CN104940438A - Chinese herbal medicine extract and toothpaste for preventing and treating childhood caries, and application of Chinese herbal medicine extract - Google Patents
Chinese herbal medicine extract and toothpaste for preventing and treating childhood caries, and application of Chinese herbal medicine extract Download PDFInfo
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Abstract
The invention relates to the technical field of Chinese herbal medicines, in particular to a Chinese herbal medicine extract and toothpaste for preventing and treating childhood caries, and an application of the Chinese herbal medicine extract. The Chinese herbal medicine extract is prepared by pretreating, grinding, ultrasonically extracting and filtering traditional Chinese medicinal materials such as sculellaria barbata, folium callicarpae pedunculatae, lucid ganoderma, sweet-scented osmanthus, fructus piperis longi, bearded mallotus leaf, flos chrysanthemi indici, shrubby baeckea and acanthopanax. Compared with the prior art, the herbal medicine extract can significantly inhibit generation of oral anaerobic bacteria, has effects of clearing heat and easing a pain, has significant curative effects on preventing and treating the childhood caries and alleviating the pain caused by the caries, has no side effect, is high in safety, and is worthy of clinical popularization. The Chinese herbal medicine extract has the advantages that raw materials are easy to obtain; a preparation method is simple; and the cost is lower. The Chinese herbal medicine extract can be used for preparing an agent, food or a daily necessity for preventing and treating the childhood caries.
Description
Technical field
The present invention relates to field of Chinese herbal medicine technology, be specifically related to a kind of application of Chinese herbal medicine extract, toothpaste and the Chinese herbal medicine extract of preventing and treating children caries.
Background technology
Dental caries is commonly called as dental caries, decayed tooth, is bacterial disease, can secondary pulpitis and periapical periodontitis, even can cause alveolar bone and inflammation of jaws.As treated not in time, pathological changes continues development, forms cavity, destroys disappearance completely, even loss of tooth to corona eventually.Dental caries feature is that sickness rate is high, and distribution is wide, and be the main commonly encountered diseases in oral cavity, itself and tumor and cardiovascular disease are listed as the mankind three keypoint control disease greatly by World Health Organization (WHO).
Child is owing to being in the stage of growth promoter, and tooth is changed relatively more frequent, and the protection coating of dental surface also immaturity, children's enjoys a lot to eat sweet food in addition, and therefore, the ratio suffering from dental caries in child is very high.There is the harm that dental caries causes in child, can affect the growth of dentognathic system, cause acquired deformity.The pain of dental caries can affect the feed of child, cause and dare not chew with ill tooth, food does not enter in stomach through peruse, makes food can not be complete in gastric digestion, thus have influence on the absorption of small intestinal to nutrition, the body constitution of child can be reduced for a long time; If dental caries is not got timely medical treatment, also can further develop the inflammation around the inflammation causing dental pulp and apex of root of tooth, the pain caused is difficult to stand; In addition, because pain, Maxillary region growth promoter can be had influence on one-sided eating for a long time, even cause bashful deformity of being bold, therefore, for the generation additional important of child's prevention and therapy dental caries.
The essential condition that dental caries occurs, it is generally acknowledged that cariogenic bacteria has two types, and one is that acid-producing bacteria belongs to, and is wherein mainly Streptococcus mutans, actinomyces and lactobacillus, carbohydrate breakdown can be made to produce acid, cause the demineralization of tooth inanimate matter; Another kind is gram positive coccus, can destruction of organic material, tooth can be made to form cavity through long term.In prior art, some antibacterial are usually adopted to prevent and treat dental caries.But, life-time service broad spectrum antimicrobicide can destroy the ecological balance in oral cavity and may occur various bad side effect, and, antibiotics topical application is easy to produce drug resistance, long-term topical application also can cause dysbacteriosis and fungal infection, and child is particularly evident on its impact after using.
For solving the problems of the technologies described above, in recent years, application in TCM is started in the pharmacology of prevention and therapy dental caries and the research of mechanism the concern and the attention that are subject to Chinese scholars, need badly development a kind of for child's prevention and therapy dental caries and have no side effect, the Chinese herbal medicine extract of good antimicrobial effect.
Summary of the invention
An object of the present invention is for the deficiencies in the prior art, provide a kind of suppress oral cavity bacterium effective, have no side effect, be easy to the Chinese herbal medicine extract of control children caries prepared.
Two of object of the present invention is for the deficiencies in the prior art, provide a kind of suppress oral cavity bacterium effective, have no side effect, be easy to prepare, the preparation method of the Chinese herbal medicine extract of control children caries that cost is low.
Three of object of the present invention is for the deficiencies in the prior art, provide a kind of suppress oral cavity bacterium effective, have no side effect, be easy to prepare, the toothpaste of control children caries that cost is low.
Four of object of the present invention is for the deficiencies in the prior art, provides a kind of application of Chinese herbal medicine extract.
To achieve these goals, the present invention adopts following technical scheme:
A kind of Chinese herbal medicine extract preventing and treating children caries is provided, is made up of the raw material of following weight portion:
Herba Scutellariae Barbatae 12 ~ 20 parts;
Folium Callicarpae Formosanae 30 ~ 40 parts;
Ganoderma 12 ~ 18 parts;
Flos Osmanthi Fragrantis 10 ~ 15 parts;
Fructus Piperis Longi 5 ~ 15 parts;
Radix seu Folium Alchorneae trewioidis 8 ~ 15 parts;
Flos Chrysanthemi Indici 8 ~ 15 parts;
Folium Baeckeae 6 ~ 12 parts;
Radix Et Caulis Acanthopanacis Senticosi 6 ~ 12 parts.
Preferably, described a kind of Chinese herbal medicine extract preventing and treating children caries, be made up of the raw material of following weight portion:
Herba Scutellariae Barbatae 15 parts;
Folium Callicarpae Formosanae 35 parts;
Ganoderma 13 parts;
Flos Osmanthi Fragrantis 12 parts;
Fructus Piperis Longi 8 parts;
Radix seu Folium Alchorneae trewioidis 10 parts;
Flos Chrysanthemi Indici 10 parts;
Folium Baeckeae 9 parts;
Radix Et Caulis Acanthopanacis Senticosi 10 parts.
Preferably, described a kind of Chinese herbal medicine extract preventing and treating children caries, be made up of the raw material of following weight portion:
Herba Scutellariae Barbatae 18 parts;
Folium Callicarpae Formosanae 32 parts;
Ganoderma 15 parts;
Flos Osmanthi Fragrantis 15 parts;
Fructus Piperis Longi 10 parts;
Radix seu Folium Alchorneae trewioidis 10 parts;
Flos Chrysanthemi Indici 12 parts;
Folium Baeckeae 7 parts;
Radix Et Caulis Acanthopanacis Senticosi 8 parts.
The present invention also provides a kind of preparation method of preventing and treating the Chinese herbal medicine extract of children caries, comprises the following steps:
(1) pretreatment:
Get the raw material of formula ratio, after cleaning, through 40 ~ 60 DEG C of drying 10 ~ 16 h;
(2) grind:
Ground by raw material after drying, sieve after pulverizing through 45 ~ 200 orders, obtain powder mixture, cold preservation is for subsequent use;
(3) ultrasonic extraction:
The powder mixture that step (2) obtains is put into the extraction pot of sealing, then the pure water of 7 ~ 10 times amount of powder mixture weight is added, soak 3 ~ 5h, ultrasonic extraction is carried out under 40 ~ 50 DEG C of conditions, supersonic frequency is 30 ~ 60kHZ, and at interval of 5min ultrasonication once, each ultrasonication time is 3min, total extraction time is 25 ~ 40min, obtains extracting solution;
(4) filter:
Extracting solution cooling step (3) obtained, collecting by filtration filtrate, after filtrate sterilizing, obtain the Chinese herbal medicine extract of described control children caries.
The present invention also provides a kind of toothpaste preventing and treating children caries, is made up of the raw material of following weight portion:
Chinese herbal medicine extract 5 ~ 10 parts;
Sorbitol 110 ~ 135 parts;
Silicon dioxide 30 ~ 40 parts;
0.3 ~ 1 part, glucide;
0.1 ~ 0.3 part, essence;
Xanthan gum 0.5 ~ 2.5 part;
PEG400 3 ~ 8 parts;
Antiseptic 0.01 ~ 0.05 part;
Herba Menthae 0.5 ~ 2 part;
Sodium lauryl sulphate 1 ~ 4 part;
Described Chinese herbal medicine extract is the Chinese herbal medicine extract adopting said method to prepare;
The preparation method of described toothpaste is as follows:
By formula ratio, Chinese herbal medicine extract, sorbitol, silicon dioxide, glucide, essence, Herba Menthae are added in hermetically sealed can, be heated to 40 ~ 50 DEG C, stir while add the xanthan gum of formula ratio, Polyethylene Glycol, sodium lauryl sulphate and antiseptic, mixture is obtained after stirring, then mixture is cooled to room temperature, inspect by random samples qualified after carry out fill, namely obtain described toothpaste.
Preferably, described a kind of toothpaste preventing and treating children caries, be made up of the raw material of following weight portion:
Chinese herbal medicine extract 8 parts;
Sorbitol 120 parts;
Silicon dioxide 36 parts;
0.5 part, glucide;
0.1 part, essence;
Xanthan gum 1 part;
PEG400 5 parts;
Antiseptic 0.02 part;
Herba Menthae 1 part;
Sodium lauryl sulphate 1 part.
The present invention also provides Chinese herbal medicine extract preparing the application in medicament, food or the article of everyday use preventing and treating children caries, and described Chinese herbal medicine extract is the Chinese herbal medicine extract of above-mentioned control children caries.
Preferably, the dosage form of described medicament is tablet, unguentum or spray.
Preferably, the classification of described food is chewing gum, buccal tablet or chewing gum sugar.
Preferably, the classification of described article of everyday use is toothpaste, dentifrice, mouthwash or oral spray.
the invention has the beneficial effects as follows:
At the Chinese herbal medicine extract preventing children caries of the present invention, according to the prescription compatibility theory of Chinese medicine " monarch, minister, help, make ", wherein Herba Scutellariae Barbatae, Folium Callicarpae Formosanae are monarch drug, Ganoderma, Flos Osmanthi Fragrantis, Radix seu Folium Alchorneae trewioidis are ministerial drug, Fructus Piperis Longi, Folium Baeckeae are adjuvant drug, Flos Chrysanthemi Indici, Radix Et Caulis Acanthopanacis Senticosi are for making medicine, synergism between above-mentioned various Chinese herbal medicine, interact, complement each other, play the merit of monarch altogether, made Chinese herbal medicine extract significantly can suppress the generation of oral cavity anaerobium, and there is effect of clearing away heat and alleviating pain, it has significant curative effect for preventing and treating children caries and alleviating the pain aspect caused due to dental caries, and be free from side effects, safety is high, clinic is promoted, and Chinese herbal medicine extract of the present invention have raw material be easy to obtain, preparation method is simple, lower-cost advantage, can be used for the medicament preparing control children caries, the article of everyday use such as food or toothpaste, thus there is wide market prospect and using value.
Detailed description of the invention
The invention will be further described with the following Examples.
embodiment 1.
Prevent and treat a Chinese herbal medicine extract for children caries, be made up of the raw material of following weight portion:
Herba Scutellariae Barbatae 15 parts;
Folium Callicarpae Formosanae 35 parts;
Ganoderma 13 parts;
Flos Osmanthi Fragrantis 12 parts;
Fructus Piperis Longi 8 parts;
Radix seu Folium Alchorneae trewioidis 10 parts;
Flos Chrysanthemi Indici 10 parts;
Folium Baeckeae 9 parts;
Radix Et Caulis Acanthopanacis Senticosi 10 parts.
Preparation method is as follows:
(1) pretreatment:
Get the raw material of formula ratio, after cleaning, through 45 DEG C of drying 12 h;
(2) grind:
Ground by raw material after drying, sieve after pulverizing through 120 orders, obtain powder mixture, cold preservation is for subsequent use;
(3) ultrasonic extraction:
The powder mixture that step (2) obtains is put into the extraction pot of sealing, then the pure water of 8 times amount of powder mixture weight is added, soak 3h, ultrasonic extraction is carried out under 45 DEG C of conditions, supersonic frequency is 50kHZ, and at interval of 5min ultrasonication once, each ultrasonication time is 3min, total extraction time is 40min, obtains extracting solution;
(4) filter:
Extracting solution cooling step (3) obtained, collecting by filtration filtrate, after filtrate sterilizing, obtain the Chinese herbal medicine extract of described control children caries.
embodiment 2.
Prevent and treat a Chinese herbal medicine extract for children caries, be made up of the raw material of following weight portion:
Herba Scutellariae Barbatae 18 parts;
Folium Callicarpae Formosanae 32 parts;
Ganoderma 15 parts;
Flos Osmanthi Fragrantis 15 parts;
Fructus Piperis Longi 10 parts;
Radix seu Folium Alchorneae trewioidis 10 parts;
Flos Chrysanthemi Indici 12 parts;
Folium Baeckeae 7 parts;
Radix Et Caulis Acanthopanacis Senticosi 8 parts.
Preparation method is as follows:
(1) pretreatment:
Get the raw material of formula ratio, after cleaning, through 55 DEG C of drying 10 h;
(2) grind:
Ground by raw material after drying, sieve after pulverizing through 100 orders, obtain powder mixture, cold preservation is for subsequent use;
(3) ultrasonic extraction:
The powder mixture that step (2) obtains is put into the extraction pot of sealing, then the pure water of 8 times amount of powder mixture weight is added, soak 4h, ultrasonic extraction is carried out under 45 DEG C of conditions, supersonic frequency is 45kHZ, and at interval of 5min ultrasonication once, each ultrasonication time is 3min, total extraction time is 32min, obtains extracting solution;
(4) filter:
Extracting solution cooling step (3) obtained, collecting by filtration filtrate, after filtrate sterilizing, obtain the Chinese herbal medicine extract of described control children caries.
embodiment 3.
Prevent and treat a Chinese herbal medicine extract for children caries, be made up of the raw material of following weight portion:
Herba Scutellariae Barbatae 20 parts;
Folium Callicarpae Formosanae 38 parts;
Ganoderma 15 parts;
Flos Osmanthi Fragrantis 10 parts;
Fructus Piperis Longi 12 parts;
Radix seu Folium Alchorneae trewioidis 12 parts;
Flos Chrysanthemi Indici 15 parts;
Folium Baeckeae 12 parts;
Radix Et Caulis Acanthopanacis Senticosi 9 parts.
Preparation method is as follows:
(1) pretreatment:
Get the raw material of formula ratio, after cleaning, through 50 DEG C of drying 15 h;
(2) grind:
Ground by raw material after drying, sieve after pulverizing through 80 orders, obtain powder mixture, cold preservation is for subsequent use;
(3) ultrasonic extraction:
The powder mixture that step (2) obtains is put into the extraction pot of sealing, then the pure water of 8 times amount of powder mixture weight is added, soak 3.5h, ultrasonic extraction is carried out under 40 DEG C of conditions, supersonic frequency is 45kHZ, and at interval of 5min ultrasonication once, each ultrasonication time is 3min, total extraction time is 32min, obtains extracting solution;
(4) filter:
Extracting solution cooling step (3) obtained, collecting by filtration filtrate, after filtrate sterilizing, obtain the Chinese herbal medicine extract of described control children caries.
embodiment 4.
Prevent and treat a toothpaste for children caries, be made up of the raw material of following weight portion:
Chinese herbal medicine extract 8 parts;
Sorbitol 120 parts;
Silicon dioxide 36 parts;
0.5 part, glucide;
0.1 part, essence;
Xanthan gum 1 part;
PEG400 5 parts;
Antiseptic 0.02 part;
Herba Menthae 1 part;
Sodium lauryl sulphate 1 part;
The preparation method of said herbal medicine extract and the identical of embodiment 1.
The preparation method of toothpaste is as follows:
By formula ratio, Chinese herbal medicine extract, sorbitol, silicon dioxide, glucide, essence, Herba Menthae are added in hermetically sealed can, be heated to 40 DEG C, stir while add the xanthan gum of formula ratio, Polyethylene Glycol, sodium lauryl sulphate and antiseptic, mixture is obtained after stirring, then mixture is cooled to room temperature, inspect by random samples qualified after carry out fill, namely obtain described toothpaste.
embodiment 5.
Prevent and treat a toothpaste for children caries, be made up of the raw material of following weight portion:
Chinese herbal medicine extract 10 parts;
Sorbitol 130 parts;
Silicon dioxide 32 parts;
0.8 part, glucide;
0.15 part, essence;
Xanthan gum 1.5 parts;
PEG400 6 parts;
Antiseptic 0.02 part;
Herba Menthae 1 part;
Sodium lauryl sulphate 1.5 parts.
The preparation method of said herbal medicine extract and the identical of embodiment 2.
The preparation method of toothpaste is as follows:
By formula ratio, Chinese herbal medicine extract, sorbitol, silicon dioxide, glucide, essence, Herba Menthae are added in hermetically sealed can, be heated to 45 DEG C, stir while add the xanthan gum of formula ratio, Polyethylene Glycol, sodium lauryl sulphate and antiseptic, mixture is obtained after stirring, then mixture is cooled to room temperature, inspect by random samples qualified after carry out fill, namely obtain described toothpaste.
experimental example 1: the In Vitro Bacteriostatic of cariogenic bacteria is studied.
Streptococcus mutans, actinomyces viscosus are considered to most important cariogenic bacteria, and they form dental plaque by the adhesion to facing, making tooth produce dental caries bad, therefore suppressing and kill cariogenic bacteria to have important effect to preventing and treating dental caries.
In this experimental example, filter paper enzyme classical in this area is adopted to carry out bacteriostatic test, wherein:
1. material:
1.1 for examination strain:
Actinomyces viscosus (A.viscosus ATCC 15987) and Streptococcus mutans (S.mutans ATCC 25175) step on bio tech ltd purchased from Shanghai three.
1.2 culture fluid:
Nutrient agar and nutrient broth, step on bio tech ltd purchased from Shanghai three.
1.3 test methods:
Actinomyces viscosus (A.viscosus ATCC 15987) and Streptococcus mutans (S.mutans ATCC 25175) are inoculated in agar plate nutritional solution plane, evenly gather during inoculation.The aseptic circular filter paper sheet of tweezer immerses the Chinese herbal medicine extract in embodiment 1, fully after dipping, is attached in the agar plate nutritional solution plane of inoculated bacteria.Agar plate is placed in the incubator of 37 DEG C, incubation 24 hours.Measure the diameter of bacterial restrain.Measure and average for 3 times.
1.4 results:
The average diameter of the bacterial restrain of actinomyces viscosus (A.viscosus ATCC 15987) is 30.34 mm, the average diameter of the bacterial restrain of Streptococcus mutans (S.mutans ATCC 25175) is 26.47mm, shows that Chinese herbal medicine extract of the present invention has obvious fungistatic effect.
experimental example 2: clinical trial.
1. clinical data:
With reference to " cariology " (Yue Songling edits. the 1st edition, Chengdu: the Sichuan People's Press, 1983: 224-225,280-281) the diagnostic criteria of dental caries choose the shallow middle dental caries children of 40 example as the object of observation.
Be divided into test group and matched group at random, wherein: test group 20 example, the range of age be 4-8 year, average 5.4 years old, wherein men and women each 10 example; Matched group 20 example, the range of age be 4-8 year, average 5.2 years old, wherein men and women each 10 example; All without taking any antibiotic medicine before medical.
2. observational technique:
Test group uses the toothpaste of embodiment 1 and the obtained Chinese herbal medicine extract of embodiment 2 and embodiment 4 and embodiment 5 respectively, every day 3 times, wherein: the using method of Chinese herbal medicine extract is directly used in after the meal to gargle, and each 20ml, is contained in mouth and gargles 30 seconds; The using method of toothpaste is after the meal for brushing teeth, each 1g; It within 3 months, is 1 course for the treatment of; Matched group does not use Chinese herbal medicine extract of the present invention and toothpaste; Test group is all identical with daily life custom with the diet of matched group every day.
3. efficacy assessment standard:
Adopt plaque index change as the standard of efficacy assessment standard.Plaque index being reduced more than 1 is assessed as effectively, plaque index is remained unchanged or increase by more than 1 be assessed as invalid.Plaque index (plaque index, PLI) is proposed in 1964 by Silness and Loe, scores and do not score according to bacterial plaque area coverage according to the thickness of pressure surface bacterial plaque.For evaluating dental health and weighing periodontal disease prevention effect.
With the method inspection of the bonding probes of inspection, inspection to row dry facing with probe, scores according to the amount of bacterial plaque and thickness.Plaque index section checks dental pattern face, also can check several selected teeth.Every tooth all checks 4 facings, i.e. nearly middle buccal surface, center buccal surface, middle buccal surface far away and lingual surface.Scoring of every tooth is that 4 facings score sum divided by 4, and individual scores as every tooth a few minutes sum is divided by being subject to inspection tooth number.
0=Yin Yuan district is without bacterial plaque;
The facing in 1=Yin Yuan district has thin bacterial plaque, but inspection is invisible, if can hang up bacterial plaque with the side of probe pinpoint;
2=is in gum edge or the visible moderate bacterial plaque of proximal surface;
3=gingival sulcus Nei Huoyinyuan district and proximal surface have a large amount of soft enough.
According to the plaque index before said method determination test and after the course for the treatment of, and change the result of the test obtained below according to plaque index.
4. result of the test:
For test group, the plaque index having the plaque index of 16 routine patients to reduce by 2,4 routine patients reduces 1.Effective percentage 100%.For matched group, the plaque index of 18 routine patients increases the plaque index increase by 2 of 1,2 routine patients.
5. untoward reaction:
Do not find obvious untoward reaction over the course for the treatment of.
Thus, Chinese herbal medicine extract of the present invention significantly can suppress the generation of oral cavity anaerobium, it has significant curative effect for preventing and treating children caries, and be free from side effects, safety is high, clinic promote, and Chinese herbal medicine extract of the present invention have raw material be easy to obtain, simple, the lower-cost advantage of preparation method, can be used for preparing medicament, food or the article of everyday use of preventing and treating children caries, thus there is wide market prospect and using value.
Finally should be noted that; above embodiment is only for illustration of technical scheme of the present invention but not limiting the scope of the invention; although be explained in detail the present invention with reference to preferred embodiment; those of ordinary skill in the art is to be understood that; can modify to technical scheme of the present invention or equivalent replacement, and not depart from essence and the scope of technical solution of the present invention.
Claims (10)
1. prevent and treat a Chinese herbal medicine extract for children caries, it is characterized in that: be made up of the raw material of following weight portion:
Herba Scutellariae Barbatae 12 ~ 20 parts;
Folium Callicarpae Formosanae 30 ~ 40 parts;
Ganoderma 12 ~ 18 parts;
Flos Osmanthi Fragrantis 10 ~ 15 parts;
Fructus Piperis Longi 5 ~ 15 parts;
Radix seu Folium Alchorneae trewioidis 8 ~ 15 parts;
Flos Chrysanthemi Indici 8 ~ 15 parts;
Folium Baeckeae 6 ~ 12 parts;
Radix Et Caulis Acanthopanacis Senticosi 6 ~ 12 parts.
2. a kind of Chinese herbal medicine extract preventing and treating children caries according to claim 1, is characterized in that: be made up of the raw material of following weight portion:
Herba Scutellariae Barbatae 15 parts;
Folium Callicarpae Formosanae 35 parts;
Ganoderma 13 parts;
Flos Osmanthi Fragrantis 12 parts;
Fructus Piperis Longi 8 parts;
Radix seu Folium Alchorneae trewioidis 10 parts;
Flos Chrysanthemi Indici 10 parts;
Folium Baeckeae 9 parts;
Radix Et Caulis Acanthopanacis Senticosi 10 parts.
3. a kind of Chinese herbal medicine extract preventing and treating children caries according to claim 1, is characterized in that: be made up of the raw material of following weight portion:
Herba Scutellariae Barbatae 18 parts;
Folium Callicarpae Formosanae 32 parts;
Ganoderma 15 parts;
Flos Osmanthi Fragrantis 15 parts;
Fructus Piperis Longi 10 parts;
Radix seu Folium Alchorneae trewioidis 10 parts;
Flos Chrysanthemi Indici 12 parts;
Folium Baeckeae 7 parts;
Radix Et Caulis Acanthopanacis Senticosi 8 parts.
4. a kind of preparation method of preventing and treating the Chinese herbal medicine extract of children caries according to claims 1 to 3 any one, is characterized in that: comprise the following steps:
(1) pretreatment:
Get the raw material of formula ratio, after cleaning, through 40 ~ 60 DEG C of drying 10 ~ 16 h;
(2) grind:
Ground by raw material after drying, sieve after pulverizing through 45 ~ 200 orders, obtain powder mixture, cold preservation is for subsequent use;
(3) ultrasonic extraction:
The powder mixture that step (2) obtains is put into the extraction pot of sealing, then the pure water of 7 ~ 10 times amount of powder mixture weight is added, soak 3 ~ 5h, ultrasonic extraction is carried out under 40 ~ 50 DEG C of conditions, supersonic frequency is 30 ~ 60kHZ, and at interval of 5min ultrasonication once, each ultrasonication time is 3min, total extraction time is 25 ~ 40min, obtains extracting solution;
(4) filter:
Extracting solution cooling step (3) obtained, collecting by filtration filtrate, after filtrate sterilizing, obtain the Chinese herbal medicine extract of described control children caries.
5. prevent and treat a toothpaste for children caries, it is characterized in that: be made up of the raw material of following weight portion:
Chinese herbal medicine extract 5 ~ 10 parts;
Sorbitol 110 ~ 135 parts;
Silicon dioxide 30 ~ 40 parts;
0.3 ~ 1 part, glucide;
0.1 ~ 0.3 part, essence;
Xanthan gum 0.5 ~ 2.5 part;
PEG400 3 ~ 8 parts;
Antiseptic 0.01 ~ 0.05 part;
Herba Menthae 0.5 ~ 2 part;
Sodium lauryl sulphate 1 ~ 4 part;
Described Chinese herbal medicine extract is the Chinese herbal medicine extract adopting the method for claim 4 to prepare;
The preparation method of described toothpaste is as follows:
By formula ratio, Chinese herbal medicine extract, sorbitol, silicon dioxide, glucide, essence, Herba Menthae are added in hermetically sealed can, be heated to 40 ~ 50 DEG C, stir while add the xanthan gum of formula ratio, Polyethylene Glycol, sodium lauryl sulphate and antiseptic, mixture is obtained after stirring, then mixture is cooled to room temperature, inspect by random samples qualified after carry out fill, namely obtain described toothpaste.
6. a kind of toothpaste preventing and treating children caries according to claim 5, is characterized in that: be made up of the raw material of following weight portion:
Chinese herbal medicine extract 8 parts;
Sorbitol 120 parts;
Silicon dioxide 36 parts;
0.5 part, glucide;
0.1 part, essence;
Xanthan gum 1 part;
PEG400 5 parts;
Antiseptic 0.02 part;
Herba Menthae 1 part;
Sodium lauryl sulphate 1 part.
7. Chinese herbal medicine extract is preparing the application in the medicament of control children caries, food or article of everyday use, it is characterized in that: described Chinese herbal medicine extract is the Chinese herbal medicine extract of the control children caries described in claims 1 to 3 any one.
8. application according to claim 7, is characterized in that: the dosage form of described medicament is tablet, unguentum or spray.
9. application according to claim 7, is characterized in that: the classification of described food is chewing gum, buccal tablet or chewing gum sugar.
10. application according to claim 7, is characterized in that: the classification of described article of everyday use is toothpaste, dentifrice, mouthwash or oral spray.
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| CN106265087A (en) * | 2016-09-22 | 2017-01-04 | 武汉伢典生物科技有限公司 | A kind of root canal flushing liquor and preparation method thereof |
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|---|---|---|---|---|
| CN1331968A (en) * | 2001-07-18 | 2002-01-23 | 广州美晨股份有限公司 | Chinese medicine toothpaste |
| CN101862399A (en) * | 2010-06-28 | 2010-10-20 | 赵丽侠 | Medicine for preventing and treating pediatric saprodontia and preparation method thereof |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106265087A (en) * | 2016-09-22 | 2017-01-04 | 武汉伢典生物科技有限公司 | A kind of root canal flushing liquor and preparation method thereof |
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Application publication date: 20150930 |