CN102698069A - Oral care liquid for preventing chemotherapy-induced oral mucositis - Google Patents
Oral care liquid for preventing chemotherapy-induced oral mucositis Download PDFInfo
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Abstract
The invention discloses an oral care liquid for preventing chemotherapy-induced oral mucositis, aiming to solve prevention problem of chemotherapy-induced oral mucositis. The oral liquid comprises is characterized by being prepared from Chinese herbs and comprising the following Chinese herbs by weight: 6-10 parts of Radix Serissae, 8-15 parts of Fructus Ligustri Lucidi, 8-15 parts of Ficus virens, 6-10 parts of Radix Rehmanniae, 6-10 parts of Radix Scrophulariae, 8-15 parts of Radix Ophiopogonis, 6-10 parts of Radix Adenophorae, 8-15 parts of Rhizoma Anemarrhenae and 3-6 parts of Herba Pileae Scriptae. Clinical tests prove that the oral care liquid has good effect in preventing chemotherapy-induced oral mucositis, and is suitable for clinical application and popularization.
Description
Technical field
The present invention relates to the field of Chinese medicines, be specifically related to prevent the oral nursing liquid of oral mucositis due to the chemotherapy.
Background technology
Oral mucositis (Oral Mucositis; OM) be meant the struvite of oral cavity and the reaction of ulcer property; It is comparatively common and one of the severe complications of malignant tumor patient chemotherapy; Conventional chemotherapy patient stomatitis incidence rate is up to 40%, and the incidence rate of child patient, tumor of head and neck and combined chemotherapy person's stomatitis is higher.Its cardinal symptom is local pain and gustatory anesthesia, especially with feed, speaking and running into hot and cold, sour, sweet etc. stimulates that afterwards pain is more obvious.It directly influences patient's feed, has brought very big misery to the patient.Simultaneously, therefore also can be and delay treatment, the compelled dosage that reduces chemotherapeutics brings adverse influence to prognosis.Serious oral mucositis also is the principal element of lethal infection, and according to relevant bibliographical information, its septicemia of 64% patients undergoing chemotherapy is by due to the oral mucositis.The generation of prevention oral mucositis is also in time treated oral mucositis, to smooth completion chemotherapy, reduces complication, and it is significant to ensure that chemotherapy successfully reaches the quality of life of improving the patient.
Up to the present, the method to the prevention of chemotherapy stomatitis mainly is: rinsing the mouth 0.8% allopurinol solution (compound method is allopurinol sheet 2 gram grind into powder+normal saline 250 ml); The rinsing the mouth method is 3 times/d, 20 ml/ time, rinsing the mouth 3 ~ 5 min, and the rinsing the mouth time is after three cold after the meal boiled water are gargled, to begin to end of chemotherapy from chemotherapy.The weak point of this method is: total effective rate is on the low side, probably maintains about 60%.
Summary of the invention
Technical assignment of the present invention is the deficiency to above prior art, and the oral nursing liquid of oral mucositis due to the sure prevention chemotherapy of a kind of curative effect is provided.
The technical scheme that the present invention solves its technical problem is: a kind of oral nursing liquid that prevents oral mucositis due to the chemotherapy, it is characterized in that processing by plurality of Chinese, and its composition of raw materials and weight proportion are: 6 ~ 10 parts of Radix Serissae; 8 ~ 15 parts of Fructus Ligustri Lucidi, 8 ~ 15 parts of Folium fici wightianae (Ficus wightiana Wall)s, 6 ~ 10 parts in the Radix Rehmanniae; 6 ~ 10 parts of Radix Scrophulariaes, 8 ~ 15 parts of Radix Ophiopogonis, 6 ~ 10 parts of Radix Adenophorae (Radix Glehniae); 8 ~ 15 parts of the Rhizoma Anemarrhenaes, 3 ~ 6 parts of Herba Sarcandraes.
Its optimum weight proportioning is: 8 parts of Radix Serissae, 10 parts of Fructus Ligustri Lucidi, 10 parts of Folium fici wightianae (Ficus wightiana Wall)s, 8 parts in the Radix Rehmanniae, 8 parts of Radix Scrophulariaes, 10 parts of Radix Ophiopogonis, 8 parts of Radix Adenophorae (Radix Glehniae), 10 parts of the Rhizoma Anemarrhenaes, 5 parts of Herba Sarcandraes.
Wherein said: Radix Serissae is the herb strain of dicotyledon medicine Maguireothamnus speciosus Radix Serissae Serissa serissoides (DC.) Druce or Serissa foetida Serissa japonica (Thunb.) Thunb..The nature and flavor toil; Cool; Nontoxic.Return liver; Spleen channel.Merit can be dispeled the wind; Dampness removing; Heat clearing away; Detoxifcation.
Fructus Ligustri Lucidi is the dry mature fruit of Oleaceae plant Fructus Ligustri Lucidi Ligustrum lucidum Ait..Nature and flavor are sweet, bitter, cold.Return liver, kidney channel.But the merit nourishing the liver and kidney, black hair makes eye bright.
Folium fici wightianae (Ficus wightiana Wall) is moraceae plants shaft of a writing brush banyan Ficus virens Ait. the leaf of [F.wightana (Miq.)] Benth..Sweet in the mouth; Little hardship; Property is put down.But merit heat-clearing and toxic substances removing; Removing damp to relieve itching.
The Radix Rehmanniae is the scrophulariaceae rehmannia glutinosa plant rhizome.Nature and flavor sweetness and bitterness, cold.GUIXIN, liver, kidney channel.But the merit YIN nourishing is nourished blood.
Radix Scrophulariae for Scrophulariaceae Radix Scrophulariae kakudensis Scrophularia kaku densis Franch., is used as medicine with root.Nature and flavor are bitter, salty, cold.But the merit YIN nourishing, pathogenic fire reducing, relieving restlessness, detoxifcation.
Radix Ophiopogonis, be the dried root of liliaceous plant Radix Ophiopogonis (dwarf lilyturf) Ophiopogon japonicus (Thunb.) Ker-Gawl..Nature and flavor are sweet, and little hardship is slightly cold.GUIXIN, lung, stomach warp.But the merit YIN nourishing and the production of body fluid promoting, lung moistening clears away heart-fire.
Radix Adenophorae (Radix Glehniae) is the dry root of campanulaceae plant adenophora tetraphylla Adenophora tetraphylla (Thunb.) Fisch. or Radix Adenophorae (Radix Glehniae) Adenophora stricta Miq..Nature and flavor are sweet, are slightly cold.Attach to the lung and stomach meridians.But the merit nourishing YIN and clearing away lung-heat is reduced phlegm, QI invigorating.
The Rhizoma Anemarrhenae is the dry rhizome of liliaceous plant Rhizoma Anemarrhenae Anemarrhena asphodeloides Bunge..Nature and flavor are bitter, sweet, and are cold.Return lung, stomach, kidney channel.But the merit clearing away heat-fire promotes the production of body fluid and moisturizes.
Herba Sarcandrae is the dry Herb of Chloranthaceae plant plait Corallium Japonicum Kishinouye Sarcandra glabra (Thunb.) Nakai.Bitter, hot, flat.GUIXIN, Liver Channel.But the merit clearing away heat and cooling blood, the speckle removing of invigorating blood circulation, dispelling wind and removing obstruction in the collateral.
Composition principle: chemotherapeutics in killing tumor cell to the also toxigenicity effect of histiocyte of molecular marker for increased proliferation; Promptly block ribonucleic acid and little formation and utilization of giving birth to element; Destroy the growth of mucosal epithelium cell, suppress salivary gland secretion, cause oral mucosa drying, atrophy attenuation, fragility to increase; Resist the ability drop of antibacterial, virus, fungus, ulcer then is inflamed.Chemotherapy causes that the characteristics of oral mucositis are pale for the beginning mucosa, indentation occurs, occurs big or small petechia of several grain of rices and blood blister, swelling, the erosion of mucosa ulceration then; Form one or about 0. 2 cm of several diameters ~ 0. 5 cm ulcer; Red and swollen, pain around the ulcer, mucosa is extensively rotten to the corn when serious, can reach pharynx and esophagus; The deep can reach the flesh layer, surface coverage one deck white membranoid substance and slough.In the traditional Chinese medical science, how oral mucositis due to the chemotherapy is by due to the whole body internal organs QI and blood regulatory function obstacle; So oral mucositis is a mark, the pathological changes of internal organs QI and blood is this, and simulataneous insufficiency and excessive is the characteristics of primary disease; But each function fails more after the chemotherapy, to violate primary disease be main with deficiency syndrome often.It is principle that treatment should be set upright to dispel, eliminating evil should setting about from the clearing away heat-damp and promoting diuresis detoxifcation; Set upright to be main with Yin-nourishing and body fluid promoting.Get Radix Serissae, Folium fici wightianae (Ficus wightiana Wall) expelling wind and removing dampness, heat-clearing and toxic substances removing in the prescription of the present invention, with eliminating evil; Radix Rehmanniae nourishing YIN and benefiting blood, the Radix Scrophulariae nourishing YIN to lower pathogenic fire, the Fructus Ligustri Lucidi nourishing the liver and kidney, Radix Ophiopogonis, Radix Adenophorae (Radix Glehniae) YIN nourishing and the production of body fluid promoting are to set upright; Rhizoma Anemarrhenae clearing away heat-fire, promote the production of body fluid and moisturize, reinforcement and elimination in combination; Herba Sarcandrae clearing away heat and cooling blood speckle removing is started with from blood system; More than all medicines share, play the effect of strengthening vital QI to eliminate pathogenic factors altogether, can prevent oral mucositis due to the chemotherapy.
Compared with prior art, the present invention has following characteristics:
1, reasonable recipe is attached most importance to benefit, relies mainly on prevention;
2, added blood system medicine Herba Sarcandrae, with the removing heat from blood collateral dredging.
The specific embodiment
Below in conjunction with practical situation, specific embodiments of the invention elaborates.
Embodiment 1, the crude drug weight proportion: Radix Serissae 6g, Fructus Ligustri Lucidi 8g, Folium fici wightianae (Ficus wightiana Wall) 8g, Radix Rehmanniae 6g, Radix Scrophulariae 6g, Radix Ophiopogonis 8g, Radix Adenophorae (Radix Glehniae) 6g, Rhizoma Anemarrhenae 8g, Herba Sarcandrae 3g.
Embodiment 2, the crude drug weight proportion: Radix Serissae 10g, Fructus Ligustri Lucidi 15g, Folium fici wightianae (Ficus wightiana Wall) 15g, Radix Rehmanniae 10g, Radix Scrophulariae 10g, Radix Ophiopogonis 15g, Radix Adenophorae (Radix Glehniae) 10g, Rhizoma Anemarrhenae 15g, Herba Sarcandrae 6g.
Embodiment 3, the crude drug weight proportion: Radix Serissae 8g, Fructus Ligustri Lucidi 10g, Folium fici wightianae (Ficus wightiana Wall) 10g, Radix Rehmanniae 8g, Radix Scrophulariae 8g, Radix Ophiopogonis 10g, Radix Adenophorae (Radix Glehniae) 8g, Rhizoma Anemarrhenae 10g, Herba Sarcandrae 5g.
During use, with Chinese medicine Radix Serissae of the present invention, Fructus Ligustri Lucidi, Folium fici wightianae (Ficus wightiana Wall), the Radix Rehmanniae, Radix Scrophulariae, Radix Ophiopogonis, Radix Adenophorae (Radix Glehniae), Herba Sarcandrae and Rhizoma Anemarrhenae decocte with water twice, merging filtrate.
Effective combination of said medicine is coordinated mutually, can effectively reach the purpose of oral mucositis due to the prevention chemotherapy, and side effect is less.The above results is that clinical data proves that fully interrelated data is following, wherein studies drug use and is the crude drug weight proportion among the embodiment 3.
1 object and method.
1.1 object in May, 2005 to 2006 year December, accepting fluorouracil is the chemotherapeutical patient of main cancer therapy drug totally 260 examples, male's 153 examples wherein, women's 107 examples, 24 ~ 80 years old age, 56 years old mean age.161 examples that wherein undergo surgery before the chemotherapy are accepted radiotherapy 6 examples, operation+radiotherapy 93 examples.The patient goes into set condition pathology and is diagnosed as malignant tumor; Contain fluorouracil drug in the chemotherapeutics; The patient first chemotherapy or once more the preceding oral cavity of chemotherapy all do not have ulcer and infection.
1.2 method.
1.2.1 divide into groups: be divided into two groups at random, matched group 103 examples and treatment are organized 157 examples and are observed contrast.Patient's age, sex, cancer do not constitute upward no significance difference between two groups.
1.2.2 Therapeutic Method: matched group rinsing the mouth 0. 8% allopurinol solution (compound method is allopurinol sheet 2 gram grind into powder+normal saline 250 ml); The treatment group rinsing the mouth embodiment of the invention 3 gained Chinese medicine decoction.Matched group is identical with treatment group rinsing the mouth method, i.e. 3 times/d, 20 ml/ time, rinsing the mouth 3 ~ 5 min, and the rinsing the mouth time is after three cold after the meal boiled water are gargled, to begin to end of chemotherapy from chemotherapy.
1.2.3 observation index: The World Health Organization (WHO) is divided into the 0-IV level with oral ulcer property mucositis: 0 grade: oral mucosa is no abnormal; The I level: oral mucosa has 1 ~ 2 < the 1. ulcer of 0 cm; The II level: oral mucosa has 1>1. 0 several aphthas of cm ulcer; The III level: oral mucosa has 2>1. 0 several aphthas of cm ulcer; IV level: have more than 2>1. the ulcer of 0 cm is or/and merge ulcer.
1.2.4 curative effect determinate standard:, patient's oral cavity is assessed according to oral mucosa evaluation criteria (OAG).Produce effects: oral ulcer property mucositis obviously absorbs, and primary affection is controlled, oral ulcer property mucositis by the IV level to the II level, by the III level to the I level, by II level restoration to 0 grade; Effectively: oral ulcer property mucositis partially absorbs, sx, oral ulcer property mucositis by the IV level to the III level, by the III level to the II level; Invalid: oral ulcer property mucositis no change or increase the weight of, symptom does not have improvement.
1.2.5 statistical analysis carries out statistical analysis with SPSS 13.0, < 0.05 expression has the significance meaning to P.
2. result.
The comparison of two groups of patient's oral mucositis incidence rates, degree: the oral mucositis incidence rate is through single factor χ after two groups of patient's chemotherapy
2Check analysis, comparing difference has statistical significance between group; The oral mucositis degree is through single factor χ
2Check analysis, comparing difference not statistically significant between group.
3. conclusion.
This result of study shows, the present invention prevents oral mucositis definite effect due to the chemotherapy, is worthy of promotion and application.
Claims (2)
1. an oral nursing liquid that prevents oral mucositis due to the chemotherapy is characterized in that being processed by plurality of Chinese, and its composition of raw materials and weight proportion are: 6 ~ 10 parts of Radix Serissae; 8 ~ 15 parts of Fructus Ligustri Lucidi, 8 ~ 15 parts of Folium fici wightianae (Ficus wightiana Wall)s, 6 ~ 10 parts in the Radix Rehmanniae; 6 ~ 10 parts of Radix Scrophulariaes, 8 ~ 15 parts of Radix Ophiopogonis, 6 ~ 10 parts of Radix Adenophorae (Radix Glehniae); 8 ~ 15 parts of the Rhizoma Anemarrhenaes, 3 ~ 6 parts of Herba Sarcandraes.
2. a kind of oral nursing liquid that prevents oral mucositis due to the chemotherapy according to claim 1 is characterized in that its weight proportion is: 8 parts of Radix Serissae, 10 parts of Fructus Ligustri Lucidi, 10 parts of Folium fici wightianae (Ficus wightiana Wall)s; 8 parts in the Radix Rehmanniae, 8 parts of Radix Scrophulariaes, 10 parts of Radix Ophiopogonis; 8 parts of Radix Adenophorae (Radix Glehniae), 10 parts of the Rhizoma Anemarrhenaes, 5 parts of Herba Sarcandraes.
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103751488A (en) * | 2014-01-30 | 2014-04-30 | 许加屯 | Medicine for treating high-sensitivity condition after neurosurgery operation |
| CN105902794A (en) * | 2016-06-07 | 2016-08-31 | 青岛大学附属医院 | Traditional Chinese medicine composition for oral radiotherapy mucositis care |
| CN107789518A (en) * | 2017-10-25 | 2018-03-13 | 林振 | A kind of oral nursing liquid of oral mucositis caused by Prophylactic chemotherapy |
| CN108653081A (en) * | 2018-06-19 | 2018-10-16 | 广西中医药大学 | Compound Jin jasmine tea mouthwash and preparation method thereof |
| CN113398205A (en) * | 2021-07-01 | 2021-09-17 | 李霞 | Anti-cancer oral care solution and preparation method thereof |
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