CN108653081A - Compound Jin jasmine tea mouthwash and preparation method thereof - Google Patents
Compound Jin jasmine tea mouthwash and preparation method thereof Download PDFInfo
- Publication number
- CN108653081A CN108653081A CN201810628338.XA CN201810628338A CN108653081A CN 108653081 A CN108653081 A CN 108653081A CN 201810628338 A CN201810628338 A CN 201810628338A CN 108653081 A CN108653081 A CN 108653081A
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- CN
- China
- Prior art keywords
- jasmine tea
- mouthwash
- camellia nitidissima
- compound jin
- glabrous sarcandra
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/82—Theaceae (Tea family), e.g. camellia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
Abstract
The invention discloses a kind of compound Jin jasmine tea mouthwashes and preparation method thereof.It is demonstrated experimentally that the present invention has selective bacteriostasis, inhibiting effect is played to pathogenic bacteria of decayed tooth Streptococcus sanguis, Streptococcus mutans, lactobacillus acidophilus, but act on probiotics Lactobacillus rhamnosus and L. casei casei unrestraint.Therefore, the present invention provides new approach for deep development Camellia nitidissima, also adds new varieties for functional form mouthwash.
Description
Technical field
The invention belongs to mouthwash technical fields more particularly to a kind of compound Jin jasmine tea mouthwash and preparation method thereof.
Background technology
With the improvement of people's living standards, oral hygiene is greatly paid attention to, oral cleaning amenities is also increasingly rich
Richness has toothpaste, mouthwash, dental floss, chewing gum etc..Wherein, product of the mouthwash as a kind of cleaning oral cavity easily and fast,
The defect of toothpaste cannot be used whenever and wherever possible by having been relatively well made up with it, be used at present more and more extensive.In recent years, due to consumption
Person's health care consciousness enhances, and more requirements are proposed to mouthwash, some auxiliary are also added other than cleaning the teeth and prevent oral cavity disease
Disease has oral cavity the function of nursing role.Therefore, the product with various functions becomes the market mainstream in domestic and international mouthwash；
Again since active constituent contained in Chinese medicinal plant has the advantages that the Western medicine such as natural, safety are incomparable, therefore Chinese medicine in the market
Active component function type mouthwash becomes the emphasis of Developing.
Saprodontia mostly caused by oral microorganism group gets muddled, think by research at present, the disorderly generation of micropopulation because
It is known as many, the mainly factors such as eating habit, oral cleaning custom and causes oral cavity variation of ecology and environment, it is normal thin to make
Bacterium becomes conditioned pathogen, causes dental caries.Saprodontia can be with secondary pulpitis and periapical inflammation, or even can cause alveolar bone and jawbone
Inflammation etc. causes to suffer from tooth all destructions, be influenced on people's health huge.In daily life mostly using containing anti-caries effectively at
Toothpaste, mouthwash divided etc. carrys out pre- anti-caries, and its mechanism of action predominantly inhibits or kill cariogenic bacterium, maintains the micro- life in oral cavity
Object homeostasis.
Camellia nitidissima Camellia nitidissima be Theaceae Theaceae Camellias Camellia evergreen shrubs or
Dungarunga, flower and leaf are the civil traditional medication of Zhuang nationality in Guangxi, according to《Guangxi Chinese medicine standard》、《Modern Compendium of Materia Medica》Deng note
It carries, can be used for preventing sphagitis, ephritis, dysentery, tumour, has blood in stool, the illnesss such as hypertension and irregular menstruation.Golden flower tea sets flavones,
A variety of chemical compositions such as polysaccharide, plant polyphenol, saponin(e have the works such as antibacterial, reducing blood lipid, anti-oxidant, hypoglycemic in pharmacological research
With.Glabrous Sarcandra Herb Sarcandra glabra (Thunb.) Makai is complete stool or the root of Chloranthaceae plant Chloranthus glaber, contains flavones
The chemical compositions such as class, sesquiterpenoids, Coumarins, for diseases such as stomatitis, traumatic injuries.
Invention content
The technical problem to be solved in the present invention is to provide a kind of compound Jin jasmine tea mouthwashes and preparation method thereof, and gained is gargled
Aquatic products tool is acted on by pre- anti-caries.
In order to solve the above technical problems, the present invention uses following technical scheme：
The application of Camellia nitidissima leaf and Glabrous Sarcandra Herb in terms of the mouthwash for preparing pre- anti-caries.
Saprodontia is caused by Streptococcus sanguis, Streptococcus mutans, lactobacillus acidophilus.
Compound Jin jasmine tea mouthwash, is mainly made of Camellia nitidissima leaf and Glabrous Sarcandra Herb.
Camellia nitidissima leaf and the swollen weight ratio of Glabrous Sarcandra Herb are 5：2.
Above-mentioned compound Jin jasmine tea mouthwash, by Camellia nitidissima leaf, Glabrous Sarcandra Herb, glycerine, edible alcohol, menthol, sorbic acid
Potassium and saccharin sodium are made.
The preparation method of above-mentioned compound Jin jasmine tea mouthwash is carried out by following operation：Take Camellia nitidissima leaf 50g and Glabrous Sarcandra Herb
After 20g net systems, add 10 times of water to decoct twice, filtered after decoction, merges that be concentrated into density after filtrate twice be 1.02~1.03；Add
300ml edible alcohols make total alcohol content be 70%~75%, are refrigerated for 24 hours after sealing；Recovered alcohol is to alcohol-free taste, glycerol adding
50ml, potassium sorbate 10g, saccharin sodium 1g are sufficiently stirred, then are added and are stirred after 4g menthols are dissolved with 100ml edible alcohols,
It adds water to 12000ml, finished product is stood for 24 hours later, takes supernatant to obtain the final product.
It decocts twice, first time 30min, second of 40min.
The problem of not excavated fully for Camellia nitidissima medical value, inventor has found through further investigation, by golden camellia tea
Mouthwash prepared by son and Glabrous Sarcandra Herb has the function of anti-pathogenic bacteria of decayed tooth Streptococcus sanguis, Streptococcus mutans, lactobacillus acidophilus.According to
This, inventor has developed a kind of compound Jin jasmine tea mouthwash and preparation method thereof.It is demonstrated experimentally that the present invention has selectivity antibacterial
Effect plays inhibiting effect to pathogenic bacteria of decayed tooth Streptococcus sanguis, Streptococcus mutans, lactobacillus acidophilus, but to probiotics rhamnose breast
Bacillus and L. casei casei unrestraint effect.Therefore, the present invention provides new approach for deep development Camellia nitidissima,
Also it is that functional form mouthwash adds new varieties.
Specific implementation mode
One, mouthwash formula
Camellia nitidissima leaf 50g, Glabrous Sarcandra Herb 20g, glycerine 50ml, edible alcohol 100ml, menthol 4g, potassium sorbate 10g sugar
Smart sodium 1g.
Two, production technology
After taking Camellia nitidissima leaf 50g and Glabrous Sarcandra Herb 20g net systems, add 10 times of water to decoct twice, filtered after decoction, for the first time
30min, second of 40min；Merge that be concentrated into density after filtrate twice be 1.02~1.03, volume is about 100ml after concentration；Add
300ml edible alcohols make total alcohol content be 70%~75%, are refrigerated for 24 hours after sealing；Recovered alcohol is to alcohol-free taste, glycerol adding
50ml, potassium sorbate 10g, saccharin sodium 1g are sufficiently stirred, then are added and are stirred after 4g menthols are dissolved with 100ml edible alcohols,
12000ml is added water to, later stands finished product for 24 hours, filling supernatant is taken, sterilizing, labels to get compound Jin jasmine tea mouthwash.
Content is in per 100ml mouthwashes：Compound Jin jasmine tea liquid 1ml, alcohol 1ml (1%), glycerine 0.5ml
(0.5%), menthol 0.04g, potassium sorbate 0.1g (0.1%), 0.02~0.03g of saccharin sodium.
Three, antibacterial experiment
1. method
Agar dilution.
2. material
Three plants of oral cavity pathogen Streptococcus sanguis (ATCC49295), Streptococcus mutans (ATCC25175), lactobacillus acidophilus
(gim1.412), three plants of oral cavity probiotics are respectively lactobacillus acidophilus (gim1.208), Lactobacillus rhamnosus (gim1.325), do
Lactobacillus paracasei cheese subspecies (giml.159), the above bacterium are purchased from Guangdong Province's Culture Collection.
Soybean casein agar medium, sheep blood, MRS culture mediums are purchased from the triumphant biological Co., Ltd of ring.
3. experimental method
According to agar medium is prepared in culture medium specification, 15ml is taken to be dispensed in 50ml conical flasks according to number,
The average each sample of each culture medium needs 11, i.e. blank control one, other dilute 10 concentration according to 2 times of dilution methods.
It is taken out while hot after the culture medium high pressure sterilization dispensed, takes 15ml stostes (aforementioned compound Jin jasmine tea mouthwash obtained, similarly hereinafter)
It is mixed into No. 1 plate with agar；It is another that 15ml stostes is taken to add and be No. 2 mixed liquors after mixing in 15ml distilled water, it is mixed from No. 2
Close that extract 15ml in liquid and be added in 15ml distilled water be No. 3 mixed liquors after mixing, and so on to No. 10 mixed liquors, every number
Mixed liquor is added on two plates.As parallel laboratory test.Incubation time is 48 hours to 4 kinds of anaerobic bacterias in the incubator, other 2 kinds thin
Incubation time is 24 hours to bacterium in the incubator.
4. experimental result
1 compound Jin jasmine tea mouthwash antibacterial experiment result of table
5. interpretation of result
As shown in table 1, compound Jin jasmine tea mouthwash of the invention is to pathogenic bacteria Streptococcus sanguis, Streptococcus mutans, acidophilus breast
Bacillus all has certain bacteriostasis, wherein the inhibiting effect to Streptococcus mutans is best, to Streptococcus sanguis inhibiting effect time
It.And probiotics Lactobacillus rhamnosus and L. casei casei unrestraint are acted on, then understand Camellia nitidissima bacteriostasis
With selectivity.
Claims (7)
1. the application of Camellia nitidissima leaf and Glabrous Sarcandra Herb in terms of the mouthwash for preparing pre- anti-caries.
2. application according to claim 1, it is characterised in that：The saprodontia is by Streptococcus sanguis, Streptococcus mutans, acidophilus breast
Bacillus causes.
3. a kind of compound Jin jasmine tea mouthwash, it is characterised in that be mainly made of Camellia nitidissima leaf and Glabrous Sarcandra Herb.
4. compound Jin jasmine tea mouthwash according to claim 3, it is characterised in that：The Camellia nitidissima leaf and Glabrous Sarcandra Herb are swollen
Weight ratio is 5: 2.
5. compound Jin jasmine tea mouthwash according to claim 4, it is characterised in that by Camellia nitidissima leaf, Glabrous Sarcandra Herb, glycerine,
Edible alcohol, menthol, potassium sorbate and saccharin sodium are made.
6. the preparation method of the compound Jin jasmine tea mouthwash described in claim 5, it is characterised in that carried out by following operation：Take gold
After jasmine tea leaf 50g and Glabrous Sarcandra Herb 20g net systems, add 10 times of water to decoct twice, filtered after decoction, is concentrated into after merging filtrate twice
Density is 1.02~1.03；Add 300ml edible alcohols that total alcohol content is made to be 70%~75%, is refrigerated for 24 hours after sealing；Recovered alcohol
To alcohol-free taste, glycerol adding 50ml, potassium sorbate 10g, saccharin sodium 1g are sufficiently stirred, then by 4g menthols 100ml edible wines
Stirring is added after essence dissolving, adds water to 12000ml, finished product is stood for 24 hours later, takes supernatant to obtain the final product.
7. the preparation method of compound Jin jasmine tea mouthwash according to claim 6, it is characterised in that：It is described to decoct twice,
First time 30min, second of 40min.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810628338.XA CN108653081B (en) | 2018-06-19 | 2018-06-19 | Compound golden camellia mouthwash and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810628338.XA CN108653081B (en) | 2018-06-19 | 2018-06-19 | Compound golden camellia mouthwash and preparation method thereof |
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| Publication Number | Publication Date |
|---|---|
| CN108653081A true CN108653081A (en) | 2018-10-16 |
| CN108653081B CN108653081B (en) | 2020-11-06 |
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| CN201810628338.XA Active CN108653081B (en) | 2018-06-19 | 2018-06-19 | Compound golden camellia mouthwash and preparation method thereof |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110075044A (en) * | 2019-05-23 | 2019-08-02 | 广西中医药大学 | A kind of Chinese medicine mouth wash and preparation method thereof with bacteriostasis |
| CN110327262A (en) * | 2019-08-07 | 2019-10-15 | 广西中医药大学 | Sweet golden gargle of one kind and its preparation method and application |
| CN112137940A (en) * | 2019-06-26 | 2020-12-29 | 广西中医药大学 | Compound sugarcane leaf toothpaste and preparation method thereof |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110075044A (en) * | 2019-05-23 | 2019-08-02 | 广西中医药大学 | A kind of Chinese medicine mouth wash and preparation method thereof with bacteriostasis |
| CN112137940A (en) * | 2019-06-26 | 2020-12-29 | 广西中医药大学 | Compound sugarcane leaf toothpaste and preparation method thereof |
| CN112137940B (en) * | 2019-06-26 | 2022-11-15 | 广西中医药大学 | Compound sugarcane leaf toothpaste and preparation method thereof |
| CN110327262A (en) * | 2019-08-07 | 2019-10-15 | 广西中医药大学 | Sweet golden gargle of one kind and its preparation method and application |
| CN110327262B (en) * | 2019-08-07 | 2022-04-15 | 广西中医药大学 | Ganjin gargle and preparation method and application thereof |
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| Publication number | Publication date |
|---|---|
| CN108653081B (en) | 2020-11-06 |
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