CN106562921A

CN106562921A - Liquid oral composition containing TCM active substances and tea tree essential oil

Info

Publication number: CN106562921A
Application number: CN201610943361.9A
Authority: CN
Inventors: 李浩然
Original assignee: Individual
Current assignee: Individual
Priority date: 2016-11-02
Filing date: 2016-11-02
Publication date: 2017-04-19
Anticipated expiration: 2036-11-02
Also published as: CN106562921B

Abstract

The invention provides a liquid oral composition containing TCM active substances and the tea tree essential oil. The liquid oral composition comprises the following materials in parts by weight: 1.0 to 10 parts of traditional Chinese medicine extracts, 0.1-6 parts of additives, 0.001-0.005 part of menthol, 0.001-0.006 part of tea tree essential oil, and 90-100 parts of water. The traditional Chinese medicine extracts are composed of green tea extract, affine cudweed extract, plantain herb extract, Lamium album extract, tea tree root extract, gallnut, honeysuckle and orange peel mixed extract, and violet extract. The additives are composed of a wetting agent, a pH regulator, a preservative, essence and a flocculating agent.

Description

One kind is containing active Chinese drug component material and tea tree ethereal oil liquid oral composition

Technical field

The present invention relates to oral care product technical field, more specifically, the present invention provides a kind of containing active Chinese drug component material With tea tree ethereal oil liquid oral composition.

Background technology

Mouthwash is the oral care product of people's daily life cleaning and health care in liquid oral composition, is mainly used in Oral cavity and cleaning of teeth are kept, is promoted breath freshening, is nursed gum, safeguards good microenvironment in oral cavity etc..

At present, the Chinese medicine mouth wash species that day is commonly used on market is a lot, and it is mainly in the mouthwash water of composition mouthwash Add corresponding traditional Chinese medicine ingredients in body matrix to form Chinese medicine mouth wash, it is used for multipotency and suppresses oral cavity harmful bacteria, anti-inflammatory town Bitterly, anti-desensitization, pre- anti-caries prevent and treat the periodontal diseases such as gingivitis, periodontitis, dental hemorrhage.

In order to give salubrious use feeling, usual mixed ethanol in mouthwash.But, ethanol can be accompanied by intraoral thorn Swash, easily cause the white lesions of oral mucosa, alcohol screen test concentration can be affected, be not suitable for the oral cavity after having a dinner party out and disappear Poison.

In addition, in for non-ethanol class mouthwash, emulsion is easily disintegrated, the appearance stability and mouthwash of mouthwash are affected Usability.

Tea tree ethereal oil has bactericidal antiphlogistic, can remove oral peculiar smell, prevents decayed tooth, keeps breath freshening.

Therefore, for above-mentioned problem, needing one kind badly being capable of oral cavity and cleaning of teeth, promotion breath freshening, nursing Gum, the good microenvironment in oral cavity is safeguarded, and the non-ethanol class with good appearance stability and usability is containing tea tree ethereal oil Liquid oral composition.

The content of the invention

First aspect present invention provides one kind containing active Chinese drug component material and tea tree ethereal oil liquid oral composition, by weight Amount part calculates, including：

Wherein, the Chinese medical extract includes green-tea extract, affine cudweed extract, Herba Plantaginis extract, short handle open country sesame Nettle extract, tea tree root extract, Chinese gall, honeysuckle and orange peel mixed extract, violet extract；The additive bag Include wetting agent, pH adjusting agent, preservative, essence and flocculant.

In one embodiment, the Chinese medical extract also includes that mint extract, qualities of stevia extract, heartsease carry Take thing, Carum carvi extract.

In one embodiment, the wetting agent includes D-sorbite, xylitol, maltitol, lactitol, ethylene glycol In one or more.

In one embodiment, the pH adjusting agent include phthalic acid, phosphoric acid, citric acid, butanedioic acid, acetic acid, One or more in fumaric acid, malic acid, carbonic acid, sodium dihydrogen phosphate, disodium-hydrogen, sodium citrate.

In one embodiment, the preservative includes Sodium Benzoate, methyl p-hydroxybenzoate, P-hydroxybenzoic acid The p-hydroxybenzoates such as ethyl ester, propylparaben, butyl p-hydroxybenzoate, glycine alkyl diaminourea ethyl ester salt One or more in hydrochlorate, potassium sorbate, propolis.

In one embodiment, the essence include spearmint oil, eucalyptus oil, wintergreen, caryophyllus oil, thyme linaloe oil, Sage oil, cardamom oil, rosemary oil, marjoram oil, lemon oil, mace oil, lavender oil, god's grass oil, L- Sheep's-parsleys Ketone, 1,8- cineoles, gaultherolin, eugenol, thymol, linalool, limonene, menthones, menthyl acetate, lemon One or more in aldehyde, camphor, borneol, firpene, spilanthol.

In one embodiment, the flocculant is modified chlorinated calcium, and the modified chlorinated calcium is that acrylic acid coats chlorine Change grafted chitosan after calcium.

In one embodiment, the percent grafting of the modified chlorinated calcium is 1～5%.

In one embodiment, the percent grafting of the modified chlorinated calcium is 1～3%.

Another aspect of the present invention provides a kind of system containing active Chinese drug component material and tea tree ethereal oil liquid oral composition Preparation Method, comprises the following steps：

（1）Chinese medical extract, menthol, tea tree ethereal oil and water are added by weight, is stirred, make the Chinese medical extract molten In Xie Yushui；

（2）Additive being added by weight, being sufficiently stirred for, filtered, take filtrate, Jing sterilization processings were obtained in described containing Pharmaceutically active substance and tea tree ethereal oil liquid oral composition.

The above-mentioned of the application and other features, aspect and advantage is more readily understood with reference to described further below.

Specific embodiment

The participation in the election detailed description for being preferable to carry out method of the invention below and including embodiment this can be more easily understood Bright content.Unless otherwise defined, all technologies used herein and scientific terminology have common with art of the present invention The identical implication that technical staff is generally understood that.When there is contradiction, the definition in this specification is defined.

As used herein term " by ... prepare " it is synonymous with "comprising".Term "comprising" used herein, " including ", " having ", " containing " or its any other deformation, it is intended that cover including for non-exclusionism.For example, the combination comprising listed elements Thing, step, method, product or device are not necessarily solely those key elements, and can be including not expressly listed other key elements or The intrinsic key element of this kind of composition, step, method, product or device.

Conjunction " Consists of " excludes any key element do not pointed out, step or component.If in being used for claim, this Phrase will make claim for closed so as to not comprising the material in addition to the material that those are described, but it is relative often Except rule impurity.When phrase " Consists of " is occurred in be rather than immediately following after theme in the clause of claim main body, It is only limited to the key element described in the clause；Other key elements are not excluded outside as the overall claim.

Equivalent, volume fraction or other values or parameter with scope, preferred scope or a series of upper limit preferred values and under During the Range Representation that limit preferred value is limited, this be appreciated that specifically disclose by any range limit or preferred value with it is any All scopes that arbitrary pairing of range lower limit or preferred value is formed, regardless of whether whether the scope separately discloses.For example, when When disclosing scope " 1 to 5 ", described scope should be interpreted as including scope " 1 to 4 ", " 1 to 3 ", " 1 to 2 ", " 1 to 2 and 4 to 5 ", " 1 to 3 and 5 " etc..When number range is described herein, unless otherwise indicated, otherwise the scope is intended to include Its end value and all integers within the range and fraction.

Singulative includes that plural number discusses object, unless the context clearly dictates otherwise." optional " or " arbitrarily It is a kind of " refer to that the item for describing thereafter or event may or may not occur, and the description include situation that event occurs and The situation that event does not occur.

Approximate term in specification and claims is used for modifying quantity, represents that the present invention is not limited to this concrete Quantity, also includes the acceptable part without causing the amendment of the change of related basic function being close to the quantity.Phase Answer, with " about ", a numerical value of the modification such as " about ", mean and the invention is not restricted to the exact numerical.In some examples, approximately Term likely corresponds to the precision of the instrument of measured value.In present specification and claims, scope is limited can be with Combine and/or exchange, if not stated otherwise these scopes include all subranges contained therebetween.

Additionally, key element of the present invention or indefinite article " one kind " and " one " before component are to key element or the quantitative requirement of component (i.e. occurrence number) unrestriction.Therefore " one " or " one kind " should be read as including one or at least one, and odd number The key element or component of form also includes plural form, unless the obvious purport of the quantity refers to singulative.

" blend " means that two or more polymer is mixed and formed jointly by physics or chemistry method Polymer.

In one embodiment, calculate by weight, 1～2 part of green-tea extract, affine cudweed in the Chinese medical extract 0.1～1 part of extract, 0.1～1 part of Herba Plantaginis extract, 0.5～1.5 part of Herba Lamii albi extract, tea tree root extract 0.1～1.0 part, 0.5～3 part of Chinese gall, honeysuckle and orange peel mixed extract, 0.01～0.1 part of violet extract, peppermint 0.1～1.2 part of extract, 0.05～1.0 part of qualities of stevia extract, 0.003～0.2 part of heartsease extract, Carum carvi are extracted 0.005～0.3 part of thing.

In one embodiment, calculate by weight, 1～5 part of the wetting agent, it is 0.1～0.3 part of pH adjusting agent, anti- 0.01～0.15 part of 0.01～0.1 part of rotten agent, 0.001～0.1 part of essence and flocculant.

Green tea

Green tea be it is not fermented made by tea, remain the natural materials of fresh leaf, Tea Polyphenols, catechin, the Ye Lv for containing Element, caffeine, amino acid, vitamins and other nutritious components are also more.These natural nutrition compositions in green tea are to anti-aging, anti- Cancer, anticancer, sterilization, anti-inflammatory etc. have special-effect.Green tea is that, with suitable And Development of Tea Shoot as raw material, Jing is completed, kneads, is dried Tealeaves made by typical process process.

Affine cudweed

Another name：Chrysanthemum Anacamptis pyromaidalis, affine cudweed, Tian Ai, affine cudweed, native bacterium old [Guangdong], distiller's yeast suede, mouse ear, swamp cudweed, mouse ear Grass, lemongrass, ant wine grass, chrysanthemum end in vain, fine and soft female, yellow wormwood artemisia, meter Qu, hair ear, water chrysanthemum, continuous wadding head grass, gold boiling grass, Di Lian, Huang Beggar's grass, water ant grass, clear and bright perfume, broadleaf globethistle inflorescence, cotton dish, spinach spinach grass, cotton cocoon head, wide tight careless, Clear and Bright wormwood artemisia, a cyanotic, the close Chinese mugwort of mouse, Water wormwood artemisia, target dish, Bai Toucao, water song, yorkshire fog grass, silk flosssilk wadding grass, sheep ear grass, goldhair grmnopteris herb or rhizome, pectinate rungia herb, cat pin medicinal herbs, Hua Focao, Mao mao's head grass, chrysanthemum fruit, glutinous rice green grass or young crops, cotton dish, white Chinese silvergrass, felt grass.Herb contains 5% glycosides displayed, 0.05% volatile oil, micro life Alkaloids and sterol, 0.58% it is non-shoulder compound, and containing Cobastab, carrot, chlorophyll, resin, fat etc..Flower -4- containing cyanidenon β-D-Glucose glucoside（luteline-4-β-D-glucoside）

Meridian distribution of property and flavor：It is sweet, put down.

Indication：It is relieving cough and asthma, hypotensive, wines used as antirheumatic.For cold cough, bronchitis, asthma, hypertension, silkworm Beans disease, lumbago, skelalgia of rheumatism；Traumatic injury, venomous snake bite are controlled in external application.

Asiatic plantain

Herb contains plantagin (Plantago astiatice L) Aucubin (Aucnbin). ursolic acid (Uraolicacid) .B- sitosterol, positive hentriacontane, palmitic acid B- paddy steroid acid esters, brown tamarind sterol ester, Cobastab, dimension Raw element C and plantaglucide (Plantaglusidc) (are by D- gala aldehydic acid methyl esters .D- half sugar, L-arabinose, L- sandlwoods Sugar etc. is constituted).Protein, butanedioic acid, adenine, choline, Catalpol, stearic acid, arachidic acid, leukotrienes, Asia there are not the aliphatic acid such as acid.

Nature and flavor and function：It is sweet, tremble with fear, return the hand sun, Yangming Channel.Li Shui, heat-clearing, improving eyesight, eliminating the phlegm, for urinary obstruction, is drenched Turbid, under band, hematuria, jaundice, oedema, hot dysentery is had loose bowels, nosebleed epistaxis, red eye, swell pain, laryngalgia, cough, skin ulcer.

Herba Lamii albi

Herba Lamii albi（Scientific name：Lamium album）For a plant species under Labiatae lamium.Spire is edible, Flower can be used as medicine, and herb contains saponin, tannin, caffeic acid and several amino acids.

Nature and flavor and function：Sweet, bitter, cold.Enter liver, kidney, the Jing of bladder three.Promoting blood circulation, swelling and pain relieving.

Tea root

The carbohydrates such as the aqueous threose of new fresh quench, gossypose, sucrose, glucose, fructose, and containing a small amount of polyphenolic substance (flavane Alcohol etc.).

Nature and flavor and function：It is bitter；It is cool.Enter the heart；Kidney channel.Cardiac stimulant diuresis；Promoting blood circulation for regulating menstruation；It is clearing heat and detoxicating.Main heart disease；Oedema； Hepatitis；Dysmenorrhoea；Sore swollen toxin；Aphtha；Soup fire burn；Herpes zoster；Psoriasis.

Chinese gall

Chinese gall angle assumes diamond in shape again or oval, has irregular horn shape branch, long 3-8 centimetre, 2-5 centimetre of diameter.Surface Yellow is fallow, and the soft sliding down of canescence is more apparent.Matter is hard and crisp, and hollow after crushing, wall is relatively thin, about 0.1-0.2 li Rice, cutin inside has most pitchy aphid corpse and grey powdery excreta.Inwall light brown, smooths.Section cutin.It is micro- to have Special foul smell, puckery.

The property of medicine：Acid, it is puckery, tremble with fear.Return lung, large intestine, kidney channel.

Effect：Astringe the lung fall fire, cough-relieving hidroschesis, relieving diarrhea with astringents, controlling nocturnal emission with astringent drugs is only lost, astringing to arrest bleeding, hygroscopic sore.

Cure mainly：Cough, hemoptysis, spontaneous perspiration, night sweat, chronic diarrhea, protracted dysentery, seminal emission, involuntary emission, uterine bleeding, hemorrhoid blood of having blood in stool, wet sore, pyogenic infections.

Honeysuckle

Honeysuckle, also known as honeysuckle, honeysuckle flower, honeysuckle etc., clearing heat and detoxicating good medicine is described as from ancient times.The sweet cold air fragrance of its property, Clear heat with drugs of sweet flavour and cold nature and do not injure one's stomach, fragrance is thoroughly up to again can eliminating evil.Honeysuckle can dispelling wind-heat, be also apt to removing summer-heat blood poison, for various heat Venereal disease, such as body heat, dermexanthesis, a spot, heat toxin sore carbuncle, abscess of throat card, equal effect is significant.According to version in 2005《Middle traditional Chinese medicines Allusion quotation》, honeysuckle is Caprifoliaceae woodbine honeysuckle（Lonicerajaponica Thunb）Dry flower or band just open Flower.

Honeysuckle has broad-spectrum antibacterial action, has stronger suppression to pathogenic bacteria such as staphylococcus aureus, shigella dysenteriaes Effect；There are obvious anti-inflammatory and refrigeration function；The water and steeping in wine liquid of honeysuckle has obvious cell to sarcoma 180 and ehrlich ascites tumor Poison is made, and also reduces cholesterol effect with certain.

Meridian distribution of property and flavor：It is sweet, tremble with fear.Return lung, the heart, stomach.

Effect application：It is clearing heat and detoxicating, dispelling wind and heat from the body.Carbuncle swells serious case of furuncle is cured mainly at the beginning of, red and swollen heat pain, affection of exogenous wind-heat, warm disease Rise, toxic-heat and blood stasis, hot summer weather polydipsia, abscess of throat.

Violet

Violet, Latin name：（Matthiola incana(L.)R.Br.）Cruciferae, Matthiola incana is biennial Or perennial herb.The close branch pubescence for being had handle by canescence of complete stool.Stem is upright, multi-branched, base portion slightly lignifying.Blade is oval Shape is to lanceolar or cochlear.

Violet can be clearing heat and detoxicating, whitening spot-removing, skin care, smoothing wrinkle ecchymose removing, removes oral peculiar smell, strengthens gloss, Resisting ultraviolet radiation, violet also has the effect of conditioning to the very useful of respiratory tract to bronchitis, can also wet one's whistle, and Solve the oral peculiar smell caused because of decayed tooth.

Peppermint

Peppermint, popular name, " lunar caustic grass ", is that labiate " peppermint " belongs to other together and is dried herb, is born in hill wet more By ground river, rhizome grows wild underground.Complete stool green gas fragrance.Leaf opposite, spends little lavender, lip that the granule of dark violet brown is tied after spending Really.

Peppermint has special fragrant, pungent sense and cool feeling, for the medicine such as wind dispelling, anti-corrosion, anti-inflammatory, analgesia, antipruritic, stomach invigorating In product.All herbal medicine, it is pungent, it is cool.Return lung, Liver Channel, there is a diverging wind-heat, clearing throat, promoting eruption removing toxic substances, soothing liver-qi stagnation and the work(such as antipruritic Effect, it is adaptable to which cold, fever, headache, abscess of throat, the fiery cute conjunctivitis of lossless, wind, rubella, skin are itched, colic, diarrhea and scrofula etc. Disease, external application has slight analgesic effect, for neuralgia etc..

STEVIA REBAUDIANA

Leaf containing Stevioside, steviolbioside, Stevioside A and Stevioside B, sweet glucoside A, sweet glucoside B, sweet glucoside C, D, E, euonymin A, 6-O- acetyl group Australia euparin, eupatol, Australia's euparin.

Meridian distribution of property and flavor：It is sweet, tremble with fear；Return lung, the Jing of stomach two.

Efficacy effect：Promote the production of body fluid to quench thirst；It is hypotensive.Master quenches one's thirst；High blood pressure.

Orange peel

Orange peel is the pericarp of rutaceae sweet orange.Sweet orange evergreen dungarunga, cultivates in hills, low mountain zone and rivers lake Pool is littoral, and there is cultivation various places on the south China the Changjiang river, and kind is numerous.At the beginning of winter or spring, the pericarp for stripping down is dried or dried.

Meridian distribution of property and flavor：Warm in nature, sweet-bitter flavor is nontoxic；Enter spleen, the Jing of lung two.

Efficacy effect：Qi-regulating, resolving sputum, invigorating the spleen is led stagnant.Cure cold cough, and poor appetite, chest and abdomen swelling and pain, borborygmus are just rushed down, breast Carbuncle.

Heartsease

Heartsease（Scientific name：Viola tricolor L.）It is the annual or short-term perennial herb of Violaceae Viola Plant.Stem, leaf contain violanthin；Flower contains rutin, volatile oil, saponin, vitamin A, C.Heartsease can sterilized, treatment skin Upper whelk, acne, allergic problem.Traditional Chinese medical science canon《Compendium of Materia Medica》The mystery for containing heartsease in detail goes acne effect：" three colors Violet, property table is gentle, and its taste fragrance, priming is up in face, goes sore except scar, sore detumescence." heartsease herb, medicine is can serve as, Cauline leaf cures mainly the diseases such as cough containing heartsease element.

Meridian distribution of property and flavor：It is cold, bitter；Return through, lung channel.

Efficacy effect：It is clearing heat and detoxicating；Cough-relieving.Main sore swollen toxin；Infantile eczema；Infantile scrofula；Cough.

Carum carvi

Carum carvi is the fruit of samphire Fen wormwood artemisias.Fruit claims caraway oil 3.5～7% containing volatile oil, in oil it is main into It is divided into d- Eucarvones 50～60% and d- lemon rafter alkene etc..

Meridian distribution of property and flavor：It is warm in nature, it is sweet pungent；Enter kidney, stomach.

Efficacy effect：Fragrant stomach invigorating, wind dispelling qi-regulating.Treat for stomachache, suffer from abdominal pain, herria.

Green-tea extract extracting method：

Tea polysaccharide：Tea sample 20g after crushing is taken, with the distilled water for being preheated to 55 DEG C with 1：The ratio of 20 (w/v) is in 55 DEG C Stirring and leaching 2.5h in water-bath, with the centrifugation 15min of 4000r/min after filtration, takes supernatant, concentration, then with 3 times 95% ethanol precipitation of volume, is centrifuged to obtain tea polysaccharide precipitation, and tea polysaccharide is obtained after freeze-drying.

Tea Polyphenols：Tea sample 20g after crushing is taken, with the distilled water for being preheated to 55 DEG C with 1：The ratio of 20 (w/V) is in 55 DEG C Stirring and leaching 2.5h in water-bath, with the centrifugation 15min of 400Or/min after filtration, takes supernatant, concentration, uses A1³⁺ Tea Polyphenols is precipitated in pH5.3-5.7 environment, Tea Polyphenols-aluminum precipitation Jing turns molten, and equal-volume ethyl acetate is extracted 3 times, vacuum refrigeration Tea Polyphenols (I) is obtained after drying；Appropriate supernatant being taken again, being concentrated, equal-volume ethyl acetate is extracted 3 times, after vacuum freeze drying Tea Polyphenols (II).

Affine cudweed extract extracting method：

Weigh after 20.0g affine cudweeds are dried and are crushed, add the ethanol that mass concentration is 70%～80%, immersion 2～ Using extracting through microwave heating 2～3 times after 3h, filter, filtrate Jing is evaporated to without ethanol, obtains final product.

Herba Plantaginis extract extracting method：

Weigh after 20.0g Asiatic plantains are dried and are crushed, add the ethanol that mass concentration is 80%～90%, immersion 2～ Using extracting through microwave heating 2～3 times after 3h, filter, filtrate Jing is evaporated to without ethanol, obtains final product.

Herba Lamii albi extract extracting method：

Herba Lamii albi is spent into clean, chopping, mass concentration is subsequently adding for 3～5g/L aqueous citric acid solutions, immersion 2～ Using extracting through microwave heating 2～3 times after 3h, filter, filtrate Jing drying under reduced pressure is obtained final product.

Tea tree root extract extracting method：

20.0g tea roots are weighed, cleaned, be dried and after being crushed, add the ethanol that mass concentration is 75%～85%, leaching Using extracting through microwave heating 2～3 times after 2～3h of bubble, filter, filtrate Jing is evaporated to without ethanol, obtains final product.

Violet extract extracting method：

Dry violet 20.0g is weighed, after crushing, in adding 100 DEG C of hot water, 1h is soaked, concentration is then added For 80%～85% ethanol, using extracting through microwave heating 1～3 time, microwave power is 80～100W, is filtered, and filtrate Jing decompressions are dense It is reduced to without ethanol, obtains final product.

Mint extract extracting method：

Peppermint is taken, meal is ground into, supercritical CO is placed in₂Extraction equipment, parsing pressure 6MPa, 35 DEG C of resolution temperature, Extraction time 3.0h, 45 DEG C of extraction temperature, extracting pressure 35MPa, CO₂Flow 40kg/h, obtains mint extract.

Qualities of stevia extract extracting method：

STEVIA REBAUDIANA is taken, meal is ground into, supercritical CO is placed in₂Extraction equipment, in parsing pressure 6MPa, resolution temperature 40 DEG C, extraction time 3.0h, 55 DEG C of extraction temperature, extracting pressure 40MPa, CO₂Flow 50kg/h, obtains qualities of stevia extract.

Chinese gall, honeysuckle and orange peel mixed extract extracting method：

By Chinese gall, honeysuckle and orange peel by weight mixing, explosion is crushed to 100-200 mesh, and the 2- of 0.1 weight portion Mercaptobenzothiazoler is blended, and is extracted as solvent with ethanol, and flow back 2h, filters while hot, is concentrated into without ethanol, obtains final product.

In one embodiment, the Chinese gall and the weight ratio of honeysuckle, orange peel are 1：0.3：0.2.

Heartsease extract extracting method：

Dry heartsease 20.0g is weighed, after crushing, in adding 90 DEG C of hot water, 2h is soaked, then adding concentration is 75%～85% ethanol, using extracting through microwave heating 1～3 time, microwave power is 80～100W, is filtered, filtrate Jing reduced pressure concentrations To without ethanol, obtain final product.

Carum carvi extract extracting method：

Dry Carum carvi 20.0g is weighed, after crushing, in adding 100 DEG C of hot water, 2h is soaked, concentration is then added For 95% ethanol, using extracting through microwave heating 1～3 time, microwave power is 80～100W, is filtered, and filtrate Jing is evaporated to nothing Ethanol, obtains final product.

Tea tree ethereal oil

Tea tree ethereal oil originates in Australia, is the extract of tea tree.With bactericidal antiphlogistic, convergence pore, treatment cold, Cough, rhinitis, asthma, the effects such as improve dysmenorrhoea, irregular menstruation and genital infection.Suitable for oiliness and acne-prone skin, treatment Suppurative wound and burn, tan severely, athlete's foot and dandruff.Clear the head, rejuvenate, anti-depression.

Topmost chemical composition is to Meng ethene (terpinene）, dipentene (pinene）, limonene （limonene）, cineol（cineole）, sesame oil brain（terpineol）, anisoxide（cumene）.

Its extracting method is, with blade and tender tip as raw material, to be extracted using vapor distillation method, and oil yield is 1.8%.

PH adjusting agent

PH value regulator is also known as pH adjusting agent, acidity regulator or pH value controlling agent etc., using adjusting or keep pH value （Acid or alkali）A kind of food additives.Acidity regulator can be organic acid or inorganic acid, alkali, nertralizer or buffer.

Acidity regulator has many functional characteristics for promoting food quality, for example, change and maintain the acidity of food and change It is apt to its local flavor；Promote antioxidation, prevent food from becoming sour；With complex, with prevent oxidation or browning reaction, The effects such as stable color, reduction turbidity, enhancing gelling characteristic.

In one embodiment, the pH adjusting agent include phthalic acid, phosphoric acid, citric acid, butanedioic acid, acetic acid, One or more in fumaric acid, malic acid, carbonic acid, sodium dihydrogen phosphate, disodium-hydrogen, sodium citrate；Preferably, the pH is adjusted Section agent is citric acid, sodium citrate.

In one embodiment, the citric acid and the weight ratio of the sodium citrate are 1：0.8.

Preservative

Preservative refers to naturally occurring or synthetic chemical composition, to keep the original quality of food and nutritive value for the purpose of Food additives.Preservative Main Function is the growth and breeding for suppressing microorganism, to extend the holding time of food, mortifier The corrupt medicament of matter.Food preservative can suppress microbial activities, and prevent food spoilage goes bad, so as to extend guaranteeing the quality for food Phase.

In one embodiment, the preservative includes Sodium Benzoate, methyl p-hydroxybenzoate, P-hydroxybenzoic acid The p-hydroxybenzoates such as ethyl ester, propylparaben, butyl p-hydroxybenzoate, glycine alkyl diaminourea ethyl ester salt One or more in hydrochlorate, potassium sorbate, propolis；Preferably, the preservative is propolis.

Essence

Essence is by the artificial synthesized concentration aromatic oil for imitating fruit and natural perfume material smell.

In one embodiment, the essence include spearmint oil, eucalyptus oil, wintergreen, caryophyllus oil, thyme linaloe oil, Sage oil, cardamom oil, rosemary oil, marjoram oil, lemon oil, mace oil, lavender oil, god's grass oil, L- Sheep's-parsleys Ketone, 1,8- cineoles, gaultherolin, eugenol, thymol, linalool, limonene, menthones, menthyl acetate, lemon One or more in aldehyde, camphor, borneol, firpene, spilanthol；Preferably, the essence includes spearmint oil, eucalyptus oil, winter Blue or green oil, caryophyllus oil, thyme linaloe oil, sage oil, cardamom oil, rosemary oil, marjoram oil, lemon oil, mace oil, smoke clothing Careless oil, god's grass oil, one or more of limonene；It is highly preferred that the essence is lemon oil, one kind of limonene or many Kind.

In one embodiment, the preparation method of the modified chlorinated calcium is as follows：

（1）It is in 50 DEG C of high-speed mixers, by weight acrylic acid is added, to stir 0.5 that calcium chloride is added into barrel temperature After～2h, discharging after high-speed mixer barrel temperature is risen to 120 DEG C, above-mentioned material is refunded in high-speed mixer, high-speed stirring Mix and discharged after 0.5～1h, obtain acrylic acid cladding calcium chloride；The acrylic acid is 1 with the weight ratio of the calcium chloride：（10～ 20）；

（2）Shitosan is substantially dissolved in water, the aqueous solution that chitosan concentration is 0.02mol/L is made, to shitosan The aqueous solution adds step（1）Described in acrylic acid calcium chloride and polyphosphoric acids, at 50～80 DEG C, react 10～20h, dialysis is lyophilized After obtain modified chlorinated calcium；The acrylic acid calcium chloride is 1 with the weight ratio of the polyphosphoric acids：（8～15）.

The present invention can also safeguard liquid port by the fungistatic effect that modified chlorinated calcium not only improves liquid oral composition The stability of chamber composition, it is to avoid the layering of material.

In the present invention, under the conditions of 15～30 DEG C, solubility 0.5g of the modified chlorinated calcium in water.

The present invention is very high by the reactivity of acrylic acid AA, and its one end is highly acid carboxyl, can be with calcium chloride surface It is bonded, acrylic acid is combined in the calcium chloride surface with loose structure, the shitosan with fine fungistatic effect and propylene Sour calcium chloride carries out graft reaction, and the modified chlorinated calcium surface for obtaining covers the polarity that organic matter contains carboxyl, hydroxyl, amino etc. Group, makes modified chlorinated calcium have surface oleophylic, hydrophilic radical, can not only well improve the steady of liquid oral composition It is qualitative, also with good fungistatic effect.

In one embodiment, the sterilization processing is to adopt high-temperature short-time sterilization.

High-temperature short-time sterilization

High-temperature short-time sterilization, refers to and make culture medium temperature be rapidly reached 130～140 using the saturated vapor under heating condition DEG C, cultivation temperature is cooled to quickly after maintaining a few minutes, complete the process for sterilizing.Its advantage can kill more heat-resisting Microbial spore can to greatest extent reduce the destruction of nutrient content again, improve the utilization rate of raw material.

Green-tea extract, affine cudweed extract, Herba Lamii albi extract, tea tree root extract, Chinese gall in the present invention Extract, Honegsukle flower P.E, mint extract can clear implication, bactericidal antiphlogistic；Violet extract, STEVIA REBAUDIANA are extracted Thing, Extract from Orange Peel, heartsease extract, Carum carvi extract adjust mouthfeel.

Liquid oral composition containing Chinese medical extract not only excellent taste in the present invention, alleviates oral cavity uncomfortable diseases Shape, keeps good Tiny ecosystem, and also has functions that anti-inflammatory analgetic；Present invention, avoiding alcohol and easily cause oral mucosa White lesions, and using liquid oral composition mouth affect alcohol screen test concentration, after being particularly suitable for having a dinner party out Oral disinfecting.

The present invention is specifically described below by embodiment.Be necessary it is pointed out here that, following examples are only used In the invention will be further described, it is impossible to be interpreted as limiting the scope of the invention, professional and technical personnel in the field According to some nonessential modifications and adaptations that the content of the invention described above is made, protection scope of the present invention is still fallen within.

In addition, if without other explanation, it is raw materials used be all it is commercially available, be purchased from traditional Chinese medicines chemical reagent.

Embodiment 1

The preparation method containing active Chinese drug component material and tea tree ethereal oil liquid oral composition, including following step Suddenly：

It is described to calculate by weight containing active Chinese drug component material and tea tree ethereal oil liquid oral composition, including：Green tea 1.6 parts of extract, 0.7 part of affine cudweed extract, 0.5 part of Herba Plantaginis extract, 1.0 parts of Herba Lamii albi extract, tea root 0.6 part of extract, 2.3 parts of Chinese gall, honeysuckle and orange peel mixed extract, 0.02 part of violet extract, mint extract 0.35 part, 0.12 part of qualities of stevia extract, 0.005 part of heartsease extract, 0.007 part of Carum carvi extract, the xylitol 3.1 parts, citric acid and 0.15 part of sodium citrate, 0.05 part of propolis, limonene and 0.003 part of lemon oil and modified chlorinated calcium 0.06 Part, 0.002 part of menthol, 0.003 part of tea tree ethereal oil, 92 parts of water；The Chinese gall is 1 with the weight ratio of honeysuckle, orange peel： 0.3：0.2；The citric acid is 1 with the weight ratio of the sodium citrate：0.8；The weight of the limonene and the lemon oil Than for 1：0.6.

The preparation method of the modified chlorinated calcium comprises the steps：

（1）It is in 50 DEG C of high-speed mixers, by weight acrylic acid is added, to stir 1h that calcium chloride is added into barrel temperature Afterwards, discharge, after high-speed mixer barrel temperature is risen to 120 DEG C, above-mentioned material is refunded in high-speed mixer, high-speed stirred 1h After discharge, obtain acrylic acid cladding calcium chloride；The acrylic acid is 1 with the weight ratio of the calcium chloride：13；

（2）Shitosan is substantially dissolved in water, the aqueous solution that chitosan concentration is 0.02mol/L is made, to shitosan The aqueous solution adds step（1）Described in acrylic acid calcium chloride and polyphosphoric acids, at 60 DEG C, react 18h, changed after dialysis is lyophilized Property calcium chloride；The acrylic acid calcium chloride is 1 with the weight ratio of the polyphosphoric acids：10.

Embodiment 2

It is described to calculate by weight containing active Chinese drug component material and tea tree ethereal oil liquid oral composition, including：Green tea 2 parts of extract, 0.1 part of affine cudweed extract, 0.1 part of Herba Plantaginis extract, 0.5 part of Herba Lamii albi extract, tea root is carried Take 0.1 part of thing, 3 parts of Chinese gall, honeysuckle and orange peel mixed extract, 0.02 part of violet extract, 1 part of mint extract, 0.12 part of qualities of stevia extract, 0.003 part of heartsease extract, 0.1 part of Carum carvi extract, 3.1 parts of the xylitol, lemon Acid and 0.003 part of 0.15 part of sodium citrate, 0.05 part of propolis, limonene and lemon oil and 0.06 part of modified chlorinated calcium, menthol 0.002 part, 0.003 part of tea tree ethereal oil, 92 parts of water；The Chinese gall is 1 with the weight ratio of honeysuckle, orange peel：0.3：0.2；Institute It is 1 that citric acid is stated with the weight ratio of the sodium citrate：0.8；The limonene is 1 with the weight ratio of the lemon oil：0.6.

The preparation method and the modified chlorine containing active Chinese drug component material and tea tree ethereal oil liquid oral composition Change the preparation method of calcium with embodiment 1.

Embodiment 3

It is described to calculate by weight containing active Chinese drug component material and tea tree ethereal oil liquid oral composition, including：Green tea 2 parts of extract, 1 part of affine cudweed extract, 1 part of Herba Plantaginis extract, 1.5 parts of Herba Lamii albi extract, tea tree root extract 0.6 part, 0.5 part of Chinese gall, honeysuckle and orange peel mixed extract, 0.05 part of violet extract, 0.1 part of mint extract, 0.12 part of qualities of stevia extract, 0.005 part of heartsease extract, 0.007 part of Carum carvi extract, 3.1 parts of the xylitol, lemon Lemon acid and 0.003 part of 0.15 part of sodium citrate, 0.05 part of propolis, limonene and lemon oil and 0.06 part of modified chlorinated calcium, peppermint 0.002 part of alcohol, 0.003 part of tea tree ethereal oil, 92 parts of water；The Chinese gall is 1 with the weight ratio of honeysuckle, orange peel：0.3：0.2； The citric acid is 1 with the weight ratio of the sodium citrate：0.8；The limonene is 1 with the weight ratio of the lemon oil： 0.6。

Embodiment 4

It is described to calculate by weight containing active Chinese drug component material and tea tree ethereal oil liquid oral composition, including：Green tea 1.6 parts of extract, 0.7 part of affine cudweed extract, 0.5 part of Herba Plantaginis extract, 1.0 parts of Herba Lamii albi extract, tea root 0.6 part of extract, 2.3 parts of Honegsukle flower P.E, 0.02 part of violet extract, 0.35 part of mint extract, STEVIA REBAUDIANA are extracted 0.12 part of thing, 0.003 part of heartsease extract, 0.007 part of Carum carvi extract, 3.1 parts of the xylitol, citric acid and lemon 0.003 part of 0.15 part of sour sodium, 0.05 part of propolis, limonene and lemon oil and 0.06 part of modified chlorinated calcium, 0.002 part of menthol, 0.003 part of tea tree ethereal oil, 92 parts of water；The citric acid is 1 with the weight ratio of the sodium citrate：0.8；The limonene and institute The weight ratio for stating lemon oil is 1：0.6.

The Honegsukle flower P.E extracting method：

Weigh after 20.0g honeysuckles are dried and are crushed, add the ethanol that mass concentration is 85%～95%, immersion 2～ Using extracting through microwave heating 2～3 times after 3h, filter, filtrate Jing is evaporated to without ethanol, obtains final product.

Embodiment 5

It is described to calculate by weight containing active Chinese drug component material and tea tree ethereal oil liquid oral composition, including：Green tea 1.6 parts of extract, 0.7 part of affine cudweed extract, 0.5 part of Herba Plantaginis extract, 1.0 parts of Herba Lamii albi extract, tea root 0.6 part of extract, 2.3 parts of nutgall extractive, 0.02 part of violet extract, 0.35 part of mint extract, STEVIA REBAUDIANA are extracted 0.12 part of thing, 0.003 part of heartsease extract, 0.007 part of Carum carvi extract, 3.1 parts of the xylitol, citric acid and lemon 0.003 part of 0.15 part of sour sodium, 0.05 part of propolis, limonene and lemon oil and 0.06 part of modified chlorinated calcium, 0.002 part of menthol, 0.003 part of tea tree ethereal oil, 92 parts of water；The citric acid is 1 with the weight ratio of the sodium citrate：0.8；The limonene and institute The weight ratio for stating lemon oil is 1：0.6.

The nutgall extractive extracting method：

Weigh 20.0g Chinese galls to clean, be dried and after being crushed, add the ethanol that mass concentration is 70%～85%, leaching Using extracting through microwave heating 2～3 times after 2～3h of bubble, filter, filtrate Jing is evaporated to without ethanol, obtains final product.

Embodiment 6

It is described to calculate by weight containing active Chinese drug component material and tea tree ethereal oil liquid oral composition, including：Green tea 1.6 parts of extract, 0.7 part of affine cudweed extract, 0.5 part of Herba Plantaginis extract, 1.0 parts of Herba Lamii albi extract, tea root 0.6 part of extract, 2.3 parts of Extract from Orange Peel, 0.02 part of violet extract, 0.35 part of mint extract, qualities of stevia extract 0.12 part, 0.003 part of heartsease extract, 0.007 part of Carum carvi extract, 3.1 parts of the xylitol, citric acid and citric acid 0.003 part of 0.15 part of sodium, 0.05 part of propolis, limonene and lemon oil and 0.06 part of modified chlorinated calcium, 0.002 part of menthol, tea 0.003 part of essential oil of tree, 92 parts of water；The citric acid is 1 with the weight ratio of the sodium citrate：0.8；The limonene with it is described The weight ratio of lemon oil is 1：0.6.

The Extract from Orange Peel extracting method：

Weigh after 20.0g orange peels are dried and are crushed, add the ethanol that mass concentration is 50%～60%, soak 2～3h Afterwards using extracting through microwave heating 2～3 times, filter, filtrate Jing is evaporated to without ethanol, obtains final product.

Embodiment 7

It is described to calculate by weight containing active Chinese drug component material and tea tree ethereal oil liquid oral composition, including：Mouse is bent 0.7 part of careless extract, 0.5 part of Herba Plantaginis extract, 1.0 parts of Herba Lamii albi extract, the mixing of Chinese gall, honeysuckle and orange peel 2.3 parts of extract, 0.02 part of violet extract, 0.35 part of mint extract, 0.12 part of qualities of stevia extract, heartsease are extracted 0.003 part of thing, 0.007 part of Carum carvi extract, 3.1 parts of the xylitol, 0.15 part of citric acid, 0.05 part of propolis, lemon oil 0.003 part and 0.06 part of modified chlorinated calcium, 0.002 part of menthol, 0.003 part of tea tree ethereal oil, 92 parts of water；The Chinese gall and gold Honeysuckle flower, the weight ratio of orange peel are 1：0.3：0.2.

Embodiment 8

It is described to calculate by weight containing active Chinese drug component material and tea tree ethereal oil liquid oral composition, including：Green tea 1.6 parts of extract, 0.7 part of affine cudweed extract, 0.5 part of Herba Plantaginis extract, 1.0 parts of Herba Lamii albi extract, tea root 0.6 part of extract, 2.3 parts of Chinese gall, honeysuckle and orange peel mixed extract, 0.02 part of violet extract, mint extract 0.35 part, 0.12 part of qualities of stevia extract, 0.005 part of heartsease extract, 0.007 part of Carum carvi extract, the xylitol 3.1 parts, citric acid and 0.15 part of sodium citrate, 0.05 part of propolis, limonene and 0.003 part of lemon oil and modified chlorinated calcium 0.01 Part, 0.002 part of menthol, 0.003 part of tea tree ethereal oil, 92 parts of water；The Chinese gall is 1 with the weight ratio of honeysuckle, orange peel： 0.3：0.2；The citric acid is 1 with the weight ratio of the sodium citrate：0.8；The weight of the limonene and the lemon oil Than for 1：0.6.

Embodiment 9

It is described to calculate by weight containing active Chinese drug component material and tea tree ethereal oil liquid oral composition, including：Green tea 1.6 parts of extract, 0.7 part of affine cudweed extract, 0.5 part of Herba Plantaginis extract, 1.0 parts of Herba Lamii albi extract, tea root 0.6 part of extract, 2.3 parts of Chinese gall, honeysuckle and orange peel mixed extract, 0.02 part of violet extract, mint extract 0.35 part, 0.12 part of qualities of stevia extract, 0.005 part of heartsease extract, 0.007 part of Carum carvi extract, the xylitol 3.1 parts, citric acid and 0.15 part of sodium citrate, 0.05 part of propolis, limonene and 0.003 part of lemon oil and modified chlorinated calcium 0.15 Part, 0.002 part of menthol, 0.003 part of tea tree ethereal oil, 92 parts of water；The Chinese gall is 1 with the weight ratio of honeysuckle, orange peel： 0.3：0.2；The citric acid is 1 with the weight ratio of the sodium citrate：0.8；The weight of the limonene and the lemon oil Than for 1：0.6.

Comparative example 1

It is described to calculate by weight containing active Chinese drug component material and tea tree ethereal oil liquid oral composition, including：Green tea 1.6 parts of extract, 0.7 part of affine cudweed extract, 0.5 part of Herba Plantaginis extract, 1.0 parts of Herba Lamii albi extract, tea root 0.6 part of extract, 2.3 parts of Chinese gall, honeysuckle and orange peel mixed extract, 0.02 part of violet extract, mint extract 0.35 part, 0.12 part of qualities of stevia extract, 0.005 part of heartsease extract, 0.007 part of Carum carvi extract, the xylitol 3.1 parts, citric acid and 0.15 part of sodium citrate, 0.05 part of propolis, limonene and 0.003 part of lemon oil and modified chlorinated calcium 0.06 Part, 0.002 part of menthol, 0.003 part of tea tree ethereal oil, 92 parts of water；The Chinese gall is 1 with the weight ratio of honeysuckle, orange peel： 0.3：0.2；The citric acid is 1 with the weight ratio of the sodium citrate：0.8；The weight of the limonene and the lemon oil Than for 1：0.6；The modified chlorinated calcium is that acrylic acid coats calcium chloride.

It is in 50 DEG C of high-speed mixers, by weight acrylic acid is added, after stirring 1h, to go out that calcium chloride is added into barrel temperature Material, after high-speed mixer barrel temperature is risen to 120 DEG C, above-mentioned material is refunded in high-speed mixer, is gone out after high-speed stirred 1h Material, obtains acrylic acid cladding calcium chloride；The acrylic acid is 1 with the weight ratio of the calcium chloride：13.

The preparation method containing active Chinese drug component material and tea tree ethereal oil liquid oral composition is with embodiment 1.

Comparative example 2

It is described to calculate by weight containing active Chinese drug component material and tea tree ethereal oil liquid oral composition, including：Green tea 1.6 parts of extract, 0.7 part of affine cudweed extract, 0.5 part of Herba Plantaginis extract, 1.0 parts of Herba Lamii albi extract, tea root 0.6 part of extract, 2.3 parts of Chinese gall, honeysuckle and orange peel mixed extract, 0.02 part of violet extract, mint extract 0.35 part, 0.12 part of qualities of stevia extract, 0.005 part of heartsease extract, 0.007 part of Carum carvi extract, the xylitol 3.1 parts, citric acid and 0.003 part of 0.15 part of sodium citrate, 0.05 part of propolis, limonene and lemon oil and 0.06 part of calcium chloride, 0.002 part of menthol, 0.003 part of tea tree ethereal oil, 92 parts of water；The Chinese gall is 1 with the weight ratio of honeysuckle, orange peel：0.3： 0.2；The citric acid is 1 with the weight ratio of the sodium citrate：0.8；The limonene is with the weight ratio of the lemon oil 1：0.6.

Comparative example 3

It is described to calculate by weight containing active Chinese drug component material and tea tree ethereal oil liquid oral composition, including：Chinese herbaceous peony 0.5 part of careless extract, 2.3 parts of Extract from Orange Peel, 0.02 part of violet extract, 0.12 part of qualities of stevia extract, heartsease carry Take 0.005 part of thing, 0.007 part of Carum carvi extract, 3.1 parts of the xylitol, citric acid and 0.15 part of sodium citrate, propolis 0.06 part of 0.003 part of 0.05 part, limonene and lemon oil and modified chlorinated calcium, 0.002 part of menthol, 0.003 part of tea tree ethereal oil, 92 parts of water；The citric acid is 1 with the weight ratio of the sodium citrate：0.8；The weight ratio of the limonene and the lemon oil For 1：0.6.

Performance test：

1st, the evaluation of appearance stability：

450ml sample liquids composition for oral cavity is filled into into the pet container of full scale 450ml, range estimation is judged at 50 DEG C Thermostat in preserve 3 months after or in -10 DEG C of thermostat preserve 3 months after stability.Appearance stability (50 DEG C, 3 Individual month) metewand：

It is good：The tone of preparation is not changed in；

Typically：The tone of preparation only a little fades but level out of question；

Difference：The tone of preparation has colour fading.

The metewand of appearance stability (- 10 DEG C, 3 months)：

It is good：It is not changed in；

Typically：It can be seen that very little separation, but level out of question；

Difference：The tone for having separation, preparation also has colour fading.

2nd, mouthfeel

The people of experimenter 10, after mouth containing 10ml samples (liquid oral composition) is gargled 30 seconds, evaluation is gargled using preparation The continuation of refrigerant sense after 10 minutes, it is detained the sense of reality and without viscous sense, according to following benchmark the average mark of 10 people is judged.

（1）The continuation of refrigerant sense

5 points：The continuation of refrigerant sense is felt strongly

4 points：The continuation of refrigerant sense is felt strongly

3 points：Feel the continuation of refrigerant sense

2 points：Continuation of the fundamental sensation less than refrigerant sense

1 point：The continuation of imperceptible refrigerant sense；

（2）It is detained the sense of reality

4 points：Residual sense of the collutory in mouth is felt strongly

3 points：Feel residual sense of the collutory in mouth

2 points：Residual sense of the fundamental sensation less than collutory in mouth

1 point：Residual sense of the imperceptible collutory in mouth；

（3）Viscous sense

4 points：Imperceptible viscous sense

3 points：Fundamental sensation is less than viscous sense

2 points：Feel viscous sense

1 point：Viscous sense is felt strongly.

3rd, bacteriostatic activity

By liquid oral composition in embodiment and comparative example in aseptic operating platform, physiology also as a control group Saline solution all respectively takes 9ml, and is added into respectively in sterile glass test tube.Then, 1ml is added in each sterile glass test tube Colibacillary bacterium solution (shading value (O.D) is 0.1, and clump count is 106CFU/ml) mixes with it and carries out optical densitometric method measurement.Again Taking out bacterium solution by each sterile glass test tube simultaneously and the bacterium solution of dilution is applied in solid medium carries out applying the measurement of disk method. Each sterile glass test tube and each solid medium are placed in 37 DEG C of constant incubator are afterwards cultivated 8 hours, then determined Light absorption value after each sterile glass Tube propagation and each clump count applied after disk culture.

The bacteriostatic activity for applying disk method is that control group applies the clump count after the clump count and experimental group painting disk culture after disk culture Difference divided by control group apply disk culture after clump count.Escherichia coli, staphylococcus aureus and Pseudomonas aeruginosa are carried out respectively Test, obtains the data of bacteriostatic activity.

The performance test results of table 1

As can be seen that coating calcium chloride with acrylic acid, calcium chloride is bent without green-tea extract, mouse from above-mentioned test result Careless extract, Herba Lamii albi extract, tea tree root extract, nutgall extractive, Honegsukle flower P.E, mint extract Comparative example is compared, the present invention not only excellent taste, alleviates oral cavity malaise symptoms, keeps good Tiny ecosystem, and also with disappearing Effect of scorching pain relieving.

Aforesaid example is merely illustrative, for explaining some features of the method for the invention.Appended right will The scope as wide as possible for being intended to require to be contemplated that is sought, and embodiments as presented herein is only according to all possible enforcement The explanation of the embodiment of the selection of the combination of example.Therefore, the purpose of applicant is that appended claim is not illustrated this The selectional restriction of the example of bright feature.In the claims some number ranges used also include sub- model within Enclose, the change in these scopes also should be construed in the conceived case be covered by appended claim.

Claims

It is 1. a kind of to contain active Chinese drug component material and tea tree ethereal oil liquid oral composition, it is characterised in that to calculate by weight, Including：

Wherein, the Chinese medical extract includes green-tea extract, and affine cudweed extract, Herba Plantaginis extract, Herba Lamii albi is carried Take thing, tea tree root extract, Chinese gall, honeysuckle and orange peel mixed extract, violet extract；The additive includes profit Humectant, pH adjusting agent, preservative, essence and flocculant.
2. according to claim 1 containing active Chinese drug component material and tea tree ethereal oil liquid oral composition, it is characterised in that The Chinese medical extract also includes mint extract, qualities of stevia extract, heartsease extract, Carum carvi extract.
3. according to claim 1 containing active Chinese drug component material and tea tree ethereal oil liquid oral composition, it is characterised in that

The wetting agent is included one or more in D-sorbite, xylitol, maltitol, lactitol, ethylene glycol.
4. according to claim 1 containing active Chinese drug component material and tea tree ethereal oil liquid oral composition, it is characterised in that The pH adjusting agent includes phthalic acid, phosphoric acid, citric acid, butanedioic acid, acetic acid, fumaric acid, malic acid, carbonic acid, di(2-ethylhexyl)phosphate One or more in hydrogen sodium, disodium-hydrogen, sodium citrate.
5. according to claim 1 containing active Chinese drug component material and tea tree ethereal oil liquid oral composition, it is characterised in that The preservative includes Sodium Benzoate, methyl p-hydroxybenzoate, ethyl-para-hydroxybenzoate, propylparaben, right It is a kind of in the p-hydroxybenzoates such as butoben, glycine alkyl diaminourea carbethoxy hydrochloride, potassium sorbate, propolis Or it is various.
6. according to claim 1 containing active Chinese drug component material and tea tree ethereal oil liquid oral composition, it is characterised in that The essence includes spearmint oil, eucalyptus oil, wintergreen, caryophyllus oil, thyme linaloe oil, sage oil, cardamom oil, rosemary Oil, marjoram oil, lemon oil, mace oil, lavender oil, god grass oil, L- carvols, 1,8- cineoles, gaultherolin, Eugenol, thymol, linalool, limonene, menthones, menthyl acetate, citral, camphor, borneol, firpene, spilanthol In one or more.
7. according to claim 1 containing active Chinese drug component material and tea tree ethereal oil liquid oral composition, it is characterised in that The flocculant is modified chlorinated calcium, and the modified chlorinated calcium is grafted chitosan after acrylic acid cladding calcium chloride.
8. according to claim 7 containing active Chinese drug component material and tea tree ethereal oil liquid oral composition, it is characterised in that The percent grafting of the modified chlorinated calcium is 1～5%.
9. according to claim 8 containing active Chinese drug component material and tea tree ethereal oil liquid oral composition, it is characterised in that The percent grafting of the modified chlorinated calcium is 1～3%.
10. the preparation side containing active Chinese drug component material and tea tree ethereal oil liquid oral composition according to claims 1 to 9 Method, it is characterised in that comprise the following steps：

(1) Chinese medical extract, menthol, tea tree ethereal oil and water are added by weight, is stirred, be dissolved in the Chinese medical extract In water；

(2) additive being added by weight, being sufficiently stirred for, filtered, take filtrate, Jing sterilization processings obtain described containing Chinese medicine work Property material and tea tree ethereal oil liquid oral composition.