CN103520052A - Application of hyacinth bletilla extract in preparing oral care product - Google Patents
Application of hyacinth bletilla extract in preparing oral care product Download PDFInfo
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- CN103520052A CN103520052A CN201310489651.7A CN201310489651A CN103520052A CN 103520052 A CN103520052 A CN 103520052A CN 201310489651 A CN201310489651 A CN 201310489651A CN 103520052 A CN103520052 A CN 103520052A
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Abstract
The invention discloses application of a hyacinth bletilla extract in preparing an oral care product, i.e. the hyacinth bletilla extract is added into the oral care product as an active component for preventing and treating gingival bleeding in an oral care product preparation technique. Compared with the prior art, the oral care product prepared from the hyacinth bletilla extract has obvious effects of preventing and treating gingival bleeding.
Description
Technical field
The present invention relates to oral care implement technical field, the application of especially a kind of Pseudobulbus Bletillae (Rhizoma Bletillae) extract in preparing oral care product.
Background technology
The conventional oral care product of people is mainly toothpaste, collutory, dentifrice etc., and its basic function is exactly cleaning teeth, and protection gingiva, safeguards the hygiene and health in oral cavity.Raising along with people's living standard, the health care consciousness of consumer constantly strengthens, oral care product has also been proposed to more requirement, people have also increased some except having this basic function that cleans the teeth to the requirement of toothpaste and collutory can assist the effect of prevention oral disease, therefore, toothpaste in the market and collutory almost all add the functional component for the various oral diseases of control, therefore the product that oral care product both domestic and external has various functional types has become the market mainstream, is wherein to add western medicine composition to realize mostly.
But along with economic development, be accompanied by day by day manifesting of the problems such as environmental pollution, ecological disturbance, consumer more and more pays close attention to the safety of product, thereby more and more advocates natural and safe product.Interpolation can effectively prevent and treat the oral care product of various oral disease Chinese herbal medicine, little with its toxic and side effects, features such as green, environmental protection, safety height and be doubly subject to people's favor, and on market, the consumption demand of this series products is in continuous growth.In addition, along with the development of modernization of Chinese medicine technology, the method for Chinese medicine study of active components utilization has also been obtained to fine development, this assists prevention oral disease that good technical support is provided for oral care product utilizes active ingredient of Chinese herbs.
Gingival hemorrhage is one of department of stomatology common sympton, refers to that gingiva is idiopathic or due to bleeding on a small quantity that minimal irritation causes.The lighter only shows as sucking, brush teeth, while chewing harder food in saliva with the blood streak, severe one is hemorrhage more even hematostaxis when gingiva is subject to minimal irritation.Generally speaking, the chronic inflammatory disease of gingiva is the common cause of gingival hemorrhage, therefore gingival hemorrhage is more common in periodontitis and gingivitis patients.According to interrelated data, show, due to bad dietary habit and think little of oral hygiene, at different times, there is gingival hemorrhage in various degree in increasing crowd, for this reason, be necessary to comply with the needs of market development, the Chinese herbal medicine extract safely and effectively of usining is developed a kind of oral care product of special control gingival hemorrhage as active component.
Summary of the invention
The problem that the present invention solves is to provide the application scheme of Pseudobulbus Bletillae (Rhizoma Bletillae) extract in preparing oral care product, and this oral cavity nursing health products has obvious anastalsis.
The application scheme of Pseudobulbus Bletillae (Rhizoma Bletillae) extract of the present invention in preparing oral care product is exactly Pseudobulbus Bletillae (Rhizoma Bletillae) extract to be usingd to the form of single medicinal material in preparing the technique of oral care implement to join in oral care product as the active component of anastalsis.
In technique scheme, scheme can also be more specifically: described Bletilla in preparing toothpaste technique as the raw material of anastalsis.
Further: the percentage by weight of described Bletilla in total mastic of toothpaste is 1.0-10.0%, and described Bletilla is Pseudobulbus Bletillae (Rhizoma Bletillae) ethanol extraction.
Further: described Bletilla in preparing collutory technique as the raw material of anastalsis.
Further: the percentage by weight of described Bletilla in collutory raw material is 1.0-10.0%, described Bletilla is Pseudobulbus Bletillae (Rhizoma Bletillae) ethanol extraction.
Further: described Bletilla in preparing dentifrice technique as the raw material of anastalsis.
Further: the percentage by weight of described Bletilla in dentifrice raw material is 1.0-10.0%, described Bletilla is Pseudobulbus Bletillae (Rhizoma Bletillae) ethanol extraction.
Further: described Bletilla in preparing throat lozenge technique as the raw material of anastalsis.
Further: the percentage by weight of described Bletilla in throat lozenge raw material is 1.0-10.0%, described Bletilla is Pseudobulbus Bletillae (Rhizoma Bletillae) ethanol extraction.
Further: described Bletilla in preparing chewing gum technique as the raw material of anastalsis.
Further: the percentage by weight of described Bletilla in chewing-gum material is 1.0-10.0%, described Bletilla is Pseudobulbus Bletillae (Rhizoma Bletillae) ethanol extraction.
The said Pseudobulbus Bletillae (Rhizoma Bletillae) of the present invention is is the dry stem piece of orchid Pseudobulbus Bletillae (Rhizoma Bletillae) Bletilla striata (Thund.) Reichb. f..Nature and flavor are pungent, bitter, sweet, puckery, are slightly cold.Return lung, liver, stomach warp.Major function astringing to arrest bleeding, detumescence and promoting granulation.Be mainly used in treating hemoptysis and spit blood, traumatic hemorrhage, sore swollen toxin, chapped skin; Pulmonary tuberculosis hemoptysis, ulcer haemorrhage.
The mentioned Pseudobulbus Bletillae (Rhizoma Bletillae) of the present invention is the dry root of the rosaceous plant Pseudobulbus Bletillae (Rhizoma Bletillae) or the Pseudobulbus Bletillae (Rhizoma Bletillae) that comes into leaves.
In the present invention, be to use with the form of Pseudobulbus Bletillae (Rhizoma Bletillae) extract, Pseudobulbus Bletillae (Rhizoma Bletillae) extract extracting method is that the Pseudobulbus Bletillae (Rhizoma Bletillae) is broken into granularity, with the alcohol heating reflux of 10 times of amounts, extracts 3 hours, extracts 3 times, then extracting solution concentrating under reduced pressure is become to extractum or is dried to powdery.The extracting method of the Pseudobulbus Bletillae (Rhizoma Bletillae) is not limited to said method, also can adopt the additive methods such as supercritical extraction, ultrasonic extraction to extract; Also can use existing commercially available Bletilla.
It is example that the content of the Pseudobulbus Bletillae (Rhizoma Bletillae) extract described in the present invention all be take the pure extract powder that active component is 100%, but is not limited to pure extract powder, can be also other forms such as extracting solution or extractum; When being applied to toothpaste with other forms as extracting solution, the addition in formula should be converted to the amount of disclosed pure form of extract in the present invention.
The present invention confirms through pharmacological evaluation, and the oral care product that contains Pseudobulbus Bletillae (Rhizoma Bletillae) extract has the effect of significant control gingival hemorrhage, antiinflammatory.
The present invention carries out the anastalsis experiment of laboratory animal white rabbit liver local woanded surface bleeding due to trauma to the toothpaste containing Pseudobulbus Bletillae (Rhizoma Bletillae) extract, make positive control and blank simultaneously and observe.Experimental result shows, this Pseudobulbus Bletillae (Rhizoma Bletillae) extract toothpaste and positive control medicine YUNNAN BAIYAO, with the comparison of blank group, all have obvious anastalsis to rabbit liver local woanded surface bleeding due to trauma, there were significant differences statistically, shows that this Pseudobulbus Bletillae (Rhizoma Bletillae) extract toothpaste has significant anastalsis.
The specific embodiment
Below in conjunction with embodiment, the present invention will be further described.In following each embodiment, related percentage ratio except as otherwise noted, is all to calculate by weight percentage.
embodiment 1-5: the application of Pseudobulbus Bletillae (Rhizoma Bletillae) extract in toothpaste.
the toothpaste constitutive material of embodiment 1-5 and weight percent content are as following table:
the toothpaste preparation technology of embodiment 2 adopts the one-step method preparation of conventional medicine toothpaste:
the liquid materials such as the pure water that input measures in temporary cylinder, sorbitol, Pseudobulbus Bletillae (Rhizoma Bletillae) extract; In pre-dispersed still, drop into the calcite in powder, saccharin sodium sodium, carboxycellulose sodium, sodium lauryl sulphate, the nipalgin that measure and mix the powders such as ester sodium, carry out pre-dispersed, mixing; Open cream still vacuum pump processed and suck above-mentioned liquid material; Then open scraper, enter above-mentioned powder, drive agitator and colloid mill, after 50 minutes, drop into essence, close successively colloid mill, agitator, scraper after 10 minutes, vacuum breaker, stops vacuum pump, after sampling detection is qualified, makes.
the preparation method of above-mentioned other embodiment is with reference to embodiment 2.
embodiment 6-10: the application of Pseudobulbus Bletillae (Rhizoma Bletillae) extract in collutory.
the collutory constitutive material of embodiment 6-10 and weight percent content are as following table:
The preparation method of above-described embodiment 7 collutorys is:
First Pseudobulbus Bletillae (Rhizoma Bletillae) extract, nipalgin mixed ester sodium are added stirring and dissolving in edible ethanol to be placed in temporary pot, sorbitol, deionization, castor oil hydrogenated-40 are added in agitated kettle and stirred 10 minutes, alcoholic solution in temporary pot is added in agitated kettle and stirred 10 minutes, finally add essence to stir 5 minutes, stop stirring, after sampling detection is qualified, make.
The preparation method of the collutory of above-mentioned other embodiment is with reference to embodiment 7.
Embodiment 11-15: the application of Pseudobulbus Bletillae (Rhizoma Bletillae) extract in dentifrice.
The dentifrice constitutive material of embodiment 11-15 and weight percent content are as following table:
In above-described embodiment 12; after natural whiting, sodium carboxymethyl cellulose, sodium lauryl sulphate, saccharin sodium sodium are weighed up by formula consumption, add in mixing agitator and stir after 20 minutes and add Pseudobulbus Bletillae (Rhizoma Bletillae) extract to stir 10 minutes; finally add essence, sorbitol to stir after 20 minutes and shut down, after sampling detection is qualified, make.
In above-described embodiment 13; after calcium phosphate dibasic dihydrate, silicon dioxide, sodium carboxymethyl cellulose, saccharin sodium sodium, sodium lauryl sulphate, nipalgin mixed ester sodium are weighed up by formula consumption, add in mixing agitator and stir after 20 minutes; add Pseudobulbus Bletillae (Rhizoma Bletillae) extract to stir 10 minutes; finally add essence, sorbitol to stir after 20 minutes and shut down, after sampling detection is qualified, make.
Embodiment 11 is with reference to executing example 12, and other embodiment, with reference to executing example 13.
Embodiment 16-20: the application of Pseudobulbus Bletillae (Rhizoma Bletillae) extract in throat lozenge.
The throat lozenge constitutive material of embodiment 16-20 and weight percent content are as following table:
The preparation technology of above-described embodiment adopts existing throat lozenge production technology.
Embodiment 21-25: the application of Pseudobulbus Bletillae (Rhizoma Bletillae) extract in chewing gum.
The chewing gum constitutive material of embodiment 21-25 and weight percent content are as following table:
The preparation technology of above-described embodiment adopts existing chewing gum production technology.
clinical trial part:
the anastalsis pharmacological experiment of Pseudobulbus Bletillae (Rhizoma Bletillae) extract toothpaste;
get 55 of healthy white rabbit, body weight 2.0～2.5kg, male and female dual-purpose.With 3% pentobarbital sodium 30mg/kg auricular vein, slowly inject, after family's rabbit anesthesia, lie on the back and be fixed on operating-table, abdominal part median incision is about 6～8cm, and exposure fixedly liver, cut liver organization with operating scissors at leftlobe of liver and be about 1cm, wide about 1cm, high about 1cm, it is hemorrhage that wound surface is injection sample.Wipe after the blood of ejection, at the local spreading of wound surface matter sample 1g to be tried, gauze is topped immediately, with 200g counterweight compressing 1min, after 1min, remove counterweight, observe haemostatic effect, take not hemorrhage is hemostasis, as still hemorrhage, add spreading and after trying matter sample, continue pressurization, every 30s, observe once, record bleeding stopping period, as still hemorrhage in surpassed 3min, be designated as and fail to stop blooding, bleeding stopping period is designated as > 3min.After each sample test, with 37 ℃ of normal saline, wash away residual tested material, make wound surface again hemorrhage, then test next tested material sample.Every rabbit carries out liver local woanded surface damage hemostasis test experiments four times, and each tested material sample is pressed the drug of topical application of Latin square program, to reduce the impact of liver local woanded surface damage otch difference and medication order.Blank group, the blank matrix group of toothpaste, positive drug YUNNAN BAIYAO group, Pseudobulbus Bletillae (Rhizoma Bletillae) toothpaste sample group.Each tested material sample amounts to the hemostasis experiment of carrying out 20 rabbit liver local woanded surface bleeding due to traumies.Haemostatic effect is designated as score value F by scoring method reciprocal (10/T), and 3min fails to stop blooding above, and F is designated as 0 without score value.Record and carry out statistics t check, the results are shown in Table 1:
experimental result shows, Pseudobulbus Bletillae (Rhizoma Bletillae) toothpaste sample group and YUNNAN BAIYAO group all have obvious haemostatic effect to rabbit liver local woanded surface bleeding due to trauma, show that Pseudobulbus Bletillae (Rhizoma Bletillae) toothpaste sample group and YUNNAN BAIYAO group have obvious anastalsis,
conclusion: the sample sets containing Pseudobulbus Bletillae (Rhizoma Bletillae) extract toothpaste all has obvious haemostatic effect to rabbit liver local woanded surface bleeding due to trauma, has obvious anastalsis.
Claims (11)
1. the application of Pseudobulbus Bletillae (Rhizoma Bletillae) extract in preparing oral care product, in preparing the technique of oral care implement, Pseudobulbus Bletillae (Rhizoma Bletillae) extract is usingd single medicinal material form as control gingival hemorrhage active component add in oral care product.
2. the application of Pseudobulbus Bletillae (Rhizoma Bletillae) extract according to claim 1 in preparing oral care product, is characterized in that: described Bletilla in preparing toothpaste technique as the raw material of anastalsis.
3. the application of Pseudobulbus Bletillae (Rhizoma Bletillae) extract according to claim 2 in preparing oral care product, it is characterized in that: the percentage by weight of described Bletilla in total mastic of toothpaste is 1.0-10.0%, and described Bletilla is Pseudobulbus Bletillae (Rhizoma Bletillae) ethanol extraction.
4. the application of Pseudobulbus Bletillae (Rhizoma Bletillae) extract according to claim 1 in preparing oral care product, is characterized in that: described Bletilla in preparing collutory technique as the raw material of anastalsis.
5. the application of Pseudobulbus Bletillae (Rhizoma Bletillae) extract according to claim 4 in preparing oral care product, it is characterized in that: the percentage by weight of described Bletilla in collutory raw material is 1.0-10.0%, described Bletilla is Pseudobulbus Bletillae (Rhizoma Bletillae) ethanol extraction.
6. the application of Pseudobulbus Bletillae (Rhizoma Bletillae) extract according to claim 1 in preparing oral care product, is characterized in that: described Bletilla in preparing dentifrice technique as the raw material of anastalsis.
7. the application of Pseudobulbus Bletillae (Rhizoma Bletillae) extract according to claim 6 in preparing oral care product, is characterized in that: the percentage by weight of described Bletilla in dentifrice raw material is 1.0-10.0%, and described Bletilla is Pseudobulbus Bletillae (Rhizoma Bletillae) ethanol extraction.
8. the application of Pseudobulbus Bletillae (Rhizoma Bletillae) extract according to claim 1 in preparing oral care product, is characterized in that: described Bletilla in preparing throat lozenge technique as the raw material of anastalsis.
9. the application of Pseudobulbus Bletillae (Rhizoma Bletillae) extract according to claim 8 in preparing oral care product, it is characterized in that: the percentage by weight of described Bletilla in throat lozenge raw material is 1.0-10.0%, described Bletilla is Pseudobulbus Bletillae (Rhizoma Bletillae) ethanol extraction.
10. the application of Pseudobulbus Bletillae (Rhizoma Bletillae) extract according to claim 1 in preparing oral care product, is characterized in that: described Bletilla in preparing chewing gum technique as the raw material of anastalsis.
11. application of Pseudobulbus Bletillae (Rhizoma Bletillae) extract according to claim 10 in preparing oral care product, it is characterized in that: the percentage by weight of described Bletilla in chewing-gum material is 1.0-10.0%, described Bletilla is Pseudobulbus Bletillae (Rhizoma Bletillae) ethanol extraction.
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Cited By (11)
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| CN104013547A (en) * | 2014-05-26 | 2014-09-03 | 皖南医学院 | Toothpaste for stopping bleeding, brightening and refreshing breath and preparation method thereof |
| CN104997701A (en) * | 2015-08-17 | 2015-10-28 | 杭州华胄科技有限公司 | Oral care product containing bletilla striata alcohol extract and having anti-Hp (helicobacter pylori) efficacy |
| CN105168086A (en) * | 2014-09-10 | 2015-12-23 | 上海百念商贸有限公司 | Traditional Chinese medicine composition, compound particles containing traditional Chinese medicine composition, toothpaste and preparation method of toothpaste |
| CN105534805A (en) * | 2016-01-11 | 2016-05-04 | 广西大学 | Antibacterial and astringent Chinese herb toothpaste |
| CN106137853A (en) * | 2016-08-17 | 2016-11-23 | 林少英 | A kind of fresh breath toothpaste |
| CN106177465A (en) * | 2016-08-24 | 2016-12-07 | 成都体九生物科技有限公司 | Toothpaste containing Radix Notoginseng extract and Pseudobulbus Bletillae (Rhizoma Bletillae) extract and preparation method thereof |
| CN106511423A (en) * | 2016-12-15 | 2017-03-22 | 柳州两面针股份有限公司 | Application of annual fleabane herb extract in preparation of mouth care health product |
| CN107242993A (en) * | 2017-06-23 | 2017-10-13 | 王会海 | A kind of spearmint ferment mouthwash and preparation method thereof |
| CN107811941A (en) * | 2017-11-21 | 2018-03-20 | 丹东欣时代生物医药科技有限公司 | One kind shield gum toothpaste |
| CN109260125A (en) * | 2018-11-30 | 2019-01-25 | 俞傲然 | A kind of powder of brushing teeth that can effectively control bleeding gums, be good for tooth, permanent tooth |
| CN114848561A (en) * | 2022-07-07 | 2022-08-05 | 云南诺特金参口腔护理用品有限公司 | Toothpaste for preventing and treating dental ulcer and preparation method thereof |
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Cited By (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104013547A (en) * | 2014-05-26 | 2014-09-03 | 皖南医学院 | Toothpaste for stopping bleeding, brightening and refreshing breath and preparation method thereof |
| CN105168086A (en) * | 2014-09-10 | 2015-12-23 | 上海百念商贸有限公司 | Traditional Chinese medicine composition, compound particles containing traditional Chinese medicine composition, toothpaste and preparation method of toothpaste |
| CN104997701A (en) * | 2015-08-17 | 2015-10-28 | 杭州华胄科技有限公司 | Oral care product containing bletilla striata alcohol extract and having anti-Hp (helicobacter pylori) efficacy |
| CN105534805B (en) * | 2016-01-11 | 2018-10-19 | 广西大学 | A kind of Chinese herbal toothpaste of antibacterial anti hemorrhagic |
| CN105534805A (en) * | 2016-01-11 | 2016-05-04 | 广西大学 | Antibacterial and astringent Chinese herb toothpaste |
| CN106137853A (en) * | 2016-08-17 | 2016-11-23 | 林少英 | A kind of fresh breath toothpaste |
| CN106177465A (en) * | 2016-08-24 | 2016-12-07 | 成都体九生物科技有限公司 | Toothpaste containing Radix Notoginseng extract and Pseudobulbus Bletillae (Rhizoma Bletillae) extract and preparation method thereof |
| CN106511423A (en) * | 2016-12-15 | 2017-03-22 | 柳州两面针股份有限公司 | Application of annual fleabane herb extract in preparation of mouth care health product |
| CN107242993A (en) * | 2017-06-23 | 2017-10-13 | 王会海 | A kind of spearmint ferment mouthwash and preparation method thereof |
| CN107242993B (en) * | 2017-06-23 | 2020-07-31 | 王会海 | Spearmint enzyme mouthwash and preparation method thereof |
| CN107811941A (en) * | 2017-11-21 | 2018-03-20 | 丹东欣时代生物医药科技有限公司 | One kind shield gum toothpaste |
| CN109260125A (en) * | 2018-11-30 | 2019-01-25 | 俞傲然 | A kind of powder of brushing teeth that can effectively control bleeding gums, be good for tooth, permanent tooth |
| CN114848561A (en) * | 2022-07-07 | 2022-08-05 | 云南诺特金参口腔护理用品有限公司 | Toothpaste for preventing and treating dental ulcer and preparation method thereof |
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