CN104510665A

CN104510665A - Traditional Chinese medicinal toothpaste for inflammation preventing and pain easing

Info

Publication number: CN104510665A
Application number: CN201310709865.0A
Authority: CN
Inventors: 莫治玲
Original assignee: Individual
Current assignee: Individual
Priority date: 2013-12-21
Filing date: 2013-12-21
Publication date: 2015-04-15

Abstract

The invention discloses a traditional Chinese medicinal toothpaste for inflammation preventing and pain easing, and relates to the technical field of toothpastes. The toothpaste comprises 3-12wt% of compound traditional Chinese medicinal extract, 4-8wt% of pearl powder, 70-78wt% of calcium carbonate, 0.2-0.4wt% of carboxymethylcellulose sodium, 0.2-0.4wt% of sodium saccharin, 1.5-3wt% of sodium dodecyl sulfate, 0.5-1.5wt% of an essence, and the balance of sorbitol. The compound traditional Chinese medicinal extract comprises Dendrobium Stem extract, Callicarpa bodinieri extract and Fructus Alpiniae Oxyphyllae extract; and a raw medicine ratio of the Dendrobium Stem extract to the Callicarpa bodinieri extract to the Fructus Alpiniae Oxyphyllae extract is 5:3:3. The traditional Chinese medicinal toothpaste has substantial inflammation preventing and pain easing efficacies.

Description

Anti-inflammatory and antalgic Chinese medicinal toothpaste

Technical field

The present invention relates to Chinese medicinal toothpaste technical field, especially anti-inflammatory and antalgic Chinese medicinal toothpaste.

Background technology

Dental care product is clean and health product indispensable in people's daily life, and this series products is of a great variety, is mainly used in keeping oral cavity and cleaning of teeth, promotion breath freshening, nurses gingiva, safeguards oral cavity good environment etc.; And toothpaste indispensable cavity sanitary product in people's daily life especially; In recent years, because consumer healthcare realizes continuous enhancing, more requirement is proposed to toothpaste, also to increase some auxiliary prevention oral diseases except cleaning one's teeth, oral cavity being had to the function of nursing health effect, therefore in domestic and international toothpaste, there is various functional product and become the market mainstream, again due to the advantage that Chinese medicinal plant active component has the Western medicine such as natural, safe incomparable, therefore with the functional emphasis becoming Developing of active ingredient of Chinese herbs on market.

Summary of the invention

The problem that the present invention solves is to provide a kind of Chinese medicinal toothpaste, and this Chinese medicinal toothpaste has obvious analgesic effect.

In order to solve the problems of the technologies described above, the technical solution adopted in the present invention is: the percentage by weight of its component is as follows:

Compound Chinese medicine extract 3%-12%; Wetting agent 21%-30%; Guar gum 0.3%-0.6; Carboxymethyl cellulose acid sodium 0.6%1.2%; Saccharin sodium 0.2%-0.3%; Caries preventive agent 0.01%-0.05%, freshener 1.0%-1.2%; Sodium lauryl sulphate 2.0%-2.5%; Calcium hydrogen phosphate 35%-40%; Antiseptic 0.13%-0.15%; Pure water surplus;

Described compound Chinese medicine extract is golden hairpin dendrobium extract, Folium Callicarpae Formosanae extract, Fructus Alpiniae Oxyphyllae extract; Described white golden hairpin dendrobium extract: Folium Callicarpae Formosanae extract: the former medicine of Fructus Alpiniae Oxyphyllae extract is than being 5:3:3.

In technique scheme, scheme can also be more specifically: described wetting agent is the mixture of sorbitol, glycerol, and described sorbitol accounts for the 16%-20% of total mastic, and described glycerol accounts for the 5%-10% of total mastic; Described freshener is edible essence or Mentholum; Described caries preventive agent is sodium fluoride; Described antiseptic is nipalgin mixed ester sodium.

Dendrobium nobile of the present invention is perennial herb, for consumption of body fluid caused by febrile disease, thirsty dryness of the tongue, after being ill deficiency-heat, gastropathy, retch, the few tongue of tongue light.Have strengthen immunity, the beneficial essence of reinforcing YIN-essence, nourishing the stomach of promoting the production of body fluid, nourishing the lung to arrest cough, nourishing YIN and clearing away heat, promoting the production of body fluid to quench thirst, for consumption of body fluid caused by febrile disease, thirsty dryness of the tongue, after being ill deficiency-heat, anticancer, reinforcing stomach reg fluid, nourishing YIN and clearing away heat, liver heat removing, improving eyesight, adjusting blood lipid, blood sugar lowering etc.Special efficacy is had to cardiovascular and cerebrovascular vessel, digestive system and respiratory system, ophthalmology etc.

Folium Callicarpae Formosanae of the present invention, be belong to Verenaceae, Callicarpa perennial fast-growing shrub medical material, root, stem, leaf, flower, seed all can be used as medicine, and have heat-clearing and toxic substances removing, cooling blood for hemostasis, dephlogistication and promoting nuscle growth, the function such as anticancer; (" Fujian traditional herbal medicine ") is recorded, and controls postextraction hemorrhage more than, and available sterilization Cotton Gossypii dips in Folium Callicarpae Formosanae last plug; Folium Callicarpae Formosanae can make bleeding time and reduced clotting time, and its hemostasis principle may be that it makes vasoconstriction and platelet count is increased.

Fructus Alpiniae Oxyphyllae of the present invention, perennial herb, high 1-3m.Petiole is short; Blade lanceolar, long 20-30cm, wide 3-6cm, tip shape of tail is gradually sharp, the wide wedge shape of base portion, edge tool deciduous setula, and the residual trace of base is serration shape, and two sides is without hair; Containing abundant vitamin B group and vitamin C in Fructus Alpiniae Oxyphyllae, and trace element manganese, zinc, potassium, sodium, calcium, magnesium, phosphorus, ferrum and copper etc., show that Fructus Alpiniae Oxyphyllae has the multiple pharmacological effect such as antibacterial, antiinflammatory and analgesia.

Use with the form of Dendrobium nobile, Folium Callicarpae Formosanae and Fructus Alpiniae Oxyphyllae three taste compound Chinese medicine extract in the present invention, the extracting method of white golden hairpin dendrobium extract of the present invention, Folium Callicarpae Formosanae extract and Fructus Alpiniae Oxyphyllae extract is that every taste Chinese medicine is broken into fine powder, cross 150 mesh sieves, 3 hours are extracted with the alcohol heating reflux of 10 times amount, extract 3 times, then extracting solution concentrating under reduced pressure become extractum or be dried to powdery; Extracting method is not limited to said method, and the additive method such as supercritical extraction, ultrasonic extraction also can be adopted to extract.

Prove through overtesting, add using golden hairpin dendrobium extract, Folium Callicarpae Formosanae extract, Fructus Alpiniae Oxyphyllae extract as active ingredient of Chinese herbs in this toothpaste, to tooth, there is obvious anti-inflammatory and analgesic effect.

Detailed description of the invention

Below in conjunction with embodiment, the present invention will be further described.In following each embodiment, involved percentage ratio except as otherwise noted, is all calculate by weight percentage.

Embodiment 1-5: using golden hairpin dendrobium extract, Folium Callicarpae Formosanae extract, Fructus Alpiniae Oxyphyllae extract as the Chinese medicinal toothpaste of compound Chinese medicine extract, white golden hairpin dendrobium extract: Folium Callicarpae Formosanae extract: the former medicine of Fructus Alpiniae Oxyphyllae extract is than being 5:3:3.

The Chinese medicinal toothpaste constitutive material of embodiment 1-5 and weight percent content are as following table:

clinical trial part:

(1) to the antiinflammatory action of white mice:

1, sample:

Be added with golden hairpin dendrobium extract, Folium Callicarpae Formosanae extract, the toothpaste (embodiment 1, embodiment 3, embodiment 4) of Fructus Alpiniae Oxyphyllae extract, toothpaste bare substrate, benzoic acid ointment, blank (normal saline)

2, method and process:

3, xylol causes the antiinflammatory action of white mice ear corridor acute inflammation swelling

Choose healthy Kun Ming mice 40, be divided into 5 groups at random, often organize 8, male and female half and half.During experiment, often organize two sides inside and outside every animal auris dextra corridor and all smear dimethylbenzene 0.1ml/ only to scorching, left ear does not add process and does self-blank matched group.After smearing dimethylbenzene 25min, often organize uniform application group tested material sample 0.1g/ respectively, two sides inside and outside every animal auris dextra corridor.After giving tested material 1h, the dislocation of white mice strength vertebra is put to death, and cuts two ear corridors, washes away auris dextra corridor tested material sample, clean with dry cotton ball with normal saline, and get two circle auricles with card punch at same position cutter, it is swelling value that auris dextra sheet weight deducts left auricle weight.

result:

4, conclusion:anti-inflammatory and antalgic Chinese medicinal toothpaste contains golden hairpin dendrobium extract, Folium Callicarpae Formosanae extract, Fructus Alpiniae Oxyphyllae extract active additive, white mice acute inflammation swelling ear corridor quality can be made significantly to alleviate, white mice ear corridor acute inflammation swelling caused by obvious suppression dimethylbenzene, shows that anti-inflammatory and antalgic Chinese medicinal toothpaste has obvious antiinflammatory action to acute inflammation.

(2) to the analgesic test of white mice

Get Kun Ming mice 60, be divided into 6 groups at random, often organize ten, male and female half and half.Negative control group gives isopyknic distilled water, and other groups give the active additive of the toothpaste prepared by embodiment 1-5, and each dosage is 0.1g/, every day 1 time, for three days on end.After last administration, 30min concentration is the acetic acid normal saline 0.1ml on an empty stomach injection of 0.7%, observes the writhing number of times of white mice in 15min, and contrasts group difference.

Result:

**P<0.05.

Conclusion: the active additive containing golden hairpin dendrobium extract, Folium Callicarpae Formosanae extract, Fructus Alpiniae Oxyphyllae extract in this anti-inflammatory and antalgic Chinese medicinal toothpaste obviously can reduce the writhing number of times produced after white mice watches analgesics attentively, has obvious analgesic activity.

Claims

1. an anti-inflammatory and antalgic Chinese medicinal toothpaste, is characterized in that the component comprising following percentage by weight:

Compound Chinese medicine extract 3%-12%; Wetting agent 21%-30%; Guar gum 0.3%-0.6; Carboxymethyl cellulose acid sodium 0.6%-1.2%; Saccharin sodium 0.2%-0.3%; Caries preventive agent 0.01%-0.05%, freshener 1.0%-1.2%; Sodium lauryl sulphate 2.0%-2.5%; Calcium hydrogen phosphate 35%-40%; Antiseptic 0.13%-0.15%; Pure water surplus;

2. anti-inflammatory and antalgic Chinese medicinal toothpaste according to claim 1, is characterized in that: described wetting agent is the mixture of sorbitol, glycerol, and described sorbitol accounts for the 16%-20% of total mastic, and described glycerol accounts for the 5%-10% of total mastic; Described freshener is edible essence or Mentholum; Described caries preventive agent is sodium fluoride; Described antiseptic is nipalgin mixed ester sodium.