CN102940595A - Mouthwash with functions of antibiosis, antiphlogosis and deodorization, and preparation method and use thereof - Google Patents
Mouthwash with functions of antibiosis, antiphlogosis and deodorization, and preparation method and use thereof Download PDFInfo
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Abstract
The invention discloses a mouthwash with functions of antibiosis, antiphlogosis and deodorization, and a preparation method of and the use of the mouthwash. The mouthwash comprises main raw materials, i.e. pericarpium granati extractive, flos rosae rugosae and calyx seu fructus physalis, and moisture preserving agent, sweetening agent, preservative and distilled water. The mouthwash can be used due to the combined action of various active ingredients, can form into the stoppage on the surfaces of teeth, can enable the bacterium to be hard to be attached onto the surfaces of the teeth, and can reduce the bacterium which is attached onto the surfaces of the teeth and causes the bacterial plaque, so that the oral hygiene can be kept, and the bad breath can be eliminated, therefore, the mouthwash can be used for preventing or treating the gingivitis, the periodontitis, the dental ulcer, and the oral and throat inflammation; and the bad breath can be eliminated, and the freshens breath can be kept, so that the mouthwash not only can be used for the adjuvant therapy of the oral inflammation, but also can be used for the daily oral health, and is free from any side effects after being used for a long time. When the mouthwash is used, due to the mouth washing action, the mouthwash not only is good for the motion of the muscles around the oral cavity, but also can promote the self-cleaning function of the oral cavity, thereby being the optimal choice for keeping the oral hygiene, and preventing and treating the oral infection.
Description
Technical field
The present invention relates to a kind of collutory with anti-inflammation deodorize and its production and use, relate in particular to a kind of have anti-inflammation, deodorize, liquid oral rinse oral fluid easy to use, without any side effects and its production and use.
Background technology
The oral cavity is one of approach of pathogenic microorganism intrusion human body, the temperature in oral cavity, humidity and food debris, and suitable microbial reproduction growth, intraoral diastema, gums groove are difficult to cleaning, and these anatomical features are conducive to bacterial growth.So oral hygiene is very important to the health of human body, especially high heat, postoperative and disturbance of consciousness, artificial respiration's patient is because of can not oral feeding, salivation reduces, xerostomia, the oral cavity self-purification capacity descends, and causes bacterial reproduction power to strengthen, and, can not swallow because of oral secretion, remain in the oral cavity, become the good culture medium of antibacterial, these may become the reason of dental caries, periodontal abscess, also may cause bronchitis, pneumonia.In addition, because saliva etc. exists in this special interior environment of oral cavity, under Constant humidity, temperature and nutrition, the bacterial reproduction growth, all more parasitic microorganisms when normal are when our resistance descends, they are active causing a disease just, make the oral cavity bacterium amount reproduction, carbohydrate breakdown, fermentation, acid production strengthen, thereby not only cause easily periodontal disease, parotitis etc., and can make the oral cavity smelly, affect appetite and digestive function, cause oral cavity infection, even cause systemic infection.Show that according to the Chinese oral cavity health authority of association statistical data China's oral disease prevalence is up to 97.6%, almost everybody has oral disease in various degree, such as diseases such as toothache, gingivitis, periodontitis, gingival hemorrhages.
Oral health is the symbol of national society's civilization, and World Health Organization (WHO) has classified oral health as an important indicator estimating level of human health.Along with the development of science and civilization, the raising of people quality of life, everybody strengthens gradually to the consciousness of oral cavity health, and it is particularly important that mouth care seems.Although the importance of mouth care has obtained approval at home, the degree of knowledge and value is still inadequate.Mouth care is the prevention disease in mouth, keeps, promotes science and technology healthy, that improve rehabilitation patients ' life quality (QQL), is to keep oral cavity cleaning, one of prophylactic means.Mouth care can make the oral cavity bacterium number reduce, because mechanical stimulus promotes salivation, strengthens the self-cleaning power in oral cavity, thereby keep oral cavity cleaning, moistening, make the patient comfortable, salubrious, the complication such as prevention of oral infections, prevent halitosis, sordes, promote appetite, safeguard the normal function in oral cavity.Mouth care has not been simple oral cavity cleaning, and mouth care is from simple prevent disease, develops into maintenance, promotes healthyly, improves the science and technology of patients ' life quality.Being used at present the medicament of oral disease and mouth care such as buccal tablet, chewing gum, diaphragm etc. is difficult to penetrate at teeth space, can not bring into play due therapeutical effect, and the preparation that uses adopts crude extract to make mostly, and active constituent content is low and unstable, is difficult to the effect that reaches set.
Pericarpium Granati is the Uygur medicine medicinal herbs most in use, is the dry peel of Punicaceae plant Punica granatum L. (punicagranatum L.).Pericarpium Granati acid, puckery are mainly used in chronic diarrhea, the card such as hemorrhage in China's traditional medicine.Polyphenol in the Pericarpium Granati is the general name that a class has the polyphenol hydroxyl chemical compound, comprise the multiple compounds such as elladitannin, Galla Turcica (Galla Helepensis) tannin, ellagic acid, gallic acid, content is about the 10%-20% of its dry mass, has multiple physiology and the pharmacologically actives such as antibiotic, antioxidation, defying age, anti-cancer and cancer-preventing, blood pressure lowering and prevention cardiovascular and cerebrovascular disease.The present invention is on the basis of 200910113497.7 pomegranate peel polyphenol anti-inflammation effervescent tablets and its production and use, and the purposes of Pericarpium Granati extract is further studied.
Flos Rosae Rugosae is recorded in one one of Chinese Pharmacopoeia version in 2010 and Uygur's medical material standard first volume, is the Uygur medicine medicinal herbs most in use, has detumescence, hemostasis, pain relieving, heat clearing away heart tonifying, profit and just waits effect, have that heat clearing away is quenched one's thirst, vital energy regualting and blood circulation-promoting, should the gas skin care effect.Contain abundant polyphenols in the Flos Rosae Rugosae.Polyphenol is main antioxidant, has the SOD activity, can effectively remove free radical, remove pigmentation, and this is because the phenolic hydroxyl group of polyphenols has very strong reproducibility.So Flos Rosae Rugosae has the function of U.S. face.Flos Rosae Rugosae is termed meaning gentleman medicine in Chinese medicine and Chinese materia medica.The traditional Chinese medical science is thought, the sweet little hardship of Flos Rosae Rugosae floral leaf is warm in nature, nontoxic, enters liver spleen two warps." book on Chinese herbal medicine is new again " cloud: " the strongly fragrant gas of soothing liver-QI gallbladder, spleen invigorating pathogenic fire reducing "." book on Chinese herbal medicine justice " record: " fragrance is the denseest, and is turbid clearly and not, and and not violent, the easing the affected liver stomach of waking up, thin gas is invigorated blood circulation, logical the stopping up of a surname stagnates and the fraud of absolutely not hot temperature drying, breaks without it "." food book on Chinese herbal medicine " calls it, and " fragrance of food is sweet and refreshing for main sharp lung spleen, the liver benefiting gallbladder, makes us refreshing refreshing." therefore, Flos Rosae Rugosae China-directly be rare medicinal herbs, be widely used in tcm prescription and make up a prescription.Modern scientific research learns, Flos Rosae Rugosae is the food medicine excellent flowers of holding concurrently, and has good nutritive value and health care.
Calyx Seu Fructus Physalis is the dry Constellation calyx of plant of Solanaceae Calyx seu fructus physalis Physalis alkekengiL.var.franchetii (mast.) Makino or with the Constellation calyx of fruit.Its nature and flavor are sweet, sour, cold, have heat clearing away, detoxifcation, diuresis, clears phlegm, be used for the treatment of that pharyngalgia is silent, phlegm-heat cough, dysuria, external treatment pemphigus, eczema etc.Calyx Seu Fructus Physalis contains several large class chemical constituents such as lactone, flavonoid, terpenoid, alkaloids, sterols, amino acids and inorganic elements, such as physalin compounds, luteolin etc., has clear and definite antibiotic, antiinflammatory, antiallergic and analgesia isoreactivity.Be usually used in clinically acute, suppurative tonsillitis and laryngopharynx swelling and pain.
Majority is that Chinese medicine and western medicine is in conjunction with preventing and treat oral disease in the collutory on the existing market, and take Western medicine as main composition, though have preferably bacteriostasis, but the Western medicine side effect produces drug resistance greatly, easily, there is the not good and adverse effect of mouthfeel, severe patient even may cause that dysbacteriosis, oral mucosa strip off and superposition infects; Some mouth care solution that contain medicinal herb components have then just shown the superiority of oneself in this regard.The present invention utilizes medicinal and edible plant to make pure Chinese medicine gargle for primary raw material, by the combined effect of various active composition, through antibacterial activity in vitro, anti-inflammatory activity research, the result shows the activity of staphylococcus aureus and Hemolytic streptococcus stronger, can alleviate the inflammatory edema due to the dimethylbenzene.Be applicable to the oral diseases such as oral ulcer, periodontitis, gingivitis, gingival hemorrhage, halitosis, pharyngolaryngitis, tonsillitis.
Summary of the invention
The purpose of this invention is to provide a kind of collutory with anti-inflammation deodorize and its production and use, this collutory is formulated with Pericarpium Granati extract, Flos Rosae Rugosae, Calyx Seu Fructus Physalis, wetting agent, sweeting agent, antiseptic and distilled water, this collutory can cause obstruction at dental surface, make antibacterial be difficult to stick to dental surface, reduce the antibacterial that is attached to dental surface and causes dental plaque, keep oral cavity cleaning, remove halitosis, can be used for prevention or treat gingivitis, periodontitis, oral ulcer and oral cavity and laryngopharyngitis thereby play; Simultaneously can eliminate halitosis, keep breath freshening.The auxiliary treatment that both can be used for oral inflammation also can be used for daily oral cavity health, and life-time service can not produce any side effect, and this product utilizes the rinsing the mouth action when using, and not only is conducive to the oral cavity motion of muscle on every side, can also promote the self-cleaning action in oral cavity.The rinsing the mouth method is simple, convenient, is easy to be accepted and implement by the patient, is the optimum selection that keeps oral hygiene, control oral cavity infection.
A kind of collutory with anti-inflammation deodorize of the present invention, this collutory is to be that Pericarpium Granati extract 5-20%, Flos Rosae Rugosae 10-30%, Calyx Seu Fructus Physalis 10-30%, wetting agent are that glycerol, propylene glycol or sorbitol 5-20%, sweeting agent are that saccharin sodium, cyclamate or aspartame 0.5-2%, antiseptic are sodium benzoate or potassium sorbate 0.1-1% by percentage by weight, and surplus is that distilled water is made.
Described preparation method with collutory of anti-inflammation deodorize follows these steps to carry out:
A, get Flos Rosae Rugosae 10-30%, Calyx Seu Fructus Physalis 10-30% and add 5-20 doubly to measure concentration be that the 30%-90% alcohol heating reflux extracts 1-4 time, each 1-3 hour, filter the merging filtrate decompression recycling ethanol, be concentrated into the solution that relative density is the 1.05-1.10 temperature 60 C, for subsequent use;
B, getting Pericarpium Granati extract 5-20%, to be dissolved in wetting agent be among glycerol, propylene glycol or the sorbitol 5-20%, stir, join in the solution of step a, adding simultaneously sweeting agent is that saccharin sodium, cyclamate or aspartame 0.5-2%, antiseptic are sodium benzoate or potassium sorbate 0.1-1% and surplus distilled water, abundant stirring and evenly mixing, leave standstill filtration after 24 hours, packing, fill, can obtain having the rinse product of anti-inflammation deodorize.
The purposes of described collutory, this collutory are used for the medicine at preparation prevention or treatment gingivitis, periodontitis, oral ulcer and oral cavity and laryngopharyngitis.
The purposes of described collutory, this collutory is used for the auxiliary treatment of oral inflammation or is used for daily oral cavity health.
A kind of collutory with anti-inflammation deodorize of the present invention and its production and use, the preparation of wherein said Pericarpium Granati extract:
Get Pericarpium Granati and be ground into coarse powder, add the ethanol warm macerating, extract 3 times, each 1.5 hours, filter the merging filtrate decompression recycling ethanol, be concentrated into the concentrated solution that every mL is equivalent to crude drug 0.15～0.2g, be added on the macroporous adsorptive resins of having handled well, absorption 12h, during to the effluent paler colour, use again certain density ethanol elution with deionized water rinsing first, collect and contain alcohol eluen, Recycled ethanol, concentrating under reduced pressure and vacuum drying become dry extract, pulverize, cross 100 mesh sieves, for subsequent use.
A kind of collutory with anti-inflammation deodorize of the present invention and its production and use, it is as primary raw material take Pericarpium Granati extract, Flos Rosae Rugosae, Calyx Seu Fructus Physalis, formulated with wetting agent, sweeting agent, antiseptic and water, this product is by the combined effect of various active composition, can suppress, remove oral cavity bacterium, prevention or treatment gingivitis, periodontitis, oral ulcer and oral cavity and laryngopharyngitis, simultaneously, eliminate halitosis, keep breath freshening.This collutory is made by pure Chinese medicine, not only has whole effects of general collutory, and to human body without any side effect.The characteristics of this product are: raw material is easy to get, prepares simply, safety is good, can not damage the patient even swallow also.Prescription provided by the invention has good antibacterial action, can be used for collutory, tablet, granule, membrane, chewing gum, effervescent formulation etc., not only can be used for the auxiliary treatment of oral inflammation, also can be used for daily oral cavity health, be suitable for clinically large-scale promotion.
The specific embodiment
Embodiment 1(percentage by weight)
The preparation of Pericarpium Granati extract:
At first take by weighing Pericarpium Granati and be ground into coarse powder, adding 5-30, doubly to measure concentration be 50-70% ethanol warm macerating, temperature 30-70 ℃, extract 1-4 time, each 1-3 hour, filter, decompression filtrate recycling ethanol through macroporous resin chromatography, adsorbs 3-12h with medicinal liquid, it is closely colourless to be eluted to effluent with distilled water first, uses the 40-80% ethanol elution again, be collected into eluent colourless till, concentrated, after temperature 60 C is removed ethanol, the dry extract powder that gets of concentrating under reduced pressure, pulverize, cross the 60-140 mesh sieve, for subsequent use;
Gargle preparation:
A, get Flos Rosae Rugosae 10%, Calyx Seu Fructus Physalis 10%, adding 5 times of amount concentration is that 40% alcohol heating reflux extracts 2 times, each 1 hour, filter, and the merging filtrate decompression recycling ethanol is concentrated into the solution that relative density is 1.05-1.10 (temperature 60 C), and is for subsequent use;
B, get Pericarpium Granati extract 5% and be dissolved in the wetting agent propylene glycol 5%, stir, join in the solution after step a concentrates, add simultaneously sweeting agent saccharin sodium 0.5%, preservative sodium benzoate 0.1% and surplus distilled water, abundant stirring and evenly mixing, leave standstill filtration after 24 hours, packing, fill, can obtain having the rinse product of anti-inflammation deodorize.
Embodiment 2(percentage by weight)
The preparation of Pericarpium Granati extract is undertaken by embodiment 1;
Gargle preparation:
A, get Flos Rosae Rugosae 20%, Calyx Seu Fructus Physalis 20%, adding 10 times of amount concentration is that 60% alcohol heating reflux extracts 1 time, extracted 3 hours, and filtration, the merging filtrate decompression recycling ethanol is concentrated into the clear paste that relative density is 1.05-1.10 (temperature 60 C), and is for subsequent use;
B, get Pericarpium Granati extract 10% and be dissolved in the wetting agent propylene glycol 10%, stir, join in the solution after step a concentrates, add simultaneously sweeting agent cyclamate 0.8%, potassium sorbate preservative 0.5% and surplus distilled water, abundant stirring and evenly mixing, leave standstill filtration after 24 hours, packing, fill, can obtain having the rinse product of anti-inflammation deodorize.
Embodiment 3(percentage by weight)
The preparation of Pericarpium Granati extract is undertaken by embodiment 1;
Gargle preparation:
A, get Flos Rosae Rugosae 15%, Calyx Seu Fructus Physalis 20%, adding 15 times of amount concentration is that 30% alcohol heating reflux extracts 3 times, each 2 hours, filter, and the merging filtrate decompression recycling ethanol is concentrated into the solution that relative density is 1.05-1.10 (temperature 60 C), and is for subsequent use;
B, get Pericarpium Granati extract 15% and be dissolved in the wetting agent glycerol 10%, stir, add in the solution after step a concentrates, add simultaneously sweeting agent aspartame 0.6%, preservative sodium benzoate 0.3% and surplus distilled water, abundant stirring and evenly mixing, leave standstill filtration after 24 hours, packing, fill, can obtain having the rinse product of anti-inflammation deodorize.
Embodiment 4(percentage by weight)
The preparation of Pericarpium Granati extract is undertaken by embodiment 1;
Gargle preparation:
A, get Flos Rosae Rugosae 20%, Calyx Seu Fructus Physalis 30%, adding 20 times of amount concentration is that 70% alcohol heating reflux extracts 4 times, each 1 hour, filter, and the merging filtrate decompression recycling ethanol is concentrated into the solution that relative density is 1.05-1.10 (temperature 60 C), and is for subsequent use;
B, get Pericarpium Granati extract 20% and be dissolved in 15% glycerol, stir, join in the solution after step a concentrates, add simultaneously sweeting agent cyclamate 1%, potassium sorbate preservative 0.5% and surplus distilled water, abundant stirring and evenly mixing, leave standstill filtration after 24 hours, packing, fill, can obtain having the rinse product of anti-inflammation deodorize.
Embodiment 5(percentage by weight)
The preparation of Pericarpium Granati extract is undertaken by embodiment 1;
Gargle preparation:
A, get Flos Rosae Rugosae 30%, Calyx Seu Fructus Physalis 20%, adding 15 times of amount concentration is that 90% alcohol heating reflux extracts 2 times, each 2 hours, filter, and the merging filtrate decompression recycling ethanol is concentrated into the solution that relative density is 1.05-1.10 (temperature 60 C), and is for subsequent use;
B, get Pericarpium Granati extract 10% and be dissolved in the wetting agent sorbitol 5%, stir, join in the solution after step a concentrates, add simultaneously sweeting agent saccharin sodium 0.8%, preservative sodium benzoate 0.8% and surplus distilled water, abundant stirring and evenly mixing, leave standstill filtration after 24 hours, packing, fill, can obtain having the rinse product of anti-inflammation deodorize.
Embodiment 6(percentage by weight)
The preparation of Pericarpium Granati extract is undertaken by embodiment 1;
Gargle preparation:
A, get Flos Rosae Rugosae 15%, Calyx Seu Fructus Physalis 15%, adding 10 times of amount concentration is that 50% alcohol heating reflux extracts 3 times, each 2 hours, filter, and the merging filtrate decompression recycling ethanol is concentrated into the solution that relative density is 1.05-1.10 (temperature 60 C), and is for subsequent use;
Getting Pericarpium Granati extract 5% is dissolved in the wetting agent glycerol 5%, stir, join in the solution after step a concentrates, add simultaneously sweeting agent aspartame 0.5%, preservative sodium benzoate 0.2% and surplus distilled water, abundant stirring and evenly mixing, leave standstill filtration after 24 hours, packing, fill, can obtain having the rinse product of anti-inflammation deodorize.
Embodiment 7
A kind of purposes with collutory of anti-inflammation deodorize of the present invention:
The In Vitro Bacteriostasis experiment:
The preparation of the medicinal scraps of paper: select the strong and homogeneous filter paper of water absorbing force, break into the disk of 6mm with puncher, be sub-packed in clean dried in vitro, put into high-pressure sterilizing pot xeothermic (120 ℃ of temperature) sterilization after 2 hours, taking-up is put into thermostatic drying chamber and is carried out drying, get dried scraps of paper some, put into collutory, for subsequent use after infiltrating;
Extracorporeal bacteria inhibitor test-adopt paper disk method: staphylococcus aureus, escherichia coli, Candida albicans, Streptococcus mutans are inoculated in respectively Nutrient agar and blood agar inclined-plane, cultivated 18-24 hour, make bacteria suspension, Maxwell turbidimetry for Determination bacterial concentration makes it at 106-107cfu/ml.0.1ml bacterium liquid is coated respectively Nutrient agar and blood agar plate, each strain is done 3 Duplicate Samples, to contain the scraps of paper flicking of various medicinal liquids after half a minute on flat board, do negative control with the blank scraps of paper, antibacterial is taken out behind 37 ℃ of constant temperature culture 18h of temperature, by measuring the inhibition zone size, judge that tested strain to the medicinal liquid sensitivity, the results are shown in Table 1:
Table 1 bacteriostatic experiment result
The criterion of antibacterials sensitivity is: antibacterial circle diameter 〉=15mm is extremely sensitive, and 10-15mm is medium sensitivity, and＜10mm is drug resistance.
The mice ear experiment:
50 of KM mices, male and female half and half, body weight 18-22g, by the weight of animals, sex be divided at random NS matched group, positive control drug Dobell's solution (0.1ml/ only), basic, normal, high three the dosage groups of collutory (0.1ml/ only, 0.2ml/ only, 0.4ml/ only), every group 10, each administration group mice coating every day once, be applied to auris dextra, even be coated with 5 days, the blank group is coated with the distilled water of equivalent, behind the last coating 30min, each administration group is with distilled water flush away medicinal liquid, clean with cotton balls, only be coated with dimethylbenzene 0.1ml/ to mouse right ear, left ear is contrast.Behind the 30min, the disconnected neck of mice is put to death, with the card punch of diameter 8mm, the ears same area is respectively laid a slice, weigh respectively with electronic balance,, calculate and respectively organize the swelling degree as swelling with the difference of left and right auricle weight, obtain swelling rate, the results are shown in Table 2:
The impact of table 2 dimethylbenzene induced mice ear swelling experiment
Remarks: compare with matched group,
﹡P＜0.05,
﹡ ﹡P＜0.01, P〉0.05
As can be seen from Table 2, after the administration 5 days, dosage group in the collutory (0.2ml/ only), high dose group (0.4ml/ only) have the effect of obvious inhibition mice auricle swelling, the ear swelling value all is lower than the NS group, difference has significance (p＜0.05 or p＜0.01), show that collutory of the present invention has significant antiinflammatory action, the positive control Dobell's solution also has same purpose.
Claims (4)
1. collutory with anti-inflammation deodorize, it is characterized in that this collutory is is Pericarpium Granati extract 5-20%, Flos Rosae Rugosae 10-30%, Calyx Seu Fructus Physalis 10-30% by percentage by weight, wetting agent is glycerol, propylene glycol or sorbitol 5-20%, sweeting agent is saccharin sodium, cyclamate or aspartame 0.5-2%, antiseptic is sodium benzoate or potassium sorbate 0.1-1%, and surplus is that distilled water is formulated.
2. according to claims 1 described preparation method with collutory of anti-inflammation deodorize, it is characterized in that following these steps to carrying out:
A, get Flos Rosae Rugosae 10-30%, Calyx Seu Fructus Physalis 10-30% and add 5-20 doubly to measure concentration be that the 30%-90% alcohol heating reflux extracts 1-4 time, each 1-3 hour, filter the merging filtrate decompression recycling ethanol, be concentrated into the solution that relative density is the 1.05-1.10 temperature 60 C, for subsequent use;
B, getting Pericarpium Granati extract 5-20%, to be dissolved in wetting agent be among glycerol, propylene glycol or the sorbitol 5-20%, stir, join in the solution of step a, adding simultaneously sweeting agent is that saccharin sodium, cyclamate or aspartame 0.5-2%, antiseptic are sodium benzoate or potassium sorbate 0.1-1% and surplus distilled water, abundant stirring and evenly mixing, leave standstill filtration after 24 hours, packing, fill, can obtain having the rinse product of anti-inflammation deodorize.
3. the purposes of collutory according to claim 1 is characterized in that this collutory is used for the medicine at preparation prevention or treatment gingivitis, periodontitis, oral ulcer and oral cavity and laryngopharyngitis.
4. the purposes of collutory according to claim 1 is characterized in that this collutory, is used for the auxiliary treatment of oral inflammation or is used for daily oral cavity health.
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| CN2012105133458A CN102940595A (en) | 2012-12-04 | 2012-12-04 | Mouthwash with functions of antibiosis, antiphlogosis and deodorization, and preparation method and use thereof |
| CN201310648219.8A CN103860423B (en) | 2012-12-04 | 2013-12-03 | A kind of have collutory of anti-inflammation deodorize and its production and use |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103860423A (en) * | 2012-12-04 | 2014-06-18 | 中国科学院新疆理化技术研究所 | Collutory with bacterial-resisting, inflammation-eliminating and deodorizing functions and preparation method and use of collutory |
| CN106177923A (en) * | 2016-07-12 | 2016-12-07 | 方雅悯 | A kind of oral ulcer membrane and preparation method thereof |
| CN106237337A (en) * | 2016-08-05 | 2016-12-21 | 河南中帅医药科技股份有限公司 | A kind of liquid pharmaceutical formulation anticorrosive composite |
| CN107693430A (en) * | 2017-11-08 | 2018-02-16 | 江西草珊瑚消毒用品有限公司 | Draft nurses one's health antibacterial gargle |
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| CN107595696B (en) * | 2017-09-26 | 2020-12-15 | 昆明理工大学 | Mouthwash for preventing and treating periodontitis and preparation method thereof |
| CN108379152A (en) * | 2018-04-16 | 2018-08-10 | 新乡医学院三全学院 | A kind of oral nursing liquid and preparation method |
| CN110357900A (en) * | 2019-08-02 | 2019-10-22 | 中国科学院新疆理化技术研究所 | A kind of intermediate processing obtaining ellagic acid from pomegranate rind extract |
| CN111346151A (en) * | 2020-04-10 | 2020-06-30 | 广东药科大学 | Application of calyx seu fructus physalis extract in preparing medicine for treating oral ulcer |
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| CN103860423A (en) * | 2012-12-04 | 2014-06-18 | 中国科学院新疆理化技术研究所 | Collutory with bacterial-resisting, inflammation-eliminating and deodorizing functions and preparation method and use of collutory |
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| CN106237337A (en) * | 2016-08-05 | 2016-12-21 | 河南中帅医药科技股份有限公司 | A kind of liquid pharmaceutical formulation anticorrosive composite |
| CN106237337B (en) * | 2016-08-05 | 2019-11-08 | 河南中帅医药科技股份有限公司 | A kind of liquid pharmaceutical formulation anticorrosive composite |
| CN107693430A (en) * | 2017-11-08 | 2018-02-16 | 江西草珊瑚消毒用品有限公司 | Draft nurses one's health antibacterial gargle |
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| CN103860423A (en) | 2014-06-18 |
| CN103860423B (en) | 2015-12-30 |
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