat clearing and inflammation relieving of mouthwash with Huashan alum
Effect, can effectively inhibit bacteria breed, enhance the bacteriostasis of mouthwash；Each traditional Chinese medicinal components synergistic effect in mouthwash, so that
It has the function of heat-clearing, anti-inflammatory, antibacterial, can effectively inhibit oral bacteria, remove removing abnormal flavor in oral cavity, have good cleaning-nursing
Oral cavity effect.
(2) good antimicrobial effect of Chinese medicine mouth wash of the invention, when preparation, can not add preservative or only need to add
A small amount of preservative, conventional preservative dosage are the 1-3% of mouthwash gross weight, and preservative dosage of the invention is total lower than mouthwash
The 0.03% of weight, preservative dosage is few, and anti-corrosion effect is suitable, and product is more green safe.
(3) when Chinese medicine raw material components and weight percent are 25 parts of Sweet tea, 13 parts of water chestnut skin, 5 parts of Radix zanthoxyli, Semi-pinnated Brake Herb 22
When part, 5 parts of mother chrysanthemum, 55 parts of Huashan alum, the bacteriostasis of Chinese medicine mouth wash obtained is best, to Escherichia coli bacteriostasis rate, to gold
Staphylococcus aureus bacteriostasis rate and 99.5% or more is reached to Candida albicans bacteriostasis rate.
(4) Chinese medicine material Sweet tea of the invention, water chestnut skin, Radix zanthoxyli, Semi-pinnated Brake Herb, mother chrysanthemum and Huashan alum, abundant raw material, easily
, it is at low cost, and preparation method is simple, is suitble to industrialized production.
Specific embodiment
Below in conjunction with specific embodiment, the present invention is described in more detail, but is not limited to protection scope of the present invention.
Embodiment 1
A kind of Chinese medicine mouth wash with bacteriostasis, raw material components and weight percent are as follows: 25 parts of Sweet tea, water chestnut skin
13 parts, 5 parts of Radix zanthoxyli, 22 parts of Semi-pinnated Brake Herb, 5 parts of mother chrysanthemum, 55 parts of Huashan alum.
Preparation method includes the following steps,
(1) Sweet tea, water chestnut skin, Radix zanthoxyli, Semi-pinnated Brake Herb, Huashan alum and mother chrysanthemum the processing of raw material: are removed into impurity and mildew
Part, Sweet tea, water chestnut skin, Radix zanthoxyli, Semi-pinnated Brake Herb and Huashan alum flour is broken, sieving is better than weighing according to raw material weight, spare；
(2) extraction of Sweet tea and water chestnut skin: taking Sweet tea powder and water chestnut skin powder, is separately added into the second that concentration is 60%
Alcohol impregnates 2h, then ultrasonic extraction 3 times, and each 1h is filtered, and merging filtrate obtains mixed liquor I and mixed liquor I ', by mixed liquor
I and mixed liquor I ' boil off ethyl alcohol in 62 DEG C of decompressions respectively, obtain concentration be 1g/ml Sweet tea extracting solution and water chestnut skin extracting solution；
(3) extraction of Huashan alum: taking Huashan alum flour last, and the ethyl alcohol that concentration is 80% is added, and impregnates 2h, is then refluxed for extracting
3 times, each 1h, filtering, merging filtrate obtains mixed liquor II, mixed liquor II is boiled off ethyl alcohol in 62 DEG C of decompressions, obtaining concentration is
The Huashan alum extracting solution of 1g/ml；
(4) extraction of Semi-pinnated Brake Herb: taking Semi-pinnated Brake Herb powder, and the ethyl alcohol that concentration is 80% is added, and impregnates 2h, is then refluxed for extracting
3 times, each 1h, filtering, merging filtrate obtains mixed liquor III, mixed liquor III is boiled off ethyl alcohol in 62 DEG C of decompressions, obtaining concentration is
The Semi-pinnated Brake Herb extracting solution of 1g/ml；
(5) extraction of Radix zanthoxyli: taking Radix zanthoxyli powder, and the ethyl alcohol that concentration is 40% is added, and impregnates 40min, then ultrasonic
It extracts 3 times, each 30min, filtering, merging filtrate obtains mixed liquor IV, mixed liquor IV is boiled off ethyl alcohol in 62 DEG C of decompressions, is obtained
The Radix zanthoxyli extracting solution for being 1g/ml to concentration；
(6) extraction of mother chrysanthemum: taking mother chrysanthemum, adds water to cook 3 times, and the additional amount of water is 6-8 times of solid matter, is added for the first time
Amount is 8 times of solid matter, is then gradually reduced, each 1h mixes decoction liquor, obtains mixed liquor V, and mixed liquor V is existed
It is concentrated under reduced pressure at 65 DEG C into medicinal extract, obtains the mother chrysanthemum medicinal extract that 1g decoction is equivalent to 1g crude drug；
(7) preparation of Chinese medicine mouth wash: Sweet tea extracting solution, water chestnut skin extracting solution, Huashan alum extracting solution, Semi-pinnated Brake Herb are extracted
Liquid, Radix zanthoxyli extracting solution, mother chrysanthemum medicinal extract be mixed to get 70 parts of mixed liquor according to weight ratio 3:1:2.5:1.5:1:0.5, and
12 portions of peppermint oils, 13 parts of glycerol, 0.05 portion of preservative, 0.7 part of essence and 450 parts of water are added, are uniformly mixed to get with antibacterial
The Chinese medicine mouth wash of effect.
Embodiment 2
A kind of Chinese medicine mouth wash with bacteriostasis, raw material components and weight percent are as follows: 30 parts of Sweet tea, water chestnut skin
10 parts, 3 parts of Radix zanthoxyli, 25 parts of Semi-pinnated Brake Herb, 3 parts of mother chrysanthemum, 60 parts of Huashan alum.
Preparation method includes the following steps,
(1) Sweet tea, water chestnut skin, Radix zanthoxyli, Semi-pinnated Brake Herb, Huashan alum and mother chrysanthemum the processing of raw material: are removed into impurity and mildew
Part, Sweet tea, water chestnut skin, Radix zanthoxyli, Semi-pinnated Brake Herb and Huashan alum flour is broken, sieving is better than weighing according to raw material weight, spare；
(2) extraction of Sweet tea and water chestnut skin: taking Sweet tea powder and water chestnut skin powder, is separately added into the second that concentration is 60%
Alcohol impregnates 2h, then ultrasonic extraction 3 times, and each 1h is filtered, and merging filtrate obtains mixed liquor I and mixed liquor I ', by mixed liquor
I and mixed liquor I ' boil off ethyl alcohol in 63 DEG C of decompressions respectively, obtain concentration be 1g/ml Sweet tea extracting solution and water chestnut skin extracting solution；
(3) extraction of Huashan alum: taking Huashan alum flour last, and the ethyl alcohol that concentration is 60% is added, and impregnates 2h, is then refluxed for extracting
3 times, each 1h, filtering, merging filtrate obtains mixed liquor II, mixed liquor II is boiled off ethyl alcohol in 63 DEG C of decompressions, obtaining concentration is
The Huashan alum extracting solution of 1g/ml；
(4) extraction of Semi-pinnated Brake Herb: taking Semi-pinnated Brake Herb powder, and the ethyl alcohol that concentration is 60% is added, and impregnates 2h, is then refluxed for extracting
3 times, each 1h, filtering, merging filtrate obtains mixed liquor III, mixed liquor III is boiled off ethyl alcohol in 63 DEG C of decompressions, obtaining concentration is
The Semi-pinnated Brake Herb extracting solution of 1g/ml；
(5) extraction of Radix zanthoxyli: taking Radix zanthoxyli powder, and the ethyl alcohol that concentration is 60% is added, and impregnates 40min, then ultrasonic
It extracts 3 times, each 30min, filtering, merging filtrate obtains mixed liquor IV, mixed liquor IV is boiled off ethyl alcohol in 63 DEG C of decompressions, is obtained
The Radix zanthoxyli extracting solution for being 1g/ml to concentration；
(6) extraction of mother chrysanthemum: taking mother chrysanthemum, adds water to cook 3 times, and the additional amount of water is 6-8 times of solid matter, is added for the first time
Amount is 8 times of solid matter, is then gradually reduced, each 2h mixes decoction liquor, obtains mixed liquor V, and mixed liquor V is existed
It is concentrated under reduced pressure at 65 DEG C into medicinal extract, obtains the mother chrysanthemum medicinal extract that 1g decoction is equivalent to 1g crude drug；
(7) preparation of Chinese medicine mouth wash: Sweet tea extracting solution, water chestnut skin extracting solution, Huashan alum extracting solution, Semi-pinnated Brake Herb are extracted
Liquid, Radix zanthoxyli extracting solution, mother chrysanthemum medicinal extract be mixed to get 60 parts of mixed liquor according to weight ratio 3:1:2.5:1.5:1:0.5, and
15 portions of peppermint oils, 15 parts of glycerol, 0.06 portion of preservative, 0.7 part of essence and 400 parts of water are added, are uniformly mixed to get with antibacterial
The Chinese medicine mouth wash of effect.
Embodiment 3
A kind of Chinese medicine mouth wash with bacteriostasis, raw material components and weight percent are as follows: 20 parts of Sweet tea, water chestnut skin
15 parts, 7 parts of Radix zanthoxyli, 20 parts of Semi-pinnated Brake Herb, 7 parts of mother chrysanthemum, 50 parts of Huashan alum.
Preparation method includes the following steps,
(1) Sweet tea, water chestnut skin, Radix zanthoxyli, Semi-pinnated Brake Herb, Huashan alum and mother chrysanthemum the processing of raw material: are removed into impurity and mildew
Part, Sweet tea, water chestnut skin, Radix zanthoxyli, Semi-pinnated Brake Herb and Huashan alum flour is broken, sieving is better than weighing according to raw material weight, spare；
(2) extraction of Sweet tea and water chestnut skin: taking Sweet tea powder and water chestnut skin powder, is separately added into the second that concentration is 50%
Alcohol impregnates 1.5h, then ultrasonic extraction 3 times, and each 1h is filtered, and merging filtrate obtains mixed liquor I and mixed liquor I ', will mix
Liquid I and mixed liquor I ' boil off ethyl alcohol in 63 DEG C of decompressions respectively, obtain the Sweet tea extracting solution and the extraction of water chestnut skin that concentration is 1g/ml
Liquid；
(3) extraction of Huashan alum: taking Huashan alum flour last, and the ethyl alcohol that concentration is 75% is added, and impregnates 1.5h, is then refluxed for mentioning
It takes 3 times, each 1h, filters, merging filtrate obtains mixed liquor II, mixed liquor II is boiled off ethyl alcohol in 63 DEG C of decompressions, obtains concentration
For the Huashan alum extracting solution of 1g/ml；
(4) extraction of Semi-pinnated Brake Herb: taking Semi-pinnated Brake Herb powder, and the ethyl alcohol that concentration is 75% is added, and impregnates 1.5h, is then refluxed for mentioning
It takes 3 times, each 1h, filters, merging filtrate obtains mixed liquor III, mixed liquor III is boiled off ethyl alcohol in 63 DEG C of decompressions, obtains concentration
For the Semi-pinnated Brake Herb extracting solution of 1g/ml；
(5) extraction of Radix zanthoxyli: taking Radix zanthoxyli powder, and the ethyl alcohol that concentration is 50% is added, and impregnates 35min, then ultrasonic
It extracts 3 times, each 40min, filtering, merging filtrate obtains mixed liquor IV, mixed liquor IV is boiled off ethyl alcohol in 63 DEG C of decompressions, is obtained
The Radix zanthoxyli extracting solution for being 1g/ml to concentration；
(6) extraction of mother chrysanthemum: taking mother chrysanthemum, adds water to cook 3 times, and the additional amount of water is 6-8 times of solid matter, is added for the first time
Amount is 8 times of solid matter, is then gradually reduced, each 1.5h mixes decoction liquor, mixed liquor V is obtained, by mixed liquor V
It is concentrated under reduced pressure at 65 DEG C into medicinal extract, obtains the mother chrysanthemum medicinal extract that 1g decoction is equivalent to 1g crude drug；
(7) preparation of Chinese medicine mouth wash: Sweet tea extracting solution, water chestnut skin extracting solution, Huashan alum extracting solution, Semi-pinnated Brake Herb are extracted
Liquid, Radix zanthoxyli extracting solution, mother chrysanthemum medicinal extract be mixed to get 75 parts of mixed liquor according to weight ratio 3:1:2.5:1.5:1:0.5, and
10 portions of peppermint oils, 10 parts of glycerol, 0.07 portion of preservative, 0.6 part of essence and 500 parts of water are added, are uniformly mixed to get with antibacterial
The Chinese medicine mouth wash of effect.
Embodiment 4
A kind of Chinese medicine mouth wash with bacteriostasis, raw material components and weight percent are as follows: 10 parts of Sweet tea, water chestnut skin
10 parts, 2 parts of Radix zanthoxyli, 40 parts of Semi-pinnated Brake Herb, 1 part of mother chrysanthemum, 30 parts of Huashan alum.
Preparation method includes the following steps,
(1) Sweet tea, water chestnut skin, Radix zanthoxyli, Semi-pinnated Brake Herb, Huashan alum and mother chrysanthemum the processing of raw material: are removed into impurity and mildew
Part, Sweet tea, water chestnut skin, Radix zanthoxyli, Semi-pinnated Brake Herb and Huashan alum flour is broken, sieving is better than weighing according to raw material weight, spare；
(2) extraction of Sweet tea and water chestnut skin: taking Sweet tea powder and water chestnut skin powder, is separately added into the second that concentration is 80%
Alcohol impregnates 1.5h, then ultrasonic extraction 3 times, and each 1h is filtered, and merging filtrate obtains mixed liquor I and mixed liquor I ', will mix
Liquid I and mixed liquor I ' boil off ethyl alcohol in 62 DEG C of decompressions respectively, obtain the Sweet tea extracting solution and the extraction of water chestnut skin that concentration is 1g/ml
Liquid；
(3) extraction of Huashan alum: taking Huashan alum flour last, and the ethyl alcohol that concentration is 60% is added, and impregnates 1.5h, is then refluxed for mentioning
It takes 3 times, each 1h, filters, merging filtrate obtains mixed liquor II, mixed liquor II is boiled off ethyl alcohol in 62 DEG C of decompressions, obtains concentration
For the Huashan alum extracting solution of 1g/ml；
(4) extraction of Semi-pinnated Brake Herb: taking Semi-pinnated Brake Herb powder, and the ethyl alcohol that concentration is 60% is added, and impregnates 1.5h, is then refluxed for mentioning
It takes 3 times, each 1h, filters, merging filtrate obtains mixed liquor III, mixed liquor III is boiled off ethyl alcohol in 62 DEG C of decompressions, obtains concentration
For the Semi-pinnated Brake Herb extracting solution of 1g/ml；
(5) extraction of Radix zanthoxyli: taking Radix zanthoxyli powder, and the ethyl alcohol that concentration is 80% is added, and impregnates 35min, then ultrasonic
It extracts 3 times, each 50min, filtering, merging filtrate obtains mixed liquor IV, mixed liquor IV is boiled off ethyl alcohol in 62 DEG C of decompressions, is obtained
The Radix zanthoxyli extracting solution for being 1g/ml to concentration；
(6) extraction of mother chrysanthemum: taking mother chrysanthemum, adds water to cook 3 times, and the additional amount of water is 6-8 times of solid matter, is added for the first time
Amount is 8 times of solid matter, is then gradually reduced, each 1.5h mixes decoction liquor, mixed liquor V is obtained, by mixed liquor V
It is concentrated under reduced pressure at 63 DEG C into medicinal extract, obtains the mother chrysanthemum medicinal extract that 1g decoction is equivalent to 1g crude drug；
(7) preparation of Chinese medicine mouth wash: Sweet tea extracting solution, water chestnut skin extracting solution, Huashan alum extracting solution, Semi-pinnated Brake Herb are extracted
Liquid, Radix zanthoxyli extracting solution, mother chrysanthemum medicinal extract be mixed to get 65 parts of mixed liquor according to weight ratio 3:1:2.5:1.5:1:0.5, and
18 portions of peppermint oils, 6 parts of glycerol, 0.08 portion of preservative, 0.6 part of essence and 400 parts of water are added, are uniformly mixed to get with antibacterial
The Chinese medicine mouth wash of effect.
Embodiment 5
A kind of Chinese medicine mouth wash with bacteriostasis, raw material components and weight percent are as follows: 50 parts of Sweet tea, water chestnut skin
5 parts, 3 parts of Radix zanthoxyli, 5 parts of Semi-pinnated Brake Herb, 10 parts of mother chrysanthemum, 10 parts of Huashan alum.
Preparation method includes the following steps,
(1) Sweet tea, water chestnut skin, Radix zanthoxyli, Semi-pinnated Brake Herb, Huashan alum and mother chrysanthemum the processing of raw material: are removed into impurity and mildew
Part, Sweet tea, water chestnut skin, Radix zanthoxyli, Semi-pinnated Brake Herb and Huashan alum flour is broken, sieving is better than weighing according to raw material weight, spare；
(2) extraction of Sweet tea and water chestnut skin: taking Sweet tea powder and water chestnut skin powder, is separately added into the second that concentration is 60%
Alcohol impregnates 1h, then ultrasonic extraction 2 times, and each 2h is filtered, and merging filtrate obtains mixed liquor I and mixed liquor I ', by mixed liquor
I and mixed liquor I ' boil off ethyl alcohol in 61 DEG C of decompressions respectively, obtain concentration be 1g/ml Sweet tea extracting solution and water chestnut skin extracting solution；
(3) extraction of Huashan alum: taking Huashan alum flour last, and the ethyl alcohol that concentration is 80% is added, and impregnates 1h, is then refluxed for extracting
2 times, each 2h, filtering, merging filtrate obtains mixed liquor II, mixed liquor II is boiled off ethyl alcohol in 61 DEG C of decompressions, obtaining concentration is
The Huashan alum extracting solution of 1g/ml；
(4) extraction of Semi-pinnated Brake Herb: taking Semi-pinnated Brake Herb powder, and the ethyl alcohol that concentration is 80% is added, and impregnates 1h, is then refluxed for extracting
2 times, each 2h, filtering, merging filtrate obtains mixed liquor III, mixed liquor III is boiled off ethyl alcohol in 61 DEG C of decompressions, obtaining concentration is
The Semi-pinnated Brake Herb extracting solution of 1g/ml；
(5) extraction of Radix zanthoxyli: taking Radix zanthoxyli powder, and the ethyl alcohol that concentration is 40% is added, and impregnates 30min, then ultrasonic
It extracts 2 times, each 60min, filtering, merging filtrate obtains mixed liquor IV, mixed liquor IV is boiled off ethyl alcohol in 61 DEG C of decompressions, is obtained
The Radix zanthoxyli extracting solution for being 1g/ml to concentration；
(6) extraction of mother chrysanthemum: taking mother chrysanthemum, adds water to cook 2 times, and the additional amount of water is 6-8 times of solid matter, is added for the first time
Amount is 8 times of solid matter, is then gradually reduced, each 2h mixes decoction liquor, obtains mixed liquor V, and mixed liquor V is existed
It is concentrated under reduced pressure at 62 DEG C into medicinal extract, obtains the mother chrysanthemum medicinal extract that 1g decoction is equivalent to 1g crude drug；
(7) preparation of Chinese medicine mouth wash: Sweet tea extracting solution, water chestnut skin extracting solution, Huashan alum extracting solution, Semi-pinnated Brake Herb are extracted
Liquid, Radix zanthoxyli extracting solution, mother chrysanthemum medicinal extract be mixed to get 60 parts of mixed liquor according to weight ratio 3:1:2.5:1.5:1:0.5, and
20 portions of peppermint oils, 5 parts of glycerol, 0.09 portion of preservative, 0.8 part of essence and 450 parts of water are added, are uniformly mixed to get with antibacterial
The Chinese medicine mouth wash of effect.
Embodiment 6
A kind of Chinese medicine mouth wash with bacteriostasis, raw material components and weight percent are as follows: 20 parts of Sweet tea, water chestnut skin
10 parts, 1 part of Radix zanthoxyli, 3 parts of Semi-pinnated Brake Herb, 5 parts of mother chrysanthemum, 80 parts of Huashan alum.
Preparation method includes the following steps,
(1) Sweet tea, water chestnut skin, Radix zanthoxyli, Semi-pinnated Brake Herb, Huashan alum and mother chrysanthemum the processing of raw material: are removed into impurity and mildew
Part, Sweet tea, water chestnut skin, Radix zanthoxyli, Semi-pinnated Brake Herb and Huashan alum flour is broken, sieving is better than weighing according to raw material weight, spare；
(2) extraction of Sweet tea and water chestnut skin: taking Sweet tea powder and water chestnut skin powder, is separately added into the second that concentration is 50%
Alcohol impregnates 1h, then ultrasonic extraction 2 times, and each 2h is filtered, and merging filtrate obtains mixed liquor I and mixed liquor I ', by mixed liquor
I and mixed liquor I ' boil off ethyl alcohol in 64 DEG C of decompressions respectively, obtain concentration be 1g/ml Sweet tea extracting solution and water chestnut skin extracting solution；
(3) extraction of Huashan alum: taking Huashan alum flour last, and the ethyl alcohol that concentration is 50% is added, and impregnates 1h, is then refluxed for extracting
2 times, each 2h, filtering, merging filtrate obtains mixed liquor II, mixed liquor II is boiled off ethyl alcohol in 64 DEG C of decompressions, obtaining concentration is
The Huashan alum extracting solution of 1g/ml；
(4) extraction of Semi-pinnated Brake Herb: taking Semi-pinnated Brake Herb powder, and the ethyl alcohol that concentration is 50% is added, and impregnates 1h, is then refluxed for extracting
2 times, each 2h, filtering, merging filtrate obtains mixed liquor III, mixed liquor III is boiled off ethyl alcohol in 64 DEG C of decompressions, obtaining concentration is
The Semi-pinnated Brake Herb extracting solution of 1g/ml；
(5) extraction of Radix zanthoxyli: taking Radix zanthoxyli powder, and the ethyl alcohol that concentration is 50% is added, and impregnates 30min, then ultrasonic
It extracts 2 times, each 30min, filtering, merging filtrate obtains mixed liquor IV, mixed liquor IV is boiled off ethyl alcohol in 64 DEG C of decompressions, is obtained
The Radix zanthoxyli extracting solution for being 1g/ml to concentration；
(6) extraction of mother chrysanthemum: taking mother chrysanthemum, adds water to cook 2 times, and the additional amount of water is 6-8 times of solid matter, is added for the first time
Amount is 8 times of solid matter, is then gradually reduced, each 2h mixes decoction liquor, obtains mixed liquor V, and mixed liquor V is existed
It is concentrated under reduced pressure at 66 DEG C into medicinal extract, obtains the mother chrysanthemum medicinal extract that 1g decoction is equivalent to 1g crude drug；
(7) preparation of Chinese medicine mouth wash: Sweet tea extracting solution, water chestnut skin extracting solution, Huashan alum extracting solution, Semi-pinnated Brake Herb are extracted
Liquid, Radix zanthoxyli extracting solution, mother chrysanthemum medicinal extract be mixed to get 55 parts of mixed liquor according to weight ratio 3:1:2.5:1.5:1:0.5, and
8 portions of peppermint oils, 17 parts of glycerol, 0.1 portion of preservative, 0.5 part of essence and 500 parts of water are added, are uniformly mixed to get with antibacterial work
Chinese medicine mouth wash.
Embodiment 7
A kind of Chinese medicine mouth wash with bacteriostasis, raw material components and weight percent are as follows: 5 parts of Sweet tea, water chestnut skin
20 parts, 10 parts of Radix zanthoxyli, 10 parts of Semi-pinnated Brake Herb, 2 parts of mother chrysanthemum, 20 parts of Huashan alum.
Preparation method includes the following steps,
(1) Sweet tea, water chestnut skin, Radix zanthoxyli, Semi-pinnated Brake Herb, Huashan alum and mother chrysanthemum the processing of raw material: are removed into impurity and mildew
Part, Sweet tea, water chestnut skin, Radix zanthoxyli, Semi-pinnated Brake Herb and Huashan alum flour is broken, sieving is better than weighing according to raw material weight, spare；
(2) extraction of Sweet tea and water chestnut skin: taking Sweet tea powder and water chestnut skin powder, is separately added into the second that concentration is 70%
Alcohol impregnates 1.5h, then ultrasonic extraction 2 times, and each 1.5h is filtered, and merging filtrate obtains mixed liquor I and mixed liquor I ', will mix
It closes liquid I and mixed liquor I ' boils off ethyl alcohol in 60 DEG C of decompressions respectively, obtain the Sweet tea extracting solution and the extraction of water chestnut skin that concentration is 1g/ml
Liquid；
(3) extraction of Huashan alum: taking Huashan alum flour last, and the ethyl alcohol that concentration is 70% is added, and impregnates 1.5h, is then refluxed for mentioning
It takes 2 times, each 1.5h, filters, merging filtrate obtains mixed liquor II, mixed liquor II is boiled off ethyl alcohol in 60 DEG C of decompressions, is obtained dense
Degree is the Huashan alum extracting solution of 1g/ml；
(4) extraction of Semi-pinnated Brake Herb: taking Semi-pinnated Brake Herb powder, and the ethyl alcohol that concentration is 70% is added, and impregnates 1.5h, is then refluxed for mentioning
It takes 2 times, each 1.5h, filters, merging filtrate obtains mixed liquor III, mixed liquor III is boiled off ethyl alcohol in 60 DEG C of decompressions, is obtained dense
Degree is the Semi-pinnated Brake Herb extracting solution of 1g/ml；
(5) extraction of Radix zanthoxyli: taking Radix zanthoxyli powder, and the ethyl alcohol that concentration is 70% is added, and impregnates 35min, then ultrasonic
It extracts 2 times, each 45min, filtering, merging filtrate obtains mixed liquor IV, mixed liquor IV is boiled off ethyl alcohol in 60 DEG C of decompressions, is obtained
The Radix zanthoxyli extracting solution for being 1g/ml to concentration；
(6) extraction of mother chrysanthemum: taking mother chrysanthemum, adds water to cook 2 times, and the additional amount of water is 6-8 times of solid matter, is added for the first time
Amount is 8 times of solid matter, is then gradually reduced, each 1.5h mixes decoction liquor, mixed liquor V is obtained, by mixed liquor V
It is concentrated under reduced pressure at 60 DEG C into medicinal extract, obtains the mother chrysanthemum medicinal extract that 1g decoction is equivalent to 1g crude drug；
(7) preparation of Chinese medicine mouth wash: Sweet tea extracting solution, water chestnut skin extracting solution, Huashan alum extracting solution, Semi-pinnated Brake Herb are extracted
Liquid, Radix zanthoxyli extracting solution, mother chrysanthemum medicinal extract be mixed to get 50 parts of mixed liquor according to weight ratio 3:1:2.5:1.5:1:0.5, and
7 portions of peppermint oils, 9 parts of glycerol and 300 parts of water are added, are uniformly mixed to get the Chinese medicine mouth wash with bacteriostasis.
Embodiment 8
A kind of Chinese medicine mouth wash with bacteriostasis, raw material components and weight percent are as follows: 50 parts of Sweet tea, water chestnut skin
15 parts, 5 parts of Radix zanthoxyli, 35 parts of Semi-pinnated Brake Herb, 5 parts of mother chrysanthemum, 100 parts of Huashan alum.
Preparation method includes the following steps,
(1) Sweet tea, water chestnut skin, Radix zanthoxyli, Semi-pinnated Brake Herb, Huashan alum and mother chrysanthemum the processing of raw material: are removed into impurity and mildew
Part, Sweet tea, water chestnut skin, Radix zanthoxyli, Semi-pinnated Brake Herb and Huashan alum flour is broken, sieving is better than weighing according to raw material weight, spare；
(2) extraction of Sweet tea and water chestnut skin: taking Sweet tea powder and water chestnut skin powder, is separately added into the second that concentration is 80%
Alcohol impregnates 1h, then ultrasonic extraction 2 times, and each 1h is filtered, and merging filtrate obtains mixed liquor I and mixed liquor I ', by mixed liquor
I and mixed liquor I ' boil off ethyl alcohol in 65 DEG C of decompressions respectively, obtain concentration be 1g/ml Sweet tea extracting solution and water chestnut skin extracting solution；
(3) extraction of Huashan alum: taking Huashan alum flour last, and the ethyl alcohol that concentration is 40% is added, and impregnates 1h, is then refluxed for extracting
2 times, each 1h, filtering, merging filtrate obtains mixed liquor II, mixed liquor II is boiled off ethyl alcohol in 65 DEG C of decompressions, obtaining concentration is
The Huashan alum extracting solution of 1g/ml；
(4) extraction of Semi-pinnated Brake Herb: taking Semi-pinnated Brake Herb powder, and the ethyl alcohol that concentration is 40% is added, and impregnates 1h, is then refluxed for extracting
2 times, each 1h, filtering, merging filtrate obtains mixed liquor III, mixed liquor III is boiled off ethyl alcohol in 65 DEG C of decompressions, obtaining concentration is
The Semi-pinnated Brake Herb extracting solution of 1g/ml；
(5) extraction of Radix zanthoxyli: taking Radix zanthoxyli powder, and the ethyl alcohol that concentration is 60% is added, and impregnates 30min, then ultrasonic
It extracts 2 times, each 30min, filtering, merging filtrate obtains mixed liquor IV, mixed liquor IV is boiled off ethyl alcohol in 65 DEG C of decompressions, is obtained
The Radix zanthoxyli extracting solution for being 1g/ml to concentration；
(6) extraction of mother chrysanthemum: taking mother chrysanthemum, adds water to cook 2 times, and the additional amount of water is 6-8 times of solid matter, is added for the first time
Amount is 8 times of solid matter, is then gradually reduced, each 1h mixes decoction liquor, obtains mixed liquor V, and mixed liquor V is existed
It is concentrated under reduced pressure at 68 DEG C into medicinal extract, obtains the mother chrysanthemum medicinal extract that 1g decoction is equivalent to 1g crude drug；
(7) preparation of Chinese medicine mouth wash: Sweet tea extracting solution, water chestnut skin extracting solution, Huashan alum extracting solution, Semi-pinnated Brake Herb are extracted
Liquid, Radix zanthoxyli extracting solution, mother chrysanthemum medicinal extract carry out being mixed to get 80 parts of mixed liquor, and 5 portions of peppermint oils, 20 parts of glycerol and 600 are added
Part water, is uniformly mixed to get the Chinese medicine mouth wash with bacteriostasis.
Performance test
1. fungistatic effect is tested
Detection method: Escherichia coli, staphylococcus aureus, Candida albicans these three bacterium are chosen, with reference to GB15979-
2002 appendix Cs 4 carry out bacteriostatic test (the processing time is 2 minutes).Concrete outcome is as shown in table 1:
The test of the mouthwash fungistatic effect of the present invention of table 1
| To Escherichia coli bacteriostasis rate | To staphylococcus aureus bacteriostasis rate | To Candida albicans bacteriostasis rate | |
| Embodiment 1 | 99.9% | 99.9% | 99.6% |
| Embodiment 2 | 99.5% | 99.5% | 99.3% |
| Embodiment 3 | 99.2% | 99.3% | 99.3% |
| Embodiment 4 | 99.4% | 99.1% | 99.2% |
| Embodiment 5 | 99.3% | 99.2% | 99.2% |
| Embodiment 6 | 98.9% | 99.0% | 99.1% |
| Embodiment 7 | 98.5% | 98.6% | 98.7% |
| Embodiment 8 | 98.2% | 98.4% | 98.1% |
As it can be seen from table 1 Chinese medicine mouth wash of the invention is to Escherichia coli bacteriostasis rate, antibacterial to staphylococcus aureus
Rate and 98% or more, up to 99.5% or more is reached to Candida albicans bacteriostasis rate, it is seen that Chinese medicine mouth wash of the invention
With apparent bactericidal effect.
2. mouthfeel and smell test
Choose 100 volunteers, the age-based stage is divided into juvenile group, Younger group, middle aged group and old group, every group of 25 people.
The Chinese medicine mouth wash prepared using embodiment 1 is used as test group, as a control group with common commercially available antibacterial mouthwash, record news take or
Experience containing gargling.Test result is as shown in table 2.
Table 2 Chinese medicine mouth wash mouthfeel and smell test result of the invention
3. permanence operation is tested
120 people of patient with mouth diseases such as swelling and aching of gum, bleeding gums, canker sore, halitosis is chosen, men and women is each
Half, the age is 12-60 years old；Four groups are randomly divided into, every group of 30 people.
Patient uses Chinese medicine mouth wash prepared by embodiment 1-4 respectively, and using containing method is gargled, each rinse time is not less than
Three minutes, rinse time are as follows: daily breakfast, lunch and dinner are after meal and before sleeping.Test counts its effective percentage after carrying out 30 days.
Criterion of therapeutical effect: be 1. obviously improved: subjective symptoms, which has, significantly to be mitigated or disappears；2. alleviating: subjective symptoms has
A degree of mitigation but less obvious；3. invalid: oral problem situation is not apparent from mitigation；4. deteriorating: oral problem is further
Aggravation.
Test result is as shown in table 3.
The Chinese medicine mouth wash Long-Term Properties test result of the invention of table 3
| ① | ② | ③ | ④ | It is efficient | |
| Embodiment 1 | 28 | 1 | 1 | 0 | 96.67% |
| Embodiment 2 | 27 | 2 | 1 | 0 | 96.67% |
| Embodiment 3 | 27 | 2 | 1 | 0 | 96.67% |
| Embodiment 4 | 27 | 1 | 2 | 0 | 93.33% |
It in summary it can be seen, Chinese medicine mouth wash smell faint scent of the invention, mouthfeel is soft not to stimulate, will not be to mouth disease
Patient brings sense of discomfort；With good bactericidal, anti-inflammatory analgesic effect, the patient for being suitable for all age group is used, long
Phase using effect more preferably, can be effectively improved the multiple oral disease patient's condition.
Claims (10)
1. a kind of Chinese medicine mouth wash with bacteriostasis, which is characterized in that its raw material components and weight percent are as follows: Sweet tea 5-
50 parts, 5-20 parts of water chestnut skin, 1-10 parts of Radix zanthoxyli, 3-40 parts of Semi-pinnated Brake Herb, 1-10 parts of mother chrysanthemum, alum 1-100 parts of the Huashan.
2. the Chinese medicine mouth wash according to claim 1 with bacteriostasis, which is characterized in that its raw material components and weight
Percentage are as follows: 20-30 parts of Sweet tea, 10-15 parts of water chestnut skin, 3-7 parts of Radix zanthoxyli, 20-25 parts of Semi-pinnated Brake Herb, 3-7 parts of mother chrysanthemum, Huashan alum
50-60 parts.
3. the Chinese medicine mouth wash according to claim 2 with bacteriostasis, which is characterized in that its raw material components and weight
Percentage are as follows: 25 parts of Sweet tea, 13 parts of water chestnut skin, 5 parts of Radix zanthoxyli, 22 parts of Semi-pinnated Brake Herb, 5 parts of mother chrysanthemum, 55 parts of Huashan alum.
4. a kind of preparation method of the Chinese medicine mouth wash a method according to any one of claims 1-3 with bacteriostasis, feature exist
In, include the following steps,
(1) processing of raw material: removing impurity and mildew part for Sweet tea, water chestnut skin, Radix zanthoxyli, Semi-pinnated Brake Herb, Huashan alum and mother chrysanthemum,
Sweet tea, water chestnut skin, Radix zanthoxyli, Semi-pinnated Brake Herb and Huashan alum flour is broken, and sieving is better than weighing according to raw material weight, spare；
(2) extraction of Sweet tea and water chestnut skin: taking Sweet tea powder and water chestnut skin powder, is separately added into ethyl alcohol, impregnates 1-2h, then surpasses
Sound extracts 2-3 times, each 1-2h, and filtering, merging filtrate obtains mixed liquor I and mixed liquor I ', by mixed liquor I and mixed liquor I '
Decompression boils off ethyl alcohol respectively, obtains Sweet tea extracting solution and water chestnut skin extracting solution；
(3) extraction of Huashan alum: taking Huashan alum flour last, ethyl alcohol be added, impregnate 1-2h, is then refluxed for extracting 2-3 times, each 1-
2h, filtering, merging filtrate obtain mixed liquor II, and the decompression of mixed liquor II is boiled off ethyl alcohol, obtains Huashan alum extracting solution；
(4) extraction of Semi-pinnated Brake Herb: taking Semi-pinnated Brake Herb powder, and ethyl alcohol is added, and impregnates 1-2h, is then refluxed for extracting 2-3 times, each 1-
2h, filtering, merging filtrate obtain mixed liquor III, and the decompression of mixed liquor III is boiled off ethyl alcohol, obtains Semi-pinnated Brake Herb extracting solution；
(5) extraction of Radix zanthoxyli: taking Radix zanthoxyli powder, and ethyl alcohol is added, and impregnates 30-40min, then ultrasonic extraction 2-3 times, every time
30-60min, filtering, merging filtrate obtain mixed liquor IV, and the decompression of mixed liquor IV is boiled off ethyl alcohol, obtains Radix zanthoxyli extracting solution；
(6) extraction of mother chrysanthemum: taking mother chrysanthemum, add water to cook 2-3 times, and each 1-2h mixes decoction liquor, obtains mixed liquor V, will
Mixed liquor V is concentrated under reduced pressure into medicinal extract, obtains mother chrysanthemum medicinal extract；
(7) preparation of Chinese medicine mouth wash: by Sweet tea extracting solution, water chestnut skin extracting solution, Huashan alum extracting solution, Semi-pinnated Brake Herb extracting solution,
Radix zanthoxyli extracting solution, mother chrysanthemum medicinal extract are mixed, and peppermint oil, glycerol and water is added, and are uniformly mixed to get with bacteriostasis
Chinese medicine mouth wash.
5. the preparation method of the Chinese medicine mouth wash according to claim 4 with bacteriostasis, which is characterized in that the second
The concentration of alcohol is 40-80%.
6. the preparation method of the Chinese medicine mouth wash according to claim 4 with bacteriostasis, which is characterized in that decompression is steamed
Going temperature setting when ethyl alcohol is 60-65 DEG C.
7. the preparation method of the Chinese medicine mouth wash according to claim 4 with bacteriostasis, which is characterized in that step
(6) in, the additional amount of water is 6-8 times of solid matter, and additional amount is 8 times of solid matter for the first time, is then gradually reduced.
8. the preparation method of the Chinese medicine mouth wash according to claim 4 with bacteriostasis, which is characterized in that step
(6) in, mixed liquor V is concentrated under reduced pressure at 60-68 DEG C into medicinal extract.
9. the preparation method of the Chinese medicine mouth wash according to claim 4 with bacteriostasis, which is characterized in that by Sweet tea
Extracting solution, water chestnut skin extracting solution, Huashan alum extracting solution, Semi-pinnated Brake Herb extracting solution, Radix zanthoxyli extracting solution, mother chrysanthemum medicinal extract are according to weight ratio
3:1:2.5:1.5:1:0.5 carries out being mixed to get 50-80 parts of mixed liquor, and be added 5-20 portions of peppermint oils, 5-20 parts of glycerol and
300-600 water is uniformly mixed to get the Chinese medicine mouth wash with bacteriostasis.
10. the preparation method of the Chinese medicine mouth wash according to claim 4 with bacteriostasis, which is characterized in that described
0.05-0.1 portions of preservatives, 0.5-0.8 parts of essence are additionally added in step (7).
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