CN104523505A - Application of bitter gourd root extract in preparation of toothpaste for treating gingiva pain - Google Patents
Application of bitter gourd root extract in preparation of toothpaste for treating gingiva pain Download PDFInfo
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- CN104523505A CN104523505A CN201410774378.7A CN201410774378A CN104523505A CN 104523505 A CN104523505 A CN 104523505A CN 201410774378 A CN201410774378 A CN 201410774378A CN 104523505 A CN104523505 A CN 104523505A
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- momordicae charantiae
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Abstract
The invention provides an application of a bitter gourd root extract in preparation of a toothpaste for treating gingiva pain. By virtue of researches, the applicant discovers that the bitter gourd root extract has a good effect on treating gingiva pain, and the toothpaste with a function of treating gingiva pain can be prepared according to the effect.
Description
Technical field
The invention belongs to oral care techniques field, be specifically related to the application of Radix Momordicae Charantiae extract in the toothpaste of preparation treatment gingiva pain.
Background technology
Periodontal is the common oral diseases of the mankind, and its symptom mainly contains gingival hemorrhage, swollen swollen, pain etc.Toothache is the oral disease caused by many reasons, shows according to interrelated data, and there is the crowd more than 50% in China in the toothache of different times various degrees.
Toothpaste is indispensable articles for daily use during people live, and its basic function is cleaning teeth, fresh breath etc.In recent years, along with the health care consciousness of consumer constantly strengthens, more requirement is proposed to toothpaste, except cleaning teeth, fresh breath, require that there is prevention oral disease, oral cavity is had to the function of nursing health effect.The natural plant active component extracted from Chinese herbal medicine owing to having the incomparable advantage of the Western medicine such as safe, natural, and becomes the focus in market.
The technical scheme that Chinese patent CN 102961318 proposes a kind of Radix Rehmanniae, the Radix Angelicae Dahuricae, Folium Mori, Galla Chinensis, Radix orixae japonicae, Pericarpium Zanthoxyli five kinds of Chinese medicine extract combine as compound recipe; Chinese patent CN101244016 proposes a kind of using the natural plant active component technical scheme of naringin as antiinflammatory, hemostasis, analgesic activity; The compound recipe that Chinese patent CN103550089 proposes a kind of Caulis Sinomenii extract and Rhizoma Imperatae extract combines, as the technical scheme of the active component of analgesia, anastalsis; The compound recipe that Chinese patent CN103536471 proposes a kind of tetrahydropalmatine and Rhizoma Imperatae extract combines, as the technical scheme of analgesic bioactive substance.Technique scheme to the problems such as gingiva pain effect all preferably, but not yet finds that Radix Momordicae Charantiae extract is applied to the report in toothpaste as analgesic efficacy composition.CN103844262 proposes a kind of Chinese medicine composition containing Radix Momordicae Charantiae, and for the manufacture of a kind of pharynx-clearing throat-benefiting buccal tablet, and its extract not mentioned is as the application of analgesic composition in toothpaste.
Radix Momordicae Charantiae is the root heat-clearing and toxic substances removing of cucurbitaceous plant Fructus Momordicae charantiae, has and controls dysentery, have blood in stool, furuncle swelling toxin, the effects such as acute toothache." conventional glossary of Herbs and Drugs among the people " is recorded, the effect that Radix Momordicae Charantiae has " removing toxic substances of bringing down a fever, controls pyretic toothache, washout sore ".
Summary of the invention
The invention provides the application of Radix Momordicae Charantiae extract in the toothpaste of preparation treatment gingiva pain.
The present invention is directed to the problem of gingiva pain, propose a kind of application of natural plants Radix Momordicae Charantiae extract in toothpaste with good analgesic effect.The toothpaste made has obvious analgesic activity.
Radix Momordicae Charantiae extract of the present invention is exactly joined in toothpaste by the ancillary drug raw material of Radix Momordicae Charantiae extract as analgesic activity in the technique preparing toothpaste as the application scheme of toothpaste.
Further, the Radix Momordicae Charantiae extractive content described in the application of oral care product is 0.1%-10%.
Further, the Radix Momordicae Charantiae extractive content of the present invention described in the application of toothpaste is 0.2%-5%.
Further, the Radix Momordicae Charantiae extractive content of the present invention described in the application of toothpaste is 0.3%-3%.
Described Radix Momordicae Charantiae extract is the pure extract powder of 100% for active component, but is not limited to extract powder, also can be extracting solution or extractum etc.In time being applied to oral care product with other forms as extracting solution mode, the addition in formula should be converted to the amount of pure form of extract disclosed in the present invention.
In the present invention, the extracting method of Radix Momordicae Charantiae is: Radix Momordicae Charantiae is ground into below 100 orders, then uses 20 times of soak with ethanol 24 hours, and then at 70 DEG C, stir extraction 1 hour, elimination medicinal residues, obtain filtrate, decompression recycling ethanol, obtain Radix Momordicae Charantiae extract.
The extracting method of Radix Momordicae Charantiae is not limited to said method, and additive method also can be adopted to extract, as the additive method such as supercritical extraction, ultrasonic extraction extracts.
Such scheme is being prepared in toothpaste technique, and described Radix Momordicae Charantiae extract is the auxiliary material as analgesic activity, and in the prior aries such as friction fit agent, foaming agent, wetting agent, thickening agent, sweeting agent, antiseptic and spice, toothpaste is commonly used raw material and made toothpaste.The percentage by weight of described Radix Momordicae Charantiae extract in raw material of toothpaste can be 0.1%-10%, and this content is generally advisable with 0.3%-3%, and other various raw material dosage are by the formula of existing toothpaste manufacturing process.In existing toothpaste manufacturing process formula, other various raw material percentage compositions can be abrasivus 15%-50%, foaming agent 2%-3%, wetting agent 15%-30%, thickening agent 0.8%-1.3%, sweeting agent 0.1%-0.3%, antiseptic 0.1%-0.3%, the water of spice 0.8%-1.2% and surplus.
Abrasivus wherein can be that calcite in powder, any one or silicon dioxide of silicon dioxide powder and calcium hydrogen phosphate are combined; Foaming agent wherein can select sodium lauryl sulphate; Wetting agent wherein can select sorbitol, also can select the combination of sorbitol and propylene glycol, can also select the combination of sorbitol and glycerol; Thickening agent wherein can select the combination of the combination of sodium carboxymethyl cellulose or itself and guar gum or itself and carrageenan; Sweeting agent is wherein generally saccharin sodium; Antiseptic is wherein generally Nipagin complex esters; Spice wherein can be Herba Menthae Rotundifoliae or minty note or various fruit essences etc. as required.
The present invention adds the raw material of Radix Momordicae Charantiae extract as natural plant active component in toothpaste, not only use safety, and has significant analgesic activity.
The present invention, to the analgesic activity (hot plate method) carried out containing the toothpaste of Radix Momordicae Charantiae extract white mice, does positive control and blank is observed simultaneously.Experimental result shows, this toothpaste containing Radix Momordicae Charantiae extract and positive control medicine diclofenac diethylammonium group, compare with blank group, all can significantly improve the pain threshold values of white mice, have significant analgesic activity.
Detailed description of the invention
Following embodiment is convenient to understand the present invention better, but does not limit the present invention.Experimental technique in following embodiment, if no special instructions, is conventional method.In the following example, involved percentage ratio except as otherwise noted, is calculated all by weight percentage.
embodiment 1-5: the application of Radix Momordicae Charantiae extract in toothpaste.
In embodiment 1-5, toothpaste constitutive material and percentage composition are see table 1.
Table 1 toothpaste constitutive material and each raw material percentage composition
。
In the present embodiment 1, lotion of toothpaste adopts the one-step method cream production technology of conventional medicine toothpaste to make: abrasivus, sweeting agent, thickening agent, foaming agent, antiseptic etc. are carried out pre-dispersed, mixing in pre-dispersed still.Suck the liquid material such as wetting agent, extract, water calculated in Manufacturing medicine extract machine, and then suck above-mentioned powder, cream processed, finally add essence, can lotion of toothpaste be obtained.
The lotion of toothpaste production technology of embodiment 2-5 is with reference to embodiment 1.
test of pesticide effectiveness part
Analgesic test and result are see table 2.
Table 2 analgesic test and result
。
In table, data show, sample toothpaste group and diclofenac diethylammonium group compare analgesic effect aspect with blank group, and statistical significance has significant difference, can significantly improve mice pain threshold, show that the toothpaste group containing Radix Momordicae Charantiae extract has significant analgesic activity.
Last it is noted that the foregoing is only the preferred embodiments of the present invention, be not limited to the present invention, although with reference to previous embodiment to invention has been detailed description, for a person skilled in the art, it still can be modified to the technical scheme described in foregoing embodiments, or carries out equivalent replacement to wherein portion of techniques feature.Within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.
Claims (8)
1. the application of Radix Momordicae Charantiae extract in the toothpaste of preparation treatment gingiva pain.
2. application according to claim 1, is characterized in that: the mass percentage content of described Radix Momordicae Charantiae extract is 0.1%-10%.
3. application according to claim 2, is characterized in that: described Radix Momordicae Charantiae extract quality degree is 0.2%-5%.
4. application according to claim 3, is characterized in that: described Radix Momordicae Charantiae extract quality degree is 0.3%-3%.
5., according to the arbitrary described application of claim 1-4, it is characterized in that: the preparation method of described Radix Momordicae Charantiae extract is alcohol extraction, supercritical extraction or ultrasonic extraction.
6. there is a toothpaste for analgesic activity, it is characterized in that: the Radix Momordicae Charantiae extract in described toothpaste containing mass percent being 0.1-10%.
7. toothpaste according to claim 6, is characterized in that: the Radix Momordicae Charantiae extract in described toothpaste containing mass percent being 0.2-5%.
8. toothpaste according to claim 7, is characterized in that: the Radix Momordicae Charantiae extract in described toothpaste containing mass percent being 0.3-3%.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410774378.7A CN104523505A (en) | 2014-12-16 | 2014-12-16 | Application of bitter gourd root extract in preparation of toothpaste for treating gingiva pain |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201410774378.7A CN104523505A (en) | 2014-12-16 | 2014-12-16 | Application of bitter gourd root extract in preparation of toothpaste for treating gingiva pain |
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| CN104523505A true CN104523505A (en) | 2015-04-22 |
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| CN201410774378.7A Pending CN104523505A (en) | 2014-12-16 | 2014-12-16 | Application of bitter gourd root extract in preparation of toothpaste for treating gingiva pain |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106692258A (en) * | 2016-12-21 | 2017-05-24 | 陈绍良 | Medical application of bitter guard and bitter guard extract |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1698577A (en) * | 2005-05-24 | 2005-11-23 | 浙江大学 | Oral cavity cleaning health products containing balsam pear leaf and making method thereof |
| CN1927259A (en) * | 2006-08-30 | 2007-03-14 | 深圳市华南动力生物科技有限公司 | Antifungal pharmaceutical composition for preventing patient fungus infection |
| CN102028639A (en) * | 2009-09-28 | 2011-04-27 | 王小兵 | Bitter gourd drug toothpaste |
| CN102961295A (en) * | 2012-12-14 | 2013-03-13 | 柳州两面针股份有限公司 | Application of caulis sinomenii extract to preparation of oral care products |
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2014
- 2014-12-16 CN CN201410774378.7A patent/CN104523505A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1698577A (en) * | 2005-05-24 | 2005-11-23 | 浙江大学 | Oral cavity cleaning health products containing balsam pear leaf and making method thereof |
| CN1927259A (en) * | 2006-08-30 | 2007-03-14 | 深圳市华南动力生物科技有限公司 | Antifungal pharmaceutical composition for preventing patient fungus infection |
| CN102028639A (en) * | 2009-09-28 | 2011-04-27 | 王小兵 | Bitter gourd drug toothpaste |
| CN102961295A (en) * | 2012-12-14 | 2013-03-13 | 柳州两面针股份有限公司 | Application of caulis sinomenii extract to preparation of oral care products |
Non-Patent Citations (1)
| Title |
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| 南京中医药大学: "《中药大辞典》", 31 March 2006 * |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106692258A (en) * | 2016-12-21 | 2017-05-24 | 陈绍良 | Medical application of bitter guard and bitter guard extract |
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Application publication date: 20150422 |