CN109528601A - Herbal mixture mouthwash and preparation method thereof - Google Patents
Herbal mixture mouthwash and preparation method thereof Download PDFInfo
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- CN109528601A CN109528601A CN201910054886.0A CN201910054886A CN109528601A CN 109528601 A CN109528601 A CN 109528601A CN 201910054886 A CN201910054886 A CN 201910054886A CN 109528601 A CN109528601 A CN 109528601A
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- mouthwash
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- 239000000203 mixture Substances 0.000 title claims abstract description 75
- 239000002324 mouth wash Substances 0.000 title claims abstract description 52
- 229940051866 mouthwash Drugs 0.000 title claims abstract description 51
- 238000002360 preparation method Methods 0.000 title claims abstract description 21
- 239000000284 extract Substances 0.000 claims abstract description 70
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 56
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- 239000003814 drug Substances 0.000 claims abstract description 34
- 241000205585 Aquilegia canadensis Species 0.000 claims abstract description 22
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- 229940041616 menthol Drugs 0.000 claims abstract description 17
- 239000000126 substance Substances 0.000 claims abstract description 14
- 241000180649 Panax notoginseng Species 0.000 claims abstract description 13
- 235000003143 Panax notoginseng Nutrition 0.000 claims abstract description 13
- 239000004909 Moisturizer Substances 0.000 claims abstract description 11
- 239000002253 acid Substances 0.000 claims abstract description 11
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- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 21
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- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 claims description 7
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- 239000004376 Sucralose Substances 0.000 claims description 4
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- NUVBSKCKDOMJSU-UHFFFAOYSA-N ethylparaben Chemical compound CCOC(=O)C1=CC=C(O)C=C1 NUVBSKCKDOMJSU-UHFFFAOYSA-N 0.000 claims description 4
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- 235000010234 sodium benzoate Nutrition 0.000 claims description 4
- 235000019408 sucralose Nutrition 0.000 claims description 4
- BAQAVOSOZGMPRM-QBMZZYIRSA-N sucralose Chemical group O[C@@H]1[C@@H](O)[C@@H](Cl)[C@@H](CO)O[C@@H]1O[C@@]1(CCl)[C@@H](O)[C@H](O)[C@@H](CCl)O1 BAQAVOSOZGMPRM-QBMZZYIRSA-N 0.000 claims description 4
- 239000011975 tartaric acid Substances 0.000 claims description 4
- 235000002906 tartaric acid Nutrition 0.000 claims description 4
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims description 3
- 239000004292 methyl p-hydroxybenzoate Substances 0.000 claims description 3
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- 235000008534 Capsicum annuum var annuum Nutrition 0.000 claims 1
- 240000008384 Capsicum annuum var. annuum Species 0.000 claims 1
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- 206010018286 Gingival pain Diseases 0.000 abstract description 8
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- 230000009286 beneficial effect Effects 0.000 abstract description 2
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- OHHNJQXIOPOJSC-UHFFFAOYSA-N stevioside Natural products CC1(CCCC2(C)C3(C)CCC4(CC3(CCC12C)CC4=C)OC5OC(CO)C(O)C(O)C5OC6OC(CO)C(O)C(O)C6O)C(=O)OC7OC(CO)C(O)C(O)C7O OHHNJQXIOPOJSC-UHFFFAOYSA-N 0.000 description 3
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- FFRBMBIXVSCUFS-UHFFFAOYSA-N 2,4-dinitro-1-naphthol Chemical compound C1=CC=C2C(O)=C([N+]([O-])=O)C=C([N+]([O-])=O)C2=C1 FFRBMBIXVSCUFS-UHFFFAOYSA-N 0.000 description 2
- 206010006326 Breath odour Diseases 0.000 description 2
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- 206010061218 Inflammation Diseases 0.000 description 2
- 241000186660 Lactobacillus Species 0.000 description 2
- 241000699666 Mus <mouse, genus> Species 0.000 description 2
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- 150000002576 ketones Chemical class 0.000 description 2
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- 238000005360 mashing Methods 0.000 description 2
- 235000012054 meals Nutrition 0.000 description 2
- 235000013372 meat Nutrition 0.000 description 2
- 208000030194 mouth disease Diseases 0.000 description 2
- 235000015097 nutrients Nutrition 0.000 description 2
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- 229920001817 Agar Polymers 0.000 description 1
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- 240000002853 Nelumbo nucifera Species 0.000 description 1
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- 241000605894 Porphyromonas Species 0.000 description 1
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 description 1
- 241000194017 Streptococcus Species 0.000 description 1
- 206010044029 Tooth deposit Diseases 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 230000035508 accumulation Effects 0.000 description 1
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- 244000052616 bacterial pathogen Species 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 235000014633 carbohydrates Nutrition 0.000 description 1
- 210000002318 cardia Anatomy 0.000 description 1
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- 230000002354 daily effect Effects 0.000 description 1
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- 238000011161 development Methods 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 230000002255 enzymatic effect Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
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- 238000011010 flushing procedure Methods 0.000 description 1
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- 230000002496 gastric effect Effects 0.000 description 1
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- 229960005150 glycerol Drugs 0.000 description 1
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- 230000034659 glycolysis Effects 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 229940099690 malic acid Drugs 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
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- 230000007406 plaque accumulation Effects 0.000 description 1
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- 238000011160 research Methods 0.000 description 1
- 210000002345 respiratory system Anatomy 0.000 description 1
- 210000003296 saliva Anatomy 0.000 description 1
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- 241000894007 species Species 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Birds (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Biotechnology (AREA)
- Rheumatology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Pain & Pain Management (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Botany (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cosmetics (AREA)
Abstract
The invention discloses a kind of herbal mixture mouthwashes, raw material including following parts by weight: 12-15% Chinese traditional medicine composition extract, 0.01-1% sweetener, 0.02-1% acid, 2-10% moisturizer, 0.01-0.4% preservative, 0.5-5% menthol and surplus water, wherein, the bulk pharmaceutical chemicals of Chinese medical extract include: 20-23 parts of wrinkled giant hyssop, 12-15 parts of Honeysuckle flower and 2-3 parts of Radix Notoginseng.The invention also discloses a kind of preparation methods of herbal mixture mouthwash.The present invention has anti-inflammatory, antibacterial, and effectively disposes and remain in intraoral swill and soft dirt, while the beneficial effect of rapid recovery gum pain.
Description
Technical field
The present invention relates to mouthwash preparation fields.It is more particularly related to a kind of herbal mixture mouthwash and its
Preparation method.
Background technique
As the development people's lives of society, work, activity description also increase very much, everybody to carry out everyday as
Social, negotiation is reported, work, amusement, the various activities for needing communication of affection exchange etc., if oneself have halitosis or
It smokes, drink, having eaten how peculiar smell foodstuff solves, being gargled with clear water, not solved the problems, such as, being chewed gum unbecoming (old in especially
Year), it brushes teeth, who will not be with it；Mouthwash is as a kind of oral health-care product, spy simple and easy to do with its, sanitation and hygiene
Favor of the point by people.
Currently, the Chinese medicine about mouthwash has very much, have mostly for removing oral cavity residue and fresh breath
Effect, but daily oral health care it is be at all prevent and control bacterial plaque correlation mouth disease, as gingivitis,
Periodontitis etc., gum are one of periodontium, are directly exposed in oral cavity, having in the plaque machine of dentogingival junction accumulation
Evil substance long term causes inflammation in gum, in addition dental calculus, ill fitting prosthesis, food impaction, transposition of teeth be crowded and mouth breathing
Deng presence, aggravated bacterial plaque accumulation and gingivitis, using effective chemicals carry out it is antibacterial or sterilization be control bacterial plaque
An effective way, conventional chemicals will cause the potential danger of drug resistance, and oral cavity caused by gingivitis periodontitis
It is extremely uncomfortable to will cause patient for pain.
For above situation, providing one kind has antibacterial, bactericidal effect for oral cavity common bacteria, and gum is effectively relieved
The mouthwash of pain is current urgent problem.
Summary of the invention
It is an object of the invention to solve at least the above problems, and provide the advantages of at least will be described later.
It is a still further object of the present invention to provide a kind of herbal mixture mouthwash, can anti-inflammatory, antibacterial, and effectively remove
Fall to remain in intraoral swill and soft dirt, while rapid recovery gum pain.
It is a still further object of the present invention to provide a kind of preparation method of herbal mixture mouthwash, by multiple boiling,
Alcohol precipitation obtains herbal mixture mouthwash, has anti-inflammatory fungistatic effect.
In order to realize these purposes and other advantages according to the present invention, a kind of herbal mixture mouthwash is provided, including
The raw material of following parts by weight:
12-15% Chinese traditional medicine composition extract, 0.01-1% sweetener, 0.02-1% acid, 2-10% moisturizer,
The water of 0.01-0.4% preservative, 0.5-5% menthol and surplus, wherein the bulk pharmaceutical chemicals of Chinese medical extract include: wrinkled giant hyssop 20-
23 parts, 12-15 parts of Honeysuckle flower and 2-3 parts of Radix Notoginseng.
Preferably, the bulk pharmaceutical chemicals of Chinese medical extract further include: 7-8 parts of Chinese prickly ash, 2-5 parts of eupatorium.
Preferably, sweetener be one or more of Sucralose, fructose, stevioside glycosides, acid be malic acid,
One of citric acid, tartaric acid, moisturizer are one of glycerol, sorbierite, and preservative is methylparaben, nipalgin second
One or more of ester, sodium benzoate.
A kind of preparation method of herbal mixture mouthwash living, comprising the following steps:
The following steps are included:
S1, wrinkled giant hyssop, Honeysuckle flower and panax mixed are weighed in proportion obtaining Traditional Chinese drug mixture, it is added into Traditional Chinese drug mixture
The boiling boiling of 15 times of gross mass amounts is extracted 2 times, first time 2h, second of 1.5h, is merged the filtered fluid of 2 extractions, is concentrated under reduced pressure
Concentrate is obtained, into concentrate plus ethyl alcohol makes alcohol content 60%, stands 24 hours after stirring and evenly mixing, is filtered to remove and precipitates to obtain alcohol
Heavy filtrate, alcohol precipitation filtrate are concentrated to give Chinese traditional medicine composition extract；
S2, Chinese traditional medicine composition extract, sweetener, acid, moisturizer, preservative, menthol and water are sufficiently mixed,
Packing to get.
Preferably, the specific gravity in step S1 at 80 DEG C of concentrate is 1.02-1.10,80 DEG C of Chinese traditional medicine composition extract when ratio
Weight is 1.06-1.12.
Preferably, wrinkled giant hyssop is fresh Radix agastaches, and fresh Radix agastaches are divided into three parts in step S1；
The solarization night that the fresh Radix agastaches of a copy of it carry out continuous 3-4 days bored is placed on 65 DEG C of drying in oven to constant weight
Afterwards, it clayed into power 100-200 mesh, and obtained Wrinkled Gianthyssop Herb, the water of 8 times of its gross mass amounts are added into Wrinkled Gianthyssop Herb, and impregnated 5h
Afterwards, it carries out steam distillation and extracts 4h, obtain Agastache rugosa；
Another fresh Radix agastaches is beaten after the lemon juice of 0.05 times of its gross mass amount, 1 times of water measured is added, and obtains slurry,
Slurry is cooled to -20 DEG C, thaw at RT is taken out after keeping 3h, obtains freezing slurry, 2 times of its gross mass is added into freezing slurry
The water of amount filters to obtain the first filtrate and the first filter residue, after the water stirring 10min of 4 times of its gross mass amounts is added into the first filtrate
The second filtrate is filtered to obtain, merges the first filtrate and the second filtrate is concentrated to give the first medicinal extract；
The last fresh Radix agastaches of portion are dried to that water content lower than 12%, obtains wrinkled giant hyssop cured leaf, by wrinkled giant hyssop cured leaf, mountain silver
Colored and panax mixed obtains Traditional Chinese drug mixture；
Step S2 is by Chinese traditional medicine composition extract, Agastache rugosa, medicinal extract, sweetener, acid, moisturizer, preservative, thin
Lotus alcohol and water are sufficiently mixed, packing to get.
Preferably, step S1 further include:
7-8 parts of Chinese prickly ash are weighed, the boiling boiling that 10 times of its gross mass amounts are added after claying into power is extracted 2 times, first time 2h, the
Secondary 1h merges the filtered fluid of 2 extractions, is concentrated to give the second medicinal extract；
2-5 parts of eupatorium are weighed, the boiling boiling that 10 times of its gross mass amounts are added after claying into power is extracted 2 times, first time 3h, the
Secondary 2h merges the filtered fluid of 2 extractions, is concentrated to give third medicinal extract, third medicinal extract carries out alcohol precipitation after being diluted with water, stirs and evenly mixs
2 hours are stood afterwards, the first alcohol precipitating is filtered to obtain, carries out alcohol precipitation after the first alcohol precipitating is dissolved in water, it is small that 2 are stood after stirring and evenly mixing
When, filter to obtain the second alcohol precipitating；
Step S2 is by Chinese traditional medicine composition extract, Agastache rugosa, the first medicinal extract, the second medicinal extract, the second alcohol precipitating, sweet taste
Agent, acid, moisturizer, preservative, menthol and water are sufficiently mixed, packing to get.
The present invention is include at least the following beneficial effects:
The first, addition includes the traditional Chinese medicine ingredients of wrinkled giant hyssop, Honeysuckle flower and Notogineng Extract in mouthwash, can effectively inhibit tooth
Bacterial plaque goes removing abnormal flavor in oral cavity, and the pre- preventing parodontitis of energy and gingivitis, and oral cavity caused by periodontitis, gingivitis is effectively relieved
Pain has the effect of good cleaning-nursing oral cavity；
The second, it is at low cost that Chinese medicine preparation contained by mouthwash is simple, raw material is easy to get, and Traditional Chinese drug mixture uses boiling twice, one
Secondary alcohol precipitation obtains Chinese traditional medicine composition extract, and preparation method is simple, and process stabilizing is produced on a large scale；
Third, the fresh Radix agastaches of raw material are carried out respectively cured leaf steam distillation obtain Agastache rugosa, fresh leaf mashing after it is cold
Freeze to extract and obtain the first medicinal extract and cooperation Radix Notoginseng and Honeysuckle flower water boiling and precipitation with ethanol acquisition Chinese traditional medicine composition extract, the leaves of pulse plants can be effectively increased
Wrinkled giant hyssop ketone, cinnaldehydrum etc. have the extracted amount of preferable antifungic action ingredient in perfume (or spice), improve mouthwash fungistatic effect, meanwhile, make
Agastache rugosa can volatilize on a small quantity in used time mouthwash enters human body by oral cavity, has stimulating gastrointestinal secretion, improves stomach cardia
Enzymatic activity effect promotes fresh breath, slows down the halitosis as caused by gastrointestinal disturbances；The addition of Chinese prickly ash and eupatorium, further matches
Wrinkled giant hyssop, Honeysuckle flower and Radix Notoginseng are closed, effectively improves mouthwash for the remission effect of oral cavity pain caused by gingivitis, periodontitis.
Further advantage, target and feature of the invention will be partially reflected by the following instructions, and part will also be by this
The research and practice of invention and be understood by the person skilled in the art.
Specific embodiment
The present invention will be further described in detail below with reference to the embodiments, to enable those skilled in the art referring to specification
Text can be implemented accordingly.
<embodiment 1>
Herbal mixture mouthwash, the raw material including following parts by weight:
12% Chinese traditional medicine composition extract, 0.01% Sucralose, 0.02% malic acid, 2% glycerol, 0.01% Metagin
The water of ester, 0.5% menthol and surplus, wherein the bulk pharmaceutical chemicals of Chinese medical extract include: 20 parts of wrinkled giant hyssop, 12 parts of Honeysuckle flower and
2 parts of Radix Notoginseng.
The preparation method of the herbal mixture mouthwash, comprising the following steps:
S1, wrinkled giant hyssop, Honeysuckle flower and panax mixed are weighed in proportion obtaining Traditional Chinese drug mixture, it is added into Traditional Chinese drug mixture
The boiling boiling of 15 times of gross mass amounts is extracted 2 times, first time 2h, second of 1.5h, is merged the filtered fluid of 2 extractions, is concentrated under reduced pressure
Concentrate (specific gravity at 80 DEG C is 1.05) is obtained, into concentrate plus ethyl alcohol makes alcohol content 60%, stands 24 after stirring and evenly mixing
Hour, it is filtered to remove and precipitates to obtain alcohol precipitation filtrate, alcohol precipitation filtrate is concentrated to give Chinese traditional medicine composition extract (specific gravity is 1.07 at 80 DEG C)；
S2, Chinese traditional medicine composition extract, Sucralose, malic acid, glycerol, methylparaben, menthol and water are sufficiently mixed
Close, packing to get.
<embodiment 2>
Herbal mixture mouthwash, the raw material including following parts by weight:
13% Chinese traditional medicine composition extract, 0.05% fructose, 0.06% citric acid, 6% sorbierite, 0.28% nipalgin second
The water of ester, 3.5% menthol and surplus, wherein the bulk pharmaceutical chemicals of Chinese medical extract include: 22 parts of wrinkled giant hyssop, 13 parts of Honeysuckle flower and
2.5 parts of Radix Notoginseng.
The preparation method of the herbal mixture mouthwash, comprising the following steps:
S1, wrinkled giant hyssop, Honeysuckle flower and panax mixed are weighed in proportion obtaining Traditional Chinese drug mixture, it is added into Traditional Chinese drug mixture
The boiling boiling of 15 times of gross mass amounts is extracted 2 times, first time 2h, second of 1.5h, is merged the filtered fluid of 2 extractions, is concentrated under reduced pressure
Concentrate (specific gravity at 80 DEG C is 1.06) is obtained, into concentrate plus ethyl alcohol makes alcohol content 60%, stands 24 after stirring and evenly mixing
Hour, it is filtered to remove and precipitates to obtain alcohol precipitation filtrate, alcohol precipitation filtrate is concentrated to give Chinese traditional medicine composition extract (specific gravity is 1.08 at 80 DEG C)；
S2, Chinese traditional medicine composition extract, fructose, citric acid, sorbierite, ethylparaben, menthol and water are sufficiently mixed
Close, packing to get.
<embodiment 3>
Herbal mixture mouthwash, the raw material including following parts by weight:
15% Chinese traditional medicine composition extract, 1% stevioside glycosides, 1% tartaric acid, 10% sorbierite, 0.4% sodium benzoate, 5%
The water of menthol and surplus, wherein the bulk pharmaceutical chemicals of Chinese medical extract include: 23 parts of wrinkled giant hyssop, 15 parts of Honeysuckle flower and 3 parts of Radix Notoginseng.
The preparation method of the herbal mixture mouthwash, comprising the following steps:
S1, wrinkled giant hyssop, Honeysuckle flower and panax mixed are weighed in proportion obtaining Traditional Chinese drug mixture, it is added into Traditional Chinese drug mixture
The boiling boiling of 15 times of gross mass amounts is extracted 2 times, first time 2h, second of 1.5h, is merged the filtered fluid of 2 extractions, is concentrated under reduced pressure
Concentrate (specific gravity at 80 DEG C is 1.10) is obtained, into concentrate plus ethyl alcohol makes alcohol content 60%, stands 24 after stirring and evenly mixing
Hour, it is filtered to remove and precipitates to obtain alcohol precipitation filtrate, alcohol precipitation filtrate is concentrated to give Chinese traditional medicine composition extract (specific gravity is 1.10 at 80 DEG C)；
S2, Chinese traditional medicine composition extract, stevioside glycosides, tartaric acid, sorbierite, sodium benzoate, menthol and water are sufficiently mixed
Close, packing to get.
<embodiment 4>
Herbal mixture mouthwash, the raw material including following parts by weight:
13% Chinese traditional medicine composition extract, 0.05% fructose, 0.06% citric acid, 6% sorbierite, 0.28% nipalgin second
The water of ester, 3.5% menthol and surplus, wherein the bulk pharmaceutical chemicals of Chinese medical extract include: 22 parts of wrinkled giant hyssop, 13 parts of Honeysuckle flower and
2.5 parts of Radix Notoginseng.
The preparation method of the herbal mixture mouthwash, comprising the following steps:
S1, wrinkled giant hyssop are fresh Radix agastaches, and fresh Radix agastaches are divided into three parts；
The fresh Radix agastaches of a copy of it carry out solarization night for three days on end it is bored be placed on 65 DEG C of drying in oven to constant weight after,
It clayed into power 100-200 mesh, and obtained Wrinkled Gianthyssop Herb, the water of 8 times of its gross mass amounts are added into Wrinkled Gianthyssop Herb, after impregnating 5h,
It carries out steam distillation and extracts 4h, obtain Agastache rugosa；
Another fresh Radix agastaches is beaten after the lemon juice of 0.05 times of its gross mass amount, 1 times of water measured is added, and obtains slurry,
Slurry is cooled to -20 DEG C, thaw at RT is taken out after keeping 3h, obtains freezing slurry, 2 times of its gross mass is added into freezing slurry
The water of amount filters to obtain the first filtrate and the first filter residue, after the water stirring 10min of 4 times of its gross mass amounts is added into the first filtrate
The second filtrate is filtered to obtain, merges the first filtrate and the second filtrate is concentrated to give the first medicinal extract；
The last fresh Radix agastaches of portion are dried to that water content is 11.5%, wrinkled giant hyssop cured leaf is obtained, weighs Honeysuckle flower in proportion
And Radix Notoginseng, wrinkled giant hyssop cured leaf, Honeysuckle flower and panax mixed are obtained into Traditional Chinese drug mixture, its gross mass 15 is added into Traditional Chinese drug mixture
The boiling boiling of amount is extracted 2 times, first time 2h, second of 1.5h again, merges the filtered fluids of 2 extractions, concentrate is concentrated under reduced pressure to obtain
(specific gravity at 80 DEG C is 1.03), into concentrate plus ethyl alcohol makes alcohol content 60%, stands 24 hours after stirring and evenly mixing, and filters
Removing precipitates to obtain alcohol precipitation filtrate, and alcohol precipitation filtrate is concentrated to give Chinese traditional medicine composition extract (specific gravity is 1.11 at 80 DEG C)；
S2, by Chinese traditional medicine composition extract, Agastache rugosa, the first medicinal extract, fructose, citric acid, sorbierite, ethylparaben,
Menthol and water are sufficiently mixed, packing to get.
<embodiment 5>
Herbal mixture mouthwash, the raw material including following parts by weight:
13% Chinese traditional medicine composition extract, 0.05% fructose, 0.06% citric acid, 6% sorbierite, 0.28% nipalgin second
The water of ester, 3.5% menthol and surplus, wherein the bulk pharmaceutical chemicals of Chinese medical extract include: 22 parts of wrinkled giant hyssop, 13 parts of Honeysuckle flower and
2.5 parts of Radix Notoginseng.
The preparation method of the herbal mixture mouthwash, comprising the following steps:
S1, wrinkled giant hyssop are fresh Radix agastaches, and fresh Radix agastaches are divided into three parts；
The fresh Radix agastaches of a copy of it carry out solarization night for three days on end it is bored be placed on 65 DEG C of drying in oven to constant weight after,
It clayed into power 100-200 mesh, and obtained Wrinkled Gianthyssop Herb, the water of 8 times of its gross mass amounts are added into Wrinkled Gianthyssop Herb, after impregnating 5h,
It carries out steam distillation and extracts 4h, obtain Agastache rugosa；
Another fresh Radix agastaches is beaten after the lemon juice of 0.05 times of its gross mass amount, 1 times of water measured is added, and obtains slurry,
Slurry is cooled to -20 DEG C, thaw at RT is taken out after keeping 3h, obtains freezing slurry, 2 times of its gross mass is added into freezing slurry
The water of amount filters to obtain the first filtrate and the first filter residue, after the water stirring 10min of 4 times of its gross mass amounts is added into the first filtrate
The second filtrate is filtered to obtain, merges the first filtrate and the second filtrate is concentrated to give the first medicinal extract；
The last fresh Radix agastaches of portion are dried to that water content is 10.9%, wrinkled giant hyssop cured leaf is obtained, weighs Honeysuckle flower in proportion
And Radix Notoginseng, wrinkled giant hyssop cured leaf, Honeysuckle flower and panax mixed are obtained into Traditional Chinese drug mixture, its gross mass 15 is added into Traditional Chinese drug mixture
The boiling boiling of amount is extracted 2 times, first time 2h, second of 1.5h again, merges the filtered fluids of 2 extractions, concentrate is concentrated under reduced pressure to obtain
(specific gravity at 80 DEG C is 1.09), into concentrate plus ethyl alcohol makes alcohol content 60%, stands 24 hours after stirring and evenly mixing, and filters
Removing precipitates to obtain alcohol precipitation filtrate, and alcohol precipitation filtrate is concentrated to give Chinese traditional medicine composition extract (specific gravity is 1.10 at 80 DEG C)；
7-8 parts of Chinese prickly ash are weighed, the boiling boiling that 10 times of its gross mass amounts are added after claying into power is extracted 2 times, first time 2h, the
Secondary 1h merges the filtered fluid of 2 extractions, is concentrated to give the second medicinal extract；
2-5 parts of eupatorium are weighed, the boiling boiling that 10 times of its gross mass amounts are added after claying into power is extracted 2 times, first time 3h, the
Secondary 2h merges the filtered fluid of 2 extractions, is concentrated to give third medicinal extract, third medicinal extract carries out alcohol precipitation after being diluted with water, stirs and evenly mixs
2 hours are stood afterwards, the first alcohol precipitating is filtered to obtain, carries out alcohol precipitation after the first alcohol precipitating is dissolved in water, it is small that 2 are stood after stirring and evenly mixing
When, filter to obtain the second alcohol precipitating；
S2, by Chinese traditional medicine composition extract, Agastache rugosa, the first medicinal extract, the second medicinal extract, the second alcohol precipitating, fructose, lemon
Acid, sorbierite, ethylparaben, menthol and water are sufficiently mixed, packing to get.
Experiment
1, acute toxic test
It will be concentrated into constant weight as made from embodiment 5, and be dissolved in water the suspension that 0.5g/mL is made, and choose mouse
It male female each 10, gavages, feeds administration according to 10g (bulk pharmaceutical chemicals)/kg (mice weights) dosage, observe 72h after feeding
It has no dead mouse and exception, shows that dosis tolerata is big.
2, antibacterial test (bacterium of use is international standard strain)
2.1, bacterial species: staphylococcus aureus, Candida albicans, streptococcus mutans, Bacillus acidi lactici, porphyromonas list
Born of the same parents bacterium.
2.2, prepared by bacteria culture media
Solid medium: weighing 30g Tryptose soy meat soup, base agar 15g is added, with 1000mL, 100 DEG C of purifying
Completely, 120 DEG C, 110kpa high pressure steam sterilization 20min are cooled to 50-60 DEG C, and constant temperature saves, spare for water dissolution；
Fluid nutrient medium: weighing 6g Tryptose soy meat soup, is dissolved completely with 200mL, 100 DEG C of purified water, 120 DEG C,
110kpa high pressure steam sterilization 20min is cooled to 50-60 DEG C, and constant temperature saves, spare；
2.3, (diffusion method) is tested
Blank control group: purified water (is cooled to room temperature) after high pressure sterilization
Take 5 groups (group 1, group 2, group 3, group 4, group 5) be equipped with solid medium culture dishes, every group 5, by fluid nutrient medium
It is uniformly applied on the culture medium of each culture dish, the ((inoculation of group 1 of bacterium in inoculation above-mentioned 5 is respectively corresponded on rear every group of culture dish
Staphylococcus aureus), group 2 (inoculation Candida albicans), group 3 (inoculation streptococcus mutans), 4 (inoculating lactobacillus) of group, group 5
(inoculation porphyromonas gingivalis)), it is placed in 37 DEG C of constant temperature incubator and cultivates for 24 hours, obtain cultivation culture dish；
Each 50mg of purified water for weighing the mouthwash and blank control group of embodiment 1-4 preparation, respectively with the capillary of 10 μ L
Dropper equivalent drop is on 15 roundlet filter papers, then by roundlet filter paper according to symmetrically attaching 3 in each cultivation culture dish
A (containing mouthwash of the same race or blank control group), wherein mouthwash of the same race or 15 roundlet filter papers of blank control group are with 3
A 5 (including one in every group of cultivation culture dish) uniformly attached in 5 groups of cultivation culture dishes respectively for a small group, Mei Gepei
Educate the middle section for being attached at culture medium in corresponding cultivation culture dish of 3 in culture dish roundlet filter papers symmetrically；
The cultivation culture dish for being pasted with sequin is placed in 37 DEG C of constant incubator after cultivating for 24 hours, measures each training
It supports the diameter of three similar round antibacterial regions in ware and is averaged, specific such as table 1:
1 antibacterial region average diameter of table
Antibacterial test is carried out using diffusion method, if counter sample has antibiotic property, antibacterial can be shown on culture medium
Sample antibiotic property is assessed in region by the diameter of antibacterial region, and diameter is bigger, and expression antibiotic property is stronger.Wherein, golden yellow
Color staphylococcus, Candida albicans, streptococcus mutans, Bacillus acidi lactici, porphyromonas gingivalis are oral cavity common bacteria, golden yellow
Staphylococcus is a kind of Gram-negative coccus, is often piled into thyrsiform, Yi Yinfa oral inflammation, and Candida albicans is a kind of
Fungi, is typically found in normal human mouth, and the upper respiratory tract easily invades cell and cause disease, become when body's immunity decline
Shape streptococcus is the main pathogenic bacteria of one of main component of plaque and dental caries, and dental caries betide hard tooth tissue
Bacterial infection disease, the disease incidence highest in mouth disease, Bacillus acidi lactici refer to the bacterium that carbohydrate fermentation can be made to generate lactic acid,
Lactobacillus fermentation sugar generates a large amount of lactic acid, easily causes cavity, porphyromonas gingivalis is a kind of gram-negative of non-glycolysis sugar
Property anaerobism coccobacillus, is one of Periodontal Pathogens, and porphyromonas gingivalis is once out of control, be will lead under gum falls off from tooth
Come.
As shown in Table 1, blank control group (purified water) does not show antibacterial region, and the mouthwash pair of embodiment 1-3 preparation
This 5 kinds of common bacterias of staphylococcus aureus, Candida albicans, streptococcus mutans, Bacillus acidi lactici, porphyromonas gingivalis generate
Apparent antibacterial region, embodiment 4 are substantially better than embodiment 1- for the inhibitory effect of staphylococcus aureus, Candida albicans
3, main reason is that in embodiment 4 by the fresh Radix agastaches of raw material carry out respectively cured leaf steam distillation obtain Agastache rugosa,
Freezing, which is extracted, after fresh leaf mashing obtains the first medicinal extract and Radix Notoginseng and Honeysuckle flower water boiling and precipitation with ethanol is cooperated to obtain Chinese traditional medicine composition extract,
The extracted amount that wrinkled giant hyssop ketone, cinnaldehydrum etc. in wrinkled giant hyssop have preferable antifungic action ingredient can be effectively increased, improve mouthwash for
Staphylococcus aureus, Candida albicans fungistatic effect.
3, clinical observation
3.1, using opinion poll point system
Choose 40 is caused the patient of gum pain to be experimental subjects by gingivitis, is randomly divided into 2 groups of (including experimental groups 1
With experimental group 2, every group of 20 people), mouthwash is used after the meal and before sleep three for each person every day, wherein experimental group 1 uses embodiment
The mouthwash of 1 preparation, the mouthwash that experimental group 2 is prepared using embodiment 5, the application method of mouthwash are as follows: 15-20mL gargles
Water keeps in the mouth, and two cheeks and lip is agitated to keep 40s, so that mouthwash can be contacted sufficiently with tooth, gum in the oral cavity, and anti-
The each position in oral cavity, and not diet in 30min are rinsed again.
2 days as a treatment course record and count gum pain symptom and alleviate situation, specific such as table 2:
2 gingivitis of table causes gum pain symptom to alleviate situation
As shown in Table 2, mouthwash prepared by the mouthwash and embodiment 5 that prepared by embodiment 1, which can alleviate gingivitis, to be caused
Oral cavity pain sense, wherein the remission effect of embodiment 5 be better than embodiment 1.
3.3, using opinion poll point system
Choose 40 is caused the patient of gum pain to be experimental subjects by periodontitis, is randomly divided into 2 groups of (including experimental groups 1
With experimental group 2, every group of 20 people), mouthwash is used after the meal and before sleep three, wherein is made on the basis of 1 oral anti-inflammatory drug of experimental group
With physiological saline, the mouthwash that experimental group 2 is prepared on the basis of oral anti-inflammatory drug using embodiment 5 and is gargled at physiological saline
The application method of water are as follows: 15-20mL mouthwash or physiological saline keep in the mouth, agitate two cheeks and lip to keep 40s, so as to gargle
Saliva or physiological saline can be contacted sufficiently with tooth, gum in the oral cavity, and each position in repeated flushing oral cavity, and in 30min
Not diet.
1 days as a treatment course record and count gum pain symptom and alleviate situation, specific such as table 2:
2 periodontitis of table causes gum pain symptom to alleviate situation
| Use number of days | Experimental group 1 | Experimental group 2 |
| 1 | 12 human mouth feeling of pains are alleviated | 4 human mouth feeling of pains are obviously improved |
| 2 | 4 human mouth feeling of pains are obviously improved | 7 human mouth feeling of pains are obviously improved |
| 3 | 6 human mouth feeling of pains are obviously improved | 12 human mouth feeling of pains are obviously improved |
As shown in Table 3: for patients with periodontitis oral anti-inflammatory drug, and with the use of embodiment 5 prepare mouthwash for
The remission effect of oral cavity pain is used cooperatively physiological saline better than oral anti-inflammatory drug.
Although the embodiments of the present invention have been disclosed as above, but its is not only in the description and the implementation listed
With it can be fully applied to various fields suitable for the present invention, for those skilled in the art, can be easily
Realize other modification, therefore without departing from the general concept defined in the claims and the equivalent scope, the present invention is simultaneously unlimited
In specific details and embodiment shown and described herein.
Claims (7)
1. herbal mixture mouthwash, which is characterized in that the raw material including following parts by weight:
12-15% Chinese traditional medicine composition extract, 0.01-1% sweetener, 0.02-1% acid, 2-10% moisturizer, 0.01-
The water of 0.4% preservative, 0.5-5% menthol and surplus, wherein the bulk pharmaceutical chemicals of Chinese medical extract include: 20-23 parts of wrinkled giant hyssop,
12-15 parts of Honeysuckle flower and 2-3 parts of Radix Notoginseng.
2. herbal mixture mouthwash as described in claim 1, which is characterized in that the bulk pharmaceutical chemicals of Chinese medical extract further include: flower
7-8 parts of green pepper, 2-5 parts of eupatorium.
3. herbal mixture mouthwash as described in claim 1, which is characterized in that sweetener is Sucralose, fructose, STEVIA REBAUDIANA
One or more of glycosides, acid are one of malic acid, citric acid, tartaric acid, and moisturizer is glycerol, in sorbierite
One kind, preservative are one or more of methylparaben, ethylparaben, sodium benzoate.
4. the preparation method of herbal mixture mouthwash as described in claim 1, which comprises the following steps:
S1, wrinkled giant hyssop, Honeysuckle flower and panax mixed are weighed in proportion obtaining Traditional Chinese drug mixture, its total matter is added into Traditional Chinese drug mixture
The boiling boiling for measuring 15 times of amounts is extracted 2 times, first time 2h, second of 1.5h, is merged the filtered fluid of 2 extractions, is concentrated under reduced pressure dense
Contracting liquid, into concentrate plus ethyl alcohol makes alcohol content 60%, stands 24 hours after stirring and evenly mixing, and is filtered to remove and precipitates to obtain alcohol precipitation filter
Liquid, alcohol precipitation filtrate are concentrated to give Chinese traditional medicine composition extract；
S2, Chinese traditional medicine composition extract, sweetener, acid, moisturizer, preservative, menthol and water are sufficiently mixed, are dispensed,
To obtain the final product.
5. the preparation method of herbal mixture mouthwash as claimed in claim 4, which is characterized in that 80 DEG C of concentrate in step S1
When specific gravity be 1.02-1.10, specific gravity is 1.06-1.12 at 80 DEG C of Chinese traditional medicine composition extract.
6. the preparation method of herbal mixture mouthwash as claimed in claim 4, which is characterized in that wrinkled giant hyssop is fresh Radix agastaches,
Fresh Radix agastaches are divided into three parts in step S1；
The fresh Radix agastaches of a copy of it carry out continuous 3-4 days solarization night it is bored be placed on 65 DEG C of drying in oven to constant weight after, mill
100-200 mesh is crossed at powder, obtains Wrinkled Gianthyssop Herb, the water of 8 times of its gross mass amounts is added into Wrinkled Gianthyssop Herb, after impregnating 5h, into
Row steam distillation extracts 4h, obtains Agastache rugosa；
Another fresh Radix agastaches is beaten after the lemon juice of 0.05 times of its gross mass amount, 1 times of water measured is added, and is obtained slurry, will be starched
Material is cooled to -20 DEG C, takes out thaw at RT after keeping 3h, obtains freezing slurry, and 2 times of its gross mass amounts are added into freezing slurry
Water filters to obtain the first filtrate and the first filter residue, filters after the water stirring 10min of 4 times of its gross mass amounts is added into the first filtrate
The second filtrate is obtained, merges the first filtrate and the second filtrate is concentrated to give the first medicinal extract；
The last fresh Radix agastaches of portion are dried to that water content lower than 12%, obtains wrinkled giant hyssop cured leaf, by wrinkled giant hyssop cured leaf, Honeysuckle flower and
Panax mixed obtains Traditional Chinese drug mixture；
Step S2 is by Chinese traditional medicine composition extract, Agastache rugosa, medicinal extract, sweetener, acid, moisturizer, preservative, peppermint
Alcohol and water are sufficiently mixed, packing to get.
7. the preparation method of herbal mixture mouthwash as claimed in claim 6, which is characterized in that step S1 further include:
7-8 parts of Chinese prickly ash are weighed, the boiling boiling that 10 times of its gross mass amounts are added after claying into power is extracted 2 times, first time 2h, and second
1h merges the filtered fluid of 2 extractions, is concentrated to give the second medicinal extract；
2-5 parts of eupatorium are weighed, the boiling boiling that 10 times of its gross mass amounts are added after claying into power is extracted 2 times, first time 3h, and second
2h merges the filtered fluid of 2 extractions, is concentrated to give third medicinal extract, third medicinal extract carries out alcohol precipitation after being diluted with water, and stirs and evenly mixs rear quiet
It sets 2 hours, filters to obtain the first alcohol precipitating, carry out alcohol precipitation after the first alcohol precipitating is dissolved in water, stand 2 hours after stirring and evenly mixing,
Filter to obtain the second alcohol precipitating；
Step S2 is by Chinese traditional medicine composition extract, Agastache rugosa, the first medicinal extract, the second medicinal extract, the second alcohol precipitating, sweetener, acid
Taste agent, moisturizer, preservative, menthol and water are sufficiently mixed, packing to get.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110123723A (en) * | 2019-06-25 | 2019-08-16 | 福建省农业科学院亚热带农业研究所（福建省农业科学院蔗麻研究中心） | A kind of Garbo fruit blade mouthwash of pre- antiplaque and preparation method thereof |
| CN110433117A (en) * | 2019-08-30 | 2019-11-12 | 武汉品瑞医学科技有限公司 | Mouthwash and preparation method thereof |
| CN114376956A (en) * | 2022-02-24 | 2022-04-22 | 四川天福精细化工有限公司 | Spray mouth wash and preparation method thereof |
| CN114601780A (en) * | 2022-03-30 | 2022-06-10 | 中国药科大学 | Anti-inflammatory and antibacterial traditional Chinese medicine compound mouthwash and preparation method thereof |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101416929A (en) * | 2008-12-08 | 2009-04-29 | 曹婷 | Gargle |
| CN106309210A (en) * | 2016-06-12 | 2017-01-11 | 广州市海诗生物科技有限公司 | Chinese herbal medicine mouth wash and preparation method thereof |
| CN106309670A (en) * | 2015-07-02 | 2017-01-11 | 樊新民 | Method for preparing medicine for treating toothache |
| CN107303249A (en) * | 2016-04-20 | 2017-10-31 | 新疆中草堂医药科技有限公司 | A kind of compound lavender aromatic mouthwass |
| CN108186441A (en) * | 2018-02-10 | 2018-06-22 | 广州市九科精细化工有限公司 | A kind of antianaphylactic compound herbal mouthwash of hemostasis and preparation method thereof |
| CN109223637A (en) * | 2018-10-23 | 2019-01-18 | 缪剑华 | Subprostrate sophora herbal mixture toothpaste and preparation method |
-
2019
- 2019-01-21 CN CN201910054886.0A patent/CN109528601B/en not_active Expired - Fee Related
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101416929A (en) * | 2008-12-08 | 2009-04-29 | 曹婷 | Gargle |
| CN106309670A (en) * | 2015-07-02 | 2017-01-11 | 樊新民 | Method for preparing medicine for treating toothache |
| CN107303249A (en) * | 2016-04-20 | 2017-10-31 | 新疆中草堂医药科技有限公司 | A kind of compound lavender aromatic mouthwass |
| CN106309210A (en) * | 2016-06-12 | 2017-01-11 | 广州市海诗生物科技有限公司 | Chinese herbal medicine mouth wash and preparation method thereof |
| CN108186441A (en) * | 2018-02-10 | 2018-06-22 | 广州市九科精细化工有限公司 | A kind of antianaphylactic compound herbal mouthwash of hemostasis and preparation method thereof |
| CN109223637A (en) * | 2018-10-23 | 2019-01-18 | 缪剑华 | Subprostrate sophora herbal mixture toothpaste and preparation method |
Non-Patent Citations (2)
| Title |
|---|
| 刘勇谋: "《现代家庭营养大全》", 31 March 2006, 湖北科学技术出版社 * |
| 彭芳胜: "《土家医毒气病学》", 30 June 2014, 中医古籍出版社 * |
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| CN110123723A (en) * | 2019-06-25 | 2019-08-16 | 福建省农业科学院亚热带农业研究所（福建省农业科学院蔗麻研究中心） | A kind of Garbo fruit blade mouthwash of pre- antiplaque and preparation method thereof |
| CN110433117A (en) * | 2019-08-30 | 2019-11-12 | 武汉品瑞医学科技有限公司 | Mouthwash and preparation method thereof |
| CN114376956A (en) * | 2022-02-24 | 2022-04-22 | 四川天福精细化工有限公司 | Spray mouth wash and preparation method thereof |
| CN114601780A (en) * | 2022-03-30 | 2022-06-10 | 中国药科大学 | Anti-inflammatory and antibacterial traditional Chinese medicine compound mouthwash and preparation method thereof |
| CN114601780B (en) * | 2022-03-30 | 2023-10-24 | 中国药科大学 | Anti-inflammatory antibacterial traditional Chinese medicine compound mouthwash and preparation method thereof |
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