CH653892A5 - Wound medication for covering wounds and burns. - Google Patents

Description

The invention has for its object to provide a wound healing agent, the effect of which is considerably improved compared to the known agents and which is particularly easy to use. In particular, the aim of the invention is:

1. To provide a mixture that inhibits the growth, reproduction of bacteria and fungi where they are contacted and kills the bacteria and fungi.

2. Deliver a microbicidal, antibiotic mixture that, when used as a wound dressing, leaves a clean, debrid wound.

3. Deliver a mixture that is consistent and allows direct use in open wounds and in conjunction with dressings in open wounds and burns.

4. To provide a mixture that is stable, durable and temperature resistant with respect to separation or crystallization, or finally, e.g. B. only after stirring before use, is suitable for use with a predictable effect.

5. To deliver a mixture that cleans the contacted tissue so that a forming, granulating tissue can be embedded.

6. Deliver a mixture that aids in the formation of overgrown tissue granulation in a clean environment.

7. Deliver a mixture that aids in epithelial formation around the edges of the wound, while the granulation tissue fills the damage without crusting or scabbing.

8. To provide a mixture that completely or almost completely covers the wound with skin.

9. To provide a finished, ready-to-use mixture which serves as a) antibiotic and antifungal agent, b) as food for the granulation tissue and c) as support for the skin covering.

10. To deliver a mixture which serves as local anesthetic and thus avoids the use of anesthetic agents.

11. To provide a mixture that reduces or eliminates the growth of wound tissue in gauze or similar dressings.

12. To deliver a mixture that supports tissue regeneration.

13. To provide a water-soluble and washable antimicrobial product that has a gentle and somewhat granulating texture and is used directly on wounds and burns, promotes faster healing with minimal scarring, easily adheres to dressings and inhibits the growth of tissue granulation into the dressings .

14. To provide an economical blend that is effective in treating wounds of all types and can be used on humans and animals.

15. Deliver a uniform mix so that non-separate components must be applied to the wound and / or the dressing material.

16. To provide a medicinal mixture that can be used directly on the wounded tissue and remains stable there.

17. Provide a medical mix that is easily applicable either directly to the wounded tissue or to bandages without the risk of spillage or accidental escape from the area of application.

18. To deliver a medicinal blend of consistent quality that maintains its properties and, when used correctly, will produce predictable results.

19. To provide an essentially non-drying medical mixture that does not become hard and therefore does not stick to the wounded tissue to which it is applied.

20. To provide a consistent, medicinal mix that is easy to use, does not flocculate, and does not degrade in any other way.

21. To deliver an essentially homogeneous mixture for the treatment of burns and open wounds that is widely accepted by patients.

22. To provide a medicinal mixture that remains in place when applied directly to wounded tissue and can be easily removed at a later time without damaging the tissue.

23. To provide a mixture for the treatment of open wounds that has a long shelf life, has a cleaning effect and healing properties and therefore reduces the frequency of dressing changes to a minimum.

24. To deliver a gentle and mild medicinal mixture that can be applied to the wounded tissue with minimal irritation, if any.

25. To provide a medicinal mixture that allows for complete and even coverage of the wounded tissue.

26. To deliver a mixture that has a cooling analgesic effect on the wounded tissue to which it is applied.

27. To deliver a mixture that enables the even, controlled application of sugar substances and fungicidal / antibacterial substances in direct contact with the wounded tissue, the contact regarding these two components being predictable and constant.

28. To deliver a wound healing mixture that promotes the formation of the healing tissue so that firm granulating tissue is created which continues to build up and become surface tissue as the wound heals.

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29. To provide a wound-treating mixture that has an improved, debride effect and reduces scab formation.

30. Deliver a wound-treating mixture that can be easily applied by patients themselves with minimal instructions.

31. To provide a mix that patients can readily bandage the wounds to as prescribed.

32. To provide a wound-treating mixture that allows the wounds to remain essentially odorless.

33. To provide a wound-treating mixture that is effective immediately upon application, without following the necessary "sterile" conditions and therefore a substantial reduction in the cost of dressings and the associated materials and the time required to apply and change the dressings .

These tasks are solved by the wound healing agent according to the invention. The invention relates to a wound healing agent which is characterized in that it is essentially homogeneous and contains the following constituents:

a) 10 to 80 parts by weight of an antibacterial tissue nutrient,

b) 1 part by weight of active fungicidal / antibacterial agent which is physically, chemically and pharmacologically compatible with a), and c) a sufficient amount of carrier substance which gives the mixture a consistency in which the agent is simply applied to a sponge or gauze and in which it remains at the place of use if it is applied directly to the tissue of an open wound or a burn and where this carrier substance is physically, chemically and pharmacologically compatible with both a) and b) and its amount is at most one third the weight of the wound healing agent.

Further embodiments of the wound healing agent according to the invention and its use result from the dependent claims.

The wound healing agent from b) fungicidal / antibacterial agent such as povidone iodine, a) antibacterial tissue nutrients, e.g. B. Sugar (which itself is a strong antibacterial agent in high concentration and stimulates tissue granulation, and c) a suitable carrier in the correct proportion, is a stable, effective antibiotic composition that facilitates the healing of wounds on which it is applied directly. It prevents the granulating tissue from growing into the dressings covering it and also fulfills the tasks mentioned in the beginning in every other way.

The fungicidal / antibacterial agent is one which is preferably compatible with sugar. It is preferably water soluble which facilitates its handling and removal from the tissues to be treated.

It is preferably non-allergenic, so that there are hardly any limits to its use. Povidone iodine meets all of these criteria. It is a fungicidal / antibacterial agent of special quality and was used throughout in the application examples mentioned below. However, fungicidal / antibacterial agents which are compatible with sugar and are therapeutically suitable for use in open wounds can also be treated with sugar, e.g. B. cane sugar, dextrose, maltose, fructose, honey and / or molasses can be combined.

Povidone iodine is preferably in the form of Betadine ointment (10% Povidone iodine) and Betadine solution (10% Povi-

don-iodine) is used. These substances are defined on page 5. Since these substances already contain suitable carrier substances, a separate addition of carrier substances is not necessary. On the other hand, the fungicidal / antibacterial agent can be mixed with sugar and any (preferably) water-soluble, neutral, physiologically acceptable ointment base, e.g. B. Unibase and possibly water (to reduce the viscosity) or z. B. carboxymethyl cellulose (to increase viscosity) can be combined to obtain a suitable consistency and stability. Of course, other ointment bases such as petroleum jelly can be used if water solubility is not required.

"Unibase" is an oil-water emulsion from Parke Davis with the following composition:

Methyl paraben 250 mg

Propyl paraben 150 mg

Sodium lauryl sulfate 10 g

Propylene glycol 120 g

Stearyl alcohol 250 g white petroleum jelly or paraffin oil 250 g purified water 370 cc

Suitable as sugar is the one that can be bought in any grocery store and it is not necessary to specially clean it, sterilize it or treat it in any other way. Although sucrose is preferred because of its lower cost and easy availability, it can be partially or completely replaced by dextrose, maltose, fructose, honey, molasses or similar substances with a high sugar content.

All of the sugar mentions mentioned here include, optionally (individually or in any combination), each of the abovementioned substances, and all of the exemplary embodiments are based on commonly used granulated sugar.

The quantitative ratio of sugar to e.g. Povidone iodine is significant from a cost standpoint, ease of use and effectiveness. If the povidone iodine is present in the form of betadine ointment and betadine solution, the weight ratio of sugar to betadine ointment suitably varies from 1: 1 to 8: 1, the amount of the betadine solution gradually increasing, from 0 for the 1: 1 ratio, to 0.5 ounce per pound (0.03123 grams per gram) for the 2.5: 1 ratio, to 1 ounce per pound, for the 4: 1 ratio, to 2 ounces per pound for the Ratio 8: 1, (based on the total weight of sugar and betadine ointment).

For a longer shelf life, it is advantageous to limit the ratio to 2.5: 1 to 5: 1. In this range (from 1: 1 to 2.5: 1), the ingredients tend to separate, but are easily mixed again by briefly stirring before use; above this ratio (from 5: 1 to 8: 1) the components tend to separate and crystallization takes place.

The preferred recipe is based on 20 parts by weight of sugar (sucrose), 5 parts by weight of Betadine ointment and 2 parts by weight of Betadine solution. This corresponds to 100 parts by weight of sugar, 3.5 parts by weight of povidone iodine and 31.5 parts by weight of vehicle. If the components are mixed in this ratio, there is no separation of the components and the agent maintains its consistency, both in hot and cold, thus ensuring durability over a long period of time, it is also easy to apply and is particularly popular with patients. In addition, these quantitative ratios were determined by experiments with a large number of quantitative ratios of the constituents mentioned and the stated quantitative ratio was found to be the best, not only for the preparation of the mixture, but also for the s

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Effectiveness of the product in relation to the various wounds and the treatment for which it was used. That is, a sugar content of about 70 to 80 percent by weight (based on the total weight of the mixture) appears to be the optimum for wound healing. This is almost the same as the concentration of sugar and honey.

Although sugar or sucrose, povidone iodine and carriers which are used in betadine ointment and betadine solution are often mentioned, these are only a few illustrative examples of the preferred embodiment. The substance composition is not limited to this.

Instead of sucrose, any high concentration, antibacterial agent that promotes tissue granulation may be used, such as other sugars and sugary components such as fructose, glucose, dextrose, maltose, honey, molasses, or any combination of these.

Normally, table sugar is preferred because of its availability and cost-effectiveness. If honey, molasses or a similar liquid substance is used instead of sugar, the proportion of the separated carrier substances is either reduced or the carrier substance is omitted. This component is usually referred to in this text only as "sugar". In addition, the composition of the agent is not limited to those in which povidone iodine is the fungicidal / antibacterial component. This can be replaced in whole or in part by one or more components with similar and / or related properties. The components are either insoluble or only dispersible in water. However, water solubility is preferred. The ingredient could be an antibiotic, but better not. It would be ideal if it were not allergy-causing. The following are mentioned as examples of substances that contain all or at least some of these components:

Acrisorcin = 9-aminoacridine 4-hexylresorcinolate amphotericin B

Anthralin = 1,8,9-anthracenetriol candicidin

Dibromopropamidine isothionate

1,3-di (4-amidino-2-bromophenoxy) propane di-2-

Hydroxyethanesulfonate domiphene bromide fluorouracil gentian violet griseofulvin

Haloprogin = 3-iodo-2-propynyl 2,4,5-trichlorophenyl

Hexachlorophene

Ichthammol (shale oil sulfonate)

Iodochlorohydroxyquin = 5-chloro-7-iodo-8-quinolinol

Iodoform (triiodomethane)

Nitrofurazone

Nystatin

Povidone iodine

Resorcinol

Sulfabromomazine

5-bromo-4,6-dimethyl-2-sulfanilamidopyrimidine 10-undecenoic acid and / or its zinc salt

In order for the mixture of sugar and fungicidal / antibacterial components to have the desired consistency, one or more carrier substances are normally required. The following list shows substances that are suitable as a carrier or from which the carrier can be composed.

Agar

Cold cream corn oil

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Cottonseed oil gelatin glycerin hydrophilic ointment s hydrophilic petrolatum lanolin methyl cellulose io olive oil peanut oil pectin

Polyethylene glycol 400 Polyethylene glycol 600 15 Polyethylene glycol 1,500 Polyethylene glycol 4,000 Polyethylene glycol 6,000 Povidone

These are common and generally recognized substances that are regularly used in the formulation of topical ointments and pastes. They are used in the usual way and mixed with the sugar in such a way that a product is obtained which does not flow but has such a consistency that it can be applied while maintaining its cohesion. The mixture expediently contains no volatile constituents, the volatilization of which could lead to a change in the consistency of the mixture if, for example, a vessel in which the mixture is located remains unsealed. 30 The fungicidal / antibacterial component must be physically, chemically and pharmacologically compatible with the sugar or the sugar-containing component. Even if a separate carrier substance is used, it must also be physically, chemically and pharmacologically compatible with the first two necessary components.

The wound healing agent according to the invention makes a significant advance over the known use of sugar and betadine solution, not only 40 in terms of patient acceptance and convenient use in a wide variety of wounds, but also in relation to the mode of action of the Means. Before the introduction of the wound healing agent according to the invention, it was repeatedly found that the tissue in 45 wounds grew so quickly that it showed a tendency to adhere to the dressing material, so that the healing process was disrupted when the dressing was changed. This disadvantage was completely eliminated by the use of the wound healing agent according to the invention.

The careful mixing of the various components has been worked out over a longer period of time in order to maintain the current recipe. After repeated attempts, it was found that it is particularly effective and safe. It has been used successfully in a variety of health-promoting, both surgical and non-surgical treatments and in many wound situations in practice in physical therapies and in hospitals. In many cases

that it is completely effective in healing various wounds without the need for further surgery, skin transfer or additional antibiotics.

In the past, special problems were encountered in the treatment with sugar in connection with Betadine solution, more often in the treatment of amputated fingertips than 65 in the treatment of deep wounds, since the fingertips healed so quickly that the granulating tissue tended to do so to grow into the dressing material. This caused considerable difficulty in removing propylene glycol colloidal silica

Sodium alginate

Sodium carboxylme

ethyl cellulose cellulose

D-sorbitol solution

Whale seeds

Strength

Stearic acid

Stearyl alcohol white ointment white petrolatum yellow acid

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dressing and was often associated with considerable pain for the patient. Although tightly woven silk or nylon bandages limited this problem, they tended to inhibit the proliferation of tissue granulation and thereby prevent the healing wound from fully restoring to its previous condition.

The wound healing agent according to the invention is not only an improvement, it also reduces the growth of the tissue with the dressing material, while the positive properties of sugar and betadine solution are retained, but is also easier to apply and uniform in its consistency. In the past, the individual components were applied in different ways. Spills of betadine solution and sugar occurred during use and caused contamination. After application, the individual components tended to dry out, the sugar crystallized and tended to disappear from or through the dressing.

Countless attempts have been made to create a mixture of sugar and povidone iodine that should adhere to the dressing and not flow away from the tissue or dressing, the handling of which did not result in contamination and not sticky with a sticky mass filled bandages.

Each addition resulted in a reduction in the amount of sugar that came into direct contact with the wound. Premixed preparations of sugar with povidone-iodine solutions segregated after a very short period of time, with the sugar depositing on the bottom and a syrup consisting of povidone-iodine solution and sugar. Povidone-iodine ointments with at least 50% by weight of ointment base also separated and were sticky, sticky and greasy, while formulations with more than 80% by weight of sugar tended to granulate and lose connection, making it difficult to to apply them and they did not adhere to the dressing. In the wound healing agent of the invention, a sugar / povi-don iodine ratio of 3.5: 0.1 to 4: 0.1 was found, the povi-don iodine being in the form of a 10% by weight ointment very cheap. This ratio range results in optimum wound healing properties, safety and economy.

The above ranges and ratios relate to the mixing of sugar with various combinations of Betadina ointment and Betadine solution because these povidone iodine products are easy to obtain. If the wound healing agent is made from 20 parts by weight of sugar, 5 parts by weight of Betadine ointment and 2 parts by weight of Betadine solution, so that it is essentially homogeneous, it is particularly effective, very economical, temperature-resistant and durable. The resulting ratio (20: 0.7) of sugar to povidone iodine is only limited by the nature (consistency) of the carrier substances used for betadine ointment and betadine solution.

Other carrier substances (used alone or in the correct combination) produce comparably stable mixtures with sugar / povidone-iodine, weight ranges from 10: 1 to 80: 1, preferably from 25: 1 to 55: 1. Since povidone iodine is water-soluble, water-soluble carriers are preferred, but are not essential. The consistency of the sugar / carrier mixture is important. If the consistency is similar to that of the above mixture, an appropriate amount of povidone iodine is included to produce a homogeneous product that has the desired sugar to povidone iodine weight ratio. A carrier is selected so that the sugar makes up% or more of the final product (including the carriers) to provide the desired concentration of sugar which is brought into direct contact with the tissue to be treated. By selecting water-soluble carrier substances of different consistency and different sugar concentrations, stable mixtures are obtained. The addition of the proposed amounts of povidone iodine to a stable mixture of sugar / carrier substance has no significant influence on the consistency or the stability of the mixture.

Suitable pharmacologically recognized water-soluble carrier substances are known and their particular selection or combination is not the subject of the invention. The carrier substances, which are also used for betadine ointment and betadine solution, can additionally be used with a greater or lesser concentration of povidone iodine.

If the povidone-iodine concentration is increased to 20% by weight in both, the wound healing agent (according to the stated composition) has a sugar / Povi-don weight ratio of 20: 1.4, if in both it is 20 5% by weight. -% is reduced, the wound healing agent has a sugar / povidone weight ratio of 20: 0.35.

If the viscosity of the mixture of sugar and carrier is too low, a small amount of a viscosity-increasing agent, e.g. Carboxymethylcellulo-25 se, can be added. Agents like this also contribute to the stability of the mixture.

Although a stable homogeneous mixture is preferred and is indicated here, less stable mixtures offer many of the benefits mentioned and most of the therapeutic properties as long as a high sugar concentration is in contact with the surface of the wound. If the wound healing agent is mixed to a substantially homogeneous consistency prior to use, if it adheres to gauze gauze or a similar material and if it remains in the area of the wound to which it was applied, then it is clearly a wound healing agent according to of the invention, even if it tends to separate in a vessel after standing for a few hours.

40 Care must be taken to ensure that the wound healing product is manufactured in a clean environment and in clean equipment. The use of stainless steel mixers and spatulas is recommended. The wound healing agent is packaged in opaque plastic containers, which are cleaned in the dishwasher beforehand and sealed airtight after filling.

To produce the wound healing agent, for example, 453 g of povidone-iodine solution (10% by weight), such as betadine solution, and 2,268 g of povidone-iodine ointment (10% by weight), such as betadine ointment, are placed in a container made of stainless steel Given steel with a capacity of 18.927 liters. Mixing is done with a sheet of stainless steel, driven by a motor with an output of Vi PS and using a reduction gear, which is intended for the production of 55 pizza dough. When the mixture has reached a uniform consistency, 9,072 g of sugar are slowly added until the batch has a uniform consistency.

The devices and the mixing devices are made of rust-free steel in order to exclude or reduce the possibility of contamination of the wound healing agent by softer metals, such as aluminum. All utensils, including the mixing bowl and stirrer, the stainless steel spoon and the filling container 65 are washed with water and soap before use.

If the mixture is uniformly consistent (usually after 10 minutes), the batch is weighed in clean, 0.5683 1 plastic containers. These are difficult

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translucent. After they have been weighed, the containers are tightly sealed and labeled with the date when the batch was made. The product retains its consistency over a period of more than 6 months when stored.

There are two basic techniques for applying the wound healing product to the wound. If the wound is deep, the medicine is spread directly on the wound and then covered with a 10.16 x 10.16 cm gauze cushion or other suitable dressing material. The wound healing agent sticks to the wound and makes it easier to apply the dressing material. The more general technique is to apply the wound healing product directly onto a 10.16 x 10.16 cm gauze pad as if you were spreading peanut butter on a slice of bread. The gauze pad is then placed on the wound with the medicine side down. This method is more effective when bandages are applied to burns and other flat wounds.

This means that the medicine is applied to the wound in such a way that it completely covers the injured surfaces. Typically, the wound healing layer is 0.635 cm thick. How often the dressing should be changed depends on the condition of the wound. In the case of highly contaminated (purulent) or oozing wounds, the dressing should be changed every 4 to 6 hours; while other wounds require less dressing change, sometimes only once or twice a day.

It is beneficial if the dressings are changed three to four times a day. Since the development of tissue progresses faster with fingertip amputations, these dressings should be changed a little more often. At every dressing removal, the residues can easily be washed off with tap water or, if desired, in a whirlpool. In about 50% of all cases, it is helpful to clean the wound with hydrogen peroxide before the wound toilet, and this may be necessary up to once a day for some wounds.

The wound healing agent tends to increase wound bleeding if applied to bleeding wounds within 24 hours of the injury. For this reason, iodoform is generally used first for hemostasis after cleaning or the wound toilet, and the wound healing agent is not applied before the following day or before the bleeding has stopped.

When the wound stops bleeding, the wound healing agent is applied as indicated above and the dressing is changed several times a day.

When epithelial tissue forms, a ring of white tissue sometimes appears between the growing tissue and the granulation tissue. Then a debridement is usually carried out at this point once or twice a day in order to achieve complete skin coverage without indentations or other defects occurring in the area of the wound.

Repeated, daily dressing changes continue until the wound has healed. The healing time is different. It depends on the type and depth of the wound. But all wounds treated in this way are good and healed relatively quickly.

The wound healing agent according to the invention in a composition of 20 parts by weight of granulated sugar, 5 parts by weight of betadine ointment and 2 parts by weight of betadine solution (US tool “Sugardyne”) was helpful in a large number of wounds, both in infected ones as well as non-infected. Infected wounds were contaminated with Staphylococcus aureus, E. coli and Pseudomonas aeruginosa, both combined, and many other bacterial species. Successfully treated wounds included abrasions, older lacerations and gunshot wounds and shotgun bullet wounds, both minor and major injuries to soft tissue, and injuries due to open fractures. Other injuries treated were spider bites with subsequent necrosis, first, second and third degree burns, frostbite, open bone fractures, decubitis, pressure, diabetes and stasis ulcers. However, the wound healing agent was unsuccessful in treating poison ivy and poison oak poisoning unless the patient had chafed the adjacent skin and it was infected.

Some success has been achieved with psoriasis; there is a tendency for psoriasis wounds to heal. A severe 15 carcinoma on the skin of a 98-year-old patient quickly reduced its size.

The wound healing agent has shown exceptional efficacy in treating a wide variety of common and rather unusual wounds in Men-20, in which bacterial and fungal contamination has usually occurred. There is an extremely high success rate with quick healing, reduced hospital time for patients and reduced time spent in the burn department, and faster patient discharge. There is a big improvement in the end results, through faster healing and the elimination of further surgery, including skin transfers.

In cases where skin transfers were required, the injuries inflicted on the donor were treated with the wound healing agent. These areas healed without scarring and it was difficult, if at all, to determine that they had served as the donor site.

35 The wound remedy has not only been shown to be an effective remedy, but has also reduced the need to administer drugs that are addictive due to its anesthetic effect. In the past, many patients would normally have asked for an anesthetic medication before or after changing the dressing. This has been minimized by the wound healing agent. This is particularly the case when the patient has large open wounds, including painful burns, where the use of any local medication is uncomfortable.

Therefore, in addition to wound healing properties, the wound healing agent has helped to reduce the possible dependence on narcotics, which can occur particularly in patients who are treated with it for a long time, so for the most part, wounds treated in this way healed without scars or with minimal scar formation. The wounded area was left with normal colored skin and sensitive and there has been no recurrence of infection or production of bone marrow inflammation in any patient to date. In many cases, antibiotics were not used or only used in small doses when the wound healing agent was used. In many cases, the wounds treated were the worst the inventor has ever seen and they have healed well. More than that, even with 60 deep wounds, hair grew back on the healed tissue surface. Regardless of bacterial or fungal contamination, the wounds healed successfully. This was true where all other products used failed and where all antibiotics used were ineffective. This was true when the 65 admixture was applied in an "non-sterile" form and without considering "sterile" procedures.

The wound healing remedy is an effective medicine that has been used and helpful in the treatment of:

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1. Skin abrasions (infected and non-infected)

2. abscesses (pus bumps / boils)

3. Acne (infected and non-infected)

4. Burns (infected and non-infected)

a) general burns

First degree

2nd degree

Third degree b) other burns

1. due to electricity damage

2. by chemicals (acids, alkalis and others)

3. Frictional injuries (ropes, plasters)

4. Sunburn

5. Carbuncle (weeping and festering)

6. Skin cancer (infected and non-infected)

7. Crushes due to accidents - reduction of tissue, edema

8. Means for debrigement of necrosis tissue (Brown Recluse spider bite, infected and non-infected)

9. Deep wounds (infected and non-infected)

10. Wound rose

11. Exposed bones (infected or non-infected)

12. Panaritium (only after incision and secretion)

13. fingertip amputation (large and small) (infected and non-infected)

14. Fracture blisters (infected and non-infected)

15. Frost damage (infected or non-infected)

16. Tissue necrosis (infected or non-infected)

17. Gunshot wounds (infected or non-infected)

18. Crack wounds (infected or non-infected)

19. Wounds open to the bone (infected and non-infected)

20. Bone marrow inflammation

21. Nail fold panorama

22. Perinal abscesses

23. Cysts in the hair area (infected or non-infected)

24. Postoperative dressings (infected or non-infected)

25. Psoriasis wounds

26. Shotgun wounds (infected or non-infected)

27. Suture abscesses

28. Amputation stump and guillotine amputations (infected or non-infected)

29. Ulcers (infected or non-infected)

a) decubitus ulcer b) diabetic ulcer c) pressure ulcer d) stasis (trophic)

To date, no attempts have been made to treat injuries to the eyes, ears, nose, throat or genitals and the wound healing agent has not shown any particular effectiveness in the treatment of viral diseases, poisoning with poison ivy or poison oak. But it was effective in treating all wounds, even if they were contaminated with bacteria, fungi, or both. It was effective against both gram-positive and gram-negative bacteria.

The wound healing agent in the form of an essentially homogeneous mixture of 10 to 80 parts by weight of a suitable sugar (antibacterial tissue nutrient) or constituent containing sugar, a part by weight of a physically, pharmacologically and chemically compatible fungicidal / antibacterial active ingredient which is pharmaceutically suitable for direct application to the tissue of open and deep wounds, and a maximum of 33 lh% by weight, based on the total weight of the wound healing agent, of pharmacologically suitable, physically, chemically and physiologically compatible carrier substance, which is sufficient in quantity and physical properties, the wound healing agent

Giving consistency that allows the wound healing agent to be easily wiped onto a gauze pad or gauze dressing so that it adheres and stays in place when applied directly to the tissue of an open wound or burn is easy to apply. After the wound is cleaned with water or hydrogen peroxide, the medicine is usually applied to a 10.16 x 10.16 cm gauze pad with a spatula or knife, and the gauze pad is then placed on the wound with the medicine side down (directly on the mesh). Alternatively, the medicine is applied directly to the wound and then covered with a gauze pad.

The wound healing agent in the composition of 20 parts by weight of granulated sugar, 5 parts by weight of Betadine ointment and 2 parts by weight of Betadine solution (US-WZ Su-gardyne) can be easily stored. Even after a longer storage period, it does not separate, regardless of whether it is stored at normal room temperature, in a warm room or in a refrigerator. Samples have been stored for more than six months under these conditions without separation or contamination. There has been no failure or reduction in efficacy despite manufacturing and storage under non-sterile conditions. Cultures were always negative.

The wound healing agent was applied to most wounds in a non-sterile manner without causing harmful results. Each of its components and the wound healing agent itself are water-soluble and do not permanently pollute the skin or clothing. If discoloration occurs, it can be easily removed with water and a mild detergent.

The wound healing agent does not cause pain when used. Most patients experienced rapid pain relief after application. When applied to a burn it creates an almost anesthetic feeling immediately after application. A few patients have reported a slight feeling of heat after application of the wound healing agent, rarely a feeling of pain is reported. The feeling of heat described is short-lived and no patient has reported such discomfort that the use of the wound healing agent had to be stopped.

The wound healing agent prevents new tissue from growing into the dressing material, while promoting the growth of the granulation tissue. This makes it easier to change the dressing without disturbing the healing of the wound and without causing pain to the patient. If it is absorbed, it is converted and not excreted. There is no evidence that this absorption is harmful. If sucrose is hydrolyzed from the tissue fluid and bacterial enzymes on the wound surface, the absorbed substances would be glucose, fructose and / or their transformation products.

In contrast to sodium chloride, these substances are metabolized and not excreted as such by the human body. Therefore, the absorbed products do not constitute potential cardio-vascular-renal problems for older people with heart or kidney diseases. Furthermore, there is no evidence that the product is diabetic, neither in diabetics nor in non-diabetics. No harmful effects could be found after the application of the wound healing agent, apart from the aforementioned bleeding promotion when applied to fresh bleeding wounds, which can be prevented by the precautionary measure described above.

Where a comparison was possible in one and the same patient, the wound healing agent has all other medications

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that are commonly used to treat similar wounds. These drugs include to Silvadene, iodoform-gauze, xeroform-gauze and, when used alone, to povidone-iodine ointment and povidone-iodine solution.

Silvaden Cream is an ointment from Marion Lab. Inc., Kansas City Missouri, USA, with the following composition:

Silver sulfazidine (1%) finely divided in a hydrophilic base made of white petrolatum, stearyl alcohol, isopropyl myristate, sorbitan monooleate, polyoxyl 40 stearate, propylene glycol, water and 0.3% methyl paraben as a preservative. Xeroform is a powder with tribromophenol bismuth.

Comparisons showed that most burns and wounds that normally form crusts (scabs) were developed by most other products while the wound healing agent stopped them. The result is a very clean, fast-granulating wound, achieved in a short time, generally in 1 to 3 days. Although the use of the wound healing agent generally reduces the need for skin grafts, wounds that require it can be treated earlier. Furthermore, most other products require the concomitant use of antibiotics. This was not normally necessary when using the wound healing agent.

The hospital time in the cremation ward is reduced when using the wound healing agent because the burn wounds quickly transform into clean, healing, uncontaminated wounds.

Since there are no contamination problems,

the burn patient can be treated with water whirlpools and multiple dressing changes outside the incineration station. Not only are the patients released from the cremation station earlier, but, like patients who do not suffer from burns, they are largely released from the hospital sooner.

The wound healing agent was particularly helpful in the treatment of diabetics who would normally have to undergo amputation after the development of a diabetic ulcer on the foot. Medicine achieved quick healing of diabetic ulcers, good results,

also given rather large contaminated ulcerative areas, including osteomyelitis below the ulcer. It also had fairly rapid cures for underlying osteomyelitis, although in many cases no antibiotic was used or was less effective, according to laboratory tests.

To date, there has been a reduction in the number of amputations to diabetics because the early diabetic ulcer, even with underlying osteomyelitis, usually reacts quickly to treatment with the wound healing agent. Wounds on extremities (especially fingers and toes) of non-diabetics who would normally have to undergo an amputation had a better chance of life and were successfully treated. Skin transfers have been reduced in number because the wound healing agent tends to quickly fill the defects created by the wound. It leaves a clean granulation tissue, which subsequently reaches the level of the surrounding, normal, soft tissue. It epithelizes with normal sensitive skin and normal skin color.

Scars are barely visible, defects are minimal and the patients are very happy with the results. Most patients are able to use the wound healing remedy at home without any particular difficulties and the number of visits to the hospital, visits to the hospital for physical therapy or to the doctor's office is reduced.

Most of the wounds treated with the wound healing agent are wounds that would normally be expected to heal more slowly, being a suppurative healing. Actual results show that these wounds heal much faster than wounds that have not been treated in the same way; it is significant that many healed as quickly as pusless wounds.

The wounds heal in a short time with minimal scarring; the healed tissue is free of hypertrophic scars. To date, there have been no keloids. Both laypeople and doctors agree that 15 wounds heal "without scars".

Color and feel develop to normal. The damaged neutral element is promoted in such a way that the injured area becomes innervated and returns to normal feeling.

Wounds in which bones are exposed and infected responded to the treatment in a dramatic manner. Exposed, infected, uncovered, and unprotected bones will usually die. Most doctors 25 agree that every attempt should be made to cover these exposed bones, even at risk of infection. Countless operations have been devised to achieve this. These operations include skin transfers, wound 30 flap closures, relaxation cuts with tissue displacement across exposed areas, muscle stoppages and muscle transfers, as well as abdominal, cross-arm and cross-leg flaps. Neither of these techniques had to be used if there was an open bone in a wound using the wound healing agent. The wound healing agent has promoted the build-up of the granulation tissue to fill the wound and cover the bone, even until the defect has been completely filled and completely covered by skin. No patient who has been treated with this wound healing agent, with or without the use of antibiotics, has developed osteomyelitis. These data should be compared to the frequent occurrence of osteomyelitis after treatment for open fractures 4s in the usual way and using antibiotics, where osteomyelitis occurs in three to six percent of cases.

Limited experience has shown that the wound healing agent applied to fresh first and second degree burns brought immediate pain relief and quick healing of the injured areas. If blisters were present, they either dissolved completely or were protected so that the healing process under them progressed faster than usual. Therefore, the wound healing agent has been used successfully to bring about rapid healing, which is usually a problem associated with blisters and the risk of infection (such as fracture blisters or crushing). In patients with third-degree burns, including deep ones, treatment with the wound healing agent resulted in a rapid transformation of the damaged tissue into clean granulation tissue suitable for skin transfer, usually in a period of 3 to 4 days.

One patient (not an adolescent) had acne on his back and this condition healed quickly after treatment with the wound healing agent. The product has had tremendous results in patients who had suture abscesses (very similar to acne) and were treated with them after surgery. They are usually within one to one

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completely healed two days and there is good reason to believe that the similar effect is achieved in adolescents with acne.

As the cost of medical treatment and hospitalization is increasing, the wound healing remedy is not only that has healing results that have never been shown before, but is used on a variety of wounds even at home by the patient with a minimum of medical supervision can, of particular cost-reducing importance. Its components are readily available and inexpensive. The limitations of its use are minimal, and the benefits of its use far outweigh the few disadvantages.

In the following application examples, the wound healing agent was used in the composition described on page 29, in which it is designated with the US trademark “Sugardyne”, unless the contrary was expressly stated.

In typical dressing technique with this medication, any previously used dressing material is removed, the wound is cleaned with soap and water and then with hydrogen peroxide, and Sugardyne is applied directly to the wound so that it completely covers or fills the wound. Optionally, Sugardyne is applied to a 10.16 x 10.16 cm gauze pad and the resulting dressing is placed face down on the wound. The bandages are changed two or three times a day, the number of dressing changes and the Sugardyne application depends on the type and severity of the wound. In the case of severe wounds, it should be changed more often. The frequency results from clinical assessments and experience. These techniques have been used in the following medical histories unless otherwise stated.

I. AW is a 22 year old male who has been treated for a neuroma that has affected the left big toe, from which the toenail was later removed to remove the neuroma. The nail bed was first treated with iodoform. This was followed by treatment with medicine (Sugardyne ™) without the use of antibiotics in order to obtain a clean-healing nail bed. The Sugardyne ™ dressings were then changed twice a day for three days. Due to the medicine, AW was able to go back to work three days after the operation without pain.

Comment: This case showed the ease of use of the medicine and the absence of pain during outpatient treatment. It also demonstrated the patient's ability to quickly return to work during the healing process.

II. A 70-year-old, white woman (RA) was treated for a follow-up infection after a foot bone fracture. The patient had a weeping wound in the middle view of her leg in the area where the operation had taken place. Given an open fracture, she had been treated with antibiotics for a long time. She was placed on daily Sugardyne ™ dressings with dressing changes twice daily and Keflex * (500 mg) every six hours (after the wound was cleaned with hydrogen peroxide). The wound was almost completely healed after 7 days (with no signs of infection). Her treatment was painless.

* "Keflex" is cephalexin monohydrate, a semi-synthetic oral antibiotic of the cephalosporin type and is sold by Ely Lilly.

Comment: With the use of Sugardyne ™ the treatment was painless. The healing result was quick and the treatment was easy.

s III. A 12-year-old white girl (BB) was treated with Sugardyne ™ against burns after hip surgery. Pain-free bandages were used twice a day for three days, after which time the injured skin was healed without the use of antibiotics and without leaving a scar.

IV. A 90-year-old white man (JD) was treated for multiple fractures on the left foot. He was treated for a bloodless reduction at around 15 and was well three weeks later. After his plaster was removed, he had a weak leg and a foot edema. After that, terrible Edema (secondary) developed immobile and added to his age. And three days after the bandage removal, he had erythema and a watery, infected area that had affected a large part of his foot, ankles, and the secondary leg, which had itched self-induced. The tissue was cleaned with Betadin solution and then treated with Su-25 gardyne ™ over the wounds. Before using Sugardyne ™ dressings (twice a day), the affected tissue was washed with hydrogen peroxide. Although he was told to take Keflex (500 mg) every 6 hours, he later admitted that he hadn't taken antibiotic 30. A day after his initial treatment with the drug, much of the erythema and superficial infection was cleared. Three days later, the substance of the infection was healed, and 6 days later it was almost completely healed. The healing proceeded without leaving any scars.

Comment: The case shows the effectiveness of the drug on the elderly patient with Edema and Erysipelas without antibiotic support.

40 V. A 23-year-old white man (NE) received a severe gunshot wound (0.357 caliber magnum) in his left hand on September 26, 1978, with loss of bone and soft tissue and from distal to the distal half of the 3rd metacarpal and proximal to the proximal half, phalanx of the long finger, including the MP joint. He was first treated with iodoform packs on the open wound and later he was treated with whirlpools, hydrogen peroxide and dressing change with Sugardyne ™. Then the wound underwent another revision, so that his long finger was amputated. He was discharged from the hospital 8 days after the original injury. The wounds on the palmar and dorsal surfaces of the hand were almost completely closed and half a week after the injury with no signs of infection. Four weeks after the injury, he had regained the full functionality of his remaining fingers and was able to form a good fist.

Comment: This case shows the effective use of the drug in a severe gunshot wound comprising 60 hands with minimal scars remaining later and healing quickly, with a quick return to work and a fully functional hand.

VI. A 6-year-old colored boy (HF) had apparently fallen from 65 on his bike and injured his left knee three days before he came to an emergency room. He had a temperature above 39 C and had received penicillin. But after the first investigation was over

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an infected skin abrasion is noticed in and around the surface of the left knee. The patient was treated with Sugardyne ™ in the emergency room and continued with penicillin. A day later he had clean and healing wounds with a clear reduction in the size of the wound. The wound was almost completely healed (with no signs of infection and minimal scarring) within 6 days afterwards.

Comment: This patient demonstrates the rapid healing of severe wounds with the use of antibiotics that was previously ineffective. He was treated without pain; he could be treated without staying in the hospital.

VII. A 28 year old colored woman (BMB) was treated with Sugardyne ™ for an infected burn on the back of her hand. The dressing was changed twice a day. The healing was accomplished in less than a week without scars.

VIII. A 36-year-old colored man (DC) has suffered a deep tear on his right finger since a machine block fell on his hand. The stitched wound was treated immediately. This was done by changing the association with Sugardyne ™ every day. The substance of the healing effect was complete after 9 days. The full motion was recovered in 16 days without scarring.

IX. A 49-year-old white woman (IN) was involved in a car accident in which she received a large hematoma (blood build-up) on her left calf. This was watered in the emergency room and treated with iodoform. After that, daily dressing changes with Sugardyne ™ caused a non-scarred, healed wound within two weeks.

X. A 34-year-old white man (LP) was treated for an ulcer and had many small abscesses below the patella stump. With a variety of medical, local creams, ointments, envelopes, antibiotics and steroids for about a year, all unsuccessful. On examination, the patient showed a very large ulcer with small abscesses that was 3 inches by 3 inches below the knee-stump amputation on the surface. The patient seemed to have both fungal and bacterial contaminants. It was first treated with Sugardyne ™ without the simultaneous use of antibiotics on October 31, 1978, and two weeks later the distal stump was% occluded and had minimal amounts of weeping. The Sugardyne ™ dressings were applied three times a day after cleaning the wound (each time) with water, soap and hydrogen peroxide. The wound was completely healed after one month, although the patient continued to work during treatment.

Comment: This severe ulcer-like wound did not respond to a variety of acceptable treatments, but immediately and without hospitalization to Sugardyne ™ without interrupting the work program. The patient had no discomfort while on the drug; he found it easy to use and apply.

XI. A 5-year-old white boy was injured on his right foot who got caught in a saw machine. He developed necrosis on the side of his foot and severe bruises that caused enormous swelling and blood loss.

He later suffered a fascia incision on the foot and was treated with whirlpools and Sugardyne ™ after his wound had been treated with iodoform for two days. After the iodoform was removed, wound 5 was bloodless. The patient was making great strides and the wound had healed almost three weeks later. After 27 days the patient was completely healed and had minimal scarring, medially and laterally. He had completely filled the medial deficiency and had restored the lateral area, which was previously necrotic. The feeling was normal again, the color, minimal scarring and the total amount of movement and function.

Comment: The expected healing time was significantly rice-reduced and did not require any skin grafts. The patient had no symptoms during treatment with Sugardyne ™.

XII. A 16-year-old white man received a fingertip 20 zen amputation in December 1978. First he was treated with iodoform dressings. The amputation was performed on the second day, the iodoform dressing was removed and the wound was bandaged with Sugardyne ™. The bandages were changed three times a day. On the fourth day, the 25 patient had a clean, healing wound with good granulation tissue in the wound. On the eighth day, the patient had made good progress in healing with narrow peaks in the center of the wound; treatment with Sugardyne ™ dressings, which were changed three times a day, continued, with the wound being cleaned in between with hydrogen peroxide. The wound was completely healed almost 6 days later and in January 1979 it was completely healed. The patient had normal feelings and normal colors with a very slight defect in the fingertips in the sense of a total length.

Comment: Treatment with Sugardyne ™ resulted in restoration of fingertip length, prevented the need for skin grafting, avoided antibiotics 40 and left a quickly healed wound. Furthermore, the treatment costs were significantly lower than if other drugs had been used.

45 XIII. A 7-year-old white boy (DP) was given the following treatment after getting a bruise in a motorcycle accident (the fingertip of his right index finger). He was treated for 10 to 12 days and had a severe infection in his finger, including the end. He was treated with Sugardyne ™, in which the dressings were changed three to four times a day, and the finger was cleaned with hydrogen peroxide. Almost complete healing was achieved a week later; after 13 days, 55 absolute healing without scarring was achieved.

XIV. A 61-year-old colored man (GK) was treated for an injury to his left hand. It contained bruises and deep lacerations (including tendons) on the 60 index fingers, the long finger and the ring finger. He was immediately treated with iodoform, first, then with a whirlpool and finally with Sugardyne ™. The dressings were changed twice a day and with hydrogen peroxide. Almost complete healing took place with a minimum of 65 scarring. A full range of motion was restored within four weeks. The full healing of the long and ring finger was accomplished in less than two weeks.

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XV. A 5-year-old white boy obviously fell and suffered from many abrasions on the right hand, the right side of his face and forehead. A day later, his temperature was elevated and his wounds were covered with pus. After cleaning his wounds, they were bandaged with Sugardyne ™. His mother changed dressings twice a day and the patient had to use erythromycin every 6 hours (250 mg). Two days later, the patient's wounds were almost completely healed without any signs of infection or scars.

Comment: The healing took place quickly. The patient did not complain of pain throughout the treatment.

XVI. A 41-year-old white man (RK) suffered a deep skin abrasion in his right shin, approximately in the middle down to the bone. His wound was infected with Mississippi River water, including mud. Within two days it was still dirty and infected. Treatment was initiated on the second day with Sugardyne ™ dressings, changed twice daily, and cleaned with hydrogen peroxide. The wound healed quickly without further infections and covered with skin with a slightly brownish losing color, but with full feeling and full hair coverage.

Comment: The case demonstrates the effectiveness of Sugardyne ™ in wounds with open, uncovered, infected bones and soft tissue and without concomitant use of antibiotics.

XVII. A 41-year-old white man, surgeon (RK), who had first and second degree burns on his left hand, from the explosion of a matchbox received aspects on the volar and dorsal that included the base of the thumb, the palm of the hand, the dorsum hand and all four fingers. Immediate treatment with Sugardyne ™ and a dry bandage had taken place. The patient was later able to remove the dressings within four hours with a complete decrease in first and second degree burns, including all small blisters. The pain disappeared immediately and the patient was able to go back to work immediately, including complete hand use after four hours. He was able to operate the next morning with no burns or pain.

Comment: The case shows the double effect in terms of quick healing and in terms of eliminating pain of the patient to be treated. It demonstrates the effectiveness of Sugardyne ™ in giving the patient the opportunity to return to work immediately.

XVIII. A 63-year-old white man (AK) received a gunshot wound in his right ankle in 1965, with the following fusion of the ankle. The patient had a constantly purulent ankle and this irrigation resulted in a Staphylococcus aureus culture.

Because of the irrigation, he had to take antibiotics all the time, which usually worked after a period of swelling and wetting. The patient was treated with Sugardyne ™ (since June 1978) and already had a decrease in inflammation. If the inflammation occurred, he had already healed quickly using Sugardyne ™. He usually begins treatment as soon as he notices the erythematous areas; healing usually occurs within a day or two.

Comment: This patient shows the effectiveness of Sugardyne ™ in Chronic Osteomyelitis and also shows that

Effectiveness of this drug when compared to the normal outcome of antibiotics on the patient.

XIX. A 22-year-old white woman (EH) was treated in an emergency operating room after an automobile accident on August 5, 1978, after she had received many skin abrasions and lacerations and a deep laceration to the medial of her left knee. After cleaning, the deep tear wound was closed over a drain and the patient was connected to Sugardyne ™ for two days. Her wound healed two days later with no signs of infection. By the sixth day, her wound was almost completely healed. Her wound healed afterwards with minimal signs of scarring, in all skin abrasions and lacerations and she had no keloid formation. The dressings were changed twice a day during treatment.

Comment: The patient could be treated without antibiotics and had uneventful, uncompromised, comfortable recovery through the use of Sugardy

XX. A 13-year-old white boy suffered a tear and fracture on his left elbow a week before he was treated in the emergency room. He had an erythematous area in the lateral area of the elbow and was feverish. He obviously had an early infectious laceration on the left elbow. Treatment with cleansing betadine included cleaning and bonding with Sugardyne ™. The patient was placed on Keflex (250 mg) every 6 hours. In the following days the patient's symptomatology disappeared and a great deal of the erythema decreased. The early infection completely healed within two days.

Comment: This case shows the rapid healing of infected lacerations and open fractures through the use of Sugardyne ™, used in combination with antibiotics.

XXI. A 35-year-old colored man (CW) had been hospitalized after his left arm was stabbed through and through at the level of the bone. The patient's first treatment included an intravenous antibiotic and a wound-wrapped solution to prevent infection. He was then treated with Sugardyne ™ in the hospital and also on an outpatient basis until the wound was clean enough to close it with sutura. That was done three weeks later and it continued in his uneventful further healing.

Comment: The possibility of infection in this serious wound was alleviated by the use of Sugardyne ™ and also by antibiotics. The patient healed with minimal scarring and no infection. Many of these treatments are carried out on an outpatient basis.

XXII. A 54-year-old white lady (KW) was treated for a massive infection in her left leg. The infection ended in a severe abscess that had to be amputated on June 5, 1978. Due to the slow resolution of her infection, she was treated with both Sugardyne ™ and antibiotics, which led to complete cleaning and granulation of the distal stump. Afterwards, she underwent a revision of this amputation and was discharged from the hospital after 6 days. By the end of the third week, the stump was completely healed, with not a single scar.

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Afterwards she received an under-knee prosthesis and has had minimal problems since then. The dressings were changed three times a day with Sugardyne ™. Antibiotics were given every 6 hours.

Comment: A difficult problem was carefully handled in the middle ages with the use of Sugardyne ™, with fast healing time, so the procedure could help the patient to be discharged from the hospital sooner.

Treatment has been greatly improved with this drug and the possibility of dying from infection has been avoided with the simultaneous use of Sugardyne ™ and antibiotics. No development has been made in the treatment with Sugardyne ™.

XXIII. A 54-year-old white woman (MW) developed a stab abscess after surgery on her wrist. She was treated with Sugardyne ™ and Keflex (250 mg) every six hours. After that, she healed well without leaving any scars.

Comment: This case shows the use of Sugardyne ™ for a common problem after surgery.

XXIV. A 35-year-old colored man (JK) was injured on May 28, 1978 while riding his motorcycle. He suffered a lot of skin abrasion and both the upper extremities, including the shoulders, hands and bones of the hand (especially on the right side). The wounds were treated in the emergency room. After a day they were covered with large amounts of pus and appeared to be burned. The wounds were cleaned with betadine solution and bandaged with Sugardyne ™. The wound was clean within two days, fresh granulation tissue had formed and no longer a sign of infection. The wounds were almost completely filled within a week and most of them were completely covered with normal black skin. Three days later the wounds were almost healed and brown skin covered the previously injured tissue. The tissue was normal and with feeling.

Comment: The patient was able to treat his wounds at home without infection and with a good end result, although there could have been a very serious body infection. His wounds healed with Sugardyne ™ without scarring and pigment loss. His treatment was painless.

XXV. A 26-year-old white man (JMC) had received a dirty tear in the middle part of the volar, his right forearm, which was later infected (although he was treated with antibiotics), about 5 days after the first treatment. The first treatment included removing some sutures and treating the wound with iodoform. Two days later, the wound, which was ulcerated but not bleeding, was treated with Sugardyne ™. It then healed in about 7 days without further infection and with minimal scarring. The patient bandaged his wound daily, used hydrogen peroxide to clean the wound, and Sugardyne ™ and a dry bandage.

Comment: The patient was able to continue working even though he had an infected wound. It was quickly curable in this form and without secondary pain.

XXVI. A 58-year-old white man (WMG) had undergone a partial amputation of his right foot 10 years earlier because he had diabetic gangrene. He had some

Had foot ulcers that forced him to go to the hospital every month for two to three years. During this time, the patient had become dependent on pain tablets. He was treated with various medications that contained both systemic and oral antibiotics and also required dressings to treat the ulcers.

In general, when the ulcers became infected, the diabetes grew over his head, forcing him to go to the hospital. The patient has been using Sugardyne ™ for his daily dressing change for a year now. He washes his wound with soap, water and hydrogen peroxide before changing the dressing. During this time, he no longer had to go to the hospital, take antibiotics, as he had in the past. His diabetes has stabilized and he is completely pain free, which frees him from taking the narcotics.

Comment: Although the patient's diabetes and chronic ulcers have not yet healed, Sugardyne ™ has stabilized his health because he no longer needs to go to the hospital and he has his diabetes under control . He is released from his addiction to narcotics.

XXVII. A 29-year-old white man (CMD) was injured three or four days before being seen. A large board had fallen on his ankle, teaching him a soft tissue injury and an ankle sprain. The patient later developed an abscess that was treated with Sugardyne ™. The first treatment included jo-doform dressings, which were removed after a day and a half and at the time some pus had formed but no bleeding. The wound was almost completely healed within four days of the first treatment.

Comment: The patient could be treated on an outpatient basis although he had a significant ankle injury. This did not include taking antibiotics. The patient was able to use Sugardyne ™ with ease and had no pain.

XXVIII. A ten-year-old black boy received a deep tear and contusion to the distal part of the right index finger, including villi fracture, when a stone fell on him. The patient's first treatment was with Sugardyne ™. The patient received a dressing change and wound examination in the emergency room. The wound was completely healed within four days with no scarring.

Comment: The case shows the rapid, uneventful healing with little hospitalization, without the use of antibiotics, simple use and minimal pain for the patient.

XXIX. _ A 30-year-old white woman (SH) was treated in an emergency operating room after receiving an open fracture of the middle phalanx, the left long finger, from an ax injury. She was initially treated with a bloody reduction, internal fixation and suture of the torn tendon, with antibiotics and Sugardyne ™ dressing change after the wound was sewn. It healed quickly without infection. Subsequently, she had minimal scars on her finger without a keloid formation. The fracture healed completely three months after the accident.

Comment: A serious accident that almost resulted in an amputated finger could be treated without hospitalization; it healed with Sugardyne ™ Be5

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action without scarring. The patient was able to treat herself at home.

XXX. A 7-year-old white boy (JL) almost suffered an amputation (through an ax) from his index finger and middle finger, his left hand. The patient received a first cleaning treatment and stabilization of the fingers with a K-splint. His lichen had healed and the skin had closed, changing the wounds with Sugardyne ™. The patient underwent an uneventful recovery process, with the wounds healing almost completely within a week. There was no infection, so the fracture healed without side effects. The patient had no visible scars.

Comment: The case shows rapid healing of contaminated, injured tissue, including bones, without infection, using Sugardyne ™ as the main wound dressing.

XXXI. A 59-year-old butcher (HB) who amputated a third distal to his right middle finger (distal phalanx) while working as a butcher received initial treatment in the emergency room. This treatment included stopping blood from the soft tissue and bone end at the end of the amputated fingertip. Treatment was with iodoform mull and after a day with Sugardyne ™. The dressings were changed twice a day after being cleaned with hydrogen peroxide. The patient was completely healed in four weeks, with the restoration of approximately three quarters of the lost tissue, without skin transfer.

He has feeling again and good pulp on his fingertips.

Comment: This case shows tissue restoration after fingertip amputation using Sugardyne ™ for daily dressing changes. No antibiotics were used, although the bone was open and exposed. The treatment was painless.

XXXII. A 10-year-old boy (JW) was treated to a two-inch splinter embedded in the sole of the foot. After cleaning the foot, the splinter was removed under local anesthesia. Sugardyne ™ was used to treat the wound and oral antibiotics were given to the patient. The foot healed completely in two days, without infection and twice a day changing the dressing.

Comment: This case shows the effectiveness of Sugardyne ™ in contaminated tissue, in terms of preventing infection and quick healing. The oral anti-biotic was Keflex, administered every 6 hours.

XXXIII. A 16-year-old white boy was injured 19 days before being viewed; the fourth and fifth fingers of his left hand were sprayed with liquid propane; the result was frost damage (full density - 3rd degree), especially the middle part of his fifth finger. Both fingers were initially blistered, although they had already been treated with betadine (P-J) solution, both fingers had become infected.

Nearly 2 / s fifth finger dorsum was infected, both PIP and DIP joints. On January 4, 1979, 19 days after the injury, the patient started using Sugardyne ™ two to three times a day. Within four days the wound was clean with no signs of infection. On the fifth day, a skin margin of 1/2 inch appeared at the edge of the wound; 11 days later, the wound was more than 50 percent covered with skin. Two weeks later the wound was completely healed, without scars. The patient was able to move all of his finger joints within a full range of motion.

Comment: This case shows the effectiveness of Sugardyne ™ in difficult burns, overlapping skin folds. Rapid healing, although previously it was only treated with P-I solution, which was ineffective for 3 weeks.

XXXIV. A 15-year-old white boy (K) suffered from an open fracture of his right tibia, with protruding bones protruding from the skin while riding a bicycle on July 24, 1978. Flushing and debridement were Room made; they were stabilized with K-wires * and plaster. The wound was closed over a drain and was later treated with Sugardyne ™ 3 times a day. The wound was completely healed within 16 days without infection. No antibiotic was given to the patient for seven days. The recovery was uneventful without osteomyelitis.

Comment: This case shows an open fracture that was successfully treated with Sugardyne ™.

XXXV. A 15-year-old white boy suffered from a contaminated fracture of his right tibia. He was treated in an operating room with irrigation and debridement of the open wound, with the closure loosely over a drain. They received stabilization of the fracture with a K-splint and impression. Other treatments, including removal of the drain and antibiotics. On the third day, Sugardyne ™ was given to him and the wound healed without infection. The bone healed as usual.

Comment: The case shows the effectiveness of Sugardyne ™ in open fractures. The wound healed quickly and without infection of the fracture and without scars.

XXXVI. A 13-year-old, colored boy was treated for a large abscess in his left knee. He had had a knee injury for three weeks caused by an accident. The injured area developed into a 3-inch x 4-inch abscess. The abscess was treated under local anesthesia on February 27, 1979. Large amounts of pus were secreted from the abscess, which was treated with iodoform and then with Sugardyne ™. The patient spent a day at the weekend in the hospital to expand the treatment, the almost complete dissolution of the abscess was achieved in four days.

Almost complete healing was achieved in six days. The patient received complete tissue renewal without the abscess recurring.

Comment: This case shows how helpful Sugardyne ™ is to pull pus out of the wounds (or abscesses). It also shows the use of this drug in the full, rapid healing of the wound.

The invention and its advantages can be understood immediately from the previous description. Various changes can be made in manufacture and in combination without departing from the actual idea of the invention and without giving up the other advantages.

* K-Wires, K-Wires or Kirschner Wires are stainless steel wires to stabilize fractures and to join them together by exerting tension. They are distributed by the V. Müller Division of American Hospital Supply Company.

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Claims (12)

653 892 2nd PATENT CLAIMS 1. wound healing agent, characterized in that it is homogeneous and contains the following components: a) 10 to 80 parts by weight of an antibacterial tissue nutrient, b) 1 part by weight of active fungicidal / antibacterial agent which is physically, chemically and pharmacologically compatible with a), and c) a sufficient amount of carrier substance which gives the mixture a consistency in which the agent is simply applied to a sponge or gauze and in which it remains at the place of use if it is applied directly to the tissue of an open wound or a burn and where this carrier substance is physically, chemically and pharmacologically compatible with both a) and b) and its amount is at most one third the weight of the wound healing agent. 2. Wound healing agent according to claim 1, characterized in that component a) consists of sugar, glucose, dextrose, fructose, honey and / or molasses. 3. wound healing agent according to claim 1, characterized in that the component a) is granulated sugar. 4. wound healing agent according to claim 1, characterized in that the component b) is polyvinylpyrrolidone-iodine complex. 5. wound healing agent according to claim 4, characterized in that component a) is 25 to 55 parts by weight of granulated sugar. 6. Long storable wound healing agent according to claim 1, characterized in that it contains, as component a) granulated sugar and as component c) a stabilizing carrier substance which prevents segregation of the wound healing agent. 7. Wound healing agent according to claim 6, characterized in that it contains 20 parts by weight of component a), 5 parts by weight of an ointment with the following composition: Polyvinylpyrrolidone iodine powder 45.5 g Polyethylene glycol (PEG) 400 272.4 g PEG 4000 113.5g Water qs 453.6 g PEG 400: molecular weight between 380 and 420 PEG 4000: molecular weight between 3,000 and 3,700 and 2 parts by weight of a solution with a substance with the following composition: PVP-J powder 125 g Sodium phosphate (tribasic) 7.5 g Octylphenoxy polyethoxyethanol 4 g Water contains qs 1,000 g. 8. wound healing agent according to claim 1, characterized in that the component c) is water-soluble. 9. wound healing agent according to claim 1, characterized in that the component b) is water-soluble. 10. Wound healing agent according to claim 1, characterized in that the component a) is sugar and the components b) and c) are water-soluble. 11. Wound healing agent according to claim 10, characterized in that it contains between 25 and 55 parts by weight of component a), while component b) is polyvinyl-pyrrolidone-iodine complex. 12. Wound healing agent according to claim 1, characterized in that it is essentially non-allergenic. Bandages are usually used to cover open wounds and burns. There is always an urgent need for a non- allergenic, antibacterial and fungicidal agent, which has high-quality healing properties and yet allows the covering of the wounds or burns without causing the growth of tissue healing in gauze or similar dressings. More than two years ago, even before the invention of the substance, only sugar was used on the wounds, either as a single component or in conjunction with povidone iodine (Betadin0 solution). During this time the sugar (if the wound was deep) was placed directly into the wound. A 4-inch (10.16 cm) by 4-inch sponge or other dressing material was soaked in a betadine solution and used to bandage the wound. The dressing was changed every 6 to 8 hours. Less deep wounds were bandaged with sponges dipped in betadine solution, which were then covered with about 0.25 inches (0.635 centimeters) of sugar and placed face down on the wound (sugar in direct contact with the wound). Betadin8 (Betadine) is a product of the Purdue Frederick Company with the following composition: PVP-J powder 125 g Sodium phosphate (tribasic) 7.5 g Triton X-l 14 4 g Water qs 1,000 g Triton X is octylphenoxy polyethoxyethanol. In Germany, Betadine is sold under the trademark Betaisodona. Betadine ointment is also sold by the Purdue Frederick Company and has the following composition: PVP-J powder 45.5 g Polyethylene glycol (PEG) 400 272.4 g PEG 4000 113.5g Water qs 453.6 g PEG 400: molecular weight between 380 and 420 PEG 4000: molecular weight between 3,000 and 3,700 In this way, although there were difficulties in handling and lack of control and uniformity of the cases, the wound healing time was significantly reduced. In more than 300 cases, the use of povidone iodine solution in combination with sugar has been shown to be a safe, reliable, and rapid method of healing a variety of wounds. This includes both clean and infected wounds, as well as fresh and old wounds. Their diversity ranged from simple skin abrasions and flesh wounds to severe, soft tissue injuries (tissue trauma), including burns, bruises, shot and shot wounds; Bedsores, diabetes and circulation ulcers, as well as open fractures. In the case of severe, soft tissue injuries (tissue trauma such as shot wounds and second or third degree burns), debridement was just as necessary as routine wound care. Afterwards, by repeated dressing changes with sugar and povidone-iodine solution, it was found that regardless of the absence of system antibiotics, a quickly forming, granulating wound was produced without crusting and superficial infection. Surprisingly, this treatment produced a large amount of granulating tissue that was sufficient to fill in large soft tissue injuries, the subsequent side effects that only occurred secondarily to the original wound. The newly overgrown tissue granulation became covered with skin naturally. As a result, a great reduction in healing time was achieved and the necessary tissue transfer was restricted. In general, an s 10th 15 20th 25th 30th 35 40 45 50 55 60 65 3rd 653 892 Tissue regeneration is achieved sooner than wound shrinkage. In many cases the healed wound was soft and elastic, with good sensitivity. There is good evidence to suggest that sugar products such as honey and molasses have been used in wounds to be treated, including burns, in the past. The evidence suggests that Native Americans to the Inca Empire had experience using some medical compounds that were promising in treating wounds and burns. These included: herbs, root extracts, leaf extracts and various maple molasses, millet, molasses, honey and finally sugar (like sugar cane). In ancient Egypt, the use of sugar products was included to preserve food and treat wounds. Povidone-iodine (polyvinylpyrrolidone-iodine complex) is locally anti-infectious ("The Merck Index", 9th edition, pages 996 and 997, entry 7499, Merck & Co., Inc., 1976) and on the market in a large number of forms commercially available, e.g. Betasin antiseptic gauze pillow, solution, swab solution swab, spray cans, surgical hand disinfectant, vaginal irrigation, vaginal gel, skin cleanser, ointment, microbicidal bath, perineal bath, strudel concentrate (Physicians Desk Reference (PDR, 31. Edition, pages 1263 to 1265, 1977).