CN106562921B

CN106562921B - A liquid oral composition containing Chinese medicinal active substances and tea tree essential oil

Info

Publication number: CN106562921B
Application number: CN201610943361.9A
Authority: CN
Inventors: 李浩然
Original assignee: Individual
Current assignee: Individual
Priority date: 2016-11-02
Filing date: 2016-11-02
Publication date: 2020-11-24
Anticipated expiration: 2036-11-02
Also published as: CN106562921A

Abstract

The invention provides a liquid oral composition containing traditional Chinese medicine active substances and tea tree essential oil, which comprises the following components in parts by weight: 1.0-10 parts of traditional Chinese medicine extract, 0.1-6 parts of additive, 0.001-0.005 part of menthol, 0.001-0.006 part of tea tree essential oil and 90-100 parts of water; wherein the Chinese medicinal extract comprises green tea extract, herba Gnaphalii affinis extract, herba plantaginis extract, herba Lamii Barbati extract, tea tree root extract, Galla chinensis, flos Lonicerae and pericarpium Citri Junoris mixed extract, and violet extract; the additives include wetting agents, pH regulators, preservatives, fragrances and flocculants.

Description

A liquid oral composition containing Chinese medicinal active substances and tea tree essential oil

Technical Field

The invention relates to the technical field of oral care products, and particularly provides a liquid oral composition containing traditional Chinese medicine active substances and tea tree essential oil.

Background

The mouth wash in the liquid oral composition is an oral care product for cleaning and health care in daily life of people, and is mainly used for keeping the oral cavity and teeth clean, promoting breath freshening, nursing gingiva, maintaining good microenvironment of the oral cavity and the like.

At present, the traditional Chinese medicine mouth wash which is commonly used in the market has a plurality of types, and the traditional Chinese medicine mouth wash is mainly formed by adding corresponding traditional Chinese medicine components into a mouth wash water body matrix which forms the mouth wash, and is used for inhibiting harmful bacteria in oral cavity, diminishing inflammation, easing pain, preventing body desensitization, preventing decayed teeth, and preventing and treating periodontal diseases such as gingivitis, periodontitis, tooth bleeding and the like.

To impart a refreshing feeling in use, ethanol is usually mixed in mouthwash. However, ethanol is accompanied by irritation in the oral cavity, easily causes white lesions in the oral mucosa, affects the alcohol test concentration, and is not suitable for oral disinfection after an outbreak of food.

In addition, in the case of non-alcoholic mouth washes, the emulsion is easily disintegrated, which affects the appearance stability of the mouth wash and the usability of the mouth wash.

The tea tree essential oil has the effects of sterilizing, diminishing inflammation, removing oral odor, preventing tooth decay and keeping fresh breath.

Therefore, in view of the above problems, there is a need for a non-alcoholic tea tree essential oil-containing liquid oral composition which can clean the oral cavity and teeth, promote fresh breath, care gums, maintain a good microenvironment in the oral cavity, and has excellent appearance stability and usability.

Disclosure of Invention

The invention provides a liquid oral composition containing traditional Chinese medicine active substances and tea tree essential oil, which comprises the following components in parts by weight:

wherein the Chinese medicinal extract comprises green tea extract, herba Gnaphalii affinis extract, herba plantaginis extract, herba Lamii Barbati extract, tea tree root extract, Galla chinensis, flos Lonicerae and pericarpium Citri Junoris mixed extract, and violet extract; the additives include wetting agents, pH regulators, preservatives, fragrances and flocculants.

In one embodiment, the herbal extracts further comprise peppermint extract, stevia extract, pansy extract, caraway extract.

In one embodiment, the humectant comprises one or more of sorbitol, xylitol, maltitol, lactitol, ethylene glycol.

In one embodiment, the pH adjusting agent comprises one or more of phthalic acid, phosphoric acid, citric acid, succinic acid, acetic acid, fumaric acid, malic acid, carbonic acid, sodium dihydrogen phosphate, sodium monohydrogen phosphate, sodium citrate.

In one embodiment, the preservative comprises one or more of sodium benzoate, methyl paraben, ethyl paraben, propyl paraben, butyl paraben, and other parabens, glycine alkyl diamino ethyl ester hydrochloride, potassium sorbate, propolis.

In one embodiment, the essence comprises one or more of spearmint oil, eucalyptus oil, wintergreen oil, clove oil, thyme oil, sage oil, cardamom oil, rosemary oil, marjoram oil, lemon oil, nutmeg oil, lavender oil, geranium oil, L-carvone, 1, 8-cineole, methyl salicylate, eugenol, thymol, linalool, limonene, menthone, menthyl acetate, citral, camphor, borneol, pinene, spilanthol.

In one embodiment, the flocculant is modified calcium chloride, and the modified calcium chloride is acrylic acid coated calcium chloride and then grafted chitosan.

In one embodiment, the modified calcium chloride has a grafting ratio of 1 to 5%.

In one embodiment, the modified calcium chloride has a grafting ratio of 1 to 3%.

In another aspect of the present invention, there is provided a method for preparing a liquid oral composition containing a Chinese medicinal active substance and tea tree essential oil, comprising the steps of:

(1) adding the traditional Chinese medicine extract, menthol, tea tree essential oil and water according to the weight part, and stirring to dissolve the traditional Chinese medicine extract in the water;

(2) adding additives according to the weight parts, fully stirring, filtering, taking filtrate, and performing sterilization treatment to obtain the liquid oral composition containing the traditional Chinese medicine active substances and the tea tree essential oil.

The above-described and other features, aspects, and advantages of the present application will become more apparent with reference to the following detailed description.

Detailed Description

The disclosure may be understood more readily by reference to the following detailed description of preferred embodiments of the invention and the examples included therein. Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. In case of conflict, the present specification, including definitions, will control.

The term "prepared from …" as used herein is synonymous with "comprising". The terms "comprises," "comprising," "includes," "including," "has," "having," "contains," "containing," or any other variation thereof, as used herein, are intended to cover a non-exclusive inclusion. For example, a composition, process, method, article, or apparatus that comprises a list of elements is not necessarily limited to only those elements but may include other elements not expressly listed or inherent to such composition, process, method, article, or apparatus.

The conjunction "consisting of …" excludes any unspecified elements, steps or components. If used in a claim, the phrase is intended to claim as closed, meaning that it does not contain materials other than those described, except for the conventional impurities associated therewith. When the phrase "consisting of …" appears in a clause of the subject matter of the claims rather than immediately after the subject matter, it defines only the elements described in the clause; other elements are not excluded from the claims as a whole.

When an amount, volume fraction, or other value or parameter is expressed as a range, preferred range, or as a range of upper preferable values and lower preferable values, this is to be understood as specifically disclosing all ranges formed from any pair of any upper range limit or preferred value and any lower range limit or preferred value, regardless of whether ranges are separately disclosed. For example, when a range of "1 to 5" is disclosed, the described range should be interpreted to include the ranges "1 to 4", "1 to 3", "1 to 2 and 4 to 5", "1 to 3 and 5", and the like. When a range of values is described herein, unless otherwise stated, the range is intended to include the endpoints thereof and all integers and fractions within the range.

The singular forms "a", "an" and "the" include plural referents unless the context clearly dictates otherwise. "optional" or "any" means that the subsequently described event or events may or may not occur, and that the description includes instances where the event occurs and instances where it does not.

Approximating language, as used herein throughout the specification and claims, is intended to modify a quantity, such that the invention is not limited to the specific quantity, but includes portions that are literally received for modification without substantial change in the basic function to which the invention is related. Accordingly, the use of "about" to modify a numerical value means that the invention is not limited to the precise value. In some instances, the approximating language may correspond to the precision of an instrument for measuring the value. In the present description and claims, range limitations may be combined and/or interchanged, including all sub-ranges contained therein if not otherwise stated.

In addition, the indefinite articles "a" and "an" preceding an element or component of the invention are not intended to limit the number requirement (i.e., the number of occurrences) of the element or component. Thus, "a" or "an" should be read to include one or at least one, and the singular form of an element or component also includes the plural unless the stated number clearly indicates that the singular form is intended.

"blend" means a polymer formed by two or more polymers being mixed together by physical or chemical means.

In one embodiment, the traditional Chinese medicine extract comprises, by weight, 1-2 parts of green tea extract, 0.1-1 part of affine cudweed extract, 0.1-1 part of plantain extract, 0.5-1.5 parts of sesameseed extract, 0.1-1.0 part of tea tree root extract, 0.5-3 parts of mixed extract of Chinese gall, honeysuckle and orange peel, 0.01-0.1 part of violet extract, 0.1-1.2 parts of mint extract, 0.05-1.0 part of sweet stevia extract, 0.003-0.2 part of trichrome extract and 0.005-0.3 part of caraway extract.

In one embodiment, the wetting agent is 1-5 parts, the pH regulator is 0.1-0.3 part, the preservative is 0.01-0.1 part, the essence is 0.001-0.1 part, and the flocculating agent is 0.01-0.15 part by weight.

Green tea

The green tea is prepared by fermenting, retains natural substances of fresh leaves, and contains more nutrients such as tea polyphenols, catechin, chlorophyll, caffeine, amino acids, vitamins, etc. The natural nutrient components in the green tea have special effects of preventing aging, cancer, resisting cancer, sterilizing, diminishing inflammation and the like. The green tea is prepared from tea shoots as raw materials by typical processes of de-enzyming, rolling, drying and the like.

Gnaphalium affine

Alias: daylily, cudweed herb, wormwood, veronicastrum herb, gerbera dioica [ Guangdong ], distiller's yeast velvet, white fungus, cudweed herb, citronella, herba et Gemma Agrimoniae, Artemisia annua, downy wormwood, rice koji, hirsute herb, cotton catnip, Mikania sinensis, Japanese milkwort herb, Japanese inula herb, herba inulae, rhizoma anemones Flagelliformis, sowthistle herb, Qingmingxiang, tophyllum odoratum, cotton cauliflower, spinach herb, cotton cocoons, Tinospora capillaris, cudweed herb, Japanese bluegrass herb, Japanese mugwort, tarragon, white mugwort, water yeast, chorionic villous grass, silk cotton grass, hiraute rocky wormwood herb, ternate buttercup herb, Chinese trumpet fern herb, catfoot herb, floret buddleja herb, hairy mugwort, yellow day lily, glutinous rice green, cotton herb, white mango and grass. The whole herb contains 5% of flavonoid glycoside, 0.05% of volatile oil, trace alkaloids and sterols, 0.58% of non-perfoliate, and vitamin B, carrot, chlorophyll, resin, fat, etc. Flower containing luteolin-4-beta-D-glucoside (luteline-4-beta-D-glucoside)

Nature, flavor and meridian tropism: sweet and neutral.

The functional indications are as follows: relieve cough and asthma, lower blood pressure, dispel wind-damp. Can be used for treating common cold with cough, bronchitis, asthma, hypertension, fava bean disease, rheumatism, lumbago, and skelalgia; it is used externally to treat traumatic injury and venomous snake bite.

Plantago asiatica

The whole plant contains plantaginide (Plantago sativa L), aucubin (Aucnbin), ursolic acid (Uralicacid), B-sitosterol, n-hentriacontane, B-sitosterol palmitate, stigmasterol palmitate, vitamin B, vitamin C, and plantaginide (plantaglusid) (which is composed of D-methyl galacturonate, D-galactose, L-arabinose, L-rhamnose, etc.). Protein, succinic acid, adenine, choline, catalpol, stearic acid, arachidic acid, linolenic acid, and linoleic acid.

The nature, taste and function: sweet and cold in nature, entering the hand-Taiyang meridians and yangming meridians. Inducing diuresis, clearing heat, improving eyesight, eliminating phlegm, and can be used for treating dysuria, stranguria with turbid urine, leukorrhagia, hematuria, jaundice, edema, dysentery with diarrhea, epistaxis, conjunctival congestion, swelling and pain, laryngalgia, cough, and skin ulcer.

All-grass of dwarf sessile wildweed

The wild sesame seed (Laium album) is a plant species of the genus Lamiaceae and genus Laminaria. The young leaves are edible, the flowers can be used as medicine, and the whole herb contains saponin, tannin, caffeic acid and various amino acids.

The nature, taste and function: sweet, bitter and cool. Enter liver, kidney and bladder meridians. Promoting blood circulation, removing blood stasis, relieving swelling and pain.

Root of tea tree

The fresh root contains saccharide such as stachyose, raffinose, sucrose, glucose, fructose, etc., and small amount of polyphenol compounds (flavanol, etc.).

The nature, taste and function: bitter; and (6) cooling. Entering the heart; the kidney channel. Strengthening heart and promoting urination; promoting blood circulation to regulate menstruation; clearing away heat and toxic material. Heart disease; edema; hepatitis; dysmenorrhea; sores and ulcers with pyogenic infections; aphtha; burn due to hot soup and fire; herpes zoster; psoriasis vulgaris.

Galla chinensis

The Galla chinensis angle is rhombic or oval, has irregular angular branches, and has a length of 3-8 cm and a diameter of 2-5 cm. The surface is yellow or light yellow brown, and the gray color is soft and smooth, and the short villus is more obvious. Hard and brittle, broken and hollow, with thin wall of about 0.1-0.2 cm, cutin, and most black and brown aphid corpses and gray powder excrement. The inner wall was light brown and smooth. And cutting off cutin. Slightly peculiar odor and astringent taste.

Medicine property: sour, astringent and cold. It enters lung, large intestine and kidney meridians.

The efficacy is as follows: astringe lung to reduce fire, relieve cough and stop sweating, check diarrhea with astringents, secure essence and check nocturnal emission, astringe to stop bleeding, astringe dampness and heal wound.

The main treatment is as follows: cough, hemoptysis, spontaneous perspiration, night sweat, chronic diarrhea, chronic dysentery, spermatorrhea, metrorrhagia, hematochezia, hemorrhoid, eczema, and toxic swelling.

Honeysuckle flower

Honeysuckle, also known as honeysuckle, honeysuckle flower, etc., has been known as a good medicine for clearing heat and removing toxicity since ancient times. It is sweet and cold in nature and fragrant, sweet and cold in nature and clearing heat without hurting stomach, and the fragrance is thorough and can eliminate pathogens. Honeysuckle can disperse wind-heat and clear blood toxin, and has obvious effect on various heat diseases such as fever, eruption, macula, sore and carbuncle due to heat toxin, sore throat and the like. According to the 2005 edition of the Chinese pharmacopoeia, Lonicera japonica is a dried bud or a flower with an initial bloom of Lonicera japonica (Lonicera japonica Thunb) belonging to the genus Lonicera of the family Caprifoliaceae.

The honeysuckle has broad-spectrum antibacterial effect and has stronger inhibition effect on pathogenic bacteria such as staphylococcus aureus, dysentery bacillus and the like; has obvious anti-inflammatory and antipyretic effects; the water and wine soaking solution of flos Lonicerae has obvious cytotoxic effect on sarcoma 180 and Ehrlich ascites tumor, and also has certain cholesterol lowering effect.

Nature, flavor and meridian tropism: sweet and cold in nature. It enters lung, heart and stomach meridians.

The efficacy application is as follows: clear heat and remove toxicity, disperse wind-heat. It can be used for treating carbuncle, furunculosis, red swelling, pain, wind-heat, warm disease, dysentery, summer heat, polydipsia, and sore throat.

Violet is a new type

Violet, latin literature name: (Matthiola incana (L.) R.Br.) Cruciferae, Viola genus biennial or perennial herbs. The whole plant is densely covered by offwhite branches with stems. The stem is upright, multi-branched, and slightly lignified at the base. The long round shape of the leaf blade is the shape of a reversed scalded needle or a spoon.

Violet has the effects of clearing heat and removing toxicity, whitening and removing freckles, moistening skin, removing wrinkles and freckles, removing peculiar smell in the oral cavity, enhancing gloss and preventing ultraviolet irradiation, has great help to respiratory tracts, has the effect of conditioning bronchitis, can moisten throat and solves the peculiar smell in the oral cavity caused by decayed teeth.

Mint

The mint, named as "Yindancao" is a labiate plant, i.e., other dry whole herbs of the same genus, mostly grows beside the mountain wetland, with roots and stems transversely growing underground. The whole plant is green and fragrant. The leaves are in pairs, the flowers are small and light purple, the lips are shaped, and dark purple brown small-grain fruits are formed after the flowers are bloomed.

The herba Menthae has special fragrance, pungent taste and cool feeling, and can be used in medicine for dispelling pathogenic wind, preventing corrosion, relieving inflammation, relieving pain, relieving itching, invigorating stomach, etc. The whole herb is pungent and cool. It enters lung and liver meridian, has effects of dispelling pathogenic wind heat, clearing and removing heat from throat, promoting eruption, removing toxic substance, dispersing stagnated liver qi, relieving qi stagnation and itching etc., is suitable for common cold with fever, headache, sore throat, anhidrosis, wind fire with red eyes, rubella, skin itch, hernia pain, dysentery and lymphoid tuberculosis etc., and has slight analgesic effect for external use, and is used for neuralgia etc.

Stevia rebaudiana (Bertoni) Hemsl

The leaf contains stevioside, steviolbioside, stevioside A, stevioside B, dulcoside A, dulcoside B, dulcoside C, D, E, dulcoside A, 6-O-acetyl eupatorin, eupatiol, and eupatorin.

Nature, flavor and meridian tropism: sweet and cold; it enters lung and stomach meridians.

The efficacy and the effect are as follows: promoting the production of body fluid to quench thirst; reducing blood pressure. Diabetes mainly; hypertension.

Orange peel

The pericarpium Citri Junoris is pericarp of Citrus sinensis of Rutaceae. The sweet orange evergreen small arbor is cultivated on hills, low mountain areas, along banks of rivers and lakes, and is cultivated in every part of the south of the Yangtze river in China, and the variety is large. In winter or in the beginning of spring, the peeled pericarp is dried in the sun or baked.

Nature, flavor and meridian tropism: warm in nature, sweet and bitter in taste and non-toxic; enter spleen and lung meridians.

The efficacy and the effect are as follows: regulate qi, resolve phlegm, invigorate spleen and remove stagnancy. It is used to treat common cold, cough, anorexia, abdominal distention, borborygmus, diarrhea, and acute mastitis.

Viola tricolor

Viola tricolor L is an annual or short-lived perennial herb of Viola of the family Violaceae. The stem and leaf contain pansy glycoside; the flower contains rutin, volatile oil, saponin, and vitamin A, C. The pansy can kill bacteria and treat acne and allergy on skin. The Shenqi pox-removing efficacy of pansy is carried in detail in the shengdian of traditional Chinese medicine (compendium of materia Medica): pansy, mild in nature and superficial temperature, fragrant in flavor, can be used to guide herbs to go upward to the surface to remove sores and scars and relieve swelling of sores and ulcers. The pansy whole plant can be used as a medicine, and stem leaves contain pansy, so that the pansy whole plant is mainly used for treating diseases such as cough and the like.

Nature, flavor and meridian tropism: cold and bitter; meridian tropism and lung meridian tropism.

The efficacy and the effect are as follows: clearing away heat and toxic materials; relieving cough. Treating pyocutaneous disease with pyogenic infections; infantile eczema; scrofula of children; and (5) cough.

Carum carvi

Carum carvi is the fruit of the plant Artemisia annua of Umbelliferae. The fruit contains volatile oil 3.5-7% of caraway oil, and the oil contains main components of d-carvone 50-60% and d-limonene.

Nature, flavor and meridian tropism: warm in nature, sweet and pungent in flavor; enter kidney and stomach meridians.

The efficacy and the effect are as follows: fragrant, invigorating stomach, expelling wind and regulating qi. It is indicated for stomach ache, abdominal pain and hernia of small intestine.

The extraction method of the green tea extract comprises the following steps:

tea polysaccharide: 20g of the pulverized tea sample is taken, and the mixture is mixed with distilled water preheated to 55 ℃ in a ratio of 1: extracting at a ratio of 20(w/v) in a water bath at 55 deg.C for 2.5h under stirring, filtering, centrifuging at 4000r/min for 15min, collecting supernatant, concentrating, precipitating with 3 times volume of 95% ethanol, centrifuging to obtain tea polysaccharide precipitate, and freeze drying to obtain tea polysaccharide.

Tea polyphenol: 20g of the pulverized tea sample is taken, and the mixture is mixed with distilled water preheated to 55 ℃ in a ratio of 1: extracting with 20(w/V) water bath at 55 deg.C under stirring for 2.5h, filtering, centrifuging at 400Or/min for 15min, collecting supernatant, concentrating, and extracting with A1³⁺Precipitating tea polyphenols in pH5.3-5.7 environment, dissolving tea polyphenols-aluminum precipitate, extracting with ethyl acetate for 3 times, and vacuum freeze drying to obtain tea polyphenols (I); and taking a proper amount of supernatant, concentrating, extracting for 3 times by using ethyl acetate with the same volume, and carrying out vacuum freeze drying to obtain the tea polyphenol (II).

The extraction method of the affine cudweed extract comprises the following steps:

weighing 20.0g of affine cudweed, drying, crushing, adding ethanol with the mass concentration of 70% -80%, soaking for 2-3 h, extracting for 2-3 times by microwave heating, filtering, and concentrating the filtrate under reduced pressure until no ethanol exists, thus obtaining the affine cudweed.

The extraction method of the plantain herb extract comprises the following steps:

weighing 20.0g of plantain, drying, crushing, adding 80-90% ethanol by mass concentration, soaking for 2-3 h, extracting for 2-3 times by microwave heating, filtering, and concentrating the filtrate under reduced pressure until no ethanol exists, thus obtaining the plantain extract.

The extraction method of the sesameia brachypodium extract comprises the following steps:

cleaning and chopping the short-stalk wild sesame flower, adding a citric acid aqueous solution with the mass concentration of 3-5 g/L, soaking for 2-3 h, extracting for 2-3 times by microwave heating, filtering, and drying the filtrate under reduced pressure to obtain the wild sesame flower.

The extraction method of the tea tree root extract comprises the following steps:

weighing 20.0g of tea tree root, cleaning, drying, crushing, adding 75-85% ethanol by mass concentration, soaking for 2-3 h, extracting for 2-3 times by microwave heating, filtering, and concentrating the filtrate under reduced pressure until no ethanol exists, thus obtaining the tea tree root extract.

The extraction method of the violet extract comprises the following steps:

weighing 20.0g of dried violet, crushing, adding into hot water at 100 ℃, soaking for 1h, then adding ethanol with the concentration of 80-85%, heating and extracting for 1-3 times by using microwave with the microwave power of 80-100W, filtering, and concentrating the filtrate under reduced pressure until no ethanol exists, thus obtaining the violet-tea beverage.

The extraction method of the mint extract comprises the following steps:

pulverizing herba Menthae into coarse powder, and placing in supercritical CO₂An extraction device, under the conditions of 6MPa of analytic pressure, 35 ℃ of analytic temperature, 3.0h of extraction time, 45 ℃ of extraction temperature, 35MPa of extraction pressure and CO₂The flow rate is 40kg/h to obtain the mint extract.

The extraction method of the stevia rebaudiana extract comprises the following steps:

pulverizing sweet stevia into coarse powder, and placing in supercritical CO₂An extraction device, under the conditions of 6MPa of analytic pressure, 40 ℃ of analytic temperature, 3.0h of extraction time, 55 ℃ of extraction temperature, 40MPa of extraction pressure and CO₂The flow rate is 50kg/h to obtain stevia extract.

The extraction method of the mixed extract of the Chinese gall, the honeysuckle and the orange peel comprises the following steps:

mixing Galla chinensis, flos Lonicerae and pericarpium Citri Junoris at a weight ratio, blasting and pulverizing to 100-mesh 200 meshes, mixing with 0.1 weight part of 2-mercaptobenzothiazole, extracting with ethanol as solvent, refluxing for 2h, filtering while hot, and concentrating until no ethanol is present.

In one embodiment, the weight ratio of the gallnut to the honeysuckle and the orange peel is 1: 0.3: 0.2.

the extraction method of the pansy extract comprises the following steps:

weighing 20.0g of dried pansy, crushing, adding into hot water of 90 ℃, soaking for 2h, then adding 75-85% ethanol, heating and extracting for 1-3 times by using microwave with the microwave power of 80-100W, filtering, and concentrating the filtrate under reduced pressure until no ethanol exists, thus obtaining the pansy.

The extraction method of the Carum carvi extract comprises the following steps:

weighing 20.0g of dried caraway, crushing, adding into hot water of 100 ℃, soaking for 2h, then adding ethanol with the concentration of 95%, heating and extracting for 1-3 times by using microwave with the microwave power of 80-100W, filtering, and concentrating the filtrate under reduced pressure until no ethanol exists, thus obtaining the caraway.

Tea tree essential oil

Tea tree essential oil is native to Australia and is an extract of tea tree. Has antibacterial, antiinflammatory, pore astringing, common cold, cough, rhinitis, asthma treating, dysmenorrhea improving, menoxenia and genital infection relieving effects. It is suitable for oily and acne skin, and can be used for treating suppurative wound, burn, sunburn, tinea pedis, and dandruff. Refreshing brain, restoring vitality and resisting depression.

The most important chemical components are p-menthene (terpinene), terpineol (pinene), limonene (limone), cineol (cineole), terpineol (terpineol) and anisic acid (cumene).

The extraction method takes the leaves and the tender tips as raw materials, adopts a steam distillation method for extraction, and has the oil yield of 1.8 percent.

pH regulator

A pH adjuster, also called a pH adjuster, an acidity adjuster or a pH controller, etc., is used as a food additive for adjusting or maintaining the pH (acid or alkali). The acidity regulator may be an organic or inorganic acid, a base, a neutralizing agent or a buffer.

Acidity regulators have many functional properties that enhance the quality of food products, such as altering and maintaining the acidity and improving the flavor of food products; improving antioxidant effect, and preventing food spoilage; complexing with heavy metal ions, the product has the effects of preventing oxidation or browning reaction, stabilizing color, reducing turbidity, enhancing gelation property, etc.

In one embodiment, the pH adjusting agent comprises one or more of phthalic acid, phosphoric acid, citric acid, succinic acid, acetic acid, fumaric acid, malic acid, carbonic acid, sodium dihydrogen phosphate, sodium monohydrogen phosphate, sodium citrate; preferably, the pH regulator is citric acid or sodium citrate.

In one embodiment, the weight ratio of the citric acid to the sodium citrate is 1: 0.8.

preservative

The preservative is a food additive which is a natural or synthetic chemical component and is used for keeping the original quality and the nutritional value of food. The preservative mainly acts as an agent for inhibiting the growth and reproduction of microorganisms, so as to prolong the storage time of food and inhibit the putrefaction of substances. The food preservative can inhibit the activity of microorganisms and prevent the food from being rotten, thereby prolonging the shelf life of the food.

In one embodiment, the preservative comprises one or more of sodium benzoate, methyl paraben, ethyl paraben, propyl paraben, butyl paraben and other parabens, glycine alkyl diamino ethyl ester hydrochloride, potassium sorbate, propolis; preferably, the preservative is propolis.

Essence

The essence is a concentrated aromatic oil which is synthesized by people and imitates the smell of fruits and natural spices.

In one embodiment, the essence comprises one or more of spearmint oil, eucalyptus oil, wintergreen oil, clove oil, thyme oil, sage oil, cardamom oil, rosemary oil, marjoram oil, lemon oil, nutmeg oil, lavender oil, geranium oil, L-carvone, 1, 8-cineole, methyl salicylate, eugenol, thymol, linalool, limonene, menthone, menthyl acetate, citral, camphor, borneol, pinene, spilanthol; preferably, the essence comprises one or more of spearmint oil, eucalyptus oil, wintergreen oil, clove oil, thyme oil, sage oil, cardamom oil, rosemary oil, marjoram oil, lemon oil, nutmeg oil, lavender oil, osbeckia oil, limonene; more preferably, the essence is one or more of lemon oil and limonene.

In one embodiment, the modified calcium chloride is prepared as follows:

(1) adding calcium chloride into a high-speed mixer with a charging basket at 50 ℃, adding acrylic acid according to the weight ratio, stirring for 0.5-2 h, discharging, raising the temperature of the charging basket of the high-speed mixer to 120 ℃, pouring the materials into the high-speed mixer, stirring at high speed for 0.5-1 h, and discharging to obtain acrylic acid coated calcium chloride; the weight ratio of the acrylic acid to the calcium chloride is 1: (10-20);

(2) fully dissolving chitosan in water to prepare an aqueous solution with the chitosan concentration of 0.02mol/L, adding the calcium chloride acrylate and the polyphosphoric acid in the step (1) into the aqueous solution of chitosan, reacting for 10-20 h at 50-80 ℃, dialyzing and freeze-drying to obtain modified calcium chloride; the weight ratio of the calcium chloride acrylate to the polyphosphoric acid is 1: (8-15).

According to the invention, the antibacterial effect of the liquid oral composition is improved and the stability of the liquid oral composition is maintained by modifying calcium chloride, so that the layering of substances is avoided.

In the invention, the solubility of the modified calcium chloride in water is 0.5g at the temperature of 15-30 ℃.

According to the invention, the acrylic acid AA has high reaction activity, one end of the acrylic acid AA is a strongly acidic carboxyl group and can be bonded with the surface of calcium chloride, the acrylic acid is combined on the surface of calcium chloride with a porous structure, chitosan with a good antibacterial effect is subjected to a grafting reaction with the acrylic acid calcium chloride, and the surface of the obtained modified calcium chloride is covered with polar groups of organic matters containing carboxyl, hydroxyl, amino and the like, so that the modified calcium chloride has surface oleophylic and hydrophilic groups, the stability of the liquid oral composition can be well improved, and the antibacterial effect is also good.

In one embodiment, the sterilization process is instantaneous sterilization using high temperature.

High temperature instantaneous sterilization

The high-temperature instantaneous sterilization refers to a process of rapidly achieving the culture medium temperature of 130-140 ℃ by using saturated steam under a heating condition, maintaining for several minutes, and then rapidly cooling to the culture temperature to complete sterilization. Its advantages are high effect on killing the heat-resistant spores of microbes, less damage to nutrients and high utilization rate of raw materials.

The green tea extract, the affine cudweed extract, the sesamum brachypodium extract, the tea tree root extract, the Chinese gall extract, the honeysuckle extract and the mint extract can clear breath, sterilize and diminish inflammation; the violet extract, the stevia extract, the orange peel extract, the pansy extract and the caraway extract are used for regulating the mouthfeel.

The liquid oral composition containing the traditional Chinese medicine extract has excellent taste, relieves the oral discomfort symptom, keeps good micro-ecology, and has the effects of diminishing inflammation and relieving pain; the invention avoids white lesions of oral mucosa caused by alcohol easily, and avoids the influence of mouth on alcohol test concentration by using the liquid oral composition, and is particularly suitable for oral disinfection after foreign gathering.

The present invention will be specifically described below by way of examples. It should be noted that the following examples are only for illustrating the present invention and should not be construed as limiting the scope of the present invention, and that the insubstantial modifications and adaptations of the present invention by those skilled in the art based on the above disclosure are still within the scope of the present invention.

In addition, the raw materials used are commercially available from national chemical reagents, unless otherwise specified.

Example 1

The preparation method of the liquid oral composition containing the traditional Chinese medicine active substances and the tea tree essential oil comprises the following steps:

The liquid oral composition containing the traditional Chinese medicine active substances and the tea tree essential oil comprises the following components in parts by weight: 1.6 parts of green tea extract, 0.7 part of affine cudweed extract, 0.5 part of plantain extract, 1.0 part of sesameseed extract, 0.6 part of tea tree root extract, 2.3 parts of gallnut, honeysuckle and orange peel mixed extract, 0.02 part of violet extract, 0.35 part of mint extract, 0.12 part of stevia extract, 0.005 part of pansy extract and 0.007 part of caraway extract, 3.1 parts of xylitol, 0.15 part of citric acid and sodium citrate, 0.05 part of propolis, 0.003 part of limonene and lemon oil and 0.06 part of modified calcium chloride, 0.002 part of menthol, 0.003 part of tea tree essential oil and 92 parts of water; the weight ratio of the gallnut to the honeysuckle and the orange peel is 1: 0.3: 0.2; the weight ratio of the citric acid to the sodium citrate is 1: 0.8; the weight ratio of the limonene to the lemon oil is 1: 0.6.

the preparation method of the modified calcium chloride comprises the following steps:

(1) adding calcium chloride into a high-speed mixer with a charging basket at 50 ℃, adding acrylic acid according to the weight ratio, stirring for 1h, discharging, heating the charging basket of the high-speed mixer to 120 ℃, pouring the materials into the high-speed mixer, stirring at high speed for 1h, and discharging to obtain acrylic acid coated calcium chloride; the weight ratio of the acrylic acid to the calcium chloride is 1: 13;

(2) fully dissolving chitosan in water to prepare an aqueous solution with the chitosan concentration of 0.02mol/L, adding the calcium chloride acrylate and the polyphosphoric acid in the step (1) into the aqueous solution of chitosan, reacting for 18h at 60 ℃, dialyzing and freeze-drying to obtain modified calcium chloride; the weight ratio of the calcium chloride acrylate to the polyphosphoric acid is 1: 10.

example 2

The liquid oral composition containing the traditional Chinese medicine active substances and the tea tree essential oil comprises the following components in parts by weight: 2 parts of green tea extract, 0.1 part of affine cudweed extract, 0.1 part of plantain extract, 0.5 part of sesameseed extract, 0.1 part of tea tree root extract, 3 parts of gallnut, honeysuckle and orange peel mixed extract, 0.02 part of violet extract, 1 part of mint extract, 0.12 part of stevia rebaudiana extract, 0.003 part of pansy extract and 0.1 part of caraway extract, 3.1 parts of xylitol, 0.15 part of citric acid and sodium citrate, 0.05 part of propolis, 0.003 part of limonene and lemon oil, 0.06 part of modified calcium chloride, 0.002 part of menthol, 0.003 part of tea tree essential oil and 92 parts of water; the weight ratio of the gallnut to the honeysuckle and the orange peel is 1: 0.3: 0.2; the weight ratio of the citric acid to the sodium citrate is 1: 0.8; the weight ratio of the limonene to the lemon oil is 1: 0.6.

the preparation method of the liquid oral composition containing the traditional Chinese medicine active substances and the tea tree essential oil and the preparation method of the modified calcium chloride are the same as those in example 1.

Example 3

The liquid oral composition containing the traditional Chinese medicine active substances and the tea tree essential oil comprises the following components in parts by weight: 2 parts of green tea extract, 1 part of affine cudweed extract, 1 part of plantain extract, 1.5 parts of sessile sesameseed extract, 0.6 part of tea tree root extract, 0.5 part of Chinese gall, honeysuckle and orange peel mixed extract, 0.05 part of violet extract, 0.1 part of mint extract, 0.12 part of stevia rebaudiana extract, 0.005 part of pansy extract and 0.007 part of caraway extract, 3.1 parts of xylitol, 0.15 part of citric acid and sodium citrate, 0.05 part of propolis, 0.003 part of limonene and lemon oil, 0.06 part of modified calcium chloride, 0.002 part of menthol, 0.003 part of tea tree essential oil and 92 parts of water; the weight ratio of the gallnut to the honeysuckle and the orange peel is 1: 0.3: 0.2; the weight ratio of the citric acid to the sodium citrate is 1: 0.8; the weight ratio of the limonene to the lemon oil is 1: 0.6.

Example 4

The liquid oral composition containing the traditional Chinese medicine active substances and the tea tree essential oil comprises the following components in parts by weight: 1.6 parts of green tea extract, 0.7 part of affine cudweed extract, 0.5 part of plantain extract, 1.0 part of sesameseed extract, 0.6 part of tea tree root extract, 2.3 parts of honeysuckle extract, 0.02 part of violet extract, 0.35 part of mint extract, 0.12 part of stevia rebaudiana extract, 0.003 part of pansy extract and 0.007 part of caraway extract, 3.1 parts of xylitol, 0.15 part of citric acid and sodium citrate, 0.05 part of propolis, 0.003 part of limonene and lemon oil, 0.06 part of modified calcium chloride, 0.002 part of menthol, 0.003 part of tea tree essential oil and 92 parts of water; the weight ratio of the citric acid to the sodium citrate is 1: 0.8; the weight ratio of the limonene to the lemon oil is 1: 0.6.

the extraction method of the honeysuckle extract comprises the following steps:

weighing 20.0g of honeysuckle, drying, crushing, adding ethanol with the mass concentration of 85% -95%, soaking for 2-3 h, extracting for 2-3 times by microwave heating, filtering, and concentrating the filtrate under reduced pressure until no ethanol exists, thus obtaining the honeysuckle tea.

Example 5

The liquid oral composition containing the traditional Chinese medicine active substances and the tea tree essential oil comprises the following components in parts by weight: 1.6 parts of green tea extract, 0.7 part of affine cudweed extract, 0.5 part of plantain extract, 1.0 part of sesameseed extract, 0.6 part of tea tree root extract, 2.3 parts of Chinese gall extract, 0.02 part of violet extract, 0.35 part of mint extract, 0.12 part of stevia rebaudiana extract, 0.003 part of pansy extract and 0.007 part of caraway extract, 3.1 parts of xylitol, 0.15 part of citric acid and sodium citrate, 0.05 part of propolis, 0.003 part of limonene and lemon oil, 0.06 part of modified calcium chloride, 0.002 part of menthol, 0.003 part of tea tree essential oil and 92 parts of water; the weight ratio of the citric acid to the sodium citrate is 1: 0.8; the weight ratio of the limonene to the lemon oil is 1: 0.6.

the extraction method of the Chinese gall extract comprises the following steps:

weighing 20.0g of gallnut, cleaning, drying, crushing, adding ethanol with the mass concentration of 70-85%, soaking for 2-3 h, extracting for 2-3 times by microwave heating, filtering, and concentrating the filtrate under reduced pressure until no ethanol exists, thus obtaining the Chinese gall tea.

Example 6

The liquid oral composition containing the traditional Chinese medicine active substances and the tea tree essential oil comprises the following components in parts by weight: 1.6 parts of green tea extract, 0.7 part of affine cudweed extract, 0.5 part of plantain extract, 1.0 part of sesameseed extract, 0.6 part of tea tree root extract, 2.3 parts of orange peel extract, 0.02 part of violet extract, 0.35 part of mint extract, 0.12 part of stevia rebaudiana extract, 0.003 part of pansy extract and 0.007 part of caraway extract, 3.1 parts of xylitol, 0.15 part of citric acid and sodium citrate, 0.05 part of propolis, 0.003 part of limonene and lemon oil, 0.06 part of modified calcium chloride, 0.002 part of menthol, 0.003 part of tea tree essential oil and 92 parts of water; the weight ratio of the citric acid to the sodium citrate is 1: 0.8; the weight ratio of the limonene to the lemon oil is 1: 0.6.

the extraction method of the orange peel extract comprises the following steps:

weighing 20.0g of orange peel, drying, crushing, adding 50-60% ethanol, soaking for 2-3 h, extracting for 2-3 times by microwave heating, filtering, and concentrating the filtrate under reduced pressure until no ethanol exists, thus obtaining the orange peel tea.

Example 7

The liquid oral composition containing the traditional Chinese medicine active substances and the tea tree essential oil comprises the following components in parts by weight: 0.7 part of affine cudweed extract, 0.5 part of plantain herb extract, 1.0 part of sesameseed extract, 2.3 parts of gallnut, honeysuckle and orange peel mixed extract, 0.02 part of violet extract, 0.35 part of mint extract, 0.12 part of stevia extract, 0.003 part of pansy extract, 0.007 part of caraway extract, 3.1 parts of xylitol, 0.15 part of citric acid, 0.05 part of propolis, 0.003 part of lemon oil and 0.06 part of modified calcium chloride, 0.002 part of menthol, 0.003 part of tea tree essential oil and 92 parts of water; the weight ratio of the gallnut to the honeysuckle and the orange peel is 1: 0.3: 0.2.

Example 8

The liquid oral composition containing the traditional Chinese medicine active substances and the tea tree essential oil comprises the following components in parts by weight: 1.6 parts of green tea extract, 0.7 part of affine cudweed extract, 0.5 part of plantain extract, 1.0 part of sesameseed extract, 0.6 part of tea tree root extract, 2.3 parts of gallnut, honeysuckle and orange peel mixed extract, 0.02 part of violet extract, 0.35 part of mint extract, 0.12 part of stevia extract, 0.005 part of pansy extract and 0.007 part of caraway extract, 3.1 parts of xylitol, 0.15 part of citric acid and sodium citrate, 0.05 part of propolis, 0.003 part of limonene and lemon oil and 0.01 part of modified calcium chloride, 0.002 part of menthol, 0.003 part of tea tree essential oil and 92 parts of water; the weight ratio of the gallnut to the honeysuckle and the orange peel is 1: 0.3: 0.2; the weight ratio of the citric acid to the sodium citrate is 1: 0.8; the weight ratio of the limonene to the lemon oil is 1: 0.6.

Example 9

The liquid oral composition containing the traditional Chinese medicine active substances and the tea tree essential oil comprises the following components in parts by weight: 1.6 parts of green tea extract, 0.7 part of affine cudweed extract, 0.5 part of plantain extract, 1.0 part of sesameseed extract, 0.6 part of tea tree root extract, 2.3 parts of gallnut, honeysuckle and orange peel mixed extract, 0.02 part of violet extract, 0.35 part of mint extract, 0.12 part of stevia extract, 0.005 part of pansy extract and 0.007 part of caraway extract, 3.1 parts of xylitol, 0.15 part of citric acid and sodium citrate, 0.05 part of propolis, 0.003 part of limonene and lemon oil and 0.15 part of modified calcium chloride, 0.002 part of menthol, 0.003 part of tea tree essential oil and 92 parts of water; the weight ratio of the gallnut to the honeysuckle and the orange peel is 1: 0.3: 0.2; the weight ratio of the citric acid to the sodium citrate is 1: 0.8; the weight ratio of the limonene to the lemon oil is 1: 0.6.

Comparative example 1

The liquid oral composition containing the traditional Chinese medicine active substances and the tea tree essential oil comprises the following components in parts by weight: 1.6 parts of green tea extract, 0.7 part of affine cudweed extract, 0.5 part of plantain extract, 1.0 part of sesameseed extract, 0.6 part of tea tree root extract, 2.3 parts of gallnut, honeysuckle and orange peel mixed extract, 0.02 part of violet extract, 0.35 part of mint extract, 0.12 part of stevia extract, 0.005 part of pansy extract and 0.007 part of caraway extract, 3.1 parts of xylitol, 0.15 part of citric acid and sodium citrate, 0.05 part of propolis, 0.003 part of limonene and lemon oil and 0.06 part of modified calcium chloride, 0.002 part of menthol, 0.003 part of tea tree essential oil and 92 parts of water; the weight ratio of the gallnut to the honeysuckle and the orange peel is 1: 0.3: 0.2; the weight ratio of the citric acid to the sodium citrate is 1: 0.8; the weight ratio of the limonene to the lemon oil is 1: 0.6; the modified calcium chloride is acrylic acid coated calcium chloride.

adding calcium chloride into a high-speed mixer with a charging basket at 50 ℃, adding acrylic acid according to the weight ratio, stirring for 1h, discharging, heating the charging basket of the high-speed mixer to 120 ℃, pouring the materials into the high-speed mixer, stirring at high speed for 1h, and discharging to obtain acrylic acid coated calcium chloride; the weight ratio of the acrylic acid to the calcium chloride is 1: 13.

the preparation method of the liquid oral composition containing the traditional Chinese medicine active substances and the tea tree essential oil is the same as that of example 1.

Comparative example 2

The liquid oral composition containing the traditional Chinese medicine active substances and the tea tree essential oil comprises the following components in parts by weight: 1.6 parts of green tea extract, 0.7 part of affine cudweed extract, 0.5 part of plantain extract, 1.0 part of sesameseed extract, 0.6 part of tea tree root extract, 2.3 parts of gallnut, honeysuckle and orange peel mixed extract, 0.02 part of violet extract, 0.35 part of mint extract, 0.12 part of stevia extract, 0.005 part of pansy extract and 0.007 part of caraway extract, 3.1 parts of xylitol, 0.15 part of citric acid and sodium citrate, 0.05 part of propolis, 0.003 part of limonene and lemon oil, 0.06 part of calcium chloride, 0.002 part of menthol, 0.003 part of tea tree essential oil and 92 parts of water; the weight ratio of the gallnut to the honeysuckle and the orange peel is 1: 0.3: 0.2; the weight ratio of the citric acid to the sodium citrate is 1: 0.8; the weight ratio of the limonene to the lemon oil is 1: 0.6.

Comparative example 3

The liquid oral composition containing the traditional Chinese medicine active substances and the tea tree essential oil comprises the following components in parts by weight: 0.5 part of plantain extract, 2.3 parts of orange peel extract, 0.02 part of violet extract, 0.12 part of stevia rebaudiana extract, 0.005 part of pansy extract and 0.007 part of caraway extract, 3.1 parts of xylitol, 0.15 part of citric acid and sodium citrate, 0.05 part of propolis, 0.003 part of limonene and lemon oil and 0.06 part of modified calcium chloride, 0.002 part of menthol, 0.003 part of tea tree essential oil and 92 parts of water; the weight ratio of the citric acid to the sodium citrate is 1: 0.8; the weight ratio of the limonene to the lemon oil is 1: 0.6.

And (3) performance testing:

1. evaluation of appearance stability:

450ml of the sample liquid oral composition was filled in a PET container filled with 450ml of the full scale, and the stability after 3 months of storage in a thermostatic bath at 50 ℃ or 3 months of storage in a thermostatic bath at-10 ℃ was visually judged. Evaluation criteria for appearance stability (50 ℃ C., 3 months):

well: the color tone of the formulation did not change;

in general: the shade of the formulation faded only slightly but not at a problematic level;

difference: the color tone of the formulation was discolored.

Evaluation criteria for appearance stability (-10 ℃, 3 months):

well: no change;

in general: very little separation can be seen, but at an unproblematic level;

difference: there was separation and fading of the color tone of the preparation.

2. Taste of the product

After rinsing 10ml of a sample (liquid oral composition) for 30 seconds, subjects evaluated the continuation of cooling sensation, the feeling of retained reality, and the feeling of no retained viscosity after rinsing 10 minutes with the preparation, and evaluated the average score of 10 subjects according to the following criteria.

(1) Persistence of cooling sensation

And 5, dividing: persistence of a cool feeling is strongly felt

And 4, dividing: the persistence of the refreshing feeling was strongly felt

And 3, dividing: feeling of persistence of a refreshing feeling

And 2, dividing: persistence of substantially no cooling sensation

1 minute: the persistence of a cooling sensation is not felt;

(2) sense of retention

And 4, dividing: the feeling of remaining mouthwash in the mouth was strongly felt

And 3, dividing: feeling of remaining of mouthwash in mouth

And 2, dividing: substantially no feeling of remaining mouthwash in the mouth

1 minute: the residual sense of the mouthwash in the mouth is not felt;

(3) viscous feeling

And 4, dividing: no sticky feeling

And 3, dividing: basically no sticky feeling is felt

And 2, dividing: feeling of stickiness

1 minute: a sticky feeling is strongly felt.

3. Bacteriostatic activity

In a sterile table, 9ml of each of the liquid oral compositions of examples and comparative examples and physiological saline as a control were added to a sterile glass test tube. Then, 1ml of Escherichia coli bacterial liquid (photometric value (O.D) 0.1, colony count 106CFU/ml) was added to each sterile glass tube and mixed, and then densitometric measurement was performed. And simultaneously taking out the bacterial liquid from each sterile glass test tube, and smearing the diluted bacterial liquid in a solid culture medium for measurement by a coating method. Then each sterile glass test tube and each solid culture medium are placed in a constant temperature incubator at 37 ℃ for culture for 8 hours, and then the light absorption value of each sterile glass test tube after culture and the colony number of each coating plate after culture are measured.

The bacteriostatic activity of the coating method is that the difference between the number of the colonies cultured by the coating of the control group and the number of the colonies cultured by the coating of the experimental group is divided by the number of the colonies cultured by the coating of the control group. And respectively testing escherichia coli, staphylococcus aureus and pseudomonas aeruginosa to obtain the data of the antibacterial activity.

Table 1 results of performance testing

As can be seen from the above test results, the present invention has not only excellent taste, alleviation of oral discomfort symptoms, maintenance of good micro-ecology, but also anti-inflammatory and analgesic effects, as compared with comparative examples of acrylic acid-coated calcium chloride, no green tea extract, gnaphalium affine extract, brevifolium extract, camellia sinensis root extract, gallnut extract, honeysuckle extract, mint extract.

The foregoing examples are merely illustrative and serve to explain some of the features of the method of the present invention. The appended claims are intended to claim as broad a scope as is contemplated, and the examples presented herein are merely illustrative of selected implementations in accordance with all possible combinations of examples. Accordingly, it is applicants' intention that the appended claims are not to be limited by the choice of examples illustrating features of the invention. Also, where numerical ranges are used in the claims, subranges therein are included, and variations in these ranges are also to be construed as possible being covered by the appended claims.

Claims

1. A liquid oral composition containing traditional Chinese medicine active substances and tea tree essential oil is characterized by comprising the following components in parts by weight:

wherein the Chinese medicinal extract comprises green tea extract, herba Gnaphalii affinis extract, herba plantaginis extract, herba Lamii Barbati extract, tea tree root extract, Galla chinensis, flos Lonicerae and pericarpium Citri Junoris mixed extract, and violet extract; the additives comprise wetting agents, pH regulators, preservatives, essences and flocculants;

the Chinese medicinal extract also comprises herba Menthae extract, sweet stevia extract, herba Violae Hortensis extract, and fructus Cari Carvi extract;

the traditional Chinese medicine extract comprises, by weight, 1-2 parts of a green tea extract, 0.1-1 part of a affine cudweed extract, 0.1-1 part of a plantain extract, 0.5-1.5 parts of a sessile sesameseed extract, 0.1-1.0 part of a tea tree root extract, 0.5-3 parts of a mixed extract of gallnut, honeysuckle and orange peel, 0.01-0.1 part of a violet extract, 0.1-1.2 parts of a mint extract, 0.05-1.0 part of a stevia rebaudiana extract, 0.003-0.2 part of a pansy extract and 0.005-0.3 part of a caraway extract;

the flocculant is modified calcium chloride, and the modified calcium chloride is chitosan grafted after calcium chloride is coated by acrylic acid; the grafting rate of the modified calcium chloride is 1-5%;

(1) adding calcium chloride into a high-speed mixer with a charging basket at 50 ℃, adding acrylic acid according to the weight ratio, stirring for 0.5-2 h, discharging, raising the temperature of the charging basket of the high-speed mixer to 120 ℃, pouring the materials into the high-speed mixer, stirring at high speed for 0.5-1 h, and discharging to obtain acrylic acid coated calcium chloride; the weight ratio of the acrylic acid to the calcium chloride is 1: 10-20;

(2) fully dissolving chitosan in water to prepare an aqueous solution with the chitosan concentration of 0.02mol/L, adding the calcium chloride acrylate and the polyphosphoric acid in the step (1) into the aqueous solution of chitosan, reacting for 10-20 h at 50-80 ℃, dialyzing and freeze-drying to obtain modified calcium chloride; the weight ratio of the calcium chloride acrylate to the polyphosphoric acid is 1: 8-15;

the pH regulator is citric acid and sodium citrate.

2. The liquid oral composition according to claim 1, comprising a combination of herbal actives and tea tree essential oil,

the wetting agent comprises one or more of sorbitol, xylitol, maltitol, lactitol and ethylene glycol.

3. The liquid oral composition comprising herbal actives and tea tree essential oil as claimed in claim 1, wherein the preservative comprises one or more of sodium benzoate, methylparaben, ethylparaben, propylparaben, butylparaben, glycine alkyl diamino ethyl ester hydrochloride, potassium sorbate, propolis.

4. The liquid oral composition as claimed in claim 1, wherein the essence comprises one or more of spearmint oil, eucalyptus oil, wintergreen oil, clove oil, thyme oil, sage oil, cardamom oil, rosemary oil, marjoram oil, lemon oil, nutmeg oil, lavender oil, geranium oil, L-carvone, 1, 8-cineole, methyl salicylate, eugenol, thymol, linalool, limonene, menthone, menthyl acetate, citral, camphor, borneol, pinene, spilanthol.

5. The liquid oral composition containing a herbal active ingredient and tea tree essential oil according to claim 1, wherein the modified calcium chloride has a grafting ratio of 1 to 3%.

6. The method for preparing the liquid oral composition comprising the Chinese medicinal active substance and the tea tree essential oil according to any one of claims 1 to 5, comprising the steps of: