CN102961295B - Application of caulis sinomenii extract to preparation of oral care products - Google Patents
Application of caulis sinomenii extract to preparation of oral care products Download PDFInfo
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- CN102961295B CN102961295B CN201210542412.9A CN201210542412A CN102961295B CN 102961295 B CN102961295 B CN 102961295B CN 201210542412 A CN201210542412 A CN 201210542412A CN 102961295 B CN102961295 B CN 102961295B
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Abstract
The invention discloses an application of a caulis sinomenii extract to the preparation of oral care products, relating to the technical field of oral care. In the process of preparing oral care products, the caulis sinomenii extract is used as an ancillary drug raw material with an analgesic effect to be added in the oral care products; in the oral care products such as toothpaste, mouth wash, tooth powder, throat lozenge, chewing gum and the like, the caulis sinomenii extract is not only safe in use, but also has an obvious analgesic effect.
Description
Technical field
The present invention relates to oral care techniques field, especially a kind of oral cavity nursing health products with control tooth, gingiva pain.
Background technology
The oral care product that people commonly use is toothpaste, collutory, dentifrice, throat lozenge, chewing gum etc. mainly, and its basic function is exactly cleaning teeth, and protection gingiva, safeguards the hygiene and health in oral cavity.Along with the raising of people's living standard, the health care consciousness of consumer constantly strengthens, more requirement be it is also proposed to oral care product, the requirement of people to toothpaste and collutory also add effect that some can assist prevention oral disease except having this basic function that cleans the teeth, therefore, toothpaste in the market and collutory almost all add the functional component for the various oral disease of control, therefore the product that oral care product both domestic and external has a various functional type becomes the market mainstream, is mostly wherein to add western medicine composition to realize.
But along with the development of economy, along with day by day manifesting of the problem such as environmental pollution, ecological disturbance, the safety of consumer to product is more and more paid close attention to, thus more and more advocates natural and safe product.Interpolation effectively can prevent and treat the oral care product of various oral disease Chinese herbal medicine, little with its toxic and side effects, and green, environmental protection, safety high and be doubly subject to the favor of people, on market, the consumption demand of this series products is in continuous growth.In addition, along with the development of modernization of Chinese medicine technology, have also been obtained fine development to the method that Chinese medicine study of active components utilizes, this prevents oral disease to provide good technical support for oral care product utilizes active ingredient of Chinese herbs to assist.
Toothache is the oral disease caused by many reasons, show according to interrelated data, China has the consumer more than more than 50% to there is toothache in various degree at different times, but domestic market does not still have a this oral disease of special control and has the oral care implement of obvious effect.
Summary of the invention
The problem that the present invention solves is to provide Caulis Sinomenii extract and is preparing the application scheme in oral cavity nursing health products, and this oral cavity nursing health products has obvious analgesic activity.
Caulis Sinomenii extract of the present invention is exactly joined in the oral cavity nursing health products such as toothpaste, collutory, dentifrice, throat lozenge, chewing gum by the ancillary drug raw material of Caulis Sinomenii extract as analgesic activity in the technique preparing oral cavity nursing health products preparing the application scheme in oral cavity nursing health products.
In technique scheme, described Caulis Sinomenii extract can join in toothpaste as the ancillary drug raw material of analgesic activity, and the percentage by weight of described Caulis Sinomenii extract in total mastic of toothpaste is 5 ~ 15%.
In such scheme, described Caulis Sinomenii extract can join in collutory as the ancillary drug raw material of analgesic activity, and the percentage by weight of described Caulis Sinomenii extract in the raw material of collutory is 5 ~ 15%.
In such scheme, described Caulis Sinomenii extract joins in dentifrice as the ancillary drug raw material of analgesic activity, and the percentage by weight of described Caulis Sinomenii extract in dentifrice raw material is 5 ~ 15%.
In such scheme, described Caulis Sinomenii extract joins in throat lozenge as the ancillary drug raw material of analgesic activity, and the percentage by weight of described Caulis Sinomenii extract in throat lozenge raw material is 5 ~ 15%.
In such scheme, described Caulis Sinomenii extract joins in chewing gum as the ancillary drug raw material of analgesic activity, and the percentage by weight of described Caulis Sinomenii extract in chewing-gum material is 5 ~ 15%.
The said Caulis Sinomenii of the present invention is the dry rattan of menispermaceous plants Sinomenium acutum Sinomenium acutum (Thunb.) Rehd. et Wils. and hair Sinomenium acutum Sinomenium acutum (Thunb.) Rehd. et Wils. var. cinereum Rehd. et Wils..Nature and flavor are bitter, pungent, flat.Return liver, spleen channel.Its major function is Eradicates rheumatism, the meridian dredging, and diuresis, pain relieving, can be used for rheumatic arthralgia, arthroncus, paralysis pruritus and pain relieving etc.
Extracting method is by broken for Caulis Sinomenii granulating, extracts 3 hours, extract 3 times, then extracting solution concentrating under reduced pressure is dried to powdery with the alcohol heating reflux of 10 times amount.
The extracting method of Caulis Sinomenii of the present invention is not limited to said method, and the additive method such as supercritical extraction, ultrasonic extraction also can be adopted to extract; Also existing commercially available Chinese medicine Caulis Sinomenii extract can be used.
The content of the Caulis Sinomenii extract described in the present invention is all the pure extract powder of 100% for active component, but is not limited to pure extract powder, also can be other form such as extracting solution or extractum.In time being applied to oral care product with other forms as extracting solution, the addition in formula should be converted to the amount of pure form of extract disclosed in the present invention.
Oral cavity nursing health products in the present invention is applied to wherein with the form of single medicinal material by Chinese medicine Caulis Sinomenii.
Mouth care health product of the present invention adds the raw material not only use safety of Caulis Sinomenii extract as natural plant active component in preparation process, and has obvious analgesic activity.
Adopt toothpaste sample of the present invention to the analgesic activity (hot plate method) of white mice; Choose body weight 18 ~ 22g healthy Kunming kind ♀ white mice, with GJ-8402 type hot plate dolorimeter, regulable control temperature is at 55 ± 0.5 DEG C, white mice is placed on the pain threshold (white mice contact hot plate is to the time of licking metapedes) hot plate measuring every Mus, allly lick the metapedes time and be less than 5 seconds (S) or be greater than 30 seconds (S) and leaper gives it up, select qualified white mice 40, divide equally 4 groups at random, often organize 10.Blank group, toothpaste bare substrate group, positive drug diclofenac diethylamine emulgel group, Caulis Sinomenii toothpaste sample group.Each group of white mice repeats the normal pain threshold that 2 times measure white mice by the same method, and every minor tick 15min, gets twice normal pain threshold meansigma methods, as the pain threshold before this group white mice administration.Be coated with respectively at the sufficient sole of the foot of the every Mus of each treated animal 4 and only give corresponding tested material 0.2g/, blank group is coated with only gives normal saline 0.2ml/, be coated with 15min, 30min, 45min after giving tested material and measure the pain threshold of white mice by the same method respectively, as still reactionless in white mice 60 seconds (S), white mice is taken out, in order to avoid scald, its pain threshold calculates with 60 seconds (s), record each group of white mice pain threshold, data carry out statistics t inspection, the results are shown in Table 1.
Table 1 containing Caulis Sinomenii extract toothpaste sample to the analgesic activity (hot plate method) of white mice (
± S, n=10)
Note: compare with before administration: * P < 0.05, * * P < 0.01, △ P > 0.05;
Compare with blank group: #P < 0.05, ##P < 0.01, ▲ P > 0.05;
Compare with toothpaste bare substrate group: b P < 0.01
Experimental result shows: containing Caulis Sinomenii extract toothpaste sample group and diclofenac diethylamine emulgel group with before administration and blank group compare, all can significantly improve white mice pain threshold; Compare with toothpaste bare substrate group containing Caulis Sinomenii extract toothpaste sample group, white mice pain threshold can be significantly improved, show, containing Caulis Sinomenii extract toothpaste sample group, there is obvious analgesic activity.
Detailed description of the invention
Below in conjunction with embodiment, the present invention will be further described, and in following each embodiment, involved percentage ratio except as otherwise noted, is all calculate by weight percentage.
Embodiment 1 ~ 5: the application of Caulis Sinomenii extract in toothpaste
Toothpaste constitutive material in embodiment 1 to embodiment 5 and weight percent content are as following table 2:
The preparation method of toothpaste in embodiment 1:
Lotion of toothpaste can adopt the one-step method cream production technology of conventional medicine toothpaste to make: in temporary cylinder, drop into the liquid material such as pure water, sorbitol, Caulis Sinomenii extract measured; In pre-dispersed still, drop into the calcite in powder, saccharin sodium, carboxycellulose sodium, sodium lauryl sulphate, the nipalgin that measure mix the powders such as ester sodium, carry out pre-dispersed, mixing; Open cream still vacuum pump processed and suck above-mentioned liquid material; Then open scraper, enter above-mentioned powder, drive agitator and colloid mill, after 50 minutes, drop into essence, close colloid mill, agitator, scraper successively after 10 minutes, vacuum breaker, stop vacuum pump, make after sampling detection is qualified.
The production technology of embodiment 2 to embodiment 5 is with reference to embodiment 1.
Embodiment 6 ~ 10: the application of Caulis Sinomenii extract in collutory
The collutory constitutive material of embodiment 6 to embodiment 10 and weight percent content are as following table 3:
The preparation method of collutory in embodiment 6:
First Caulis Sinomenii extract, nipalgin mixed ester sodium are added stirring and dissolving in edible ethanol and is placed in temporary pot, sorbitol, deionization, castor oil hydrogenated-40 are added in agitated kettle and stirs 10 minutes, alcoholic solution in temporary pot is added in agitated kettle and stir 10 minutes, finally add essence and stir 5 minutes, stop stirring, make after sampling detection is qualified.
The production technology of embodiment 7 to embodiment 10 is with reference to embodiment 6.
Embodiment 11 ~ 15: the application of Caulis Sinomenii extract in dentifrice
The dentifrice constitutive material of embodiment 11 to embodiment 15 and weight percent content are as following table 4:
The preparation method of dentifrice in embodiment 11 ~ 15:
Add after the opaque raw materials such as natural whiting, calcium phosphate dibasic dihydrate, silicon dioxide, sodium carboxymethyl cellulose, sodium lauryl sulphate, saccharin sodium, nipalgin mixed ester sodium are weighed up by formula consumption in mixing agitator to stir and add Caulis Sinomenii extract after 20 minutes and stir 10 minutes; finally add essence, sorbitol stir after 20 minutes shut down, sampling detect qualified after make.
Embodiment 16 ~ 20: the application of Caulis Sinomenii extract in throat lozenge
The throat lozenge constitutive material of embodiment 16 to embodiment 20 and weight percent content are as following table 5:
The preparation technology of embodiment 16 to embodiment 20 adopts existing throat lozenge production technology.
Example 21 ~ 25: the application of Caulis Sinomenii extracting solution in chewing gum:
The chewing gum constitutive material of embodiment 21 to embodiment 25 and weight percent content are as following table 6:
Claims (11)
1. Caulis Sinomenii extract is preparing the application in oral cavity nursing health products, it is characterized in that: in the technique preparing oral care product, Caulis Sinomenii extract is added in oral cavity nursing health products as the sole active agent of analgesic activity, the extracting method of described Caulis Sinomenii extract is by broken for Caulis Sinomenii granulating, 3 hours are extracted with the alcohol heating reflux of 10 times amount, extract 3 times, then extracting solution concentrating under reduced pressure is dried to powdery.
2. Caulis Sinomenii extract according to claim 1 is preparing the application in oral cavity nursing health products, it is characterized in that: described Caulis Sinomenii extract is preparing the raw material as analgesic activity in toothpaste technique.
3. Caulis Sinomenii extract according to claim 2 is preparing the application in oral cavity nursing health products, it is characterized in that: the percentage by weight of described Caulis Sinomenii extract in total mastic of toothpaste is 5 ~ 15.0%.
4. Caulis Sinomenii extract according to claim 1 is preparing the application in oral cavity nursing health products, it is characterized in that: described Caulis Sinomenii extract is preparing the raw material as analgesic activity in collutory technique.
5. Caulis Sinomenii extract according to claim 4 is preparing the application in oral cavity nursing health products, it is characterized in that: the percentage by weight of described Caulis Sinomenii extract in the raw material of collutory is 5 ~ 15%.
6. Caulis Sinomenii extract according to claim 1 is preparing the application in oral cavity nursing health products, it is characterized in that: described Caulis Sinomenii extract is preparing the raw material as analgesic activity in dentifrice technique.
7. Caulis Sinomenii extract according to claim 6 is preparing the application in oral cavity nursing health products, it is characterized in that: the percentage by weight of described Caulis Sinomenii extract in dentifrice raw material is 5.0 ~ 15.0%.
8. Caulis Sinomenii extract according to claim 1 is preparing the application in oral cavity nursing health products, it is characterized in that: described Caulis Sinomenii extract is preparing the raw material as analgesic activity in throat lozenge technique.
9. Caulis Sinomenii extract according to claim 8 is preparing the application in oral cavity nursing health products, it is characterized in that: the percentage by weight of described Caulis Sinomenii extract in throat lozenge raw material is 5 ~ 15%.
10. Caulis Sinomenii extract according to claim 1 is preparing the application in oral cavity nursing health products, it is characterized in that: described Caulis Sinomenii extract is preparing the raw material as analgesic activity in chewing gum technique.
11. Caulis Sinomenii extracts according to claim 10 are preparing the application in oral cavity nursing health products, it is characterized in that: the percentage by weight of described Caulis Sinomenii extract in chewing-gum material is 5 ~ 15%.
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Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103536482B (en) * | 2013-10-18 | 2016-07-20 | 柳州两面针股份有限公司 | Compound Chinese medicine extract is as sole active agent application in preparation oral cavity product |
| CN103550089A (en) * | 2013-10-18 | 2014-02-05 | 柳州两面针股份有限公司 | Application of caulis sinomenii extract and rhizoma imperatae extract in preparing oral care product |
| CN104523505A (en) * | 2014-12-16 | 2015-04-22 | 广西科技大学 | Application of bitter gourd root extract in preparation of toothpaste for treating gingiva pain |
| CN104523506A (en) * | 2014-12-16 | 2015-04-22 | 广西科技大学 | Application of securidaca inappendiculata extractive in preparation of oral care products for treating gingival ache |
| CN105362118B (en) * | 2015-07-14 | 2018-11-16 | 武汉华士特工业生物技术开发有限公司 | A kind of maca health-care toothpaste and preparation method |
| CN107320380A (en) * | 2017-07-26 | 2017-11-07 | 何家平 | A kind of new Chinese herbal medicine toothwash hydraulic art |
| CN107308065A (en) * | 2017-08-09 | 2017-11-03 | 何家平 | A kind of Novel Chinese herbal medicine toothpaste |
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