CN101623248B - Medicated toothpaste - Google Patents
Medicated toothpaste Download PDFInfo
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- CN101623248B CN101623248B CN 200910302560 CN200910302560A CN101623248B CN 101623248 B CN101623248 B CN 101623248B CN 200910302560 CN200910302560 CN 200910302560 CN 200910302560 A CN200910302560 A CN 200910302560A CN 101623248 B CN101623248 B CN 101623248B
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Abstract
The invention provides medicated toothpaste for effectively preventing and treating stomatosis, wherein every 100kg of finished paste contains Zhuang medicine blumea aromatica DC extract which is extracted from 1-150kg of Zhuang medicine blumea aromatica DC material. The medicated toothpaste not only has highly-effective hemostatic and anti-inflammatory functions to the human oral cavity, but also has the advantages of easy preparation, low cost, safety and reliability.
Description
Technical field
The present invention relates to the oral cleaning nursing article technical field, especially a kind of toothpaste that includes ancillary drug.
Background technology
Toothpaste is indispensable oral cavity cleaning hygienic article in people's daily life, and its basic function is cleaning teeth, and fresh breath reaches the purpose that keeps oral cavity cleaning.In recent years, because the consumer healthcare realizes continuous enhancing, toothpaste has been proposed more requirement, some auxiliary prevention oral diseases have also been increased except cleaning the teeth, there is the function of nursing health effect in the oral cavity, and therefore, the product that has various functional types both at home and abroad in the toothpaste becomes the market mainstream, again because the Chinese medicinal plant active component has the incomparable advantages of Western medicine such as natural, safe, so become the emphasis of current development on the market with the functional type toothpaste of active ingredient of Chinese herbs.In recent years, along with the development of modernization of Chinese medicine technology, the method for active ingredient of Chinese herbs research and utilization has also been obtained fine development, this assists the prevention oral disease that good technical support is provided for toothpaste utilizes active ingredient of Chinese herbs.
In recent years, also have in the prior art and adopt various active ingredient of Chinese herbs as the toothpaste ancillary drug, in these medicated toothpaste, some toothpaste has the plurality of Chinese composition, the producing process complexity; Though some toothpaste producing process is simple, effect is had nothing in common with each other.So far as yet not relevant for utilizing strong medicine mountain breeze as the research of auxiliary Chinese medicine ingredients or the report of application in the toothpaste.The applicant has carried out long-term a large amount of research and application test to this, make strong medicine mountain breeze extract obtain affirmation as safety, treatment effectiveness and the certainty of raw material of toothpaste.
Summary of the invention
The problem to be solved in the present invention provides a kind of medicated toothpaste with obvious hemostasis, antiinflammation.
For solving the above problems, add the Chinese medicine extract have with Radix Cirsii Japonici in the toothpaste of the present invention as the effective ingredient that plays the auxiliary treatment effect, make toothpaste have obvious hemostasis, antiinflammation, this medicated toothpaste includes the strong medicine mountain breeze extract that extracts from 0.1 kilogram～15 kilograms former medicines of strong medicine mountain breeze in the mastic of this toothpaste of every double centner; Except that described strong medicine mountain breeze extract, generally also include foaming agent of the prior art in the above-mentioned mastic, abrasive, wetting agent, thickening agent and flavoring agent etc. are made the base stock of toothpaste and the water of surplus.
Described foaming agent is nontoxic alkane anion surfactant such as sodium lauryl sulphate, also can use sodium lauroyl sarcosine, potassium salt, it can make product, and zest is low as mild as a dove, also can use non-ionic surface active agent such as lauryl alcohol diethanolamine, tween, dodecyl amine oxide, polyoxyethylene and polyoxypropylene block copolymers etc.Described abrasive is calcite in powder, silicon dioxide, calcium hydrogen phosphate, anhydrous Metaphosphoric acid sodium salt, resin etc.; Described wetting agent is that the combination in any of any or they in the middle of the sorbitol, propylene glycol, glycerol, xylitol constitutes; Described thickening agent is that any or the combination in any in them in the middle of the sodium carboxymethyl cellulose, carrageenan, guar gum constitutes; Described flavoring agent generally is made of various sweeting agents and spice.In addition, can also add the auxiliary agent that adopts usually as in the antiseptic of sodium benzoate and other existing toothpaste in the mastic.Above-mentioned foaming agent, abrasive, wetting agent, the use amount of thickening agent, flavoring agent and antiseptic etc. gets final product by use amount of the prior art.
Strong medicine mountain breeze (Blumeaaromatica DC.) is the dry herb of Compositae Herba Blumeae Balsamiferae platymiscium fragrance virtue Herba Blumeae Balsamiferae, plant name fragrance virtue Herba Blumeae Balsamiferae, nature and flavor suffering, little hardship, temperature can promoting blood circulation and detumescence, among the peoplely in the Zhuang area are used for treating diseases such as rheumatic arthralgia, traumatic hemorrhage.Its detumescence effect of invigorating blood circulation is just meeting strong doctor's regulating QI, detoxifcation, the Therapeutic Principle of tonify deficiency.Its wide material sources are convenient to pluck.Strong medicine mountain breeze extract wherein can adopt existing Chinese medicine to make the process preparation of extracting solution, extractum and extraction powder, also can adopt the strong medicine mountain breeze of market supply to extract manufactured goods, extract powder etc. as strong medicine mountain breeze extracting solution, strong medicine mountain breeze extractum, strong medicine mountain breeze.When the strong medicine mountain breeze that adopt to adopt market supply extracts manufactured goods, extract manufactured goods according to strong medicine mountain breeze and be equivalent to former dose and convert out the addition that strong medicine mountain breeze extracts manufactured goods according to the former dose of strong medicine mountain breeze required in the above-mentioned toothpaste finished product and get final product.
The present invention is through experiment confirm, and the above-mentioned toothpaste that contains strong medicine mountain breeze extract has significant hemostasis, antiinflammatory effect, can be used for preparing oral cavity composition.
Adopt the anastalsis experimental technique of the dirty local woanded surface bleeding due to trauma of Hepar Mus.Get 40 of kunming mices, body weight 18～22g, male and female dual-purpose.The blank group adopts the starch group, the blank matrix group of toothpaste (do not contain strong medicine mountain breeze extract, other presses embodiment 1 preparation), and positive controls adopts YUNNAN BAIYAO, toothpaste sample group (pressing embodiment 1 preparation).Behind the pentobarbital sodium anesthetized mice, open abdomen, expose liver, cut off the about 1cm of a block length with shears in liver surface, the tissue of wide about 0.2cm is covered up by the gauze of reagent thing with scribbling, every 15s, observe once, the record bleeding stopping period writes down and carries out statistics t check, the results are shown in Table 1.
Table 1 toothpaste sample is to the haemostatic effect of kunming mice liver local woanded surface bleeding due to trauma (X ± SD)
| Group | The laboratory animal number | Bleeding stopping period (s) |
| The starch group | 10 | 92.6±17.7 △ |
| The blank matrix group of toothpaste | 10 | 95.7±21.3 △ |
| The YUNNAN BAIYAO group | 10 | 24.3±7.6 *● |
| The toothpaste sample group | 10 | 29.0±9.9 *▲ |
Annotate: compare * P＜0.05 with the blank group; Compare ▲ P＞0.05 with positive controls; Compare △ P＜0.05 with positive group; Compare with the blank matrix group of toothpaste, ● P＜0.05;
Experimental result shows that toothpaste sample group and YUNNAN BAIYAO group all have tangible anastalsis to mouse liver local woanded surface bleeding due to trauma.
The antiinflammatory pharmacological experiment of strong medicine mountain breeze extract toothpaste: adopt xylol to cause the antiinflammatory action experimental technique of Mice Auricle acute inflammation swelling.Get 40 of healthy male Kunming kind white mice, body weight 18～22g divides equally 4 groups at random, 10 every group.Blank group (distilled water 0.1ml/ is only), the blank matrix group of toothpaste (do not contain strong medicine mountain breeze extract, other presses embodiment 1 preparation, and 0.1g/ is only), aspirin group (aspirin 0.1g/ is only), toothpaste sample group (press embodiment 1 preparation, 0.1g/ is only).Respectively organize the inside and outside two sides of every animal auris dextra exterior feature during experiment and only evenly smear dimethylbenzene 0.1ml/, cause inflammation, left ear does not add to handle makes self blank.After smearing dimethylbenzene 30min, each is organized the inside and outside two sides of every animal auris dextra exterior feature and evenly smears each group respectively and only tried matter sample 0.1g/.Behind the administration 1h, the dislocation of mice cervical vertebra is put to death, cut two auricles, tried matter sample with normal saline flush away auris dextra exterior feature, dry cotton ball is cleaned, overlapping two auricles, card punch with internal diameter 8mm is got two circle auricles at same position cutter, weigh on FA1004 type electronic analytical balance respectively, it is the swelling value that auris dextra sheet weight deducts left auricle weight, and data are carried out statistics t check.The results are shown in Table 2.
The influence of table 2 toothpaste sample xylol induced mice auricle acute inflammation swelling (meansigma methods X ± SD, n=10)
| Group | Dosage (g/ only) | Auricle edema value (mg) |
| The blank group | 0.1ml/ only | 7.360±2.1078 |
| The blank matrix group of toothpaste | 0.1 | 9.330±2.4258 |
| The aspirin group | 0.1 | 4.050±1.7640 * |
| The toothpaste sample group | 0.1 | 4.950±0.7184 *，*▲ |
Annotate: compare * P＜0.05 with the blank group; Compare * ▲ P＞0.05 with positive controls.
Experimental result shows, toothpaste sample and aspirin group all can make chmice acute inflammation swelling auricle weight significantly alleviate, obviously suppress the swelling of dimethylbenzene induced mice auricle acute inflammation, there were significant differences statistically, shows acute inflammation is had tangible antiinflammatory action.
The specific embodiment
Below in conjunction with embodiment, the present invention will be further described.
The making of 8 routine medicated toothpaste:
One, among the embodiment 1～8, it is raw materials used as following table (unit: kilogram whenever to make the double centner lotion of toothpaste.)
Two, preparation method
1, the preparation of strong medicine mountain breeze extract
Among each embodiment of the following stated, described strong medicine mountain breeze extract is broken 10 orders-30 order of the herb coarse powder with Compositae Herba Blumeae Balsamiferae platymiscium fragrance virtue Herba Blumeae Balsamiferae, with the alcohol heating reflux extraction of 10 times of amounts 3 hours, extracts 3 times, then extracting solution is merged, concentrating under reduced pressure is dried to powder.
2, the preparation of medicated toothpaste mastic
The existing conventional prepared of producing lotion of toothpaste of this employing gets final product, and strong medicine mountain breeze wherein extracts powder and adds in company with the powder in the raw material, and concrete grammar is as follows:
The preparation method of embodiment 1,8: liquid material such as the pure water that input measures in temporary cylinder, sorbitol, xylitol; Powders such as the calcite in powder that input measures in pre-dispersed still, saccharin sodium, carboxycellulose sodium, sodium lauryl sulphate, strong medicine mountain breeze extract, sodium benzoate carry out pre-dispersed, mixing; Open system cream still vacuum pump and suck above-mentioned liquid material; Open scraper then, advance above-mentioned powder, drive agitator and colloid mill, drop into essence after 50 minutes, close colloid mill, agitator, scraper after 10 minutes successively, vacuum breaker stops vacuum pump, makes after the sampling detection is qualified.
The preparation method of embodiment 2,4,7: liquid material such as the pure water that input measures in temporary cylinder, sorbitol; Powders such as the calcium hydrogen phosphate that input measures in pre-dispersed still, silicon dioxide, saccharin sodium, carboxycellulose sodium, sodium lauryl sulphate, strong medicine mountain breeze extract, sodium benzoate carry out pre-dispersed, mixing; Open system cream still vacuum pump and suck above-mentioned liquid material; Open scraper then, advance above-mentioned powder, drive agitator and colloid mill, drop into essence after 50 minutes, close colloid mill, agitator, scraper after 10 minutes successively, vacuum breaker stops vacuum pump, makes after the sampling detection is qualified.
The preparation method of embodiment 3,5,6: liquid material such as the pure water that input measures in temporary cylinder, sorbitol; Powders such as the silicon dioxide that input measures in pre-dispersed still, saccharin sodium, carboxycellulose sodium, sodium lauryl sulphate, strong medicine mountain breeze extract, sodium benzoate carry out pre-dispersed, mixing; Open system cream still vacuum pump and suck above-mentioned liquid material; Open scraper then, advance above-mentioned powder, drive agitator and colloid mill, drop into essence after 50 minutes, close colloid mill, agitator, scraper after 10 minutes successively, vacuum breaker stops vacuum pump, makes after the sampling detection is qualified.
Claims (8)
1. medicated toothpaste, it is characterized in that including in the mastic of every double centner: the strong medicine mountain breeze extract that from 150 kilograms of former medicines of strong medicine mountain breeze, extracts, 2.1 kilograms of sodium lauryl sulphates, 50 kilograms of calcite in powder, 20 kilograms of sorbitol, 1.0 kilograms of sodium carboxymethyl cellulose, 0.25 kilogram of saccharin sodium, smart 1.0 kilograms of Herba Menthae Rotundifoliae, 0.15 kilogram of sodium benzoate, the water of 0.2 kilogram of tetrasodium pyrophosphate and surplus; Described strong medicine mountain breeze extract is that the herb with Compositae Herba Blumeae Balsamiferae platymiscium fragrance virtue Herba Blumeae Balsamiferae is broken into 10 orders-30 purpose coarse powder, extracts 3 hours with the alcohol heating reflux of 10 times of amounts, extracts 3 times, and with the extracting solution merging, concentrating under reduced pressure is dried to powder then.
2. medicated toothpaste, it is characterized in that including in the mastic of every double centner: the strong medicine mountain breeze extract that from 10 kilograms of former medicines of strong medicine mountain breeze, extracts, 2.2 kilograms of sodium lauryl sulphates, 40 kilograms of calcium hydrogen phosphate, 0 kilogram of silica 1,18 kilograms of sorbitol, 0.6 kilogram of guar gum, 0.7 kilogram of sodium carboxymethyl cellulose, 0.3 kilogram of saccharin sodium, 1.2 kilograms of fruit essences, 0.15 kilogram of sodium benzoate, the water of 0.2 kilogram of tetrasodium pyrophosphate and surplus; Described strong medicine mountain breeze extract is that the herb with Compositae Herba Blumeae Balsamiferae platymiscium fragrance virtue Herba Blumeae Balsamiferae is broken into 10 orders-30 purpose coarse powder, extracts 3 hours with the alcohol heating reflux of 10 times of amounts, extracts 3 times, and with the extracting solution merging, concentrating under reduced pressure is dried to powder then.
3. medicated toothpaste is characterized in that including in the mastic of every double centner: the strong medicine mountain breeze extract that extracts from 87 kilograms of former medicines of strong medicine mountain breeze, 2.3 kilograms of sodium lauryl sulphates, 20 kilograms of silicon dioxide, 16 kilograms of sorbitol, 5 kilograms of propylene glycol, 10 kilograms of glycerol, 0.5 kilogram of carrageenan, 1.0 kilograms of sodium carboxymethyl cellulose, 0.3 kilogram of saccharin sodium, 1.0 kilograms in Herba Menthae essence, 0.15 kilogram of sodium benzoate, the water of 0.15 kilogram of tetrasodium pyrophosphate and surplus; Described strong medicine mountain breeze extract is that the herb with Compositae Herba Blumeae Balsamiferae platymiscium fragrance virtue Herba Blumeae Balsamiferae is broken into 10 orders-30 purpose coarse powder, extracts 3 hours with the alcohol heating reflux of 10 times of amounts, extracts 3 times, and with the extracting solution merging, concentrating under reduced pressure is dried to powder then.
4. medicated toothpaste, it is characterized in that including in the mastic of every double centner: the strong medicine mountain breeze extract that from 125 kilograms of former medicines of strong medicine mountain breeze, extracts, 2.2 kilograms of sodium lauryl sulphates, 38 kilograms of calcium hydrogen phosphate, 0 kilogram of silica 1,16 kilograms of sorbitol, 0.6 kilogram of guar gum, 0.7 kilogram of sodium carboxymethyl cellulose, 0.25 kilogram of saccharin sodium, smart 1.2 kilograms of Herba Menthae Rotundifoliae, 0.15 kilogram of sodium benzoate, the water of 0.15 kilogram of tetrasodium pyrophosphate and surplus; Described strong medicine mountain breeze extract is that the herb with Compositae Herba Blumeae Balsamiferae platymiscium fragrance virtue Herba Blumeae Balsamiferae is broken into 10 orders-30 purpose coarse powder, extracts 3 hours with the alcohol heating reflux of 10 times of amounts, extracts 3 times, and with the extracting solution merging, concentrating under reduced pressure is dried to powder then.
5. medicated toothpaste is characterized in that including in the mastic of every double centner: the strong medicine mountain breeze extract that extracts from 32 kilograms of former medicines of strong medicine mountain breeze, 2.2 kilograms of sodium lauryl sulphates, 50 kilograms of calcium hydrogen phosphate, 18 kilograms of sorbitol, 5 kilograms of propylene glycol, 9 kilograms of glycerol, 0.5 kilogram of carrageenan, 0.7 kilogram of sodium carboxymethyl cellulose, 0.2 kilogram of saccharin sodium, 1.1 kilograms in Herba Menthae essence, 0.15 kilogram of sodium benzoate, the water of 0.2 kilogram of tetrasodium pyrophosphate and surplus; Described strong medicine mountain breeze extract is that the herb with Compositae Herba Blumeae Balsamiferae platymiscium fragrance virtue Herba Blumeae Balsamiferae is broken into 10 orders-30 purpose coarse powder, extracts 3 hours with the alcohol heating reflux of 10 times of amounts, extracts 3 times, and with the extracting solution merging, concentrating under reduced pressure is dried to powder then.
6. medicated toothpaste is characterized in that including in the mastic of every double centner: the strong medicine mountain breeze extract that extracts from the strong former medicine of medicine mountain breeze of double centner, 2.2 kilograms of sodium lauryl sulphates, 35 kilograms of silicon dioxide, 16 kilograms of sorbitol, 5 kilograms of propylene glycol, 10 kilograms of glycerol, 0.5 kilogram of carrageenan, 1.0 kilograms of sodium carboxymethyl cellulose, 0.3 kilogram of saccharin sodium, 1.0 kilograms in Herba Menthae essence, 0.15 kilogram of sodium benzoate, the water of 0.15 kilogram of tetrasodium pyrophosphate and surplus; Described strong medicine mountain breeze extract is that the herb with Compositae Herba Blumeae Balsamiferae platymiscium fragrance virtue Herba Blumeae Balsamiferae is broken into 10 orders-30 purpose coarse powder, extracts 3 hours with the alcohol heating reflux of 10 times of amounts, extracts 3 times, and with the extracting solution merging, concentrating under reduced pressure is dried to powder then.
7. medicated toothpaste, it is characterized in that including in the mastic of every double centner: the strong medicine mountain breeze extract that from 53 kilograms of former medicines of strong medicine mountain breeze, extracts, 2.3 kilograms of sodium lauryl sulphates, 30 kilograms of calcium hydrogen phosphate, 20 kilograms of silicon dioxide, 20 kilograms of sorbitol, 1.3 kilograms of sodium carboxymethyl cellulose, 0.15 kilogram of saccharin sodium, smart 1 kilogram of Herba Menthae Rotundifoliae, 0.15 kilogram of sodium benzoate, the water of 0.2 kilogram of tetrasodium pyrophosphate and surplus; Described strong medicine mountain breeze extract is that the herb with Compositae Herba Blumeae Balsamiferae platymiscium fragrance virtue Herba Blumeae Balsamiferae is broken into 10 orders-30 purpose coarse powder, extracts 3 hours with the alcohol heating reflux of 10 times of amounts, extracts 3 times, and with the extracting solution merging, concentrating under reduced pressure is dried to powder then.
8. medicated toothpaste, it is characterized in that including in the mastic of every double centner: the strong medicine mountain breeze extract that from 1 kilogram of former medicine of strong medicine mountain breeze, extracts, 2.2 kilograms of sodium lauryl sulphates, 35 kilograms of calcite in powder, 10 kilograms of sorbitol, 20 kilograms of xylitol, 1.5 kilograms of guar gums, 0.2 kilogram of saccharin sodium, 1.2 kilograms of fruit essences, 0.15 kilogram of sodium benzoate, the water of 0.15 kilogram of tetrasodium pyrophosphate and surplus; Described strong medicine mountain breeze extract is that the herb with Compositae Herba Blumeae Balsamiferae platymiscium fragrance virtue Herba Blumeae Balsamiferae is broken into 10 orders-30 purpose coarse powder, extracts 3 hours with the alcohol heating reflux of 10 times of amounts, extracts 3 times, and with the extracting solution merging, concentrating under reduced pressure is dried to powder then.
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| CN 200910302560 CN101623248B (en) | 2009-05-25 | 2009-05-25 | Medicated toothpaste |
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| CN 200910302560 CN101623248B (en) | 2009-05-25 | 2009-05-25 | Medicated toothpaste |
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| CN101623248B true CN101623248B (en) | 2013-07-31 |
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Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104825350A (en) * | 2015-04-22 | 2015-08-12 | 林晓莉 | Toothpaste using plant hydrosol and essential oil to substitute essence components |
| CN106074223A (en) * | 2016-07-01 | 2016-11-09 | 贵州艾力康中草药开发有限公司 | A kind of Miao Ethnomedicine Herba Blumeae Balsamiferae toothpaste and preparation method thereof |
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| CN1857197A (en) * | 2006-03-10 | 2006-11-08 | 贵州宏宇药业有限公司 | Oral cavity cleaning bacteriostat and its preparing process |
| CN1989934A (en) * | 2005-12-26 | 2007-07-04 | 天津威欧斯生物科技发展有限公司 | Toothpaste for preventing periodontitis |
| CN101040829A (en) * | 2006-03-24 | 2007-09-26 | 云南白药集团股份有限公司 | Novel application of Yunnan Baiyao |
| CN101273960A (en) * | 2008-05-09 | 2008-10-01 | 柳州两面针股份有限公司 | Medicated toothpaste |
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2009
- 2009-05-25 CN CN 200910302560 patent/CN101623248B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1989934A (en) * | 2005-12-26 | 2007-07-04 | 天津威欧斯生物科技发展有限公司 | Toothpaste for preventing periodontitis |
| CN1857197A (en) * | 2006-03-10 | 2006-11-08 | 贵州宏宇药业有限公司 | Oral cavity cleaning bacteriostat and its preparing process |
| CN101040829A (en) * | 2006-03-24 | 2007-09-26 | 云南白药集团股份有限公司 | Novel application of Yunnan Baiyao |
| CN101273960A (en) * | 2008-05-09 | 2008-10-01 | 柳州两面针股份有限公司 | Medicated toothpaste |
Non-Patent Citations (2)
| Title |
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| 陈毅飞等.风湿壮药超微粉的消炎镇痛作用研究.《时珍国医国药》.2009,第20卷(第2期),第311-312页. |
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