CN104887581A - Oral care composition and preparation method thereof - Google Patents
Oral care composition and preparation method thereof Download PDFInfo
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- CN104887581A CN104887581A CN201510325533.1A CN201510325533A CN104887581A CN 104887581 A CN104887581 A CN 104887581A CN 201510325533 A CN201510325533 A CN 201510325533A CN 104887581 A CN104887581 A CN 104887581A
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Abstract
The invention discloses an oral care composition and a preparation method thereof. The oral care composition comprises the following ingredients by weight percent: 14.35-99% of aloe gel liquor, 0.001-0.15% of B-vitamins, 0.001-5% of essential oil, 0.001-8% of an absorption promoter and 0.1-15% of a surfactant and a solubilizer. The preparation method comprises the following steps: adding the B-vitamins and water-soluble components in the absorption promoter into the aloe gel liquor, and uniformly stirring and mixing to obtain a mixed solution; emulsifying and solubilizing the essential oil and water-insoluble components in the absorption promoter by the surfactant and the solubilizer, then adding the emulsified and solubilized materials into the mixed solution, and stirring or homogenizing to obtain the oral care composition. The oral care composition can prevent, relieve and soothe various oral inflammations to promote healing of wound surfaces and accelerate restoration of oral mucosas. When the oral care composition remains for a longer time in the oral cavity, the utilization ratio can be improved and the effect taking time can be prolonged.
Description
Technical field
The present invention relates to a kind of oral care composition and preparation method thereof, particularly one has cleaning oral cavity, alleviates the multi-function oral care compositions of oral cavity, gingiva nonspecific inflammation symptom.
Background technology
Oral care product is in the market toothpaste, collutory mainly, and it is main mainly with basic nursings such as simple cleaning oral cavity or fresh breaths.Raising along with people's living standard and the continuous pursuit to U.S., oral health has become the focus that people pay close attention to, has occurred various effect type oral care product on the market.
Toothpaste needs to coordinate toothbrush, cup and clear water because of it in use, inconvenient especially when going out, and when there being wound surface in oral cavity, the stimulation of toothbrush also can increase the weight of pain and the deterioration of site of injury.Collutory carries as one, easy to use, the oral care product because of the toothbrush problem that rubs that the wound surface that brings worsens, the pain increased can not be brought, be more and more subject to liking of consumers in general, especially both effectiveness collutory.The both effectiveness collutory that can be used for improving oral problem at present mainly comprises two classes: the collutory that (1) is main component with single or that plurality of Chinese composition is composite extracting solution; (2) with the collutory that chemical antiinflammatory is main component.(1) class Traditional-Chinese-medicine-type collutory complex process, production cost is high, and color is dark, flavour of a drug weight, on the outward appearance of product and mouthfeel impact comparatively large, and likely can introduce a large amount of organic solvent in the leaching process of active ingredient of Chinese herbs, affect health.The collutory of (2) class chemical drugs dosage form, life-time service can cause the drug-fast problem of microorganism.
In addition, collutory in use, is normally contained in mouth, agitates two cheeks and lip, collutory is fully contacted with tooth, gingiva in oral cavity, and utilizes waterpower to rinse each position, oral cavity repeatedly, spue after 30 seconds ~ 1 minute.The time stopped in mouth because of collutory is shorter, there is effective ingredient draws less, the problem that utilization rate is low.
Summary of the invention
For increase collutory utilize the time, avoid the problems such as Chinese medicine ingredients mouthfeel is poor, chemical agent is harmful, the invention provides a kind of oral care composition and preparation method thereof, it makes simply, utilization rate of active components is high, safety is high, can cleaning oral cavity, alleviate the multi-function oral care compositions of oral cavity, gingiva nonspecific inflammation symptom.
The present invention is realized by following technical proposal: a kind of oral care composition, it is characterized in that the component comprising following masses percent:
Aloe gel juice 14.35 ~ 99%, vitamin B group 0.001 ~ 0.15%,
Quintessence oil 0.001 ~ 5%, absorption enhancer 0.001 ~ 8%,
Surfactant and solubilizing agent 0.1 ~ 15%.
Described Aloe gel juice obtains through the following step:
A, aloe leaf cleaned, remove the peel, squeeze the juice, sterilize, enzymolysis, plate-and-frame filtration obtain the Aloe juice that soluble solid is 0.5 ~ 1.25%;
B, volume ratio by Lu Hui juice ︰ macroporous anion exchange resin=20 ~ 25 ︰ 1, by steps A gained Aloe juice by macroporous anion exchange resin column, control 20 ~ 30min time of contact, namely obtains the Aloe glue juice removing anthraquinone, pigment;
C, with molecular cut off be 18 reverse osmosis membrane step B gained Aloe glue juice is concentrated, collect concentrated solution, namely obtain Aloe gel juice.
Described vitamin B group is one or more in vitamin B1, vitamin B2, vitamin B6, vitamin B12.
The derived essential oil that described quintessence oil comprises parent quintessence oil and separates from parent quintessence oil is one or more in thymol, cineole, methyl salicylate, menthol, tea tree ethereal oil, cinnamon essential oil, citral, clove seed quintessence oil, citronellol, fragrant Chinese holly leaf essential oil.
Described absorption enhancer is made up of taste stimulation agent, heat sensitizer and film former.
Described taste stimulation agent is one or more in Sal, phosphoric acid, organic food acids.
Described organic food acids is lactic acid or citric acid.
Described heat sensitizer is one or more in vanillyl alcohol n-butyl ether, zingiberol, vanillyl alcohol isobutyl ether, vanillyl alcohol n-propyl ether, vanillyl alcohol isopropyl base base ether, vanillyl alcohol n-amino ether, vanillyl alcohol methyl ether, vanillyl alcohol isoamyl ether, cephrol n-hexyl ether, vanillyl alcohol ethyl ether, shogaol, (4-hydroxy-3-methoxyphenyl)ethyl methyl ketone, capsaicin.
Described film former is one or more in sodium alginate, xanthan gum, carboxymethyl cellulose, hydroxy propyl cellulose, hydroxybutyl cellulose, Cellulose ethyl hydroxypropyl ether, methylethylcellulose, hydroxypropyl emthylcellulose, carrageenin, microcrystalline Cellulose, chitosan.
Further, the mass ratio of described taste stimulation agent, heat sensitizer and film former is (0.06 ~ 2): (0.001 ~ 1): (0.01 ~ 5).
The non-ionic surface active agent of described surfactant to be HLB value be the single of 8-18 or compound, comprise in TWEEN Series, Span series, castor oil hydrogenated, alkyl polyglucoside, cithrol one or more.
Described TWEEN Series is one or more in tween 20, Tween-60, tween 80.
Described Span series is one or more in Arlacel-20, Arlacel-60, Arlacel-80.
Described castor oil hydrogenated is one or both in Cremophor RH40, PEG-60 castor oil hydrogenated.
The alkyl polyglucoside of described alkyl polyglucoside to be atomic number of alkyl carbon be 10-14.
Described solubilizing agent is alcohols solubilizing agent, comprises one or more in propylene glycol, ethanol, butanediol, Polyethylene Glycol.
Further, described oral care composition also comprises water, accounts for 0 ~ 50% of oral care composition quality.
Further, described oral care composition also comprises natural antiinflammatory anti-allergic agent, as Flos Lonicerae extractive solution, white paeony root extract, Rhizoma Zingiberis Recens extracting solution, Radix Glycyrrhizae and derivant (as glycyrrhizic acid dipotassium) thereof etc.Account for 0 ~ 5% of oral care composition quality.
Further, in order to extend the resting period of oral care composition involved in the present invention, it also comprises appropriate antiseptic.Account for 0 ~ 1% of oral care composition quality.
Further, in order to improve the mouthfeel of oral care composition involved in the present invention, it also comprises appropriate sweeting agent, and sweeting agent is selected from least one in aspartame, saccharin sodium, xylitol.Account for 0 ~ 0.5% of oral care composition quality.
Further, oral care composition involved in the present invention also can comprise complementary composition, as pH adjusting agent, chelating agen, spice, antioxidant.Account for 0 ~ 1% of oral care composition quality.
Another object of the present invention is to the preparation method that a kind of oral care composition is provided, through following each step:
(1) by the component of following mass percent:
Aloe gel juice 14.35 ~ 99%, vitamin B group 0.001 ~ 0.15%,
Quintessence oil 0.001 ~ 5%, absorption enhancer 0.001 ~ 8%,
Surfactant and solubilizing agent 0.1 ~ 15%;
(2) vitamin B group in step (1) and the water soluble ingredient in absorption enhancer are added in Aloe gel juice, and be uniformly mixed and obtain mixed liquor;
(3) add in step (1) gained mixed liquor after the quintessence oil in step (1) and the water insoluble ingredients surfactant in absorption enhancer and solubilizing agent being carried out emulsifying solubilising, and stir or homogenizing, namely obtain oral care composition.
One or more in water, natural antiinflammatory anti-allergic agent, antiseptic, sweeting agent, complementary composition are added by demand after stirring in described step (3) or homogenizing.
The pharmacological action of oral care composition provided by the invention: the Aloe polysaccharide in Aloe gel juice can strengthen immune system, promote that tissue divots fiber increases, cell nutrients is provided, promotes cell metabolism, help cytothesis, thus promote wound healing in oral cavity, reparation oral mucosa.Vitamin B group can maintain the health of skin and muscle, promotes immune system and nervous system, Promote cell's growth and division.Quintessence oil has antimicrobial acivity, can suppress the formation of dental plaque and gingivitis.Three's synergism of Aloe gel juice, vitamin B group and quintessence oil, can effectively prevent and alleviate oral inflammation (as alleviating gingivitis, angular cheilitis, oral ulcer etc.), wound repairing, to ease the pain, accelerate the maintenance of oral mucosa, improve oral environment.Taste stimulation agent in absorption enhancer can stimulate the human body sense of taste, promotes salivation, maintains cavity interior moistening, is conducive to the osmotic absorption of active matter; Heat sensitizer when using this oral care composition to gargle to wash oral cavity, can provide warmth sensation at cavity interior, promoting microcirculation in oral cavity, promoting active ingredient draws.Both combineds effect, the use for this oral care composition provides a relatively damp and hot oral environment, to promote the quick absorption of its effective ingredient.Film former in absorption enhancer not only can improve the viscosity of oral care composition, increase it when rinsing the mouth and the time of contact of oral cavity wall, tongue and gingiva etc., and the temporary thin film of one deck can be formed in the oral cavity, strengthen active component adhesiveness in the oral cavity in oral care composition, extend the time of active ingredient exerts function.Three's combined effect in absorption enhancer, can improve the utilization rate of effective ingredient in this oral care composition, extends the time of its efficacy exertion, better protects the health of one's mouth to make it.In addition, the taste stimulation agent in absorption enhancer, can stimulate the human body sense of taste, promote salivation, make the self-cleaning of cavity interior, sterilizing function given full play to, other functional component combined effect with oral care composition, can recover oral health sooner, better.Surfactant and solubilizing agent are mainly used in the water insoluble ingredients in emulsifying, solubilising oral care composition, strengthen the effect of its cleaning oral cavity simultaneously.
The advantage that the present invention possesses and effect: oral care composition involved in the present invention makes simply, utilization rate of active components is high, can cleaning oral cavity, alleviate oral cavity, gingiva nonspecific inflammation symptom, Aloe gel juice contained by it, vitamin B group, quintessence oil combined effect are in oral cavity, can prevent, alleviate and alleviate all kinds of oral inflammation, promote the healing of wound surface, accelerate the maintenance of oral mucosa; Absorption enhancer contained by it can increase Aloe gel juice, vitamin B group, quintessence oil when rinsing the mouth and the adhesion of oral cavity wall, tongue etc., extends its time of staying in the oral cavity, improves its utilization rate, extend the time of its efficacy exertion.
Detailed description of the invention
Below by embodiment, the present invention is specifically described.
Embodiment 1
(1) component of according to the form below and content are got the raw materials ready:
| Component | Content % |
| Aloe gel juice | 55.00％ |
| Vitamin B1 | 0.02％ |
| Vitamin B2 | 0.01％ |
| Thymol | 0.10％ |
| Cineole | 0.002％ |
| Methyl salicylate | 0.01％ |
| Menthol | 0.01％ |
| Sal | 0.60％ |
| Vanillyl alcohol n-butyl ether | 0.01％ |
| Xanthan gum | 0.10％ |
| Tween 20 | 0.03％ |
| Polyethylene Glycol-12-hydroxy stearic acid | 2.50％ |
| Ethanol | 2.00％ |
| Water | 37.658％ |
| Glycyrrhizic acid dipotassium | 0.25％ |
| Antiseptic | 1％ |
| Xylitol | 0.2％ |
| PH adjusting agent | 0.5％ |
Wherein, Aloe gel juice obtains through the following step:
A, aloe leaf cleaned, remove the peel, squeeze the juice, sterilize, enzymolysis, plate-and-frame filtration obtain the Aloe juice that soluble solid is 1%;
B, volume ratio by Lu Hui juice ︰ macroporous anion exchange resin=25 ︰ 1, by steps A gained Aloe juice by macroporous anion exchange resin column, control 20min time of contact, namely obtains the Aloe glue juice removing anthraquinone, pigment;
C, with molecular cut off be 18 reverse osmosis membrane step B gained Aloe glue juice is concentrated, collect concentrated solution, namely obtain Aloe gel juice;
(2) vitamin B group in step (1) and the water soluble ingredient in absorption enhancer are added in Aloe gel juice, and be uniformly mixed and obtain mixed liquor;
(3) add in step (1) gained mixed liquor after the quintessence oil in step (1) and the water insoluble ingredients surfactant in absorption enhancer and solubilizing agent being carried out emulsifying solubilising, and stir or homogenizing, add water, natural antiinflammatory anti-allergic agent, antiseptic, sweeting agent, complementary composition again, namely obtain oral care composition.
Embodiment 2
(1) component of according to the form below and content are got the raw materials ready:
| Composition | Content % |
| Aloe gel juice | 82.77％ |
| Vitamin B1 | 0.01％ |
| Vitamin B2 | 0.01％ |
| Vitamin B12 | 0.005％ |
| Cinnamon essential oil | 0.25％ |
| Thymol | 0.20％ |
| Methyl salicylate | 0.005％ |
| Tea tree ethereal oil | 0.10％ |
| Sal | 0.40％ |
| Vanillyl alcohol n-butyl ether | 0.10％ |
| Sodium alginate | 0.25％ |
| Tween 20 | 0.40％ |
| Polyethylene Glycol-12-hydroxy stearic acid | 8.00％ |
| Ethanol | 5.00％ |
| Flos Lonicerae extractive solution | 0.50％ |
| Antiseptic | 0.50％ |
| Aspartame | 0.50％ |
| PH adjusting agent | 1％ |
Wherein, Aloe gel juice obtains through the following step:
A, aloe leaf cleaned, remove the peel, squeeze the juice, sterilize, enzymolysis, plate-and-frame filtration obtain the Aloe juice that soluble solid is 1.25%;
B, volume ratio by Lu Hui juice ︰ macroporous anion exchange resin=22 ︰ 1, by steps A gained Aloe juice by macroporous anion exchange resin column, control 25min time of contact, namely obtains the Aloe glue juice removing anthraquinone, pigment;
C, with molecular cut off be 18 reverse osmosis membrane step B gained Aloe glue juice is concentrated, collect concentrated solution, namely obtain Aloe gel juice;
(2) vitamin B group in step (1) and the water soluble ingredient in absorption enhancer are added in Aloe gel juice, and be uniformly mixed and obtain mixed liquor;
(3) add in step (1) gained mixed liquor after the quintessence oil in step (1) and the water insoluble ingredients surfactant in absorption enhancer and solubilizing agent being carried out emulsifying solubilising, and stir or homogenizing, add natural antiinflammatory anti-allergic agent, antiseptic, sweeting agent, complementary composition again, namely obtain oral care composition.
Embodiment 3
(1) component of according to the form below and content are got the raw materials ready:
| Composition | Content % |
| Aloe gel juice | 99％ |
| Vitamin B1 | 0.05％ |
| Vitamin B6 | 0.05％ |
| Citral | 0.13％ |
| Lactic acid | 0.1％ |
| Zingiberol | 0.02％ |
| Carboxymethyl cellulose | 0.1％ |
| Arlacel-20 | 0.05％ |
| Tween 20 | 0.35％ |
| Propylene glycol | 0.15％ |
Wherein, Aloe gel juice obtains through the following step:
A, aloe leaf cleaned, remove the peel, squeeze the juice, sterilize, enzymolysis, plate-and-frame filtration obtain the Aloe juice that soluble solid is 0.5%;
B, volume ratio by Lu Hui juice ︰ macroporous anion exchange resin=20 ︰ 1, by steps A gained Aloe juice by macroporous anion exchange resin column, control 30min time of contact, namely obtains the Aloe glue juice removing anthraquinone, pigment;
C, with molecular cut off be 18 reverse osmosis membrane step B gained Aloe glue juice is concentrated, collect concentrated solution, namely obtain Aloe gel juice;
(2) vitamin B group in step (1) and the water soluble ingredient in absorption enhancer are added in Aloe gel juice, and be uniformly mixed and obtain mixed liquor;
(3) add in step (1) gained mixed liquor after the quintessence oil in step (1) and the water insoluble ingredients surfactant in absorption enhancer and solubilizing agent being carried out emulsifying solubilising, and stir or homogenizing, namely obtain oral care composition.
Embodiment 4
(1) component of according to the form below and content are got the raw materials ready:
Wherein, Aloe gel juice obtains through the following step:
A, aloe leaf cleaned, remove the peel, squeeze the juice, sterilize, enzymolysis, plate-and-frame filtration obtain the Aloe juice that soluble solid is 1.25%;
B, volume ratio by Lu Hui juice ︰ macroporous anion exchange resin=22 ︰ 1, by steps A gained Aloe juice by macroporous anion exchange resin column, control 25min time of contact, namely obtains the Aloe glue juice removing anthraquinone, pigment;
C, with molecular cut off be 18 reverse osmosis membrane step B gained Aloe glue juice is concentrated, collect concentrated solution, namely obtain Aloe gel juice;
(2) vitamin B group in step (1) and the water soluble ingredient in absorption enhancer are added in Aloe gel juice, and be uniformly mixed and obtain mixed liquor;
(3) add in step (1) gained mixed liquor after the quintessence oil in step (1) and the water insoluble ingredients surfactant in absorption enhancer and solubilizing agent being carried out emulsifying solubilising, and stir or homogenizing, add water, natural antiinflammatory anti-allergic agent, antiseptic, sweeting agent, complementary composition again, namely obtain oral care composition.
Embodiment 5
(1) component of according to the form below and content are got the raw materials ready:
| Component | Content % |
| Aloe gel juice | 72.609％ |
| Vitamin B2 | 0.001％ |
| Thymol | 0.08％ |
| Phosphoric acid | 0.1％ |
| (4-hydroxy-3-methoxyphenyl)ethyl methyl ketone | 0.0003％ |
| Methylethylcellulose | 0.03％ |
| Chitosan | 0.02％ |
| PEG-60 castor oil hydrogenated | 0.03％ |
| Cithrol | 2.50％ |
| Ethanol | 2.00％ |
| Water | 20.9297％ |
| Glycyrrhizic acid dipotassium | 0.8％ |
| Antiseptic | 0.3％ |
| Xylitol | 0.2％ |
| Spice | 0.2％ |
| Antioxidant | 0.2％ |
Wherein, Aloe gel juice obtains through the following step:
A, aloe leaf cleaned, remove the peel, squeeze the juice, sterilize, enzymolysis, plate-and-frame filtration obtain the Aloe juice that soluble solid is 1%;
B, volume ratio by Lu Hui juice ︰ macroporous anion exchange resin=25 ︰ 1, by steps A gained Aloe juice by macroporous anion exchange resin column, control 20min time of contact, namely obtains the Aloe glue juice removing anthraquinone, pigment;
C, with molecular cut off be 18 reverse osmosis membrane step B gained Aloe glue juice is concentrated, collect concentrated solution, namely obtain Aloe gel juice;
(2) vitamin B group in step (1) and the water soluble ingredient in absorption enhancer are added in Aloe gel juice, and be uniformly mixed and obtain mixed liquor;
(3) add in step (1) gained mixed liquor after the quintessence oil in step (1) and the water insoluble ingredients surfactant in absorption enhancer and solubilizing agent being carried out emulsifying solubilising, and stir or homogenizing, add water, natural antiinflammatory anti-allergic agent, antiseptic, sweeting agent, complementary composition again, namely obtain oral care composition.
In addition, those skilled in the art also can make various amendments in other form and details, interpolation and replacement in the claims in the present invention scope of disclosure and spirit.Certainly, the changes such as these various amendments made according to the present invention's spirit, interpolation and replacement, all should be included within the present invention's scope required for protection.
Comparative example 1: the collutory being main component with the extracting solution that Chinese medicine ingredients is composite, Chinese medicine ingredients is mainly Herba Menthae, Flos Lonicerae, Flos Chrysanthemi.
Comparative example 2: the collutory being main component with chemical antiinflammatory, this antiinflammatory mainly contains metronidazole, hydrogen peroxide composition.
The clinical observation of the various embodiments described above gained oral care composition prevention and therapy oral disease:
One, patient's grouping: by the 120 routine patients meeting inclusive criteria, random point 3 groups, wherein the first treatment group 40 example, wherein man 20 example, female 20 example, 9 ~ 70 years old age; Second treatment group 40 example, wherein man 20 example, female 20 example, 9 ~ 70 years old age.Matched group 40 example, wherein man 20 example, female 20 example; 9 ~ 70 years old age.Three groups of ages, sex, the course of disease and cardinal symptoms are through statistical procedures, and no significant difference (P>0.05), has comparability.
Inclusive criteria: (1) all kinds of oral inflammation; (2) halitosis person.
Two, Therapeutic Method
Treatment group: the oral care composition 5-20ml of gained in Example 1-5, rinsing the mouth, after 30 seconds-5 minutes, spues.Can use 1-5 time every day according to actual needs.
First matched group: get commercial products 5-20ml selected by comparative example 1, rinsing the mouth, after 30 seconds-5 minutes, spues.Can use 1-5 time every day according to actual needs.
Second matched group: get commercial products 5-20ml selected by comparative example 2, rinsing the mouth, after 30 seconds-5 minutes, spues.Can use 1-5 time every day according to actual needs.
Four, result
Treatment group is 95% to the effective percentage of all kinds of oral inflammation, is 99% to the effective percentage of halitosis person.
First matched group is 60% to the effective percentage of all kinds of oral inflammation, is 79% to the effective percentage of halitosis person.
Second matched group is 82% to the effective percentage of all kinds of oral inflammation, is 31% to the effective percentage of halitosis person.
Analyze through Ridit, P<0.05, treatment group is better than matched group.
Five, conclusion
Oral care composition therapeutical effect provided by the invention is better than matched group, and simply, safely, have no side effect, no pain, be the convenient Therapeutic Method of all kinds of common oral of prevention and therapy disease.
In sum, oral care composition provided by the invention promotes the healing of wound surface, accelerates effect of the maintenance of oral mucosa, cleaning oral cavity, alleviate oral cavity, gingiva nonspecific inflammation symptom, extend its time of staying in the oral cavity, improve its utilization rate, extend the time of its efficacy exertion.There is good antiinflammatory, analgesia, cleaning action, oral mucosa reparation, fresh breath can be promoted, to gingivitis, oral ulcer, halitosis, oral lichen planus, there is good prevention and therapy effect, the object keeping oral health can be reached.Without any side effects, and mouthfeel is good, is applicable to life-time service, avoid traditional collutory flavour of a drug and weigh, introduce a large amount of organic solvent, affect health, life-time service can cause the problems such as the Drug resistance of microorganism, and safely, effectively.
Lower attached model case:
1, certain female, 32 years old.Suffers from gingival swelling and pain.The oral care composition rinsing the mouth of each use embodiment 1, after about 30 seconds, spues.Every day rinsing the mouth 3 times.Use after 2 days, feel that gingival swelling and pain is alleviated to some extent, continue oral care composition rinsing the mouth 1-2 time using embodiment 1 afterwards every day, the sensation gingival swelling and pain elimination afterwards that uses 5 days.
2, certain man, 53 years old.Suffer from oral ulcer, oral ulcer is positioned at lower lip and the tip of the tongue, and about have soybean grain large, have obvious pain when drinking water and have a meal, oral ulcer continues 3 days.After just having started to use the oral care composition rinsing the mouth of embodiment 2 to be about 1-2min, spued at every turn.Every day rinsing the mouth 5 times.Feels pain sense after 4 days is used obviously to improve.Continue oral care composition rinsing the mouth 1-3 time using embodiment 2 afterwards every day, use oral ulcer disappearance after 1 month.
3, certain female, 45 years old.Suffer from oral lichen planus, tongue has and slightly festers.After the oral care composition rinsing the mouth of each use embodiment 2 is about 3-5min, spue.Every day rinsing the mouth 5 times.Use feels pain sense after 4 days obviously to improve, after using 6 months continuously, symptom disappears substantially.
4, certain man, 36 years old.Suffer from oral ulcer, there is abnormal flavour in oral cavity, and oral ulcer is positioned at Sublingual, about has the grain of rice large, with pain.After the oral care composition rinsing the mouth 1min of each use embodiment 1, spue.Every day rinsing the mouth 3 times.Use after 5 days, pain is obviously improved, and use oral ulcer after 1 month substantially to eliminate, and halitosis makes moderate progress, and after using 6 weeks continuously, halitosis is eliminated substantially.
Claims (10)
1. an oral care composition, is characterized in that the component comprising following masses percent:
Aloe gel juice 14.35 ~ 99%, vitamin B group 0.001 ~ 0.15%,
Quintessence oil 0.001 ~ 5%, absorption enhancer 0.001 ~ 8%,
Surfactant and solubilizing agent 0.1 ~ 15%.
2. oral care composition according to claim 1, is characterized in that: described Aloe gel juice obtains through the following step:
A, aloe leaf cleaned, remove the peel, squeeze the juice, sterilize, enzymolysis, plate-and-frame filtration obtain the Aloe juice that soluble solid is 0.5 ~ 1.25%;
B, volume ratio by Lu Hui juice ︰ macroporous anion exchange resin=20 ~ 25 ︰ 1, by steps A gained Aloe juice by macroporous anion exchange resin column, control 20 ~ 30min time of contact, namely obtains the Aloe glue juice removing anthraquinone, pigment;
C, with molecular cut off be 18 reverse osmosis membrane step B gained Aloe glue juice is concentrated, collect concentrated solution, namely obtain Aloe gel juice.
3. oral care composition according to claim 1, is characterized in that: described vitamin B group is one or more in vitamin B1, vitamin B2, vitamin B6, vitamin B12.
4. oral care composition according to claim 1, it is characterized in that: the derived essential oil that described quintessence oil comprises parent quintessence oil and separates from parent quintessence oil, is one or more in thymol, cineole, methyl salicylate, menthol, tea tree ethereal oil, cinnamon essential oil, citral, clove seed quintessence oil, citronellol, fragrant Chinese holly leaf essential oil.
5. oral care composition according to claim 1, is characterized in that: described absorption enhancer is made up of taste stimulation agent, heat sensitizer and film former; Described taste stimulation agent is one or more in Sal, phosphoric acid, organic food acids, and wherein organic food acids is lactic acid or citric acid; Described heat sensitizer is one or more in vanillyl alcohol n-butyl ether, zingiberol, vanillyl alcohol isobutyl ether, vanillyl alcohol n-propyl ether, vanillyl alcohol isopropyl base base ether, vanillyl alcohol n-amino ether, vanillyl alcohol methyl ether, vanillyl alcohol isoamyl ether, cephrol n-hexyl ether, vanillyl alcohol ethyl ether, shogaol, (4-hydroxy-3-methoxyphenyl)ethyl methyl ketone, capsaicin; Described film former is one or more in sodium alginate, xanthan gum, carboxymethyl cellulose, hydroxy propyl cellulose, hydroxybutyl cellulose, Cellulose ethyl hydroxypropyl ether, methylethylcellulose, hydroxypropyl emthylcellulose, carrageenin, microcrystalline Cellulose, chitosan; The mass ratio of described taste stimulation agent, heat sensitizer and film former is (0.06 ~ 2): (0.001 ~ 1): (0.01 ~ 5).
6. oral care composition according to claim 1, it is characterized in that: the non-ionic surface active agent of described surfactant to be HLB value be the single of 8-18 or compound, comprise in TWEEN Series, Span series, castor oil hydrogenated, alkyl polyglucoside, cithrol one or more; Wherein TWEEN Series is one or more in tween 20, Tween-60, tween 80; Span series is one or more in Arlacel-20, Arlacel-60, Arlacel-80; Castor oil hydrogenated is one or both in Cremophor RH40, PEG-60 castor oil hydrogenated; The alkyl polyglucoside of alkyl polyglucoside to be atomic number of alkyl carbon be 10-14.
7. oral care composition according to claim 1, is characterized in that: described solubilizing agent is alcohols solubilizing agent, comprises one or more in propylene glycol, ethanol, butanediol, Polyethylene Glycol.
8. oral care composition according to claim 1, is characterized in that: described oral care composition also comprises water, accounts for 0 ~ 50% of oral care composition quality; Described oral care composition also comprises natural antiinflammatory anti-allergic agent, accounts for 0 ~ 5% of oral care composition quality; Described oral care composition also comprises antiseptic, accounts for 0 ~ 1% of oral care composition quality; Described oral care composition also comprises sweeting agent, and sweeting agent is selected from least one in aspartame, saccharin sodium, xylitol, accounts for 0 ~ 0.5% of oral care composition quality; Described oral care composition also comprises complementary composition, accounts for 0 ~ 1% of oral care composition quality.
9. a preparation method for oral care composition, is characterized in that through following each step:
(1) by the component of following mass percent:
Aloe gel juice 14.35 ~ 99%, vitamin B group 0.001 ~ 0.15%,
Quintessence oil 0.001 ~ 5%, absorption enhancer 0.001 ~ 8%,
Surfactant and solubilizing agent 0.1 ~ 15%;
(2) vitamin B group in step (1) and the water soluble ingredient in absorption enhancer are added in Aloe gel juice, and be uniformly mixed and obtain mixed liquor;
(3) add in step (1) gained mixed liquor after the quintessence oil in step (1) and the water insoluble ingredients surfactant in absorption enhancer and solubilizing agent being carried out emulsifying solubilising, and stir or homogenizing, namely obtain oral care composition.
10. preparation method according to claim 9, is characterized in that: add one or more in water, natural antiinflammatory anti-allergic agent, antiseptic, sweeting agent, complementary composition by demand after the stirring in described step (3) or homogenizing.
Priority Applications (1)
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Cited By (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105168927A (en) * | 2015-09-24 | 2015-12-23 | 王栩 | Medicine and atomized liquid for treating oral lichen planus and preparation method |
| CN105456132A (en) * | 2015-12-28 | 2016-04-06 | 肇庆迪彩日化科技有限公司 | Composition of plant extracts and application of composition |
| CN105726408A (en) * | 2016-03-28 | 2016-07-06 | 北京世纪鸿成商贸有限公司 | Tooth gel |
| CN106177269A (en) * | 2016-07-07 | 2016-12-07 | 万苏晨 | The pharmaceutical composition of quick curing oral keritonocytes, preparation method and application |
| CN106265384A (en) * | 2016-10-14 | 2017-01-04 | 柳州环山科技有限公司 | A kind of anemia of pregnant woman's collutory and preparation method thereof |
| CN106265383A (en) * | 2016-10-14 | 2017-01-04 | 柳州环山科技有限公司 | A kind of child's collutory and preparation method thereof |
| CN106562921A (en) * | 2016-11-02 | 2017-04-19 | 李浩然 | Liquid oral composition containing TCM active substances and tea tree essential oil |
| CN107375024A (en) * | 2017-07-04 | 2017-11-24 | 广东丸美生物技术股份有限公司 | One kind stablizes a phase solubilization method |
| CN107595750A (en) * | 2017-07-28 | 2018-01-19 | Dj健康产业集团 | A kind of active inflammation-diminishing toothpaste |
| CN108096486A (en) * | 2018-01-25 | 2018-06-01 | 北京斯利安药业有限公司 | Composition, pelliculae pro cavo oris and preparation method thereof |
| CN108379432A (en) * | 2018-04-18 | 2018-08-10 | 佛山科学技术学院 | It is a kind of to be used to treat gel of various focusing depths represented and preparation method thereof |
| CN109511966A (en) * | 2017-09-20 | 2019-03-26 | 吉奥菲特有限责任公司 | Food composition for antitumor therapy |
| CN111000871A (en) * | 2020-01-18 | 2020-04-14 | 杭州倍荣生物科技有限公司 | Oral cavity spray and preparation method thereof |
| CN111166711A (en) * | 2020-03-05 | 2020-05-19 | 珠海市尼诺生物科技有限公司 | Sterilizing mouthwash |
| CN111467365A (en) * | 2019-01-24 | 2020-07-31 | 开封九福来生物技术有限公司 | Oral instant film agent containing dendrobium polysaccharide and preparation method thereof |
| CN111728905A (en) * | 2020-06-02 | 2020-10-02 | 福州安得尔卫生技术开发有限公司 | Plant gargle |
| CN112694622A (en) * | 2020-12-29 | 2021-04-23 | 山东爱维德生物科技有限公司 | Temperature-sensitive aloe arborescens-chitosan-poly (N-isopropylacrylamide) gel |
| CN114652647A (en) * | 2022-02-14 | 2022-06-24 | 西安医学院 | Mouthwash for preventing decayed teeth and preparation method thereof |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1297735A (en) * | 1999-12-02 | 2001-06-06 | 马贵龄 | Aloe toothpaste |
| CN1857197A (en) * | 2006-03-10 | 2006-11-08 | 贵州宏宇药业有限公司 | Oral cavity cleaning bacteriostat and its preparing process |
| CN101249056A (en) * | 2008-01-11 | 2008-08-27 | 美晨集团股份有限公司 | Anti-inflammation gargle water and method of preparing the same |
| CN103140209A (en) * | 2010-10-01 | 2013-06-05 | 宝洁公司 | Oral care compositions with improved flavor |
| CN104693314A (en) * | 2015-03-16 | 2015-06-10 | 云南万绿生物股份有限公司 | Processing method for 2000: 1 aloe gel dry powder |
-
2015
- 2015-06-11 CN CN201510325533.1A patent/CN104887581B/en active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1297735A (en) * | 1999-12-02 | 2001-06-06 | 马贵龄 | Aloe toothpaste |
| CN1857197A (en) * | 2006-03-10 | 2006-11-08 | 贵州宏宇药业有限公司 | Oral cavity cleaning bacteriostat and its preparing process |
| CN101249056A (en) * | 2008-01-11 | 2008-08-27 | 美晨集团股份有限公司 | Anti-inflammation gargle water and method of preparing the same |
| CN103140209A (en) * | 2010-10-01 | 2013-06-05 | 宝洁公司 | Oral care compositions with improved flavor |
| CN104693314A (en) * | 2015-03-16 | 2015-06-10 | 云南万绿生物股份有限公司 | Processing method for 2000: 1 aloe gel dry powder |
Non-Patent Citations (2)
| Title |
|---|
| 于康: "《吃好比好吃更重要2—于康谈怎么吃最健康》", 28 February 2013, 江苏科学技术出版社 * |
| 陈杏云等: "《芦荟治百病（第3版）》", 30 September 2014, 上海科学技术文献出版社 * |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105168927A (en) * | 2015-09-24 | 2015-12-23 | 王栩 | Medicine and atomized liquid for treating oral lichen planus and preparation method |
| CN105456132A (en) * | 2015-12-28 | 2016-04-06 | 肇庆迪彩日化科技有限公司 | Composition of plant extracts and application of composition |
| CN105726408A (en) * | 2016-03-28 | 2016-07-06 | 北京世纪鸿成商贸有限公司 | Tooth gel |
| CN106177269A (en) * | 2016-07-07 | 2016-12-07 | 万苏晨 | The pharmaceutical composition of quick curing oral keritonocytes, preparation method and application |
| CN106265384A (en) * | 2016-10-14 | 2017-01-04 | 柳州环山科技有限公司 | A kind of anemia of pregnant woman's collutory and preparation method thereof |
| CN106265383A (en) * | 2016-10-14 | 2017-01-04 | 柳州环山科技有限公司 | A kind of child's collutory and preparation method thereof |
| CN106562921A (en) * | 2016-11-02 | 2017-04-19 | 李浩然 | Liquid oral composition containing TCM active substances and tea tree essential oil |
| CN107375024A (en) * | 2017-07-04 | 2017-11-24 | 广东丸美生物技术股份有限公司 | One kind stablizes a phase solubilization method |
| CN107595750A (en) * | 2017-07-28 | 2018-01-19 | Dj健康产业集团 | A kind of active inflammation-diminishing toothpaste |
| CN107595750B (en) * | 2017-07-28 | 2020-07-14 | Dj健康产业集团 | Active anti-inflammation toothpaste |
| CN109511966A (en) * | 2017-09-20 | 2019-03-26 | 吉奥菲特有限责任公司 | Food composition for antitumor therapy |
| CN108096486A (en) * | 2018-01-25 | 2018-06-01 | 北京斯利安药业有限公司 | Composition, pelliculae pro cavo oris and preparation method thereof |
| CN108379432A (en) * | 2018-04-18 | 2018-08-10 | 佛山科学技术学院 | It is a kind of to be used to treat gel of various focusing depths represented and preparation method thereof |
| CN111467365A (en) * | 2019-01-24 | 2020-07-31 | 开封九福来生物技术有限公司 | Oral instant film agent containing dendrobium polysaccharide and preparation method thereof |
| CN111000871A (en) * | 2020-01-18 | 2020-04-14 | 杭州倍荣生物科技有限公司 | Oral cavity spray and preparation method thereof |
| CN111166711A (en) * | 2020-03-05 | 2020-05-19 | 珠海市尼诺生物科技有限公司 | Sterilizing mouthwash |
| CN111728905A (en) * | 2020-06-02 | 2020-10-02 | 福州安得尔卫生技术开发有限公司 | Plant gargle |
| CN112694622A (en) * | 2020-12-29 | 2021-04-23 | 山东爱维德生物科技有限公司 | Temperature-sensitive aloe arborescens-chitosan-poly (N-isopropylacrylamide) gel |
| CN114652647A (en) * | 2022-02-14 | 2022-06-24 | 西安医学院 | Mouthwash for preventing decayed teeth and preparation method thereof |
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