CN107913234B

CN107913234B - Pilose antler grass toothpaste and preparation method thereof

Info

Publication number: CN107913234B
Application number: CN201711269815.XA
Authority: CN
Inventors: 黄辉球; 黄志刚; 叶红斌
Original assignee: Jiuhui Pharmaceutical Co ltd
Current assignee: Jiuhui Pharmaceutical Co ltd
Priority date: 2017-12-05
Filing date: 2017-12-05
Publication date: 2021-08-03
Anticipated expiration: 2037-12-05
Also published as: CN107913234A

Abstract

The invention provides a pilose antler grass toothpaste, which comprises the following components in parts by weight: 3-6 parts of pilose antler grass extract, 2-4 parts of lophatherum gracile extract, 2-4 parts of mint extract and 73-86 parts of toothpaste matrix. The pilea millettii toothpaste has good antibacterial, anti-inflammatory and analgesic effects, and has good oral cavity repairing capability due to strong pertinence to inhibition of pathogenic bacteria; meanwhile, the toothpaste has good treatment effect on stomatitis such as oral ulcer and gingival swelling and pain, and has the advantages of scientific and simple formula, low raw material cost and high cost performance. The invention also provides a preparation method of the pilose antler grass toothpaste, the preparation method is simple and easy to operate, and effective bacteriostatic and bactericidal components in the pilose antler grass and the lophatherum gracile can be fully extracted and protected.

Description

Pilose antler grass toothpaste and preparation method thereof

Technical Field

The invention relates to the technical field of oral care and health care, in particular to a pilose antler grass toothpaste and a preparation method thereof.

Background

Oral inflammation mainly includes ulcerative, herpetic and mycotic stomatitis, oral lichen planus and the like. There is a high possibility of coexistence of various oral inflammations. Among them, recurrent oral ulcer has a high incidence rate and is characterized by periodicity, recurrence and self-limitation. Severe oral ulcer patients may also be accompanied by complications such as swelling and aching of the gums, bleeding gums, and the like.

Along with the enhancement of health consciousness and the improvement of life quality of people, more and more consumers tend to use functional toothpaste which has certain functionality and can solve and improve oral inflammation problems such as oral ulcer, and the Chinese herbal medicine toothpaste containing natural plant extracts is popular among consumers due to warm nature, small stimulation, safety and no toxicity.

In the traditional Chinese medicine toothpaste in the current market, a part of toothpaste has single traditional Chinese medicine type, and the synergistic effect generated by the mutual compatibility of traditional Chinese medicinal materials is not exerted; one part is that the traditional Chinese medicine prescription has too many traditional Chinese medicines, which leads to complex composition of the ingredients and causes the content of the limited active ingredients in the toothpaste to be lower. In addition, the antibacterial active ingredients used by the toothpaste have weak pertinence and broad-spectrum antibacterial property, namely, the toothpaste also has an inhibiting effect on nonpathogenic resident bacteria in the oral cavity and reduces the self-healing capacity of each tissue of the oral cavity to injury.

Therefore, there is a need for a traditional Chinese medicine toothpaste with simple formula and capable of safely and effectively preventing and treating oral inflammation.

Disclosure of Invention

In order to solve the problems in the prior art, the invention provides the pilea pilosula toothpaste which takes the pilea pilosula as the main material and the lophatherum gracile as the auxiliary material and is added with the mint, and the pilea pilosula toothpaste has good antibacterial, anti-inflammatory and analgesic effects and has better oral cavity repairing capability due to strong pertinence to inhibition of pathogenic bacteria; meanwhile, the toothpaste has good treatment effect on stomatitis such as oral ulcer and gingival swelling and pain, and has the advantages of scientific and simple formula, low raw material cost and high cost performance.

In order to achieve the purpose, the invention provides the following technical scheme:

the cervus elaphus linnaeus toothpaste comprises the following components in parts by weight: 3-6 parts of pilose antler grass extract, 2-4 parts of lophatherum gracile extract, 2-4 parts of mint extract and 73-86 parts of toothpaste matrix.

As further described in the technical scheme of the invention, the toothpaste matrix comprises the following components in parts by weight: 27-32 parts of an abrasive, 14-17 parts of an excipient, 28-31 parts of a humectant, 1.2-1.6 parts of a thickening agent, 0.5-1.1 parts of essence, 1.3-1.8 parts of a foaming agent and 1.0-1.5 parts of a sweetening agent.

As further description of the technical scheme of the invention, the composition comprises the following components in parts by weight: 3 parts of pilose antler grass extract, 2 parts of lophatherum gracile extract, 2 parts of mint extract and 80 parts of toothpaste matrix;

the toothpaste matrix comprises the following components in parts by weight:

30 parts of an abrasive, 15 parts of an excipient, 30 parts of a humectant, 1.4 parts of a thickener, 0.8 part of essence, 1.6 parts of a foaming agent and 1.2 parts of a sweetener.

As a further description of the technical scheme of the invention, in the toothpaste matrix, the abrasive is one or a mixture of any several of silicon dioxide, calcium carbonate, calcium bicarbonate and calcium hydrogen phosphate dihydrate; the excipient is sorbitol; the humectant is one or a mixture of any more of glycerol, propylene glycol, polyethylene glycol and sorbitol; the thickening agent is silicon dioxide; the essence is any one of mint essence, bamboo leaf essence, spearmint essence and strawberry essence; the foaming agent is sodium lauryl sulfate; the sweetener is saccharin sodium or aspartame.

In the invention, the velvet antler grass is dry whole herb of velvet antler grass of scrophulariaceae, the Latin has the chemical name of Monochama savatieri Franch, which is also called thousand-year moxa, huperzia serrata, Chinese alpine rush, Chinese pulsatilla and the like, has the efficacies of heat decomposition, detoxification, blood cooling, hemostasis and the like, is mainly used for treating cold, cough, hematemesis, upper respiratory infection and the like in clinic, and is one of main components of Chinese medicinal Yanning granules for protecting variety Yanning. The inventor finds that the water extract of the velvet grass is rich in phenylethanoid glycosides, and simultaneously contains corresponding chlorogenic acid, saponin and flavonoid compounds, and the compounds have good antibacterial effect. Researches show that the phenylethanoid glycosides of the pantoea herb in the extract of the pantoea herb aqueous solution have strong antibacterial activity on staphylococcus aureus, pseudomonas aeruginosa, escherichia coli and helicobacter pylori. Researchers believe that the antibacterial/antimicrobial activity of the pantoea herb phenylethanoid glycoside is attributed to the close relationship between the phenolic hydroxyl and the protein, so that in the preparation of the pantoea herb toothpaste, the phenolic hydroxyl of the phenylethanoid glycoside can be protected in the water extraction process, and the phenolic hydroxyl is prevented from being damaged by introducing an organic solvent.

Lophatherum gracile is the stem and leaf of a perennial herb of the family Gramineae, has the Latin chemical name of Lophatherum gracile, namely, fructus psoraleae, pheasant rice, golden pheasant rice, labyrinthica and the like, is sweet and light in taste, cold in nature and non-toxic, has the effects of clearing heat, relieving restlessness, promoting urination, removing dysphoria and the like, has unique curative effect on mouth and tongue sores, is usually used for preparing decoction by using the stem and leaf thereof, and is used for treating gum swelling and pain, stomatitis and the like. The inventor finds that terpenes, alkaloids, flavonoids, unique amino acids and polysaccharides contained in the water extract of the lophatherum gracile have good antibacterial activity, and particularly, a large amount of flavonoids and bioactive polysaccharides have good inhibitory effect on staphylococcus aureus and hemolytic streptococcus.

The mint is a plant of the genus Mentha of the family Labiatae, has the Latin chemical name of Mentha halopthalyx Briq, is one of the traditional Chinese medicines commonly used in China, is also an important spice plant, and has the main component of menthol. Herba Menthae has effects of dispelling pathogenic wind, clearing heat, and removing toxic substance, and can be used for treating wind-heat type common cold, headache, conjunctival congestion, sore throat and toothache etc., and can be added into toothpaste to refresh breath.

The compound preparation creatively compounds the pilose antler grass water extract and the lophatherum gracile extract, enhances the inhibition and killing effects on oral pathogenic bacteria, and particularly has obvious inhibition and killing effects on staphylococcus aureus and helicobacter pylori causing oral ulcer symptoms; meanwhile, the pilose antler grass can stop bleeding, promote healing of oral inflammation wound surfaces and effectively relieve pain. The cervus elaphus linnaeus and the lophatherum gracile have synergistic interaction, and particularly, the cervus elaphus linnaeus phenylethanoid glycoside and the lophatherum gracile active polysaccharide are mutually matched, so that the oral cavity repairing capacity is good, and the oral inflammation such as oral cavity sore, gum swelling and pain and the like can be well treated.

The formula of the mint is added into the pilea millettii toothpaste, the mint has antibacterial ingredients and curative effects, can relieve toothache and nourish gingiva, and meanwhile, the mint can solve the problem of dead corners of the oral cavity, can clear breath and improve the long-standing halitosis problem.

The toothpaste matrix disclosed by the invention comprises an abrasive, an excipient, a humectant, a thickener, essence, a foaming agent and a sweetening agent, and the matrix components are preferably used as carriers of the antlerpilose grass, the lophatherum gracile and the mint according to the proportion, so that the traditional Chinese medicine components in the raw materials can be fully mixed and dissolved, the paste body becomes fine, compact, bright and uniform in color distribution, and the quality of the paste body is further improved.

As another object of the invention, the invention also provides a preparation method of the pilea pilosula toothpaste, which comprises the following specific steps:

(1) decocting herba Monochasmatis, folium Bambusae and herba Menthae with purified water twice, each time for 1.5 hr, mixing decoctions, filtering, concentrating, and drying to obtain extract;

(2) 3-6 parts of the pilose antler grass extract, 2-4 parts of the lophatherum gracile extract, 2-4 parts of the mint extract and 73-86 parts of the toothpaste matrix by weight, conveying the pilose antler grass extract, the lophatherum gracile extract and the mint extract obtained in the step 1 and the toothpaste matrix into a vacuum mixer for stirring and homogenizing to obtain paste; the stirring and homogenizing time is 20-30 minutes;

(3) sterilizing the paste, and packaging with a composite hose to obtain the pilea piloselloides toothpaste.

In the preparation method, the invention fully extracts and protects the effective antibacterial and bactericidal components in the pilose antler grass and the lophatherum gracile, which has obvious inhibiting and killing effects on staphylococcus aureus and helicobacter pylori causing oral ulcer symptoms.

Based on the technical scheme, the invention has the following technical effects:

(1) the cervus elaphus linnaeus toothpaste provided by the invention has the advantages that the water extracts of the three traditional Chinese medicines of the cervus elaphus linnaeus, the lophatherum gracile and the mint are reasonably compatible, the effective components and the action mechanism are relatively clear, the toothpaste has good antibacterial, anti-inflammatory and analgesic effects, the inhibition pertinence to pathogenic bacteria is strong, and the toothpaste has a relatively small inhibition effect on nonpathogenic resident bacteria, so that the self-healing capacity and the oral cavity repair capacity of oral tissues on damage are effectively improved.

(2) The pilea millettii toothpaste can promote the healing of the wound surface of oral inflammation, thereby having good treatment effect on oral inflammation such as oral ulcer, gum swelling and pain and the like, and having scientific and simple formula, low raw material cost and high cost performance. Compared with the traditional medicinal toothpaste for treating oral ulcer, the toothpaste has the advantages of less side effect and higher safety.

(3) The preparation method of the pilose antler grass toothpaste provided by the invention can fully extract and protect effective bacteriostatic and bactericidal components in the pilose antler grass and the lophatherum gracile, and ensure that effective components in the toothpaste can play a role in inhibiting and killing pathogenic bacteria, thereby effectively preventing and treating stomatitis. The preparation method has the advantages of low cost of raw materials, simple operation, no influence on the activity of the traditional Chinese medicine components, few process steps and contribution to industrial production.

Detailed Description

In order that the invention may be more fully understood, reference will now be made to the specific embodiments illustrated. The invention provides a preferred embodiment. This invention may, however, be embodied in many different forms and should not be construed as limited to the embodiments set forth herein. Rather, these embodiments are provided so that this disclosure will be thorough and complete.

Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. The terminology used herein in the description of the invention is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention.

Example 1

The cervus elaphus linnaeus toothpaste comprises the following components in parts by weight: 3 parts of pilose antler grass extract, 2 parts of lophatherum gracile extract, 2 parts of mint extract and 80 parts of toothpaste matrix;

the toothpaste matrix comprises the following components in parts by weight:

30 parts of abrasive silicon dioxide, 15 parts of excipient sorbitol, 30 parts of humectant polyethylene glycol, 1.4 parts of thickening agent silicon dioxide, 0.8 part of essence bamboo leaf essence, 1.6 parts of foaming agent sodium lauryl sulfate and 1.2 parts of sweetening agent aspartame.

The toothpaste of the embodiment is prepared by the following preparation method, and the preparation method comprises the following specific steps:

(1) respectively decocting herba Monochasmatis, folium Bambusae and herba Menthae with purified water twice, each time for 1.5 hr, mixing decoctions, filtering, concentrating, and drying to obtain extract, which is prepared from herba Monochasmatis extract, folium Bambusae extract and herba Menthae extract.

(2) According to the weight parts of 3 parts of the pilose antler grass extract, 2 parts of the lophatherum herb extract, 2 parts of the mint extract and 80 parts of the toothpaste matrix, the pilose antler grass extract, the lophatherum herb extract and the mint extract obtained in the step 1 and the toothpaste matrix are conveyed into a vacuum mixer to be stirred and homogenized to obtain paste; the stirring and homogenization time was 26 minutes.

(3) And sterilizing the paste, and packaging the paste by using a composite hose to obtain the antlerpilose grass toothpaste of the example 1.

Example 2

The cervus elaphus linnaeus toothpaste comprises the following components in parts by weight: 5 parts of pilose antler grass extract, 3 parts of lophatherum gracile extract, 3 parts of mint extract and 82 parts of toothpaste matrix;

the toothpaste matrix comprises the following components in parts by weight:

31 parts of friction agent calcium hydrophosphate dihydrate, 15 parts of excipient sorbitol, 31 parts of humectant glycerin, 1.4 parts of thickening agent silicon dioxide, 0.8 part of essence mint essence, 1.6 parts of foaming agent sodium lauryl sulfate and 1.2 parts of sweetening agent saccharin sodium.

(1) respectively decocting herba Monochasmatis, folium Bambusae and herba Menthae with purified water twice, each time for 1.6 hr, mixing decoctions, filtering, concentrating, and drying to obtain extract, which is prepared from herba Monochasmatis extract, folium Bambusae extract and herba Menthae extract.

(2) According to the weight parts of 5 parts of the pilose antler grass extract, 3 parts of the lophatherum herb extract, 3 parts of the mint extract and 82 parts of the toothpaste matrix, the pilose antler grass extract, the lophatherum herb extract and the mint extract obtained in the step 1 and the toothpaste matrix are conveyed into a vacuum mixer to be stirred and homogenized to obtain paste; the stirring and homogenization time was 20 minutes.

(3) And sterilizing the paste, and packaging the paste by using a composite hose to obtain the antlerpilose grass toothpaste of the embodiment 2.

Example 3

The cervus elaphus linnaeus toothpaste comprises the following components in parts by weight: 6 parts of pilose antler grass extract, 4 parts of lophatherum gracile extract, 4 parts of mint extract and 86 parts of toothpaste matrix;

the toothpaste matrix comprises the following components in parts by weight:

32 parts of abrasive silicon dioxide, 17 parts of excipient sorbitol, 31 parts of humectant sorbitol, 1.6 parts of thickener silicon dioxide, 1.1 parts of essence bamboo leaf essence, 1.8 parts of foaming agent sodium lauryl sulfate and 1.5 parts of sweetener aspartame.

(1) respectively decocting herba Monochasmatis, folium Bambusae and herba Menthae with purified water twice, each time for 1.7 hr, mixing decoctions, filtering, concentrating, and drying to obtain extract, which is prepared from herba Monochasmatis extract, folium Bambusae extract and herba Menthae extract.

(2) According to the weight parts of 6 parts of the pilose antler grass extract, 4 parts of the lophatherum gracile extract, 4 parts of the mint extract and 86 parts of the toothpaste matrix, the pilose antler grass extract, the lophatherum gracile extract and the mint extract obtained in the step 1 and the toothpaste matrix are conveyed into a vacuum mixer to be stirred and homogenized to obtain paste; the stirring and homogenization time was 30 minutes.

(3) And sterilizing the paste, and packaging the paste by using a composite hose to obtain the antlerpilose grass toothpaste of the embodiment 3.

Comparative example 1 (not containing the extract fraction of Lophatherum gracile)

The toothpaste comprises the following components in parts by weight: 3 parts of pilose antler grass extract, 2 parts of mint extract and 80 parts of toothpaste matrix;

the toothpaste matrix comprises the following components in parts by weight:

(1) decocting herba Monochasmatis and herba Menthae with purified water twice for 1.7 hr, mixing decoctions, filtering, concentrating, and drying to obtain herba Monochasmatis extract and herba Menthae extract.

(2) Conveying the pilose antler grass extract and the mint extract obtained in the step (1) and the toothpaste matrix into a vacuum mixer for stirring and homogenizing according to the weight parts of the pilose antler grass extract 3 parts, the mint extract 2 parts and the toothpaste matrix 80 parts to obtain paste; the stirring and homogenization time was 30 minutes.

(3) The paste was sterilized and then packed in a composite tube to obtain the toothpaste of comparative example 1.

Comparative example 2 (containing no Cervus elaphus Linnaeus extract component)

The toothpaste comprises the following components in parts by weight: 2 parts of lophatherum gracile extract, 2 parts of mint extract and 80 parts of toothpaste matrix;

the toothpaste matrix comprises the following components in parts by weight:

(1) respectively decocting herba Lophatheri and herba Menthae with purified water twice, each time for 1.5 hr, mixing decoctions, filtering, concentrating, and drying to obtain herba Lophatheri extract and herba Menthae extract.

(2) Conveying the lophatherum gracile extract and the mint extract obtained in the step (1) and the toothpaste matrix into a vacuum mixer for stirring and homogenizing according to the weight parts of 2 parts of the lophatherum gracile extract, 2 parts of the mint extract and 80 parts of the toothpaste matrix to obtain a paste; the stirring and homogenization time was 26 minutes.

(3) The paste was sterilized and then packed in a composite tube to obtain the toothpaste of comparative example 2.

Comparative example 3 (not containing the Antlerpilose grass extract component and the Lophatherum gracile extract component)

The toothpaste comprises the following components in parts by weight: 2 parts of mint extract and 80 parts of toothpaste matrix;

the toothpaste matrix comprises the following components in parts by weight:

(1) decocting herba Menthae with purified water twice for 1.5 hr, mixing decoctions, filtering, concentrating, and drying to obtain herba Menthae extract.

(2) Conveying the mint extract and the toothpaste matrix obtained in the step (1) into a vacuum mixer according to the weight parts of 2 parts of the mint extract and 80 parts of the toothpaste matrix, and stirring and homogenizing to obtain paste; the stirring and homogenization time was 26 minutes.

(3) The paste was sterilized and then packed in a composite tube to obtain the toothpaste of comparative example 3.

The above-mentioned antlerpilose grass toothpaste of examples 1-3 and the toothpaste of comparative examples 1-3 were subjected to a drug efficacy test.

1. Antibacterial effect test of toothpaste

The bacteriostatic ability of the prepared toothpaste is determined by adopting a filter paper method, and the selected strains are as follows: staphylococcus aureus, helicobacter pylori, escherichia coli, and pseudomonas aeruginosa; the specific test method is as follows: mixing the strain cultured at 37 deg.C for 24 hr with normal saline to make the content of mixed bacteria reach 10⁵cfu/ml; uniformly coating 0.1ml of bacterial liquid on a beef extract protein solid culture medium, respectively taking 5ul of 6 parts of diluted toothpaste liquid medicine with the concentration of 100mg/ml and sterile water to wet a sterile filter paper sheet with the diameter of 6mm, putting the filter paper sheet on a bacteria coating culture medium, culturing for 24 hours at 37 ℃, observing the diameter of a bacteriostatic zone, preliminarily judging the bacteriostatic ability of the sample, wherein' represents that the bacteriostatic zone is less than 1mm and represents that the toothpaste sample does not have the bacteriostatic zoneAnd (4) bacteriostatic ability. The test results are shown in table 1:

TABLE 1 results of in vitro bacteriostatic test for the antlerpilose grass toothpaste of examples 1-3 and the toothpaste of comparative examples 1-3

As can be seen from table 1, the salviae miltiorrhizae ointment compounded by the salviae miltiorrhizae water extract and the lophatherum gracile water extract has good bacteriostatic effect on staphylococcus aureus, helicobacter pylori, escherichia coli and pseudomonas aeruginosa, and particularly has obvious inhibiting and killing effect on staphylococcus aureus and helicobacter pylori causing oral ulcer; the toothpaste adopting the antlerpilose grass water extract or the lophatherum gracile water extract alone or the toothpaste not added with the antlerpilose grass water extract and the lophatherum gracile water extract has poor inhibition effect on the 4 bacteria. This verifies that in the pilea pilosula toothpaste of examples 1-3, because the pilea pilosula and the lophatherum gracile are synergistic, especially the pilea pilosula phenylethanoid glycosides and the lophatherum gracile active polysaccharides are mutually matched, good bacteriostasis and killing effects are achieved, the inhibition effect on pathogenic bacteria is strong, and accordingly healing of the oral inflammation wound surface can be promoted.

2. Evaluation of curative effect of toothpaste in preventing and treating dental ulcer

300 volunteers with oral ulcer and the same disease date and the same disease degree were selected, wherein 182 men and 118 women were divided into 6 groups of 50 persons, and the toothpaste of the cervus elaphus linnaeus of examples 1-3 and the toothpaste of the control examples 1-3 were used respectively once a day in the morning and at night for a period of 7 days for a suitability test.

The evaluation criteria are as follows:

and (3) curing: the ulcer disappears, and the wound healing rate is higher than 90%;

the effect is shown: the pain disappears, and the wound healing rate is 75-90%;

the method has the following advantages: the pain is relieved, and the wound healing rate is 50-75%;

and (4) invalidation: pain persists with a wound healing rate of less than 50%.

The results of the efficacy evaluation are shown in table 2:

TABLE 2 results of patient suitability test for the antlerpilose grass toothpaste of examples 1-3 and the toothpaste of comparative examples 1-3

Treatment groups	Cure of disease	Show effect	Is effective	Invalidation	Effective rate (%)	Cure rate (%)
							Example 1	41	3	4	2	96	82
Example 2	40	3	4	3	94	80
							Example 3	38	6	3	3	94	76
Comparative example 1	3	6	20	21	58	6
							Comparative example 2	4	4	21	21	58	8
Comparative example 3	2	3	16	29	42	4

As can be seen from table 2, the effective rates of the patients using the pilea millettii toothpaste prepared in examples 1-3 are all above 90%, especially the pilea millettii toothpaste prepared in examples 1 and 2 have cure rates respectively reaching 82% and 80%, and the effect of treating dental ulcer is significant. The effect of treating oral ulcer is not very obvious by singly adopting the antlerpilose grass water extract or the lophatherum gracile water extract or not adding the antlerpilose grass water extract and the lophatherum gracile water extract.

Therefore, the cervicitis pantotrichum toothpaste provided by the above embodiments 1-3 has the advantages that through reasonable compatibility of water extracts of the cervicitis pantotrichum, the lophatherum gracile and the mint, the effective components and the action mechanism are relatively clear, the toothpaste has good antibacterial, anti-inflammatory and analgesic effects, and has strong pertinence to inhibition of pathogenic bacteria and small inhibition effect on nonpathogenic resident bacteria, so that the self-healing capacity and the oral cavity repair capacity of oral tissues to injury are effectively improved. The pilea millettii toothpaste provided by the embodiments 1 to 3 can promote the healing of oral inflammation wound surfaces, so the pilea millettii toothpaste has good treatment effects on oral inflammations such as oral sores and gum swelling and pain, and has the advantages of scientific and simple formula, low raw material cost and high cost performance.

The foregoing is merely exemplary and illustrative of the structures of the present invention, which are described in some detail and detail, and are not to be construed as limiting the scope of the invention. It should be noted that, for a person skilled in the art, several variations and modifications are possible without departing from the inventive concept, and such obvious alternatives fall within the scope of the invention.

Claims

1. The cornua cervi pantotrichum toothpaste is characterized by comprising the following components in parts by weight: 3-6 parts of a pilose antler grass extract, 2-4 parts of a lophatherum gracile extract, 2-4 parts of a mint extract and 73-86 parts of a toothpaste matrix;

the cornu Cervi Pantotrichum extract is water extract of cornu Cervi Pantotrichum which is dried whole plant of cornu Cervi Pantotrichum of Scrophulariaceae of genus cornu Cervi Pantotrichum, and Latin is known as Monochama savatieri Franch;

the Lophatherum gracile extract is a water extract of Lophatherum gracile, the Lophatherum gracile is stems and leaves of perennial herbaceous plants of the family Gramineae, and the Latin is named Lophatherum gracile;

the toothpaste matrix comprises the following components in parts by weight: 27-32 parts of an abrasive, 14-17 parts of an excipient, 28-31 parts of a humectant, 1.2-1.6 parts of a thickening agent, 0.5-1.1 parts of essence, 1.3-1.8 parts of a foaming agent and 1.0-1.5 parts of a sweetening agent;

in the toothpaste matrix, the abrasive is one or a mixture of any more of silicon dioxide, calcium carbonate, calcium bicarbonate and calcium hydrophosphate dihydrate;

the excipient is sorbitol;

the humectant is one or a mixture of any more of glycerol, propylene glycol, polyethylene glycol and sorbitol;

the thickening agent is silicon dioxide;

the essence is any one of mint essence, bamboo leaf essence, spearmint essence and strawberry essence;

the foaming agent is sodium lauryl sulfate;

the sweetener is saccharin sodium or aspartame.

2. A method for preparing the antlerpilose grass toothpaste as claimed in claim 1, which comprises the following steps:

(2) conveying the antlerpilose grass extract, the lophatherum gracile extract and the mint extract obtained in the step 1 and the toothpaste matrix into a vacuum mixer for stirring and homogenizing according to the weight parts of the components in the claim 1 to obtain paste; the stirring and homogenizing time is 20-30 minutes;