DE3014524A1 - Wound medication - Google Patents

Description

Annot .: Richard A. KriuLson B 25 - B

Usually bandages are used around open ounds and to cover burns. Here there is always an urgent need for a non-allergenic , antibacterial and fungicidal compound that has high quality healing properties and nevertheless the covering of the ounds or burns allowed without the growth of the tissue-healing in full · or causing similar associations.

More than two years ago, before the invention of the Substance, was only sugar, either. As single component or in conjunction with povidone-iodine (betadine solution). During this time it was the sugar (if the wound was deep) put directly into the wound. One 4-inch (10.16 centimeters) by 4-inch large sponge or other dressing material soaked in a betadine solution and used to bandage the uunde. The association was intermittent changed from 6 to B hours. Less deep ounds were made with sponges immersed in betadine solution which were then covered with about 0.25 inches (0.635 centimeters) of sugar and face down the Uunde were placed (sugar in direct contact with the Uunde).

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Bfcätadin (Betadine) is a product of Purdue Frederick Company with the following composition:

PVP-J powder 125 kg

Sodium phosphate (tribasic) 7.5 kg

Triton X-114 4 kg

Water qs 1,000 1

Triton X is octylphenoxy polyethoxyethanol. In the FRG will Betadine sold under the Betaisodona trademark. Betadine ointment is also made by Purdue Frederick Company sells and has the following composition:

PVP-J powder 45.5 g

Polyethylene glycol (PEG) 400 272.4 g

PEG 4000 113.5 g

Water qs 453.6 g

PEG 400: molecular weight between 3050 and 420 PEG 4000: "" 3,000 and 3,700

If there were difficulties in handling and there was a lack of control and uniformity of the cases, the time for wound healing was markedly shortened in this way. The use of povidone-dod solution in conjunction with sugar has been found in more than 3GO cases

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as a safe, reliable and fast method for Healing of a number of different types of wound. This includes as well pure and infected as also fresh and old dogs. Their diversity ranged from simple abrasions of the skin and flesh to severe, soft tissue injury (Tissue trauma), including burns, Bruises, shot-shot and shot-ounds; Bedsores, diabetes and circulatory ulcers, as well as open fractures.

In the case of severe, existing head injuries (head trauma, such as shotgun injuries and second or third degree burns), debridement was just as necessary as the routine care of the patient ^by system antibiotics, a rapidly forming, granulating uund, without crust formation and superficial infection, was produced.

Amazingly, a large amount of granulating tissue was formed by this treatment

sufficient to fill in large soft leg injuries, the subsequent side effects, which only appeared secondarily to the original Uunde. The newly sprawling one grew rather quickly Tissue granulation naturally covered by skin. As a result, a great shortening of the healing time was achieved and a necessary tissue transfer is restricted. In general a regeneration of the tissue was achieved sooner than a shrinkage of the uunde. In many cases it was healed uunde soft and elastic, with good sensitivity.

There is good evidence to suggest that sugar products, such as honey and molasses, have been applied in the past in ounds to be treated, including burns became. The evidence suggests that the Native American Indians all the way to the Inca Empire were in use

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Some medical compounds have had experience and show promise in the treatment of wounds and burns. These included: herbs, root extracts, leaf extracts, and various Maple molasses, millet, flelasse, and finally honey Sugar (uie sugar cane) «In ancient Egypt uurde to Preservation of food and for the treatment of '* ounds including the use of sugar products.

Povidone-Dod (PolyvinyIpyrrolidone-Dod Complex) is topically anti-infectious ("The Merck Index ¹¹ , 9th Edition, pages and 997, entry 7499, Merck & Co., Inc., 19Ve) and on the market in a variety Available in forms for sale, ZoB. Betasin antiseptic gauze pads, solution, solution swab, spray cans, surgical disinfectants for the hands, vaginal irrigation, vaginal gel, skin cleansers, SalbB} microbicidal bath, perineal bath, strudel concentrate ( Physicians Desk Reference (PDR, 31st Edition, pages 1263-1265, 1977).

The invention is based on the object of providing a wound healing agent to create, the effect of which is considerably improved compared to the known means and which is particularly easy to use. In particular, it is the aim of the invention

1. To deliver a mix that encourages the growth, the foil planting inhibits bacteria and fungi where they come into contact and kills bacteria and fungi.

2. To deliver a microbicidal, antibiotic mixture, which, as a result, when used as a wound dressing, leaves a clean, debrid wound.

3. Deliver a mix that is consistent and that Direct use allowed in open wounds and in conjunction with dressings in open wounds and burns.

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4. To provide a mixture that is stable, durable and temperature resistant with respect to separation or crystallization, or ultimately, for example only after being stirred before use, suitable for use with foreseeable effects.

5. To provide a mixture that cleans the contacted tissue so that a shaping, granulating tissue can embed.

6. To provide a mixture that will aid in the formation of overgrown granulation in a clean environment.

7. To deliver a mixture that supports epithelial formation on the edges of the wound while the granulation layer fills the damage without crusting or scabbing.

B. To deliver a mixture which completely or n .-) almost completely covers the ound with skin.

finished, usable

9. To deliver a / mix, uelche instead

as a) antibiotic.es and antifungal agent, b) as food for the granulation vessel

and c) serves as a support for the skin covering.

10. To provide a mixture that serves as a local anesthetic and thus makes the use of narcotic agents avoidable.

11. To provide a mixture, uelche the growth of the uundgeuebes in gauze vein similar associations reduced or eliminated entirely.

12. To deliver a mixture that supports regeneration.

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13. A water soluble and washable antimicrobial To deliver product that is gentle and somewhat granulating

Has texture and is applied directly to ounds and burns used; which promotes faster healing with minimal scarring, easily attached to Uer-r ties and inhibits the growth of gel granulation into the dressings.

14. To deliver an economical mix that is effective for Treatment of wounds of all types is and in humans and

Can be applied to animals.

15. Deliver a uniform mixture so that there are not separate ingredients on the wound and / or the dressing material must be applied.

16. Eii. medical mixture to deliver that directly on the wounded tissue can be used and also remains stable there.

17. Deliver a medicinal mixture, either directly on the wounded tissue or on bandages Easily applicable - without the risk of being displaced or unintentional exit from the scope.

IB. A medicinal blend of consistent quality too deliver that retains its properties and is easier to use Proper use leads to predictable results.

19. To deliver an essentially non-drying medicinal mixture that does not and therefore does not harden glued to the wounded tissue on which it is applied

20. Deliver a consistent, medicinal blend

dis can be handled easily, which does not flocculate and itself not decomposed in any other way either.

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21. To provide a substantially homogeneous mixture for the treatment of burns .and open wounds that are in is highly accepted by patients.

the

22. Deliver a medicinal mixture / remain in place when applied directly to wounded tissue and can be easily removed at a later time without damaging the tissue.

23. To deliver a mixture for the treatment of open wounds that has a long shelf life, cleansing and healing properties and therefore reduces the frequency of dressing changes to a minimum.

24. A gentle and mild medicinal blend to deliver that with minimal irritation, if any, to the wounded Tissue to be applied.

25. To deliver a medicinal mixture that completely and evenly covers the wounded Fabric allowed.

26. Deliver a blend that has a cooling pain reliever Has an effect on the wounded tissue on which it is applied.

27. To deliver a mixture that allows the even, controlled application of sugar substances and fungicides /. antibacterial Substances in direct contact with the wounded tissue allows, the contact with respect to this both components is predictable and constant.

28. To deliver a wound healing mixture that promotes the formation of healing tissue so that solid granulating Tissue is created which continues to build and become surface tissue as the wound heals.

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29. Delivering a wound treating mix that is one has improved debridement and scab formation reduced.

30. To deliver a wound treatment mixture that is easy with minimal instructions from the patient himself can be applied.

31 'A mixture to deliver, with dc-; r the wounds of the Patients can readily be properly connected.

32. To deliver a wound treatment mixture that enables that the wounds remain essentially odorless.

33. To deliver a wound treating mixture which Immediately upon application takes effect without compliance necessary "sterile" conditions and therefore a significant reduction in the costs of dressings and the associated ones Materials and the time required to apply and change dressings.

These tasks are performed by the wound healing agent according to Invention solved. The subject of the invention is a wound healing agent, which is characterized by the fact that it is essentially homogeneous and contains the following components:

a) 10 to BO parts by weight of an antibacterial tissue nutrient,

b) 1 part by weight of effective fugicidal / antibacterial Means that is physically, chemically and pharmacologically compatible with a), and

c) a sufficient amount of carrier substance that the Mixture gives a consistency in which the agent is simply applied to a sponge or gauze and in which it remains at the application site if it is applied directly to the tissue of an open wound or

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a burn wound is applied and this carrier substance is physically, chemically and pharmacologically compatible with both a) and b) and theirs Amount does not exceed one third of the weight of the wound healing agent.

Further embodiments of the wound healing agent according to the invention and its application emerge from the subclaims.

The wound healing agent from a) fungicidal / antibacterial agent such as povidone iodine, b) antibacterial tissue nutrients, e.g. Sugar (which is a strong antibacterial agent even in high concentrations and stimulates tissue granulation, and c) a suitable vehicle in the correct proportion, is a stable, effective antibiotic composition, which facilitates the healing of wounds on which it is applied directly. It prevents the growth of the granulating tissue into the associations covering them and otherwise fulfills the aforementioned tasks in every way.

The fungicidal / antibacterial agent is something that is compatible with sugar. It is preferably water-soluble, both for its handling and its removal relieved by the tissues to be treated.

It is preferably non-allergenic so its There are hardly any limits to the application. Povidone iodine fulfills all of them these criteria. It is a particularly good fungicide / antibacterial agent and has been used in the following Application examples used throughout. However, you can also

fungicidal / antibacterial agents compatible with sugar and are therapeutically suitable for use in open wounds, with sugar, e.g. cane sugar, dextrose, maltose, Fructose, honey and / or molasses can be combined.

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Povidon-3od is preferably used in the form of Betadine ointment (10% povidone iodine) and Betadine solution (10 % povidone iodine). These substances are defined in more detail on page 5. Since these substances already contain suitable carrier substances, a Separate addition of carrier substances is not necessary. On the other hand, the fungicidal / antibacterial agent can be mixed with sugar and any (preferably) water-soluble, neutral, physiologically acceptable ointment base, e.g. Unibase and possibly water (to reduce the viscosity) or e.g. carboxymethylcellulose (to increase the Viscosity) can be combined in order to obtain a suitable consistency and stability. Of course, other ointment bases, such as Vaseline, can be used if water solubility is not required.

"Unibase" is a fil-water emulsion of the Parke Davis company with the following composition:

Methyl Paraben 25D mp:

Propy 1 paraben. 150 _fn g

Sodium Lauryl Sulphate 10 g

Propylene Glyco1 120 g

Stearyl alcohol 250 g

white vaseline or paraffin oil 250 g

purified water 370 _cc

The sugar that is suitable in every grocery store is suitable as a sugar can be purchased and there is no need to specially clean, sterilize or otherwise treat it. Although sucrose is preferred for its lower cost and ready availability, it may or may not be dare can be completely replaced by dextrose, maltose, fructose, honey, molasses or similar substances with a high sugar content.

All of the sugar mentions mentioned herein include, optionally (individually or in any combination) each of the aforementioned substances} All exemplary embodiments are based on general common granulated sugar.

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/ The ratio of sugar to, e.g., povidone-iodine, is important from a cost standpoint, ease of use and effectiveness. When the povidone iodine in the form of Betadine ointment and If Betadine solution is present, the weight ratio of sugar to Betadine ointment appropriately varies from 1: 1 to 8: 1, whereby the amount of Betadine solution increases gradually, from 0 for the 1: 1 ratio, to 0.5 ounces per pound (O, G3123 grams per gram) for the ratio 2.5: 1, to 1 ounce per pound, for the ratio 4: 1, to 2 ounces per pound for the ratio 8: 1, (based on the total weight of sugar and Betadine ointment)

For a longer shelf life, it is advantageous to limit the ratio to 2.5: 1 to 5: 1. In this range (from 1: 1 to 2.5: 1) the constituents tend to separate, but are readily mixed again by briefly stirring before use; above this ratio (from 5: 1 to 8: 1) the Components to separate and crystallization takes place.

The preferred recipe is based on 20 parts by weight of sugar (sucrose), 5 parts by weight of Betadine ointment and 2 parts by weight of Betadine solution. This corresponds to 100 parts by weight of sugar, 3.5 parts by weight of povidone-iodine and 31.5 parts by weight of carrier substance. If the components are mixed in this ratio, there is no separation of the constituents and the agent maintains its consistency, both in heat and in cold, thus ensuring durability over a long period of time.It is also easy to apply and is particularly popular with patients. In addition, these proportions were determined through tests with a large number of proportions of the components mentioned and the given proportion was found to be the best, not only for the preparation of the mixture, but also for the effectiveness of the product with regard to the various wounds and for the treatment for which it was used. That means that a sugar content of about

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70 to BD weight percent (based on total weight the mixture], which seems to be the optimum for wound healing. This is almost the same as the concentration of sugar and honey.

Although sugar or sucrose, povidone-3od and carrier substances, which are used in Betadine ointment and Betadine solution, Often mentioned, these are just a few illustrative examples of the preferred embodiment. The composition of matter is not limited to that.

Instead of sucrose, any high concentration antibacterial agent can be used which can Promotes granulation of the tissue, like other sugars and sugary components, such as fructose, glucose, dextrose, maltose, Honey, molasses, or any combination of these.

Usually table sugar is used because of its availability and affordability preferred. If honey, molasses or a similar liquid substance is used instead of sugar, so the proportion of the separate carrier substances is either reduced or the carrier substance is omitted. Also this one In this text, constituent is usually only referred to as "sugar". In addition, the composition of the remedy is not up limited to those in which povidone-3od is the fungicidal / antibacterial component. This can be in whole or in part be replaced by one or more components with similar and / or related properties. The ingredients are either insoluble or only dispersible in water. Water solubility however, it is preferable. The ingredient could be an antibiotic, but better not. It would be ideal if it weren't for allergies. As examples of substances that contain these components in whole or in part, the following are named:

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Acrisorcinol = 9-aminoacridine 4-hexyl resorcinolate Amphotericin B Anthralin = 1,8,9-Anthracenetriol Candicidin dibromopropamidine isothionate = 1, 3-di (4-Amidi ηα-2-BronriQ phenoxy)

Propane di-2-hydroxyethanesulfonate

Domiphene bromide fluorouracil gentian violet griseofulvin Haloprogin = 3-iodo-2-propynyl 2,4,5-trichlorophenyl Hexachlorophene ichthammol C shale oil sulfonate) Jodochlorhydroxyquin = S-chloro-Z-iodo-B-quinolinol Iodoform (triiodomethane) nitrofurazone Nystatin povidone-iodine resorcinol sulfabromomethazine = 5-bromo-4,6-dimethyl-2-sulfanilamidopyrimidine 1O-undecenoic acid and / or its zinc salt

So that the mixture of sugar and fungicidal / antibacterial To obtain the desired consistency of ingredients, one or more carrier substances are usually required. In The following list shows substances that are Suitable carrier substance or from which the carrier substance is put together can be.

Cold-cream corn oil cottonseed oil Gelatin glycerin

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hydrophilic ointment hydrophilic petrolatum lanolin

Methyl cellulose olive oil

Peanut oil

pectin

Polyethylene glycol 400 polyethylene glycol 600 Polyethylene Glycol 1,500 Polyethylene Glycol 4,000 Polyethylene Glycol 6,000 Povidone

Propylene glycol colloidal silica sodium alginate Sodium carboxymethyl cellulose D-Sorbi L solution whale seeds

strength

Stearic acid steary alcohol white ointment white petrolatum yellow acid

These are common and generally recognized substances that are regularly used in the formulation of topical ointments and pastes be used. They are used in the usual way and mixed with the sugar so that a product is obtained that does not flow but has such a consistency that it can be applied while maintaining its cohesion. The mixture expediently does not contain any volatile constituents, the volatilization of which would change the consistency of the Mixing could result if, for example, a vessel in which the mixture is located remains unlocked.

The fungicidal / antibacterial component must be physically, chemically and pharmacologically with sugar or sugar containing component be compatible. Even if a separate carrier substance is used, this must also be used be physically, chemically and pharmacologically compatible with the first two necessary components.

The wound healing agent according to the invention results in a considerable advance over the known use of sugar and Betadine solution, and not just in terms of patient acceptance and ease of use in a wide variety of applications Wounds, but also in relation to the

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Mode of action of the agent. Before the introduction of the wound healing agent according to the invention it was found time and again that the tissue in the wounds grew so quickly that it tended to adhere to the dressing so that the healing process was disturbed when the dressing was applied was changed. By using the wound healing agent according to the invention, this disadvantage has been completely eliminated.

The careful mixing of the different Components has been worked out over a period of time to match the current formulation to obtain. After repeated attempts it was found that this was particularly ineffective and for sure is. It has been used in a variety of health promoting, both surgical and non-surgical treatments and in many uundsituationen in the Practice in physical therapies and in hospitals, successful applied. In many cases it has been shown to be diverse in the healing of And without the use of other surgical procedures, skin grafts, or additional antibiotics, is completely effective.

Special problems were encountered in · earlier in .Treatment ·; with sugar in connection with Betadins-Lösunj? . more often in the treatment of amputated fingertips than in the treatment of deep circles, since the healing of the fingertips took place so quickly that the granulating tissue tended to grow together with the bandage material. This created considerable difficulty in removing the dressing and was often associated with considerable pain for the patient. Although tightly attached silk or nylon bandages limited this problem, they tended to inhibit the spread of tissue granulation and thereby prevent the healing wound from being completely restored to its previous state.

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The wound healing agent according to the invention is not only an improvement, it also reduces the adhesion of the tissue with the dressing material, while the positive properties of Sugar and Betadine solution are retained, but is also easier to apply and even in consistency. In the past, the individual components were applied in different ways. Betadine Solution and Spills Sugar was found during use and caused pollution. After application, the individual components tended to dry out, the sugar crystallized and tended to disappear from or through the bandage.

Countless attempts have been made to create a mixture of sugar and povidnn iodine, which stick to the bandage and should not flow away from the tissue or bandage, the handling of which does not cause contamination led and not to sticky dressings filled with a sticky mass.

Each admixture had the result that the amount of sugar that came into direct contact with the wound was reduced. Premixed Separate preparations of sugar with povidone-3od solutions after a very short standing time, the sugar settling on the bottom and a povidone-iodine solution over it and sugar existing syrup was located. Also povidone-iodine ointments with at least 5D wt .-% ointment base separated and were sticky, sticky and greasy, while formulations with more than 80% by weight sugar tended to granulate and lost context so that it was difficult to apply and they did not adhere to the dressing. With the wound healing agent According to the invention, a sugar / povidone-iodine ratio was found from 3.5: 0.1 to 4: 0.1, the povidone iodine being 10% by weight Ointment was available as particularly cheap. This ratio range results in an optimum of wound healing properties, safety and economy.

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The above ranges and ratios relate to the mixture of sugar with different combinations of Betadine ointment and Betadine Solution because these povidone iodine products are easy to use are made. When the wound healing agent from 20 parts by weight Sugar, 5 parts by weight of Betadine ointment and 2 parts by weight Betadine solution is made so that it is essentially homogeneous, it is particularly effective, very economical, temperature resistant and durable. The resulting ratio (20: 0.7) of sugar to povidone iodine is only due to nature Limited (consistency) of the carrier substances used for Betadine ointment and Betadine solution can be used.

Other carriers (used alone or in the right combination) produce comparably stable mixtures with sugar / povidone-iodine weight ranges from 10: 1 to 80: 1, preferably from 25: 1 to 55: 1. Since povidone iodine is water soluble, water soluble carriers are preferred, but are not necessarily required. The important thing is consistency the sugar / carrier mixture. If the consistency is similar to that of the mixture mentioned above, then one is suitable Contain amount of povidone iodine to produce a homogeneous product, that has the desired weight ratio of sugar to povidone iodine. A vehicle is selected so that the Sugar 2/3 or more of the end product (including the carrier substances) made to deliver the desired sugar concentration, which is in direct contact with the treated Tissue is brought. By selecting water-soluble carriers of different consistencies and different sugar concentrations stable mixtures are obtained. The addition of the suggested amounts of povidone iodine to a stable one Mixture of sugar / carrier substance has no significant influence on the consistency or the stability of the mixture.

Suitable pharmacologically recognized water-soluble carrier substances are known and their particular selection or

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Combination is not the subject of the invention. The carrier substances, the same for Betadine ointment and Betadine solution can also be used with a higher or lower concentration of povidone-3od.

If the povidone-iodine concentration is 20% by weight in both is increased, the wound healing agent has [according to the specified Composition) a sugar / povidone weight ratio of 20: 1.4 when reduced to 5% by weight in both the wound healing agent has a sugar / povidone weight ratio of 20: 0.35.

If the viscosity of the mixture of sugar and carrier substance is too low, a small amount of a viscosity-increasing agent can be used Means such as carboxymethyl cellulose added will. Agents like this also add to the stability of the mixture.

Although a stable homogeneous mixture is preferred and stated here less stable blends offer many of the benefits mentioned, and most of the therapeutic properties, as long as a high concentration of sugar is in contact with the surface of the wound. When the wound healing agent before is brought to a substantially homogeneous consistency after use by mixing, when attached to gauze or the like Material adheres and if it remains in the area of the wound to which it was applied, then it is clearly in question to a wound healing agent according to the invention, even if it has the tendency after a standing time of a few Hours to separate in a vessel.

Care must be taken to ensure that the wound healing agent is manufactured in a clean environment and in clean equipment. The use of mixers and spatulas stainless steel is recommended. The wound healing agent is packaged in opaque plastic containers that have previously been placed in the The dishwasher can be cleaned and sealed airtight after filling.

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For the production of the wound healing agent, for example 453 g PovidorrJ ad solution (10% by weight), like Betadine solution and 2,268 g of povidone iodine ointment C10% by weight) such as Betadine ointment placed in a stainless steel container with a capacity of 18.927 liters. Mixing is done with a Stainless steel blade, driven by a 1/2 HP motor and using a reduction gear, which is intended for the production of pizza dough. When the mixture has a uniform consistency has reached, 9.o72 g of sugar are slowly added until the batch has a uniform consistency.

The equipment and mixing devices are made of stainless steel to avoid the possibility of contamination of the wound healing agent with softer metals, such as aluminum, to exclude or reduce. All utensils including The mixing vessel and stirrer, the stainless steel spoon and the filling container are in front Washed with soap and water after use.

When the mixture is uniformly consistent (usually after 10 minutes), the batch is weighed out in clean, 0.5683 l plastic containers. These are just difficult translucent. After they have been weighed, the containers are tightly closed and labeled, which indicates the date when the batch was manufactured. The product retains its consistency over a period of time during storage Period of more than 6 months.

There are two basic techniques for applying the wound healing agent to the wound. If the wound is deep, the medicine becomes direct spread on the wound and then with a 1o, 16 χ 1α, 16 cm Gauze pads or other suitable dressing material covered. The wound healing agent stays on the wound and is simplified it to apply the bandages. The more general

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Technique is to apply the wound healing agent directly to a 1o, 16 χ 1o, 16 cm Putting on gauze pads like spreading peanut butter on a slice of bread. The gauze pad will then be with the medicament side laid down on the wound. This method is more effective when dressing on burns and others flat wounds are applied.

That is, the medicine is applied to the wound so that it completely covers the injured surfaces. Usually is the layer of wound healing agent 0.635 cm thick. How often a dressing change should be done is determined by the condition of the wound. With highly contaminated (purulent) or weeping For wounds, a dressing should be changed every 4 to 6 hours - while for other wounds a dressing should be changed less often, sometimes just once or twice a day.

It is beneficial if the bandages are changed three to four times a day will. Because the tissue develops faster in fingertip amputations, these dressings should be changed a little more often. Each time the bandage is removed, the residues can easily be removed with tap water or if desired, can be washed off in a whirlpool. In approx. 50% of all cases it is helpful to remove the wound before the To clean wound toilet with hydrogen peroxide, and that may be required up to once a day for some wounds.

The wound healing agent tends to increase the bleeding of the wound, if applied to bleeding wounds within 24 hours of the injury. For this reason, after cleaning or the wound toilet in general, iodoform is first used to stop bleeding and the wound healing agent is used not applied before the following day or before the bleeding has stopped.

When the wound stops bleeding, the wound healing agent will like applied above and the bandage applied several times a day

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changes.

When epithelial tissue forms, a ring sometimes appears of white tissue between the growing tissue and the granulating tissue. Then mostly at this point Debridement once or twice a day to achieve full skin coverage without indentations or other defects occur in the wound area.

Repeated, daily dressing changes are continued until the wound has healed. The healing time is different. It depends on the type and depth of the wound. But all wounds treated in this way are good and relatively quick healed.

The wound healing agent according to the invention in a composition of 20 parts by weight of caster sugar, 5 parts by weight of Betadine ointment and 2 parts by weight of Betadine solution (US-TM "Sugardyne") was included useful on a wide variety of walls, both infected and non-infected. Infected wounds were with Staphylococcus aureus, E. coli and Pseudomonas aeruginosa, likewise both combined, and many other bacterial species, contaminated. Successfully treated wounds closed abrasions, older lacerations and gunshot wounds and shotgun-bullet wounds one that resulted in both minor and major soft tissue injuries and injuries due to open fractures. Other injuries treated were spider bites with subsequent necrosis and burns first, second and third degree, chilblains, open fractures on the bone, pressure ulcers, pressure ulcers, diabetic and stasis ulcers. However, the wound healing agent showed no success in the treatment of poison ivy and poison oak poisoning unless the patient has abraded the surrounding skin and she was infected.

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Some success has been achieved with psoriasis; there is a tendency for psoriatic wounds to heal. A heavy, protruding one Carcinoma on the skin of a 98-year-old patient rapidly decreased in size.

The wound healing agent has shown exceptional effectiveness in the treatment of a wide variety of common and more unusual human wounds in which bacterial and fungal contamination commonly occurred. There is an extremely high success rate with fast healing, Reduce hospital time for patients and reduce the time patients spend in the burn department spend and discharge patients faster. There's a big improvement in the bottom line, through the faster healing and the elimination of further surgical procedures, including skin grafts.

In those cases where skin transfers were required, the injuries inflicted on the donor were with the wound healing agent treated. These areas are without scarring healed and it was difficult, if not impossible, to determine that they had served as a donor agency.

The wound healing agent has not only been shown to be an effective remedy, but has also been anesthetizing due to its anesthetic nature Effect makes the need for administration more addictive Drugs decreased. In the past, many patients would normally have had anesthetic drug before or after the dressing change demands. This has been kept to a minimum by the wound healing agent. This is especially the case when patients have large open wounds, including painful burns, for which the application is anyone local application of medication is uncomfortable.

Therefore, the wound healing agent has, besides wound healing properties helped reduce potential addiction to narcotics

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that, which can occur especially in patients who are treated with it over a long period of time.

For the most part, wounds treated in this way healed without scars or with only minimal scarring. The wounded area remained with a normal colored skin back and soulful and there was no recurrence of infections or productions of Inflammation of the bone marrow in any patient to date. In many cases, the wound healing agent has been used Antibiotics not used or only used in small doses. In many cases the wounds treated were the worst, that the inventor has ever seen and they have healed well. More than that, even deep wounds grew on the healed Tissue surface again hair. Notwithstanding baktea ieller or fungal contaminants successfully healed the wounds. This was true where all other products used failed and where all antibiotics used were ineffective. This was true when the admixture was in a "non-sterile" form and was applied without observing "sterile" procedures.

The wound healing agent is an effective medicine that has been used and is helpful in the treatment of:

1. Abrasions (infected and non-infected)

2. Abscesses (udder lumps / boils)

3. Acne (infected and non-infected)

4.Burns (infected and non-infected)

a) general burns

1. First degree

2. Second degree

3. Third degree

b) other burns

1. by electricity damage

2. by chemicals (acids, alkalis and

other)

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3. Frictional injuries (ropes, plasters)

4. Sunburn

5. Carbuncle (oozing and festering)

6. Skin cancer (infected and non-infected)

7. Bruises as a result of accidents - reduction of Tissue, edema

8. Means for debriding necrotic tissue (Brown Recluse Spider Bite) infected and uninfected)

9. Deep wounds (infected and non-infected) 1 ο. Sore rose

11.Exposed bones (infected or non-infected)

12. Panaritium (only after incision and discharge) 13 Fingertip amputation (large and small) (infected and non-infected)

14. Fracture Blisters (Infected and Uninfected)

15. Frost damage (infected or not infected)

16. Tissue necrosis (infected or non-infected)

17. Gunshot wounds (infected or non-infected) 1B. Lacerated wounds (infected or non-infected)

19. Wounds open to the bone (infected and non-

infected)

20. Inflammation of the bone marrow

21. Nail fold panaritium

22. Perinal abscesses

23.Cysts in the hair area (infected or non-infected)

24. Post-operation groups (infected or not

infected)

25. Psoriatic wounds

26. Shotgun gunshot wounds (infected or non-infected) 27 Ν.ίΜ t abscesses

28. Amputation stump and guillotine amputations (infected or non-infected)

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030 0 44/0735

29. Ulcers (infected or non-infected)

a) Decubitus ulcer

b) diabetic ulcer

c) pressure ulcer

d) congestion Ctroρhisch)

To date, no attempts have been made to treat injuries to the eyes, ears, nose, throat or genitals and the wound healing agent has no particular effectiveness in the treatment of viral diseases, with poisoning Poison ivy or poison oak shown. But it was effective in the treatment of all wounds, even if they were caused by bacteria, Fungi or both were contaminated. It was effective against both gram positive and gram negative bacteria .

The wound healing agent in the form of a substantially homogeneous mixture of 10 to 8o parts by weight of a suitable one Containing sugar (antibacterial tissue nutrient) or sugar Constituent t2 in part by weight of a physical, pharmacological and chemically compatible fungicidal / antibacterial active * substance that is pharmaceutically suitable for direct application on the tissue of open and deep wounds, and at most 33 1/3% by weight, based on the total weight of the wound healing agent, of pharmacologically suitable, physically, chemically and physiologically compatible carrier substance, which in quantity and physical properties are sufficient to give the wound healing agent a consistency that allows the wound healing agent to be easily applied Spread on a gauze pad or gauze bandage so that it adheres and stays in place, when applied directly to the tissue of an open wound or burn, it is easy to apply. After this the wound is cleaned with water or with hydrogen peroxide the medicine is usually applied to a 1o, 16 χ 1o, 16 cm gauze pad with a spatula or knife and the gauze pad is then placed on the wound with the

U30044 / 0785 - ₂ g -

dizine side down (directly on the tissue). Alternatively the medicine is applied directly to the wound and then covered with a gauze pad.

The wound healing agent in the composition of 2o parts by weight of caster sugar, 5 parts by weight of Betadine ointment and 2 parts by weight Betadine solution (US-WZ Sugardyne) can easily stored. Even after a long period of storage does not separate it, regardless of whether it is stored at normal room temperature, in a warm room or in a refrigerator. Samples have been stored under these conditions for more than six months without su | ..jration or contamination. It has there was neither a failure nor a reduction in effectiveness, despite manufacture and storage under non-sterile conditions Conditions. Cultures were always negative.

The wound healing agent has been applied to most wounds in a non-sterile manner without causing any harm Results would have come. Oedes of its constituents and the wound healing agent itself are water-soluble and stain neither the skin nor the clothing permanently. If discoloration occurs, it can be easily cleaned with water and a mild detergents are removed.

The wound healing agent does not cause pain when used. Most patients experienced rapid pain relief after application. If it's on a burn When applied, it creates a fasu anesthetic giant Feeling immediately after application. A few patients feel mildly hot after application of the Wound healing agent) rarely becomes a feeling of pain communicated. The feeling of heat described is short-lived and no patient has previously reported such discomfort, that the use of the wound healing agent had to be discontinued.

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The wound healing agent prevents new tissue from growing in the dressing material while it prevents the granulation tissue from growing promotes. This makes it easier to change the dressing without disrupting the healing of the wound and without the patient Inflicting pain. When it is absorbed, it is converted and not excreted. There is no evidence that this absorption is damaging. When sucrose from the tissues fluid and bacterial enzymes to the If the wound surface is hydrolyzed, the absorbed substances would be glucose, fructose and / or their conversion products be.

In contrast to sodium chloride, these substances are used in the Metabolism implemented and not excreted from the human body as such. That is why we educate older people Heart or kidney disease the absorbed products do not pose any potential cardio-vascular-renal problems. Still there there is no evidence that the product causes diabetes, neither in diabetics nor in non-diabetics. It No harmful effects could be found after the application of the wound healing agent except for the above Bleeding stimulation when applied to -fresh bleeding wound bin that can be prevented by taking the precaution described above.

Where a comparison was possible in one and the same patient, the wound healing agent has outperformed all other drugs, commonly used for treating similar wounds will. These drugs include Silvadene, iodoform gauze, xeroform gauze and also if applied alone to Povidon-3od ointment and Povidon-3od Solution.

Silvaden Cream is an ointment from Marion Lab. Inc., Kansas City Missouri, USA, with the following composition:

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030044/0785

Silver sulfazidine (1%) finely divided in a hydrophilic base white petrolatum, steary alcohol, isopiopy 1-myristate, Sorbitan monooleate, polyoxyl-4o-stearate, propylene glycol, Water and 0.3% methyl-paraben as a preservative]. Xeroform is a powder with tribromophenol bismuth.

Comparisons showed that most burns and wounds that normally form scabs (scabs) out of most other products have been trained while the wound healing agent stops them. The result will be a very pure, fast-granulating wound, reached in a short time, generally in 1 to 3 days. Though the use of the wound healing agent generally reduces the need for skin grafts, so can wounds that have such require treatment at an earlier date. Furthermore, most other products require the accompanying one Use of antibiotics. This has usually not been necessary when using the wound healing agent.

The hospital time in the burn ward is reduced with the use of the wound healing agent because the burns wounds quickly convert to clean, healing, uncontaminated wounds.

Since there are no contamination problems, the burn patient can be treated with whirlpools and multiple dressing changes outside of the incineration station. Patients are not only discharged from the burn unit earlier, but also not from burns suffering patients, they are largely more likely to be discharged from the hospital.

The wound healing agent was particularly helpful in treatment by diabetics who would normally have to undergo an amputation after developing a diabetic ulcer at the foot. The medicine achieved a quick cure

0 30044/0785

32

30U524

diabetic ulcer, good results even in the face of fairly large contaminated ulcerative areas, including Osteomyelitis below the ulcer. It also had fairly quick healing results for underlying osteomylitis, though in many cases no antibiotic was used or was less effective, according to laboratory tests.

To date there has been a reduction in the number of amputations given to diabetics because the early diabetic ulcer, even with underlying osteomyelitis, usually pops up quickly treatment with the wound healing agent reacts. Wounds Extremities (especially: fingers and toes) of non-diabetics who are known to undergo an amputation had a better chance of life and could be treated successfully. Skin transfers were in their number decreased as the wound healing agent tends to quickly fill the defects created by the wound. It leaves one behind clean granulation tissue, which subsequently reaches the level of the surrounding normal, soft tissue. It epithelializes with normal sensitive skin and skin color.

Scars are barely visible, defects are minimal, and patients are very happy with the results. Most of the patients are able to use the wound healing agent at home without any particular difficulty and the number of visits to the Hospital, hospital visits for physical therapy or in the doctor's office are reduced.

Most of the wounds that have been treated with the wound healing agent are wounds that would normally be expected they heal more slowly as it is a healing with suppuration. Actual results show that these wounds heal much faster than those wounds that are not

- 33

030044/0785

30U524

treated the same way; it is significant that many as fast as pusless wounds healed.

The wounds heal in a short time with minimal scarring; the healed tissue is free of hypertrophic Scar. Until today there has been no KüloiiYes. As well as Laypeople and doctors alike agree that wounds heal "without scars".

The color and feel develop to normal. The damaged neutral item will be damaged in such a way promoted in growth that the injured area is innervated and returns to normal feeling.

Wounds in which bones were exposed and infected responded on treatment in a dramatic way. Exposed, infected, uncovered and unprotected bone will usually die off. Most doctors agree that every possible attempt should be made to cover these exposed bones, also at the risk of infection. Countless surgeries have been devised to to achieve this goal. These operations include skin transfers, wound flap closures, relaxation incisions with displacement of tissue over exposed areas, muscle restraint and muscle transfers, win also abdominal, Cross-arm and cross-leg lobes. Neither of these techniques had to be can still be used when in a wound in which the wound healing agent was applied, was an open bone. The wound healing agent has the structure of granular tissue to fill in the wound and to cover the bone, even up to the complete filling of the defect and the

34

030044/0785

30U52A

full skin coverage. No patient who was treated with this Wundheilrnittel, with or without the use of antibiotics, osteomyelitis has developed. These data should be compared with the incidence of osteomyelitis after treatment of open fractures in the usual manner and with the use of antibiotics, where osteomyelitis occurs in three to six percent of cases.

Limited experience has shown that the wound healing agent, Applied to fresh first and second degree burns, provided instant pain relief and quick healing of the injured areas. If there were bubbles, they either dissolved completely or were protected so that the Healing process progressed faster than usual among them. Therefore, the wound healing agent has been used successfully to treat a bring about quick healing that is related through Blisters and the risk of infection are usually a problem C such as fracture blisters or crushing). Treatment occurred in patients with third degree burns, including deep ones With the wound healing agent, a rapid transformation of the damaged tissue into clean granulation tissue suitable for skin transfer, usually in a period of 3 to 4 days.

One patient (not an adolescent) had acne on his back and this condition healed quickly after treatment with the wound healing agent. The product has had tremendous results in patients who have had suture abscesses (very similar to acne) and have been treated with it after surgery. They are usually completely healed within a day or two and there is good reason to believe that the similar effect will be achieved in adolescents with acne.

As the cost of medical treatment and hospitalization constantly increasing, is the wound healing agent that not only has healing results that have never been shown before, but that in a large number of wounds even from the patient

030044/0785

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3QU524

can be used at home with a minimum of doctor's supervision, of particular cost-reducing importance, Its components are readily available and inexpensive. The restrictions on its use are minimal and the advantages of its use far outweigh the few disadvantages.

Ü 3 G 0 U / 0 7 8 5

^ 36 -

30U524

In the following application examples, the wound healing agent is in the on page 29, in which it is combined with the US trademark "Sugardyne" has been used unless expressly stated otherwise.

With typical bandage technique with this drug, every previously used dressing material removed, the wound with soap and water and then cleaned with hydrogen peroxide, Sugardyne applied directly to the wound to make it complete the wound covers or fills. Alternatively, Sugardyne is applied to a 10.16 χ 10.16 cm Mullkussen and the resulting one Bandage is placed face down on the wound. The bandages are changed two or three times a day, the number of dressing changes and Sueardyne application depends on the type and severity of the wound. If the wounds are severe, they should be changed more often. The frequency arises from clinical Assessments and experiences. These techniques have been used in the following medical histories, unless otherwise specified is said.

I. AU is a 22 year old black male who was treated for a neuroma affecting the left big toe from which the toenail was later removed to remove the neuroma. The nail bed was first removed treated with iodoform. Thereafter, the treatment followed

τ μ
the medicine (Sugardyne) without the use of antibiotics to get a clean-healing nail bed. The Sugardyne dressings were then applied twice a day for three days.

by/
changes. AU was able to return to work without pain three days after surgery.

BAD NAL

044/0785

Comment: This case showed the ease of use of medicine and the absence of loaches outpatient treatment. It also showed the ability of Patient to return to work during the healing process.

II. A 70 year old white woman (f {A) was born on a Follow-up infection treated after a foot bone fracture. The patient had an oozing wound in the partial view her leg in the area where the operation took place. In the face of an open fracture, it would last for a long time has also been treated with antibiotics. You uurde on

TPl
daily Sugardyne dressings, with dressing changes once a day and reflex (500 mg) every six hours, (after cleaning with hydrogen peroxygen). The uund was almost completely healed after 7 days (with no signs of infection). Her treatment was painless.

J (V)

Comment: With the use of wqii Suyardyne was the treatment painless. The healing outcome was quick and treatment was easy.

III. A 12 year old outside girl (üü) became with Sugardyne

treated against Qand burns after an airing operation. Pain-free dressings were applied twice a day for three days used, after the time of which the injured skin was healed without using antibiotics and without leaving any Scar.

+) "Keflex is Cephalexin-Monohydrnt, uiπ hnltisynthet inches oral antibiotic de ?; Typns cephalosporin and is made by sold by Ely Lilly.

030044/0785

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IU. A 90-year-old white man (3D) was treated for multiple fractures on the left foot. Fr was treated for a bloodless reduction and three weeks later he was healthy again. After his cast was removed, he had a weak leg and a FuG edema. After that, terrible edema (secondary) developed immobile and added to his age. And three days after the ligament removal, he had erythema and a watery, infected area that had affected a large part of his foot, ankle, and the secondary leg that was self-induced itching. The tissue was cleaned with Betadine solution and

TM was afterwards with Sugardyne over the Uunden

TM treated. Before Sugardyne V ^e rbände were used the affected tissue was washed with hydrogen peroxide (twice a day). Although he was told to take Keflex (500 mg) every 6 hours, he later admitted that he had not taken the antibiotic. A day after his initial treatment with the drug, much of the erythema and superficial infection was cleared. Three days later the substance of the infection was healed and six days later it was almost completely healed. The healing progressed without leaving any scars.

Comment: The case shows the effectiveness of the Drug on the elderly patient with edema and erysipelas without the support of Antibiotics.

U. A 23-year-old white man (NE) received a severe gunshot wound (0.357 caliber Magnum) in the left hand on September 26, 1978, with loss of bone and soft tissue and of distal to the distal half of the 3rd metacarpal and and proximal to the proximal half, phalanx of the

030 044/0 7 8 5 ^{BATHROOM 0RIGINA} i-

- 3 ^f i -

long fingers, including the ''<V LulutJ.

He was first treated with iodoform packs at the "UI H 0 Δ open Uunüe and later he was nimble with 1L whirlpool baths 1L, Ua lu, lu: i to ff: ^Γ υρε roxi d and bandages changed mil. 5 uyardy 11 π Then underwent the uunde eini nochnin 1 i ι_, υη reuisinn, so d. his long finger was amputated.

He was diagnosed 8 days after the original injury discharged from the hospital. The Uundnn to rici. palmar and dorsal surfaces of the hand were nearly uol] -k ο mm en closed and a half un du »after the l / injury with no evidence of infection.

4 1/2 hours after the injury, ντ had the perfect Γu ηk ti ο η ability to restrain the remaining fingers and was able to form a good fist.

Comment:

This case shows the effective use of the drug Extensive in a severe gunshot wound do hand with minimal remaining scars later and faster Healing, with a quick return to work and k tior's capable hand.

VI. A 6 year old, colored dungeon (ilf) uar affnr.tmr Fallen from his bike and injured three on his left knee Days before he core to an emergency operation room, Er had a temperature of more than 39 ° C and had Get PeniciLlin. But after the first examination became an infected abrasion in and urr the Surface of the left knee noticed. The patient became

X (Vl

treated in the hot operation room with Su ^ gardync and

continue with penicillin. Had spatula a day

he pure and healing Uu η with a clear reduction

in the size of the uunde. The Uur.de var almost completely

03 0 0 44/0785 BAD ORIGINAL

3QU524

healed (π hue; signs of I nfek Li ο now ui.d mi η im al _: _ π
Scars) within G Tn ^ s thereafter.

Comment: Diaper patient overubis I die; .l, .hü11ü M ^ ilur.c,
won over people with the change of antibiotics,
the varied ineffective geuesen uar. £ ■ r uurdu ohriü treated cords; he could be treated without staying in the hospital Ui erde π.

Uli. A 20-year-old woman of color (üTG) uurda against one

T f'l infected burn on the back of her hand with Sugardyne

Acts. The bandage was changed twice a day.
The healing was in less than a week without scars
achieved.

VIII. A 36 year old, colored man (you) suffered from one
deep ridge of his right finger since a machine block fell on his hand. The sewn uuride was treated immediately. This was done by changing the association on a daily basis

TM
with Sugardyne. In terms of substance, the healing effect was completed after 9 days. Full flexion was obtained in 16 days without scarring.

IX. A 49 year old white woman (IU) in a car accident in which she has a large hematoma (accumulation of blood) on her left LJade received. This was done in the Wotoperatiuns room watered and treated with iodoform. After that, daily

TM

Changing the bandage with Sugardyne caused a wound that had not healed and healed within two weeks.

X. A 34-year-old outer man (LP) was treated for an ulcer and had many small abscesses below the
Knee amputation stump. With a variety of

030044/0785 BAD OftlGINAL

30U524

medical, local crenis, ointments, poultices, Antibiotics and steroids for about din year all unsuccessful. Upon examination, the patient showed a very large ulcer with small abscesses that is 3-inch χ 3-inch below the knee-truncated amputation on the surface uar. The patient appeared to have oath, fungal and bacterial contaminants.

T (vl

He was first with Sugardyne without the simultaneous. Application of antibiotics, treated on October 31, 1978, and two hours later the distal stump was 3/4 closed and afflicted with minimal amounts of sewing.

T | V |

The Sugardyne dressings were applied three times a day after cleaning the Uunde (each time) with water, soap and hydrogen peroxide. The Uunde was completely healed after a flonat, although the patient during treatment continued his _r A beit.

Comment: This severe ulcer-like uund reacted not responding to a variety of acceptable treatments, but immediately and without hospitalization

ΤΓΊ
Sugardyne without interrupting the work program.

The patient had no complaints during the treatment with the drug; he found it easy to use and apply.

XI. A 5-year-old white dunge was injured on his right foot, which was caught in a sawing machine He developed necrosis on the side of his foot and severe crush injuries that too resulted in tremendous swelling and blood loss.

^030044/0785

3QU524

- n 2 -

He later suffered a Faszienschnitt? N ^r ow Lnd uurde treated with whirlpool baths and Sugardyne after his Uunde treated zuei days with iodoform fluoro ^ the uar. After the iodoform was removed, the area was free of blood. The patient made great strides and the wound healed in almost three weeks. After 27 days the patient was completely healthy and had only minimal scarring, medially and laterally. He had completely filled the medial deficiency and achieved a restoration of the lateral blood that was previously necrotic. The feeling was below normal, the color, minimal scarring, and the full amount of look and function.

Comment:

The expected healing time is significantly reduced and did not require any skin grafts. The patient had

no damage during treatment with Sugardyne

XII. A 16-year-old, ueifler, man received a fingertip amputation in December 197B. First he was treated with iodoform dressings. On the next day it took place the amputation and the iodoform bandage were removed and the uund u was connected with Su gardyneTfi. The bandages were changed three times a day. At the on the fourth day the patient had a pure, healing ound with good levels of granulation. By the eighth day the patient had made good progress in healing with narrow serrations in the center of the uunde,

J | v |

power; the treatment with Sugardyne dressings, which were changed three times a day, was continued, Incidentally, through the mouth with hydrogen peroxide

BATH ORIGINAL 030044/0785

9Cleaned and cleaned. The uund was almost completely healed later, and in January 197 ¹ year it was completely healed. The patient had: normal feelings and normal colors with a very slight defect in the 'ing he pointed: in the sense of a total length.

Comment:

TIM

Treatment with Sugardyne resulted in the restoration the fingertip length, prevented one necessary skin transplantation, avoided antibiotics and left an oound that healed quickly. LJeiterhin uare the treatment costs significantly ye.ringer, than if other drugs had been used.

XIII. A 7-year-old, outside boy (Ü P) uurdp der underwent following treatment after himself pulled a bruise in a motorcycle accident had, (the fingertip of his right index finger). He was treated for 10 to 12 days and had a severe infection in his finger,

TPl including the end. He was with Sugardyne

treats the books three to four times The day was changed and the finger was cleaned with hydrogen superoxide. nearly complete healing was achieved a week later; after 13 days absolute healing without scarring was achieved.

XIU. A 61-year-old black man (GK) was treated for an injury in his left hand. It contained bruises and deep lacerations (one saw 1icQJ i ch tendons) of the index finger, the long finger and the ring finger. He was immediately treated with iodoform, first, and

Tf-I then with a whirling bath and finally with Sugardyne

030044/0785 _ba d ORIGINAL

3QU524

The bandages were changed twice on the day and with hydrogen peroxide. Almost complete; Healing took place with minimal l \ ia.rbenbildung, cr .. A full range of motion uar restored within four hours. The long and ring fingers were completely healed completed in less than two hours.

XU. A 5 year old white boy apparently fell and suffered from many abrasions on the right hand, the right side of his face and forehead. A day later he had an elevated temperature and his wounds were covered with pus,

Jf .;

They were connected to Sugardyne during his ounds. His mother changed his bandages twice a day and the patient had all of the G Hours (250 mg) of erythromycin to use. Two days later the patient was ound almost completely healed without any signs of infection or scars.

Comment:

The healing was quick. The patient complained Do not worry about pain during the entire treatment.

XVI. -A 41-year-old white male (RK) suffered a deep abrasion in his right shin, about halfway down to the bone. His uunde was infected with Mississippi River Uasser, as well as with mud. Was within two days it nobh polluted and infected. The treatment

TM was on the second day with Sugardyne bandages taken up, changed once a day and cleaned with hydrogen peroxide. The uunde healed quickly without further infection and covered with skin with slightly brownish losing skin Color, but with full feel and full hair coverage .

030044/0785 BATH ORIGINAL

Comment:

T Pl The case demonstrates the effectiveness of Su _y ardyne in Uu ηden with open, uncovered, infected bones and ueichem Geuebe and without accompanying use of antibiotics.

XUII. A 41-year-old, outer man, surgeon (RK), dor First and second degree burns on his left hand had by the explosion of a matchbox received on the volar and dorsal aspects that encompassed the base of the thumb, the palm of the hand that Dorsum of the hand and all four fingers. Immediate treatment

TM

with Sugardyne and a dry bandage had taken place. The patient was able to remove the bandages later, within four hours with complete decrease in First and secondary degree burns, including all small glasses. The pain disappeared immediately and the patient could go back to work immediately, including full hand use after four Hours. He is also able to operate the next morning without burns and pain.

Comment:

The case shows the double action in the sense of faster Healing and in the sense of eliminating pain

TFl acting patient. _It shows the effectiveness of Sugirdyne to give the patient the opportunity to get down to work straight away to return.

XVIII. A 63 year old outside man (AK) received one Shot in his right ankle in 1965, with the following fusion of the ankle. The patient had a constantly purulent ankle and this discharge resulted in a Staphylococcus aureus culture.

030044/0785

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tj τ »

Against the urination had to take antibiotics constantly, uelches normally after a while the swelling and oozing worked. The patient was treated with Sugardyne, (since June 1978) and already had a decrease in the number of inflammations. V / erm the inflammation

occurred, he already had through the use of

TPl
Sugardyne achieved rapid healing. He

normally the action begins as soon as he does

noticed the erythernatous areas; healing usually occurs within a day or two.

Comment:

This patient shows the effectiveness of Sugardyne

^In chronic osteomyelitis and also shows the effectiveness of this drug when compared with the normal result of antibiotics on the patient

XVIX. A 22-year-old white woman (EH) was in the emergency operation room after a car accident on August 5, 1978 treated after receiving many skin abrasions and lacerations and a deep laceration medial to her left knee. After cleaning, the deep lacerated wound was closed over a drain

T Pi ν e r - and the patient was on Sugardyne for two days

* Two days afterwards her wound healed without any sign of infection. On the sixth day her uund almost completely healed. Your Uunde healed afterward with minimal Viewing V _e rnarbungan in all abrasions and lacerations and e'e no keloid formation had. The dressings were changed twice daily during treatment.

BAD ORfQfNAL

0 3 0Ö4 U 07

Comment:

The patient could be treated without antibiotics and had an uneventful, uncured, comfortable one

T 1 * 1 maintenance through the use of Sugarayηe

XX. A 13-year-old from the outside world suffered a kiss and a fracture on its left part would bend η ^ a week before he was treated in the emergency operating room. He had an erythematous area in the lateral derich of the arch and fevered. He obviously had an early one Infectious rupture of the left elbow. The treatment with Cleansing Betadine completed cleaning and binding with Sugardyne. The patient was on Keflex (25U mg) set every 6 hours. In the days that followed, she disappeared Symptomatology of the patient and very much

the erythema diminished. The early infection healed completely within two days.

Comment:

This case shows the rapid lleilur.cj of infected Lacerations and open fractures from the use of

TI ⁷ I.
Sugardyne, used in combination with antibiotics.

XXI. A 35-year-old man of color (Cu ¹ ) was admitted to the hospital after his left arm was pierced through and through at the level of the bone. The patient's first treatment included an intravenous antibiotic and a pre-packaged solution

TM infection prevention. Then he was with Sugardyne in the Treated in hospital and also in outpatient treatment until the uund was clean enough to seal it with SuLura. That was done three! Yokes later, and it continued in its uneventful uneventful healing.

030.044 / 0785
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3QH524

- 14 8 -

Comment:

The possibility of infection in this necrotic ound was relieved by the use of sugaryne "and also by antibiotics. Üi-r P ₁ ^ a ti healed with minimal scarring and no infection. Many of these treatments are carried out on an outpatient basis.

XXII. A 54-year-old, white, lady (KLi) uurde due treated for a massive infection in her left leg. The infection resulted in a severe abscess, which on 5. Lurii had to be amputated in 1970. By the slow Her infection was resolved with Sugardyne

and treated with antibiotics, including one complete cleaning and granulation dos diitul Blunt led. She then underwent a revision of this amputation and was able to leave the hospital Dismissed £ days. After the end of the third week uar the stump healed completely, with not one single scar marks. Then she received an under-knee prosthesis and has had minimal problems since then. The bandages were made three times a day with Gugardyne changed. Antibiotics were given every 6 hours.

Comment:

A difficult problem carefully became in the middle ages

τ pi
handled with the use of Sugardyne, with a quick turnaround time, so that the process derr. Patients are helping to be more likely to be discharged from the hospital.

-The treatment has been greatly improved with this drug and the possibility for those dying of infections has been improved

TH was with simultaneous use of van Sugardyne and Avoided antibiotics. There has been no development in the treatment with Sugardyne

Q300U / CT7 85 BAD ORIGINAL

- i * q -

XXIII. A 54-year-old, ueißü, woman (MJ).; I: Li- il-> ■ ·. \ do a stitch abscess ζ, after uiner ÜpuraLion on her arm joint ο you uurde mi L Sugardyne 'and niL Κα Γ In χ (? LfJ never,) every sixth ELu η you treated. After that h t- i 1 L e: .iu - ^ uL c ti η c to leave any scars.

Ko mm e η La r: This lall shows L the use of v / an "juyardyncj Π ^ν Ι for a general problem after an operation.

XXIU. A 35-year-old, farbi _y er flam. (JK) uurdü injured on Hai 20, 197B while driving on his motorcycle. He suffered a lot of hau tabs chü rf uηgeη and even the upper Eχ Lremi LäLeη, including the shoulders, hands and hand bones (especially on the right side). The Uunden uurden in to tope ^ rationsraup treated. After a day they were covered with pus in large straps and appeared to be burnt. The uurden

TN

with Be tadi ^ n-l. Solution cleaned and connected with Sugardyne , Within two days the uund was clean Fresh granulation volume formed and no sign infection more. The uare almost entirely within Filled in a week and most of the items were perfect covered with normal black skin. Three days later the skin was nearly healed and covered with brown skin the previously injured Ceuebe. The Geuebe uar normal and with Feeling.

Comment:

The patient was able to return to Ilausa without infection and treat with a good end result, even though there could have been a very serious body infection.

His uunds healed with Sugardyne TfI without scarring and without loss of pigment. His treatment was stew-free.

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XXV. A 26 year old white male (J: ^V ! C) had received a dirty laceration in the midsection of the volar, his right forearm, which later became infected (despite being treated with antibiotics) about 5 days after the first treatment. The first treatment involved removing some sutures and treating the uund with iodoform. Two days later the uunde. which was ulcerated but not bleeding with

TN
Treated Sugardyne. It then healed in about 7 days, without any further infection and with minimal scarring. The patient bandaged his wound daily, used hydrogen peroxide to clean the wound, and sugardyne and a dry bandage.

Comment:

The patient was able to continue his work despite having a infected uunde. In this form it was quickly curable and without secondary pain.

XXVI. A 58-year-old, white, man (UMG) had it 1 ο years previously underwent a partial amputation of his right foot because he had diabetic gangrene. He had some foot ulcers which forced him to go to the hospital monthly for two to three years. During this time the patient had become dependent on pain pills. He was treated with various drugs containing both systemic and oral antibiotics and also bandages required to treat the ulcers.

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In general, uuchi him diu UiaLuLio u <, ui li.h l -.- ifil, the ulcers wunn get acutely infected and ui uuidu thereby lead to hospital;: u gbhen. "For years the patient has been using Sugardyne" for his daily dressing changes. He wipes off Uuride riiiL · soap, water and hydrogen peroxide before changing the dressing. During this time he did not have to go to the hospital any longer to take antibiotics, and he did He had done it in the past, his uiabutis has stabilized and he is completely frozen, which frees him from taking narcotics.

Come in cash: Ubuohl the patient's diabetes and his chronic ulcers have not yet healed, εα has

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he stabilized himself through Sugardyne Reached health as it is no longer necessary for him to visit the hospital and he his Has diabetes under control. He's from his i-narcotics addiction freed.

XXUII. A 29-year-old, ueißer man (CBD) uurde ₅ three or four days before he uurde seen injured. A large board fell on his ankle, inflicting an ueiche tissue injury on him, including a foot ν e ir; tai ichiinp ;. The patient

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later developed an abscess that was treated with Sugardyne. Dodo concluded the first treatment with a full bandage one that was removed after a day and a half and by that time some pus had formed, but no bleeding. Within four days of the first treatment, the uuηde was almost completely healed.

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Comment: The patient could be on am-bulantarn. UgCjü treated despite having a significant ankle injury would have. This also did not include the use of antibiotics. The patient was able to

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Sugaryne was easy to use and had no pain.

XXu ¹ III. A ten-year-old black dune had a deep fissure and contusion to the distal part of the right index finger, including a villus fracture, when a stone fell on him. The first treatment of the patient

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u was made with Sugardyne. The patient received a dressing change and an examination and examination in the PJot operation room. Within four days the mouth healed completely without any signs of scarring.

Comment: The case shows the rapid, uneventful healing with little hospitalization, without wasting Antibiotics, ease of use and minimal pain for the patient.

XXIX. A 2o-y [hers, white woman (SIl) uurde in an i \. alfa IJ.-

Operating room treated after being injured by c-ine ax

an open fracture of the middle phalanx, dec left long

Fingers received. You were initially with a

Long repositioning, internal fixation and suture of the

TPi ruptured extensor tendon treated with antibiotics and sugardyne

Dressing change after sewing the LJunde.

She healed quickly with no infection. Below she had minimal scars on the finger without keloid formation. Three l'ionate after the accident the fracture healed completely.

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Comment: A serious accident that led to my amputated finger could uüiden treated without hospital admission, it healed with Sugardyne Lithantll uni ^ without scarring. The patient was in dur I agu · :. I sulLur to treat you at home.

XXX. A 7-year-old, white 3unge (DL.) Suffered amputation (by an ax) of his forefinger and middle finger, his left hand. The patient experienced in e υ ^e B eiste cleaning treatment and stabilization of the finger with a M-rail. His patches had healed and the skin had closed, the bandages changed with Sugardyne. The patient went through an uneventful recovery process, with almost complete healing of the ounds within one week. There was no infection, as a result, the fracture was able to heal with no side effects. The patient had no visible scars.

Comment: The case shows a quick Hei Chin v "n contaminated, injured skin, including bones,

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without infection, with the use of Su gardyne 'as Main Uund-Uerbandsmittel.

XXXI. A 59-j ähriger Fleischer (hue), the distal his right middle finger (distal phalanx) amputated a third, υ 'i while he worked as Metzger, received a first treatment in Notoperations space. This treatment included

the stopping of blood from the gentle grass and bones end at the end of the amputated fingertip. The treatment

TM was done with Dodoform Mull, and after one day mut 3ugardyne * The bandages were changed twice a day after cleaning with hydrogen peroxide. The patient was completely healed in four weeks, with the restoration of about three-quarters of the lost ti η en G out be a ,, without skin transfer.

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He has feeling again and good pulp on the fingertips.

Comment: This case shows the recovery wan Üeuebu after a fingertip amputation, through the use of

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Sugardyne for daily dressing changes. No antibiotics were used, although the bones were exposed and exposed. The treatment was painless.

XXXII, A 10-year-old boy (JU) was treated on a two-inch splinter embedded in the sole of the foot. f \! ch ^a cleaning of the foot uurde the splitter un ter local anesthesia removed. Sugardyne was used to treat the wound and the patient was given oral antibiotics. The foot healed completely in two days, without infection and changing ligaments twice a day.

TR Comment: This F ₃ Il shows the effectiveness of Sugardyne

in contaminated soil, in the sense of preventing infection and quick healing. The Grail Antibiotic Keflex, administered every 6 hours.

XXXIII. A 16-year-old outside boy UurdG _; Injured 19 days before being viewed; the fourth and fifth fingers of his left hand were sprayed with liquid propane; the result was frost damage (full density - 3rd degree), particularly the middle part of his fifth finger. Both fingers were initially covered with blisters, although they had already been treated with Ustadin (PJ) solution, both fingers had become infected.

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Almost 2/3 dorsurnal the fifth finger infected, both PIP and DIP joints. On January 4, 1979, 19 days after the burial, the patient began using Sugardyne, up to three times a day. The Uunde sauter was within four with no indication of infection. On the five tu η day he boo ie π a, n Uundenrand a skin border won 1 / B-ZnIl .; 11 days ^ pritur uar the uund covered with skin more than 50 percent. Zuei Uochen later the uund healed completely, without scars. Of the Pa ient could bend all of his finger joints in one full range of deflection.

Tl ^v i Comment: This case shows the effectiveness of Sugardyne in schuierigen burns, overlapping skin folds. Fast Healing, obuohl it was treated ^{V (^} ur with PI solution uelches 3 Uochen ineffective / uar.

XXXIU. A 15-year-old outer dungeon (K) suffered from an open fracture of his right tibia, with protruding bones protruding from the skin, while riding a bicycle on July 24, 1978. Irrigation and debridement were performed in a surgery room ; they received stabilization with K-wires ⁺ and Hins · ui- ^B uunde uurde closed

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over a drain and was later treated with Suryardync _? 3 times a day. Within 16 days the Uundc- completely healed without infection. The patient was not given any antibiotic for seven days. The recovery was uneventful without osteomyelitis.

+) K-wires, K-Wirüs or Kirschncr DrJHi t ti are wires made of stainless steel to Stnbi Ii siurunp, vnr, FraM.uren and zu joining them together by exercising Zup. She; will from the company V. Müller Division οΓ American Hospital Supply Company.

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Comments: This case shows an open fracture,

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which has been successfully treated with Sugardyne.

XXXl /. A 15 year old outside ounge suffered from one contaminated fracture of his right tibia. He was treated with in an operating room Irrigation and debridement of the open wound,

with closure _A which lies loosely over a drain. They received a stabilization of the fracture with a K-splint and impression. Further treatments, including taking the drain and antibiotics. On the third day he was given SugardynE and the wound healed without infection. The bone healed as usual.

Comment: The case shows the effectiveness of Sugardyne in open fractures. The uunde was healed quickly and without infection of the fracture and without scars.

XXXUI. A 13-year-old colored boy who was on one treated a large abscess on his left knee. He had suffered from a knee injury for three weeks, from one Accident caused. The injured area developed to a 3-inch χ 4-inch abscess. The abscess was underneath local anesthesia on February 27, 1979. Great Lots of eggs were secreted from the abscess, including some Iodoform and then uurdo treated with Sugardyne TR. Of the Patient spent a day on the weekend

in the hospital to expand the treatment to the almost complete. Resolution of the ex _sz esses uurdc in four days reached.

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The almost complete healing was. · In se ^ hs Days reached. The patient received a full ^^ IHvfc * » constant renewal of the fabric without loosing it of the abscess.

TFi Comment: This case shows uie helpful sugardyrie

'To draw pus from the wounds (or abscesses). It also shows the use of this drug in the complete, rapid healing of the wound.

The invention and its advantages can be readily understood from the foregoing description. Different Changes can be made in the manufacture and in the combination without departing from the actual idea of the invention . . deviate and without giving up the other advantages,

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Claims (15)

B 25 - 6 Note: Richard A. Knutson 130 NorLh Shelby Street (or) P.O. Box E33, Greenville, Mississippi 38701, USA Title: Wound Healing Claims: 1) wound healing agents, d a d u rc h g e k d η η ζ e i c h η e t, that it is essentially homogeneous and that it has the following ingredients contains: a) 10 to QO parts by weight of an antibacterial guweb nutrient, b) 1 part by weight of effective fugicidal / antibacterial Means that physically, chemically and pharmako 1 op, isch is compatible with a), and c) a sufficient amount of carrier subs I .inz that the Mixture gives a consistency in which the agent can simply be applied to a sponge or gauze and in which it remains at the point of application when it is applied directly to the tissue of an open wound or a burn wound and this carrier substance both with a) and with b) physically, is chemically and pharmaceutically acceptable and its amount is no more than one third of the weight of the wound healing agent amounts to. 030044/0785 BATH ORIGINAL 3UI4624 2. Wuntlheilmi ttel according to claim 1, characterized in that that the component consists of sugar, glucose, dextrose, fructose, honey and / or molasses. 3. Wundheilmifctel according to claim 1, characterized characterized in that component a) is commercially available granulated sugar. 4. Wound healing agent according to claim 1, characterized in that dsr component b) is ^D avidon iodine [polyvinylpyrrolidone - 3od complex]. 5. wound healing agent according to claim 4, characterized in that component a) 25 to ti 5 Is parts by weight of commercially available granulated sugar. 6. Wound healing agent according to claim 1, characterized in that it can be stored for a long time Component a) is commercially available granulated sugar. 7. wound healing agent according to claim 6, characterized in that that there are 20 parts by weight of component a), 5 parts by weight Betadine ointment (see page 5) and 2 parts by weight of Betadine solution [see page 5). 8. Wound healing agent according to claims 1 to 7, characterized characterized in that component c) is water-soluble is. 9. Wound healing agent according to claims 1 to B, characterized characterized in that Bertandteil b) is water-soluble. 030QU / 0785 BATH ORIGINAL 30H524 10. Wound healing agent according to claims 1 to 9, characterized in that the component a) sugar and components b) and c) are water-soluble. 11. Wound healing agent according to claim 10, characterized characterized in that it contains between 25 and 55 parts by weight of component a)., during the Component b) Povidone iodine (polyvinylpyrrolidone iodine complex) is. 12. Wound healing agent according to claims 1 to 11, characterized characterized as being substantially non-allergenic. 13. The application of the wound healing agent according to the claims 1 to 12, due to the fact that after cleaning the wounds with hydrogen peroxide is carried out by applying the wound healing agent to the wound. 14. The application of the wound healing agent according to claims 1 to 12, for an open wound with non-bleeding tissue, characterized in that the Wound healing agent is used in an amount sufficient to cover the injured tissue. 15. Wound healing agent according to claims 1 to 12 for the treatment of non-bleeding tissue of an open wound, characterized in that the component a) sugar, the component b) povidone-iodine (polyvinylpyrrolidone-3odic complex ) and the component c) is water-soluble. V / Bo 030044/0785