CN107050106A - A kind of lozenge for being used to prevent and treat chronic pharyngitis - Google Patents

A kind of lozenge for being used to prevent and treat chronic pharyngitis Download PDF

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Publication number
CN107050106A
CN107050106A CN201710494005.8A CN201710494005A CN107050106A CN 107050106 A CN107050106 A CN 107050106A CN 201710494005 A CN201710494005 A CN 201710494005A CN 107050106 A CN107050106 A CN 107050106A
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parts
lozenge
chronic pharyngitis
prevent
milk
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CN201710494005.8A
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刘国灿
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56Materials from animals other than mammals
    • A61K35/63Arthropods
    • A61K35/64Insects, e.g. bees, wasps or fleas
    • A61K35/644Beeswax; Propolis; Royal jelly; Honey
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/20Milk; Whey; Colostrum
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/34Campanulaceae (Bellflower family)
    • A61K36/346Platycodon
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/53Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/534Mentha (mint)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2013Organic compounds, e.g. phospholipids, fats
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2013Organic compounds, e.g. phospholipids, fats
    • A61K9/2018Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates

Abstract

A kind of lozenge for being used to prevent and treat chronic pharyngitis, it is prepared from by the raw material of following parts by weight:44 50 parts of royal jelly, 17 23 parts of honey, 56 parts of propolis, 20 30 parts of balloonflower root, 10 16 parts of peppermint, 10 16 parts of milk, 4.5 5.5 parts of pharmaceutic adjuvant.The lozenge for being used to prevent and treat chronic pharyngitis prepared using inventive formulation, cool taste, lozenge surface is smooth, uniform color, be difficult sliver, and to human body taste fanout free region, with anti-inflammation and sterilization is antiviral, the clear phlegm of relieving sore-throat, enhancing body immunity the effect of.

Description

A kind of lozenge for being used to prevent and treat chronic pharyngitis
Technical field
The invention belongs to technical field of traditional Chinese medicines, and in particular to a kind of lozenge for being used to prevent and treat chronic pharyngitis.
Technical background
Chronic pharyngitis is a kind of common disease, and it is because of acpuei pharyngitis recurrent exerbation mostly or treats not thorough, and neighbouring device Official's focus stimulates such as nasosinusitis, tonsillitis, nasopharyngitis, tracheitis to cause.Chronic pharyngitis constitutional symptom is not obvious, and with Based on local symptom, various chronic pharyngitis symptom is substantially similar, such as throat discomfort sense, foreign body sensation, burning heat sensation, dry sensation or stimulation Sense, this, can be with nausea when brush teeth in the morning mainly caused by the lymph follicle of its secretion and hypertrophy is stimulated.Though chronic pharyngitis So less weigh, but the course of disease is longer, be difficult recovery from illness, current western medical treatment is, by antibiotic symptom management, but to take mostly Too many antibiotic is likely to result in the imbalance of bottleneck throat normal flora, causes resistance to strengthen, immune function of human body decline, causes Make Relapse rate refractory, and use cold and cool property composition treatment more Chinese traditional treatment, long-term taking is bad to taste.
The content of the invention
The purpose of the present invention is that provides a kind of for preventing and treating chronic pharynx to solve the deficiencies in the prior art Scorching lozenge.
The purpose of the present invention is realized with following technical proposals:
A kind of lozenge for being used to prevent and treat chronic pharyngitis, it is prepared from by the raw material of following parts by weight:Royal jelly 44- 50 parts, 17-23 parts of honey, 5-6 parts of propolis, 20-30 parts of balloonflower root, 10-16 parts of peppermint, 10-16 parts of milk, pharmaceutic adjuvant 4.5- 5.5 part.
A kind of above-mentioned lozenge for being used to prevent and treat chronic pharyngitis, wherein, prepared by the raw material of following parts by weight and Into:47 parts of royal jelly, 20 parts of honey, 5.5 parts of propolis, 25 parts of balloonflower root, 13 parts of peppermint, 13 parts of milk, 5.0 parts of pharmaceutic adjuvant.
A kind of above-mentioned lozenge for being used to prevent and treat chronic pharyngitis, wherein, the pharmaceutic adjuvant is xylitol and hard Fatty acid magnesium.
A kind of above-mentioned lozenge for being used to prevent and treat chronic pharyngitis, wherein, the parts by weight of the pharmaceutic adjuvant are wood 3.5-4.5 parts of sugar alcohol, 0.5-1.5 parts of magnesium stearate.
A kind of above-mentioned lozenge for being used to prevent and treat chronic pharyngitis, wherein, the parts by weight of the pharmaceutic adjuvant are wood 4 parts of sugar alcohol, 1 part of magnesium stearate.
The above-mentioned preparation method for being used to prevent and treat the lozenge of chronic pharyngitis, comprises the following steps:
(1)Get the raw materials ready
1. the preparation of propolis liquid;2. the preparation of balloonflower root peppermint immersion liquid;3. the fermentation of milk:Milk is cooled to after pasteurization Inoculating bifidobacterium and lactic acid bacteria at 44-48 DEG C, in 40-44 DEG C of fermentation, pH value stops when reaching 4-5, is deposited 4 hours at 0-4 DEG C Afterwards, take out stand-by;
(2)Prepare
Weigh royal jelly, honey, xylitol and the step of above-mentioned parts by weight(1)The propolis liquid of middle acquisition, the immersion liquid of balloonflower root peppermint, hair Milk mixing after ferment, is then sieved, and obtained wet granular is dried under the conditions of 40-50 DEG C, and it is less than 6% to be allowed to water content;
(3)Tabletting
By magnesium stearate and step(2)The particle of middle preparation is sufficiently mixed, and is carried out tabletting, is produced.
In inventive formulation, royal jelly is a kind of super nutritive product of high active ingredient, and its nutritional ingredient is easy to absorb, honeybee The royal jelly acid contained in royal jelly(10- hydroxyls-certain herbaceous plants with big flowers olefin(e) acid)There is stronger anti-inflammation, also contain immunoglobulin, energy Body immunity is significantly improved, flu and other diseases odds is reduced;Honey is sweet, mild-natured, returns spleen, lung, the heart, stomach, Large intestine channel, with nourishing Yin and moistening dryness, qi-restoratives moistening lung is detoxified, the effect of coordinating the drug actions of a prescription is usually used in xeropulmonary cough, physically weak, and intestinal dryness is just Secret, aphtha, scald, gastral cavity pain can also solve and contain fructose, glucose, enzyme, albumen in the poison of the rhizome of Chinese monkshood, monkshood, honey Matter, vitamin and several mineral materials, anaemia can be prevented and treated by often eating, heart disease, enterogastritis etc., and can improve body immunity;Honeybee Glue can sterilize, sterilize, sterilizing, antibacterial, mould proof, anti-corrosion, solve the defect that antibiotic only works to single microorganism, and do not have There is side effect, in addition, propolis or natural antiviral substance have stronger suppression to a variety of viruses and killed and make With, meanwhile, propolis can also strengthen immunity, the disease-resistant ability of enhancing human body;Balloonflower root facilitaing lung, relieving sore-throat, eliminating the phlegm, apocenosis, for coughing Cough abundant expectoration, uncomfortable in chest not smooth, pharyngalgia, sound is mute, lung carbuncle pyemesis, sore purulence is not into bursting;Peppermint is pungent, cool in nature, enters lung, Liver Channel, evacuation Wind-heat, head clearing, relieving sore-throat promoting eruption, soothing the liver promoting the circulation of qi cures mainly affection of exogenous wind-heat, headache, abscess of throat, food stagnation inflatable, aphtha, tooth Bitterly, stagnation of QI due to depression of the liver, it is uncomfortable in chest;Milk is sweet, mild-natured, be slightly cold, and entering the heart, lung, stomach has a qi-restoratives damage, beneficial lung stomach, promote the production of body fluid ease constipation it Effect, for weakness due to chronic disease, insufficiency of vital energy and blood, malnutrition, dysphagia and regurgitation, gastric and duodenal ulcer, quench one's thirst, constipation;Lactic acid Bacterium is a kind of beneficial bacterium, can not only improve the nutritive value of milk, the keeping quality and added value of lozenge, but also can adjust Colony balance in stomach;Bifidobacterium is also beneficial bacterium, and lactic acid bacteria and Bifidobacterium can suppress the growth of human body harmful bacteria, The infection of pathogen is resisted, the vitamin that synthesized human needs promotes absorption of the human body to mineral matter, produces acetic acid, propionic acid, fourth The organic acid such as acid and lactic acid stimulates intestines peristalsis, promotes defecation, prevents constipation and suppresses enteron aisle putrefaction, purification enteron aisle ring Border, decomposition carcinogen, stimulation human immune system, so as to improve important role in terms of resistance against diseases.Xylitol is A kind of sweetener;Magnesium stearate is a kind of releasing agent, and lubricant, antiplastering aid can increase the mobility of particle in tabletting, preventing and treating Sticking, while can also make to suppress, the lozenge surface come is smooth, and uniform color is difficult sliver.
Chronic pharyngitis is mucosa and submucous tissue and the chronic inflammation of lymphoid tissue, shows as throat foreign matter more Sense, and chronic inflammation is difficult to cure how relevant with the hypoimmunity of patient, in above-mentioned raw materials, royal jelly, honey, propolis Anti-inflammation and sterilization is antiviral;Balloonflower root, the clear phlegm of peppermint relieving sore-throat, and balloonflower root energy priming is up guides drugs to illness station, peppermint being capable of seasoning;Honey heat Can be high, milk nutrition is high, and heat energy is low, and both arrange in pairs or groups, and can realize the effect that energy and nutrition giving young employees remedial-courses in general knowledge and vocational skills are filled;Royal jelly, honey, propolis Body immunity can be improved with the milk after fermentation, strengthens the resistance against diseases of human body, the generation and recurrence of pharyngitis is reduced;Except this Outside, honey, royal jelly, propolis can neutralize the cold and cool property of balloonflower root, peppermint and milk, reduce the stimulation to taste;Xylose Alcohol is a kind of sweetener;Magnesium stearate is a kind of releasing agent, and lubricant, antiplastering aid can increase the mobility of particle in tabletting, Sticking is prevented and treated, the lozenge surface come is smooth while can also make to suppress, and uniform color is difficult sliver.
Embodiment
Embodiment 1
A kind of lozenge for being used to prevent and treat chronic pharyngitis, it is prepared from by the raw material of following parts by weight:Royal jelly 44- 50 parts, 17-23 parts of honey, 5-6 parts of propolis, 20-30 parts of balloonflower root, 10-16 parts of peppermint, 10-16 parts of milk, pharmaceutic adjuvant 4.5- 5.5 parts, pharmaceutic adjuvant selects xylitol and magnesium stearate, and its consumption is 3.5-4.5 parts of xylitol, 0.5-1.5 parts of magnesium stearate.
The above-mentioned preparation method for being used to prevent and treat the lozenge of chronic pharyngitis, comprises the following steps:
(1)Get the raw materials ready
1. the preparation of propolis liquid:The propolis of above-mentioned parts by weight is weighed, the ethanol water (ethanol of 20-25 times of raw material weight is added Volume fraction is 70%), to be filtered after immersion 10-12h, and heating filtrate removes second alcohol and water, produces propolis liquid;
2. the preparation of balloonflower root peppermint immersion liquid:Balloonflower root, the peppermint of above-mentioned parts by weight are weighed, the water logging of 10-15 times of raw material weight is added Steep after 20-30min, big fire is decocted, after water boiling 10-20min, be cooked by slow fire 20-30min, filter out decoction, produce the leaching of balloonflower root peppermint Liquid;
3. the fermentation of milk:Inoculating bifidobacterium and lactic acid bacteria when milk is cooled to 44-48 DEG C after pasteurization, in 40-44 DEG C fermentation, pH value reach 4-5 when stop, 0-4 DEG C storage 4 hours after, take out it is stand-by;
(2)Prepare
Weigh royal jelly, honey, xylitol and the step of above-mentioned parts by weight(1)The propolis liquid of middle acquisition, the immersion liquid of balloonflower root peppermint, hair Milk mixing after ferment, then crosses 10-20 mesh sieves, obtained wet granular is dried under the conditions of 40-50 DEG C, being allowed to water content is Less than 6%;
(3)Tabletting
By the magnesium stearate and step of above-mentioned parts by weight(2)The particle of middle preparation is sufficiently mixed, and carries out tabletting, 0.5 ± 0.02g/ Piece, is produced.
The lozenge for being used to prevent and treat chronic pharyngitis prepared using said ratio and method, cool taste, lozenge Surface is smooth, uniform color, is difficult sliver, and to human body taste fanout free region, with anti-inflammation and sterilization is antiviral, the clear phlegm of relieving sore-throat, increasing The effect of strong body immunity.
Embodiment 2
A kind of lozenge for being used to prevent and treat chronic pharyngitis, it is prepared from by the raw material of following parts by weight:Royal jelly 47 Part, 20 parts of honey, 5.5 parts of propolis, 25 parts of balloonflower root, 13 parts of peppermint, 13 parts of milk, 5.0 parts of pharmaceutic adjuvant, pharmaceutic adjuvant is from wood Sugar alcohol and magnesium stearate, its consumption are 4 parts of xylitol, 1 part of magnesium stearate.
The above-mentioned preparation method for being used to prevent and treat the lozenge of chronic pharyngitis, comprises the following steps:
(1)Get the raw materials ready
1. the preparation of propolis liquid:The propolis of above-mentioned parts by weight is weighed, the ethanol water of 22.5 times of raw material weights is added(Ethanol body Fraction 70%), soak and filtered after 11h, heating filtrate removes second alcohol and water, produces propolis liquid;
2. the preparation of balloonflower root peppermint immersion liquid:Balloonflower root, the peppermint of above-mentioned parts by weight are weighed, the water immersion of 12.5 times of raw material weights is added After 25min, big fire is decocted, and after water boiling 15min, is cooked by slow fire 25min, is filtered out decoction, produce balloonflower root peppermint immersion liquid;
3. the fermentation of milk:Inoculating bifidobacterium and lactic acid bacteria when milk is cooled to 46 DEG C after pasteurization, ferment at 42 DEG C, Stop when pH value is up to 4.5, deposited 4 hours at 2 DEG C, taken out stand-by;
(2)Prepare
Weigh royal jelly, honey, xylitol and the step of above-mentioned parts by weight(1)The propolis liquid of middle acquisition, the immersion liquid of balloonflower root peppermint, hair Milk mixing after ferment, then crosses 10-20 mesh sieves, and obtained wet granular is dried under the conditions of 45 DEG C, and it is 2% to be allowed to water content;
(3)Tabletting
By the magnesium stearate and step of above-mentioned parts by weight(2)The particle of middle preparation is sufficiently mixed, and carries out tabletting, 0.5 ± 0.02g/ Piece, is produced.
The lozenge for being used to prevent and treat chronic pharyngitis prepared using said ratio and method, cool taste, lozenge Surface is smooth, uniform color, is difficult sliver, and to human body taste fanout free region, with anti-inflammation and sterilization is antiviral, the clear phlegm of relieving sore-throat, increasing The effect of strong body immunity.
Comparative example 1
A kind of lozenge for being used to prevent and treat chronic pharyngitis, it is prepared from by the raw material of following parts by weight:Royal jelly 47 Part, 20 parts of honey, 5.5 parts of propolis, 25 parts of balloonflower root, 13 parts of peppermint, 13 parts of milk.Specific preparation method be the same as Example 2.With implementation Example 2 is compared, and is not added with pharmaceutic adjuvant, and the prevention and treatment chronic pharyngitis lozenge prepared is rough, and color and luster is poor, and preferably Sliver, mouthfeel is not good enough yet.
Comparative example 2
A kind of lozenge for being used to prevent and treat chronic pharyngitis, it is prepared from by the raw material of following parts by weight:Royal jelly 47 Part, 20 parts of honey, 5.5 parts of propolis, 13 parts of milk, 5.0 parts of pharmaceutic adjuvant, pharmaceutic adjuvant select xylitol and magnesium stearate, its Consumption is 4 parts of xylitol, 1 part of magnesium stearate.Specific preparation method be the same as Example 2.Compared with Example 2, be not added with balloonflower root and Peppermint, the prevention and treatment chronic pharyngitis lozenge mouthfeel prepared is poor, and the patients with chronic pharyngitis effect for abundant expectoration is poor.
The formula for the prevention and treatment chronic pharyngitis lozenge that 3-19 of the embodiment of the present invention is provided is shown in Table 1-2.
Table 1
Table 2
Clinical trial
(1)Clinical data
100 patients for suffering from pharyngo-laryngitis chronica are recruited in certain hospital, are divided into experimental group, control group, every group of 50 people, wherein testing Group takes the Traditional Chinese medicine lozenge of the present invention, and control group takes the chronic throat piece of certain brand.
(2)Treatment method
The patient of experimental group takes the Traditional Chinese medicine lozenge of the present invention daily, takes in the morning and evening, one at a time;
The patient of control group takes the chronic throat piece of certain brand daily, is taken by operation instruction.
(3)Diagnostic criteria
Cure:Chronic inflammation symptom is wholly absent;
Take a turn for the better:Chronic pharyngitis symptom is clearly better;
It is invalid:Symptom is without change before and after medication.
(4)Treatment results
50 patients of experimental group are taken after Traditional Chinese medicine lozenge first quarter moon of the present invention, cure 44, cure rate 88% takes a turn for the better 6, takes a turn for the better Rate 12%, invalid 0, inefficiency 0%, after being discontinued one month, no recurrence;
50 patients of control group are taken after the chronic throat piece first quarter moon of certain brand, cure 35, cure rate 70% takes a turn for the better 14, Improvement rate 28%, invalid 1, inefficiency 2%, after being discontinued one month, recurrence rate is up to 22%.

Claims (6)

1. a kind of lozenge for being used to prevent and treat chronic pharyngitis, it is characterised in that be prepared from by the raw material of following parts by weight: It is 44-50 parts of royal jelly, 17-23 parts of honey, 5-6 parts of propolis, 20-30 parts of balloonflower root, 10-16 parts of peppermint, 10-16 parts of milk, medicinal 4.5-5.5 parts of auxiliary material.
2. a kind of lozenge for being used to prevent and treat chronic pharyngitis as claimed in claim 1, it is characterised in that by following weight The raw material of part is prepared from:47 parts of royal jelly, 20 parts of honey, 5.5 parts of propolis, 25 parts of balloonflower root, 13 parts of peppermint, 13 parts of milk, medicine With 5.0 parts of auxiliary material.
3. a kind of lozenge for being used to prevent and treat chronic pharyngitis as described in claim any one of 1-2, it is characterised in that institute Pharmaceutic adjuvant is stated for xylitol and magnesium stearate.
4. a kind of lozenge for being used to prevent and treat chronic pharyngitis as claimed in claim 3, it is characterised in that described medicinal auxiliary The parts by weight of material are 3.5-4.5 parts of xylitol, 0.5-1.5 parts of magnesium stearate.
5. a kind of lozenge for being used to prevent and treat chronic pharyngitis as claimed in claim 4, it is characterised in that described medicinal auxiliary The parts by weight of material are 4 parts of xylitol, 1 part of magnesium stearate.
6. being used for as described in claim any one of 3-5 prevents and treats the preparation method of the lozenge of chronic pharyngitis, its feature It is, comprises the following steps:
(1)Get the raw materials ready
1. the preparation of propolis liquid;2. the preparation of balloonflower root peppermint immersion liquid;3. the fermentation of milk:Milk is cooled to after pasteurization Inoculating bifidobacterium and lactic acid bacteria at 44-48 DEG C, in 40-44 DEG C of fermentation, pH value stops when reaching 4-5, is deposited 4 hours at 0-4 DEG C Afterwards, take out stand-by;
(2)Prepare
Weigh royal jelly, honey, xylitol and the step of above-mentioned parts by weight(1)The propolis liquid of middle acquisition, the immersion liquid of balloonflower root peppermint, hair Milk mixing after ferment, is then sieved, and obtained wet granular is dried under the conditions of 40-50 DEG C, and it is less than 6% to be allowed to water content;
(3)Tabletting
By magnesium stearate and step(2)The particle of middle preparation is sufficiently mixed, and is carried out tabletting, is produced.
CN201710494005.8A 2017-06-26 2017-06-26 A kind of lozenge for being used to prevent and treat chronic pharyngitis Pending CN107050106A (en)

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Publication number Priority date Publication date Assignee Title
CN110547420A (en) * 2018-05-30 2019-12-10 福州大学 Royal jelly enzyme buccal tablet and preparation method thereof
CN110772544A (en) * 2019-11-13 2020-02-11 嘉善鸿域科技咨询有限公司 Propolis product and its application in apparatus and wound treatment

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CN103977166A (en) * 2014-06-03 2014-08-13 湖北卫尔康现代中药有限公司 Sore throat-relieving throat lozenge and preparation method thereof

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110547420A (en) * 2018-05-30 2019-12-10 福州大学 Royal jelly enzyme buccal tablet and preparation method thereof
CN110772544A (en) * 2019-11-13 2020-02-11 嘉善鸿域科技咨询有限公司 Propolis product and its application in apparatus and wound treatment

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