CN1857197A - Oral cavity cleaning bacteriostat and its preparing process - Google Patents
Oral cavity cleaning bacteriostat and its preparing process Download PDFInfo
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- CN1857197A CN1857197A CN 200610200223 CN200610200223A CN1857197A CN 1857197 A CN1857197 A CN 1857197A CN 200610200223 CN200610200223 CN 200610200223 CN 200610200223 A CN200610200223 A CN 200610200223A CN 1857197 A CN1857197 A CN 1857197A
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Abstract
The present invention discloses a kind of oral cavity cleaning bacteriostat and its preparation process. The oral cavity cleaning bacteriostat consists of blumea oil 5-25 weight portions, mint oil 1-15 weight portions, assistant I 170-210 weight portions, assistant II 20-40 weight portions, inorganic salt 10-30 weight portions, preservative 1-5 weight portions, surfactant 27-55 weight portions, pigment 1-10 weight portions, edible alcohol 60-100 weight portions, and distilled water 500-800 weight portions. The assistant I consists of sorbitol and 1, 2-propylene glycol or glycerin in the weight ratio of 1 to 2-3, and the assistant II is sodium carboxymethyl cellulolse or sodium carboxyethyl cellulolse. The oral cavity cleaning bacteriostat has the functions of both toothpaste and gargle.
Description
Technical field
The present invention relates to a kind of cleaning bacteriostat and preparation method thereof, particularly a kind of cleaning bacteriostat that is used for the oral cavity and preparation method thereof.
Background technology
Oral care implement is the important component part of personal-care supplies, and is closely bound up with people's lives.At present, the oral care implement that people generally use is a toothpaste, but toothpaste can not use separately, need to cooperate toothbrush, cup and clear water, it is not very convenient using, therefore people can not clean the oral cavity after going out to have meal timely, and this is for oral hygiene and collutory can not be equipped with toothbrush and uses.Along with the continuous quickening of people life, work rhythm, more and more higher to the requirement of mouth care, should nursing efficacy well convenient and swift again, traditional toothpaste more and more incompatibility people needs.
Summary of the invention
The object of the present invention is to provide a kind of oral cavity cleaning bacteriostat and preparation method thereof, solve the problem that prior art exists.
Technical scheme of the present invention.Oral cavity cleaning bacteriostat is characterized in that: this antibacterial is to make with the following weight parts proportion raw material: 5～25 parts of natural botanical extraction liquids, 1～15 part of Oleum menthae, 170～210 parts of auxiliary agent 1 components, 20～40 parts of auxiliary agent 2 components, 10～30 parts of inorganic salts, 1～5 part of antiseptic, 27～55 parts in surfactant, 1～10 part of pigment, 60～100 parts of edible ethanols, 500～800 parts of distilled water; Wherein: natural botanical extraction liquid is a Herba Blumeae Balsamiferae wet goods natural botanical extraction liquid, and auxiliary agent 1 component is 1: 2～3 by the weight ratio of sorbitol and 1,2 propylene glycol or glycerol formation, and auxiliary agent 2 components are made of carboxymethyl cellulose or sodium hydroxyethlcellulose.
In the above-mentioned oral cavity cleaning bacteriostat, inorganic salt can be with sodium bicarbonate or sodium carbonate; Antiseptic can be used the mixture of sodium benzoate or methyl parahydroxybenzoate and ethylparaben; Surfactant can be made of for 5～15 parts 20～30 parts of sodium lauryl sulphates, 2～10 parts of tween 20s, Arlacel-80.
Aforesaid oral cavity cleaning bacteriostat is to be made by the raw material of following weight parts preferably; 7.5～12.5 parts of Oleum Blumeae Balsamiferaes, 2.5～6.5 parts of Oleum menthae, 53～58 parts of sorbitol, 130～148 parts of 1,2 propylene glycol or glycerol, 25～35 parts of sodium carboxymethyl cellulose or sodium hydroxyethlcelluloses, 15～25 parts of sodium bicarbonate or sodium carbonate, 1.5～3.5 parts in the mixture of sodium benzoate or methyl parahydroxybenzoate and ethylparaben, 22.5～27.5 parts of sodium lauryl sulphates, 2.5～6.5 parts of tween 20s, 7.5～12.5 parts of Arlacel-80s, green 3.5～7.5 parts of food coloring light blue or food coloring Huang or food coloring, 75～95 parts of edible ethanols, 580～750 parts of distilled water.
Aforesaid oral cavity cleaning bacteriostat is to be made by the raw material of following weight parts better; 10 parts of Oleum Blumeae Balsamiferaes, 5 parts of Oleum menthae, 56 parts of sorbitol, 144 parts of glycerol, 30 parts of sodium carboxymethyl cellulose, 20 parts of sodium bicarbonate, 2 parts of sodium benzoate, 25 parts of sodium lauryl sulphates, 5 parts of tween 20s, 10 parts of Arlacel-80s, 4 parts of food coloring light blues (5% solution), 80 parts of edible ethanols, 609 parts of distilled water.
The preparation method of aforesaid oral cavity cleaning bacteriostat is characterized in that: by following step preparation;
A, with the mixture of sodium bicarbonate or sodium carbonate, sodium benzoate or methyl parahydroxybenzoate and ethylparaben, add in the distilled water of 1/2nd prescription total amounts, mix homogeneously, the distilled water that adds food coloring light blue or food coloring Huang or food coloring green solution and 1/3rd prescription total amounts again, after stirring, get solution A;
B, first with 1,2 propylene glycol or glycerol, sorbitol, sodium carboxymethyl cellulose or sodium hydroxyethlcellulose mix homogeneously, and, get solution B with its slow adding in the solution A under stirring;
C, the Oleum menthae and the Oleum Blumeae Balsamiferae of recipe quantity is dissolved in recipe quantity ethanol in, add in the solution B mixing behind the mix homogeneously, the distilled water that adds surplus adds sodium lauryl sulphate, tween 20, the Arlacel-80 of recipe quantity, mix homogeneously again, fill gets product.
The applicant has carried out a series of experiment, with the simple possible that proves that preparation of the present invention is effective, controlled, produce.
Experimental example 1, select Oleum Blumeae Balsamiferae, Oleum menthae, sorbitol, 1 for use, the mixture of 2 propylene glycol or glycerol, sodium bicarbonate or sodium carbonate, sodium carboxymethyl cellulose or sodium hydroxyethlcellulose, food coloring (5% solution), sodium benzoate or methyl parahydroxybenzoate and ethylparaben, sodium lauryl sulphate, tween 20, Arlacel-80 etc. are prepared burden each prescription of intuitive analysis to the influence of this quality, have found out best ratio.The oral cavity cleaning bacteriostat of making according to different proportional quantities in the content persistent period of extruding after the fill and the deployment conditions after spraying into the oral cavity carry out comprehensive grading.According to two aspect concrete condition reviews.
| The supplementary material title | Addition (umber) | ||||||
| 1 | 2 | 3 | 4 | 5 | |||
| Natural botanical extraction liquid | Oleum Blumeae Balsamiferae | 5 | 7.5 | 10 | 12.5 | 25 | |
| Oleum menthae | 1 | 2.5 | 5 | 6.5 | 15 | ||
| Auxiliary agent 1 | Sorbitol | 50 | 55 | 56 | 58 | 60 | |
| Glycerol or 1,2 propylene glycol | 120 | 130 | 144 | 148 | 150 | ||
| Auxiliary agent 2 | Sodium carboxymethyl cellulose or sodium hydroxyethlcellulose | 20 | 25 | 30 | 35 | 40 | |
| Inorganic salt | Sodium bicarbonate or sodium carbonate | 10 | 15 | 20 | 25 | 30 | |
| Antiseptic | The mixture of sodium benzoate or methyl parahydroxybenzoate and ethylparaben | 1 | 1.5 | 2 | 3.5 | 5 | |
| Surfactant | Sodium lauryl sulphate | 20 | 22.5 | 25 | 27.5 | 30 |
| Tween 20 | 2 | 2.5 | 5 | 6.5 | 10 | |
| Arlacel-80 | 5 | 7.5 | 10 | 12.5 | 15 | |
| Pigment (5% solution) | The food coloring light blue | 1 | 3.5 | 4 | 7.5 | 10 |
| Or food coloring Huang | 1 | 3.5 | 4 | 7.5 | 10 | |
| Or food coloring is green | 1 | 3.5 | 4 | 7.5 | 10 | |
| Edible ethanol | 60 | 75 | 80 | 95 | 100 | |
| Distilled water | 500 | 580 | 609 | 750 | 800 | |
| Overall merit | Generally | Better | Best | Better | Generally | |
Experiment shows: the resultant effect of product was best when 609 parts of 10 parts of Oleum Blumeae Balsamiferaes, 5 parts of Oleum menthae, 56 parts of sorbitol, 144 parts of glycerol, 30 parts of sodium carboxymethyl cellulose, 20 parts of sodium bicarbonate, 2 parts of sodium benzoate, 25 parts of sodium lauryl sulphates, 5 parts of tween 20s, 10 parts of Arlacel-80s, 4 parts of food coloring light blues (5% solution), 80 parts of edible ethanols, distilled water were filled a prescription.
Experimental example 2, the oral cavity cleaning bacteriostat bacteriostatic test:
Experiment shows: under 20 ± 2 ℃ condition, dilution in 1: 3, the oral bacteriostasis cleaning agent is to staphylococcus aureus, escherichia coli effect 1min, and average bacteriostasis rate all reaches 100.00% (100.00%); To Candida albicans effect 1min, average bacteriostasis rate all reaches 73.34% (69.48%～76.52%).According to GB15979-2002 " disposable use hygienic article sanitary standard ", think 1: 3 the dilution, the oral bacteriostasis cleaning agent has stronger inhibitory action to staphylococcus aureus and escherichia coli, and is inhibited to Candida albicans.
Experimental example 3, acute oral toxicity test.
Experiment is by " disinfection technology standard " (version in 2002) 2.3.1 standard.By following experimental technique: (1) contamination approach: once irritate stomach; (2) dosage grouping:, press 20 mices of the disposable filling stomach of 6000mg/kg BW (♀ ♂ half and half) dosage 0.4ml/20g again by 20000,10000, after 5000mg/kg BW carries out trial test; (3) the general situation of animal is observed in the contamination back, and poisoning symptom and death condition are observed 14 days time limits, with median lethal dose(LD 50) (LD
50) determine the acute toxicity classification.
Experimental result shows: oral cavity cleaning bacteriostat is to white mice acute oral median lethal dose(LD 50) (LD
50) greater than the 5000mg/kg body weight, true border is nontoxic.
Experimental example 4, eye irritant test;
Experiment is by " disinfection technology standard " (version in 2002) 2.3.4 bar standard.By following experimental technique: get and tried thing oral cavity cleaning bacteriostat stock solution 0.1ml and insert in the rabbit one side conjunctival sac, use normal saline flushing behind passive closed 4s, the 30s.Opposite side is made normal control with normal saline, the damage and the recovery situation of 1h, 24h, 48h, 72h, 7d, 14d, 21d perusal man lagophthalmos conjunctiva, iris and cornea behind eye drip.Change with 2% Fluress, lens examination cornea and iris.Carry out eye infringement grade scale integration and the evaluation of eye stimulus intensity by the regulation of disinfection technology standard.
Experimental result shows: the oral cavity cleaning microbial inoculum belongs to subexcite to New Zealand's every average score of lagophthalmos irritant reaction.
Experimental example 5, the skin irritation test;
Experiment is by " disinfection technology standard " (version in 2002) 2.3.3 bar standard.By following experimental technique: in 24 hours early stages of (1) experiment, tame rabbit back spinal column diamond wool is cut the left and right about 3cm * 3cm of unhairing scope; (2) experiment the time is applied to oral cavity cleaning bacteriostat stock solution 0.5ml on 2.5cm * 2.5cm 2 floor gauze and applies ointment or plaster at a side unhairing district skin surface, covers with the non-stimulated plastic sheeting of one deck then, and non-stimulated adhesive plaster of reuse and binder are fixed.Apply after 4 hours, remove the residual thing that tried with distilled water, opposite side unhairing district skin is as blank; (3) remove and tried behind the thing 1,24,48 hour, observe dermoreaction respectively, carry out dermoreaction, integration and stimulus intensity evaluation by the regulation of " sterilization and sterilization experimental technique standard ".
Experimental result shows: oral cavity cleaning bacteriostat is 0.33 to the highest stimulation index of new zealand rabbit skin irritation reaction, belongs to nonirritant.
Experimental example 6, the skin allergic reaction test;
Experiment is by " disinfection technology standard " (version in 2002) 2.3.6 bar standard.By following experimental technique: (1) experimental group: 24 hours early stages of experiment, with cropping in guinea pig back left of spine 3cm * 3cm scope, during experiment oral cavity cleaning bacteriostat stock solution 0.5ml is coated on the two-layer gauze of 2cm * 2cm, and it is applied ointment or plaster in left side unhairing district, cover with non-stimulated plastic sheeting, again with non-stimulated immobilization with adhesive tape.After continuing 6h, the 7th day and the 14th day in kind repeats once.Last was induced back 14 days, oral cavity cleaning bacteriostat stock solution 0.5ml is coated on the two-layer gauze of 2.0cm * 2.0cm, be applied to guinea pig back right side 3cm * 3cm unhairing district, cover with the non-stimulated plastic sheeting of one deck, again with non-stimulated immobilization with adhesive tape, to apply ointment or plaster behind the 6h and be tried the thing flush away, observe dermoreaction behind 24h and the 48h.
(2) positive controls: the same experimental group of experimental technique, inducer are 2, the 4-dinitrochlorobenzene, and induced concentration 4% excites concentration 1.2%.
(3) negative control group: in last induce excited in back 14 days the contact tried thing, exciting concentration is oral cavity cleaning bacteriostat stock solution.
Experimental result shows: oral cavity cleaning bacteriostat stock solution is 0% to guinea pig skin sensitization rate, does not see skin allergic reaction.
Experimental example 7, the test of mouse bone marrow cells polychromatophilia micronucleus in erythrocytes;
Experiment is by " disinfection technology standard " (version in 2002) 2.3.8.4 bar standard.By following experimental technique: select 50 healthy mices for use, divide 5 groups at random, every group female, male each 5, establish three dosage groups altogether, the dosage design is respectively 5000mg/kgBW, 2000mg/kg BW, 500mg/kg BW, other establishes negative control and positive controls, and negative control group is given distilled water, and positive group gives cyclophosphamide 40mg/kg BW.Adopt 30 hours dose regimens, promptly twice dosing interval is 24 hours, and after the last administration 6 hours, routine was got breastbone film-making, fixing, dyeing, under oily mirror every animal is observed 1000 polychromatic erythrocytes, calculates micronuclear rates, carries out statistical analysis.
Experimental result shows: (1) negative control group micronuclear rates 1.1%
0, positive controls micronuclear rates 34.8%
0, U=17.78＞2.58, P＜0.01, negative control group and positive controls have utmost point significant difference (P＜0.01) that the animal subject sensitivity is described, and test is reliable.
(2) three dosage group micronuclear rateses all＜3%0 in normal range, are not dosage-reaction relation, and each dosage group is compared the U assay with the solvent control group, no significant difference.
Therefore can estimate this oral cavity cleaning bacteriostat in being subjected to the amount of reagent scope to PCEMNR micronucleus test feminine gender, do not have the micronucleus effect that causes.
Experimental example 8, the oral cavity cleaning bacteriostat stability test;
Experiment is undertaken by GB15979-2002 " disposable use hygienic article sanitary standard " appendix C 4.1, C6.1.The oral bacteriostasis cleaning agent is placed 14 days, 37 ℃ placements after 90 days through 54 ℃, 1.1: 3 diluent is to Candida albicans effect 1min, average bacteriostasis rate is respectively 68.10% (65.94%～70.69%), 66.43% (62.93%～69.11%), according to experimental standard, think that this product is inhibited to Candida albicans.
Experimental result shows: at room temperature this product storage life, can be decided to be 2 years.
Compared with prior art, the present invention has the dual-use function of toothpaste and collutory, and is the oral care product that adopts plant extraction liquid to make, and has natural health, and function is dual, and use aspect, safety prevent characteristics such as halitosis.Use the back people can feel that oral cavity fresh and cool is comfortable.
The specific embodiment
Embodiments of the invention.Get Oleum Blumeae Balsamiferae 10Kg, Oleum menthae 5Kg, sorbitol 56Kg, glycerol (or 1,2 propylene glycol) 144Kg, sodium carboxymethyl cellulose (or sodium hydroxyethlcellulose) 30Kg, sodium bicarbonate (or sodium carbonate) 20Kg, sodium benzoate (or mixture of methyl parahydroxybenzoate and ethylparaben) 2Kg, sodium lauryl sulphate 25Kg, tween 20 5Kg, Arlacel-80 10Kg, food coloring light blue (5% solution) 4 parts of Kg, edible ethanol 80Kg, distilled water 609Kg are raw material.Prepare oral cavity cleaning bacteriostat by following step:
A, with the mixture of sodium bicarbonate or sodium carbonate, sodium benzoate or methyl parahydroxybenzoate and ethylparaben, add in the distilled water of 1/2nd prescription total amounts, mix homogeneously, the distilled water that adds food coloring light blue or food coloring Huang or food coloring green solution and 1/3rd prescription total amounts again, after stirring, get solution A;
B, first with 1,2 propylene glycol or glycerol, sorbitol, sodium carboxymethyl cellulose or sodium hydroxyethlcellulose mix homogeneously, and, get solution B with its slow adding in the solution A under stirring;
C, the Oleum menthae and the Oleum Blumeae Balsamiferae of recipe quantity is dissolved in recipe quantity ethanol in, add in the solution B mixing behind the mix homogeneously, the distilled water that adds surplus adds sodium lauryl sulphate, tween 20, the Arlacel-80 of recipe quantity, mix homogeneously again, fill gets product.Finished product is a semi-solid, and blueness is translucent.
Claims (5)
1. oral cavity cleaning bacteriostat, it is characterized in that: this antibacterial is to make with the following weight parts proportion raw material; 5～25 parts of natural botanical extraction liquids, 1～15 part of Oleum menthae, 170～210 parts of auxiliary agent 1 components, 20～40 parts of auxiliary agent 2 components, 10～30 parts of inorganic salts, 1～5 part of antiseptic, 27～55 parts in surfactant, 1～10 part of pigment, 60～100 parts of edible ethanols, 500～800 parts of distilled water; Wherein: natural botanical extraction liquid is a Herba Blumeae Balsamiferae wet goods natural botanical extraction liquid, and auxiliary agent 1 component is 1: 2～3 by the weight ratio of sorbitol and 1,2 propylene glycol or glycerol formation, and auxiliary agent 2 components are made of carboxymethyl cellulose or sodium hydroxyethlcellulose.
2. oral cavity cleaning bacteriostat according to claim 1 is characterized in that: inorganic salt is made of sodium bicarbonate or sodium carbonate; Antiseptic is made of the mixture of sodium benzoate or methyl parahydroxybenzoate and ethylparaben; Surfactant is made of for 5～15 parts 20～30 parts of sodium lauryl sulphates, 2～10 parts of tween 20s, Arlacel-80.
3. oral cavity cleaning bacteriostat according to claim 2 is characterized in that: be to be made by the raw material of following weight parts; 7.5～12.5 parts of natural botanical extraction liquids, 2.5～6.5 parts of Oleum menthae, 53～58 parts of sorbitol, 130～148 parts of 1,2 propylene glycol or glycerol, 25～35 parts of sodium carboxymethyl cellulose or sodium hydroxyethlcelluloses, 15～25 parts of sodium bicarbonate or sodium carbonate, 1.5～3.5 parts in the mixture of sodium benzoate or methyl parahydroxybenzoate and ethylparaben, 22.5～27.5 parts of sodium lauryl sulphates, 2.5～6.5 parts of tween 20s, 7.5～12.5 parts of Arlacel-80s, green 3.5～7.5 parts of food coloring light blue or food coloring Huang or food coloring, 75～95 parts of edible ethanols, 580～750 parts of distilled water.
4. oral cavity cleaning bacteriostat according to claim 3 is characterized in that: the raw material by following weight parts is made; 10 parts of Oleum Blumeae Balsamiferaes, 5 parts of Oleum menthae, 56 parts of sorbitol, 144 parts of glycerol, 30 parts of sodium carboxymethyl cellulose, 20 parts of sodium bicarbonate, 2 parts of sodium benzoate, 25 parts of sodium lauryl sulphates, 5 parts of tween 20s, 10 parts of Arlacel-80s, 4 parts of food coloring light blues, 80 parts of edible ethanols, 609 parts of distilled water.
5. as the preparation method of the described oral cavity cleaning bacteriostat of arbitrary claim in the claim 1 to 4, it is characterized in that: prepare by following step:
A, with the mixture of sodium bicarbonate or sodium carbonate, sodium benzoate or methyl parahydroxybenzoate and ethylparaben, add in the distilled water of 1/2nd prescription total amounts, mix homogeneously, the distilled water that adds food coloring light blue or food coloring Huang or food coloring green solution and 1/3rd prescription total amounts again, after stirring, get solution A;
B, first with 1,2 propylene glycol or glycerol, sorbitol, sodium carboxymethyl cellulose or sodium hydroxyethlcellulose mix homogeneously, and, get solution B with its slow adding in the solution A under stirring;
C, the Oleum menthae and the Oleum Blumeae Balsamiferae of recipe quantity is dissolved in recipe quantity ethanol in, add in the solution B mixing behind the mix homogeneously, the distilled water that adds surplus adds sodium lauryl sulphate, tween 20, the Arlacel-80 of recipe quantity, mix homogeneously again, fill gets product.
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| CN101623248A (en) * | 2009-05-25 | 2010-01-13 | 柳州两面针股份有限公司 | Medicated toothpaste |
| CN102512344A (en) * | 2011-12-28 | 2012-06-27 | 中国热带农业科学院热带作物品种资源研究所 | Blumea balsamifera extract, preparation method and application thereof in oral care and clean product |
| CN103191032A (en) * | 2013-04-23 | 2013-07-10 | 上海医疗器械股份有限公司齿科材料厂 | Taking-off free cleaning agent of oral restoration and preparation method of cleaning agent |
| CN104887581A (en) * | 2015-06-11 | 2015-09-09 | 云南天美天康生物科技有限公司 | Oral care composition and preparation method thereof |
| CN105125447A (en) * | 2015-09-23 | 2015-12-09 | 北京水木中天植物科学研究院 | Oral sanitary collutory |
| CN105193665A (en) * | 2015-10-26 | 2015-12-30 | 中国热带农业科学院热带作物品种资源研究所 | Blumea balsamifera oral care solution, and preparation method and application thereof |
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| CN102512344A (en) * | 2011-12-28 | 2012-06-27 | 中国热带农业科学院热带作物品种资源研究所 | Blumea balsamifera extract, preparation method and application thereof in oral care and clean product |
| CN102512344B (en) * | 2011-12-28 | 2013-06-05 | 中国热带农业科学院热带作物品种资源研究所 | Blumea balsamifera extract, preparation method and application thereof in oral care and clean product |
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| CN109758392A (en) * | 2019-01-30 | 2019-05-17 | 河南中医药大学 | A kind of women oral-cavity article that cooperation toothpaste uses |
| CN109925275A (en) * | 2019-01-30 | 2019-06-25 | 河南中医药大学 | A kind of male's oral-cavity article that cooperation toothpaste uses |
| CN112870115A (en) * | 2021-02-25 | 2021-06-01 | 中国热带农业科学院热带作物品种资源研究所 | Special-effect south medicine compound toothpaste for middle-aged and elderly people and preparation method thereof |
| CN113274306A (en) * | 2021-05-28 | 2021-08-20 | 陕西省人民医院 | Preparation method of daily-use healthy and environment-friendly oral deodorant |
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| CN100408024C (en) | 2008-08-06 |
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