CN110787104A - Compound traditional Chinese medicine toothpaste and preparation method and application thereof - Google Patents
Compound traditional Chinese medicine toothpaste and preparation method and application thereof Download PDFInfo
- Publication number
- CN110787104A CN110787104A CN201810947547.0A CN201810947547A CN110787104A CN 110787104 A CN110787104 A CN 110787104A CN 201810947547 A CN201810947547 A CN 201810947547A CN 110787104 A CN110787104 A CN 110787104A
- Authority
- CN
- China
- Prior art keywords
- traditional chinese
- chinese medicine
- compound traditional
- sodium
- toothpaste
- Prior art date
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Classifications
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- A61K8/00—Cosmetics or similar toiletry preparations
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- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/80—Scrophulariaceae (Figwort family)
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- A—HUMAN NECESSITIES
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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Abstract
The invention provides a compound traditional Chinese medicine toothpaste, which comprises the following components in percentage by weight: 1-5% of compound traditional Chinese medicine extract, 40-50% of calcium hydrophosphate dihydrate, 2-4% of silicon dioxide hydrate, 3-5% of sodium dodecyl sulfate, 8-12% of sorbitol, 5-10% of polyethylene glycol-400, 4-6% of propylene glycol, 0.5-1.5% of hydroxyethyl cellulose, 0.2-0.4% of xanthan gum, 0.10-0.20% of sodium benzoate, 0.15-0.30% of sodium pyrotetraphosphate, 0.2-0.6% of glycyrrhizin, 0.05-0.15% of magnolol, 0.3-0.6% of peppermint oil, 0.6-0.8% of essence, 1% of brilliant blue solution 1%, 0.4-0.6% of eugenol, 0.7-0.9% of sodium monofluorophosphate and the balance of deionized water. The compound traditional Chinese medicine toothpaste has strong inhibition pertinence to pathogenic bacteria, has good antibacterial, anti-inflammatory, hemostatic and analgesic effects, and has strong oral cavity repairing capability.
Description
Technical Field
The invention relates to the technical field of traditional Chinese medicine oral care and health care, in particular to compound traditional Chinese medicine toothpaste and a preparation method and application thereof.
Background
Oral inflammation mainly includes ulcerative, herpetic and mycotic stomatitis, oral lichen planus and the like. The existing research shows that the oral inflammation is caused by virus or bacteria, generally caused by pathogenic bacteria such as streptococcus, staphylococcus aureus, escherichia coli and the like, has the characteristics of periodicity, recurrence and self-limitation, and is accompanied with complications such as swelling and aching of gum, bleeding of gum and the like.
Along with the enhancement of health consciousness and the improvement of life quality of people, more and more consumers tend to use functional toothpaste which has certain functionality and can solve and improve the problem of oral inflammation, and the Chinese herbal medicine toothpaste containing natural plant extracts is popular among consumers due to warm nature, small stimulation, safety and no toxic or side effect.
In the traditional Chinese medicine toothpaste in the current market, a part of toothpaste has single traditional Chinese medicine type and single function, and does not exert the synergistic effect generated by the mutual compatibility of traditional Chinese medicines; one part is that the traditional Chinese medicine prescription has too many traditional Chinese medicines, which leads to complex composition of the ingredients and causes the content of the limited active ingredients in the toothpaste to be lower. In addition, the antibacterial active ingredients used by the toothpaste have weak pertinence and broad-spectrum antibacterial property, namely, the toothpaste also has an inhibiting effect on nonpathogenic resident bacteria in the oral cavity and reduces the self-healing capacity of each tissue of the oral cavity to injury.
Therefore, there is a need to develop a traditional Chinese medicine toothpaste which has a reasonable formula, can safely and effectively prevent and treat oral inflammation, and has the functions of stopping bleeding and easing pain.
Disclosure of Invention
In order to solve the problems in the prior art, the invention provides the compound traditional Chinese medicine toothpaste containing the extracts of the three traditional Chinese medicines of the savatier monochasma herb, the dayflower monochasma herb and the spreading hedyotis herb. The compound traditional Chinese medicine toothpaste has strong inhibition pertinence on pathogenic bacteria, has good antibacterial, anti-inflammatory, hemostatic and analgesic effects, and has strong oral cavity repairing capability.
In order to achieve the purpose, the invention provides the following technical scheme:
a compound traditional Chinese medicine toothpaste comprises the following components in percentage by weight:
1-5% of compound traditional Chinese medicine extract, 40-50% of calcium hydrophosphate dihydrate, 2-4% of silicon dioxide hydrate, 3-5% of sodium dodecyl sulfate, 8-12% of sorbitol, 5-10% of polyethylene glycol-400, 4-6% of propylene glycol, 0.5-1.5% of hydroxyethyl cellulose, 0.2-0.4% of xanthan gum, 0.10-0.20% of sodium benzoate, 0.15-0.30% of sodium pyrotetraphosphate, 0.2-0.6% of glycyrrhizin, 0.05-0.15% of magnolol, 0.3-0.6% of peppermint oil, 0.6-0.8% of essence, 1% of brilliant blue solution 1%, 0.4-0.6% of eugenol, 0.7-0.9% of sodium monofluorophosphate and the balance of deionized water.
As further description of the technical scheme of the invention, the compound traditional Chinese medicine toothpaste comprises the following components in percentage by weight:
3% of compound traditional Chinese medicine extract, 45% of calcium hydrophosphate dihydrate, 3% of silicon dioxide hydrate, 3.5% of sodium dodecyl sulfate, 10% of sorbitol, 4007% of polyethylene glycol, 5% of propylene glycol, 1% of hydroxyethyl cellulose, 0.3% of xanthan gum, 0.15% of sodium benzoate, 0.25% of sodium pyrotetraphosphate, 0.5% of glycyrrhizin, 0.1% of magnolol, 0.5% of peppermint oil, 0.6% of essence, 1% of brilliant blue solution, 0.5% of eugenol, 0.8% of sodium monofluorophosphate and the balance of deionized water.
As further description of the technical scheme of the invention, the compound traditional Chinese medicine extract comprises the following components in parts by weight: 6-10 parts of pilose antler grass, 3-5 parts of dayflower and 3-5 parts of spreading hedyotis herb.
As further description of the technical scheme of the invention, the preparation method of the compound traditional Chinese medicine extract comprises the following steps: taking three medicines of the pilose antler grass, the dayflower and the oldenlandia according to the weight parts, adding 6 to 12 times of water, decocting for 1 to 4 times, 0.5 to 3 hours each time, and merging decoction liquid; filtering, concentrating the filtrate to relative density of 0.80-1.20 (85-90 deg.C), adding ethanol to make ethanol content 40-90%, stirring, standing for 6-18 hr, filtering, and concentrating the filtrate to fluid extract with relative density of 1.00-1.20 (85-90 deg.C) to obtain compound Chinese medicinal extract.
As further description of the technical scheme of the invention, the preparation method of the compound traditional Chinese medicine extract comprises the following steps: taking three medicines of the savatier monochasma herb, the dayflower monochasma herb and the oldenlandia diffusa according to parts by weight, adding 6-12 times of ethanol for refluxing for 1-4 times, each time for 0.5-3 hours, merging decoction, filtering, concentrating filtrate to obtain clear paste with the relative density of 0.80-1.20 (60-75 ℃), and obtaining the compound traditional Chinese medicine extract.
In the compound traditional Chinese medicine toothpaste, the velvet grass is dry whole herb of velvet grass of the genus velvet grass of the family scrophulariaceae, the Latin has the chemical name of monochama saveri Franch and is also called thousand years moxa, thousand Chinese artichoke, Chinese alpine rush, Chinese pulsatilla root and the like, has the effects of clearing heat and detoxicating, cooling blood and stopping bleeding and the like, is clinically used for treating cold, upper respiratory tract infection, gum swelling and pain and the like, and is one of main components of traditional Chinese medicine Yanning granules for protecting variety inflammation.
The inventor finds that the water/ethanol extract and the ethanol extract of the velvet grass are rich in phenylethanoid glycosides, and simultaneously contain corresponding chlorogenic acid, saponin and flavonoid compounds, and the compounds have good antibacterial effect. The phenylethanoid glycosides of the pantoea herb have strong antibacterial activity against staphylococcus aureus, pseudomonas aeruginosa, escherichia coli and helicobacter pylori. The antibacterial and antimicrobial activities of the pantocrine phenylethanoid glycosides are attributed to the close relationship between the phenolic hydroxyl and the protein, so that in the preparation of the toothpaste, the phenolic hydroxyl of the phenylethanoid glycosides can be protected in a water/ethanol extraction system and an ethanol reflux extraction system, and the phenolic hydroxyl is prevented from being damaged by introducing other solvents.
Commelina communis is dry aerial part of Commelina communis L.of Commelinaceae. It is sweet, bland and cold in nature and taste, has the effects of clearing away heat and toxic material, inducing diuresis and relieving swelling, and can be used for treating wind-heat type common cold, hyperpyrexia, sore throat, edema, oliguria, stranguria with heat, pain, carbuncle, furuncle, etc. The water/ethanol extract and the ethanol extract of the dayflower are rich in p-hydroxycinnamic acid, have strong antibacterial activity on staphylococcus aureus, staphylococcus albus, escherichia coli and typhoid bacillus, and have obvious inhibition effect on pathogenic bacteria causing oral inflammation when being applied to toothpaste.
Oldenlandia diffusa is the whole plant of Oldenlandia diffusa of the genus Oldenlandia of the family rubiaceae, and has the latin scientific name of hedyotis diffusa willld. [ Oldenlandia diffusa (Willd.) ] Roxb. It has sweet, light and cool nature and taste, and has effects of clearing away heat and toxic materials, inducing diuresis to alleviate edema, promoting blood circulation and relieving pain. The traditional Chinese medicine composition is clinically used for treating intestinal carbuncle (appendicitis), sore and furuncle pyogenic infections, damp-heat jaundice, dysuria and other symptoms; it is externally used for treating sore, furuncle, carbuncle, swelling, and venomous snake bite. The water/ethanol extract and the ethanol extract of the oldenlandia diffusa contain flavonoids and organic acid compounds, have strong antibacterial activity on staphylococcus aureus, pseudomonas aeruginosa and escherichia coli, and have obvious inhibiting effect on pathogenic bacteria causing oral inflammation when being applied to toothpaste.
The invention creatively combines the three traditional Chinese medicines of the pilose antler grass, the dayflower and the oldenlandia diffusa, extracts in the same extraction system to obtain the compound traditional Chinese medicine extract containing the pilose antler grass extract, the dayflower extract and the oldenlandia diffusa extract, the compound traditional Chinese medicine extract is rich in antibacterial active ingredients, the three are reasonably compatible to play a role in synergy, the compound traditional Chinese medicine toothpaste has better oral cavity repairing capability, and the prepared compound traditional Chinese medicine toothpaste has good antibacterial effect.
In the toothpaste matrix, calcium hydrogen phosphate dihydrate, silicon dioxide hydrate, sodium dodecyl sulfate, sorbitol, polyethylene glycol-400, propylene glycol, hydroxyethyl cellulose, xanthan gum, essence and the like are included, and the proportion of the matrix components is optimized to be used as a carrier of the savatier monochasma herb, the dayflower herb and the oldenlandia diffusa, so that the traditional Chinese medicine components in the raw materials can be fully mixed and dissolved, the paste is fine, compact, bright and uniform in color distribution, and the quality of the paste is further improved.
As further description of the technical scheme of the invention, the essence is one or more of fruit essence, tea essence and drug essence. The essence can clean halitosis, and improve halitosis.
The invention also provides a preparation method of the compound traditional Chinese medicine toothpaste, which comprises the following steps:
(1) dissolving hydroxyethyl cellulose and xanthan gum in sorbitol, and uniformly stirring to obtain an intermediate A;
(2) sodium benzoate, sodium pyrotetraphosphate, sodium monofluorophosphate and glycyrrhizin are taken to be put into deionized water and stirred to be completely dissolved, so as to obtain an intermediate B;
(3) adding the intermediate B into the intermediate A, stirring while adding, and standing to fully expand to obtain an intermediate C;
(4) adding magnolol, Mentholum, and compound Chinese medicinal extract into polyethylene glycol-400 and propylene glycol, stirring to dissolve completely to obtain intermediate D;
(5) adding the intermediate D into the intermediate C, stirring, adding calcium hydrogen phosphate dihydrate, silicon dioxide hydrate, xanthan gum, Glycyrrhrizae radix essence, eugenol and 1% brilliant blue solution, stirring, grinding, vacuum degassing, and packaging.
In the preparation method, the invention fully extracts and protects the effective bacteriostatic and bactericidal components in the pilose antler grass, the dayflower and the oldenlandia diffusa, which has obvious inhibiting and killing effects on pathogenic bacteria causing oral cavity.
The invention also provides the compound traditional Chinese medicine toothpaste and application of the compound traditional Chinese medicine toothpaste prepared by the preparation method of the compound traditional Chinese medicine toothpaste in preventing and treating oral inflammation.
Based on the technical scheme, the invention has the following technical effects:
(1) according to the compound traditional Chinese medicine toothpaste provided by the invention, extracts of the three traditional Chinese medicines of the savatier monochasma herb, the dayflower and the oldenlandia diffusa are reasonably compatible, so that the toothpaste has good antibacterial, anti-inflammatory and analgesic effects, has strong pertinence to inhibition of pathogenic bacteria, and has a small inhibition effect on nonpathogenic resident bacteria, thereby effectively improving self-healing capacity and oral cavity repair capacity of oral tissues to injury.
(2) The compound traditional Chinese medicine toothpaste can promote the healing of the wound surface of oral inflammation, thereby having good treatment effect on oral inflammation such as oral ulcer, gum swelling and pain and the like, and having scientific and simple formula, low raw material cost and high cost performance. Compared with the traditional medicinal toothpaste for treating oral inflammation, the toothpaste has the advantages of less side effect and higher safety.
(3) The preparation method of the compound traditional Chinese medicine toothpaste provided by the invention can fully extract and protect effective bacteriostatic and bactericidal components in the savatier monochasma herb, the dayflower monochasma herb and the oldenlandia diffusa, and ensure that effective components in the toothpaste can play the role of inhibiting and killing pathogenic bacteria, thereby effectively preventing and treating oral inflammation. The preparation method has the advantages of low cost of raw materials, simple operation, no influence on the activity of the traditional Chinese medicine components, few process steps and contribution to industrial production.
Detailed Description
In order that the invention may be more fully understood, reference will now be made to the specific embodiments illustrated. The invention provides a preferred embodiment. This invention may, however, be embodied in many different forms and should not be construed as limited to the embodiments set forth herein. Rather, these embodiments are provided so that this disclosure will be thorough and complete.
Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. The terminology used herein in the description of the invention is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention.
Example 1
A compound traditional Chinese medicine toothpaste comprises the following components in percentage by weight:
3% of compound traditional Chinese medicine extract, 45% of calcium hydrophosphate dihydrate, 3% of silicon dioxide hydrate, 3.5% of sodium dodecyl sulfate, 10% of sorbitol, 4007% of polyethylene glycol, 5% of propylene glycol, 1% of hydroxyethyl cellulose, 0.3% of xanthan gum, 0.15% of sodium benzoate, 0.25% of sodium pyrotetraphosphate, 0.5% of glycyrrhizin, 0.1% of magnolol, 0.5% of peppermint oil, 0.6% of essence, 1% of brilliant blue solution, 0.5% of eugenol, 0.8% of sodium monofluorophosphate and the balance of deionized water.
The preparation method of the compound traditional Chinese medicine extract comprises the following steps: taking 8 parts of pilose antler grass, 4 parts of dayflower and 4 parts of spreading hedyotis herb according to the parts by weight, adding 9 times of water, decocting for 2 times, each time for 2 hours, and combining the decoctions; filtering, concentrating the filtrate to relative density of 1.0 (85-90 deg.C), adding ethanol to make ethanol content 70%, stirring, standing for 12 hr, filtering, and concentrating the filtrate to fluid extract with relative density of 1.10 (85-90 deg.C) to obtain compound Chinese medicinal extract.
The preparation method of the compound traditional Chinese medicine toothpaste specifically comprises the following steps:
(1) dissolving hydroxyethyl cellulose and xanthan gum in sorbitol, and uniformly stirring to obtain an intermediate A;
(2) sodium benzoate, sodium pyrotetraphosphate, sodium monofluorophosphate and glycyrrhizin are taken to be put into deionized water and stirred to be completely dissolved, so as to obtain an intermediate B;
(3) adding the intermediate B into the intermediate A, stirring while adding, and standing to fully expand to obtain an intermediate C;
(4) adding magnolol, Mentholum, and compound Chinese medicinal extract into polyethylene glycol-400 and propylene glycol, stirring to dissolve completely to obtain intermediate D;
(5) adding the intermediate D into the intermediate C, stirring, adding calcium hydrogen phosphate dihydrate, silicon dioxide hydrate, xanthan gum, Glycyrrhrizae radix essence, eugenol and 1% brilliant blue solution, stirring, grinding, vacuum degassing, and packaging.
Example 2
A compound traditional Chinese medicine toothpaste comprises the following components in percentage by weight:
1% of compound traditional Chinese medicine extract, 40% of calcium hydrophosphate dihydrate, 2% of silicon dioxide hydrate, 3% of sodium dodecyl sulfate, 8% of sorbitol, 5% of polyethylene glycol-4005%, 4% of propylene glycol, 0.5% of hydroxyethyl cellulose, 0.2% of xanthan gum, 0.10% of sodium benzoate, 0.15% of sodium pyrotetraphosphate, 0.2% of glycyrrhizin, 0.05% of magnolol, 0.3% of peppermint oil, 0.6% of essence, 1% of brilliant blue solution, 0.4% of eugenol, 0.7% of sodium monofluorophosphate and the balance of deionized water.
The preparation method of the compound traditional Chinese medicine extract comprises the following steps: taking 6 parts of savatier monochasma herb, 3 parts of dayflower herb and 3 parts of spreading hedyotis herb according to the parts by weight, adding 6 times of water, decocting for 1 time and 0.5 hour, filtering, concentrating the filtrate until the relative density is 0.80 (85-90 ℃), adding ethanol until the alcohol content is 40%, stirring uniformly, standing for 6 hours, filtering, concentrating the filtrate into clear paste with the relative density of 1.00 (85-90 ℃), and obtaining the compound traditional Chinese medicine extract.
The preparation method of the compound traditional Chinese medicine toothpaste specifically comprises the following steps:
(1) dissolving hydroxyethyl cellulose and xanthan gum in sorbitol, and uniformly stirring to obtain an intermediate A;
(2) sodium benzoate, sodium pyrotetraphosphate, sodium monofluorophosphate and glycyrrhizin are taken to be put into deionized water and stirred to be completely dissolved, so as to obtain an intermediate B;
(3) adding the intermediate B into the intermediate A, stirring while adding, and standing to fully expand to obtain an intermediate C;
(4) adding magnolol, Mentholum, and compound Chinese medicinal extract into polyethylene glycol-400 and propylene glycol, stirring to dissolve completely to obtain intermediate D;
(5) adding the intermediate D into the intermediate C, stirring, adding calcium hydrogen phosphate dihydrate, silicon dioxide hydrate, xanthan gum, Glycyrrhrizae radix essence, eugenol and 1% brilliant blue solution, stirring, grinding, vacuum degassing, and packaging.
Example 3
A compound traditional Chinese medicine toothpaste comprises the following components in percentage by weight:
5% of compound traditional Chinese medicine extract, 50% of calcium hydrophosphate dihydrate, 4% of silicon dioxide hydrate, 5% of sodium dodecyl sulfate, 12% of sorbitol, 10% of polyethylene glycol-40010%, 6% of propylene glycol, 1.5% of hydroxyethyl cellulose, 0.4% of xanthan gum, 0.20% of sodium benzoate, 0.30% of sodium pyrotetraphosphate, 0.6% of glycyrrhizin, 0.15% of magnolol, 0.6% of peppermint oil, 0.8% of essence, 1% of brilliant blue solution, 0.6% of eugenol, 0.9% of sodium monofluorophosphate and the balance of deionized water.
The preparation method of the compound traditional Chinese medicine extract comprises the following steps: taking 10 parts of savatier monochasma herb, 5 parts of dayflower herb and 5 parts of spreading hedyotis herb according to the parts by weight, adding 12 times of ethanol for refluxing for 4 times, 3 hours each time, merging decoction, filtering, and concentrating filtrate to obtain clear paste with the relative density of 1.00 (60-75 ℃) to obtain the compound traditional Chinese medicine extract.
The preparation method of the compound traditional Chinese medicine toothpaste specifically comprises the following steps:
(1) dissolving hydroxyethyl cellulose and xanthan gum in sorbitol, and uniformly stirring to obtain an intermediate A;
(2) sodium benzoate, sodium pyrotetraphosphate, sodium monofluorophosphate and glycyrrhizin are taken to be put into deionized water and stirred to be completely dissolved, so as to obtain an intermediate B;
(3) adding the intermediate B into the intermediate A, stirring while adding, and standing to fully expand to obtain an intermediate C;
(4) adding magnolol, Mentholum, and compound Chinese medicinal extract into polyethylene glycol-400 and propylene glycol, stirring to dissolve completely to obtain intermediate D;
(5) adding the intermediate D into the intermediate C, stirring, adding calcium hydrogen phosphate dihydrate, silicon dioxide hydrate, xanthan gum, Glycyrrhrizae radix essence, eugenol and 1% brilliant blue solution, stirring, grinding, vacuum degassing, and packaging.
Example 4
A compound traditional Chinese medicine toothpaste comprises the following components in percentage by weight:
2% of compound traditional Chinese medicine extract, 35% of calcium hydrophosphate dihydrate, 2.5% of silicon dioxide hydrate, 4.5% of sodium dodecyl sulfate, 11% of sorbitol, 6% of polyethylene glycol-4006%, 4.5% of propylene glycol, 0.8% of hydroxyethyl cellulose, 0.25% of xanthan gum, 0.16% of sodium benzoate, 0.24% of sodium pyrotetraphosphate, 0.35% of glycyrrhizin, 0.12% of magnolol, 0.4% of peppermint oil, 0.7% of essence, 1% of brilliant blue solution, 0.4% of eugenol, 0.85% of sodium monofluorophosphate and the balance of deionized water.
The preparation method of the compound traditional Chinese medicine extract comprises the following steps: taking 7 parts of savatier monochasma herb, 4.2 parts of dayflower herb and 3.5 parts of spreading hedyotis herb according to the parts by weight, adding 7 times of water, decocting for 3 times, 13 hours each time, filtering, concentrating the filtrate until the relative density is 0.88 (85-95 ℃), adding ethanol until the ethanol content is 60%, stirring uniformly, standing for 10 hours, filtering, concentrating the filtrate into clear paste with the relative density of 1.08 (85-90 ℃), and obtaining the compound traditional Chinese medicine extract.
The preparation method of the compound traditional Chinese medicine toothpaste specifically comprises the following steps:
(1) dissolving hydroxyethyl cellulose and xanthan gum in sorbitol, and uniformly stirring to obtain an intermediate A;
(2) sodium benzoate, sodium pyrotetraphosphate, sodium monofluorophosphate and glycyrrhizin are taken to be put into deionized water and stirred to be completely dissolved, so as to obtain an intermediate B;
(3) adding the intermediate B into the intermediate A, stirring while adding, and standing to fully expand to obtain an intermediate C;
(4) adding magnolol, Mentholum, and compound Chinese medicinal extract into polyethylene glycol-400 and propylene glycol, stirring to dissolve completely to obtain intermediate D;
(5) adding the intermediate D into the intermediate C, stirring, adding calcium hydrogen phosphate dihydrate, silicon dioxide hydrate, xanthan gum, Glycyrrhrizae radix essence, eugenol and 1% brilliant blue solution, stirring, grinding, vacuum degassing, and packaging.
Example 5
A compound traditional Chinese medicine toothpaste comprises the following components in percentage by weight:
4% of compound traditional Chinese medicine extract, 33% of calcium hydrophosphate dihydrate, 3% of silicon dioxide hydrate, 4.5% of sodium dodecyl sulfate, 11% of sorbitol, 4007% of polyethylene glycol, 5.5% of propylene glycol, 0.9% of hydroxyethyl cellulose, 0.28% of xanthan gum, 0.18% of sodium benzoate, 0.23% of sodium pyrotetraphosphate, 0.5% of glycyrrhizin, 0.09% of magnolol, 0.36% of peppermint oil, 0.65% of essence, 1% of brilliant blue solution, 0.48% of eugenol, 0.79% of sodium monofluorophosphate and the balance of deionized water.
The preparation method of the compound traditional Chinese medicine extract comprises the following steps: taking 6 parts of savatier monochasma herb, 4 parts of dayflower herb and 4 parts of spreading hedyotis herb according to the parts by weight, adding 8 times of ethanol for refluxing for 2 times, wherein each time lasts for 1.5 hours, merging decoction, filtering, and concentrating filtrate into clear paste with the relative density of 1.08 (60-75 ℃) to obtain the compound traditional Chinese medicine extract.
The preparation method of the compound traditional Chinese medicine toothpaste specifically comprises the following steps:
(1) dissolving hydroxyethyl cellulose and xanthan gum in sorbitol, and uniformly stirring to obtain an intermediate A;
(2) sodium benzoate, sodium pyrotetraphosphate, sodium monofluorophosphate and glycyrrhizin are taken to be put into deionized water and stirred to be completely dissolved, so as to obtain an intermediate B;
(3) adding the intermediate B into the intermediate A, stirring while adding, and standing to fully expand to obtain an intermediate C;
(4) adding magnolol, Mentholum, and compound Chinese medicinal extract into polyethylene glycol-400 and propylene glycol, stirring to dissolve completely to obtain intermediate D;
(5) adding the intermediate D into the intermediate C, stirring, adding calcium hydrogen phosphate dihydrate, silicon dioxide hydrate, xanthan gum, Glycyrrhrizae radix essence, eugenol and 1% brilliant blue solution, stirring, grinding, vacuum degassing, and packaging.
Example 6 effectiveness test
Content of research
The compound traditional Chinese medicine toothpaste of example 1 was studied for its anti-inflammatory, analgesic and hemostatic effects.
Second, experimental methods and results
(I) test materials
The tested drugs are: example 1 a toothpaste; a blank matrix prepared by the compound traditional Chinese medicine extract is not added according to the prescription of the toothpaste in the embodiment 1; yunnan Baiyao toothpaste.
Experimental animals: rabbit, Kunming mouse.
Reagent: formaldehyde solution, analytical grade 20111007, Guangdong Guanghua science & technology, Inc.; absolute ethanol, analytically pure, lot number 20110416, tianjin advanced chemical Limited; xylene, analytical grade, lot No. 20101224, Guangdong Guanghua Chemicals Co., Ltd; hematoxylin, biological stainin, batch number 20160408, Fluka import of Beijing Dingguo Biotechnology Limited liability company; eosin Y, bioshrombin, lot No. 20160912, chemical plant of east china university; OLYMPUSAU5421 model full-automatic biochemical analyzer, manufactured by OLYMPUS corporation of Japan; OLYMPUS BH-2 fluorescence microscope, manufactured by OLYMPUS corporation of Japan; model beckman 30 low temperature centrifuge, manufactured by BACKMAN corporation, usa; LEICA RM2135 microtome, manufactured by LEICA, Germany; SARTORIUS electronic balance, manufactured by SARTORIUS company, germany.
(II) Experimental methods and results
1. Hemostatic action
White rabbit with weight of 2.0-2.5kg is used for male and female. Slowly injecting into ear vein of 30 mg/kg of 3% sodium pentobarbital, anesthetizing, supine fixing on operating table, making the middle incision of abdomen about 6-8cm long, exposing and fixing liver, cutting liver left lobe with surgical scissors to cut liver tissue about 1cm long, 1cm wide and 1cm high, and making wound surface bleed. After the ejected blood is wiped off, the wound surface is immediately coated with the sample lg of the test object, covered with gauze and pressed for 1min by a weight of 200 g. Removing the weight after 1min, observing hemostatic effect, taking no bleeding as hemostasis, applying sample to be tested, pressurizing, observing every 30s, and recording hemostasis time. If bleeding still occurred for more than 3min, the bleeding is not stopped, and the bleeding stopping time is >3 min. After each sample test, the residual test substance is washed away by physiological saline at 37 ℃ so that the wound surface bleeds again, and then the next test substance sample is tested. Each rabbit was subjected to 4 hemostasis tests for liver local wound injury, and each test sample was applied according to the latin formula to reduce the effect of the difference in cut and the order of application of the drugs on liver local wound injury. The hemostatic experiment of the rabbit liver local wound injury bleeding is carried out for 20 times in total for each test object sample. The hemostatic effect is marked as F by the reciprocal score method (10/T), hemostasis is not achieved for more than 3min, and no F score is marked as 0. The results are reported in Table 1 and analyzed by statistical t-test.
TABLE 1 hemostatic effect of toothpaste samples on rabbit liver local wound bleeding (X + -SD)
| Group of | Number of experiments | Hemostasis time (min) | Score value (F) |
| Starch group | 20 | >3 | |
| Toothpaste blank matrix group | 20 | >3 | |
| Yunnan Baiyao group | 20 | 1.68±0.34*# | 5.53±0.82*# |
| EXAMPLE 1 toothpaste | 20 | 1.80±0.29*# | 4.98±0.69*# |
# comparison with starch group: p < 0.05;
comparison with toothpaste blank matrix: p <0.05
The above results show that: the toothpaste and the Yunnan white drug powder toothpaste group in the example 1 have obvious hemostatic effect on the local wound injury bleeding of the rabbit liver, and the two groups have obvious difference (P <0.05) compared with a toothpaste blank control group, so that the toothpaste in the example 1 has significance statistically, and the toothpaste in the example 1 has obvious hemostatic effect.
2. Anti-inflammatory action
Taking 30 healthy male Kunming-breed mice with the weight of 18-22 g, and dividing 3 groups at random, wherein each group comprises 10 mice. In the experiment, 0.1ml of dimethylbenzene is uniformly coated on the inner side and the outer side of the auricle of the right ear of each animal in each group to cause inflammation, and the left ear is not treated to be used as a self blank control. After coating dimethylbenzene for 30min, 0.1g of each group of test substance samples is uniformly coated on the inner surface and the outer surface of the right auricle of each animal in each group respectively. After the administration of lh, the mice were sacrificed by dislocation of cervical vertebrae, the two auricles were cut off, the right auricle test substance sample was washed off with physiological saline, the two auricles were wiped off with a dry cotton ball, the two auricles were overlapped, two round ear pieces were chiseled at the same site with a punch having an inner diameter of 8mm, and the two round ear pieces were weighed on an electronic analytical balance, respectively, and the weight of the right ear piece minus the weight of the left ear piece was taken as a swelling value. The results are shown in Table 2.
TABLE 2 influence of samples on acute inflammation swelling of mouse auricles caused by Paralyne (X. + -. SD)
| Group of | Dosage (g/only) | Swelling value of auricle (mg) |
| Blank control group | 0.1 | 17.03±7.68 |
| Toothpaste blank matrix group | 0.1 | 15.51±5.92 |
| EXAMPLE 1 toothpaste | 0.1 | 12.53±4.69**## |
Comparison with blank control group: p <0.05, compared to toothpaste blank matrix: p < 0.05;
# vs blank control: p <0.01, compared to toothpaste blank matrix: p <0.01
The above results show that: the toothpaste in the embodiment 1 can obviously reduce the weight of mouse auricles with acute inflammation and swelling, and can obviously inhibit the mouse auricles with acute inflammation and swelling caused by xylene.
3. Analgesic effect
Selecting healthy Kunming mice with the weight of 18-22 g, adjusting and controlling the temperature to be 55 +/-0.5 ℃ by using a hot plate pain measuring instrument, placing the mice on a hot plate to measure the pain threshold value of each mouse (the time from the contact of the mice with the hot plate to the foot licking of the mice), discarding the mice when the foot licking time is less than 5 seconds or more than 30 seconds and skips, selecting 40 qualified mice, randomly dividing into 4 groups, and respectively using 10 mice in each group for a blank control group, a toothpaste blank matrix group, a positive diclofenac diethylamine emulsion and the toothpaste in the embodiment 1. The normal pain threshold of each group of mice is determined by repeating the method for 2 times, the interval of each time is 15min, and the average value of the two normal pain thresholds is taken as the pain threshold of the group of mice before administration. Respectively coating 0.2 g/mouse of corresponding tested medicine on 4 foot soles of each mouse of each group of animals, coating 0.2 ml/mouse of physiological saline on a blank control group, coating the medicines for 15min, 30min and 45min, respectively measuring the pain threshold of the mice by the same method, if the mice still have no reaction within 60 seconds(s), taking out the mice to avoid scalding, calculating the pain threshold value within 60 seconds(s), adopting a mouse hot plate method to perform analgesia on a tested toothpaste sample, recording the pain threshold value of each group of mice, and performing statistical t test on data. The results are shown in Table 3.
TABLE 3 analgesic Effect of samples on mice (Hot plate method) (X + -SD)
Comparison with blank control group: p <0.05, compared to toothpaste blank matrix: p <0.05
The results show that the toothpaste of example 1 has a certain degree of analgesic effect.
Third, conclusion
The toothpaste of example 1 has strong hemostatic, anti-inflammatory and analgesic effects.
The foregoing is merely exemplary and illustrative of the structures of the present invention, which are described in some detail and detail, and are not to be construed as limiting the scope of the invention. It should be noted that, for a person skilled in the art, several variations and modifications are possible without departing from the inventive concept, and such obvious alternatives fall within the scope of the invention.
Claims (8)
1. The compound traditional Chinese medicine toothpaste is characterized by comprising the following components in percentage by weight:
1-5% of compound traditional Chinese medicine extract, 40-50% of calcium hydrophosphate dihydrate, 2-4% of silicon dioxide hydrate, 3-5% of sodium dodecyl sulfate, 8-12% of sorbitol, 5-10% of polyethylene glycol-400, 4-6% of propylene glycol, 0.5-1.5% of hydroxyethyl cellulose, 0.2-0.4% of xanthan gum, 0.10-0.20% of sodium benzoate, 0.15-0.30% of sodium pyrotetraphosphate, 0.2-0.6% of glycyrrhizin, 0.05-0.15% of magnolol, 0.3-0.6% of peppermint oil, 0.6-0.8% of essence, 1% of brilliant blue solution 1%, 0.4-0.6% of eugenol, 0.7-0.9% of sodium monofluorophosphate and the balance of deionized water.
2. The compound traditional Chinese medicine toothpaste according to claim 1, which is characterized by comprising the following components in percentage by weight:
3% of compound traditional Chinese medicine extract, 45% of calcium hydrophosphate dihydrate, 3% of silicon dioxide hydrate, 3.5% of sodium dodecyl sulfate, 10% of sorbitol, 4007% of polyethylene glycol, 5% of propylene glycol, 1% of hydroxyethyl cellulose, 0.3% of xanthan gum, 0.15% of sodium benzoate, 0.25% of sodium pyrotetraphosphate, 0.5% of glycyrrhizin, 0.1% of magnolol, 0.5% of peppermint oil, 0.6% of essence, 1% of brilliant blue solution, 0.5% of eugenol, 0.8% of sodium monofluorophosphate and the balance of deionized water.
3. The compound traditional Chinese medicine toothpaste according to claim 1, wherein the compound traditional Chinese medicine extract comprises the following components in parts by weight: 6-10 parts of pilose antler grass, 3-5 parts of dayflower and 3-5 parts of spreading hedyotis herb.
4. The compound traditional Chinese medicine toothpaste according to claim 3, wherein the preparation method of the compound traditional Chinese medicine extract comprises the following steps: taking three medicines of the pilose antler grass, the dayflower and the oldenlandia according to the weight parts, adding 6 to 12 times of water, decocting for 1 to 4 times, 0.5 to 3 hours each time, and merging decoction liquid; filtering, concentrating the filtrate to relative density of 0.80-1.20 (85-90 deg.C), adding ethanol to make ethanol content 40-90%, stirring, standing for 6-18 hr, filtering, and concentrating the filtrate to fluid extract with relative density of 1.00-1.20 (85-90 deg.C) to obtain compound Chinese medicinal extract.
5. The compound traditional Chinese medicine toothpaste according to claim 3, wherein the preparation method of the compound traditional Chinese medicine extract comprises the following steps: taking three medicines of the savatier monochasma herb, the dayflower monochasma herb and the oldenlandia diffusa according to parts by weight, adding 6-12 times of ethanol for refluxing for 1-4 times, each time for 0.5-3 hours, merging decoction, filtering, concentrating filtrate to obtain clear paste with the relative density of 0.80-1.20 (60-75 ℃), and obtaining the compound traditional Chinese medicine extract.
6. The compound traditional Chinese medicine toothpaste according to claim 1, wherein the essence is one or more of fruit essence, tea essence and drug essence.
7. A method for preparing the compound traditional Chinese medicine toothpaste as claimed in any one of claims 1 to 6, which is characterized by comprising the following steps:
(1) dissolving hydroxyethyl cellulose and xanthan gum in sorbitol, and uniformly stirring to obtain an intermediate A;
(2) sodium benzoate, sodium pyrotetraphosphate, sodium monofluorophosphate and glycyrrhizin are taken to be put into deionized water and stirred to be completely dissolved, so as to obtain an intermediate B;
(3) adding the intermediate B into the intermediate A, stirring while adding, and standing to fully expand to obtain an intermediate C;
(4) adding magnolol, Mentholum, and compound Chinese medicinal extract into polyethylene glycol-400 and propylene glycol, stirring to dissolve completely to obtain intermediate D;
(5) adding the intermediate D into the intermediate C, stirring, adding calcium hydrogen phosphate dihydrate, silicon dioxide hydrate, xanthan gum, Glycyrrhrizae radix essence, eugenol and 1% brilliant blue solution, stirring, grinding, vacuum degassing, and packaging.
8. The use of the compound traditional Chinese medicine toothpaste as claimed in any one of claims 1 to 6 or the compound traditional Chinese medicine toothpaste prepared by the preparation method of the compound traditional Chinese medicine toothpaste as claimed in claim 7 in preventing and treating stomatitis.
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| CN113768837A (en) * | 2021-09-16 | 2021-12-10 | 甘肃中医药大学 | A kind of traditional Chinese medicine toothpaste and preparation method thereof |
| CN117323313A (en) * | 2023-10-13 | 2024-01-02 | 深圳雾芯科技有限公司 | Selective antibacterial composition, application thereof and oral care product |
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